MCID: INT052
MIFTS: 44

Intestinal Volvulus

Categories: Gastrointestinal diseases

Aliases & Classifications for Intestinal Volvulus

MalaCards integrated aliases for Intestinal Volvulus:

Name: Intestinal Volvulus 12 44 15 17 72
Volvulus 12 29 55 15 33
Twist of Intestine, Bowel, or Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8445
ICD9CM 35 560.2
MeSH 44 D045822
NCIt 50 C98963
SNOMED-CT 68 90738007 9707006
ICD10 33 K56.2
UMLS 72 C0042961

Summaries for Intestinal Volvulus

MalaCards based summary : Intestinal Volvulus, also known as volvulus, is related to onchocerciasis and hernia, hiatus. An important gene associated with Intestinal Volvulus is PARP8 (Poly(ADP-Ribose) Polymerase Family Member 8), and among its related pathways/superpathways is tRNA processing. The drugs Ivermectin and Antiparasitic Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and skin.

Wikipedia : 75 A volvulus is when a loop of intestine twists around itself and the mesentery that supports it,... more...

Related Diseases for Intestinal Volvulus

Diseases related to Intestinal Volvulus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 462)
# Related Disease Score Top Affiliating Genes
1 onchocerciasis 32.9 IL5 CALR
2 hernia, hiatus 31.2 TPRKB LAGE3
3 filarial elephantiasis 30.3 SRCIN1 IL5
4 intestinal schistosomiasis 29.4 SRCIN1 IL5
5 duodenojejunal atresia with volvulus, absent dorsal mesentery, and absent superior mesenteric artery 12.4
6 volvulus of midgut 12.3
7 gastric volvulus, intrathoracic 12.3
8 short bowel syndrome 11.7
9 nodding syndrome 11.5
10 abdominal cystic lymphangioma 11.5
11 duodenal atresia 11.3
12 gastric dilatation 10.8
13 constipation 10.7
14 yemenite deaf-blind hypopigmentation syndrome 10.6
15 intestinal obstruction 10.5
16 filariasis 10.5
17 wandering spleen 10.5
18 cholecystitis 10.4
19 appendicitis 10.4
20 keratitis, hereditary 10.4
21 diaphragmatic eventration 10.3
22 gastroesophageal reflux 10.3
23 diarrhea 10.3
24 48,xyyy 10.3
25 peritonitis 10.2
26 colitis 10.2
27 ischemia 10.2
28 situs inversus 10.2
29 chilaiditi syndrome 10.2
30 intestinal atresia 10.2
31 leptin deficiency or dysfunction 10.2
32 pancreatitis 10.2
33 ovarian cyst 10.2
34 abdominal wall defect 10.2
35 gastroschisis 10.2
36 loiasis 10.2
37 peptic ulcer disease 10.2
38 dysphagia 10.2
39 meckel diverticulum 10.1
40 pyloric stenosis 10.1
41 ascaridiasis 10.1
42 colonic pseudo-obstruction 10.1
43 ulcerative colitis 10.1
44 ascaris lumbricoides infection 10.1
45 aspiration pneumonia 10.1
46 intestinal pseudo-obstruction 10.1
47 cytokine deficiency 10.1
48 lipomatosis, multiple 10.1
49 jejunal atresia 10.1
50 pleomorphic lipoma 10.1

Comorbidity relations with Intestinal Volvulus via Phenotypic Disease Network (PDN): (show all 14)


Active Peptic Ulcer Disease Acute Cystitis
Acute Vascular Insufficiency of Intestine Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Intestinal Obstruction Paralytic Ileus
Parkinson Disease, Late-Onset Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder

Graphical network of the top 20 diseases related to Intestinal Volvulus:



Diseases related to Intestinal Volvulus

Symptoms & Phenotypes for Intestinal Volvulus

Drugs & Therapeutics for Intestinal Volvulus

Drugs for Intestinal Volvulus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 4 70288-86-7 6474909
2 Antiparasitic Agents Phase 4
3 Anti-Infective Agents Phase 4
4 Anticonvulsants Phase 4
5 Vitamins Phase 4
6 Pharmaceutical Solutions Phase 4
7 Parenteral Nutrition Solutions Phase 4
8 Fat Emulsions, Intravenous Phase 4
9 Soy Bean Phase 4
10 Soybean oil, phospholipid emulsion Phase 4
11 Liver Extracts Phase 4
12
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
13 Tubulin Modulators Phase 3
14 Antimitotic Agents Phase 3
15 Milbemycin Phase 3
16 Anthelmintics Phase 3
17
Valproic acid Approved, Investigational Phase 2 99-66-1 3121
18
Phenytoin Approved, Vet_approved Phase 2 57-41-0 1775
19
Rifampicin Approved Phase 2 13292-46-1 5381226 5458213
20
Azithromycin Approved Phase 2 83905-01-5 447043 55185
21
Furosemide Approved, Vet_approved Phase 2 54-31-9 3440
22
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
23
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2 65-23-6 1054
24
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
25 Kava Approved, Investigational, Nutraceutical Phase 2 9000-38-8
26 Central Nervous System Depressants Phase 2
27 Neurotransmitter Agents Phase 2
28 Sodium Channel Blockers Phase 2
29 Tranquilizing Agents Phase 2
30 Micronutrients Phase 2
31 Trace Elements Phase 2
32 GABA Agents Phase 2
33 Diuretics, Potassium Sparing Phase 2
34 Antimanic Agents Phase 2
35 Vitamin B9 Phase 2
36 Vitamin B Complex Phase 2
37 Folate Phase 2
38 Vitamin B 6 Phase 2
39 Nutrients Phase 2
40 Psychotropic Drugs Phase 2
41 Antitubercular Agents Phase 2
42 Antibiotics, Antitubercular Phase 2
43 Nucleic Acid Synthesis Inhibitors Phase 2
44 Cytochrome P-450 CYP3A Inducers Phase 2
45 Cytochrome P-450 Enzyme Inducers Phase 2
46 diuretics Phase 2
47 Anti-Bacterial Agents Phase 2
48 Antiprotozoal Agents Phase 2
49 Antimalarials Phase 2
50
Pyridoxal Experimental, Nutraceutical Phase 2 66-72-8 1050

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy: A Randomized Clinical Trial Completed NCT03052998 Phase 4 Ivermectin
2 Personalized Versus Standardized Parenteral Nutrition for Preterm Infants With a Birth Weight Greater Than 1250 Grams: a Multicenter Randomized Phase IV Clinical Trial Not yet recruiting NCT03693287 Phase 4 Standardized-parenteral nutrition (S-PN);Personalized-parenteral nutrition (P-PN)
3 Low Dose Parenteral Fat for the Prevention of Parenteral Nutrition Associated Cholestasis in Neonates With Congenital/Acquired Gastrointestinal Disorders Terminated NCT01373918 Phase 4 Intralipid;Intralipid
4 A Single-Dose, Ivermectin-Controlled, Double-Blind, Efficacy, Safety And Tolerability Study Of Orally Administered Moxidectin In Subjects Infected With Onchocerca Volvulus Completed NCT00790998 Phase 3 Moxidectin;Ivermectin
5 Comparison of Ivermectin Alone With Albendazole (ALB) Plus Ivermectin (IVM) in Their Efficacy Against Onchocerciasis Completed NCT03238131 Phase 3 Ivermectin;Albendazole
6 A Randomized, Double Blind, Parallel Trial in the Democratic Republic of Congo (DRC) Comparing the Safety and Efficacy of Annual or Biannual Doses of Moxidectin or Ivermectin for Treatment of Onchocerciasis Not yet recruiting NCT03876262 Phase 3 Moxidectin;Ivermectin
7 Treatment of Nodding Syndrome - A Randomized Blinded Placebo-Controlled Crossover Trial of Oral Pyridoxine and Conventional Anti-Epileptic Therapy, in Northern Uganda — 2012 Unknown status NCT01730313 Phase 2 Pyridoxine;Sodium Valproate;Phenytoin;Placebo
8 A Randomized, Single-Ascending Dose, Ivermectin-Controlled, Double-Blind, Safety, Tolerability, Pharmacokinetic, and Efficacy Study Of Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed NCT00300768 Phase 2 2 mg moxidectin;ivermectin 150 mcg/kg;4 mg moxidectin;8 mg moxidectin
9 Trial of Rifampin and Azithromycin for Treatment of Endosymbiotic Bacteria (Wolbachia) in Onchocerca Volvulus in Guatemala Completed NCT00127504 Phase 2 Rifampin;Azithromycin
10 MANAGEMENT OF THE PATIENT WITH ACUTE ABDOMEN SUBMITTED TO URGENT ABDOMINAL SURGERY: a Pilot Randomized Multicentre Study Completed NCT01911702 Phase 2
11 Doxycycline for the Treatment of Nodding Syndrome: A Phase II, Randomised Placebo Controlled Trial Recruiting NCT02850913 Phase 2 Doxycycline
12 A Single-Center, Open-Label, Single-Dose Study To Assess The Pharmacokinetics, Safety, And Tolerability Of Moxidectin In Subjects Aged 4 To 11 Years ( >=12 kg) With Or Without Onchocerca Volvulus Infection Withdrawn NCT01035619 Phase 2 moxidectin
13 A Phase 1, Single-Blind, Randomized, Placebo Controlled, Parallel-Group, Multiple-Dose-Escalation Study to Investigate Safety, Tolerability, and Pharmacokinetics of Emodepside (BAY 44-4400) After Oral Dosing in Healthy Male Subjects Completed NCT03383614 Phase 1 LSF emodepside (BAY 44-4400) oral solution (1mg/mL)
14 A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Potential Effect of a Single Oral Dose of Moxidectin on the Cardiac QT Interval of Healthy Volunteers Completed NCT03012828 Phase 1 Moxidectin
15 Phase1,Randomized,Open-Label,Parallel-Group,Relative Bioavailability Study to Investigate PK,Including Food Effect,Safety and Tolerability of Single Doses of New Immediate Release Tablet Formulations of Emodepside (BAY 44-4400),Compared to Oral Solution,in Healthy Male Subjects Completed NCT03383523 Phase 1 Emodepside (BAY 44-4400)
16 Bariatric Embolization Trial for the Obese Nonsurgical Not yet recruiting NCT03601273 Phase 1
17 Multi Center, Observational, Retrospective Data Collection of Patients Treated With the ColonRing in Routine Clinical Practice. This Study to Continue RETROPRESS Study ID NCT01301417 Unknown status NCT01880918
18 The Effect of Combined General-epidural vs General Anaesthesia on Postoperative Intestinal Function Recovery and Infection in Neonates and Infants Undergoing Gastrointestinal Surgery: a Prospective, Randomised, Controlled Trial Unknown status NCT03056261
19 Probiotics Supplementation and Length of Hospital Stay in Neonates With Gastrointestinal Surgery Unknown status NCT03266315
20 Omegaven for Compassionate Use in the Treatment of Parenteral Nutrition-Associated Liver Disease Approved for marketing NCT03072667 Omegaven
21 Best Management of Sigmoid Volvulus: A Prospective Randomized Trial Completed NCT01682395
22 Prenatal Diagnosis of Antenatal Midgut Volvulus: Specific Ultrasound Features Completed NCT03362450
23 Prenatal Ultrasound Screening of Intestinal Malrotation With a Higher Risk of Volvulus: Value of The Relative Position of The Superior Mesenteric Artery and Vein. Future of the Children With an Antenatal Malrotation Suspicion Completed NCT03356314
24 a RETROspective Data Collection of comPRESSion Anastomosis Using the ColonRing ™ Completed NCT01301417
25 Determination of the Prevalence of LF Infection in Districts Not Included in LF Control Activities and of the Basis for Integrated Implementation of LF - Onchocerciasis Elimination Strategies in Potentially Co-endemic Areas Completed NCT03131401
26 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast Completed NCT02032043 Annual versus Semiannual Albendazole plus Ivermectin MDA
27 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Liberia Completed NCT01905436 Annual versus Semiannual Albendazole plus Ivermectin Mass Drug Administration
28 Health Related Quality of Life of Patients With Abdominal Wall Defects Completed NCT03960320
29 Role of Omega-3 Fish Oil Fatty Acids on Depression Among HIV-seropositive Pregnant Pregnant Women in Nairobi: A Randomized Double-blind Controlled Trial Completed NCT01614249
30 Clinical Features and Potential Etiology of Epilepsy and Nodding Syndrome in the Mahenge Area, Ulanga District Recruiting NCT03653975
31 Host Response to Infection and Treatment in the Filarial Diseases of Humans Recruiting NCT00001230
32 Microfilarial Clearance From the Eye and Ocular Changes Associated With Ivermectin Treatment in Individuals With Onchocerciasis Active, not recruiting NCT03517462 Ivermectin 3Mg Tab
33 Regional Haemoglobin Oxygen Saturation in the Splanchnic Circulation in Neonates With Gastroschisis; Quantifying and Qualifying the Role for Routine Monitoring Active, not recruiting NCT03533439
34 Diagnostic Performance of Antenatal Ultrasound in the Localization of Intestinal Structures Involved in Malrotation With a Higher-risk of Volvulus Not yet recruiting NCT03968107
35 Yield of Colonoscopy in Children With Bleeding Per Rectum Attending Gastrointestinal Endoscopic Unit In Assuit University Children Hospital Not yet recruiting NCT03596320
36 Early Delivery in Fetal Gastroschisis: a Randomized Controlled Trial of Elective Early Delivery Versus Routine Obstetrical Care Terminated NCT01884324
37 Prospective Study of Non-operative Management of SBO Without Nasogastric Tube Placement Withdrawn NCT02530086

Search NIH Clinical Center for Intestinal Volvulus

Cochrane evidence based reviews: intestinal volvulus

Genetic Tests for Intestinal Volvulus

Genetic tests related to Intestinal Volvulus:

# Genetic test Affiliating Genes
1 Volvulus 29

Anatomical Context for Intestinal Volvulus

MalaCards organs/tissues related to Intestinal Volvulus:

41
Colon, Small Intestine, Skin, Liver, Spleen, Testes, Eye

Publications for Intestinal Volvulus

Articles related to Intestinal Volvulus:

(show top 50) (show all 8121)
# Title Authors PMID Year
1
Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells. 9 38
20199697 2010
2
Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM. 9 38
17202370 2007
3
Ivermectin selection on beta-tubulin: evidence in Onchocerca volvulus and Haemonchus contortus. 9 38
17007942 2006
4
Genetic polymorphism of the beta-tubulin gene of Onchocerca volvulus in ivermectin naïve patients from Cameroon, and its relationship with fertility of the worms. 9 38
16197589 2006
5
Onchocerca volvulus-exposed persons fail to produce interferon-gamma in response to O. volvulus antigen but mount proliferative responses with interleukin-5 and IL-13 production that decrease with increasing microfilarial density. 9 38
11930325 2002
6
Characterization and expression of enzymatically active recombinant filarial prolyl 4-hydroxylase. 9 38
11522351 2001
7
Neutrophil accumulation around Onchocerca worms and chemotaxis of neutrophils are dependent on Wolbachia endobacteria. 9 38
11377205 2001
8
Characterization of the heat-shock protein 60 chaperonin from Onchocerca volvulus. 9 38
10779593 2000
9
T cell responses in coinfection with Onchocerca volvulus and the human immunodeficiency virus type 1. 9 38
9767610 1998
10
Identification of an epitope of a recombinant Onchocerca volvulus protein that induces corneal pathology. 9 38
9297706 1997
11
Molecular characterization and expression of Onchocerca volvulus glutathione reductase. 9 38
9271084 1997
12
Immunoregulation in onchocerciasis: persons with ocular inflammatory disease produce a Th2-like response to Onchocerca volvulus antigen. 9 38
8699070 1996
13
Epitopes of the Onchocerca volvulus RAL1 antigen, a member of the calreticulin family of proteins, recognized by sera from patients with onchocerciasis. 9 38
7520419 1994
14
A 16mer peptide of the human autoantigen calreticulin is a most prominent HLA-DR4Dw4-associated self-peptide. 9 38
7836063 1994
15
Serological cross-reactivity between a human Ro/SS-A autoantigen (calreticulin) and the lambda Ral-1 antigen of Onchocerca volvulus. 9 38
1602002 1992
16
Analysis of aqueous humour in ocular onchocerciasis. 9 38
2036808 1991
17
Humoral autoimmune response against S-antigen and IRBP in ocular onchocerciasis. 9 38
2365568 1990
18
A human Ro/SS-A autoantigen is the homologue of calreticulin and is highly homologous with onchocercal RAL-1 antigen and an aplysia "memory molecule". 9 38
2365822 1990
19
Design of novel multi-epitope vaccines against severe acute respiratory syndrome validated through multistage molecular interaction and dynamics. 38
30457455 2019
20
Primary intestinal aspergillosis resulting in acute intestinal volvulus after autologous stem cell transplantation in a patient with relapsed non-Hodgkin lymphoma: report on a rare infectious complication and a review of the literature. 38
30238855 2019
21
Redundant: A case of complicated dolichocolon in a neonate. 38
31360279 2019
22
Transverse Colon Volvulus: a Rare Cause of Intestinal Obstruction. 38
31197687 2019
23
Early Experience with Variant Two-Stage Approach in Surgical Management of Inflammatory Bowel Disease Colitis in the Pediatric Population. 38
31403384 2019
24
Perioperative Outcomes and Predictors of Mortality After Surgery for Sigmoid Volvulus. 38
31415933 2019
25
Prucalopride in Gastroparesis: A Randomized Placebo-Controlled Crossover Study. 38
31295161 2019
26
Concurrent occurrence of a wandering spleen, organoaxial gastric volvulus, pancreatic volvulus, and cholestasis - A rare cause of an acute abdomen. 38
31193859 2019
27
Biology and fungal associates of Xyleborus volvulus (Coleoptera: Curculionidae). 38
31375485 2019
28
Volvulus of sigmoid colon in a challenged adolescent: An unusual case report. 38
31297192 2019
29
Retrospective study on pattern and outcome of management of sigmoid volvulus at district hospital in Ethiopia. 38
31399131 2019
30
A Case of Small Intestinal Ileus Due to Wandering Spleen with a Large Cyst. 38
31371695 2019
31
Comments on 'Sigmoid volvulus and coffee been sign'. 38
31368490 2019
32
Response: "Comments on 'Sigmoid volvulus and coffee been sign'". 38
31368493 2019
33
Surgical Management of an Ileal J-Pouch-Anal Anastomosis Volvulus. 38
31283595 2019
34
Reply to 'comment on colopexy in sigmoid volvulus recurrence'. 38
31435845 2019
35
Preliminary heritability of complete rotation large colon volvulus in Thoroughbred broodmares. 38
31391286 2019
36
Intrauterine volvulus that had been misunderstood as an antenatal mesenteric cyst. 38
30503932 2019
37
Standing Hand-Assisted Laparoscopic Diagnosis and Treatment of a Rare Case of Uterine Adenocarcinoma in an 18-Year-Old Mare. 38
31405498 2019
38
Use of computed tomography volumetric measurements to predict operative techniques in paraesophageal hernia repair. 38
31407111 2019
39
Predicting Morbidity and Mortality in Neonates Born With Gastroschisis. 38
31421366 2019
40
Epidemiological study on intestinal volvulus without malrotation in VLBW infants. 38
30262462 2019
41
Identification and characterization of the Onchocerca volvulus Excretory Secretory Product Ov28CRP, a putative GM2 activator protein. 38
31329585 2019
42
Development and validation of an Onchocerca ochengi adult male worm gerbil model for macrofilaricidal drug screening. 38
31260456 2019
43
Reaching the last mile: main challenges relating to and recommendations to accelerate onchocerciasis elimination in Africa. 38
31269966 2019
44
Onchocerciasis-associated epilepsy in the Democratic Republic of Congo: Clinical description and relationship with microfilarial density. 38
31314757 2019
45
Colectomy for caecal and sigmoid volvulus: a national analysis of outcomes and risk factors for postoperative complications. 38
31260148 2019
46
Secondary pneumatosis cystoides intestinalis complicated by intestinal volvulus: A case report and literature review. 38
30661712 2019
47
Caecal volvulus following left-side laparoscopic retroperitoneal nephroureterectomy. 38
31278197 2019
48
Isolation of an Equine Foamy Virus and Sero-Epidemiology of the Viral Infection in Horses in Japan. 38
31284407 2019
49
Acute chylous peritonitis as a result of jejunal volvulus and small bowel obstruction from a congenital band adhesion. 38
29651811 2019
50
Gastric volvulus involving the duodenum. 38
31352390 2019

Variations for Intestinal Volvulus

Expression for Intestinal Volvulus

Search GEO for disease gene expression data for Intestinal Volvulus.

Pathways for Intestinal Volvulus

GO Terms for Intestinal Volvulus

Cellular components related to Intestinal Volvulus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 EKC/KEOPS complex GO:0000408 8.8 TPRKB TP53RK LAGE3

Biological processes related to Intestinal Volvulus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tRNA processing GO:0008033 8.8 TPRKB TP53RK LAGE3

Molecular functions related to Intestinal Volvulus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.32 TPRKB TP53RK SRCIN1 QRSL1 LHFPL5 LAGE3

Sources for Intestinal Volvulus

3 CDC
7 CNVD
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11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HGMD
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32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
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44 MeSH
45 MESH via Orphanet
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
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73 UMLS via Orphanet
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