MCID: INT052
MIFTS: 38

Intestinal Volvulus

Categories: Gastrointestinal diseases

Aliases & Classifications for Intestinal Volvulus

MalaCards integrated aliases for Intestinal Volvulus:

Name: Intestinal Volvulus 12 44 15 73
Volvulus 12 29 55
Twist of Intestine, Bowel, or Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8445
ICD10 33 K56.2
ICD9CM 35 560.2
MeSH 44 D045822
NCIt 50 C98963
UMLS 73 C0042961

Summaries for Intestinal Volvulus

MalaCards based summary : Intestinal Volvulus, also known as volvulus, is related to duodenojejunal atresia with volvulus, absent dorsal mesentery, and absent superior mesenteric artery and onchocerciasis. An important gene associated with Intestinal Volvulus is TWIST1 (Twist Family BHLH Transcription Factor 1), and among its related pathways/superpathways is Antiarrhythmic Pathway, Pharmacodynamics. The drugs Ivermectin and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and liver, and related phenotypes are cardiovascular system and muscle

Wikipedia : 76 A volvulus is when a loop of intestine twists around itself and the mesentery that supports it,... more...

Related Diseases for Intestinal Volvulus

Diseases related to Intestinal Volvulus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 duodenojejunal atresia with volvulus, absent dorsal mesentery, and absent superior mesenteric artery 11.9
2 onchocerciasis 11.9
3 gastric volvulus, intrathoracic 11.9
4 volvulus of midgut 11.9
5 nodding syndrome 11.2
6 duodenal atresia 11.0
7 short bowel syndrome 11.0
8 norwegian scabies 10.0 KCNE1 TWIST1
9 chronic inflammation of lacrimal passage 9.9 KCNJ11 SRCIN1
10 cystic fibrosis 9.8
11 intestinal atresia 9.8
12 peritonitis 9.8
13 diaphragmatic hernia, congenital 9.7
14 intussusception 9.7
15 pelvic organ prolapse 9.7
16 anus, imperforate 9.7
17 jejunal atresia 9.7
18 familial mediterranean fever 9.7
19 gastrointestinal stromal tumor 9.7
20 porphyria, acute hepatic 9.7
21 meconium ileus 9.7
22 hepatitis 9.7
23 inguinal hernia 9.7
24 steatorrhea 9.7
25 brucellosis 9.7
26 cornelia de lange syndrome 9.7
27 leiomyoma 9.7
28 intestinal obstruction 9.7
29 lipoblastoma 9.7
30 alstrom syndrome 9.3 KCNJ11 NODAL

Comorbidity relations with Intestinal Volvulus via Phenotypic Disease Network (PDN): (show all 14)


Active Peptic Ulcer Disease Acute Cystitis
Acute Vascular Insufficiency of Intestine Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Intestinal Obstruction Paralytic Ileus
Parkinson Disease, Late-Onset Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder

Graphical network of the top 20 diseases related to Intestinal Volvulus:



Diseases related to Intestinal Volvulus

Symptoms & Phenotypes for Intestinal Volvulus

MGI Mouse Phenotypes related to Intestinal Volvulus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 CALR CLMP DAAM2 KCNJ11 NODAL SRCIN1
2 muscle MP:0005369 9.02 CALR DAAM2 KCNJ11 NODAL TWIST1

Drugs & Therapeutics for Intestinal Volvulus

Drugs for Intestinal Volvulus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 3,Phase 2 70288-86-7 6474909
2
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
3 Milbemycin Phase 3,Phase 2
4 Anthelmintics Phase 3,Phase 2
5 Vitamins Phase 3,Not Applicable
6 Anti-Infective Agents Phase 3,Phase 2
7 Antiparasitic Agents Phase 3,Phase 2
8 Antiprotozoal Agents Phase 3,Phase 2
9 Antimitotic Agents Phase 3
10
Rifampicin Approved Phase 2 13292-46-1 5458213 5381226
11
Azithromycin Approved Phase 2 83905-01-5 55185 447043
12
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
13 Cytochrome P-450 CYP3A Inducers Phase 2
14 Nucleic Acid Synthesis Inhibitors Phase 2
15 Anti-Bacterial Agents Phase 2
16 Antibiotics, Antitubercular Phase 2
17 Antitubercular Agents Phase 2
18 Antimalarials Phase 2
19
Suramin Approved, Investigational 145-63-1 5361
20
Diethylcarbamazine Approved, Investigational, Vet_approved 90-89-1 3052
21 Micronutrients Not Applicable
22 Trace Elements Not Applicable
23 Pharmaceutical Solutions Not Applicable
24 lysine Nutraceutical Not Applicable
25 Cola Nutraceutical Not Applicable

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection Completed NCT00790998 Phase 3 Moxidectin;Ivermectin
2 IVM Alone vs ALB + IVM Against Onchocerciasis Completed NCT03238131 Phase 3 Ivermectin;Albendazole
3 Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana Active, not recruiting NCT02078024 Phase 3 IVM plus ALB;IVM
4 Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed NCT00300768 Phase 2 2 mg moxidectin;ivermectin 150 mcg/kg;4 mg moxidectin;8 mg moxidectin
5 Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness Completed NCT00127504 Phase 2 Rifampin;Azithromycin
6 Doxycycline for the Treatment of Nodding Syndrome Recruiting NCT02850913 Phase 2 Doxycycline
7 Pediatric Pharmacokinetics And Safety Study Of Moxidectin Withdrawn NCT01035619 Phase 2 moxidectin
8 A RETROspective Data Collection of comPRESSion Anastomosis Using the ColonRing Unknown status NCT01880918
9 Prenatal Diagnosis of Antenatal Midgut Volvulus: Specific Ultrasound Features Completed NCT03362450
10 Best Management of Sigmoid Volvulus: A Prospective Randomized Trial Completed NCT01682395 Not Applicable
11 Prenatal Ultrasound Screening of Intestinal Malrotation With a Higher Risk of Volvulus Completed NCT03356314
12 Heterotaxy Syndrome and Intestinal Rotation Abnormalities - A Prospective Study Completed NCT01591928
13 Determination of Lysine Requirement in the Parenterally Fed Neonate Completed NCT00779753 Not Applicable
14 Data Collection of Patients Treated With the ColonRing™ for the Creation of Circular Compression Anastomosis Completed NCT01301417
15 Prevalence of LF Infection in Districts Not Included in LF Control Activities Recruiting NCT03131401
16 Host Response to Infection and Treatment in Filarial Diseases Recruiting NCT00001230
17 Regional Blood Saturation Levels in Gastroschisis Active, not recruiting NCT03533439
18 Ocular Changes After Ivermectin - (DOLF IVM/Oncho) Not yet recruiting NCT03517462 Not Applicable Ivermectin 3Mg Tab

Search NIH Clinical Center for Intestinal Volvulus

Cochrane evidence based reviews: intestinal volvulus

Genetic Tests for Intestinal Volvulus

Genetic tests related to Intestinal Volvulus:

# Genetic test Affiliating Genes
1 Volvulus 29

Anatomical Context for Intestinal Volvulus

MalaCards organs/tissues related to Intestinal Volvulus:

41
Small Intestine, Colon, Liver

Publications for Intestinal Volvulus

Articles related to Intestinal Volvulus:

(show top 50) (show all 100)
# Title Authors Year
1
Role of the ultrasonographic 'whirlpool sign' in intestinal volvulus: a systematic review and meta-analysis. ( 29740967 )
2018
2
Is isomerism a risk factor for intestinal volvulus? ( 29605269 )
2018
3
Primary small intestinal volvulus after laparoscopic rectopexy for rectal prolapse. ( 29388327 )
2018
4
Antenatal diagnosis and management of foetal intestinal volvulus. ( 28473678 )
2017
5
Swirl Sign - Intestinal Volvulus after Roux-en-Y Gastric Bypass. ( 28099828 )
2017
6
Mesenteric lipoblastoma presenting as a small intestinal volvulus in an infant: A case report and literature review. ( 28034384 )
2017
7
Ladd procedure for malrotation with total intestinal volvulus. ( 28522281 )
2017
8
Prenatal intestinal volvulus: look for cystic fibrosis. ( 28003230 )
2016
9
Intestinal Volvulus: A Life-Threatening Disease. ( 27134960 )
2016
10
Intestinal volvulus related to malrotation in adults. ( 26732263 )
2016
11
Comparison of Surgically Treated Large Versus Small Intestinal Volvulus (2009-2014). ( 27259023 )
2016
12
Rare small intestinal volvulus from entrapment in hepato-diaphragmatic adhesions in a 45-year-old lady. ( 28003317 )
2016
13
Intestinal volvulus after conservative management of incidental midgut malrotation discovered at laparoscopic appendectomy in a teenager. ( 28240469 )
2016
14
The Whirl Sign and Small Intestinal Volvulus. ( 26976810 )
2016
15
Imperforate Anus with Jejunal Atresia Complicated by Intestinal Volvulus: A Case Report. ( 27896167 )
2016
16
A case of fetal intestinal volvulus without malrotation causing severe anemia. ( 25628516 )
2015
17
A case of child death caused by intestinal volvulus following magnetic toy ingestion. ( 25515117 )
2015
18
A neonate with intestinal volvulus without malrotation exhibiting early jaundice with a suspected fetal onset. ( 27186710 )
2015
19
Prenatal diagnosis of intestinal volvulus in a foetus with homozygous M470V cystic fibrosis gene polymorphism. ( 25383610 )
2014
20
Video of the month: whirlpool sign in intestinal volvulus. ( 24698858 )
2014
21
Prenatal diagnosis and management of an intestinal volvulus with meconium ileus and peritonitis. ( 24682585 )
2014
22
Small-intestinal volvulus after subtotal colectomy visualized during colonoscopy. ( 24830576 )
2014
23
Intestinal volvulus and its increased incidence in patients with Cornelia de Lange syndrome. ( 24295644 )
2013
24
Sonographic diagnosis of fetal intestinal volvulus with ileal atresia: a case report. ( 22585388 )
2013
25
Recurrent intestinal volvulus in midgut malrotation causing acute bowel obstruction: A case report. ( 23556060 )
2013
26
Intestinal volvulus in cetaceans. ( 23150643 )
2013
27
Perinatal survival of a fetus with intestinal volvulus and intussusception: a case report and review of the literature. ( 24147247 )
2013
28
Gastrointestinal stromal tumor of Meckel's diverticulum: a rare cause of intestinal volvulus. ( 22965517 )
2012
29
Intestinal volvulus: aetiology, morbidity and mortality in Tunisian children. ( 22005353 )
2011
30
Small intestinal volvulus in a free-ranging female dugong (Dugong dugon). ( 21696379 )
2011
31
Neonatal intestinal volvulus and preduodenal portal vein associated with situs ambiguus: report of a case. ( 21533951 )
2011
32
Images in clinical medicine. Small-intestinal volvulus. ( 21793747 )
2011
33
Late intestinal obstruction due to an intestinal volvulus in a pregnant patient with a previous Roux-en-Y gastric bypass. ( 19319613 )
2010
34
Intestinal volvulus with coagulative hepatic necrosis in a chicken. ( 19959885 )
2010
35
Successful treatment of small intestinal volvulus in two cats. ( 20974405 )
2010
36
Small intestinal volvulus caused by loose surgical staples. ( 19735833 )
2009
37
[Dolichomegacolon of the Andes and intestinal volvulus due to altitude]. ( 18958141 )
2008
38
Intestinal volvulus following laparoscopic surgery: a literature review and case report. ( 18503375 )
2008
39
Small-intestinal volvulus around the superior mesenteric artery as an extremely rare positioning-associated complication after percutaneous liver biopsy. ( 18516544 )
2008
40
Neonatal intestinal volvulus due to a persistent right vitelline artery. ( 17024295 )
2007
41
Intestinal volvulus and perforation caused by multiple magnet ingestion: report of a case. ( 17186347 )
2007
42
An unusual complication of familial Mediterranean fever: intestinal volvulus and necrosis. ( 16941262 )
2006
43
Small intestinal volvulus in a captive Steller sea lion (Eumetopias jubatus). ( 16816158 )
2006
44
An intestinal volvulus caused by multiple magnet ingestion: an unexpected risk in children. ( 16150334 )
2005
45
Small intestinal volvulus in 115 horses: 1988-2000. ( 15230835 )
2004
46
Factors associated with mortality and morbidity in small intestinal volvulus in horses. ( 15230836 )
2004
47
'Whirlpool' sign in the prenatal diagnosis of intestinal volvulus. ( 12230462 )
2002
48
Small intestinal volvulus following laparotomy for endometrial clear cell carcinoma in a woman with a past history of total gastrectomy and Roux-en-Y anastomosis for gastric carcinoma. ( 12468333 )
2002
49
Rare complication of intestinal volvulus with perforation of the small bowel secondary to the peritoneal end of the ventriculoperitoneal shunt (VPS). ( 11315306 )
2001
50
Small intestinal volvulus in Southern Ethiopia. ( 12002073 )
2001

Variations for Intestinal Volvulus

Expression for Intestinal Volvulus

Search GEO for disease gene expression data for Intestinal Volvulus.

Pathways for Intestinal Volvulus

Pathways related to Intestinal Volvulus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.37 KCNE1 KCNJ11

GO Terms for Intestinal Volvulus

Biological processes related to Intestinal Volvulus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 determination of left/right symmetry GO:0007368 9.37 DAAM2 NODAL
2 negative regulation of cell differentiation GO:0045596 9.32 NODAL TWIST1
3 positive regulation of epithelial cell proliferation GO:0050679 9.26 NODAL TWIST1
4 response to testosterone GO:0033574 9.16 CALR KCNJ11
5 embryonic cranial skeleton morphogenesis GO:0048701 8.96 NODAL TWIST1
6 negative regulation of trophoblast cell migration GO:1901164 8.62 CALR NODAL

Molecular functions related to Intestinal Volvulus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated potassium channel activity GO:0005249 8.62 KCNE1 KCNJ11

Sources for Intestinal Volvulus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
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45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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