MCID: INT052
MIFTS: 43

Intestinal Volvulus

Categories: Gastrointestinal diseases

Aliases & Classifications for Intestinal Volvulus

MalaCards integrated aliases for Intestinal Volvulus:

Name: Intestinal Volvulus 12 45 15 17 74
Volvulus 12 30 56 15
Twist of Intestine, Bowel, or Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8445
ICD9CM 36 560.2
MeSH 45 D045822
NCIt 51 C98963
SNOMED-CT 69 90738007 9707006
ICD10 34 K56.2
UMLS 74 C0042961

Summaries for Intestinal Volvulus

MalaCards based summary : Intestinal Volvulus, also known as volvulus, is related to onchocerciasis and hernia, hiatus. An important gene associated with Intestinal Volvulus is TWIST1 (Twist Family BHLH Transcription Factor 1), and among its related pathways/superpathways is tRNA processing. The drugs Ivermectin and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and skin.

Wikipedia : 77 A volvulus is when a loop of intestine twists around itself and the mesentery that supports it,... more...

Related Diseases for Intestinal Volvulus

Diseases related to Intestinal Volvulus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)
# Related Disease Score Top Affiliating Genes
1 onchocerciasis 32.7 CALR IL5
2 hernia, hiatus 30.4 LAGE3 TPRKB WDR73
3 filarial elephantiasis 29.6 IL5 SRCIN1
4 volvulus of midgut 12.2
5 duodenojejunal atresia with volvulus, absent dorsal mesentery, and absent superior mesenteric artery 12.1
6 gastric volvulus, intrathoracic 12.1
7 nodding syndrome 11.4
8 abdominal cystic lymphangioma 11.4
9 duodenal atresia 11.2
10 short bowel syndrome 11.2
11 gastric dilatation 10.7
12 wandering spleen 10.3
13 megacolon 10.2
14 meckel diverticulum 10.2
15 senile ectropion 10.2 SRCIN1 TWIST1
16 duodenal obstruction 10.2
17 yemenite deaf-blind hypopigmentation syndrome 10.1
18 lymphangioma 10.1
19 situs inversus 10.1
20 chilaiditi syndrome 10.1
21 colitis 10.1
22 appendicitis 10.1
23 degos 'en cocarde' erythrokeratoderma 10.1
24 filariasis 10.0
25 pancreatitis 10.0
26 cardiac tamponade 10.0
27 epilepsy 10.0
28 cholecystitis 10.0
29 constipation 10.0
30 acanthocheilonemiasis 10.0
31 cystic fibrosis 10.0
32 intestinal atresia 10.0
33 crohn's disease 9.9
34 morbid obesity 9.9
35 ulcerative colitis 9.9
36 pyloric stenosis 9.9
37 schistosomiasis 9.9
38 colonic pseudo-obstruction 9.9
39 intestinal pseudo-obstruction 9.9
40 hypertelorism 9.9 TPRKB TWIST1
41 keratitis, hereditary 9.9
42 leiomyoma, uterine 9.9
43 marfan syndrome 9.9
44 tracheoesophageal fistula with or without esophageal atresia 9.9
45 ascites, chylous 9.9
46 diaphragmatic eventration 9.9
47 esophageal atresia 9.9
48 mansonelliasis 9.9
49 acute pancreatitis 9.9
50 lipomatosis 9.9

Comorbidity relations with Intestinal Volvulus via Phenotypic Disease Network (PDN): (show all 14)


Active Peptic Ulcer Disease Acute Cystitis
Acute Vascular Insufficiency of Intestine Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Intestinal Obstruction Paralytic Ileus
Parkinson Disease, Late-Onset Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder

Graphical network of the top 20 diseases related to Intestinal Volvulus:



Diseases related to Intestinal Volvulus

Symptoms & Phenotypes for Intestinal Volvulus

Drugs & Therapeutics for Intestinal Volvulus

Drugs for Intestinal Volvulus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 70288-86-7 6474909
2
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
3 Milbemycin Phase 3,Phase 2
4 Anthelmintics Phase 3,Phase 2
5 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
6 Antiparasitic Agents Phase 3,Phase 2,Not Applicable
7 Antiprotozoal Agents Phase 3,Phase 2
8 Antimitotic Agents Phase 3
9 Vitamins Phase 3,Not Applicable
10
Azithromycin Approved Phase 2 83905-01-5 55185 447043
11
Rifampicin Approved Phase 2 13292-46-1 5381226 5458213
12
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
13 Nucleic Acid Synthesis Inhibitors Phase 2
14 Cytochrome P-450 CYP3A Inducers Phase 2
15 Antibiotics, Antitubercular Phase 2
16 Antitubercular Agents Phase 2
17 Anti-Bacterial Agents Phase 2
18 Antimalarials Phase 2
19
Diethylcarbamazine Approved, Investigational, Vet_approved 90-89-1 3052
20
Suramin Investigational 145-63-1 5361
21 Cola Not Applicable
22 Trace Elements Not Applicable
23 Micronutrients Not Applicable
24 Pharmaceutical Solutions Not Applicable
25 lysine Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection Completed NCT00790998 Phase 3 Moxidectin;Ivermectin
2 IVM Alone vs ALB + IVM Against Onchocerciasis Completed NCT03238131 Phase 3 Ivermectin;Albendazole
3 Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana Active, not recruiting NCT02078024 Phase 3 IVM plus ALB;IVM
4 Safety and Efficacy of Annual or Biannual Doses of Moxidectin or Ivermectin for Onchocerciasis Not yet recruiting NCT03876262 Phase 3 Moxidectin;Ivermectin
5 Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed NCT00300768 Phase 2 2 mg moxidectin;ivermectin 150 mcg/kg;4 mg moxidectin;8 mg moxidectin
6 Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness Completed NCT00127504 Phase 2 Rifampin;Azithromycin
7 Doxycycline for the Treatment of Nodding Syndrome Recruiting NCT02850913 Phase 2 Doxycycline
8 Pediatric Pharmacokinetics And Safety Study Of Moxidectin Withdrawn NCT01035619 Phase 2 moxidectin
9 A RETROspective Data Collection of comPRESSion Anastomosis Using the ColonRing Unknown status NCT01880918
10 Prenatal Diagnosis of Antenatal Midgut Volvulus: Specific Ultrasound Features Completed NCT03362450
11 Best Management of Sigmoid Volvulus: A Prospective Randomized Trial Completed NCT01682395 Not Applicable
12 Prenatal Ultrasound Screening of Intestinal Malrotation With a Higher Risk of Volvulus Completed NCT03356314
13 Prevalence of LF Infection in Districts Not Included in LF Control Activities Completed NCT03131401
14 Heterotaxy Syndrome and Intestinal Rotation Abnormalities - A Prospective Study Completed NCT01591928
15 Determination of Lysine Requirement in the Parenterally Fed Neonate Completed NCT00779753 Not Applicable
16 Data Collection of Patients Treated With the ColonRing™ for the Creation of Circular Compression Anastomosis Completed NCT01301417
17 Clinical Features and Potential Etiology of Epilepsy and Nodding Syndrome in the Mahenge Area, Ulanga District Recruiting NCT03653975
18 Host Response to Infection and Treatment in Filarial Diseases Recruiting NCT00001230
19 Stapled Anastomosis Versus Hand-sewn for Neonate With Intestinal Atresia Recruiting NCT03754907 Not Applicable
20 Evaluation of the Risks and Benefits of Abdominal Massage Treatment in Neonatalogy in Premature Children Recruiting NCT03681782
21 Regional Blood Saturation Levels in Gastroschisis Active, not recruiting NCT03533439
22 Ocular Changes After Ivermectin - (DOLF IVM/Oncho) Enrolling by invitation NCT03517462 Not Applicable Ivermectin 3Mg Tab

Search NIH Clinical Center for Intestinal Volvulus

Cochrane evidence based reviews: intestinal volvulus

Genetic Tests for Intestinal Volvulus

Genetic tests related to Intestinal Volvulus:

# Genetic test Affiliating Genes
1 Volvulus 30

Anatomical Context for Intestinal Volvulus

MalaCards organs/tissues related to Intestinal Volvulus:

42
Colon, Small Intestine, Skin, Liver, Testes, Neutrophil, T Cells

Publications for Intestinal Volvulus

Articles related to Intestinal Volvulus:

(show top 50) (show all 2583)
# Title Authors Year
1
Rare occurrence of small bowel volvulus following laparoscopic appendicectomy for perforated appendicitis. ( 30697417 )
2019
2
Integrated seroprevalence-based assessment of Wuchereria bancrofti and Onchocerca volvulus in two lymphatic filariasis evaluation units of Mali with the SD Bioline Onchocerciasis/LF IgG4 Rapid Test. ( 30699120 )
2019
3
Transient distal renal tubular acidosis in a dog with gastric-dilatation-volvulus. ( 30705453 )
2019
4
Fetal Primary Small Bowel Volvulus Associated with Acute Gastric Dilatation Detected by Ultrasonography. ( 30728342 )
2019
5
Secondary pneumatosis cystoides intestinalis complicated by intestinal volvulus: A case report and literature review. ( 30661712 )
2019
6
Experimental study on prophylactic effects of vardenafil in ischemia-reperfusion model with intestinal volvulus injury in rats. ( 30885562 )
2019
7
Small Bowel Volvulus Caused by Small Intestinal B Cell Lymphoma. ( 30788713 )
2019
8
Primary midgut volvulus in a patient with Marfan syndrome. ( 30788104 )
2019
9
Transverse colon volvulus in a patient with sickle cell disease. ( 30852505 )
2019
10
Omega sign: Radiological appearance of sigmoid volvulus. ( 30628190 )
2019
11
Gastric volvulus: unraveling the diagnosis with MPRs. ( 30644001 )
2019
12
Development of a preliminary in vitro drug screening assay based on a newly established culturing system for pre-adult fifth-stage Onchocerca volvulus worms. ( 30653499 )
2019
13
Acute gastric volvulus with pneumatosis intestinalis and portal venous gas secondary to hiatus hernia induced gastric outlet obstruction. ( 30675980 )
2019
14
Patent infections with soil-transmitted helminths and Schistosoma mansoni are not associated with increased prevalence of antibodies to the Onchocerca volvulus peptide epitopes OvMP-1 and OvMP-23. ( 30691520 )
2019
15
Very rare case of synchronous volvulus of the sigmoid colon and caecum causing large-bowel obstruction. ( 30696645 )
2019
16
Ileal conduit volvulus: rare complication of urinary diversion. ( 30696652 )
2019
17
A Multi-institutional Case Series With Review of Point-of-Care Ultrasound to Diagnose Malrotation and Midgut Volvulus in the Pediatric Emergency Department. ( 30702647 )
2019
18
Target and whirl signs: volvulus of intussuscepted colon in an infant. ( 30710705 )
2019
19
Single-incision laparoscopic gastropexy for mesentero-axial gastric volvulus. ( 30715642 )
2019
20
Gastroscope guidewire volvulus tube decompression. ( 30719575 )
2019
21
Second-trimester presentation of midgut volvulus without intestinal malrotation. ( 30761657 )
2019
22
Atraumatic splenic rupture secondary to appendicular perforation by cecal volvulus. ( 30768070 )
2019
23
Progressive atrophy in a deformed liver as a contributor to sigmoid volvulus. ( 30796695 )
2019
24
An unusual case of perisplenic small bowel volvulus after laparoscopic Roux En Y gastric bypass. ( 30800275 )
2019
25
Long-term outcomes of ultrashort bowel syndrome due to malrotation with midgut volvulus managed at an interdisciplinary pediatric intestinal rehabilitation center. ( 30826119 )
2019
26
Gallbladder volvulus: A rare cause of acute gallbladder distension. ( 30873662 )
2019
27
Sigmoid volvulus: Comorbidity with sigmoid gangrene. ( 30881440 )
2019
28
Ventricular tachycardia in a patient with sigmoid volvulus on treatment with donepezil. ( 30896286 )
2019
29
Management and outcomes of gastric volvulus in children: a systematic review. ( 30900131 )
2019
30
Sigmoid volvulus: the first one thousand-case single center series in the world. ( 29079918 )
2019
31
Role of the ultrasonographic 'whirlpool sign' in intestinal volvulus: a systematic review and meta-analysis. ( 29740967 )
2018
32
Is isomerism a risk factor for intestinal volvulus? ( 29605269 )
2018
33
Primary small intestinal volvulus after laparoscopic rectopexy for rectal prolapse. ( 29388327 )
2018
34
Primary intestinal aspergillosis resulting in acute intestinal volvulus after autologous stem cell transplantation in a patient with relapsed non-Hodgkin lymphoma: report on a rare infectious complication and a review of the literature. ( 30238855 )
2018
35
Acute gastric volvulus presenting as a pseudo cardiac tamponade. ( 30209140 )
2018
36
The lethal twist - a story of unspoken pain: small intestinal volvulus in cerebral palsy. ( 30237988 )
2018
37
Sigmoid volvulus due to Chagas disease. ( 30638352 )
2018
38
Gallbladder volvulus-acute cholecystitis 'with a twist'. ( 30473760 )
2018
39
Pouch Volvulus in Patients Having Undergone Restorative Proctocolectomy for Ulcerative Colitis: A Case Series. ( 29664798 )
2018
40
Dolichocolon revisited: An inborn anatomic variant with redundancies causing constipation and volvulus. ( 29492185 )
2018
41
Onchocerca volvulus as a risk factor for developing epilepsy in onchocerciasis endemic regions in the Democratic Republic of Congo: a case control study. ( 30293530 )
2018
42
A Prospective Evaluation of a Modified Belt-Loop Gastropexy in 100 Dogs with Gastric Dilatation-Volvulus. ( 30040446 )
2018
43
Prognostic value of canine pancreatic lipase immunoreactivity and lipase activity in dogs with gastric dilatation-volvulus. ( 30226861 )
2018
44
Comparison of saphenous and cephalic blood lactate concentrations in dogs with gastric dilatation and volvulus: 45 cases. ( 30363379 )
2018
45
Diagnosis of chronic gastric instability using computed tomography in a Great Dane that progressed to gastric dilatation and volvulus: a literature review and case report. ( 30425956 )
2018
46
Small bowel gastrointestinal stromal tumor disguised as an adnexal mass: a source for midgut volvulus. ( 29992009 )
2018
47
Worsening anemia associated with volvulus in a stable neonate with intestinal obstruction. ( 30584174 )
2018
48
Epidemiological study on intestinal volvulus without malrotation in VLBW infants. ( 30262462 )
2018
49
Onchocerca volvulus infection and serological prevalence, ocular onchocerciasis and parasite transmission in northern and central Togo after decades of Simulium damnosum s.l. vector control and mass drug administration of ivermectin. ( 29494606 )
2018
50
Fetal Midgut Volvulus with Meconium Peritonitis Detected on Prenatal Ultrasound. ( 29854513 )
2018

Variations for Intestinal Volvulus

Expression for Intestinal Volvulus

Search GEO for disease gene expression data for Intestinal Volvulus.

Pathways for Intestinal Volvulus

GO Terms for Intestinal Volvulus

Cellular components related to Intestinal Volvulus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 EKC/KEOPS complex GO:0000408 8.8 LAGE3 TP53RK TPRKB

Biological processes related to Intestinal Volvulus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tRNA processing GO:0008033 8.8 LAGE3 TP53RK TPRKB

Molecular functions related to Intestinal Volvulus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.32 ATG16L1 CALR IL5 KCNE1 LAGE3 LHFPL5

Sources for Intestinal Volvulus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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