MCID: INT071
MIFTS: 45

Intestinal Perforation

Categories: Gastrointestinal diseases

Aliases & Classifications for Intestinal Perforation

MalaCards integrated aliases for Intestinal Perforation:

Name: Intestinal Perforation 12 43 15 17 71
Perforation of Intestine 12 32

Classifications:



External Ids:

Disease Ontology 12 DOID:2074
ICD9CM 34 569.83
MeSH 43 D007416
NCIt 49 C39611
SNOMED-CT 67 56905009
ICD10 32 K63.1
UMLS 71 C0021845

Summaries for Intestinal Perforation

MalaCards based summary : Intestinal Perforation, also known as perforation of intestine, is related to behcet syndrome and perinatal necrotizing enterocolitis. An important gene associated with Intestinal Perforation is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Folate Metabolism and Photodynamic therapy-induced NF-kB survival signaling. The drugs Meropenem and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and small intestine, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Intestinal Perforation

Diseases related to Intestinal Perforation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 585)
# Related Disease Score Top Affiliating Genes
1 behcet syndrome 32.0 NOD2 IL6 CTLA4 CRP ALB
2 perinatal necrotizing enterocolitis 31.2 NOD2 IL6 FABP2 CRP
3 intestinal tuberculosis 30.9 NOD2 CRP ALB
4 crohn's disease 30.7 NOD2 IL6 CRP ALB
5 typhoid fever 30.6 IL6 GPT CRP ALB
6 abdominal tuberculosis 30.6 NOD2 CRP ALB
7 appendicitis 30.6 IL6 CRP ALB
8 tuberculous peritonitis 30.3 CRP ALB
9 intussusception 30.2 VEGFA IL6 CRP ALB
10 chorioamnionitis 30.2 VEGFA IL6 CRP
11 polyarteritis nodosa 30.1 IL6 GPT CRP
12 ileitis 30.1 NOD2 IL6 FABP2
13 necrotizing fasciitis 30.1 IL6 CRP ALB
14 peptic ulcer disease 30.0 NFKB1 ATP4A ATP12A ALB
15 temporal arteritis 29.9 IL6 CTLA4 CRP
16 spondylitis 29.9 NOD2 IL6 CRP
17 diverticulitis 29.9 IL6 CRP ATP4A ATP12A ALB
18 lung abscess 29.9 IL6 CRP ALB
19 pneumocystosis 29.9 IL6 CRP ALB
20 superior mesenteric artery syndrome 29.9 CRP ATP4A ATP12A
21 gastric dilatation 29.8 CRP ATP4A ATP12A
22 familial mediterranean fever 29.8 NOD2 IL6 CRP
23 eosinophilic gastroenteritis 29.8 ATP4A ATP12A ALB
24 active peptic ulcer disease 29.8 CRP ATP4A ATP12A ALB
25 angiodysplasia 29.8 VEGFA ATP4A ATP12A
26 gastrointestinal tuberculosis 29.7 NOD2 GPT CRP ALB
27 disseminated intravascular coagulation 29.7 IL6 GPT CRP
28 paralytic ileus 29.6 GPT CRP ALB
29 cystitis 29.6 VEGFA KRT7 IL6 CRP
30 endocarditis 29.6 IL6 CRP ALB
31 salmonellosis 29.6 IL6 GPT ALB
32 mediastinitis 29.6 CRP ATP4A ATP12A ALB
33 meningitis 29.5 VEGFA IL6 CRP ALB
34 congestive heart failure 29.5 VEGFA IL6 CRP ALB
35 toxic megacolon 29.4 MIR4500HG CRP ATP4A ATP12A ALB
36 compartment syndrome 29.4 IL6 GPT CRP ALB
37 acute cystitis 29.4 IL6 GPT CRP ALB
38 volvulus of midgut 29.4 GPT CRP ATP4A ATP12A ALB
39 vascular disease 29.3 VEGFA NOS1 IL6 CRP ALB
40 portal hypertension 29.2 VEGFA GPT ALB
41 obstructive jaundice 29.2 IL6 GPT CRP ALB
42 intestinal obstruction 28.9 NOD2 KRT7 IL6 GPT CRP ATP4A
43 respiratory failure 28.9 NKX2-1 IL6 GPT CRP ALB
44 leptin deficiency or dysfunction 28.9 IL6 GPT FABP2 CRP ALB
45 arthritis 28.8 VEGFA NOD2 IL6 CTLA4 CRP ALB
46 inflammatory bowel disease 28.8 VEGFA NOD2 NFKB1 IL6 CTLA4 CRP
47 hepatitis b 28.7 IL6 GPT CTLA4 ALB
48 thrombocytopenia 28.7 IL6 GPT CTLA4 CRP ALB
49 celiac disease 1 28.4 NOD2 IL6 FABP2 CTLA4 CRP ATP4A
50 aspiration pneumonia 28.4 IL6 GPT CRP ATP4A ATP12A ALB

Comorbidity relations with Intestinal Perforation via Phenotypic Disease Network (PDN): (show all 15)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Cecal Benign Neoplasm Colorectal Cancer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Intestinal Obstruction
Paralytic Ileus Peritonitis
Protein-Energy Malnutrition Rectosigmoid Junction Neoplasm
Respiratory Failure

Graphical network of the top 20 diseases related to Intestinal Perforation:



Diseases related to Intestinal Perforation

Symptoms & Phenotypes for Intestinal Perforation

GenomeRNAi Phenotypes related to Intestinal Perforation according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.68 PRODH
2 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.68 KRT7
3 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.68 PRODH
4 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.68 NOD2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.68 NOD2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.68 NOD2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.68 KRT7 NOD2 PRODH
8 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.68 PRODH
9 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.68 PRODH
10 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.68 PRODH
11 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.68 NOD2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.68 PRODH
13 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.68 NOD2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.68 PRODH
15 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.68 NOD2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.68 PRODH
17 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.68 PRODH
18 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.68 KRT7
19 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.68 NOD2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.68 PRODH
21 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.68 PRODH

MGI Mouse Phenotypes related to Intestinal Perforation:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.9 ALB ATP12A ATP4A CTLA4 IL6 NFKB1
2 endocrine/exocrine gland MP:0005379 9.61 ALB ATP4A CTLA4 IL6 NFKB1 NKX2-1
3 homeostasis/metabolism MP:0005376 9.53 ALB ATP12A ATP4A CRP CTLA4 FABP2

Drugs & Therapeutics for Intestinal Perforation

Drugs for Intestinal Perforation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Meropenem Approved, Investigational Phase 3 96036-03-2, 119478-56-7 64778 441130
2
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
3
Clavulanate Approved, Vet_approved Phase 3 58001-44-8 5280980
4
Doripenem Approved, Investigational Phase 3 148016-81-3 73303
5 Pharmaceutical Solutions Phase 2, Phase 3
6 Anti-Infective Agents Phase 3
7 Anti-Bacterial Agents Phase 3
8 Amoxicillin-Potassium Clavulanate Combination Phase 3
9 beta-Lactamase Inhibitors Phase 3
10
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
11
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
12
Acetaminophen Approved Phase 2 103-90-2 1983
13
Indomethacin Approved, Investigational Phase 2 53-86-1 3715
14
Mupirocin Approved, Investigational, Vet_approved Phase 2 12650-69-0 446596
15
Petrolatum Approved, Investigational Phase 2 8009-03-8
16 Antimitotic Agents Phase 2
17 Soybean oil, phospholipid emulsion Phase 2
18 Parenteral Nutrition Solutions Phase 2
19 Fat Emulsions, Intravenous Phase 2
20 Soy Bean Phase 2
21 Dermatologic Agents Phase 2
22 Emollients Phase 2
23 Immunoglobulins Phase 1
24 Antibodies Phase 1
25 Antibodies, Monoclonal Phase 1
26
Bupivacaine Approved, Investigational 38396-39-3, 2180-92-9 2474
27
Epinephrine Approved, Vet_approved 51-43-4 5816
28
Lidocaine Approved, Vet_approved 137-58-6 3676
29
Racepinephrine Approved 329-65-7 838
30
Ceftazidime Approved 72558-82-8, 78439-06-2 5481173
31
Vancomycin Approved 1404-90-6 441141 14969
32
Ibuprofen Approved 15687-27-1 3672
33 Anesthetics, Local
34 Hematinics
35 Epinephryl borate
36 Respiratory System Agents
37 Anti-Asthmatic Agents
38 Hormone Antagonists
39 glucocorticoids
40 Hormones
41
Beclomethasone 4419-39-0 20469
42 Lactoferrin
43 Antibiotics, Antitubercular
44 Antitubercular Agents
45 Cola
46 Liver Extracts
47 Anesthetics
48 Central Nervous System Depressants
49 Analgesics, Opioid
50 Analgesics

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Randomized Evaluation of the Use of Plastic Bags to Prevent Neonatal Hypothermia in Developing Countries-Part IV Completed NCT01604447 Phase 4
2 Effects of Recto-colic Enemas of Butyrate on the Digestive Disorders of Very Low Birth Weight Preterms <1250 Grams. Clinical Trial Prospective, Monocentric, Randomized in Double-blinded. Terminated NCT01536483 Phase 2, Phase 3 Butyrate enemas
3 A Prospective, Randomized, Double-Blind, Multicenter Study to Establish the Safety and Tolerability of Doripenem Compared With Meropenem in Hospitalized Children With Complicated Intra-Abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
4 Phase II Study of Salvage Therapy With Sunitinib,Docetaxel and Platinum on Metastatic or Unresectable Non Small Cell Lung Cancer Unknown status NCT01019798 Phase 2 sunitinib, docetaxel, cisplatin
5 Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus in Preterm infants-a Multicenter Trial Completed NCT01958320 Phase 2 NSAID
6 Early Supplementation of Enteral Microlipid With and Without Fish Oil in Premature Infants With Enterostomies Completed NCT01674478 Phase 2
7 Randomized Controlled Trial of Mupirocin to Reduce Staphylococcus Aureus Colonization in Infants Hospitalized in a Neonatal Intensive Care Unit Recruiting NCT02967432 Phase 2 Mupirocin Topical Ointment;Petroleum Jelly
8 A Phase II Trial of Sunitinib and Nivolumab for KIT-mutated Advanced Melanoma Withdrawn NCT02400385 Phase 2 sunitinib;nivolumab
9 An Open-Label Trial of Tocilizumab in Schizophrenia Completed NCT01696929 Phase 1 Tocilizumab
10 A Randomized Controlled Trial of Adjunctive Tocilizumab in Schizophrenia Recruiting NCT02874573 Phase 1 Tocilizumab;Normal saline
11 Immunoreactive Trypsinogen in Infants With Intestinal Perforation Unknown status NCT01530828
12 Ultrasound Guided Transversus Abdominis Plane(TAP) Block in Intensive Care Unit(ICU) for Postoperative Analgesia After Open Colon Resection: a Double Blind Randomized Controlled Trial Unknown status NCT03198338 0.25% Bupivacaine, 0.5mL/kg;Normal Saline
13 Probiotics Supplementation and Length of Hospital Stay in Neonates With Gastrointestinal Surgery Unknown status NCT03266315
14 Procalcitonin Ratio's Impact on the Decision Upon On-demand Relaparotomy in Septic Peritonitis Completed NCT01768936
15 Observational Study of Surgical Treatment of Necrotizing Enterocolotis or Isolated Intestinal Perforation Completed NCT01223261
16 Evaluation of the Ability to Detect Bowel Gas During Laparoscopic Surgery Completed NCT02679118
17 Intestinal Perforation in Patients Receiving an Orthtopic Liver Transplantation in the Montpellier University Hospital: a Retrospective and Observational Study. Completed NCT04180735
18 A Multi-center Randomized Trial of Laparotomy vs. Drainage as the Initial Surgical Therapy for ELBW Infants With Necrotizing Enterocolitis (NEC) or Isolated Intestinal Perforation (IP): Outcomes at 18-22 Months Adjusted Age Completed NCT01029353
19 Effect of Continuous Thoracic Epidural Analgesia on Gut Motility Following Emergency Laparotomy for Intestinal Perforation Under General Anesthesia Completed NCT03145389
20 Early Supplementation of Enteral Lipid With Combination of Microlipid and Fish Oil in Infants With Enterostomy Completed NCT01306838 Early Phase 1
21 Factors Associated With Relapses in Patients Suffering From Clostridium Difficile Infection: Immune Response Completed NCT02440438
22 Prediction of Feeding Problems in Prostaglandin-dependent Prematurely Born Infants With Congenital Heart Disease Completed NCT01126372
23 Splanchnic Oxygenation and Perfusion Response to Enteral Feeds in Preterm Infants With Abnormal Antenatal Doppler: Pattern Assessment and Correlation With Feeding Intolerance Completed NCT02971566
24 Effect of Patent Ductus Arteriosus on Splanchnic Oxygenation at Enteral Feeding Introduction in Preterm Infants Completed NCT03723889
25 Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis Completed NCT01735578
26 Intestinal Microbiota and Short Term Outcomes in Very Low Birth Weight Infants Fed Primarily Donor Human Milk Compared to Infants Fed Primarily Mother's Own Milk Completed NCT02573779
27 A Dose-Ranging Study to Assess the Effect of Inhaled Corticosteroids in Ventilated Preterm Neonates Completed NCT03503994 Inhaled Beclomethasone Dipropionate Monohydrate
28 Prospective Registry The Treatment Of Upper And Lower Intestinal Anastomotic Leaks And Perforations Recruiting NCT02477930
29 Proximal Remnant Intestinal Colonization in Newborn Infants With Enterostomy: a Longitudinal Study Recruiting NCT03340259
30 Pathophysiology of Perioperative Fluid Management in Patients Un-dergoing High Risk Emergency Laparotomy, a Prospective Descriptive Cohort Study Recruiting NCT03997721
31 A Randomized Multicenter Open-label Controlled Trial to Show That Mucous Fistula Refeeding Reduces the Time From Enterostomy Closure to Full Enteral Feeds (MUCous FIstula REfeeding ("MUC-FIRE") Trial) Recruiting NCT03469609
32 Symptomatic Uncomplicated Diverticular Disease: a lactofErriN piLot studY Recruiting NCT03490279
33 Standardized Perioperative Management of Patients Operated With Acute Abdominal Surgery in a High-risk Emergency Setting Recruiting NCT03549624
34 Extensively Hydrolyzed Liquid Human Milk Fortifier Versus Liquid Human Milk Fortifier With Supplemental Liquid Protein Recruiting NCT03001479
35 Tolerance of Early High Protein Nutrition of the Critically Ill: Comparison of a Protein-rich Enteral Formula With a Standardized High Carbohydrate Product on Total Calorie and Protein Intake Recruiting NCT02678325
36 Randomized Multicentric Clinical Trial, Efficcacy of the Treatment Application on Peritonitis in Automated Peritoneal Dialysis (APD); Comparision Between APD Versus Ambulatory Dialysis. Recruiting NCT04077996
37 Necrotizing Enterocolitis (NEC) & Platelet-Activating Factor (PAF)-Stimulated Protein Translation in Premature Infants Recruiting NCT00747851
38 Safeguarding the Brain of Our Smallest Children - an Investigator-initiated, Pragmatic, Open Label, Multinational Randomized Phase IIIclinical Trial Evaluating Treatment Based on Near-infrared Spectroscopy Monitoring Versus Treatment as Usual in Premature Infants Recruiting NCT03770741
39 Non-invasive Auxiliary Diagnosis of Colorectal Cancer and Advanced Adenoma by Detecting Cancer-specific Methylation Signatures in Plasma ctDNA Recruiting NCT03828396
40 Delayed Small-Bowel Anastomosis in Patients With Postoperative Peritonitis Due to Nontraumatic Small-Bowel Perforation and Anastomotic Leak: Cohort Study Active, not recruiting NCT03690687
41 Evaluation of Post-Discharge Growth and Development of Infants Who Received Donor Human Milk Products in the NICU Active, not recruiting NCT01483079
42 The Role of Indocyanine Green Angiography Fluorescence on Intestinal Resections in Pediatric Surgery. Not yet recruiting NCT04020939 Indocyanine Green
43 Vacuum Assisted Closure Versus On-demand Relaparotomy in Patients With Fecal or Diffuse Peritonitis: A Multicenter Randomized Controlled Trial Not yet recruiting NCT03932461
44 Enhanced Recovery After Surgery Versus Conventional Approach in Peptic Perforation-A Randomized Control Trial Not yet recruiting NCT04194060
45 Doppler Ultrasonography in Assessment of Graft Hemodynamics After Living-Donor Liver Transplantation in Al-Rajhi Liver Hospital Not yet recruiting NCT03893773
46 Continuous Versus Intermittent Bolus Feeding in Very Preterm Infants - Effects on Respiratory Morbidity: A Multicentre Randomised Controlled Clinical Trial Not yet recruiting NCT03961139
47 A Prospective Multicenter Randomized Controlled Clinical Trial to Compare the Method of Protective Diverting Loop Ileostomy With or Without the Support of a Plastic Rod Terminated NCT00959738
48 Timing of PDA Closure and Respiratory Outcome in Premature Infants Terminated NCT00802685 Early ibuprofen
49 Prospective Randomized Trial of Anterograde Single Balloon Versus Spirus Enteroscopy in Patients With Suspected Small Bowel Disease Terminated NCT01853241
50 Early Delivery in Fetal Gastroschisis: a Randomized Controlled Trial of Elective Early Delivery Versus Routine Obstetrical Care Terminated NCT01884324

Search NIH Clinical Center for Intestinal Perforation

Cochrane evidence based reviews: intestinal perforation

Genetic Tests for Intestinal Perforation

Anatomical Context for Intestinal Perforation

MalaCards organs/tissues related to Intestinal Perforation:

40
Colon, Liver, Small Intestine, Lung, Bone, T Cells, Kidney

Publications for Intestinal Perforation

Articles related to Intestinal Perforation:

(show top 50) (show all 2147)
# Title Authors PMID Year
1
A Pharmacoepidemiologic Study of the Safety and Effectiveness of Clindamycin in Infants. 61
31725114 2020
2
Colonic Perforation as Initial Presentation of Amyloid Disease: Case Report and Literature Review. 61
31728786 2020
3
Laparoscopy assisted ventriculoperitoneal shunt placement in children. 61
31718873 2020
4
Safety of synthetic and biological DMARDs: a systematic literature review informing the 2019 update of the EULAR recommendations for the management of rheumatoid arthritis. 61
32033941 2020
5
A case of systemic lupus erythematosus with rectal necrosis. 61
31924142 2020
6
Patient Selection for Adjuvant Chemotherapy in High-Risk Stage II Colon Cancer: A Systematic Review and Meta-Analysis. 61
31934881 2020
7
A multi-institutional experience in vascular Ehlers-Danlos syndrome diagnosis. 61
31353273 2020
8
New simple low-cost surgical approach to complex jejuno-ileal atresia. 61
31914866 2020
9
A novel interstitial deletion of chromosome 2q21.1-q23.3: Case report and literature review. 61
31989799 2020
10
Complications of enterostomy and related risk factor analysis of very early onset inflammatory bowel disease with interleukin-10 signalling deficiency: a single-centre retrospective analysis. 61
31931724 2020
11
Inguinal hernias in children. 61
32008266 2020
12
Intestinal necrosis related to administration of cation exchange resin without sorbitol: A retrospective analysis of 61 patients with end-stage renal diseases. 61
31997484 2020
13
Retroperitoneal Cecal Perforation Resulting from Obstructive Ascending Colon Adenocarcinoma. 61
31970010 2020
14
Endoscopic treatment of a foreign body-associated colonic perforation. 61
31820075 2020
15
Timing of enterostomy closure for neonatal isolated intestinal perforation. 61
31954555 2020
16
Intestinal perforation in unusual location. 61
31696721 2019
17
Subcutaneous emphysema secondary to intestinal perforation in a patient with Crohn's disease. 61
31488321 2019
18
Consecutive Versus Selective Primary and Revisional Single Incision Laparoscopic Bariatric Surgery: Personal Experience in 330 Cases. 61
31858397 2019
19
In utero ileal volvulus and intestinal perforation associated with enteric duplication cyst presenting with preterm labour and acute abdomen in newborn. 61
31780621 2019
20
A novel mouse model of sporadic colon cancer induced by combination of conditional Apc genes and chemical carcinogen in the absence of Cre recombinase. 61
30859181 2019
21
The Impact of Surgical Intervention on Neurodevelopmental Outcomes in Very Low Birth Weight Infants: a Nationwide Cohort Study in Korea. 61
31701701 2019
22
Riolan arch pseudoaneurysm hemorrhage after endovascular covered stent-graft treatment of an abdominal aortic aneurysm: A case report. 61
31770196 2019
23
Detection of Cytomegalovirus in Intestinal Tissue of Infants with Necrotizing Enterocolitis or Spontaneous Intestinal Perforation. 61
31493911 2019
24
Colonisation of the proximal intestinal remnant in newborn infants with enterostomy: a longitudinal study protocol. 61
31767579 2019
25
An Extraordinary Complication in a Child With Combined Familial Mediterranean Fever and Inflammatory Bowel Disease: Multiple Ileal Perforations. 61
31688804 2019
26
Anaplastic Large T-Cell Lymphoma in the Intestine of Dogs. 61
31170900 2019
27
Surgical Complications Requiring an Early Relaparotomy in HIV-Infected Liver Transplant Recipients: Risk Factors and Impact on Survival. 61
31607626 2019
28
Injuries due to foreign body ingestion and insertion in children: 10 years of experience at a single institution. 61
31693772 2019
29
Delayed diagnosis of spontaneous intestinal perforation among very low birth weight neonates: A single center experience. 61
31462722 2019
30
Scrotal ulcerations in a newborn secondary to unnoticed prenatal intestinal perforation. 61
31273008 2019
31
Intestinal perforation after liposuction. 61
30683272 2019
32
[Analysis on operational safety of chronic radiation intestinal injury]. 61
31770834 2019
33
Early post-liver transplant surgical morbidity in HIV-infected recipients: risk factor for overall survival? A nationwide retrospective study. 61
31050044 2019
34
An Extraordinary Complication in a Child With Combined Familial Mediterranean Fever and Inflammatory Bowel Disease: Multiple Ileal Perforations. 61
31634223 2019
35
Outcomes of infants born at 23 and 24 weeks' gestation with gut perforation. 61
31072679 2019
36
The relationship between antenatal indomethacin as a tocolytic drug and neonatal outcomes: a retrospective cohort study. 61
31597542 2019
37
Short- and Long-Term Outcomes of Extremely Preterm Infants in Japan According to Outborn/Inborn Birth Status. 61
31232855 2019
38
Intestinal Perforation Due to Crohn's Ileitis Immunosuppression Related Lymphoma and Meckel's Diverticulum. 61
29730434 2019
39
Long-term outcomes of very low birth weight infants with spontaneous intestinal perforation: A retrospective case-matched cohort study. 61
31084913 2019
40
Delayed diagnosis of anorectal malformations in neonates. 61
31450268 2019
41
Low tidal volume ventilation strategy and organ functions in patients with pre-existing systemic inflammatory response. 61
31920228 2019
42
Comparison of Acute Abdominal Surgical Outcomes of Extremely-Low-Birth-Weight Neonates according to Differential Diagnosis. 61
31496138 2019
43
Recurrent Cervical Cancer with Intestinal Perforation That Was Related to Bevacizumab after Long-term NSAIDs Administration and Was Treated with Laparoscopy-assisted Anastomosis. 61
31448394 2019
44
Methicillin-Resistant Staphylococcus aureus Meningitis from Transanal Migration of a Ventriculoperitoneal Shunt. 61
31402070 2019
45
Surgical Outcomes in Patients with Abdominal Cocoon: Series of 15 Patients. 61
31011822 2019
46
No need for surgery? Patterns and outcomes of blunt abdominal trauma. 61
31709301 2019
47
Surgery for intra-abdominal abscess due to intestinal perforation caused by toothpick ingestion: Two case reports. 61
31490392 2019
48
Granulomatosis with polyangiitis with intestinal involvement successfully treated with rituximab and surgery. 61
31401575 2019
49
Synergistic effect of enteral nutrition on remission induction in a patient with penetrating Crohn disease: A case report. 61
31393390 2019
50
Dosing and Safety of Off-label Use of Caffeine Citrate in Premature Infants. 61
31101409 2019

Variations for Intestinal Perforation

Expression for Intestinal Perforation

Search GEO for disease gene expression data for Intestinal Perforation.

Pathways for Intestinal Perforation

Pathways related to Intestinal Perforation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 NFKB1 IL6 CRP ALB
2
Show member pathways
10.93 VEGFA NFKB1 IL6
3 10.51 VEGFA NFKB1 IL6

GO Terms for Intestinal Perforation

Biological processes related to Intestinal Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.33 VEGFA NOS1 IL6
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.17 VEGFA USF2 NOS1 NOD2 NKX2-1 NFKB1
3 negative regulation of lipid storage GO:0010888 8.96 IL6 CRP

Molecular functions related to Intestinal Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Intestinal Perforation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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