MCID: INT046
MIFTS: 41

Intestinal Tuberculosis

Categories: Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Intestinal Tuberculosis

MalaCards integrated aliases for Intestinal Tuberculosis:

Name: Intestinal Tuberculosis 12 15
Tuberculosis of Intestines 71
Tuberculosis of Intestine 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13282
ICD9CM 34 014.8
UMLS 71 C0152724 C0275911

Summaries for Intestinal Tuberculosis

Disease Ontology : 12 A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located in intestine. The infection has symptom abdominal pain, has symptom gastrointestinal bleeding, has symptom nausea and has symptom vomiting.

MalaCards based summary : Intestinal Tuberculosis, also known as tuberculosis of intestines, is related to ileus and mycobacterium tuberculosis 1, and has symptoms including vomiting, abdominal pain and nausea. An important gene associated with Intestinal Tuberculosis is NT5E (5'-Nucleotidase Ecto), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Folate Metabolism. The drugs Clarithromycin and Antitubercular Agents have been mentioned in the context of this disorder. Affiliated tissues include intestine, colon and small intestine, and related phenotype is immune system.

Related Diseases for Intestinal Tuberculosis

Diseases related to Intestinal Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 488)
# Related Disease Score Top Affiliating Genes
1 ileus 30.4 TNF IFNG CRP
2 mycobacterium tuberculosis 1 30.4 TNF NOD2 IFNG CRP CD4
3 crohn's colitis 30.2 TNF NOD2 IFNG
4 pulmonary tuberculosis 30.0 TNF IFNG CRP ALB
5 tuberculous peritonitis 30.0 IFNG CRP ALB
6 ileitis 29.8 TNF NOD2 CD4
7 intestinal obstruction 29.7 TNF NOD2 CRP ALB
8 peritonitis 29.7 TNF IFNG CRP ALB
9 candidiasis 29.7 TNF IL22 IFNG
10 toxic shock syndrome 29.6 TNF IFNG CRP
11 purpura 29.6 TNF IFNG CRP
12 arthropathy 29.6 TNF IFNG CRP
13 uveitis 29.5 TNF NOD2 IFNG
14 proctitis 29.5 TNF NOD2 CRP
15 pyoderma 29.5 TNF NOD2 CRP
16 colitis 29.5 TNF NOD2 IL22 IFNG
17 diarrhea 29.5 TNF NOD2 IFNG ALB
18 pleural tuberculosis 29.4 TNF IFNG CD4
19 histoplasmosis 29.4 TNF IFNG CD4
20 ulcerative colitis 29.4 TNF NOD2 IL22 IFNG CRP
21 appendicitis 29.3 TNF IFNG CRP ALB
22 stomatitis 29.3 TNF IFNG CD4
23 ileocolitis 29.2 TNF NOD2
24 lymph node tuberculosis 29.1 TNF LTA4H IFNG CD4
25 actinomycosis 29.1 CRP CD4 ALB
26 diverticulitis 29.1 TNF CRP ALB
27 amebiasis 29.0 TNF CD4 ALB
28 crohn's disease 29.0 TNF NOD2 IL22 IFNG CRP CD4
29 iritis 29.0 TNF NOD2 CRP CD4
30 schistosomiasis 29.0 TNF IFNG ALB
31 intestinal perforation 29.0 TNF NOD2 CRP CD4 ALB
32 sclerosing cholangitis 28.9 TNF NOD2 ALB
33 lymphadenitis 28.9 TNF NOD2 IFNG CRP CD4
34 rheumatoid arthritis 28.9 TNF IL22RA1 IL22 IFNG CRP CD4
35 miliary tuberculosis 28.8 TNF IFNG CRP CD4 ALB
36 extrapulmonary tuberculosis 28.8 TNF IFNG CRP CD4 ALB
37 intestinal disease 28.8 TNF NOD2 CRP CD4 ALB
38 typhoid fever 28.7 TNF IFNG CRP ALB
39 otitis media 28.7 TNF IFNG CRP ALB
40 pancytopenia 28.7 IFNG CRP CD4 ALB
41 inflammatory bowel disease 28.7 TNF NT5E NOD2 IL22 IFNG CRP
42 sarcoidosis 1 28.6 TNF NOD2 IFNG CRP CD4
43 cholangitis 28.6 TNF NOD2 CRP ALB
44 respiratory failure 28.4 TNF CRP CD4 ALB
45 cholangitis, primary sclerosing 28.4 TNF NOD2 CD4 ALB
46 arthritis 28.3 TNF NOD2 IFNG CRP ALB
47 abdominal tuberculosis 28.2 TNF OR2H2 MIR4659A IFNG CRP CD4
48 acquired immunodeficiency syndrome 28.2 TNF IFNG CRP CD4 ALB
49 behcet syndrome 27.7 TNF NOD2 IFNG CRP CD4 ALB
50 celiac disease 1 27.7 TNF NOD2 IFNG CRP CD4 ALB

Graphical network of the top 20 diseases related to Intestinal Tuberculosis:



Diseases related to Intestinal Tuberculosis

Symptoms & Phenotypes for Intestinal Tuberculosis

Symptoms:

12
  • vomiting
  • abdominal pain
  • nausea
  • gastrointestinal bleeding

MGI Mouse Phenotypes related to Intestinal Tuberculosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 ALB CD4 CRP IFNG IL22 IL22RA1

Drugs & Therapeutics for Intestinal Tuberculosis

Drugs for Intestinal Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clarithromycin Approved Phase 3 81103-11-9 84029
2 Antitubercular Agents Phase 3
3 Cytochrome P-450 Enzyme Inhibitors Phase 3
4 Anti-Infective Agents Phase 3
5 Anti-Bacterial Agents Phase 3
6 Cytochrome P-450 CYP3A Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multi-centric Study on Treatment of Abdominal Tuberculosis (Intestinal or Peritoneal): A Randomized Controlled Trial to Compare the 6 Months of Cat I Treatment With 9 Months of Cat I Treatment (Extension for 3 Months) in Abdominal Tuberculosis Under the Revised National Tuberculosis Control Program Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
2 Randomised Controlled Trial of Clarithromycin in Active Crohn's Disease Completed NCT00269386 Phase 3 Clarithromycin;Placebo
3 Intestinal Tuberculosis Diagnostics and the Differentiation From Crohn's Disease in Populations of High vs. Low Tuberculosis Endemicity Unknown status NCT01503099
4 Development of a Prediction Model for Differential Diagnosis Between Intestinal Tuberculosis and Crohn's Disease Completed NCT01392365

Search NIH Clinical Center for Intestinal Tuberculosis

Genetic Tests for Intestinal Tuberculosis

Anatomical Context for Intestinal Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Intestinal Tuberculosis:

19
Intestine

MalaCards organs/tissues related to Intestinal Tuberculosis:

40
Colon, Small Intestine, Testes, Liver, T Cells, Lung, Lymph Node

Publications for Intestinal Tuberculosis

Articles related to Intestinal Tuberculosis:

(show top 50) (show all 875)
# Title Authors PMID Year
1
FDG-PET-CT Enterography Helps Determine Clinical Significance of Suspected Ileocecal Thickening: A Prospective Study. 61
32488818 2020
2
Differentiating intestinal tuberculosis and Crohn disease: Quo Vadis. 61
32552311 2020
3
Anti-tubercular therapy given to differentiate Crohn's disease from intestinal tuberculosis predisposes to stricture formation. 61
32369567 2020
4
Prospective validation of CD4+CD25+FOXP3+ T-regulatory cells as an immunological marker to differentiate intestinal tuberculosis from Crohn's disease. 61
32375209 2020
5
Intestinal tuberculosis or Crohn's disease: a review of the diagnostic models designed to differentiate between these two gastrointestinal diseases. 61
32311862 2020
6
Comparison of small bowel findings using capsule endoscopy between Crohn's disease and intestinal tuberculosis in Korea. 61
31847061 2020
7
Not All Terminal Ileitis Is Crohn's Disease: Intestinal Tuberculosis Causing Small Bowel Obstruction. 61
32360806 2020
8
Chronic vomiting in children: A prospective study reveals rumination syndrome is an important etiology that is underdiagnosed and untreated. 61
32436177 2020
9
Misdiagnosis of multiple synchronous small bowel adenocarcinomas as intestinal tuberculosis: a case report. 61
32299377 2020
10
How can gastro-intestinal tuberculosis diagnosis be improved? A prospective cohort study. 61
32228479 2020
11
Development of Disseminated Tuberculosis with Intestinal Involvement due to Adalimumab Administration Despite Latent Tuberculosis Treatment. 61
31761884 2020
12
Clinicopathological profile of gastrointestinal tuberculosis: a multinational ID-IRI study. 61
31758440 2020
13
Strangulated Internal Hernia through Appendicular Tourniquet/Ring: Unusual Cause of Intestinal Obstruction. 61
32054825 2020
14
Disseminated tuberculosis presenting as massive lower gastrointestinal bleeding. 61
32318501 2020
15
Esophageal tuberculosis complicated with intestinal tuberculosis: A case report. 61
32110678 2020
16
Intestinal tuberculosis: Case series of three patients. 61
32257783 2020
17
Intestinal ulcers as an initial finding in EBV-associated lymphoproliferative disorder: A case report. 61
32011464 2020
18
Defining 'Satisfactory Response' to Therapy in Abdominal Tuberculosis: A Work in Progress. 61
30345933 2020
19
[Natural Killer/T cell primary extranasal ileum lymphoma]. 61
32520180 2020
20
Levels of TB-IGRA may help to differentiate between intestinal tuberculosis and Crohn's disease in patients with positive results. 61
32523624 2020
21
Secondary Lymphedema After Intestinal Tuberculosis: A Case Report. 61
31918535 2019
22
Ileocecal thickening: Clinical approach to a common problem. 61
31832544 2019
23
Serum proteome profiles to differentiate Crohn disease from intestinal tuberculosis and primary intestinal lymphoma: A pilot study. 61
31852111 2019
24
GeneXpert in stool: Diagnostic yield in Intestinal Tuberculosis. 61
31788572 2019
25
Cooperation among Gastroenterological, Pathological and Microbiological Departments Is Needed to Avoid the Misdiagnosis of Intestinal Tuberculosis as Inflammatory Bowel Disease. 61
31327845 2019
26
The Author's Reply: Cooperation Among Gastroenterological, Pathological and Microbiological Departments Is Needed to Avoid the Misdiagnosis of Intestinal Tuberculosis as Inflammatory Bowel Disease. 61
31327850 2019
27
Peritoneal changes in intestinal tuberculosis. 61
31586578 2019
28
History of Inflammatory Bowel Diseases. 61
31739460 2019
29
Ulcerative intestinal tuberculosis case as a complication of treatment by infliximab for intestinal Behçet's disease: A case report. 61
31651888 2019
30
Imaging in discriminating intestinal tuberculosis and Crohn's disease: past, present and the future. 61
31559871 2019
31
Can ADC be used as a surrogate marker of response to therapy in intestinal tuberculosis? 61
31175381 2019
32
[Challenges in diagnostics for intestinal tuberculosis - Pitfalls of a forgotten infectious disease: case series and literature review]. 61
31525799 2019
33
Intestinal Tuberculosis and Crohn's Disease is Always a Diagnostic Challenge: A Case Report and Review of the Literature on the Importance of Fecal Mycobacterial Cultures and the Limitations of Latent Infection Testing. 61
31720158 2019
34
Analysis of Phenotypic Variables and Differentiation Between Untypical Crohn's Disease and Untypical Intestinal Tuberculosis. 61
30725295 2019
35
Ten Cases of Intestinal Tuberculosis Which Were Initially Misdiagnosed as Inflammatory Bowel Disease. 61
30918188 2019
36
Use of steroids for abdominal tuberculosis: a systematic review and meta-analysis. 61
30324229 2019
37
The potential role of CT enterography and gastrointestinal ultrasound in the evaluation of anti-tubercular therapy response of intestinal tuberculosis: a retrospective study. 61
31242849 2019
38
Interleukin-22 receptor 1 is expressed in multinucleated giant cells: A study on intestinal tuberculosis and Crohn's disease. 61
31171891 2019
39
Small bowel ulcers: when is it not inflammatory bowel disease ? 61
30865040 2019
40
Making a Positive Diagnosis of Intestinal Tuberculosis with the Aid of New Biologic and Histologic Features: How Far Have We Reached? 61
31111030 2019
41
Development and Validation of a Novel Diagnostic Nomogram to Differentiate Between Intestinal Tuberculosis and Crohn's Disease: A 6-year Prospective Multicenter Study. 61
30741735 2019
42
Intestinal Tuberculosis: A Rare Case of Massive Gastrointestinal Bleed in a Post-Renal Transplant Recipient. 61
30983756 2019
43
[Small bowel perforation caused by intestinal dissemination of pulmonary tuberculosis due to biological therapy]. 61
30869533 2019
44
The Polymorphism rs17525495 of LTA4H Is Associated with Susceptibility of Crohn's Disease instead of Intestinal Tuberculosis in a Chinese Han Population. 61
31093505 2019
45
All that fistulises is not Crohn's disease: Multiple entero-enteric fistulae in intestinal tuberculosis. 61
30919818 2019
46
[Intestinal tuberculosis revealed by acute bowel obstruction during paradoxical reaction to antituberculosis treatment in an immunocompetent patient: about a case and literature review]. 61
31303942 2019
47
Utility of tissue Xpert-Mtb/Rif for the diagnosis of intestinal tuberculosis in patients with ileocolonic ulcers. 61
31431826 2019
48
Concomitant lung and intestinal tuberculosis - case report. 61
31658350 2019
49
Differentiating Crohn's disease from intestinal tuberculosis. 61
30700939 2019
50
Intestinal tuberculosis simulating Crohn's disease: Differential diagnosis. 61
29548741 2019

Variations for Intestinal Tuberculosis

Expression for Intestinal Tuberculosis

Search GEO for disease gene expression data for Intestinal Tuberculosis.

Pathways for Intestinal Tuberculosis

GO Terms for Intestinal Tuberculosis

Cellular components related to Intestinal Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 TNF NT5E NOD2 GP2 CD4

Biological processes related to Intestinal Tuberculosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.71 TNF IL22RA1 IL22 CD4
2 astrocyte activation GO:0048143 9.49 TNF IFNG
3 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.48 TNF IFNG
4 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.46 NOD2 IFNG
5 positive regulation of chemokine biosynthetic process GO:0045080 9.43 TNF IFNG
6 negative regulation of amyloid-beta clearance GO:1900222 9.37 TNF IFNG
7 negative regulation of lipid storage GO:0010888 9.32 TNF CRP
8 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.26 TNF IFNG
9 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 TNF IFNG
10 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 TNF IFNG
11 positive regulation of nitrogen compound metabolic process GO:0051173 8.62 TNF IFNG

Sources for Intestinal Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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