MCID: INT046
MIFTS: 40

Intestinal Tuberculosis

Categories: Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Intestinal Tuberculosis

MalaCards integrated aliases for Intestinal Tuberculosis:

Name: Intestinal Tuberculosis 12 15
Tuberculosis of Intestines 71
Tuberculosis of Intestine 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13282
ICD9CM 34 014.8
UMLS 71 C0152724 C0275911

Summaries for Intestinal Tuberculosis

Disease Ontology : 12 A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located in intestine. The infection has symptom abdominal pain, has symptom gastrointestinal bleeding, has symptom nausea and has symptom vomiting.

MalaCards based summary : Intestinal Tuberculosis, also known as tuberculosis of intestines, is related to intestinal obstruction and intestinal perforation, and has symptoms including vomiting, abdominal pain and nausea. An important gene associated with Intestinal Tuberculosis is NT5E (5'-Nucleotidase Ecto), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Folate Metabolism. The drugs Clarithromycin and Antitubercular Agents have been mentioned in the context of this disorder. Affiliated tissues include intestine, colon and lung.

Related Diseases for Intestinal Tuberculosis

Diseases related to Intestinal Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 452)
# Related Disease Score Top Affiliating Genes
1 intestinal obstruction 30.7 NOD2 CRP ALB
2 intestinal perforation 30.6 NOD2 CRP ALB
3 tuberculous peritonitis 30.3 IFNG CRP ALB
4 mycobacterium tuberculosis 1 30.0 TNF NOD2 IFNG CRP CD4
5 ileus 30.0 TNF IFNG CRP
6 pulmonary tuberculosis 30.0 TNF IFNG CRP ALB
7 crohn's colitis 29.9 TNF NOD2 IFNG
8 laryngeal tuberculosis 29.7 IFNG CD4
9 peritonitis 29.7 TNF IFNG CRP ALB
10 lymph node tuberculosis 29.6 LTA4H IFNG CD4
11 actinomycosis 29.5 CRP CD4 ALB
12 ileocolitis 29.3 TNF NOD2
13 appendicitis 29.3 TNF IFNG CRP ALB
14 candidiasis 29.3 TNF IL22 IFNG
15 pancytopenia 29.3 IFNG CRP CD4
16 uveitis 29.2 TNF NOD2 IFNG
17 pyoderma 29.2 TNF NOD2 CRP
18 toxic shock syndrome 29.2 TNF IFNG CRP
19 arthropathy 29.2 TNF IFNG CRP
20 colitis 29.1 TNF NOD2 IL22 IFNG
21 amebiasis 29.1 TNF CD4 ALB
22 diverticulitis 29.1 TNF CRP ALB
23 ulcerative colitis 29.1 TNF NOD2 IL22 IFNG CRP
24 crohn's disease 29.1 TNF NOD2 IL22 IFNG CRP CD4
25 sclerosing cholangitis 29.0 TNF NOD2 ALB
26 pleural tuberculosis 29.0 TNF IFNG CD4
27 schistosomiasis 29.0 TNF IFNG ALB
28 histoplasmosis 29.0 TNF IFNG CD4
29 stomatitis 28.9 TNF IFNG CD4
30 miliary tuberculosis 28.8 TNF IFNG CRP CD4 ALB
31 extrapulmonary tuberculosis 28.8 TNF IFNG CRP CD4 ALB
32 cholangitis 28.7 TNF NOD2 CRP ALB
33 typhoid fever 28.7 TNF IFNG CRP ALB
34 otitis media 28.7 TNF IFNG CRP ALB
35 iritis 28.7 TNF NOD2 CRP CD4
36 inflammatory bowel disease 28.7 TNF NT5E NOD2 IL22 IFNG CRP
37 cholangitis, primary sclerosing 28.5 TNF NOD2 CD4 ALB
38 lymphadenitis 28.5 TNF NOD2 IFNG CRP CD4
39 respiratory failure 28.5 TNF CRP CD4 ALB
40 rheumatoid arthritis 28.4 TNF IL22RA1 IL22 IFNG CRP CD4
41 arthritis 28.3 TNF NOD2 IFNG CRP ALB
42 sarcoidosis 1 28.3 TNF NOD2 IFNG CRP CD4
43 abdominal tuberculosis 28.2 TNF OR2H2 NOD2 IFNG CRP CD4
44 acquired immunodeficiency syndrome 28.1 TNF IFNG CRP CD4 ALB
45 behcet syndrome 27.8 TNF NOD2 IFNG CRP CD4 ALB
46 celiac disease 1 27.8 TNF NOD2 IFNG CRP CD4 ALB
47 gastrointestinal tuberculosis 27.2 TNF OR2H2 NOD2 IFNG CRP CD4
48 guttate psoriasis 10.4 NOD2 IFNG
49 skeletal tuberculosis 10.4 IFNG CRP
50 chronic duodenal ileus 10.3 CRP ALB

Graphical network of the top 20 diseases related to Intestinal Tuberculosis:



Diseases related to Intestinal Tuberculosis

Symptoms & Phenotypes for Intestinal Tuberculosis

Symptoms:

12
  • vomiting
  • abdominal pain
  • nausea
  • gastrointestinal bleeding

Drugs & Therapeutics for Intestinal Tuberculosis

Drugs for Intestinal Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clarithromycin Approved Phase 3 81103-11-9 84029
2 Antitubercular Agents Phase 3
3 Cytochrome P-450 CYP3A Inhibitors Phase 3
4 Cytochrome P-450 Enzyme Inhibitors Phase 3
5 Anti-Infective Agents Phase 3
6 Anti-Bacterial Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multi-centric Study on Treatment of Abdominal Tuberculosis (Intestinal or Peritoneal): A Randomized Controlled Trial to Compare the 6 Months of Cat I Treatment With 9 Months of Cat I Treatment (Extension for 3 Months) in Abdominal Tuberculosis Under the Revised National Tuberculosis Control Program Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
2 Randomised Controlled Trial of Clarithromycin in Active Crohn's Disease Completed NCT00269386 Phase 3 Clarithromycin;Placebo
3 Intestinal Tuberculosis Diagnostics and the Differentiation From Crohn's Disease in Populations of High vs. Low Tuberculosis Endemicity Unknown status NCT01503099
4 Development of a Prediction Model for Differential Diagnosis Between Intestinal Tuberculosis and Crohn's Disease Completed NCT01392365

Search NIH Clinical Center for Intestinal Tuberculosis

Genetic Tests for Intestinal Tuberculosis

Anatomical Context for Intestinal Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Intestinal Tuberculosis:

19
Intestine

MalaCards organs/tissues related to Intestinal Tuberculosis:

40
Colon, Lung, Small Intestine, T Cells, Lymph Node, Bone, Skin

Publications for Intestinal Tuberculosis

Articles related to Intestinal Tuberculosis:

(show top 50) (show all 860)
# Title Authors PMID Year
1
Intestinal ulcers as an initial finding in EBV-associated lymphoproliferative disorder: A case report. 61
32011464 2020
2
Serum proteome profiles to differentiate Crohn disease from intestinal tuberculosis and primary intestinal lymphoma: A pilot study. 61
31852111 2019
3
GeneXpert in stool: Diagnostic yield in Intestinal Tuberculosis. 61
31788572 2019
4
Cooperation among Gastroenterological, Pathological and Microbiological Departments Is Needed to Avoid the Misdiagnosis of Intestinal Tuberculosis as Inflammatory Bowel Disease. 61
31327845 2019
5
The Author's Reply: Cooperation Among Gastroenterological, Pathological and Microbiological Departments Is Needed to Avoid the Misdiagnosis of Intestinal Tuberculosis as Inflammatory Bowel Disease. 61
31327850 2019
6
Ileocecal thickening: Clinical approach to a common problem. 61
31832544 2019
7
Secondary Lymphedema After Intestinal Tuberculosis: A Case Report. 61
31918535 2019
8
Peritoneal changes in intestinal tuberculosis. 61
31586578 2019
9
History of Inflammatory Bowel Diseases. 61
31739460 2019
10
Comparison of small bowel findings using capsule endoscopy between Crohn's disease and intestinal tuberculosis in Korea. 61
31847061 2019
11
Development of Disseminated Tuberculosis with Intestinal Involvement due to Adalimumab Administration Despite Latent Tuberculosis Treatment. 61
31761884 2019
12
Clinicopathological profile of gastrointestinal tuberculosis: a multinational ID-IRI study. 61
31758440 2019
13
Imaging in discriminating intestinal tuberculosis and Crohn's disease: past, present and the future. 61
31559871 2019
14
Ulcerative intestinal tuberculosis case as a complication of treatment by infliximab for intestinal Behçet's disease: A case report. 61
31651888 2019
15
[Challenges in diagnostics for intestinal tuberculosis - Pitfalls of a forgotten infectious disease: case series and literature review]. 61
31525799 2019
16
Can ADC be used as a surrogate marker of response to therapy in intestinal tuberculosis? 61
31175381 2019
17
Intestinal Tuberculosis and Crohn's Disease is Always a Diagnostic Challenge: A Case Report and Review of the Literature on the Importance of Fecal Mycobacterial Cultures and the Limitations of Latent Infection Testing. 61
31720158 2019
18
Ten Cases of Intestinal Tuberculosis Which Were Initially Misdiagnosed as Inflammatory Bowel Disease. 61
30918188 2019
19
Analysis of Phenotypic Variables and Differentiation Between Untypical Crohn's Disease and Untypical Intestinal Tuberculosis. 61
30725295 2019
20
Use of steroids for abdominal tuberculosis: a systematic review and meta-analysis. 61
30324229 2019
21
The potential role of CT enterography and gastrointestinal ultrasound in the evaluation of anti-tubercular therapy response of intestinal tuberculosis: a retrospective study. 61
31242849 2019
22
Interleukin-22 receptor 1 is expressed in multinucleated giant cells: A study on intestinal tuberculosis and Crohn's disease. 61
31171891 2019
23
Small bowel ulcers: when is it not inflammatory bowel disease ? 61
30865040 2019
24
Making a Positive Diagnosis of Intestinal Tuberculosis with the Aid of New Biologic and Histologic Features: How Far Have We Reached? 61
31111030 2019
25
Development and Validation of a Novel Diagnostic Nomogram to Differentiate Between Intestinal Tuberculosis and Crohn's Disease: A 6-year Prospective Multicenter Study. 61
30741735 2019
26
[Small bowel perforation caused by intestinal dissemination of pulmonary tuberculosis due to biological therapy]. 61
30869533 2019
27
Intestinal Tuberculosis: A Rare Case of Massive Gastrointestinal Bleed in a Post-Renal Transplant Recipient. 61
30983756 2019
28
The Polymorphism rs17525495 of LTA4H Is Associated with Susceptibility of Crohn's Disease instead of Intestinal Tuberculosis in a Chinese Han Population. 61
31093505 2019
29
All that fistulises is not Crohn's disease: Multiple entero-enteric fistulae in intestinal tuberculosis. 61
30919818 2019
30
[Intestinal tuberculosis revealed by acute bowel obstruction during paradoxical reaction to antituberculosis treatment in an immunocompetent patient: about a case and literature review]. 61
31303942 2019
31
Utility of tissue Xpert-Mtb/Rif for the diagnosis of intestinal tuberculosis in patients with ileocolonic ulcers. 61
31431826 2019
32
Differentiating Crohn's disease from intestinal tuberculosis. 61
30700939 2019
33
Concomitant lung and intestinal tuberculosis - case report. 61
31658350 2019
34
Intestinal tuberculosis simulating Crohn's disease: Differential diagnosis. 61
29548741 2019
35
Intestinal Tuberculosis Masquerading as Crohn's Disease? A Case of Disseminated Tuberculosis after Anti-TNF Therapy for Suspected Crohn's Disease. 61
31929918 2019
36
Intestinal tuberculosis: clinico-pathological profile and the importance of a high degree of suspicion. 61
30338607 2019
37
Correction: Exploration of Serum Proteomic Profiling and Diagnostic Model That Differentiate Crohn's Disease and Intestinal Tuberculosis. 61
30730981 2019
38
Primary enterolithiasis with intestinal tuberculosis: rare presentation of a common disease. 61
30580291 2018
39
Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders. 61
30366790 2018
40
Tuberculous colon perforation mimicking acute appendicitis: A case report and review of the literature. 61
30455912 2018
41
Disease not genetic but infectious: multiple tuberculomas and fibrinous pericarditis as symptoms pathognomonic for tuberculosis of Frederic Chopin. 61
30047032 2018
42
Crohn's disease with positive Ziehl-Neelsen stain: Three case reports. 61
30297577 2018
43
CD73 expression in tissue granulomas in distinguishing intestinal tuberculosis from Crohn's disease in a South African cohort. 61
30295112 2018
44
Diagnostic Performance of a 5-Marker Predictive Model for Differential Diagnosis Between Intestinal Tuberculosis and Crohn's Disease. 61
29860270 2018
45
Disseminated tuberculosis caused by Mycobacterium bovis presenting as a tongue base mass. 61
30323101 2018
46
Defining 'satisfactory response' to therapy in abdominal tuberculosis : A work in progress. 61
30345933 2018
47
Diagnostic Accuracy of Peritoneal Fluid GeneXpert in the Diagnosis of Intestinal Tuberculosis, Keeping Histopathology as the Gold Standard. 61
30564530 2018
48
Intestinal tuberculosis and Crohn's disease: the importance and difficulty of a differential diagnosis. 61
30168341 2018
49
Chicken intestine: Intestinal tuberculosis. 61
30309155 2018
50
Goose neck: Intestinal tuberculosis. 61
30309187 2018

Variations for Intestinal Tuberculosis

Expression for Intestinal Tuberculosis

Search GEO for disease gene expression data for Intestinal Tuberculosis.

Pathways for Intestinal Tuberculosis

GO Terms for Intestinal Tuberculosis

Biological processes related to Intestinal Tuberculosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.62 TNF IL22RA1 IL22 CD4
2 positive regulation of amyloid-beta formation GO:1902004 9.49 TNF IFNG
3 astrocyte activation GO:0048143 9.48 TNF IFNG
4 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.46 TNF IFNG
5 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.43 NOD2 IFNG
6 positive regulation of chemokine biosynthetic process GO:0045080 9.4 TNF IFNG
7 negative regulation of amyloid-beta clearance GO:1900222 9.37 TNF IFNG
8 negative regulation of lipid storage GO:0010888 9.26 TNF CRP
9 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IFNG TNF
10 positive regulation of nitrogen compound metabolic process GO:0051173 8.96 IFNG TNF
11 positive regulation of vitamin D biosynthetic process GO:0060557 8.62 IFNG TNF

Sources for Intestinal Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....