Intestinal Pseudo-Obstruction disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Intestinal Pseudo-Obstruction

MalaCards integrated aliases for Intestinal Pseudo-Obstruction:

Name: Intestinal Pseudo-Obstruction ¹¹ ¹⁹ ⁴² ⁷⁵ ²⁸ ⁵³ ⁵ ⁴³ ¹⁴ ¹⁶ ⁷¹

Chronic Intestinal Pseudoobstruction ¹⁹ ⁵⁸ ²⁸ ⁵

Chronic Intestinal Pseudo-Obstruction ¹¹ ⁵³ ⁷¹

Cipo ¹⁹ ⁴² ⁵⁸

Neuronal Intestinal Dysplasia ¹¹ ⁷¹

Familial Visceral Neuropathy ⁴² ⁷¹

Hollow Visceral Myopathy ¹⁹ ⁷¹

Paralytic Ileus ⁴² ⁷¹

Congenital Idiopathic Intestinal Pseudoobstruction ⁷¹

Chronic Idiopathic Intestinal Pseudo-Obstruction ⁴²

Pseudointestinal Obstruction Syndrome ⁴²

Congenital Short Bowel Syndrome ⁴²

Pseudo-Obstruction of Intestine ⁴²

Intestinal Pseudoobstruction ¹⁹

Visceral Myopathy, Familial ⁷¹

Familial Visceral Myopathy ⁴²

Pseudoobstructive Syndrome ⁴²

Enteric Neuropathy ⁴²

Ciip ⁴²

Ipo ⁴²

Characteristics:

Age Of Onset:

Chronic Intestinal Pseudoobstruction: All ages ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the digestive system

Other diseases of intestines

Other functional intestinal disorders

Other specified functional intestinal disorders

Orphanet: ⁵⁸

Rare gastroenterological diseases

External Ids:

Disease Ontology ¹¹ DOID:0080072

MeSH ⁴³ D007418

NCIt ⁴⁹ C34733

SNOMED-CT ⁶⁸ 235825006

ICD10 via Orphanet ³² K59.8

UMLS via Orphanet ⁷² C0238062

Orphanet ⁵⁸ ORPHA2978

SNOMED-CT via HPO ⁶⁹ 253789002 29980002 367403001 more

EFO ¹⁶ EFO_1000988

UMLS ⁷¹ C0021847 C0030446 C0238062 more

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Summaries for Intestinal Pseudo-Obstruction

MedlinePlus Genetics: ⁴² Intestinal pseudo-obstruction is a condition characterized by impairment of the muscle contractions that move food through the digestive tract. It can occur at any time of life, and its symptoms range from mild to severe. The condition may arise from abnormalities of the gastrointestinal muscles themselves (myogenic) or from problems with the nerves that control the muscle contractions (neurogenic).Intestinal pseudo-obstruction leads to a buildup of partially digested food in the intestines. This buildup can cause abdominal swelling (distention) and pain, nausea, vomiting, and constipation or diarrhea. Affected individuals experience loss of appetite and impaired ability to absorb nutrients, which may lead to malnutrition. These symptoms resemble those of an intestinal blockage (obstruction), but in intestinal pseudo-obstruction no blockage is found.Depending on the cause of intestinal pseudo-obstruction, affected individuals can have additional signs and symptoms. Some people with intestinal pseudo-obstruction have bladder dysfunction such as an inability to pass urine. Other features may include decreased muscle tone (hypotonia) or stiffness (spasticity) of the torso and limbs, weakness in the muscles that control eye movement (ophthalmoplegia), intellectual disability, seizures, unusual facial features, or recurrent infections.When intestinal pseudo-obstruction occurs by itself, it is called primary or idiopathic intestinal pseudo-obstruction. The disorder can also develop as a complication of another health problem; in these cases, it is called secondary intestinal pseudo-obstruction. The condition can be episodic (acute) or persistent (chronic).

MalaCards based summary: Intestinal Pseudo-Obstruction, also known as chronic intestinal pseudoobstruction, is related to visceral myopathy 1 and congenital short bowel syndrome, and has symptoms including vomiting An important gene associated with Intestinal Pseudo-Obstruction is ACTG2 (Actin Gamma 2, Smooth Muscle), and among its related pathways/superpathways are Signal Transduction and Neural crest differentiation. The drugs Prucalopride and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, smooth muscle and small intestine, and related phenotypes are intestinal malrotation and pyloric stenosis

GARD: ¹⁹ Chronic intestinal pseudo-obstruction (CIPO) is a rare disease characterized by repetitive episodes or continuous symptoms of bowel obstruction when no blockage exists. Problems with nerves, muscles, or interstitial cells of Cajal (the cells that set the pace of intestinal contractions) prevent normal contractions and cause problems with the movement of food, fluid, and air through the intestines. The most common symptoms are abdominal swelling or bloating (distention), vomiting, abdominal pain, failure to thrive, diarrhea, constipation, feeding intolerance and urinary symptoms. CIPO can occur in people of any age. It may be primary or secondary. Primary or idiopathic (where the cause is unknown) CIPO occurs by itself. Secondary CIPO develops as a complication of another medical condition. In some people with CIPO, the condition is caused by variations affecting the FLNA or ACTG2 gene. Before making the diagnosis other conditions with similar symptoms should be ruled out.

Orphanet: ⁵⁸ Chronic intestinal pseudo-obstruction (CIPO) is a rare gastrointestinal motility disorder characterized by recurring episodes resembling mechanical obstruction in the absence of organic, systemic, or metabolic disorders, and without any physical obstruction being detected by X-ray or during surgery. CIPO develops predominantly in children and may be present at birth.

Disease Ontology: ¹¹ A colonic disease that is characterized by bowel obstruction resulting from impairment of the muscle contractions that move food through the digestive tract.

Wikipedia: ⁷⁵ Intestinal pseudo-obstruction (IPO) is a clinical syndrome caused by severe impairment in the ability of... more...

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Related Diseases for Intestinal Pseudo-Obstruction

Diseases in the Intestinal Obstruction family:

Intestinal Pseudo-Obstruction

Diseases related to Intestinal Pseudo-Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 636)

#	Related Disease	Score	Top Affiliating Genes
1	visceral myopathy 1	33.0	MYH11 LMOD1 ACTG2
2	congenital short bowel syndrome	32.3	LOC112042785 FLNA CLMP
3	megacystis-microcolon-intestinal hypoperistalsis syndrome 1	32.3	TYMP SGO1 POLG MYH11 LMOD1 FLNA
4	intestinal obstruction	31.5	SGO1 RET FLNA EDNRB EDN3 ALB
5	myopathy	31.5	TYMP POLG MYH11 MT-TL1 LMOD1 ALB
6	microcolon	31.3	MYH11 LMOD1 ACTG2
7	mitochondrial neurogastrointestinal encephalomyopathy	31.1	TYMP POLG
8	hirschsprung disease 1	31.0	TLX2 SOX10 RET EDNRB EDN3 ALB
9	hydronephrosis	31.0	MYH11 LMOD1 ALB ACTG2
10	superior mesenteric artery syndrome	30.8	TYMP MLNR ALB
11	peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	30.7	SOX10 EDNRB EDN3
12	megacolon	30.6	TLX2 SOX10 RET EDNRB EDN3
13	waardenburg's syndrome	30.6	SOX10 RET EDNRB EDN3
14	waardenburg syndrome, type 4c	30.5	SOX10 EDNRB EDN3
15	waardenburg syndrome, type 2e	30.4	SOX10 EDNRB EDN3
16	patent ductus arteriosus 1	30.4	TFAP2B MYH11 FLNA ALB
17	chronic progressive external ophthalmoplegia	30.4	TYMP POLG MT-TL1
18	waardenburg syndrome, type 4a	30.4	SOX10 RET EDNRB EDN3
19	diabetic autonomic neuropathy	30.4	MLNR ALB
20	visceral myopathy 2	30.3	NDE1 MYH11
21	mitochondrial encephalomyopathy	30.3	TYMP POLG MT-TL1
22	mitral valve insufficiency	30.3	NDE1 MYH11 ALB
23	gastrointestinal stromal tumor	30.3	SOX10 RET MYH11 ALB
24	progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 4	30.1	TYMP POLG
25	intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked	11.8
26	intestinal pseudoobstruction with patent ductus arteriosus and natal teeth	11.7
27	chronic atrial and intestinal dysrhythmia	11.7
28	x-linked chronic idiopathic intestinal pseudo-obstruction	11.7
29	mitochondrial dna depletion syndrome 4b	11.5
30	systemic scleroderma	11.3
31	actg2 visceral myopathy	11.3
32	mungan syndrome	11.3
33	neuronal intestinal dysplasia, type b	11.2
34	neuronal intestinal dysplasia type a	11.2
35	autosomal dominant familial visceral neuropathy	11.2
36	visceral neuropathy-brain anomalies-facial dysmorphism-developmental delay syndrome	11.2
37	visceral neuropathy, familial, 2, autosomal recessive	11.2
38	myopathic intestinal pseudoobstruction	11.2
39	unclassified intestinal pseudoobstruction	11.2
40	visceral leiomyopathy, african degenerative	11.1
41	ileus	10.7
42	systemic lupus erythematosus	10.7
43	lupus erythematosus	10.7
44	systemic lupus erythematosus 1	10.7
45	amyloidosis	10.6
46	scleroderma, familial progressive	10.6
47	overgrowth syndrome	10.6
48	nutritional deficiency disease	10.5
49	gastrointestinal system disease	10.5
50	diarrhea	10.5

Graphical network of the top 20 diseases related to Intestinal Pseudo-Obstruction:

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Symptoms & Phenotypes for Intestinal Pseudo-Obstruction

Human phenotypes related to Intestinal Pseudo-Obstruction:

⁵⁸ ³⁰ (show all 7)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	intestinal malrotation ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002566
2	pyloric stenosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002021
3	abnormal nervous system morphology ³⁰	Frequent (33%)		HP:0012639
4	patent ductus arteriosus ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001643
5	abnormal platelet morphology ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0011875
6	abnormality of nervous system morphology ⁵⁸		Frequent (79-30%)
7	abnormal intestine morphology ⁵⁸		Very frequent (99-80%)

UMLS symptoms related to Intestinal Pseudo-Obstruction:

vomiting

MGI Mouse Phenotypes related to Intestinal Pseudo-Obstruction:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.9	ALB CLMP EDN3 EDNRB FLNA MYH11
2	cellular	MP:0005384	9.7	ALB EDNRB FLNA MYH11 NDE1 POLG
3	mortality/aging	MP:0010768	9.44	ALB CLMP EDN3 EDNRB FLNA MYH11

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Drugs & Therapeutics for Intestinal Pseudo-Obstruction

Drugs for Intestinal Pseudo-Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Prucalopride

Approved

Phase 3

179474-81-8

3052762

2

Gastrointestinal Agents

Phase 3

3

Cathartics

Phase 3

4

Neurotransmitter Agents

Phase 3

5

Laxatives

Phase 3

6

Serotonin Receptor Agonists

Phase 3

7

Serotonin

Investigational, Nutraceutical

Phase 3

50-67-9

5202

8

Rifaximin

Approved, Investigational

Phase 2

80621-81-4

46783403 6436173

9

Pharmaceutical Solutions

Phase 2

10

Anti-Bacterial Agents

Phase 2

11

Anti-Infective Agents

Phase 2

Interventional clinical trials:

(show all 19)

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of Prucalopride in Critically Ill Patients With Paralytic Ileus; a Pilot Randomized Double-blind Controlled Trial	Unknown status	NCT04190173	Phase 3	Prucalopride;Placebo
2	The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean Section: Randomized Controlled Trial	Completed	NCT01131416	Phase 2, Phase 3
3	Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer: a Randomized Controlled Trial	Withdrawn	NCT01389986	Phase 2, Phase 3
4	Effect of Daikenchuto (TJ-100) on Intestinal Dysmotility and For the Prevention of Postoperative Paralytic Ileus in Patients Undergoing Pancreaticoduodenectomy: A Multicenter, Randomized, Placebo-Controlled Phase II Trial	Unknown status	NCT01607307	Phase 2	Oral/enteral TJ-100 solution;Oral/enteral placebo solution
5	A Double-Blind, Placebo-Controlled, Cross-Over, Multiple (n=1) Trial to Evaluate the Effects of R093877 in Patients With Chronic Intestinal Pseudo-Obstruction (CIP).	Completed	NCT00793247	Phase 2	PRU-PLA-PRU-PLA;PLA-PRU-PLA-PRU;PLA-PRU-PRU-PLA;PRU-PLA-PLA-PRU
6	Efficacy and Safety of Rifaximin for Patients With Chronic Intestinal Pseudo-obstruction: a Single Center, Randomized, Placebo Controlled, Double-blind Phase 2 Trial	Active, not recruiting	NCT04118699	Phase 2	Rifaximin oral tablet;Placebo oral tablet
7	Acupuncture to Prevent Postoperative Paralytic Ileus	Terminated	NCT00065234	Phase 2
8	Effects of Laser Acupuncture Therapy on Paralytic Ileus	Unknown status	NCT03041675
9	Gum Chewing Reduces the Risk of Postoperative Ileus After Arthroplasty Procedures in The Elderly Population: A Parallel Design, Open-Label, Randomized Controlled Trial	Unknown status	NCT04489875
10	Diagnostic Accuracy of Increased Serum Cytokine Levels as a Marker of Paralytic Ileus Following Robotic Radical Cystectomy	Unknown status	NCT03982498
11	Efficacy and Safety of Fecal Microbiota Transplantation in Treatment of Chronic Intestinal Pseudo-obstruction: a Preliminary Study	Completed	NCT02731183
12	Randomized Controlled Trial of Rib Raising as Early Treatment for Post-operative Ileus	Completed	NCT03662672
13	The Effect of Postoperative Chewing Gum on Intestinal Functions After Gynecological Laparoscopic Surgery	Completed	NCT03884244
14	Effectiveness of Gum Chewing on Reduction of Postoperative Paralytic Ileus for Chinese Colorectal Cancer Patients Underwent Laparoscopic Colorectal Surgery and Enhanced Recovery Program	Completed	NCT02419586
15	A Case-control Study of the Gastrointestinal Response to a Liquid Test Meal in Chronic Intestinal Pseudo-obstruction, Using Magnetic Resonance Imaging	Recruiting	NCT04193735
16	Gastrointestinal Motility Diagnosis Registry	Recruiting	NCT04506593
17	Improved Quality of Life in Children With Intestinal Failure - a Randomised Intervention Trial	Recruiting	NCT04981262
18	Coordination of Rare Diseases at Sanford	Recruiting	NCT01793168
19	The Rare Disease Clinical Research Network Natural History Study of MNGIE	Recruiting	NCT01694953

Search NIH Clinical Center for Intestinal Pseudo-Obstruction

Cochrane evidence based reviews: intestinal pseudo-obstruction

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Genetic Tests for Intestinal Pseudo-Obstruction

Genetic tests related to Intestinal Pseudo-Obstruction:

#	Genetic test	Affiliating Genes
1	Intestinal Pseudo-Obstruction ²⁸
2	Chronic Intestinal Pseudoobstruction ²⁸

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Anatomical Context for Intestinal Pseudo-Obstruction

Organs/tissues related to Intestinal Pseudo-Obstruction:

MalaCards : Eye, Smooth Muscle, Small Intestine, Colon, Spinal Cord, Lung, Liver

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Publications for Intestinal Pseudo-Obstruction

Articles related to Intestinal Pseudo-Obstruction:

(show top 50) (show all 3043)

#	Title	Authors	PMID	Year
1	Diagnosis of Chronic Intestinal Pseudo-obstruction and Megacystis by Sequencing the ACTG2 Gene. ⁶² ⁵	Milunsky A...Milunsky J	28422808	2017
2	Genetic screening of Congenital Short Bowel Syndrome patients confirms CLMP as the major gene involved in the recessive form of this disorder. ⁶² ⁵	Alves MM...Hofstra RM	27352967	2016
3	Variants of the ACTG2 gene correlate with degree of severity and presence of megacystis in chronic intestinal pseudo-obstruction. ⁶² ⁵	Matera I...Ceccherini I	26813947	2016
4	ACTG2 Visceral Myopathy ⁶² ⁵	Bhagwat PK...Wangler MF	26072522	2015
5	Heterozygous de novo and inherited mutations in the smooth muscle actin (ACTG2) gene underlie megacystis-microcolon-intestinal hypoperistalsis syndrome. ⁶² ⁵	Wangler MF...Beaudet A	24676022	2014
6	New Insights into the Genetics of Fetal Megacystis: ACTG2 Mutations, Encoding γ-2 Smooth Muscle Actin in Megacystis Microcolon Intestinal Hypoperistalsis Syndrome (Berdon Syndrome). ⁵	Tuzovic L...Anyane-Yeboa K	25998219	2015
7	De novo ACTG2 mutations cause congenital distended bladder, microcolon, and intestinal hypoperistalsis. ⁵	Thorson W...Tekin M	24337657	2014
8	[Intestinal pseudo-obstruction associated with polymyositis successfully treated with somatostatin analog]. ⁵³ ⁶²	Takakusaki S...Mori M	18323156	2008
9	Gastric adenocarcinoma presenting with intestinal pseudoobstruction, successfully treated with octreotide. ⁵³ ⁶²	Sharma S...Choudhuri G	17090868	2006
10	Octreotide treatment for paraneoplastic intestinal pseudo-obstruction complicating SCLC. ⁵³ ⁶²	Sorhaug S...Waldum HL	15777981	2005
11	Acute pseudo-obstruction of the small intestine following high-dose chemotherapy and stem cell support. ⁵³ ⁶²	Bauernhofer T...Samonigg H	12972700	2003
12	SOX10 mutations in chronic intestinal pseudo-obstruction suggest a complex physiopathological mechanism. ⁵³ ⁶²	Pingault V...Goossens M	12189494	2002
13	Peripheral neuropathy with hypomyelination, chronic intestinal pseudo-obstruction and deafness: a developmental "neural crest syndrome" related to a SOX10 mutation. ⁵³ ⁶²	Pingault V...Landrieu P	11026454	2000
14	Intestinal pseudo-obstruction and ischemia secondary to both beta 2-microglobulin and serum A amyloid deposition. ⁵³ ⁶²	Borczuk A...Alt E	7675780	1995
15	Intestinal pseudo-obstruction in patients with amyloidosis: clinicopathologic differences between chemical types of amyloid protein. ⁵³ ⁶²	Tada S...Fujishima M	8244111	1993
16	Gender Disparity in Surgical Device Patents: A Five-year Trend From Canada and the United States. ⁶²	Booth LE...Khosa F	36027658	2022
17	Impact of post-operative paralytic ileus on post-operative outcomes after surgery for colorectal cancer: a single-institution, retrospective study. ⁶²	Matsui R...Ishizaki Y	35429250	2022
18	Intestinal pseudo-obstruction caused by Giardia lamblia infection. ⁶²	Pessarelli T...Fraquelli M	36323453	2022
19	[Intestinal pseudo-obstruction: An infrequent manifestation of cytomegalovirus infection]. ⁶²	Eguzkiza-Ezponda L...Branas F	36253305	2022
20	Clostridium difficile colitis and peritoneal dialysis associated peritonitis: 'Difficile' treatment considerations. ⁶²	Giuliani A...Zanella M	36350040	2022
21	Intestinal pseudo-obstruction in systemic lupus erythematosus: an analysis of nationwide inpatient sample. ⁶²	Zheng J...Liu H	35819642	2022
22	Prone Transpsoas Lateral Lumbar Interbody Fusion for Degenerative Lumbar Spine Disease: Case Series With an Operative Video Using Fluoroscopy-Based Instrument Tracking Guidance. ⁶²	Soliman MAR...Pollina J	36227242	2022
23	Current pharmacotherapeutic strategies for Strongyloidiasis and the complications in its treatment. ⁶²	Buonfrate D...Watts MR	35983698	2022
24	Scientific evidence of the duration of antibiotic treatment in intra-abdominal infections with surgical focus control. ⁶²	Membrilla-Fernandez E...Sancho-Insenser JJ	35760316	2022
25	Clinical profile and management of perforation peritonitis in Bharatpur hospital, Nepal: A prospective study. ⁶²	Neupane S...Yadav KK	36268443	2022
26	Procedural outcomes of laparoscopic caudate lobe resection: A systematic review and meta-analysis. ⁶²	Hajibandeh S...Satyadas T	36245071	2022
27	The efficacy and safety of an adapted opioid-free anesthesia regimen versus conventional general anesthesia in gynecological surgery for low-resource settings: a randomized pilot study. ⁶²	Tochie JN...Minkande JZ	36280804	2022
28	Systemic lupus erythematosus following human papillomavirus vaccination: A case-based review. ⁶²	He N...Zeng X	35948863	2022
29	Intestinal pseudo-obstruction in systemic lupus erythematosus complicated by Castleman disease: a case report. ⁶²	Lan F...Zhu J	36388834	2022
30	Fecal microbiome in systemic sclerosis, in search for the best candidate for microbiota-targeted therapy for small intestinal bacterial overgrowth control. ⁶²	Fiorentini E...Bellando Randone S	36211209	2022
31	Enteric neurosphere cells injected into rectal submucosa might migrate caudorostrally to reconstitute enteric ganglia along the entire length of postnatal colon. ⁶²	Chen JC	36210457	2022
32	Exploring the Association Between Paralytic Ileus and Endoscopic Retrograde Cholangiopancreatography Complications Using the National Inpatient Sample Database. ⁶²	Wong V...Ahlawat S	36407216	2022
33	Ischemic enteritis resulting from polycythemia vera. ⁶²	Yagi S...Maeda K	35831680	2022
34	[Intestinal pseudo-obstruction: A rare presentation of congenital hypothyroidism]. ⁶²	Pena-Velez R...Gil-Vargas M	35578592	2022
35	Vitamin B12 deficiency presenting as intestinal pseudo-obstruction in short bowel syndrome: A case report. ⁶²	Morotti F...Norsa L	36435090	2022
36	Intestinal pseudo-obstruction: A rare presentation of congenital hypothyroidism. ⁶²	Pena-Velez R...Gil-Vargas M	35643919	2022
37	Implementation of Routine Endoscopy with Narrow Band Imaging in the Evaluation of Oral and Upper Airways Lesions in Oral Chronic Graft-Versus-Host Disease: A Preliminary Study. ⁶²	Nitro L...Saibene AM	36294767	2022
38	Long-term follow-up for pediatric intestinal pseudo-obstruction patients in China. ⁶²	Tang P...Wang Y	36309477	2022
39	Chronic Intestinal Pseudo-Obstruction Is Associated with Intestinal Methanogen Overgrowth. ⁶²	Khan MZ...Gabbard S	35001241	2022
40	Intestinal Pseudo-Obstruction Caused by Bilateral Medial Medullary Infarction. ⁶²	Xia C	36352679	2022
41	Massive colothorax secondary to intestinal pseudo-obstruction: an unusual cause of respiratory failure. ⁶²	Pippard B...Dunleavy J	35393343	2022
42	Resolution of herpes zoster-induced small bowel pseudo-obstruction by epidural nerve block: A case report. ⁶²	Lin YC...Zhou Q	36186216	2022
43	A Systematic Review and Meta-Analysis of Harmonic Scalpel Versus Conventional Techniques of Appendiceal Stump Closure in Laparoscopic Appendicectomy. ⁶²	Borkar N...Singha SK	36159348	2022
44	[A case of bromadiolone poisoning leading to digestive tract, abdominal hemorrhage and secondary paralytic ileus]. ⁶²	Chen HF...Chen L	36229221	2022
45	Effect of Reactive EGCs on Intestinal Motility and Enteric Neurons During Endotoxemia. ⁶²	Li N...Wang Q	35773377	2022
46	Paralytic Ileus Mimicking Subacute Intestinal Obstruction as a Presentation of MIS-C. ⁶²	Mukherjee D...Bharati A	35852702	2022
47	Combining BeEAM with Brentuximab Vedotin for High-Dose Therapy in CD30 Positive Lymphomas before Autologous Transplantation-A Phase I Study. ⁶²	Rausch C...Pabst T	36143025	2022
48	Interstitial Lung Disease, Intestinal Pseudo-obstruction, Biliary Tract Dilatation in a Patient with Sjogren's Syndrome. ⁶²	Mai X...Xie C	36156754	2022
49	Paralytic ileus as first symptom of Miller Fisher syndrome: A case report. ⁶²	Liu X...Zhang X	36086690	2022
50	Robotic radical distal gastrectomy for gastric cancer using the soft coagulation scissors technique. ⁶²	Yamashita Y...Miyamoto T	36169804	2022

Sources

Genes for Intestinal Pseudo-Obstruction

Genes related to Intestinal Pseudo-Obstruction (4 elite genes):

(show all 43)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	441.88	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	24337657 24676022 25998219 (more) 26072522 26813947 28422808
2	CLMP	CXADR Like Membrane Protein	Protein Coding	405.09	Pathogenic ⁵ DISEASES inferred ¹⁴	27352967
3	LOC112042785	Sharpr-MPRA Regulatory Region 9139	Functional Element	400	Pathogenic ⁵	27352967
4	TFAP2B	Transcription Factor AP-2 Beta	Protein Coding	400	Pathogenic ⁵
5	MYH11	Myosin Heavy Chain 11	Protein Coding	40.15	Likely pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
6	NDE1	NudE Neurodevelopment Protein 1	Protein Coding	25	Likely pathogenic ⁵
7	SGO1	Shugoshin 1	Protein Coding	24.36	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Summaries (show sections)
8	SOX10	SRY-Box Transcription Factor 10	Protein Coding	21.63	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12189494 11026454
9	TYMP	Thymidine Phosphorylase	Protein Coding	15.89	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
10	FLNA	Filamin A	Protein Coding	15.29	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
11	LMOD1	Leiomodin 1	Protein Coding	15.12	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	MLNR	Motilin Receptor	Protein Coding	14.97	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
13	POLG	DNA Polymerase Gamma, Catalytic Subunit	Protein Coding	14.39	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
14	RAD21	RAD21 Cohesin Complex Component	Protein Coding	14.15	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
15	TLX2	T Cell Leukemia Homeobox 2	Protein Coding	14.01	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
16	MT-TL1	Mitochondrially Encoded TRNA-Leu (UUA/G) 1	RNA Gene	13.92	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
17	EDN3	Endothelin 3	Protein Coding	13.66	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
18	EDNRB	Endothelin Receptor Type B	Protein Coding	13.61	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
19	RET	Ret Proto-Oncogene	Protein Coding	13.34	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
20	ALB	Albumin	Protein Coding	13.08	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
21	L1CAM	L1 Cell Adhesion Molecule	Protein Coding	12.86	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
22	S100B	S100 Calcium Binding Protein B	Protein Coding	12.57	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
23	SYP	Synaptophysin	Protein Coding	12.45	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
24	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	12.09	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
25	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	11.87	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
26	ATXN7	Ataxin 7	Protein Coding	11.61	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
27	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	11.31	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
28	APOB	Apolipoprotein B	Protein Coding	10.95	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
29	SST	Somatostatin	Protein Coding	10.86	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15777981 18323156 17090868
30	ACHE	Acetylcholinesterase (Cartwright Blood Group)	Protein Coding	9.61	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	12972700
31	FAS	Fas Cell Surface Death Receptor	Protein Coding	7.97	GeneCards inferred via : Publications (show sections)
32	LPAR1	Lysophosphatidic Acid Receptor 1	Protein Coding	7.97	GeneCards inferred via : Publications (show sections)
33	MT-TK	Mitochondrially Encoded TRNA-Lys (AAA/G)	RNA Gene	7.97	GeneCards inferred via : Publications (show sections)
34	PRSS1	Serine Protease 1	Protein Coding	7.97	GeneCards inferred via : Publications (show sections)
35	RUNX1	RUNX Family Transcription Factor 1	Protein Coding	7.97	GeneCards inferred via : Publications (show sections)
36	SPINK1	Serine Peptidase Inhibitor Kazal Type 1	Protein Coding	7.97	GeneCards inferred via : Publications (show sections)
37	B2M	Beta-2-Microglobulin	Protein Coding	7.7	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8244111 7675780
38	MLN	Motilin	Protein Coding	6.66	DISEASES inferred ¹⁴
39	TCAP	Titin-Cap	Protein Coding	6.17	DISEASES inferred ¹⁴
40	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	5.99	DISEASES inferred ¹⁴
41	ELAVL3	ELAV Like RNA Binding Protein 3	Protein Coding	5.94	DISEASES inferred ¹⁴
42	MYLK	Myosin Light Chain Kinase	Protein Coding	5.77	DISEASES inferred ¹⁴
43	SMTN	Smoothelin	Protein Coding	5.76	DISEASES inferred ¹⁴

Sources

Variations for Intestinal Pseudo-Obstruction

ClinVar genetic disease variations for Intestinal Pseudo-Obstruction:

⁵ (show all 12)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	TFAP2B	NM_003221.4(TFAP2B):c.602-5_606del	DEL	Pathogenic	1683496		GRCh37: GRCh38: 6:50836056-50836065
2	ACTG2	NM_001615.4(ACTG2):c.769C>T (p.Arg257Cys)	SNV	Pathogenic Pathogenic	132803	rs587777387	GRCh37: 2:74141962-74141962 GRCh38: 2:73914835-73914835
3	ACTG2	NM_001615.4(ACTG2):c.442C>A (p.Arg148Ser)	SNV	Pathogenic	132797	rs587777383	GRCh37: 2:74136257-74136257 GRCh38: 2:73909130-73909130
4	ACTG2	NM_001615.4(ACTG2):c.770G>A (p.Arg257His)	SNV	Pathogenic	208792	rs797044959	GRCh37: 2:74141963-74141963 GRCh38: 2:73914836-73914836
5	ACTG2	NM_001615.4(ACTG2):c.113G>A (p.Arg38His)	SNV	Pathogenic	217521	rs869312168	GRCh37: 2:74128551-74128551 GRCh38: 2:73901424-73901424
6	CLMP	NM_024769.5(CLMP):c.664C>T (p.Arg222Ter)	SNV	Pathogenic	50385	rs587776966	GRCh37: 11:122953808-122953808 GRCh38: 11:123083100-123083100
7	ACTG2	NM_001615.4(ACTG2):c.119G>A (p.Arg40His)	SNV	Pathogenic	132802	rs587777386	GRCh37: 2:74128557-74128557 GRCh38: 2:73901430-73901430
8	CLMP	NM_024769.5(CLMP):c.29-2A>G	SNV	Pathogenic	264668	rs879253855	GRCh37: 11:122968662-122968662 GRCh38: 11:123097954-123097954
9	CLMP, LOC112042785	NM_024769.5(CLMP):c.508C>T (p.Arg170Ter)	SNV	Pathogenic	224071	rs765907815	GRCh37: 11:122954436-122954436 GRCh38: 11:123083728-123083728
10	ACTG2	NM_001615.4(ACTG2):c.968C>T (p.Pro323Leu)	SNV	Likely Pathogenic	1047916		GRCh37: 2:74143873-74143873 GRCh38: 2:73916746-73916746
11	MYH11, NDE1	NM_001040113.2(MYH11):c.5819del (p.Pro1940fs)	DEL	Likely Pathogenic	627645	rs747392139	GRCh37: 16:15802687-15802687 GRCh38: 16:15708830-15708830
12	ACTG2	NM_001615.4(ACTG2):c.981G>T (p.Lys327Asn)	SNV	Uncertain Significance	1339480		GRCh37: 2:74143886-74143886 GRCh38: 2:73916759-73916759

Sources

Expression for Intestinal Pseudo-Obstruction

Search GEO for disease gene expression data for Intestinal Pseudo-Obstruction.

Sources

Pathways for Intestinal Pseudo-Obstruction

Pathways related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signal Transduction ⁶⁶	13.02	SGO1 RET RAD21 NDE1 MYH11 MLNR
2	Neural crest differentiation ⁷⁴	11.34	TLX2 TFAP2B SOX10
3	Smooth Muscle Contraction ⁶⁶	10.45	MYH11 LMOD1 ACTG2

Sources

GO Terms for Intestinal Pseudo-Obstruction

Biological processes related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	melanocyte differentiation	GO:0030318	9.73	SOX10 EDNRB EDN3
2	vein smooth muscle contraction	GO:0014826	9.62	EDNRB EDN3
3	neural crest cell migration	GO:0001755	9.56	SOX10 RET EDNRB EDN3
4	posterior midgut development	GO:0007497	9.46	RET EDNRB
5	regulation of biological quality	GO:0065008	9.37	EDNRB EDN3
6	enteric nervous system development	GO:0048484	9.23	TLX2 SOX10 RET EDNRB

Sources

Sources for Intestinal Pseudo-Obstruction

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

IPO MCID: INT072 MIFTS: 56	Intestinal Pseudo-Obstruction (IPO) Categories: Fetal diseases, Gastrointestinal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

Intestinal Pseudo-Obstruction (IPO)

Aliases & Classifications for Intestinal Pseudo-Obstruction

MalaCards integrated aliases for Intestinal Pseudo-Obstruction:

Characteristics:

Age Of Onset:

Classifications:

External Ids:

Summaries for Intestinal Pseudo-Obstruction

Related Diseases for Intestinal Pseudo-Obstruction

Diseases in the Intestinal Obstruction family:

Diseases related to Intestinal Pseudo-Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Intestinal Pseudo-Obstruction:

Symptoms & Phenotypes for Intestinal Pseudo-Obstruction

Human phenotypes related to Intestinal Pseudo-Obstruction:

UMLS symptoms related to Intestinal Pseudo-Obstruction:

MGI Mouse Phenotypes related to Intestinal Pseudo-Obstruction:

Drugs & Therapeutics for Intestinal Pseudo-Obstruction

Drugs for Intestinal Pseudo-Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Cochrane evidence based reviews: intestinal pseudo-obstruction

Genetic Tests for Intestinal Pseudo-Obstruction

Genetic tests related to Intestinal Pseudo-Obstruction:

Anatomical Context for Intestinal Pseudo-Obstruction

Organs/tissues related to Intestinal Pseudo-Obstruction:

Publications for Intestinal Pseudo-Obstruction

Articles related to Intestinal Pseudo-Obstruction:

Genes for Intestinal Pseudo-Obstruction

Genes related to Intestinal Pseudo-Obstruction (4 elite genes):

Variations for Intestinal Pseudo-Obstruction

ClinVar genetic disease variations for Intestinal Pseudo-Obstruction:

Expression for Intestinal Pseudo-Obstruction

Pathways for Intestinal Pseudo-Obstruction

Pathways related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

GO Terms for Intestinal Pseudo-Obstruction

Biological processes related to Intestinal Pseudo-Obstruction according to GeneCards Suite gene sharing:

Sources for Intestinal Pseudo-Obstruction