MCID: INT017
MIFTS: 47

Intestinal Schistosomiasis

Categories: Infectious diseases, Gastrointestinal diseases

Aliases & Classifications for Intestinal Schistosomiasis

MalaCards integrated aliases for Intestinal Schistosomiasis:

Name: Intestinal Schistosomiasis 12 15 73
Schistosomiasis Japonica 12 44 73
Schistosomiasis Mansoni 44 73
Katayama Fever 12 73
Schistosoma Mansoni Infectious Disease 12
Schistosoma Japonicum Infection 12
Schistosomiasis 73

Classifications:



Summaries for Intestinal Schistosomiasis

Disease Ontology : 12 A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.

MalaCards based summary : Intestinal Schistosomiasis, also known as schistosomiasis japonica, is related to strongyloidiasis and schistosomiasis. An important gene associated with Intestinal Schistosomiasis is IL13 (Interleukin 13), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Albendazole and Artemether have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and liver, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Intestinal Schistosomiasis

Diseases related to Intestinal Schistosomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 strongyloidiasis 30.6 IL13 IL5
2 schistosomiasis 29.6 CD40LG IL13 IL4 IL5 STAT6
3 malaria 28.6 CD40LG IL13 IL4 IL5
4 cytokine deficiency 10.8 IL13 IL5
5 angioimmunoblastic lymphadenopathy with dysproteinemia 10.7 IL13 IL5
6 respiratory syncytial virus infectious disease 10.7 IL13 IL5
7 paragonimiasis 10.7 IL13 IL5
8 ascaris lumbricoides infection 10.7 IL13 IL5
9 pollen allergy 10.6 IL13 IL5
10 night blindness, congenital stationary, type 1a 10.5 IL13 IL5
11 esophageal disease 10.5 IL13 IL5
12 african tick-bite fever 10.5 CD40LG IL13
13 anterior scleritis 10.5 IL5 SRCIN1
14 cough variant asthma 10.5 IL4 IL5
15 egg allergy 10.5 IL4 IL5
16 scleritis 10.4 IL4 IL5
17 eosinophilic pneumonia 10.4 IL13 IL5
18 intrinsic asthma 10.4 IL4 IL5
19 atopic keratoconjunctivitis 10.4 IL4 IL5
20 non-suppurative otitis media 10.4 IL4 IL5
21 gastrointestinal allergy 10.4 IL4 IL5
22 kimura disease 10.4 IL4 IL5
23 folliculitis 10.4 IL4 IL5
24 toxic oil syndrome 10.4 IL4 IL5
25 pustulosis palmaris et plantaris 10.3 CD40LG IL5
26 chorioretinitis 10.3 CD40LG SRCIN1
27 norwegian scabies 10.3 CD40LG IL5
28 allergic bronchopulmonary aspergillosis 10.3 IL4 IL5
29 milk allergy 10.3 IL4 IL5
30 immunoglobulin a deficiency 1 10.2 CD40LG IL4
31 congenital hypogammaglobulinemia 10.2 CD40LG IL4
32 parasitic ichthyosporea infectious disease 10.2 CD40LG IL4
33 rhinosporidiosis 10.2 CD40LG IL4
34 churg-strauss syndrome 10.2 CD40LG IL5
35 inflammatory bowel disease 4 10.2 IL13 IL4 IL5
36 angiostrongyliasis 10.2 IL13 IL4 IL5
37 apple allergy 10.2 IL13 IL4 IL5
38 latex allergy 10.2 IL13 IL4 IL5
39 immunodeficiency with hyper-igm, type 1 10.2 CD40LG IL4
40 chronic conjunctivitis 10.2 IL13 IL4 IL5
41 eosinophilic gastritis 10.2 IL13 IL4 IL5
42 chronic tic disorder 10.2 IL13 IL4 IL5
43 vernal keratoconjunctivitis 10.2 IL13 IL4 IL5
44 enterobiasis 10.2 IL13 IL4 IL5
45 buruli ulcer 10.2 CD40LG IL4
46 pulmonary eosinophilia 10.2 IL13 IL4 IL5
47 paranasal sinus disease 10.2 IL13 IL4 IL5
48 onchocerciasis 10.2 IL13 IL4 IL5
49 allergic conjunctivitis 10.2 IL13 IL4 IL5
50 nasal cavity disease 10.1 IL13 IL4 IL5

Graphical network of the top 20 diseases related to Intestinal Schistosomiasis:



Diseases related to Intestinal Schistosomiasis

Symptoms & Phenotypes for Intestinal Schistosomiasis

MGI Mouse Phenotypes related to Intestinal Schistosomiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 THBS2 IL13 IL4 IL5 ARG1 ITSN2
2 homeostasis/metabolism MP:0005376 9.92 THBS2 CHRM2 IL13 IL4 IL5 ARG1
3 immune system MP:0005387 9.8 THBS2 IL13 IL4 IL5 ARG1 STAT6
4 integument MP:0010771 9.7 CHRM2 IL13 IL4 ITSN2 STAT6 CD40LG
5 liver/biliary system MP:0005370 9.35 CHRM2 IL4 IL5 ARG1 STAT6
6 respiratory system MP:0005388 9.1 THBS2 CHRM2 IL13 IL4 IL5 STAT6

Drugs & Therapeutics for Intestinal Schistosomiasis

Drugs for Intestinal Schistosomiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 4,Not Applicable 54965-21-8 2082
2
Artemether Approved Phase 4 71963-77-4 119380 68911
3
Lumefantrine Approved Phase 4 82186-77-4 6437380
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5
Praziquantel Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 55268-74-1 4891
6 Anthelmintics Phase 4,Phase 2,Not Applicable
7 Antifungal Agents Phase 4
8 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
9 Antimalarials Phase 4
10 Antimitotic Agents Phase 4,Not Applicable
11 Antiparasitic Agents Phase 4,Phase 2,Not Applicable
12 Antiprotozoal Agents Phase 4,Not Applicable
13 Artemether-lumefantrine combination Phase 4
14 Artemisinine Phase 4
15 Artemisinins Phase 4
16
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
17 Adjuvants, Immunologic Phase 1
18 Antacids Phase 1
19 Anti-Ulcer Agents Phase 1
20 Gastrointestinal Agents Phase 1
21 Vaccines Phase 1
22
Citric Acid Approved, Nutraceutical, Vet_approved Not Applicable 77-92-9 311
23 Mango Approved, Nutraceutical Not Applicable
24
Vitamin C Approved, Nutraceutical Not Applicable 50-81-7 5785 54670067
25 Trichostatin A Not Applicable
26 Vitamins Not Applicable
27 Citrate Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Artemisinin-based Combination Therapy-Intermittent Preventive Treatment (ACT-IPT) Trial Among Schoolchildren in Kassena-Nankana, Ghana Unknown status NCT01459146 Phase 4 Artemether-lumefantrine combination plus albendazole;Artemether-lumefantrine plus Praziquantel plus Albendazole;Albendazole plus Praziquantel
2 Schistosoma Mansoni Morbidity in Children Aged 1-5 Years Completed NCT01901484 Phase 2 Praziquantel
3 A Phase I Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel® With or Without GLA-AF for Intestinal Schistosomiasis in Healthy Adults Completed NCT02337855 Phase 1
4 A Phase Ib Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel)(R) With or Without AP 10-701 for Intestinal Schistosomiasis in Healthy Exposed Adults Recruiting NCT03110757 Phase 1
5 Evaluation of Strategies for Improved Uptake of Preventive Treatment for Intestinal Schistosomiasis Unknown status NCT01869465 Not Applicable
6 A Study of Co-infections of HIV-1 and Schistosoma Mansoni and Its Impact on Praziquantel Treatment Outcomes Unknown status NCT01541631 Not Applicable Praziquantel and Albendazole;Praziquantel and Albendazole;Praziquantel and Albendazole

Search NIH Clinical Center for Intestinal Schistosomiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: schistosomiasis japonica

Genetic Tests for Intestinal Schistosomiasis

Anatomical Context for Intestinal Schistosomiasis

MalaCards organs/tissues related to Intestinal Schistosomiasis:

41
Colon, Testes, Liver, B Cells, Appendix, Skin

Publications for Intestinal Schistosomiasis

Articles related to Intestinal Schistosomiasis:

(show top 50) (show all 131)
# Title Authors Year
1
Capacity gaps in health facilities for case management of intestinal schistosomiasis and soil-transmitted helminthiasis in Burundi. ( 29970181 )
2018
2
Study of diagnostic accuracy of Helmintex, Kato-Katz, and POC-CCA methods for diagnosing intestinal schistosomiasis in Candeal, a low intensity transmission area in northeastern Brazil. ( 29518081 )
2018
3
Intestinal Schistosomiasis: A Rare Cause of Abdominal Pain and Weight loss. ( 29560299 )
2018
4
Evaluation of diagnostic methods for the detection of intestinal schistosomiasis in endemic areas with low parasite loads: Saline gradient, Helmintex, Kato-Katz and rapid urine test. ( 29470516 )
2018
5
Under diagnosis of intestinal schistosomiasis in a referral hospital, North Ethiopia. ( 29661251 )
2018
6
Surveillance of intestinal schistosomiasis during control: a comparison of four diagnostic tests across five Ugandan primary schools in the Lake Albert region. ( 29560841 )
2018
7
Intestinal schistosomiasis in Uganda at high altitude (>1400A m): malacological and epidemiological surveys on Mount Elgon and in Fort Portal crater lakes reveal extra preventive chemotherapy needs. ( 28162096 )
2017
8
Knowledge, attitude, and practices on intestinal schistosomiasis among primary schoolchildren in the Lake Victoria basin, Rorya District, north-western Tanzania. ( 28934944 )
2017
9
Coinfection of intestinal schistosomiasis and malaria and association with haemoglobin levels and nutritional status in school children in Mara region, Northwestern Tanzania: a cross-sectional exploratory study. ( 29121978 )
2017
10
The Problem with Diagnosis of Intestinal Schistosomiasis. ( 29033139 )
2017
11
Colorectal cancer in a patient with intestinal schistosomiasis: a case report from Kilimanjaro Christian Medical Center Northern Zone Tanzania. ( 28768520 )
2017
12
Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy. ( 27507822 )
2016
13
Intestinal Schistosomiasis among Primary Schoolchildren in Two On-Shore Communities in Rorya District, Northwestern Tanzania: Prevalence, Intensity of Infection and Associated Risk Factors. ( 27822385 )
2016
14
An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda. ( 27864517 )
2016
15
LOW PREVALENCE OF INTESTINAL SCHISTOSOMIASIS AMONG FISHERFOLK LIVING ALONG THE RIVER NILE IN NORTH-WESTERN UGANDA: A BIOSOCIAL INVESTIGATION. ( 27428067 )
2016
16
Arginase Activity in Peripheral Blood of Patients with Intestinal Schistosomiasis, Wonji, Central Ethiopia. ( 25786588 )
2015
17
Environmental epidemiology of intestinal schistosomiasis in Uganda: population dynamics of biomphalaria (gastropoda: planorbidae) in Lake Albert and Lake Victoria with observations on natural infections with digenetic trematodes. ( 25705680 )
2015
18
Intestinal schistosomiasis among preschool children along the shores of Lake Victoria in Uganda. ( 25454166 )
2015
19
UNDERSTANDING LOW UPTAKE OF MASS TREATMENT FOR INTESTINAL SCHISTOSOMIASIS AMONG SCHOOL CHILDREN: A QUALITATIVE STUDY IN JINJA DISTRICT, UGANDA. ( 24735860 )
2014
20
Intestinal schistosomiasis and geohelminths of Ukara Island, North-Western Tanzania: prevalence, intensity of infection and associated risk factors among school children. ( 25533267 )
2014
21
Simultaneous giant mucinous cystadenoma of the appendix and intestinal schistosomiasis: 'case report and brief review'. ( 25518977 )
2014
22
Intestinal schistosomiasis in pre school-aged children of Lake Albert, Uganda: diagnostic accuracy of a rapid test for detection of anti-schistosome antibodies. ( 23976783 )
2013
23
The urine circulating cathodic antigen (CCA) dipstick: a valid substitute for microscopy for mapping and point-of-care diagnosis of intestinal schistosomiasis. ( 23359826 )
2013
24
Environmental epidemiology of intestinal schistosomiasis and genetic diversity of Schistosoma mansoni infections in snails at Bugoigo village, Lake Albert. ( 23085327 )
2013
25
Biophysical and formulation studies of the Schistosoma mansoni TSP-2 extracellular domain recombinant protein, a lead vaccine candidate antigen for intestinal schistosomiasis. ( 23880663 )
2013
26
Hepatic and intestinal schistosomiasis: review. ( 25685451 )
2013
27
Intestinal schistosomiasis in chimpanzees on Ngamba Island, Uganda: observations on liver fibrosis, schistosome genetic diversity and praziquantel treatment. ( 23095137 )
2013
28
Uptake of preventive treatment for intestinal schistosomiasis among school children in Jinja district, Uganda: a cross sectional study. ( 23667617 )
2013
29
Micro-scale investigation of intestinal schistosomiasis transmission on Ngamba and Kimi islands, Lake Victoria, Uganda. ( 22381896 )
2013
30
Large-scale determinants of intestinal schistosomiasis and intermediate host snail distribution across Africa: does climate matter? ( 22142789 )
2013
31
Expression at a 20L scale and purification of the extracellular domain of the Schistosoma mansoni TSP-2 recombinant protein: A vaccine candidate for human intestinal schistosomiasis. ( 23899507 )
2013
32
Endoscopic characteristics and causes of misdiagnosis of intestinal schistosomiasis. ( 23969514 )
2013
33
Notes on the use of urine-CCA dipsticks for detection of intestinal schistosomiasis in preschool children. ( 22858241 )
2012
34
Intestinal schistosomiasis as unusual aetiology for acute appendicitis, nowadays a rising disease in Western countries. ( 22792502 )
2012
35
Patterns of intestinal schistosomiasis among mothers and young children from Lake Albert, Uganda: water contact and social networks inferred from wearable global positioning system dataloggers. ( 23242675 )
2012
36
Performance and safety of praziquantel for treatment of intestinal schistosomiasis in infants and preschool children. ( 23094120 )
2012
37
Concurrent urinary and intestinal schistosomiasis and intestinal helminthic infections in schoolchildren in Ilobu, South-western Nigeria. ( 22440198 )
2012
38
Efficacy of praziquantel syrup versus crushed praziquantel tablets in the treatment of intestinal schistosomiasis in Ugandan preschool children, with observation on compliance and safety. ( 22657533 )
2012
39
Use of fecal occult blood tests as epidemiologic indicators of morbidity associated with intestinal schistosomiasis during preventive chemotherapy in young children. ( 22927499 )
2012
40
A multicentre randomized controlled trial of the efficacy and safety of single-dose praziquantel at 40 mg/kg vs. 60 mg/kg for treating intestinal schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil. ( 21695161 )
2011
41
Impact of temperature and precipitation on propagation of intestinal schistosomiasis in an irrigated region in Ethiopia: suitability of satellite datasets. ( 21767333 )
2011
42
Combination of Kato-Katz faecal examinations and ELISA to improve accuracy of diagnosis of intestinal schistosomiasis in a low-endemic setting in Brazil. ( 20522322 )
2011
43
Field survey for strongyloidiasis in eastern Uganda with observations on efficacy of preventive chemotherapy and co-occurrence of soil-transmitted helminthiasis/intestinal schistosomiasis. ( 20961473 )
2011
44
Human intestinal schistosomiasis in communities living near three rivers of jimma town, South Western ethiopia. ( 22434990 )
2011
45
Confirmed infection with intestinal schistosomiasis in semi-captive wild-born chimpanzees on Ngamba Island, Uganda. ( 21231860 )
2011
46
Intestinal schistosomiasis in mothers and young children in Uganda: investigation of field-applicable markers of bowel morbidity. ( 21036836 )
2010
47
Impairment of intestinal barrier and secretory function as well as egg excretion during intestinal schistosomiasis occur independently of mouse mast cell protease-1. ( 20398222 )
2010
48
Performance of circulating cathodic antigen (CCA) urine-dipsticks for rapid detection of intestinal schistosomiasis in schoolchildren from shoreline communities of Lake Victoria. ( 20181101 )
2010
49
Epidemiology and control of intestinal schistosomiasis on the Sesse Islands, Uganda: integrating malacology and parasitology to tailor local treatment recommendations. ( 20663223 )
2010
50
Geographical distribution of intestinal schistosomiasis and soil-transmitted helminthiasis and preventive chemotherapy strategies in Sierra Leone. ( 21124881 )
2010

Variations for Intestinal Schistosomiasis

Expression for Intestinal Schistosomiasis

Search GEO for disease gene expression data for Intestinal Schistosomiasis.

Pathways for Intestinal Schistosomiasis

Pathways related to Intestinal Schistosomiasis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.09 CD40LG IL13 IL4 IL5 STAT6
2
Show member pathways
13.01 CD40LG IL13 IL4 IL5 SNAI1
3
Show member pathways
12.62 CD40LG IL13 IL4 IL5
4 12.56 IL13 IL4 IL5 STAT6
5
Show member pathways
12.41 IL13 IL4 IL5 STAT6
6
Show member pathways
12.18 CD40LG IL4 IL5
7
Show member pathways
12.16 IL13 IL4 IL5 STAT6
8
Show member pathways
12.08 IL13 IL4 IL5
9 11.76 IL13 IL4 STAT6
10 11.58 IL13 IL4 IL5
11 11.56 IL13 IL4 IL5
12
Show member pathways
11.51 CD40LG IL4 IL5
13 11.38 IL13 IL4 IL5
14 11.06 CD40LG IL4 IL5
15 11.03 CD40LG IL4
16 11 IL13 IL4 IL5
17 10.92 IL13 IL4 IL5 STAT6
18 10.91 IL13 IL4 IL5
19 10.82 ARG1 CD40LG IL4 IL5 STAT6
20 10.75 IL13 IL4 IL5

GO Terms for Intestinal Schistosomiasis

Cellular components related to Intestinal Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 ARG1 CD40LG IL13 IL4 IL5 THBS2

Biological processes related to Intestinal Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.67 CD40LG IL13 IL4 IL5
2 regulation of signaling receptor activity GO:0010469 9.62 CD40LG IL13 IL4 IL5
3 cytokine-mediated signaling pathway GO:0019221 9.56 IL13 IL4 IL5 STAT6
4 negative regulation of endothelial cell apoptotic process GO:2000352 9.4 IL13 IL4
5 positive regulation of isotype switching to IgE isotypes GO:0048295 9.16 IL4 STAT6
6 negative regulation of complement-dependent cytotoxicity GO:1903660 8.96 IL13 IL4
7 positive regulation of B cell proliferation GO:0030890 8.8 IL13 IL4 IL5

Molecular functions related to Intestinal Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 8.96 IL13 IL4
2 cytokine activity GO:0005125 8.92 CD40LG IL13 IL4 IL5

Sources for Intestinal Schistosomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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