MCID: INT017
MIFTS: 50

Intestinal Schistosomiasis

Categories: Blood diseases, Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Intestinal Schistosomiasis

MalaCards integrated aliases for Intestinal Schistosomiasis:

Name: Intestinal Schistosomiasis 12 15 73
Schistosomiasis Japonica 12 44 73
Schistosomiasis Mansoni 44 73
Katayama Fever 12 73
Schistosoma Mansoni Infectious Disease 12
Schistosoma Japonicum Infection 12
Schistosomiasis 73

Classifications:



Summaries for Intestinal Schistosomiasis

Disease Ontology : 12 A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.

MalaCards based summary : Intestinal Schistosomiasis, also known as schistosomiasis japonica, is related to schistosomiasis and cercarial dermatitis. An important gene associated with Intestinal Schistosomiasis is IL13 (Interleukin 13), and among its related pathways/superpathways are Pathways in cancer and Th17 cell differentiation. The drugs Lumefantrine and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and liver, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 76 Schistosoma mansoni is a water-borne parasite of humans, and belongs to the group of blood flukes... more...

Related Diseases for Intestinal Schistosomiasis

Diseases related to Intestinal Schistosomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 31.4 ARG1 IL13 IL4 IL5 STAT6
2 cercarial dermatitis 30.3 IL5 SNAI1
3 paragonimiasis 30.3 IL13 IL5
4 strongyloidiasis 30.0 IL13 IL5
5 urinary schistosomiasis 29.6 IL13 IL4 IL5 STAT6
6 asthma 29.4 ARG1 IL13 IL4 IL5 STAT6
7 hepatocellular carcinoma 10.4
8 portal hypertension 10.3
9 schistosoma mansoni infection, susceptibility/ 10.3
10 cytokine deficiency 10.2 IL13 IL5
11 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL13 IL5
12 arthropathy 10.2
13 respiratory syncytial virus infectious disease 10.2 IL13 IL5
14 hepatitis 10.2
15 ascaris lumbricoides infection 10.2 IL13 IL5
16 pollen allergy 10.2 IL13 IL5
17 intestinal volvulus 10.1 IL5 SRCIN1
18 thrombocytopenia 10.1
19 salmonellosis 10.1
20 diverticulitis 10.1
21 meckel's diverticulitis 10.1
22 collagen disease 10.1
23 cough variant asthma 10.1 IL4 IL5
24 night blindness, congenital stationary, type 1a 10.1 IL13 IL5
25 scleritis 10.1 IL4 IL5
26 egg allergy 10.1 IL4 IL5
27 sulfamethoxazole allergy 10.1 IL4 IL5
28 anterior scleritis 10.1 IL5 SRCIN1
29 atopic keratoconjunctivitis 10.1 IL4 IL5
30 hepatitis b 10.1
31 gaucher disease, type ii 10.1 IL4 IL5
32 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 IL13 IL5
33 intrinsic asthma 10.1 IL4 IL5
34 trichinosis 10.1 IL4 IL5
35 cryoglobulinemia, familial mixed 10.1
36 porphyria cutanea tarda, type i 10.1
37 porphyria cutanea tarda 10.1
38 glomerulonephritis 10.1
39 porphyria 10.1
40 squamous cell carcinoma 10.1
41 cryoglobulinemia 10.1
42 immune-complex glomerulonephritis 10.1
43 amyloidosis 10.1
44 eosinophilic pneumonia 10.1 IL13 IL5
45 non-suppurative otitis media 10.1 IL4 IL5
46 kimura disease 10.1 IL4 IL5
47 toxic oil syndrome 10.1 IL4 IL5
48 mycoplasma pneumoniae pneumonia 10.1 IL13 IL4
49 folliculitis 10.1 IL4 IL5
50 allergic bronchopulmonary aspergillosis 10.1 IL4 IL5

Graphical network of the top 20 diseases related to Intestinal Schistosomiasis:



Diseases related to Intestinal Schistosomiasis

Symptoms & Phenotypes for Intestinal Schistosomiasis

MGI Mouse Phenotypes related to Intestinal Schistosomiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 ARG1 CHRM2 IL13 IL4 IL5 ITSN2
2 hematopoietic system MP:0005397 10.01 ARG1 IL13 IL4 IL5 ITSN2 PRDX2
3 immune system MP:0005387 9.87 ARG1 IL13 IL4 IL5 PRDX2 STAT6
4 integument MP:0010771 9.73 CHRM2 IL13 IL4 ITSN2 STAT6 THBS2
5 nervous system MP:0003631 9.56 ARG1 CHRM2 IL13 IL4 ITSN2 SNAI1
6 liver/biliary system MP:0005370 9.55 ARG1 CHRM2 IL4 IL5 STAT6
7 respiratory system MP:0005388 9.1 CHRM2 IL13 IL4 IL5 STAT6 THBS2

Drugs & Therapeutics for Intestinal Schistosomiasis

Drugs for Intestinal Schistosomiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lumefantrine Approved Phase 4 82186-77-4 6437380
2
Albendazole Approved, Vet_approved Phase 4,Not Applicable 54965-21-8 2082
3
Artemether Approved Phase 4 71963-77-4 119380 68911
4
Praziquantel Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 55268-74-1 4891
5
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
6 Antiprotozoal Agents Phase 4,Not Applicable
7 Anthelmintics Phase 4,Phase 2,Not Applicable
8 Antimitotic Agents Phase 4,Not Applicable
9 Antiparasitic Agents Phase 4,Phase 2,Not Applicable
10 Artemether-lumefantrine combination Phase 4
11 Artemisinine Phase 4
12 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
13 Antifungal Agents Phase 4
14 Antimalarials Phase 4
15 Artemisinins Phase 4
16
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
17 Antacids Phase 1
18 Immunologic Factors Phase 1
19 Anti-Ulcer Agents Phase 1
20 Adjuvants, Immunologic Phase 1
21 Vaccines Phase 1
22 Gastrointestinal Agents Phase 1
23 Mango Approved Not Applicable
24
Vitamin C Approved, Nutraceutical Not Applicable 50-81-7 5785 54670067
25
Citric Acid Approved, Nutraceutical, Vet_approved Not Applicable 77-92-9 311
26 Trichostatin A Not Applicable
27 Vitamins Not Applicable
28 Citrate Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Artemisinin-based Combination Therapy-Intermittent Preventive Treatment (ACT-IPT) Trial Among Schoolchildren in Kassena-Nankana, Ghana Unknown status NCT01459146 Phase 4 Artemether-lumefantrine combination plus albendazole;Artemether-lumefantrine plus Praziquantel plus Albendazole;Albendazole plus Praziquantel
2 Schistosoma Mansoni Morbidity in Children Aged 1-5 Years Completed NCT01901484 Phase 2 Praziquantel
3 Praziquantel in Children Under Age 4 Not yet recruiting NCT03640377 Phase 2 Praziquantel
4 A Phase I Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel® With or Without GLA-AF for Intestinal Schistosomiasis in Healthy Adults Completed NCT02337855 Phase 1
5 A Phase Ib Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel)(R) With or Without AP 10-701 for Intestinal Schistosomiasis in Healthy Exposed Adults Recruiting NCT03110757 Phase 1
6 Evaluation of Strategies for Improved Uptake of Preventive Treatment for Intestinal Schistosomiasis Unknown status NCT01869465 Not Applicable
7 A Study of Co-infections of HIV-1 and Schistosoma Mansoni and Its Impact on Praziquantel Treatment Outcomes Unknown status NCT01541631 Not Applicable Praziquantel and Albendazole;Praziquantel and Albendazole;Praziquantel and Albendazole

Search NIH Clinical Center for Intestinal Schistosomiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: schistosomiasis japonica

Genetic Tests for Intestinal Schistosomiasis

Anatomical Context for Intestinal Schistosomiasis

MalaCards organs/tissues related to Intestinal Schistosomiasis:

41
Testes, Colon, Liver, Skin, T Cells, B Cells, Appendix

Publications for Intestinal Schistosomiasis

Articles related to Intestinal Schistosomiasis:

(show top 50) (show all 505)
# Title Authors Year
1
A case of acute appendicitis due to intestinal schistosomiasis. ( 30555690 )
2019
2
Capacity gaps in health facilities for case management of intestinal schistosomiasis and soil-transmitted helminthiasis in Burundi. ( 29970181 )
2018
3
Study of diagnostic accuracy of Helmintex, Kato-Katz, and POC-CCA methods for diagnosing intestinal schistosomiasis in Candeal, a low intensity transmission area in northeastern Brazil. ( 29518081 )
2018
4
Intestinal Schistosomiasis: A Rare Cause of Abdominal Pain and Weight loss. ( 29560299 )
2018
5
Evaluation of diagnostic methods for the detection of intestinal schistosomiasis in endemic areas with low parasite loads: Saline gradient, Helmintex, Kato-Katz and rapid urine test. ( 29470516 )
2018
6
Under diagnosis of intestinal schistosomiasis in a referral hospital, North Ethiopia. ( 29661251 )
2018
7
Surveillance of intestinal schistosomiasis during control: a comparison of four diagnostic tests across five Ugandan primary schools in the Lake Albert region. ( 29560841 )
2018
8
Analysis of risk factors and changing trends the infection rate of intestinal schistosomiasis caused by S. japonicum from 2005 to 2014 in Lushan city. ( 30055333 )
2018
9
Effect of miR-182 on hepatic fibrosis induced by Schistosomiasis japonica by targeting FOXO1 through PI3K/AKT signaling pathway. ( 29323718 )
2018
10
The regulation of regulation: interleukin-10 increases CD4+ CD25+ regulatory T cells but impairs their immunosuppressive activity in murine models with schistosomiasis japonica or asthma. ( 28799262 )
2018
11
Intestinal schistosomiasis in Uganda at high altitude (>1400A m): malacological and epidemiological surveys on Mount Elgon and in Fort Portal crater lakes reveal extra preventive chemotherapy needs. ( 28162096 )
2017
12
Knowledge, attitude, and practices on intestinal schistosomiasis among primary schoolchildren in the Lake Victoria basin, Rorya District, north-western Tanzania. ( 28934944 )
2017
13
Coinfection of intestinal schistosomiasis and malaria and association with haemoglobin levels and nutritional status in school children in Mara region, Northwestern Tanzania: a cross-sectional exploratory study. ( 29121978 )
2017
14
The Problem with Diagnosis of Intestinal Schistosomiasis. ( 29033139 )
2017
15
Colorectal cancer in a patient with intestinal schistosomiasis: a case report from Kilimanjaro Christian Medical Center Northern Zone Tanzania. ( 28768520 )
2017
16
Lessons from a 15-year-old boy with advanced schistosomiasis japonica in China: a case report. ( 28508167 )
2017
17
A candidate recombinant antigen for diagnosis of schistosomiasis japonica in domestic animals. ( 28807301 )
2017
18
Schistosomiasis Japonica Control in Domestic Animals: Progress and Experiences in China. ( 29312176 )
2017
19
Comparative analysis of knowledge on schistosomiasis japonica in the local people in the former endemic area in Yamanashi Prefecture, Japan: comparisons among the background of age and occupation. ( 28111404 )
2017
20
A novel duplex ddPCR assay for the diagnosis of schistosomiasis japonica: proof of concept in an experimental mouse model. ( 28274280 )
2017
21
A novel colloidal gold immunochromatography assay strip for the diagnosis of schistosomiasis japonica in domestic animals. ( 28388965 )
2017
22
Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy. ( 27507822 )
2016
23
Intestinal Schistosomiasis among Primary Schoolchildren in Two On-Shore Communities in Rorya District, Northwestern Tanzania: Prevalence, Intensity of Infection and Associated Risk Factors. ( 27822385 )
2016
24
An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda. ( 27864517 )
2016
25
LOW PREVALENCE OF INTESTINAL SCHISTOSOMIASIS AMONG FISHERFOLK LIVING ALONG THE RIVER NILE IN NORTH-WESTERN UGANDA: A BIOSOCIAL INVESTIGATION. ( 27428067 )
2016
26
Assessment of the effect of treatment and assistance program on advanced patients with schistosomiasis japonica in China from 2009 to 2014. ( 27461114 )
2016
27
Short-Term Efficacy of Laparoscopic Treatment for Colorectal Cancer in Patients with Schistosomiasis Japonica. ( 27843449 )
2016
28
Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica. ( 26812024 )
2016
29
Arginase Activity in Peripheral Blood of Patients with Intestinal Schistosomiasis, Wonji, Central Ethiopia. ( 25786588 )
2015
30
Environmental epidemiology of intestinal schistosomiasis in Uganda: population dynamics of biomphalaria (gastropoda: planorbidae) in Lake Albert and Lake Victoria with observations on natural infections with digenetic trematodes. ( 25705680 )
2015
31
Intestinal schistosomiasis among preschool children along the shores of Lake Victoria in Uganda. ( 25454166 )
2015
32
Transcriptional profiling of chronic clinical hepatic schistosomiasis japonica indicates reduced metabolism and immune responses. ( 26216487 )
2015
33
Circulating miRNAs: Potential Novel Biomarkers for Hepatopathology Progression and Diagnosis of Schistosomiasis Japonica in Two Murine Models. ( 26230095 )
2015
34
Distribution of Peripheral Memory T Follicular Helper Cells in Patients with Schistosomiasis Japonica. ( 26284362 )
2015
35
Heat Shock Protein 60 in Eggs Specifically Induces Tregs and Reduces Liver Immunopathology in Mice with Schistosomiasis Japonica. ( 26418003 )
2015
36
Schistosomiasis japonica: modelling as a tool to explore transmission patterns. ( 25004441 )
2015
37
Elimination of schistosomiasis japonica from formerly endemic areas in mountainous regions of southern China using a praziquantel regimen. ( 25591407 )
2015
38
Spatio-temporal transmission and environmental determinants of Schistosomiasis Japonica in Anhui Province, China. ( 25659112 )
2015
39
UNDERSTANDING LOW UPTAKE OF MASS TREATMENT FOR INTESTINAL SCHISTOSOMIASIS AMONG SCHOOL CHILDREN: A QUALITATIVE STUDY IN JINJA DISTRICT, UGANDA. ( 24735860 )
2014
40
Intestinal schistosomiasis and geohelminths of Ukara Island, North-Western Tanzania: prevalence, intensity of infection and associated risk factors among school children. ( 25533267 )
2014
41
Simultaneous giant mucinous cystadenoma of the appendix and intestinal schistosomiasis: 'case report and brief review'. ( 25518977 )
2014
42
Spatio-temporal patterns of schistosomiasis japonica in lake and marshland areas in China: the effect of snail habitats. ( 24980498 )
2014
43
Activation of nuclear factor kappa B in the hepatic stellate cells of mice with schistosomiasis japonica. ( 25116007 )
2014
44
Apropos: factors impacting on progress towards elimination of transmission of schistosomiasis japonica in China. ( 25175021 )
2014
45
New uses for old drugs: the tale of artemisinin derivatives in the elimination of schistosomiasis japonica in China. ( 25244286 )
2014
46
Fine scale Spatial-temporal cluster analysis for the infection risk of Schistosomiasis japonica using space-time scan statistics. ( 25491192 )
2014
47
Field comparison of circulating antibody assays versus circulating antigen assays for the detection of schistosomiasis japonica in endemic areas of China. ( 24684924 )
2014
48
The effect of recombinant sTGFβ1RII and sIL13Rα2 receptor proteins on schistosomiasis japonica, hepatic fibrosis and signal transduction in a mouse model of schistosome disease. ( 24746639 )
2014
49
Schistosomiasis japonica during pregnancy is associated with elevated endotoxin levels in maternal and placental compartments. ( 23964108 )
2014
50
New integrated strategy emphasizing infection source control to curb Schistosomiasis japonica in a marshland area of Hubei Province, China: findings from an eight-year longitudinal survey. ( 24587030 )
2014

Variations for Intestinal Schistosomiasis

Expression for Intestinal Schistosomiasis

Search GEO for disease gene expression data for Intestinal Schistosomiasis.

Pathways for Intestinal Schistosomiasis

Pathways related to Intestinal Schistosomiasis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1 12.55 IL13 IL4 IL5 STAT6
2
Show member pathways
12.33 IL13 IL4 IL5 STAT6
3
Show member pathways
12.14 IL13 IL4 IL5 STAT6
4
Show member pathways
12.07 IL13 IL4 IL5
5 11.74 IL13 IL4 STAT6
6 11.55 IL13 IL4 IL5
7 11.51 IL13 IL4 IL5
8 11.43 ARG1 IL13 IL4
9 11.34 IL13 IL4 IL5
10 11.26 IL13 IL4
11 11.07 IL4 IL5
12 11.06 ARG1 IL4 IL5 STAT6
13 11 IL13 IL4 IL5
14 10.94 IL13 IL4 IL5
15 10.9 IL13 IL4 IL5
16 10.75 IL13 IL4 IL5
17 10.59 IL13 IL4 IL5 STAT6

GO Terms for Intestinal Schistosomiasis

Biological processes related to Intestinal Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.56 IL13 IL4 IL5 STAT6
2 positive regulation of cold-induced thermogenesis GO:0120162 9.5 IL13 IL4 STAT6
3 negative regulation of endothelial cell apoptotic process GO:2000352 9.37 IL13 IL4
4 negative regulation of complement-dependent cytotoxicity GO:1903660 9.16 IL13 IL4
5 positive regulation of isotype switching to IgE isotypes GO:0048295 8.96 IL4 STAT6
6 positive regulation of B cell proliferation GO:0030890 8.8 IL13 IL4 IL5

Molecular functions related to Intestinal Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL13 IL4 IL5
2 cytokine receptor binding GO:0005126 8.62 IL13 IL4

Sources for Intestinal Schistosomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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