MCID: INT019
MIFTS: 30

Intestine Carcinoma in Situ

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Intestine Carcinoma in Situ

MalaCards integrated aliases for Intestine Carcinoma in Situ:

Name: Intestine Carcinoma in Situ 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:9024
ICD10 33 D01.4
ICD9CM 35 230.7
UMLS 73 C0154065

Summaries for Intestine Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the intestine.

MalaCards based summary : Intestine Carcinoma in Situ is related to middle cerebral artery infarction and fibrolamellar carcinoma. An important gene associated with Intestine Carcinoma in Situ is ITGA1 (Integrin Subunit Alpha 1), and among its related pathways/superpathways are Integrin Pathway and Response to elevated platelet cytosolic Ca2+. Affiliated tissues include skin, colon and the intestine, and related phenotypes are cellular and hematopoietic system

Related Diseases for Intestine Carcinoma in Situ

Diseases in the Small Intestine Cancer family:

Large Intestine Cancer Intestine Carcinoma in Situ

Diseases related to Intestine Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 middle cerebral artery infarction 10.1 CD40LG NCAM1
2 fibrolamellar carcinoma 10.1 ITGA1 ITGAV
3 primary thrombocytopenia 10.1 CD40LG ITGA2
4 cd3zeta deficiency 10.1 CD44 NCAM1
5 lethal midline granuloma 10.1 ICAM1 NCAM1
6 congenital epulis 10.1 CD44 ITGA5
7 rheumatoid vasculitis 10.1 CD44 ICAM1
8 pustulosis palmaris et plantaris 10.1 CD40LG SELPLG
9 malignant skin fibrous histiocytoma 10.0 CD99 NCAM1
10 actinic prurigo 10.0 ICAM1 ICAM3
11 burkitt lymphoma 10.0 CD40LG CD44 ICAM1
12 myeloma, multiple 9.9 CD44 ITGA5 NCAM1
13 malignant dermis tumor 9.9 CD99 NCAM1
14 colon carcinoma in situ 8.3 CD40LG CD44 CD99 ICAM1 ICAM2 ICAM3

Graphical network of the top 20 diseases related to Intestine Carcinoma in Situ:



Diseases related to Intestine Carcinoma in Situ

Symptoms & Phenotypes for Intestine Carcinoma in Situ

MGI Mouse Phenotypes related to Intestine Carcinoma in Situ:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 CD40LG CD44 ICAM1 ITGA1 ITGA2 ITGA5
2 hematopoietic system MP:0005397 9.56 CD40LG CD44 ICAM1 ICAM2 ITGA2 ITGAV
3 immune system MP:0005387 9.28 CD40LG CD44 ICAM1 ICAM2 ITGA1 ITGA5

Drugs & Therapeutics for Intestine Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Intestine Carcinoma in Situ

Genetic Tests for Intestine Carcinoma in Situ

Anatomical Context for Intestine Carcinoma in Situ

MalaCards organs/tissues related to Intestine Carcinoma in Situ:

41
Skin, Colon

The Foundational Model of Anatomy Ontology organs/tissues related to Intestine Carcinoma in Situ:

19
The Intestine

Publications for Intestine Carcinoma in Situ

Variations for Intestine Carcinoma in Situ

Expression for Intestine Carcinoma in Situ

Search GEO for disease gene expression data for Intestine Carcinoma in Situ.

Pathways for Intestine Carcinoma in Situ

Pathways related to Intestine Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 CD99 ICAM1 ICAM2 ITGA1 ITGA2 ITGA5
2
Show member pathways
13.14 CD44 CD99 ITGA1 ITGA2 ITGA5 ITGAV
3
Show member pathways
12.83 CD40LG ITGA1 ITGA2 ITGA5 ITGAV
4
Show member pathways
12.74 ITGA1 ITGA2 ITGA5 ITGAV
5
Show member pathways
12.71 ITGA1 ITGA2 ITGA5 ITGAV
6
Show member pathways
12.69 ITGA1 ITGA2 ITGA5 ITGAV
7 12.54 ITGA1 ITGA2 ITGA5 ITGAV
8
Show member pathways
12.53 ITGA1 ITGA2 ITGA5 ITGAV
9 12.48 CD40LG CD44 ICAM2 NCAM1
10
Show member pathways
12.46 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
11
Show member pathways
12.35 ITGA1 ITGA2 ITGA5 ITGAV
12
Show member pathways
12.29 ITGA1 ITGA2 ITGA5 ITGAV
13 12.23 CD44 ITGA2 ITGA5 ITGAV
14
Show member pathways
12.14 ITGA1 ITGA2 ITGA5 ITGAV
15
Show member pathways
12.14 ITGA1 ITGA2 ITGA5 ITGAV
16
Show member pathways
12.08 CD99 ICAM1 ICAM2 ITGA1 ITGA2 ITGA5
17 12.07 ITGA1 ITGA2 ITGA5 ITGAV
18
Show member pathways
12.05 CD44 CD99 ITGA5 ITGAV SELPLG SLC3A2
19 12.04 ITGA2 ITGA5 ITGAV
20
Show member pathways
12.01 ITGA1 ITGA2 ITGA5 ITGAV
21 11.98 CD40LG ICAM1 ICAM2 ICAM3
22 11.9 CD44 ITGA2 ITGAV NCAM1
23 11.88 ITGA1 ITGA2 ITGA5 ITGAV
24
Show member pathways
11.86 ITGA1 ITGA2 ITGA5 ITGAV NCAM1
25 11.82 CD44 ICAM1 ICAM2 ITGA5 ITGAV NCAM1
26 11.78 CD44 ITGA1 ITGA2 ITGA5
27
Show member pathways
11.73 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
28 11.71 ITGA1 ITGA2 ITGA5 ITGAV
29 11.65 ITGA1 ITGA2 ITGA5 ITGAV
30 11.6 CD44 ITGA1 ITGA5
31 11.57 ITGA1 ITGA2 ITGA5 ITGAV
32 11.56 ITGA2 ITGAV NCAM1
33 11.46 ITGA1 ITGA2 ITGA5 ITGAV
34 11.46 ICAM1 ICAM2 SELPLG
35 11.41 ICAM1 ICAM2 ICAM3
36 11.38 CD40LG CD99 ICAM1 ICAM2 ICAM3 ITGAV
37 11.34 ITGA1 ITGA2 ITGA5 ITGAV
38 11.31 ITGA1 ITGA2 ITGA5 ITGAV
39 11.3 CD44 ITGA2 ITGA5
40 11.29 CD44 NCAM1
41 11.21 ITGA2 ITGA5
42 11.06 ITGA1 ITGA2 ITGA5
43 11.02 ICAM2 ICAM3
44 11.01 ITGA5 ITGAV NCAM1
45 10.94 CD40LG ITGA1 ITGA2 ITGA5 ITGAV
46 10.78 ITGA1 ITGA2

GO Terms for Intestine Carcinoma in Situ

Cellular components related to Intestine Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 9.7 CD44 CD99 ICAM1 ITGA1 ITGA2 ITGA5
2 integrin complex GO:0008305 9.56 ITGA1 ITGA2 ITGA5 ITGAV
3 external side of plasma membrane GO:0009897 9.5 CD40LG ICAM1 ITGA1 ITGA2 ITGA5 ITGAV
4 lamellipodium membrane GO:0031258 9.49 CD44 ITGAV
5 basal part of cell GO:0045178 9.48 ITGA1 ITGA2
6 uropod GO:0001931 9.46 ICAM2 SELPLG
7 cell surface GO:0009986 9.28 CD40LG CD44 ICAM1 ITGA1 ITGA2 ITGA5
8 membrane GO:0016020 10.25 CD40LG CD44 CD99 ICAM1 ICAM2 ICAM3
9 integral component of membrane GO:0016021 10.18 CD40LG CD44 CD99 ICAM1 ICAM2 ICAM3
10 plasma membrane GO:0005886 10.13 CD40LG CD44 CD99 ICAM1 ICAM2 ICAM3
11 integral component of plasma membrane GO:0005887 10.01 CD40LG CD44 CD99 ICAM1 ICAM2 ICAM3

Biological processes related to Intestine Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.85 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG
2 cell-cell adhesion GO:0098609 9.81 CD44 ICAM1 ICAM2 ICAM3
3 regulation of immune response GO:0050776 9.8 CD40LG CD99 ICAM1 ICAM2 ICAM3
4 leukocyte migration GO:0050900 9.8 CD44 ICAM1 ITGA5 ITGAV SELPLG SLC3A2
5 cell-matrix adhesion GO:0007160 9.78 CD44 ITGA1 ITGA2 ITGAV
6 integrin-mediated signaling pathway GO:0007229 9.76 ITGA1 ITGA2 ITGA5 ITGAV
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.71 CD44 ICAM1 ITGA5
8 interferon-gamma-mediated signaling pathway GO:0060333 9.7 CD44 ICAM1 NCAM1
9 leukocyte cell-cell adhesion GO:0007159 9.67 CD40LG ICAM1 ITGA5
10 viral entry into host cell GO:0046718 9.63 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG
11 cell-substrate adhesion GO:0031589 9.61 ITGA2 ITGA5 ITGAV
12 endodermal cell differentiation GO:0035987 9.57 ITGA5 ITGAV
13 heterotypic cell-cell adhesion GO:0034113 9.56 ITGA5 ITGAV
14 cell adhesion mediated by integrin GO:0033627 9.56 ICAM1 ITGA2 ITGA5 ITGAV
15 extracellular matrix organization GO:0030198 9.56 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
16 cellular response to interleukin-6 GO:0071354 9.55 ICAM1 SELPLG
17 cell adhesion GO:0007155 9.36 CD44 CD99 ICAM1 ICAM2 ICAM3 ITGA1

Molecular functions related to Intestine Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.62 ICAM3 ITGA1 ITGAV SELPLG
2 collagen binding GO:0005518 9.43 CD44 ITGA1 ITGA2
3 integrin binding GO:0005178 9.43 ICAM1 ICAM2 ICAM3 ITGA2 ITGA5 ITGAV
4 collagen binding involved in cell-matrix adhesion GO:0098639 9.16 ITGA1 ITGA2
5 virus receptor activity GO:0001618 9.1 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG

Sources for Intestine Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....