MCID: INT052
MIFTS: 38

Intestinal Volvulus

Categories: Gastrointestinal diseases

Aliases & Classifications for Intestinal Volvulus

MalaCards integrated aliases for Intestinal Volvulus:

Name: Intestinal Volvulus 12 44 15 73
Volvulus 12 29 55 15
Twist of Intestine, Bowel, or Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8445
ICD10 33 K56.2
ICD9CM 35 560.2
MeSH 44 D045822
NCIt 50 C98963
SNOMED-CT 68 90738007 9707006
UMLS 73 C0042961

Summaries for Intestinal Volvulus

MalaCards based summary : Intestinal Volvulus, also known as volvulus, is related to onchocerciasis and hernia, hiatus. An important gene associated with Intestinal Volvulus is TWIST1 (Twist Family BHLH Transcription Factor 1), and among its related pathways/superpathways is tRNA processing. The drugs Ivermectin and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver.

Wikipedia : 76 A volvulus is when a loop of intestine twists around itself and the mesentery that supports it,... more...

Related Diseases for Intestinal Volvulus

Diseases related to Intestinal Volvulus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 onchocerciasis 32.8 CALR IL5
2 hernia, hiatus 30.4 LAGE3 TPRKB WDR73
3 filarial elephantiasis 29.3 IL5 SRCIN1
4 volvulus of midgut 12.2
5 duodenojejunal atresia with volvulus, absent dorsal mesentery, and absent superior mesenteric artery 12.1
6 gastric volvulus, intrathoracic 12.0
7 nodding syndrome 11.4
8 abdominal cystic lymphangioma 11.4
9 duodenal atresia 11.2
10 short bowel syndrome 11.2
11 gastric dilatation 10.7
12 wandering spleen 10.3
13 megacolon 10.2
14 duodenal obstruction 10.2
15 ischemia 10.2
16 senile ectropion 10.1 SRCIN1 TWIST1
17 meckel diverticulum 10.1
18 chilaiditi syndrome 10.1
19 lymphangioma 10.1
20 degos 'en cocarde' erythrokeratoderma 10.1
21 colitis 10.0
22 situs inversus 10.0
23 cholecystitis 10.0
24 appendicitis 10.0
25 cystic fibrosis 10.0
26 intestinal atresia 10.0
27 ulcerative colitis 10.0
28 cardiac tamponade 10.0
29 pneumatosis cystoides intestinalis 10.0
30 epilepsy 10.0
31 constipation 10.0
32 colonic pseudo-obstruction 10.0
33 intestinal pseudo-obstruction 10.0
34 acanthocheilonemiasis 10.0
35 intestinal schistosomiasis 9.9 IL5 SRCIN1
36 leiomyoma, uterine 9.9
37 ascites, chylous 9.9
38 diaphragmatic eventration 9.9
39 mansonelliasis 9.9
40 pyloric stenosis 9.9
41 lipomatosis 9.9
42 pancreatitis 9.9
43 dextrocardia with situs inversus 9.9
44 necatoriasis 9.9 CALR IL5
45 anterior scleritis 9.8 IL5 SRCIN1
46 norwegian scabies 9.8 IL5 KCNE1 TWIST1
47 diaphragmatic hernia, congenital 9.8
48 intussusception 9.8
49 lipomatosis, multiple 9.8
50 pelvic organ prolapse 9.8

Comorbidity relations with Intestinal Volvulus via Phenotypic Disease Network (PDN): (show all 14)


Active Peptic Ulcer Disease Acute Cystitis
Acute Vascular Insufficiency of Intestine Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Intestinal Obstruction Paralytic Ileus
Parkinson Disease, Late-Onset Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder

Graphical network of the top 20 diseases related to Intestinal Volvulus:



Diseases related to Intestinal Volvulus

Symptoms & Phenotypes for Intestinal Volvulus

Drugs & Therapeutics for Intestinal Volvulus

Drugs for Intestinal Volvulus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 70288-86-7 6474909
2
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
3 Milbemycin Phase 3,Phase 2
4 Antiparasitic Agents Phase 3,Phase 2,Not Applicable
5 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
6 Anthelmintics Phase 3,Phase 2
7 Vitamins Phase 3,Not Applicable
8 Antiprotozoal Agents Phase 3,Phase 2
9 Antimitotic Agents Phase 3
10
Azithromycin Approved Phase 2 83905-01-5 55185 447043
11
Rifampicin Approved Phase 2 13292-46-1 5458213 5381226
12
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
13 Antitubercular Agents Phase 2
14 Antibiotics, Antitubercular Phase 2
15 Cytochrome P-450 CYP3A Inducers Phase 2
16 Nucleic Acid Synthesis Inhibitors Phase 2
17 Anti-Bacterial Agents Phase 2
18 Antimalarials Phase 2
19
Diethylcarbamazine Approved, Investigational, Vet_approved 90-89-1 3052
20
Suramin Investigational 145-63-1 5361
21 Cola Not Applicable
22 Micronutrients Not Applicable
23 Trace Elements Not Applicable
24 lysine Not Applicable
25 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection Completed NCT00790998 Phase 3 Moxidectin;Ivermectin
2 IVM Alone vs ALB + IVM Against Onchocerciasis Completed NCT03238131 Phase 3 Ivermectin;Albendazole
3 Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana Active, not recruiting NCT02078024 Phase 3 IVM plus ALB;IVM
4 Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed NCT00300768 Phase 2 2 mg moxidectin;ivermectin 150 mcg/kg;4 mg moxidectin;8 mg moxidectin
5 Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness Completed NCT00127504 Phase 2 Rifampin;Azithromycin
6 Doxycycline for the Treatment of Nodding Syndrome Recruiting NCT02850913 Phase 2 Doxycycline
7 Pediatric Pharmacokinetics And Safety Study Of Moxidectin Withdrawn NCT01035619 Phase 2 moxidectin
8 A RETROspective Data Collection of comPRESSion Anastomosis Using the ColonRing Unknown status NCT01880918
9 Prenatal Diagnosis of Antenatal Midgut Volvulus: Specific Ultrasound Features Completed NCT03362450
10 Best Management of Sigmoid Volvulus: A Prospective Randomized Trial Completed NCT01682395 Not Applicable
11 Prenatal Ultrasound Screening of Intestinal Malrotation With a Higher Risk of Volvulus Completed NCT03356314
12 Prevalence of LF Infection in Districts Not Included in LF Control Activities Completed NCT03131401
13 Heterotaxy Syndrome and Intestinal Rotation Abnormalities - A Prospective Study Completed NCT01591928
14 Determination of Lysine Requirement in the Parenterally Fed Neonate Completed NCT00779753 Not Applicable
15 Data Collection of Patients Treated With the ColonRing™ for the Creation of Circular Compression Anastomosis Completed NCT01301417
16 Clinical Features and Potential Etiology of Epilepsy and Nodding Syndrome in the Mahenge Area, Ulanga District Recruiting NCT03653975
17 Host Response to Infection and Treatment in Filarial Diseases Recruiting NCT00001230
18 Stapled Anastomosis Versus Hand-sewn for Neonate With Intestinal Atresia Recruiting NCT03754907 Not Applicable
19 Evaluation of the Risks and Benefits of Abdominal Massage Treatment in Neonatalogy in Premature Children Recruiting NCT03681782
20 Regional Blood Saturation Levels in Gastroschisis Active, not recruiting NCT03533439
21 Ocular Changes After Ivermectin - (DOLF IVM/Oncho) Enrolling by invitation NCT03517462 Not Applicable Ivermectin 3Mg Tab

Search NIH Clinical Center for Intestinal Volvulus

Cochrane evidence based reviews: intestinal volvulus

Genetic Tests for Intestinal Volvulus

Genetic tests related to Intestinal Volvulus:

# Genetic test Affiliating Genes
1 Volvulus 29

Anatomical Context for Intestinal Volvulus

MalaCards organs/tissues related to Intestinal Volvulus:

41
Colon, Small Intestine, Liver, Spleen, Lung, Skin, Appendix

Publications for Intestinal Volvulus

Articles related to Intestinal Volvulus:

(show top 50) (show all 910)
# Title Authors Year
1
Role of the ultrasonographic 'whirlpool sign' in intestinal volvulus: a systematic review and meta-analysis. ( 29740967 )
2018
2
Is isomerism a risk factor for intestinal volvulus? ( 29605269 )
2018
3
Primary small intestinal volvulus after laparoscopic rectopexy for rectal prolapse. ( 29388327 )
2018
4
Primary intestinal aspergillosis resulting in acute intestinal volvulus after autologous stem cell transplantation in a patient with relapsed non-Hodgkin lymphoma: report on a rare infectious complication and a review of the literature. ( 30238855 )
2018
5
Acute gastric volvulus presenting as a pseudo cardiac tamponade. ( 30209140 )
2018
6
The lethal twist - a story of unspoken pain: small intestinal volvulus in cerebral palsy. ( 30237988 )
2018
7
Chilaiditi syndrome complicated by a sigmoid volvulus and hepatic displacement. ( 29278005 )
2018
8
Gallbladder volvulus-acute cholecystitis 'with a twist'. ( 30473760 )
2018
9
Dolichocolon revisited: An inborn anatomic variant with redundancies causing constipation and volvulus. ( 29492185 )
2018
10
Onchocerca volvulus as a risk factor for developing epilepsy in onchocerciasis endemic regions in the Democratic Republic of Congo: a case control study. ( 30293530 )
2018
11
The canine gut microbiome is associated with higher risk of gastric dilatation-volvulus and high risk genetic variants of the immune system. ( 29889838 )
2018
12
A Prospective Evaluation of a Modified Belt-Loop Gastropexy in 100 Dogs with Gastric Dilatation-Volvulus. ( 30040446 )
2018
13
Prognostic value of canine pancreatic lipase immunoreactivity and lipase activity in dogs with gastric dilatation-volvulus. ( 30226861 )
2018
14
Comparison of saphenous and cephalic blood lactate concentrations in dogs with gastric dilatation and volvulus: 45 cases. ( 30363379 )
2018
15
Diagnosis of chronic gastric instability using computed tomography in a Great Dane that progressed to gastric dilatation and volvulus: a literature review and case report. ( 30425956 )
2018
16
Small bowel gastrointestinal stromal tumor disguised as an adnexal mass: a source for midgut volvulus. ( 29992009 )
2018
17
Epidemiological study on intestinal volvulus without malrotation in VLBW infants. ( 30262462 )
2018
18
Onchocerca volvulus infection and serological prevalence, ocular onchocerciasis and parasite transmission in northern and central Togo after decades of Simulium damnosum s.l. vector control and mass drug administration of ivermectin. ( 29494606 )
2018
19
Acute chylous peritonitis as a result of jejunal volvulus and small bowel obstruction from a congenital band adhesion. ( 29651811 )
2018
20
Fetal Midgut Volvulus with Meconium Peritonitis Detected on Prenatal Ultrasound. ( 29854513 )
2018
21
Schistosomiasis Presenting as Recurring Sigmoid Volvulus in a Danish Man With an Inconspicuous Travel History-A Case Report. ( 29644249 )
2018
22
Efficacy and safety of cardioversion with continuous landiolol infusion for atrial tachyarrhythmia in an inflammatory state caused by volvulus in a child with TARP syndrome and postoperative tetralogy of Fallot. ( 30167019 )
2018
23
Pouch Volvulus in Patients Having Undergone Restorative Proctocolectomy for Ulcerative Colitis: A Case Series. ( 29664798 )
2018
24
Cecal Volvulus following a Right Nephrectomy for Wilms' Tumor: Should We Need to Close the Lateral Peritoneum? ( 29318103 )
2018
25
A 13-Year-Old with Coexistence of Gastric Volvulus and Leprosy: A Case Report of Two Rare Entities. ( 30186647 )
2018
26
Cecal volvulus with gangrene following Mitrofanoff procedure. ( 30140613 )
2018
27
Primary gastric volvulus: a report of two cases. ( 30151116 )
2018
28
Gastric volvulus through Morgagni hernia and intestinal diverticulosis in an adult patient: a case report. ( 30157820 )
2018
29
Sigmoid volvulus & the coffee bean sign. ( 30165418 )
2018
30
Linear epitopes in Onchocerca volvulus vaccine candidate proteins and excretory-secretory proteins. ( 30188578 )
2018
31
Comment on "Volvulus of the sigmoid colon is associated with hypotrophy of the left lateral segment of the liver and the absence of sigmoid diverticulum". ( 30201475 )
2018
32
Investigation of potential risk factors for mesenteric volvulus in military working dogs. ( 30211640 )
2018
33
Cecal volvulus caused by internal herniation after roux-en-y gastric bypass surgery. ( 30214713 )
2018
34
Gastric band tubing causing cecal volvulus. ( 30217429 )
2018
35
Response to comments on "Volvulus of the sigmoid colon is associated with hypotrophy of the left lateral segment of the liver and the absence of sigmoid diverticulum". ( 30220587 )
2018
36
Volvulus. ( 30243456 )
2018
37
Prediction and validation of the structural features of Ov58GPCR, an immunogenic determinant of Onchocerca volvulus. ( 30256790 )
2018
38
From Endoscopic Detorsion to Sigmoid Colectomy-The Art of Managing Patients with Sigmoid Volvulus: A Survey of the Members of the American Society of Colon and Rectal Surgeons. ( 30268187 )
2018
39
Gastric tube volvulus following an Ivor-Lewis esophagectomy. ( 30286640 )
2018
40
Horseshoe sign: Sigmoid volvulus. ( 30309120 )
2018
41
Sigmoid Volvulus in Children: Diagnosis and Therapeutic Challenge. ( 30320166 )
2018
42
Outcomes of first-line endoscopic management for patients with sigmoid volvulus. ( 30377062 )
2018
43
CT of Gastric Volvulus: Interobserver Reliability, Radiologists' Accuracy, and Imaging Findings. ( 30403524 )
2018
44
Mesenteroaxial Gastric Volvulus Diagnosed with MR Imaging during the Early Stages of Pregnancy. ( 30404979 )
2018
45
A case report of a rare and challenging gangrenous splenic flexure volvulus in a pregnant patient. ( 30408739 )
2018
46
Chronic gastric volvulus. ( 30430480 )
2018
47
Synchronous volvulus of the sigmoid and transverse colon in a 26-year-old male. ( 30443313 )
2018
48
Compound volvulus: a case report and literature review. ( 30443321 )
2018
49
Cecal Volvulus: An Evolving Disease. ( 30454520 )
2018
50
Laparoscopic repositioning of chronic gastric volvulus in a dog. ( 30456979 )
2018

Variations for Intestinal Volvulus

Expression for Intestinal Volvulus

Search GEO for disease gene expression data for Intestinal Volvulus.

Pathways for Intestinal Volvulus

GO Terms for Intestinal Volvulus

Cellular components related to Intestinal Volvulus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 EKC/KEOPS complex GO:0000408 8.8 LAGE3 TP53RK TPRKB

Biological processes related to Intestinal Volvulus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tRNA processing GO:0008033 8.8 LAGE3 TP53RK TPRKB

Sources for Intestinal Volvulus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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