MCID: INT052
MIFTS: 43

Intestinal Volvulus

Categories: Gastrointestinal diseases

Aliases & Classifications for Intestinal Volvulus

MalaCards integrated aliases for Intestinal Volvulus:

Name: Intestinal Volvulus 12 45 15 17 74
Volvulus 12 30 56 15
Twist of Intestine, Bowel, or Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8445
ICD9CM 36 560.2
MeSH 45 D045822
NCIt 51 C98963
SNOMED-CT 69 90738007 9707006
ICD10 34 K56.2
UMLS 74 C0042961

Summaries for Intestinal Volvulus

MalaCards based summary : Intestinal Volvulus, also known as volvulus, is related to onchocerciasis and hernia, hiatus. An important gene associated with Intestinal Volvulus is TWIST1 (Twist Family BHLH Transcription Factor 1), and among its related pathways/superpathways is tRNA processing. The drugs Ivermectin and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and spleen, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 A volvulus is when a loop of intestine twists around itself and the mesentery that supports it,... more...

Related Diseases for Intestinal Volvulus

Diseases related to Intestinal Volvulus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 251)
# Related Disease Score Top Affiliating Genes
1 onchocerciasis 32.8 CALR IL5
2 hernia, hiatus 30.8 LAGE3 TPRKB
3 filarial elephantiasis 29.6 IL5 SRCIN1
4 volvulus of midgut 12.2
5 duodenojejunal atresia with volvulus, absent dorsal mesentery, and absent superior mesenteric artery 12.1
6 gastric volvulus, intrathoracic 12.1
7 nodding syndrome 11.4
8 abdominal cystic lymphangioma 11.4
9 duodenal atresia 11.2
10 short bowel syndrome 11.2
11 gastric dilatation 10.7
12 wandering spleen 10.4
13 megacolon 10.2
14 yemenite deaf-blind hypopigmentation syndrome 10.2
15 duodenal obstruction 10.2
16 senile ectropion 10.2 SRCIN1 TWIST1
17 lymphangioma 10.1
18 situs inversus 10.1
19 chilaiditi syndrome 10.1
20 colitis 10.1
21 appendicitis 10.1
22 degos 'en cocarde' erythrokeratoderma 10.1
23 filariasis 10.0
24 pancreatitis 10.0
25 cardiac tamponade 10.0
26 epilepsy 10.0
27 cholecystitis 10.0
28 constipation 10.0
29 acanthocheilonemiasis 10.0
30 lipomatosis, multiple 10.0
31 cystic fibrosis 10.0
32 pleomorphic lipoma 10.0
33 intestinal atresia 10.0
34 bladder calculus 10.0 LAGE3 TP53RK TPRKB
35 leptin deficiency or dysfunction 10.0
36 crohn's disease 10.0
37 ulcerative colitis 10.0
38 pyloric stenosis 10.0
39 schistosomiasis 10.0
40 colonic pseudo-obstruction 10.0
41 intestinal pseudo-obstruction 10.0
42 ogilvie syndrome 10.0
43 lower urinary tract calculus 9.9 LAGE3 TP53RK TPRKB
44 galloway-mowat syndrome 9.9 LAGE3 TP53RK TPRKB
45 hypertelorism 9.9 TPRKB TWIST1
46 keratitis, hereditary 9.9
47 leiomyoma, uterine 9.9
48 marfan syndrome 9.9
49 tracheoesophageal fistula with or without esophageal atresia 9.9
50 ascites, chylous 9.9

Comorbidity relations with Intestinal Volvulus via Phenotypic Disease Network (PDN): (show all 14)


Active Peptic Ulcer Disease Acute Cystitis
Acute Vascular Insufficiency of Intestine Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Intestinal Obstruction Paralytic Ileus
Parkinson Disease, Late-Onset Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder

Graphical network of the top 20 diseases related to Intestinal Volvulus:



Diseases related to Intestinal Volvulus

Symptoms & Phenotypes for Intestinal Volvulus

GenomeRNAi Phenotypes related to Intestinal Volvulus according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.44 QRSL1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.44 TP53RK
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.44 QRSL1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.44 TP53RK
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.44 TP53RK
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.44 QRSL1 TP53RK TWIST1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.44 TP53RK
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.44 QRSL1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.44 TP53RK
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.44 TWIST1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.44 QRSL1

Drugs & Therapeutics for Intestinal Volvulus

Drugs for Intestinal Volvulus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 70288-86-7 6474909
2
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
3 Antiparasitic Agents Phase 3,Phase 2,Not Applicable
4 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
5 Milbemycin Phase 3,Phase 2
6 Anthelmintics Phase 3,Phase 2
7 Vitamins Phase 3,Not Applicable
8 Antiprotozoal Agents Phase 3,Phase 2
9 Antimitotic Agents Phase 3
10
Azithromycin Approved Phase 2 83905-01-5 447043 55185
11
Rifampicin Approved Phase 2 13292-46-1 5381226 5458213
12
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
13 Antibiotics, Antitubercular Phase 2
14 Antitubercular Agents Phase 2
15 Cytochrome P-450 CYP3A Inducers Phase 2
16 Nucleic Acid Synthesis Inhibitors Phase 2
17 Anti-Bacterial Agents Phase 2
18 Antimalarials Phase 2
19
Diethylcarbamazine Approved, Investigational, Vet_approved 90-89-1 3052
20
Suramin Investigational 145-63-1 5361
21 Cola Not Applicable
22 lysine Not Applicable
23 Micronutrients Not Applicable
24 Pharmaceutical Solutions Not Applicable
25 Trace Elements Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection Completed NCT00790998 Phase 3 Moxidectin;Ivermectin
2 IVM Alone vs ALB + IVM Against Onchocerciasis Completed NCT03238131 Phase 3 Ivermectin;Albendazole
3 Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana Completed NCT02078024 Phase 3 IVM plus ALB;IVM
4 Safety and Efficacy of Annual or Biannual Doses of Moxidectin or Ivermectin for Onchocerciasis Not yet recruiting NCT03876262 Phase 3 Moxidectin;Ivermectin
5 Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed NCT00300768 Phase 2 2 mg moxidectin;ivermectin 150 mcg/kg;4 mg moxidectin;8 mg moxidectin
6 Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness Completed NCT00127504 Phase 2 Rifampin;Azithromycin
7 Doxycycline for the Treatment of Nodding Syndrome Recruiting NCT02850913 Phase 2 Doxycycline
8 Pediatric Pharmacokinetics And Safety Study Of Moxidectin Withdrawn NCT01035619 Phase 2 moxidectin
9 A RETROspective Data Collection of comPRESSion Anastomosis Using the ColonRing Unknown status NCT01880918
10 Prenatal Diagnosis of Antenatal Midgut Volvulus: Specific Ultrasound Features Completed NCT03362450
11 Best Management of Sigmoid Volvulus: A Prospective Randomized Trial Completed NCT01682395 Not Applicable
12 Prenatal Ultrasound Screening of Intestinal Malrotation With a Higher Risk of Volvulus Completed NCT03356314
13 Prevalence of LF Infection in Districts Not Included in LF Control Activities Completed NCT03131401
14 Heterotaxy Syndrome and Intestinal Rotation Abnormalities - A Prospective Study Completed NCT01591928
15 Determination of Lysine Requirement in the Parenterally Fed Neonate Completed NCT00779753 Not Applicable
16 Data Collection of Patients Treated With the ColonRing™ for the Creation of Circular Compression Anastomosis Completed NCT01301417
17 Clinical Features and Potential Etiology of Epilepsy and Nodding Syndrome in the Mahenge Area, Ulanga District Recruiting NCT03653975
18 Host Response to Infection and Treatment in Filarial Diseases Recruiting NCT00001230
19 Stapled Anastomosis Versus Hand-sewn for Neonate With Intestinal Atresia Recruiting NCT03754907 Not Applicable
20 Evaluation of the Risks and Benefits of Abdominal Massage Treatment in Neonatalogy in Premature Children Recruiting NCT03681782
21 Ocular Changes After Ivermectin - (DOLF IVM/Oncho) Active, not recruiting NCT03517462 Not Applicable Ivermectin 3Mg Tab
22 Regional Blood Saturation Levels in Gastroschisis Active, not recruiting NCT03533439

Search NIH Clinical Center for Intestinal Volvulus

Cochrane evidence based reviews: intestinal volvulus

Genetic Tests for Intestinal Volvulus

Genetic tests related to Intestinal Volvulus:

# Genetic test Affiliating Genes
1 Volvulus 30

Anatomical Context for Intestinal Volvulus

MalaCards organs/tissues related to Intestinal Volvulus:

42
Colon, Small Intestine, Spleen, Skin, Liver, Testes, T Cells

Publications for Intestinal Volvulus

Articles related to Intestinal Volvulus:

(show top 50) (show all 3011)
# Title Authors Year
1
Rare occurrence of small bowel volvulus following laparoscopic appendicectomy for perforated appendicitis. ( 30697417 )
2019
2
Integrated seroprevalence-based assessment of Wuchereria bancrofti and Onchocerca volvulus in two lymphatic filariasis evaluation units of Mali with the SD Bioline Onchocerciasis/LF IgG4 Rapid Test. ( 30699120 )
2019
3
Transient distal renal tubular acidosis in a dog with gastric-dilatation-volvulus. ( 30705453 )
2019
4
Fetal Primary Small Bowel Volvulus Associated with Acute Gastric Dilatation Detected by Ultrasonography. ( 30728342 )
2019
5
Recurrent gastric volvulus associated with a gastrointestinal stromal tumor: A case report. ( 30954704 )
2019
6
Midgut volvulus is a rare cause of intestinal obstruction in adults: A case report. ( 31003093 )
2019
7
Secondary pneumatosis cystoides intestinalis complicated by intestinal volvulus: A case report and literature review. ( 30661712 )
2019
8
Experimental study on prophylactic effects of vardenafil in ischemia-reperfusion model with intestinal volvulus injury in rats. ( 30885562 )
2019
9
Small-bowel volvulus caused by mesenteric lymphangioma. ( 31077830 )
2019
10
Small Bowel Volvulus Caused by Small Intestinal B Cell Lymphoma. ( 30788713 )
2019
11
Primary midgut volvulus in a patient with Marfan syndrome. ( 30788104 )
2019
12
Transverse colon volvulus in a patient with sickle cell disease. ( 30852505 )
2019
13
Hirschsprung disease in an adult with intestinal malrotation and volvulus: an exceptional association. ( 31030669 )
2019
14
Intra-abdominal lymphatic tuberculosis as a rare case of small intestine volvulus. ( 31065355 )
2019
15
Cecal volvulus in long-distance runners: A proposed mechanism. ( 30057073 )
2019
16
Sigmoid volvulus and the coffee bean sign. ( 30165418 )
2019
17
Gastric tube volvulus following an Ivor-Lewis esophagectomy. ( 30286640 )
2019
18
Outcomes of first-line endoscopic management for patients with sigmoid volvulus. ( 30377062 )
2019
19
CT of Gastric Volvulus: Interobserver Reliability, Radiologists' Accuracy, and Imaging Findings. ( 30403524 )
2019
20
Neurological manifestations in Onchocerca volvulus infection: A review. ( 30458251 )
2019
21
Comments on Contemporary Management of Sigmoid Volvulus. ( 30465185 )
2019
22
Prenatal diagnosis of antenatal midgut volvulus: Specific ultrasound features. ( 30536936 )
2019
23
Omega sign: Radiological appearance of sigmoid volvulus. ( 30628190 )
2019
24
Gastric volvulus: unraveling the diagnosis with MPRs. ( 30644001 )
2019
25
Development of a preliminary in vitro drug screening assay based on a newly established culturing system for pre-adult fifth-stage Onchocerca volvulus worms. ( 30653499 )
2019
26
Acute gastric volvulus with pneumatosis intestinalis and portal venous gas secondary to hiatus hernia induced gastric outlet obstruction. ( 30675980 )
2019
27
Patent infections with soil-transmitted helminths and Schistosoma mansoni are not associated with increased prevalence of antibodies to the Onchocerca volvulus peptide epitopes OvMP-1 and OvMP-23. ( 30691520 )
2019
28
Very rare case of synchronous volvulus of the sigmoid colon and caecum causing large-bowel obstruction. ( 30696645 )
2019
29
Ileal conduit volvulus: rare complication of urinary diversion. ( 30696652 )
2019
30
A Multi-institutional Case Series With Review of Point-of-Care Ultrasound to Diagnose Malrotation and Midgut Volvulus in the Pediatric Emergency Department. ( 30702647 )
2019
31
Target and Whirl Signs: Volvulus of Intussuscepted Colon in an Infant. ( 30710705 )
2019
32
Single-incision laparoscopic gastropexy for mesentero-axial gastric volvulus. ( 30715642 )
2019
33
Gastroscope guidewire volvulus tube decompression. ( 30719575 )
2019
34
Second-trimester presentation of midgut volvulus without intestinal malrotation. ( 30761657 )
2019
35
Atraumatic splenic rupture secondary to appendicular perforation by cecal volvulus. ( 30768070 )
2019
36
Progressive atrophy in a deformed liver as a contributor to sigmoid volvulus. ( 30796695 )
2019
37
An unusual case of perisplenic small bowel volvulus after laparoscopic Roux En Y gastric bypass. ( 30800275 )
2019
38
Long-term outcomes of ultrashort bowel syndrome due to malrotation with midgut volvulus managed at an interdisciplinary pediatric intestinal rehabilitation center. ( 30826119 )
2019
39
Gallbladder volvulus: A rare cause of acute gallbladder distension. ( 30873662 )
2019
40
Sigmoid volvulus: Comorbidity with sigmoid gangrene. ( 30881440 )
2019
41
Ventricular tachycardia in a patient with sigmoid volvulus on treatment with donepezil. ( 30896286 )
2019
42
Management and outcomes of gastric volvulus in children: a systematic review. ( 30900131 )
2019
43
Blackflies in the ointment: O. volvulus vector biting can be significantly reduced by the skin-application of mineral oil during human landing catches. ( 30933979 )
2019
44
Sigmoid volvulus: avoiding recurrence. ( 30955105 )
2019
45
A Case of Mesentero-axial Type of Acute Gastric Volvulus Successfully Reduced by a Balloon-assisted Endoscopy. ( 30963522 )
2019
46
Management of acute sigmoid volvulus in a provincial centre-a 20-year experience. ( 30973858 )
2019
47
Organoaxial gastric volvulus: a rare cause of an acute abdomen. ( 30984512 )
2019
48
Sigmoid volvulus: identifying patients requiring emergency surgery with the dark torsion knot sign. ( 31028443 )
2019
49
Comment on 'Outcomes of first-line endoscopic management for patients with sigmoid volvulus'. ( 31036470 )
2019
50
Primary Segmental Volvulus of Small Intestine: Surgical Perspectives According to Age at Diagnosis. ( 31058122 )
2019

Variations for Intestinal Volvulus

Expression for Intestinal Volvulus

Search GEO for disease gene expression data for Intestinal Volvulus.

Pathways for Intestinal Volvulus

GO Terms for Intestinal Volvulus

Cellular components related to Intestinal Volvulus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 EKC/KEOPS complex GO:0000408 8.8 LAGE3 TP53RK TPRKB

Biological processes related to Intestinal Volvulus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tRNA processing GO:0008033 8.8 LAGE3 TP53RK TPRKB

Molecular functions related to Intestinal Volvulus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.36 ATG16L1 CALR IL5 KCNE1 LAGE3 LHFPL5

Sources for Intestinal Volvulus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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