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MCID: INT073
MIFTS: 25

Intracortical Osteogenic Sarcoma

Categories: Bone diseases, Cancer diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Intracortical Osteogenic Sarcoma

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MalaCards integrated aliases for Intracortical Osteogenic Sarcoma:

Name: Intracortical Osteogenic Sarcoma 12 15
Intracortical Osteosarcoma 12 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7602
NCIt 49 C35870
UMLS 71 C1266166
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Summaries for Intracortical Osteogenic Sarcoma

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MalaCards based summary : Intracortical Osteogenic Sarcoma, also known as intracortical osteosarcoma, is related to childhood intracortical osteosarcoma and conventional central osteosarcoma, and has symptoms including pain An important gene associated with Intracortical Osteogenic Sarcoma is ENC1 (Ectodermal-Neural Cortex 1), and among its related pathways/superpathways are Neural Crest Differentiation and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include bone, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and cardiovascular system

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Related Diseases for Intracortical Osteogenic Sarcoma

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Diseases related to Intracortical Osteogenic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 childhood intracortical osteosarcoma 12.5
2 conventional central osteosarcoma 11.8
3 osteogenic sarcoma 10.1
4 sarcoma 10.1
5 spindle cell sarcoma 10.1
6 fibrous dysplasia 10.0
7 periosteal osteogenic sarcoma 10.0
8 intrahepatic gall duct cancer 9.9 PTPRC EPCAM
9 lymph node disease 9.9 PTPRC EPCAM
10 spastic paraplegia 3, autosomal dominant 9.9 PTPRC CDH2
11 hypoplastic left heart syndrome 9.9 LEP CDH2
12 adrenal cortex disease 9.7 PTH LEP
13 pseudohypoparathyroidism 9.7 PTH LEP
14 short bowel syndrome 9.7 PTH LEP
15 bone resorption disease 9.6 PTH LEP
16 bone remodeling disease 9.6 PTH LEP
17 leptin deficiency or dysfunction 9.6 PTH LEP
18 hyperuricemia 9.5 PTH LEP
19 brittle bone disorder 9.4 PTPRC PTH
20 uremia 9.4 PTH LEP
21 hyperthyroidism 9.2 PTH LEP
22 diabetes mellitus, insulin-dependent 9.2 PTPRC PTH LEP
23 muscular disease 9.2 PTPRC PTH LEP

Graphical network of the top 20 diseases related to Intracortical Osteogenic Sarcoma:



Diseases related to Intracortical Osteogenic Sarcoma
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Symptoms & Phenotypes for Intracortical Osteogenic Sarcoma

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UMLS symptoms related to Intracortical Osteogenic Sarcoma:


pain

GenomeRNAi Phenotypes related to Intracortical Osteogenic Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 8.8 CDH2 EPCAM PTPRC

MGI Mouse Phenotypes related to Intracortical Osteogenic Sarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 CDH2 EPCAM HDAC8 LEP PTH PTPRC
2 cellular MP:0005384 9.43 CDH2 EPCAM HDAC8 LEP PTH PTPRC
3 growth/size/body region MP:0005378 9.17 CDH2 ENC1 EPCAM HDAC8 LEP PTH
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Drugs & Therapeutics for Intracortical Osteogenic Sarcoma

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Search Clinical Trials , NIH Clinical Center for Intracortical Osteogenic Sarcoma

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Genetic Tests for Intracortical Osteogenic Sarcoma

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Anatomical Context for Intracortical Osteogenic Sarcoma

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MalaCards organs/tissues related to Intracortical Osteogenic Sarcoma:

40
Bone
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Publications for Intracortical Osteogenic Sarcoma

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Articles related to Intracortical Osteogenic Sarcoma:

(show all 16)
# Title Authors PMID Year
1
Intracortical osteosarcoma of the tibia in a 14-year-old girl. 61
21304410 2011
2
Intracortical osteosarcoma; two-year delay in diagnosis. 61
12324829 2002
3
Intracortical osteosarcoma: is MRI useful? 61
11588687 2001
4
Intracortical osteosarcoma: report of a case. 61
11000737 2000
5
Intracortical osteoblastic osteosarcoma with oncogenic rickets. 61
10068074 1999
6
Intracortical osteosarcoma. 61
9592909 1998
7
Unusual evolution of a benign-looking cortical defect of the proximal humerus. A case of intracortical osteosarcoma? 61
9586258 1998
8
Intracortical low grade osteosarcoma. A unique case and review of the literature on intracortical osteosarcoma. 61
8705794 1996
9
Intracortical small cell osteosarcoma. 61
1600666 1992
10
Intracortical osteosarcoma. A case report. 61
2060212 1991
11
Case report 700: Primary intracortical osteosarcoma of femur, sclerosing variant, grade 1 to 2 anaplasia. 61
1776030 1991
12
Case report 585: Intracortical osteosarcoma of tibia. 61
2692187 1989
13
Intracortical osteosarcoma. 61
6582789 1984
14
Intracortical osteosarcoma: rare entity or early manifestation of classical osteosarcoma? 61
6575445 1983
15
Intracortical osteosarcoma. 61
7002283 1980
16
Intracortical osteogenic sarcoma. 61
13789156 1960
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Variations for Intracortical Osteogenic Sarcoma

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Expression for Intracortical Osteogenic Sarcoma

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Search GEO for disease gene expression data for Intracortical Osteogenic Sarcoma.
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Pathways for Intracortical Osteogenic Sarcoma

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Pathways related to Intracortical Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neural Crest Differentiation 1
11.27 HDAC8 CDH2
2
Dendritic Cells Developmental Lineage Pathway 64
11.02 PTPRC EPCAM
3
Signaling events mediated by PTP1B 1
10.65 LEP CDH2
4
Jak/STAT Signaling Pathway Intracellular Regulation 64
10.23 PTPRC HDAC8
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GO Terms for Intracortical Osteogenic Sarcoma

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Biological processes related to Intracortical Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 9.37 PTPRC LEP
2 response to nutrient levels GO:0031667 9.32 PTH LEP
3 positive regulation of tumor necrosis factor production GO:0032760 9.26 PTPRC LEP
4 T cell differentiation GO:0030217 9.16 PTPRC LEP
5 positive regulation of stem cell proliferation GO:2000648 8.96 PTPRC EPCAM
6 positive regulation of MAPK cascade GO:0043410 8.8 PTPRC LEP CDH2

Molecular functions related to Intracortical Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.62 PTH LEP
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Sources for Intracortical Osteogenic Sarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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