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MCID: INT046
MIFTS: 39

Intestinal Tuberculosis

Categories: Gastrointestinal diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Intestinal Tuberculosis

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MalaCards integrated aliases for Intestinal Tuberculosis:

Name: Intestinal Tuberculosis 12 15
Tuberculosis of Intestines 71
Tuberculosis of Intestine 12

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13282
ICD9CM 34 014.8
UMLS 71 C0152724 C0275911
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Summaries for Intestinal Tuberculosis

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Disease Ontology : 12 A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located in intestine. The infection has symptom abdominal pain, has symptom gastrointestinal bleeding, has symptom nausea and has symptom vomiting.

MalaCards based summary : Intestinal Tuberculosis, also known as tuberculosis of intestines, is related to intestinal obstruction and mycobacterium tuberculosis 1, and has symptoms including vomiting, abdominal pain and nausea. An important gene associated with Intestinal Tuberculosis is NT5E (5'-Nucleotidase Ecto), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Folate Metabolism. Affiliated tissues include intestine, colon and small intestine.

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Related Diseases for Intestinal Tuberculosis

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Diseases related to Intestinal Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 526)
# Related Disease Score Top Affiliating Genes
1 intestinal obstruction 30.7 NOD2 CRP ALB
2 mycobacterium tuberculosis 1 30.6 TNF NOD2 IFNG CD4
3 pulmonary tuberculosis 30.4 TNF IFNG ALB
4 tuberculous peritonitis 30.4 IFNG CRP ALB
5 peritonitis 30.3 TNF CRP ALB
6 crohn's colitis 30.1 TNF NOD2 IFNG
7 anal fistula 29.9 TNF CRP
8 enterocolitis 29.8 TNF NOD2 CRP
9 appendicitis 29.7 TNF IFNG CRP ALB
10 crohn's disease 29.7 TNF NOD2 IL22 IFNG CRP CD4
11 candidiasis 29.5 TNF IL22 IFNG
12 ulcerative colitis 29.5 TNF NOD2 IL22 IFNG CRP
13 diarrhea 29.5 TNF NOD2 IFNG ALB
14 purpura 29.5 TNF IFNG CRP
15 toxic shock syndrome 29.4 TNF IFNG CRP
16 arthropathy 29.4 TNF IFNG CRP
17 uveitis 29.4 TNF NOD2 IFNG
18 ileocolitis 29.4 TNF NOD2
19 intestinal perforation 29.4 TNF NOD2 CRP CD4 ALB
20 diverticulitis 29.3 TNF CRP ALB
21 typhoid fever 29.3 TNF IFNG CRP ALB
22 amebiasis 29.3 TNF CD4 ALB
23 uremia 29.3 TNF CRP ALB
24 schistosomiasis 29.2 TNF IFNG ALB
25 miliary tuberculosis 29.2 TNF IFNG CRP CD4 ALB
26 pleural tuberculosis 29.2 TNF IFNG CD4
27 histoplasmosis 29.2 TNF IFNG CD4
28 inflammatory bowel disease 29.2 TNF NT5E NOD2 IL22 IFNG CRP
29 sclerosing cholangitis 29.2 TNF NOD2 ALB
30 erythema nodosum 29.2 TNF NOD2 IFNG CRP
31 abdominal tuberculosis 29.2 TNF MIR4659A IFNG CRP CD4 ALB
32 stomatitis 29.2 TNF IFNG CD4
33 otitis media 29.1 TNF IFNG CRP ALB
34 colitis 29.1 TNF NOD2 IL22 IFNG CD4
35 cholangitis 29.0 TNF NOD2 CRP ALB
36 arthritis 29.0 TNF NOD2 IFNG CRP ALB
37 iritis 28.9 TNF NOD2 CRP CD4
38 rheumatoid arthritis 28.9 TNF IL22RA1 IL22 IFNG CRP CD4
39 lymphadenitis 28.9 TNF NOD2 IFNG CRP CD4
40 actinomycosis 28.8 TNF CRP CD4 ALB
41 lymph node tuberculosis 28.8 TNF LTA4H IFNG CRP CD4
42 respiratory failure 28.7 TNF CRP CD4 ALB
43 disease by infectious agent 28.7 TNF NOD2 IFNG CRP CD4 ALB
44 sarcoidosis 1 28.7 TNF NOD2 IFNG CRP CD4
45 acquired immunodeficiency syndrome 28.6 TNF IFNG CRP CD4 ALB
46 cholangitis, primary sclerosing 28.5 TNF NOD2 CRP CD4 ALB
47 celiac disease 1 28.2 TNF NOD2 IFNG CRP CD4 ALB
48 behcet syndrome 28.0 TNF NOD2 IL22 IFNG CRP CD4
49 gastrointestinal tuberculosis 28.0 TNF NOD2 MIR4659A IFNG GP2 CUTA
50 petrositis 10.3 IFNG CRP

Graphical network of the top 20 diseases related to Intestinal Tuberculosis:



Diseases related to Intestinal Tuberculosis
Sources

Symptoms & Phenotypes for Intestinal Tuberculosis

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Symptoms:

12
  • • vomiting
  • • abdominal pain
  • • nausea
  • • gastrointestinal bleeding
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Drugs & Therapeutics for Intestinal Tuberculosis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intestinal Tuberculosis Diagnostics and the Differentiation From Crohn's Disease in Populations of High vs. Low Tuberculosis Endemicity Unknown status NCT01503099
2 Development of a Prediction Model for Differential Diagnosis Between Intestinal Tuberculosis and Crohn's Disease Completed NCT01392365

Search NIH Clinical Center for Intestinal Tuberculosis

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Genetic Tests for Intestinal Tuberculosis

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Anatomical Context for Intestinal Tuberculosis

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The Foundational Model of Anatomy Ontology organs/tissues related to Intestinal Tuberculosis:

19
Intestine

MalaCards organs/tissues related to Intestinal Tuberculosis:

40
Colon, Small Intestine, Lymph Node, Appendix, Whole Blood, Kidney, Pancreas
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Publications for Intestinal Tuberculosis

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Articles related to Intestinal Tuberculosis:

(show top 50) (show all 934)
# Title Authors PMID Year
1
Distinguishing intestinal tuberculosis from Crohn's disease. 61
33581752 2021
2
Serial measurements of faecal calprotectin may discriminate intestinal tuberculosis and Crohn's disease in patients started on antitubercular therapy. 61
32796361 2021
3
Distinguishing intestinal tuberculosis from Crohn's disease - Authors' reply. 61
33581751 2021
4
Diagnostic accuracy of the Xpert MTB/RIF assay for abdominal tuberculosis: a systematic review and meta-analysis. 61
32845790 2021
5
Deep-learning system for real-time differentiation between Crohn's disease, intestinal Behçet's disease, and intestinal tuberculosis. 61
33554375 2021
6
Intestinal tuberculosis or Crohn's disease: Illusion or delusion or allusion. 61
33553652 2021
7
Systematic reporting of computed tomography enterography/enteroclysis as an aid to reduce diagnostic dilemma when differentiating between intestinal tuberculosis and Crohn's disease: A prospective study at a tertiary care hospital. 61
33553653 2021
8
Intestinal tuberculosis or Crohn's disease: a review of the diagnostic models designed to differentiate between these two gastrointestinal diseases. 61
32311862 2021
9
An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect. 61
33542828 2021
10
Case of Crohn's Disease Initially Misdiagnosed as Intestinal Tuberculosis Due to Active Pulmonary Tuberculosis. 61
33495429 2021
11
Atypical Presentation of Celiac Disease: Recurrent Acute Small Bowel Obstruction. 61
33488134 2021
12
Sigmoid Colon Tuberculosis Revealed by a Perforation and Peritonitis. 61
33520488 2020
13
Challenges in the diagnosis and management of inflammatory bowel disease in resource-limited settings in Asia. 61
33181087 2020
14
Antitubercular Therapy Given to Differentiate Crohn's Disease From Intestinal Tuberculosis Predisposes to Stricture Formation. 61
32369567 2020
15
Protein-losing enteropathy in a preschool patient with intestinal tuberculosis. 61
33308835 2020
16
Distinct Sonographic Features of Intestinal Tuberculosis. 61
33185297 2020
17
Quantitative Proteomic Analysis of the Expression of SARS-CoV-2 Receptors in the Gut of Patients with Chronic Enterocolitis. 61
32975064 2020
18
Meta-analysis of anti-Saccharomyces cerevisiae antibodies as diagnostic markers of Behçet's disease with gastrointestinal involvement. 61
33028542 2020
19
Cryptococcal meningitis in non-HIV patients in the State of Amazonas, Northern Brazil. 61
33025379 2020
20
Can natural language processing help differentiate inflammatory intestinal diseases in China? Models applying random forest and convolutional neural network approaches. 61
32993636 2020
21
Spontaneous Intestinal Perforation in Pregnancy from a Pre-Existing Postoperative Adhesion: A Case Report. 61
33051169 2020
22
Significance of granuloma and granulomatous lymphangitis in the differential diagnosis of Crohn's disease. 61
32621394 2020
23
Intestinal tuberculosis in a patient with end-stage renal disease on hemodialysis: A case report. 61
32769931 2020
24
Effect of Nonsteroidal Anti-inflammatory Agents on Small Intestinal Injuries as Evaluated by Capsule Endoscopy. 61
32748299 2020
25
Differentiating intestinal tuberculosis and Crohn disease: Quo Vadis. 61
32552311 2020
26
Apoptosis in peripheral blood lymphocytes in intestinal tuberculosis and Crohn's disease: Implications to diagnostic differentiation. 61
32803718 2020
27
Peritoneal and intestinal tuberculosis in a non-immunocompromised patient without pulmonary involvement. 61
32718843 2020
28
Intestinal tuberculosis versus Inflammatory Bowel Diseases: a never-ending challenge. 61
32656568 2020
29
Clinical diagnosis and endoscopic analysis of 10 cases of intestinal tuberculosis. 61
32664157 2020
30
Coinfection of Typhoid Fever With Tuberculosis: A Challenge to Surgical Management. 61
32670677 2020
31
FDG-PET-CT Enterography Helps Determine Clinical Significance of Suspected Ileocecal Thickening: A Prospective Study. 61
32488818 2020
32
Prospective validation of CD4+CD25+FOXP3+ T-regulatory cells as an immunological marker to differentiate intestinal tuberculosis from Crohn's disease. 61
32375209 2020
33
Not All Terminal Ileitis Is Crohn's Disease: Intestinal Tuberculosis Causing Small Bowel Obstruction. 61
32360806 2020
34
Comparison of small bowel findings using capsule endoscopy between Crohn's disease and intestinal tuberculosis in Korea. 61
31847061 2020
35
Misdiagnosis of multiple synchronous small bowel adenocarcinomas as intestinal tuberculosis: a case report. 61
32299377 2020
36
Chronic vomiting in children: A prospective study reveals rumination syndrome is an important etiology that is underdiagnosed and untreated. 61
32436177 2020
37
Development of Disseminated Tuberculosis with Intestinal Involvement due to Adalimumab Administration Despite Latent Tuberculosis Treatment. 61
31761884 2020
38
How can gastro-intestinal tuberculosis diagnosis be improved? A prospective cohort study. 61
32228479 2020
39
Clinicopathological profile of gastrointestinal tuberculosis: a multinational ID-IRI study. 61
31758440 2020
40
Disseminated tuberculosis presenting as massive lower gastrointestinal bleeding. 61
32318501 2020
41
Esophageal tuberculosis complicated with intestinal tuberculosis: A case report. 61
32110678 2020
42
Strangulated Internal Hernia through Appendicular Tourniquet/Ring: Unusual Cause of Intestinal Obstruction. 61
32054825 2020
43
Intestinal ulcers as an initial finding in EBV-associated lymphoproliferative disorder: A case report. 61
32011464 2020
44
[Natural Killer/T cell primary extranasal ileum lymphoma]. 61
32520180 2020
45
Emerging source of infection - Mycobacterium tuberculosis in rescue dogs: a case report. 61
33294771 2020
46
Defining 'Satisfactory Response' to Therapy in Abdominal Tuberculosis: A Work in Progress. 61
30345933 2020
47
Severe gastrintestinal bleeding as an unusual presentation of pediatric tuberculosis: a situation for injectable antituberculous drugs use? 61
33146307 2020
48
Intestinal tuberculosis: Case series of three patients. 61
32257783 2020
49
Levels of TB-IGRA may help to differentiate between intestinal tuberculosis and Crohn's disease in patients with positive results. 61
32523624 2020
50
The epidemiology of extrapulmonary tuberculosis in China: A large-scale multi-center observational study. 61
32822367 2020
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Variations for Intestinal Tuberculosis

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Expression for Intestinal Tuberculosis

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Search GEO for disease gene expression data for Intestinal Tuberculosis.
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Pathways for Intestinal Tuberculosis

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Pathways related to Intestinal Tuberculosis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 65
Show member pathways
 13.04 TNF NOD2 IL22RA1 IL22 IFNG CD4
2
Folate Metabolism 1
Show member pathways
 11.96 TNF IFNG CRP ALB
3
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.72 TNF IFNG CD4
4
Th17 cell differentiation 36
Show member pathways
 11.64 TNF NOD2 IL22RA1 IL22 IFNG CD4
5
Th17 Differentiation Pathway 64
Show member pathways
 11.57 IL22 IFNG CD4
6
Th1 Differentiation Pathway 64
Show member pathways
 11.46 TNF IFNG CD4
7
Dendritic Cells Developmental Lineage Pathway 64
11.41 TNF IFNG CD4
8
Innate Lymphoid Cell Differentiation Pathways 64
11.16 TNF IL22 IFNG CD4
9
Development and heterogeneity of the ILC family 1
10.94 TNF IL22 IFNG
10
Cytokines and Inflammatory Response 1
10.79 TNF IFNG CD4
11
Overview of nanoparticle effects 1
10.77 TNF CRP
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GO Terms for Intestinal Tuberculosis

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Cellular components related to Intestinal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 TNF NT5E NOD2 GP2 CD4

Biological processes related to Intestinal Tuberculosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.76 TNF IL22RA1 IL22 CD4
2 defense response to Gram-positive bacterium GO:0050830 9.67 TNF NOD2 CRP
3 positive regulation of interleukin-6 production GO:0032755 9.61 TNF NOD2 IFNG
4 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.54 NOD2 IFNG
5 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.52 TNF IFNG
6 astrocyte activation GO:0048143 9.51 TNF IFNG
7 positive regulation of interleukin-1 beta production GO:0032731 9.5 IFNG NOD2 TNF
8 negative regulation of amyloid-beta clearance GO:1900222 9.48 TNF IFNG
9 positive regulation of phagocytosis GO:0050766 9.43 IFNG NOD2 TNF
10 negative regulation of lipid storage GO:0010888 9.4 TNF CRP
11 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.37 NOD2 TNF
12 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IFNG TNF
13 positive regulation of nitrogen compound metabolic process GO:0051173 8.96 IFNG TNF
14 positive regulation of vitamin D biosynthetic process GO:0060557 8.62 IFNG TNF
Sources

Sources for Intestinal Tuberculosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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