MCID: INT017
MIFTS: 50

Intestinal Schistosomiasis

Categories: Blood diseases, Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Intestinal Schistosomiasis

MalaCards integrated aliases for Intestinal Schistosomiasis:

Name: Intestinal Schistosomiasis 12 15 74
Schistosomiasis Japonica 12 45 17 74
Schistosomiasis Mansoni 45 17 74
Katayama Fever 12 74
Schistosoma Mansoni Infectious Disease 12
Schistosoma Japonicum Infection 12
Schistosomiasis 74

Classifications:



Summaries for Intestinal Schistosomiasis

Disease Ontology : 12 A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.

MalaCards based summary : Intestinal Schistosomiasis, also known as schistosomiasis japonica, is related to schistosomiasis and cytokine deficiency. An important gene associated with Intestinal Schistosomiasis is IL13 (Interleukin 13), and among its related pathways/superpathways are Pathways in cancer and Th17 cell differentiation. The drugs Albendazole and Lumefantrine have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and colon, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 77 Schistosoma mansoni is a water-borne parasite of humans, and belongs to the group of blood flukes... more...

Related Diseases for Intestinal Schistosomiasis

Diseases related to Intestinal Schistosomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 31.1 ARG1 IL13 IL4 IL5 STAT6
2 cytokine deficiency 30.7 IL13 IL5
3 paragonimiasis 30.4 IL13 IL5
4 ascaris lumbricoides infection 30.4 IL13 IL5
5 cercarial dermatitis 30.4 IL5 SNAI1
6 strongyloidiasis 30.2 IL13 IL5
7 tetanus 30.0 IL13 IL4 IL5
8 hypereosinophilic syndrome 30.0 IL13 IL4 IL5
9 urinary schistosomiasis 29.4 IL13 IL4 IL5 STAT6
10 asthma 29.1 ARG1 IL13 IL4 IL5 STAT6
11 parasitic helminthiasis infectious disease 28.4 CHRM2 IL13 IL4 IL5 ITSN2 MT-ND1
12 hepatocellular carcinoma 10.4
13 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL13 IL5
14 respiratory syncytial virus infectious disease 10.3 IL13 IL5
15 portal hypertension 10.3
16 schistosoma mansoni infection, susceptibility/ 10.3
17 esophagitis, eosinophilic, 1 10.3 IL13 IL5
18 joint disorders 10.3
19 arthropathy 10.3
20 splenomegaly 10.3
21 radiculopathy 10.3 IL13 IL5
22 pollen allergy 10.2 IL13 IL5
23 intestinal volvulus 10.2 IL5 SRCIN1
24 salmonellosis 10.2
25 nephrotic syndrome 10.2
26 night blindness, congenital stationary, type 1a 10.2 IL13 IL5
27 hepatitis 10.2
28 cough variant asthma 10.2 IL4 IL5
29 scleritis 10.2 IL4 IL5
30 egg allergy 10.2 IL4 IL5
31 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 IL13 IL5
32 sulfamethoxazole allergy 10.2 IL4 IL5
33 anterior scleritis 10.2 IL5 SRCIN1
34 atopic keratoconjunctivitis 10.2 IL4 IL5
35 intrinsic asthma 10.2 IL4 IL5
36 trichinosis 10.2 IL4 IL5
37 gaucher disease, type ii 10.2 IL4 IL5
38 eosinophilic pneumonia 10.2 IL13 IL5
39 non-suppurative otitis media 10.2 IL4 IL5
40 kimura disease 10.2 IL4 IL5
41 mycoplasma pneumoniae pneumonia 10.2 IL13 IL4
42 toxic oil syndrome 10.1 IL4 IL5
43 folliculitis 10.1 IL4 IL5
44 varicose veins 10.1
45 thrombocytopenia 10.1
46 diverticulitis 10.1
47 meckel's diverticulitis 10.1
48 collagen disease 10.1
49 toxoplasmosis 10.1
50 hepatitis b 10.1

Graphical network of the top 20 diseases related to Intestinal Schistosomiasis:



Diseases related to Intestinal Schistosomiasis

Symptoms & Phenotypes for Intestinal Schistosomiasis

MGI Mouse Phenotypes related to Intestinal Schistosomiasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.92 ARG1 CHRM2 IL13 IL4 IL5 ITSN2
2 hematopoietic system MP:0005397 9.91 ARG1 IL13 IL4 IL5 ITSN2 STAT6
3 integument MP:0010771 9.73 CHRM2 IL13 IL4 ITSN2 STAT6 THBS2
4 nervous system MP:0003631 9.56 ARG1 CHRM2 IL13 IL4 ITSN2 SNAI1
5 liver/biliary system MP:0005370 9.55 ARG1 CHRM2 IL4 IL5 STAT6
6 respiratory system MP:0005388 9.1 CHRM2 IL13 IL4 IL5 STAT6 THBS2

Drugs & Therapeutics for Intestinal Schistosomiasis

Drugs for Intestinal Schistosomiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 4,Not Applicable 54965-21-8 2082
2
Lumefantrine Approved Phase 4 82186-77-4 6437380
3
Artemether Approved Phase 4 71963-77-4 68911 119380
4
Praziquantel Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 55268-74-1 4891
5 Antimitotic Agents Phase 4,Not Applicable
6 Antiparasitic Agents Phase 4,Phase 2,Not Applicable
7 Anthelmintics Phase 4,Phase 2,Not Applicable
8 Antiprotozoal Agents Phase 4,Not Applicable
9 Artemisinine Phase 4
10 Artemisinins Phase 4
11 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
12 Artemether, Lumefantrine Drug Combination Phase 4
13 Antimalarials Phase 4
14
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
15 Gastrointestinal Agents Phase 1
16 Adjuvants, Immunologic Phase 1
17 Vaccines Phase 1
18 Antacids Phase 1
19 Anti-Ulcer Agents Phase 1
20 Immunologic Factors Phase 1
21 Mango Approved Not Applicable
22
Sodium Citrate Approved, Investigational Not Applicable 68-04-2
23
Vitamin C Approved, Nutraceutical Not Applicable 50-81-7 54670067 5785
24
Citric Acid Approved, Nutraceutical, Vet_approved Not Applicable 77-92-9 311
25 Vitamins Not Applicable
26 Trichostatin A Not Applicable
27 Citrate Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Artemisinin-based Combination Therapy-Intermittent Preventive Treatment (ACT-IPT) Trial Among Schoolchildren in Kassena-Nankana, Ghana Unknown status NCT01459146 Phase 4 Artemether-lumefantrine combination plus albendazole;Artemether-lumefantrine plus Praziquantel plus Albendazole;Albendazole plus Praziquantel
2 Schistosoma Mansoni Morbidity in Children Aged 1-5 Years Completed NCT01901484 Phase 2 Praziquantel
3 Praziquantel in Children Under Age 4 Not yet recruiting NCT03640377 Phase 2 Praziquantel
4 A Phase I Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel® With or Without GLA-AF for Intestinal Schistosomiasis in Healthy Adults Completed NCT02337855 Phase 1
5 A Phase Ib Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel)(R) With or Without AP 10-701 for Intestinal Schistosomiasis in Healthy Exposed Adults Active, not recruiting NCT03110757 Phase 1
6 Evaluation of Strategies for Improved Uptake of Preventive Treatment for Intestinal Schistosomiasis Unknown status NCT01869465 Not Applicable
7 A Study of Co-infections of HIV-1 and Schistosoma Mansoni and Its Impact on Praziquantel Treatment Outcomes Unknown status NCT01541631 Not Applicable Praziquantel and Albendazole;Praziquantel and Albendazole;Praziquantel and Albendazole
8 Validation of POC-CCA Rapid Urine Test for Qualitative Detection of Schistosoma Japonicum Not yet recruiting NCT03870204

Search NIH Clinical Center for Intestinal Schistosomiasis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: schistosomiasis japonica

Genetic Tests for Intestinal Schistosomiasis

Anatomical Context for Intestinal Schistosomiasis

MalaCards organs/tissues related to Intestinal Schistosomiasis:

42
Liver, Testes, Colon, T Cells, Skin, B Cells, Appendix

Publications for Intestinal Schistosomiasis

Articles related to Intestinal Schistosomiasis:

(show top 50) (show all 586)
# Title Authors Year
1
A case of acute appendicitis due to intestinal schistosomiasis. ( 30555690 )
2019
2
Biomphalaria pfeifferi Snails and Intestinal Schistosomiasis, Lake Malawi, Africa, 2017-2018. ( 30602122 )
2019
3
Intestinal schistosomiasis: a very long-lived tropical parasite. ( 30797063 )
2019
4
Non-invasive surveillance of Plasmodium infection by real-time PCR analysis of ethanol preserved faeces from Ugandan school children with intestinal schistosomiasis. ( 30935388 )
2019
5
Comparison of Kato Katz, antibody-based ELISA and droplet digital PCR diagnosis of schistosomiasis japonica: Lessons learnt from a setting of low infection intensity. ( 30830925 )
2019
6
Distribution pattern of the snail intermediate host of schistosomiasis japonica in the Poyang Lake region of China. ( 30922403 )
2019
7
Reversal of liver fibrosis after splenectomy in a patient with advanced schistosomiasis japonica: A case report with 4-year follow-up. ( 30973870 )
2019
8
Evaluation of diagnostic methods for the detection of intestinal schistosomiasis in endemic areas with low parasite loads: Saline gradient, Helmintex, Kato-Katz and rapid urine test. ( 29470516 )
2018
9
Study of diagnostic accuracy of Helmintex, Kato-Katz, and POC-CCA methods for diagnosing intestinal schistosomiasis in Candeal, a low intensity transmission area in northeastern Brazil. ( 29518081 )
2018
10
Intestinal Schistosomiasis: A Rare Cause of Abdominal Pain and Weight loss. ( 29560299 )
2018
11
Surveillance of intestinal schistosomiasis during control: a comparison of four diagnostic tests across five Ugandan primary schools in the Lake Albert region. ( 29560841 )
2018
12
Under diagnosis of intestinal schistosomiasis in a referral hospital, North Ethiopia. ( 29661251 )
2018
13
Capacity gaps in health facilities for case management of intestinal schistosomiasis and soil-transmitted helminthiasis in Burundi. ( 29970181 )
2018
14
Analysis of risk factors and changing trends the infection rate of intestinal schistosomiasis caused by S. japonicum from 2005 to 2014 in Lushan city. ( 30055333 )
2018
15
Estimating the prevalence of schistosomiasis japonica in China: a serological approach. ( 29961423 )
2018
16
The regulation of regulation: interleukin-10 increases CD4+ CD25+ regulatory T cells but impairs their immunosuppressive activity in murine models with schistosomiasis japonica or asthma. ( 28799262 )
2018
17
Toxoplasma gondii GRA15II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica. ( 27157496 )
2018
18
Evaluation of transient elastography in assessing liver fibrosis in patients with advanced schistosomiasis japonica. ( 29355611 )
2018
19
Effect of miR-182 on hepatic fibrosis induced by Schistosomiasis japonica by targeting FOXO1 through PI3K/AKT signaling pathway. ( 29323718 )
2018
20
Intestinal schistosomiasis in Uganda at high altitude (>1400 m): malacological and epidemiological surveys on Mount Elgon and in Fort Portal crater lakes reveal extra preventive chemotherapy needs. ( 28162096 )
2017
21
Colorectal cancer in a patient with intestinal schistosomiasis: a case report from Kilimanjaro Christian Medical Center Northern Zone Tanzania. ( 28768520 )
2017
22
Knowledge, attitude, and practices on intestinal schistosomiasis among primary schoolchildren in the Lake Victoria basin, Rorya District, north-western Tanzania. ( 28934944 )
2017
23
The Problem with Diagnosis of Intestinal Schistosomiasis. ( 29033139 )
2017
24
Coinfection of intestinal schistosomiasis and malaria and association with haemoglobin levels and nutritional status in school children in Mara region, Northwestern Tanzania: a cross-sectional exploratory study. ( 29121978 )
2017
25
A Parallel Comparison of Antigen Candidates for Development of an Optimized Serological Diagnosis of Schistosomiasis Japonica in the Philippines. ( 28943229 )
2017
26
Schistosomiasis Japonica Control in Domestic Animals: Progress and Experiences in China. ( 29312176 )
2017
27
A candidate recombinant antigen for diagnosis of schistosomiasis japonica in domestic animals. ( 28807301 )
2017
28
A cross-sectional survey comparing a free treatment program for advanced schistosomiasis japonica to a general assistance program. ( 28884235 )
2017
29
Comparative analysis of knowledge on schistosomiasis japonica in the local people in the former endemic area in Yamanashi Prefecture, Japan: comparisons among the background of age and occupation. ( 28111404 )
2017
30
A novel duplex ddPCR assay for the diagnosis of schistosomiasis japonica: proof of concept in an experimental mouse model. ( 28274280 )
2017
31
Lessons from a 15-year-old boy with advanced schistosomiasis japonica in China: a case report. ( 28508167 )
2017
32
Plasma D-dimer Can Effectively Predict the Prospective Occurrence of Ascites in Advanced Schistosomiasis Japonica Patients. ( 28506039 )
2017
33
A novel colloidal gold immunochromatography assay strip for the diagnosis of schistosomiasis japonica in domestic animals. ( 28388965 )
2017
34
An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda. ( 27864517 )
2016
35
LOW PREVALENCE OF INTESTINAL SCHISTOSOMIASIS AMONG FISHERFOLK LIVING ALONG THE RIVER NILE IN NORTH-WESTERN UGANDA: A BIOSOCIAL INVESTIGATION. ( 27428067 )
2016
36
Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy. ( 27507822 )
2016
37
Intestinal Schistosomiasis among Primary Schoolchildren in Two On-Shore Communities in Rorya District, Northwestern Tanzania: Prevalence, Intensity of Infection and Associated Risk Factors. ( 27822385 )
2016
38
Short-Term Efficacy of Laparoscopic Treatment for Colorectal Cancer in Patients with Schistosomiasis Japonica. ( 27843449 )
2016
39
Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica. ( 26812024 )
2016
40
Assessment of the effect of treatment and assistance program on advanced patients with schistosomiasis japonica in China from 2009 to 2014. ( 27461114 )
2016
41
Saposin-like Proteins, a Multigene Family of Schistosoma Species, are Biomarkers for the Immunodiagnosis of Schistosomiasis Japonica. ( 27190177 )
2016
42
Towards the Elimination of Schistosomiasis japonica through Control of the Disease in Domestic Animals in The People's Republic of China: A Tale of over 60Years. ( 27137450 )
2016
43
Blockade of PD-1 Signaling Enhances Th2 Cell Responses and Aggravates Liver Immunopathology in Mice with Schistosomiasis japonica. ( 27792733 )
2016
44
Understanding low uptake of mass treatment for intestinal schistosomiasis among school children: a qualitative study in Jinja district, Uganda. ( 24735860 )
2015
45
Intestinal schistosomiasis among preschool children along the shores of Lake Victoria in Uganda. ( 25454166 )
2015
46
Environmental epidemiology of intestinal schistosomiasis in Uganda: population dynamics of biomphalaria (gastropoda: planorbidae) in Lake Albert and Lake Victoria with observations on natural infections with digenetic trematodes. ( 25705680 )
2015
47
Arginase activity in peripheral blood of patients with intestinal schistosomiasis, Wonji, Central Ethiopia. ( 25786588 )
2015
48
Lack of IL-17 signaling decreases liver fibrosis in murine schistosomiasis japonica. ( 25840437 )
2015
49
Vaccines and diagnostics for zoonotic schistosomiasis japonica. ( 25359506 )
2015
50
Research and control of advanced schistosomiasis japonica in China. ( 25403379 )
2015

Variations for Intestinal Schistosomiasis

Expression for Intestinal Schistosomiasis

Search GEO for disease gene expression data for Intestinal Schistosomiasis.

Pathways for Intestinal Schistosomiasis

Pathways related to Intestinal Schistosomiasis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1 12.55 IL13 IL4 IL5 STAT6
2
Show member pathways
12.33 IL13 IL4 IL5 STAT6
3
Show member pathways
12.14 IL13 IL4 IL5 STAT6
4
Show member pathways
12.07 IL13 IL4 IL5
5 11.74 IL13 IL4 STAT6
6 11.55 IL13 IL4 IL5
7 11.51 IL13 IL4 IL5
8 11.43 ARG1 IL13 IL4
9 11.34 IL13 IL4 IL5
10 11.26 IL13 IL4
11 11.07 IL4 IL5
12 11.06 ARG1 IL4 IL5 STAT6
13 11 IL13 IL4 IL5
14 10.94 IL13 IL4 IL5
15 10.9 IL13 IL4 IL5
16 10.75 IL13 IL4 IL5
17 10.59 IL13 IL4 IL5 STAT6

GO Terms for Intestinal Schistosomiasis

Cellular components related to Intestinal Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 8.92 ARG1 CHRM2 MT-ND1 SRCIN1

Biological processes related to Intestinal Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.56 IL13 IL4 IL5 STAT6
2 positive regulation of cold-induced thermogenesis GO:0120162 9.5 IL13 IL4 STAT6
3 negative regulation of endothelial cell apoptotic process GO:2000352 9.37 IL13 IL4
4 negative regulation of complement-dependent cytotoxicity GO:1903660 9.16 IL13 IL4
5 positive regulation of isotype switching to IgE isotypes GO:0048295 8.96 IL4 STAT6
6 positive regulation of B cell proliferation GO:0030890 8.8 IL13 IL4 IL5

Molecular functions related to Intestinal Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL13 IL4 IL5
2 cytokine receptor binding GO:0005126 8.62 IL13 IL4

Sources for Intestinal Schistosomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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