MCID: INT019
MIFTS: 30

Intestine Carcinoma in Situ

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Intestine Carcinoma in Situ

MalaCards integrated aliases for Intestine Carcinoma in Situ:

Name: Intestine Carcinoma in Situ 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:9024
ICD9CM 36 230.7
ICD10 34 D01.4
UMLS 74 C0154065

Summaries for Intestine Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the intestine.

MalaCards based summary : Intestine Carcinoma in Situ is related to middle cerebral artery infarction and cd3zeta deficiency. An important gene associated with Intestine Carcinoma in Situ is ITGA1 (Integrin Subunit Alpha 1), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include the intestine, and related phenotypes are Reduced mammosphere formation and cellular

Related Diseases for Intestine Carcinoma in Situ

Graphical network of the top 20 diseases related to Intestine Carcinoma in Situ:



Diseases related to Intestine Carcinoma in Situ

Symptoms & Phenotypes for Intestine Carcinoma in Situ

GenomeRNAi Phenotypes related to Intestine Carcinoma in Situ according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CD28 CD44 ICAM2 ITGA2 NCAM1 SELPLG

MGI Mouse Phenotypes related to Intestine Carcinoma in Situ:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.17 CD28 CD40LG CD44 ICAM1 ITGA1 ITGA2
2 hematopoietic system MP:0005397 10.02 CD28 CD40LG CD44 CTLA4 ICAM1 ICAM2
3 homeostasis/metabolism MP:0005376 9.96 CD28 CD40LG CD44 CTLA4 ICAM1 ITGA1
4 endocrine/exocrine gland MP:0005379 9.91 CD28 CD40LG CD44 CTLA4 ICAM1 ITGA2
5 immune system MP:0005387 9.9 CD28 CD40LG CD44 CTLA4 ICAM1 ICAM2
6 digestive/alimentary MP:0005381 9.88 CD28 CD44 CTLA4 ICAM1 ITGAV SLC3A2
7 integument MP:0010771 9.5 CD28 CD40LG CD44 CTLA4 ICAM1 ITGA2
8 mortality/aging MP:0010768 9.32 CD40LG CD44 CTLA4 ICAM1 ITGA1 ITGA5

Drugs & Therapeutics for Intestine Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Intestine Carcinoma in Situ

Genetic Tests for Intestine Carcinoma in Situ

Anatomical Context for Intestine Carcinoma in Situ

The Foundational Model of Anatomy Ontology organs/tissues related to Intestine Carcinoma in Situ:

20
The Intestine

Publications for Intestine Carcinoma in Situ

Variations for Intestine Carcinoma in Situ

Expression for Intestine Carcinoma in Situ

Search GEO for disease gene expression data for Intestine Carcinoma in Situ.

Pathways for Intestine Carcinoma in Situ

Pathways related to Intestine Carcinoma in Situ according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 CD28 CD40LG CD44 CTLA4 ICAM1 ICAM2
2
Show member pathways
13.37 CD28 CD40LG CTLA4 ICAM1 ICAM2 ICAM3
3
Show member pathways
13.33 CD99 ICAM1 ICAM2 ITGA1 ITGA2 ITGA5
4
Show member pathways
13.32 CD28 CD40LG ITGA1 ITGA2 ITGA5 ITGAV
5
Show member pathways
13.17 CD44 CD99 ITGA1 ITGA2 ITGA5 ITGAV
6
Show member pathways
12.84 CD40LG ITGA1 ITGA2 ITGA5 ITGAV
7
Show member pathways
12.72 ITGA1 ITGA2 ITGA5 ITGAV
8
Show member pathways
12.71 ITGA1 ITGA2 ITGA5 ITGAV
9 12.55 ITGA1 ITGA2 ITGA5 ITGAV
10
Show member pathways
12.54 ITGA1 ITGA2 ITGA5 ITGAV
11 12.47 CD28 CD40LG CD44 CTLA4 ICAM2 NCAM1
12
Show member pathways
12.46 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
13
Show member pathways
12.37 ITGA1 ITGA2 ITGA5 ITGAV
14
Show member pathways
12.3 ITGA1 ITGA2 ITGA5 ITGAV
15 12.23 CD44 ITGA2 ITGA5 ITGAV
16
Show member pathways
12.15 ITGA1 ITGA2 ITGA5 ITGAV
17
Show member pathways
12.15 ITGA1 ITGA2 ITGA5 ITGAV
18
Show member pathways
12.1 CD99 ICAM1 ICAM2 ITGA1 ITGA2 ITGA5
19 12.07 ITGA1 ITGA2 ITGA5 ITGAV
20 12.05 ITGA2 ITGA5 ITGAV
21
Show member pathways
12.05 CD44 CD99 ITGA5 ITGAV SELPLG SLC3A2
22
Show member pathways
12.02 ITGA1 ITGA2 ITGA5 ITGAV
23 11.99 CD40LG ICAM1 ICAM2 ICAM3
24
Show member pathways
11.9 ITGA1 ITGA2 ITGA5 ITGAV NCAM1
25 11.89 ITGA1 ITGA2 ITGA5 ITGAV
26 11.83 CD28 CD44 ITGA2 ITGAV NCAM1
27 11.82 CD44 ITGA1 ITGA2 ITGA5
28 11.82 CD44 ICAM1 ICAM2 ITGA5 ITGAV NCAM1
29 11.81 CD28 CTLA4 ICAM1
30 11.74 ITGA1 ITGA2 ITGA5 ITGAV
31
Show member pathways
11.73 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
32
Show member pathways
11.71 CD40LG CTLA4 SLC3A2
33 11.67 ITGA1 ITGA2 ITGA5 ITGAV
34 11.6 CD44 ITGA1 ITGA5
35 11.58 CD28 CD40LG CTLA4
36 11.57 ITGA1 ITGA2 ITGA5 ITGAV
37 11.56 ITGA2 ITGAV NCAM1
38 11.48 CD28 CD40LG CD99 CTLA4 ICAM1 ICAM2
39 11.47 ITGA1 ITGA2 ITGA5 ITGAV
40 11.47 ICAM1 ICAM2 SELPLG
41 11.42 ICAM1 ICAM2 ICAM3
42 11.35 ITGA1 ITGA2 ITGA5 ITGAV
43 11.34 ITGA1 ITGA2 ITGA5 ITGAV
44 11.31 CD44 ITGA2 ITGA5
45 11.23 CD28 CD40LG
46 11.23 ITGA2 ITGA5
47 11.2 CD28 CTLA4
48 11.09 ITGA1 ITGA2 ITGA5
49 11.03 ICAM2 ICAM3
50 11.02 ITGA5 ITGAV NCAM1

GO Terms for Intestine Carcinoma in Situ

Cellular components related to Intestine Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 9.91 CD44 CD99 ICAM1 ITGA1 ITGA2 ITGA5
2 integrin complex GO:0008305 9.71 ITGA1 ITGA2 ITGA5 ITGAV
3 cell surface GO:0009986 9.65 CD28 CD40LG CD44 ICAM1 ITGA1 ITGA2
4 lamellipodium membrane GO:0031258 9.51 CD44 ITGAV
5 basal part of cell GO:0045178 9.49 ITGA1 ITGA2
6 uropod GO:0001931 9.48 ICAM2 SELPLG
7 protein complex involved in cell adhesion GO:0098636 9.46 CD28 CTLA4
8 external side of plasma membrane GO:0009897 9.28 CD28 CD40LG CTLA4 ICAM1 ITGA1 ITGA2
9 membrane GO:0016020 10.31 CD28 CD40LG CD44 CD99 CTLA4 ICAM1
10 integral component of membrane GO:0016021 10.13 CD28 CD40LG CD44 CD99 CTLA4 ICAM1
11 plasma membrane GO:0005886 10.03 CD28 CD40LG CD44 CD99 CTLA4 ICAM1
12 integral component of plasma membrane GO:0005887 10.02 CD28 CD40LG CD44 CD99 CTLA4 ICAM1

Biological processes related to Intestine Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.85 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG
2 cell-cell adhesion GO:0098609 9.81 CD44 ICAM1 ICAM2 ICAM3
3 regulation of immune response GO:0050776 9.8 CD40LG CD99 ICAM1 ICAM2 ICAM3
4 leukocyte migration GO:0050900 9.8 CD44 ICAM1 ITGA5 ITGAV SELPLG SLC3A2
5 cell-matrix adhesion GO:0007160 9.78 CD44 ITGA1 ITGA2 ITGAV
6 integrin-mediated signaling pathway GO:0007229 9.76 ITGA1 ITGA2 ITGA5 ITGAV
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.72 CD44 ICAM1 ITGA5
8 interferon-gamma-mediated signaling pathway GO:0060333 9.71 CD44 ICAM1 NCAM1
9 T cell costimulation GO:0031295 9.7 CD28 CD40LG CTLA4
10 leukocyte cell-cell adhesion GO:0007159 9.67 CD40LG ICAM1 ITGA5
11 viral entry into host cell GO:0046718 9.63 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG
12 cell-substrate adhesion GO:0031589 9.61 ITGA2 ITGA5 ITGAV
13 endodermal cell differentiation GO:0035987 9.6 ITGA5 ITGAV
14 heterotypic cell-cell adhesion GO:0034113 9.59 ITGA5 ITGAV
15 positive regulation of interleukin-10 production GO:0032733 9.58 CD28 CD40LG
16 positive regulation of interleukin-4 production GO:0032753 9.58 CD28 CD40LG
17 cellular response to interleukin-6 GO:0071354 9.57 ICAM1 SELPLG
18 regulation of regulatory T cell differentiation GO:0045589 9.56 CD28 CTLA4
19 cell adhesion mediated by integrin GO:0033627 9.56 ICAM1 ITGA2 ITGA5 ITGAV
20 extracellular matrix organization GO:0030198 9.56 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
21 cell adhesion GO:0007155 9.36 CD44 CD99 ICAM1 ICAM2 ICAM3 ITGA1

Molecular functions related to Intestine Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.62 ICAM3 ITGA1 ITGAV SELPLG
2 collagen binding GO:0005518 9.43 CD44 ITGA1 ITGA2
3 integrin binding GO:0005178 9.43 ICAM1 ICAM2 ICAM3 ITGA2 ITGA5 ITGAV
4 collagen binding involved in cell-matrix adhesion GO:0098639 9.16 ITGA1 ITGA2
5 virus receptor activity GO:0001618 9.1 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG
6 protein binding GO:0005515 10.18 CD28 CD40LG CD44 CD99 CTLA4 ICAM1

Sources for Intestine Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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