MCID: INT030
MIFTS: 60

Intracranial Aneurysm

Categories: Blood diseases, Cardiovascular diseases, Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Intracranial Aneurysm

MalaCards integrated aliases for Intracranial Aneurysm:

Name: Intracranial Aneurysm 12 56 45 15 74
Brain Aneurysm 12 55 56 6 44 17 74
Cerebral Arterial Aneurysm 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10941
MeSH 45 D002532
NCIt 51 C34458
SNOMED-CT 69 42994005

Summaries for Intracranial Aneurysm

NINDS : 55 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.  A cerebral aneurysm can press on a nerve or surrounding tissue in the brain, and also leak or burst, which lets blood spill into surrounding tissues (called a hemorrhage). Cerebral aneurysms can occur at any age, although they are more common in adults than in children and are more common in women than in men. These aneurysms can occur anywhere in the brain. Some small aneurysms may not show signs and are usually detected during imaging tests for other medical conditions. The signs and symptoms of an unruptured cerebral aneurysm will partly depend on its size and rate of growth. A larger aneurysm that is steadily growing may produce symptoms such as numbness, pain above and behind the eye, and paralysis on one side of the face. Immediately after an aneurysm ruptures, an individual may experience such symptoms as a sudden and unusually severe headache, nausea, vision impairment, vomiting, and loss of consciousness.

MalaCards based summary : Intracranial Aneurysm, also known as brain aneurysm, is related to cerebral aneurysms and arteriovenous malformations of the brain, and has symptoms including seizures, tremor and angina pectoris. An important gene associated with Intracranial Aneurysm is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Propofol and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related phenotypes are cardiovascular system and homeostasis/metabolism

MedlinePlus : 44 A brain aneurysm is an abnormal bulge or "ballooning" in the wall of an artery in the brain. They are sometimes called berry aneurysms because they are often the size of a small berry. Most brain aneurysms produce no symptoms until they become large, begin to leak blood, or burst. If a brain aneurysm presses on nerves in your brain, it can cause signs and symptoms. These can include A droopy eyelid Double vision or other changes in vision Pain above or behind the eye A dilated pupil Numbness or weakness on one side of the face or body Treatment depends on the size and location of the aneurysm, whether it is infected, and whether it has burst. If a brain aneurysm bursts, symptoms can include a sudden, severe headache, nausea and vomiting, stiff neck, loss of consciousness, and signs of a stroke. Any of these symptoms requires immediate medical attention. NIH: National Heart, Lung, and Blood Institute

Wikipedia : 77 Intracranial aneurysm, also known as brain aneurysm, is a cerebrovascular disorder in which weakness in... more...

Related Diseases for Intracranial Aneurysm

Diseases in the Intracranial Aneurysm family:

Intracranial Aneurysms Multiple Congenital Anomaly

Diseases related to Intracranial Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
# Related Disease Score Top Affiliating Genes
1 cerebral aneurysms 30.7 ELN MMP2
2 arteriovenous malformations of the brain 30.3 CDKN2B-AS1 ENG SOX17
3 aortic aneurysm, familial abdominal, 1 30.2 CDKN2B-AS1 ELN MMP2
4 aortic aneurysm 29.7 CDKN2B-AS1 COL3A1 ELN FBN2 LOX
5 connective tissue disease 29.7 COL1A2 COL3A1 ELN FBN2
6 supravalvular aortic stenosis 29.6 ELN LIMK1
7 marfan syndrome 29.5 COL1A2 COL3A1 ELN FBN2 MMP2
8 intracranial aneurysms multiple congenital anomaly 12.2
9 fibromuscular dysplasia 11.5
10 polycystic kidney disease 1 with or without polycystic liver disease 11.4
11 intracranial berry aneurysm 11.3
12 aneurysm, intracranial berry, 1 11.1
13 aneurysm, intracranial berry, 5 11.1
14 aneurysm, intracranial berry, 3 11.1
15 aneurysm, intracranial berry, 4 11.1
16 aneurysm, intracranial berry, 6 11.1
17 aneurysm, intracranial berry, 7 11.1
18 aneurysm, intracranial berry, 8 11.1
19 aneurysm, intracranial berry, 9 11.1
20 aneurysm, intracranial berry, 10 11.1
21 immunodeficiency 31c 11.1
22 aneurysm, intracranial berry, 11 11.1
23 loeys-dietz syndrome 4 11.1
24 abducens nerve disease 11.0
25 internal carotid agenesis 11.0
26 polycystic kidney disease 10.5
27 kidney disease 10.5
28 autosomal dominant polycystic kidney disease 10.5
29 thrombosis 10.4
30 arteriovenous malformation 10.4
31 carotid stenosis 10.4
32 familial cerebral saccular aneurysm 10.3 COL3A1 ENG
33 familial abdominal aortic aneurysm 10.3 COL3A1 ELN
34 ehlers-danlos syndrome, vascular type 10.3 COL3A1 ELN
35 larsen-like syndrome 10.3 COL1A2 COL3A1
36 cutis laxa, autosomal recessive, type ib 10.3 ELN LOX
37 moyamoya disease 1 10.3
38 heritable pulmonary arterial hypertension 10.3 ENG SOX17
39 lipoblastoma 10.2 COL1A2 COL3A1
40 senile ectropion 10.2 ELN MMP2
41 headache 10.2
42 phacogenic glaucoma 10.2 ELN LOX
43 endocarditis 10.2
44 aortic coarctation 10.2
45 ehlers-danlos syndrome, classic type, 1 10.2 COL1A2 COL3A1
46 autosomal recessive cutis laxa type i 10.2 ELN LOX
47 tuberous sclerosis 10.2
48 tetralogy of fallot 10.1
49 stroke, ischemic 10.1
50 hydrocephalus 10.1

Graphical network of the top 20 diseases related to Intracranial Aneurysm:



Diseases related to Intracranial Aneurysm

Symptoms & Phenotypes for Intracranial Aneurysm

UMLS symptoms related to Intracranial Aneurysm:


seizures, tremor, angina pectoris, edema, back pain, pain, chest pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Intracranial Aneurysm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.22 ACE2 COL1A2 COL3A1 ENG FBN2 LOX
2 homeostasis/metabolism MP:0005376 10.18 ACE2 CDKN2B COL1A2 COL3A1 ENG FBN2
3 cellular MP:0005384 10.11 ACE2 CDKN2B COL1A2 COL3A1 FBN2 LIMK1
4 growth/size/body region MP:0005378 10.1 ACE2 COL1A2 COL3A1 ENG FBN2 MMP2
5 mortality/aging MP:0010768 10.03 ACE2 CDKN2B COL1A2 COL3A1 ENG FBN2
6 digestive/alimentary MP:0005381 9.91 ACE2 COL3A1 ENG NOS3 PKD1 SOX17
7 integument MP:0010771 9.87 ACE2 CDKN2B COL1A2 COL3A1 ENG LOX
8 muscle MP:0005369 9.85 ACE2 COL1A2 COL3A1 ENG FBN2 LOX
9 normal MP:0002873 9.5 COL1A2 ENG MMP2 NOS3 PKD1 SOX17
10 respiratory system MP:0005388 9.23 ACE2 COL3A1 ENG FBN2 LOX MMP2

Drugs & Therapeutics for Intracranial Aneurysm

Drugs for Intracranial Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 171)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
2
Benzocaine Approved, Investigational Phase 4,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
3
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Not Applicable 28523-86-6 5206
4
tannic acid Approved Phase 4,Not Applicable,Early Phase 1 1401-55-4
5
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 113775-47-6 68602 5311068
6
Desflurane Approved Phase 4 57041-67-5 42113
7
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
8
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
9
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
10
Levetiracetam Approved, Investigational Phase 4 102767-28-2 441341
11 Anesthetics Phase 4,Phase 3,Not Applicable
12 Anesthetics, Inhalation Phase 4,Phase 3,Not Applicable
13 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable
14 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Anesthetics, General Phase 4,Phase 3,Not Applicable
16 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
19 Protective Agents Phase 4,Phase 2,Phase 3
20 Neuroprotective Agents Phase 4,Phase 2,Phase 3
21 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Nootropic Agents Phase 4,Phase 2,Phase 3
23 Anticonvulsants Phase 4,Phase 2,Not Applicable
24 Anesthetics, Intravenous Phase 4,Phase 3,Not Applicable
25 Hypnotics and Sedatives Phase 4,Phase 3,Not Applicable
26 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Adrenergic Agents Phase 4,Phase 3,Not Applicable
28 Adrenergic alpha-Agonists Phase 4,Phase 3,Not Applicable
29 Adrenergic Agonists Phase 4,Phase 3,Not Applicable
30 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3,Not Applicable
31 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Respiratory System Agents Phase 4
33 Bronchodilator Agents Phase 4
34 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Vasodilator Agents Phase 4,Phase 1,Phase 2
36 Anti-Asthmatic Agents Phase 4
37 Autonomic Agents Phase 4
38 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
39 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
40 Antipyretics Phase 4,Phase 3,Phase 2,Phase 1
41 Phosphodiesterase Inhibitors Phase 4,Phase 2
42 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3
43 Purinergic P2 Receptor Antagonists Phase 4,Phase 3
44 Phosphodiesterase 3 Inhibitors Phase 4
45 Prasugrel hydrochloride Phase 4 389574-19-0
46
Simvastatin Approved Phase 3 79902-63-9 54454
47
Esmolol Approved Phase 3 103598-03-4, 81147-92-4 59768
48
Ticagrelor Approved Phase 3 274693-27-5 9871419
49
Calcium Approved, Nutraceutical Phase 2, Phase 3,Phase 1,Not Applicable 7440-70-2 271
50
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3 50-14-6 5280793

Interventional clinical trials:

(show top 50) (show all 253)
# Name Status NCT ID Phase Drugs
1 Treatment of Cranial Internal Carotid Artery Aneurysm With Willis Covered Stent and Coil Embolization Unknown status NCT01029938 Phase 4
2 Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions Unknown status NCT02478346 Phase 4 Fluorescein Sodium
3 Delayed Vasospasm After Aneurysm With the Standardization Treatment of Traditional Chinese Medicine Unknown status NCT01840761 Phase 4 herbal drug;placebo
4 Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function Completed NCT02691416 Phase 4 propofol postconditioning;sevoflurane
5 PRET: Patients Prone to Recurrence After Endovascular Treatment Completed NCT00626912 Phase 4
6 A Better Choice for Patients Undergoing Endovascular Coil Embolization Completed NCT01722409 Phase 4 sevoflurane and 0.5 μg/kg dexmedetomidine;sevoflurane and 1 μg/kg dexmedetomidine
7 MAPS Trial: Matrix And Platinum Science Completed NCT00396981 Phase 4
8 Aneurysm Wall Histology Registry Completed NCT01444664 Phase 4
9 Study of the Penumbra Coil 400 System to Treat Aneurysm Completed NCT01465841 Phase 4
10 Comparison of Neuroprotection by Propofol and Desflurane for POCD Following Subarachnoid Hemorrhage Surgery Completed NCT02987218 Phase 4 Propofol;Desflurane
11 Flow Diversion in Intracranial Aneurysm Treatment Recruiting NCT01349582 Phase 4
12 Stenting in the Treatment of Aneurysm Trial Recruiting NCT01340612 Phase 4
13 Comparison of Two Different Antiplatelet Preparations for an Unruptured Intracranial Aneurysm Recruiting NCT03581409 Phase 4 Aspirin;Prasugrel;Clopidogrel;Cilostazol
14 Seizure Prophylaxis in Aneurysm Repair Recruiting NCT01801072 Phase 4 Levetiracetam
15 HYdrogel Coil Versus Bare Platinum Coil in Recanalization Imaging Data Study Active, not recruiting NCT01516658 Phase 4
16 Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil Active, not recruiting NCT02729740 Phase 4
17 Study of Antiplatelet Therapy for Intracranial Aneurysm Stent-assisted Coiling Not yet recruiting NCT02224131 Phase 4 Aspirin and clopidogrel;Aspirin and clopidogrel
18 Seizure Prophylaxis in Aneurysm Repair Terminated NCT01974700 Phase 4 Levetiracetam
19 LARGE Aneurysm Randomized Trial: Flow Diversion Versus Traditional Endovascular Coiling Therapy Terminated NCT01762137 Phase 4
20 HydroCoil Cerebral Aneurysm Treatment Trial Terminated NCT01195129 Phase 4
21 Hydrogel Balloon Assisted Intracranial Aneurysm Coiling Registry Withdrawn NCT02037932 Phase 4
22 Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety and Efficacy of Cerebrolysin™ in Patients With Aneurysmal Subarachnoid Hemorrhage Unknown status NCT01787123 Phase 2, Phase 3 Intravenous Cerebrolysin
23 Feasibility Study of the LVIS™ (Low-profile Visualized Intraluminal Support)Device Completed NCT01541254 Phase 2, Phase 3
24 Complete Occlusion of Coilable Aneurysms Completed NCT00777907 Phase 3
25 Hypothermia During Intracranial Aneurysm Surgery Trial Completed NCT00029133 Phase 3
26 Simvastatin in Aneurysmal Subarachnoid Haemorrhage (STASH) a Multicentre Randomised Controlled Clinical Trial Completed NCT00731627 Phase 3 placebo;simvastatin
27 Esmolol Infusion in Patients Undergoing Craniotomy Completed NCT02455440 Phase 3 Esmolol;Placebo;Propofol and sevoflurane
28 A Study Evaluating the Safety and Effectiveness of the PulseRider® Aneurysm Neck Reconstruction Device Used in Conjunction With Endovascular Coil Embolization in the Treatment of Wide-Neck Bifurcation Intracranial Aneurysm Recruiting NCT03383666 Phase 3
29 Acetylsalicylic Acid Plus Intensive Blood Pressure Treatment in Patients With Unruptured Intracranial Aneurysms Recruiting NCT03063541 Phase 3 Acetylsalicylic acid
30 Ticagrelor vs Clopidogrel for Platelet Inhibition in Stenting for Cerebral Aneurysm Recruiting NCT02675205 Phase 3 Clopidogrel;Ticagrelor;aspirin
31 Esmolol Versus Dexmedetomidine During Intracranial Procedures Recruiting NCT02563288 Phase 3 Esmolol;Dexmedetomidine
32 The Neuroprotective Effect of Remote Ischemic Conditioning in Ruptured Aneurysm Coiling Therapy Recruiting NCT03561311 Phase 2, Phase 3
33 The Neuroprotective Effect of Remote Ischemic Conditioning in Aneurysm Coiling Therapy Recruiting NCT03496415 Phase 2, Phase 3
34 Intraventricular Fibrinolysis for Aneurysmal Subarachnoid Hemorrhage. Recruiting NCT03187405 Phase 3 EVD + IVF with Alteplase
35 Hypovitaminosis D in Neurocritical Patients Active, not recruiting NCT02881957 Phase 2, Phase 3 Cholecalciferol
36 Safety and Performance of the Penumbra Liberty Stent in the Treatment of Wide-Neck, Saccular, Intracranial Aneurysms Unknown status NCT01753388 Phase 2
37 Intraventricular Tissue Plasminogen Activator (tPA) in the Management of Aneurysmal Subarachnoid Hemorrhage Unknown status NCT01098890 Phase 2 Tissue Plasminogen Activator;Placebo
38 Clevidipine for Vasospasm After Subarachnoid Hemorrhage (SAH) Unknown status NCT02011321 Phase 2 clevidipine
39 Safety and Efficacy Study of Clevidipine to Control Hypertension in Patients Admitted With Aneurysmal Subarachnoid Hemorrhage Unknown status NCT00978822 Phase 2 Clevidipine butyrate injectable emulsion
40 Safety and Tolerability Study of EG-1962 in Aneurysmal Subarachnoid Hemorrhage Completed NCT01893190 Phase 1, Phase 2 Nimodipine;Nimodipine Microparticles
41 Evaluating Neuroprotection in Aneurysm Coiling Therapy Completed NCT00728182 Phase 2 NA-1;Placebo
42 Evaluation of the Efficacy and Safety of Clazosentan in Reversing Cerebral Vasospasm in Adult Subjects With Aneurysmal Subarachnoid Hemorrhage Completed NCT02560532 Phase 2 Clazosentan
43 Estrogen Therapy as Prevention in the Progression of Aneurysm (EPPA) Trial Recruiting NCT01895881 Phase 2 Estradiol;Placebo
44 Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin Recruiting NCT02501434 Phase 2 Continuous Low-Dose IV Unfractionated Heparin Infusion
45 Unruptured Intracranial Aneurysm Aspirin Trial (UIAAT). Not yet recruiting NCT03661463 Phase 2 Aspirin
46 Deferoxamine in Aneurysmal Subarachnoid Hemorrhage Trial Not yet recruiting NCT02875262 Phase 1, Phase 2 Deferoxamine
47 Deferiprone for Ruptured Brain Aneurysm Not yet recruiting NCT03754725 Phase 2 Deferiprone pill;placebo
48 Safety and Efficacy Study of a Single Dose of NA-1 in Patients Undergoing Endovascular Repair of Ruptured Aneurysms Withdrawn NCT02056574 Phase 2 NA-1;Placebo
49 Sildenafil for Prevention of Cerebral Vasospasm Withdrawn NCT01091870 Phase 2 Placebo;Sildenafil Citrate, 25 mg, 3 times a day.;Sildenafil Citrate 50 mg, 3 times a day
50 Safety Study of Sildenafil in Treatment of Cerebral Aneurysm Vasospasm Withdrawn NCT00871065 Phase 2 Sildenafil citrate

Search NIH Clinical Center for Intracranial Aneurysm

Cochrane evidence based reviews: intracranial aneurysm

Genetic Tests for Intracranial Aneurysm

Anatomical Context for Intracranial Aneurysm

MalaCards organs/tissues related to Intracranial Aneurysm:

42
Brain, Eye, Heart, Testes, Lung, Pituitary, Kidney

Publications for Intracranial Aneurysm

Articles related to Intracranial Aneurysm:

(show top 50) (show all 1549)
# Title Authors Year
1
Apc gene suppresses intracranial aneurysm formation and rupture through inhibiting the NF-κB signaling pathway mediated inflammatory response. ( 30808715 )
2019
2
Feasibility and efficacy of enhanced recovery after surgery protocol in Chinese elderly patients with intracranial aneurysm. ( 30774321 )
2019
3
Regrowth of a Large Intracranial Aneurysm after On-Label Use of the Pipeline Embolization Device. ( 30765991 )
2019
4
Heart-shaped intracranial aneurysm. ( 30758445 )
2019
5
Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation. ( 30737656 )
2019
6
Local Hemodynamic Conditions Associated with Focal Changes in the Intracranial Aneurysm Wall. ( 30733253 )
2019
7
Comparison of two preventive dual antiplatelet regimens for unruptured intracranial aneurysm embolization with flow diverter/disrupter: a matched-cohort study comparing Cclopidogrel with ticagrelor. ( 30731144 )
2019
8
Serum Cadmium Level Is Positively Associated with Unruptured Intracranial Aneurysm Incidence. ( 30727706 )
2019
9
Electroconvulsive Therapy After Flow Diversion Stenting of Intracranial Aneurysm. ( 30720553 )
2019
10
Differences in hemodynamic characteristics under high packing density between the porous media model and finite element analysis in computational fluid dynamics of intracranial aneurysm virtual treatment. ( 30718383 )
2019
11
Alport's syndrome and intracranial aneurysm: mere coincidence or undiscovered causal relationship. ( 30700471 )
2019
12
Braided stents and their impact in intracranial aneurysm treatment for distal locations: from flow diverters to low profile stents. ( 30686064 )
2019
13
Giant Intracranial Aneurysm Mimicking Brain Tumor. ( 30671167 )
2019
14
Neuroform Atlas Stent System for the treatment of intracranial aneurysm: primary results of the Atlas Humanitarian Device Exemption cohort. ( 30670625 )
2019
15
Treatment Strategy for Unruptured Intracranial Aneurysm in Elderly Patients: Coiling, Clipping, or Conservative? ( 30648433 )
2019
16
A prediction of postoperative neurological deficits following intracranial aneurysm surgery using somatosensory evoked potential deterioration duration. ( 30635746 )
2019
17
Potential Influences of Gut Microbiota on the Formation of Intracranial Aneurysm. ( 30624992 )
2019
18
Treatment of acute thromboembolic complication after stent-assisted coil embolization of ruptured intracranial aneurysm: a case report. ( 30613148 )
2019
19
Intraprocedural rupture management for intracranial aneurysm rupture during coil embolization by manual common carotid artery compression. ( 30612918 )
2019
20
Real-time Imaging of an Experimental Intracranial Aneurysm in Rats. ( 30555120 )
2019
21
Relationships between aneurysmal wall enhancement and conventional risk factors in patients with intracranial aneurysm: A high-resolution MRI study. ( 30389508 )
2019
22
Additive Manufacturing of 3D Biomodels as Adjuvant in Intracranial Aneurysm Clipping. ( 30357865 )
2019
23
Towards the Clinical utility of CFD for assessment of intracranial aneurysm rupture - a systematic review and novel parameter-ranking tool. ( 30341160 )
2019
24
Re-Recurrence of Intracranial Aneurysm with Proximal Vascular Stenosis After Primary Clipping and Secondary Endovascular Embolization: A Case Report and Literature Review. ( 30261388 )
2019
25
Prerupture Intracranial Aneurysm Morphology in Predicting Risk of Rupture: A Matched Case-Control Study. ( 29529238 )
2019
26
Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo. ( 30894565 )
2019
27
Rare Case of Absent Common Carotid Artery Likely Associated with Intracranial Aneurysm Development. ( 30879713 )
2019
28
Prediction of postoperative motor deficits using motor evoked potential deterioration duration in intracranial aneurysm surgery. ( 30878764 )
2019
29
Poor-Grade Aneurysmal Subarachnoid Hemorrhage: Risk Factors Affecting Clinical Outcomes in Intracranial Aneurysm Patients in a Multi-Center Study. ( 30873104 )
2019
30
Intracranial Aneurysm as a Macrophage-mediated Inflammatory Disease. ( 30867357 )
2019
31
Intravenous 3D digital subtraction angiography during surgical treatment of an intracranial aneurysm. ( 30862577 )
2019
32
In vitro accuracy and inter-observer reliability of CT angiography in detecting intracranial aneurysm enlargement. ( 30842308 )
2019
33
Pipeline embolisation device with shield technology for the treatment of ruptured intracranial aneurysm. ( 30839240 )
2019
34
Unruptured intracranial aneurysm growth trajectory: occurrence and rate of enlargement in 520 longitudinally followed cases. ( 30835694 )
2019
35
Genomic Variations in Susceptibility to Intracranial Aneurysm in the Korean Population. ( 30823506 )
2019
36
Aneurysm Characteristics, Study Population, and Endovascular Techniques for the Treatment of Intracranial Aneurysms in a Large, Prospective, Multicenter Cohort: Results of the Analysis of Recanalization after Endovascular Treatment of Intracranial Aneurysm Study. ( 30819769 )
2019
37
Hemodynamic Stress, Inflammation, and Intracranial Aneurysm Development and Rupture: A Systematic Review. ( 29709752 )
2018
38
A Highly Automated Computational Method for Modeling of Intracranial Aneurysm Hemodynamics. ( 29946264 )
2018
39
Surgery for Triple Pathology of Giant Vestibular Schwannoma Associated with Carotid Artery Stenosis and Intracranial Aneurysm: Case Report. ( 29977731 )
2018
40
3D printing of intracranial aneurysm based on intracranial digital subtraction angiography and its clinical application. ( 29901628 )
2018
41
Nontraumatic Acetabular Fracture Sustained during Convulsive Seizure Following Surgery for an Unruptured Intracranial Aneurysm: A Case Report. ( 29725569 )
2018
42
Meta-analysis of computed tomography angiography versus magnetic resonance angiography for intracranial aneurysm. ( 29768368 )
2018
43
Is fetal-type posterior cerebral artery a risk factor for intracranial aneurysm as analyzed by multislice CT angiography? ( 29434687 )
2018
44
Pros and Cons of Tentative Clipping in Intracranial Aneurysm Surgery: Review of 867 Direct Clippings in a Single Institution. ( 29966797 )
2018
45
Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis. ( 29301971 )
2018
46
Circumferential Thick Enhancement at Vessel Wall MRI Has High Specificity for Intracranial Aneurysm Instability. ( 29969070 )
2018
47
F2-isoprostanes and F4-neuroprostanes as markers of intracranial aneurysm development. ( 29790685 )
2018
48
Long-term outcomes of Low-profile Visualized Intraluminal Support device usage in stent-assisted coiling of intracranial aneurysm. ( 29422368 )
2018
49
Soluble Galectin 9 potently enhanced regulatory T cell formation, a pathway impaired in patients with intracranial aneurysm. ( 29978574 )
2018
50
Hemodynamics in a giant intracranial aneurysm characterized by in vitro 4D flow MRI. ( 29300738 )
2018

Variations for Intracranial Aneurysm

ClinVar genetic disease variations for Intracranial Aneurysm:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 FBN2 NM_001999.3(FBN2): c.2260G> A (p.Gly754Ser) single nucleotide variant Likely benign rs145259927 GRCh37 Chromosome 5, 127702112: 127702112
2 FBN2 NM_001999.3(FBN2): c.2260G> A (p.Gly754Ser) single nucleotide variant Likely benign rs145259927 GRCh38 Chromosome 5, 128366419: 128366419

Copy number variations for Intracranial Aneurysm from CNVD:

7 (show top 50) (show all 60)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 39938 10 12200000 22600000 Loss Intracranial aneurysm
2 47489 10 94100000 97000000 Amplification HHEX Intracranial aneurysm
3 57447 11 63400000 77100000 Amplification FADD Intracranial aneurysm
4 58058 11 65900000 70400000 Gain Intracranial aneurysm
5 58059 11 65900000 75200000 Gain Intracranial aneurysm
6 61265 11 97200000 110400000 Amplification BIRC2 Intracranial aneurysm
7 61266 11 97200000 110400000 Amplification BIRC3 Intracranial aneurysm
8 65029 12 14800000 26500000 Amplification SLC21A8 Intracranial aneurysm
9 67921 12 46400000 58100000 Amplification PFKM Intracranial aneurysm
10 67922 12 46400000 58100000 Amplification SENP1 Intracranial aneurysm
11 75163 13 17900000 115169878 Copy number Intracranial aneurysm
12 77541 13 45200000 59600000 Copy number Intracranial aneurysm
13 79537 13 73300000 79000000 Amplification Intracranial aneurysm
14 87453 14 73800000 79300000 Gain Intracranial aneurysm
15 119789 18 17200000 19000000 Amplification Intracranial aneurysm
16 122647 18 59000000 73100000 Loss Intracranial aneurysm
17 133739 19 6900000 14000000 Amplification RAD23A Intracranial aneurysm
18 135805 2 121010413 121052286 Amplification RALB Intracranial aneurysm
19 140407 2 197400000 209000000 Amplification ALS2 Intracranial aneurysm
20 140408 2 197400000 209000000 Amplification BMPR2 Intracranial aneurysm
21 140409 2 197400000 209000000 Amplification CYP20A1 Intracranial aneurysm
22 140410 2 197400000 209000000 Amplification NOP5 Intracranial aneurysm
23 140411 2 197400000 209000000 Amplification SUMO1 Intracranial aneurysm
24 140412 2 197400000 209000000 Amplification WDR12 Intracranial aneurysm
25 150455 20 1 5100000 Gain Intracranial aneurysm
26 152629 20 32100000 34400000 Gain Intracranial aneurysm
27 154535 20 46400000 49800000 Gain Intracranial aneurysm
28 155818 20 58400000 63025520 Gain Intracranial aneurysm
29 164525 22 37600000 51304566 Amplification PLXNB2 Intracranial aneurysm
30 168338 3 129200000 138700000 Amplification RAB6B Intracranial aneurysm
31 171398 3 167401694 167452651 Amplification PDCD10 Intracranial aneurysm
32 171571 3 169755735 169803181 Amplification Intracranial aneurysm
33 172483 3 182700000 187900000 Amplification LAMP3 Intracranial aneurysm
34 172484 3 182700000 187900000 Amplification MCCC1 Intracranial aneurysm
35 173254 3 192300000 198022430 Amplification TFRC Intracranial aneurysm
36 189115 4 70500000 76300000 Loss Intracranial aneurysm
37 191657 5 1 4500000 Gain Intracranial aneurysm
38 191840 5 10250281 10266501 Amplification CCT5 Intracranial aneurysm
39 194596 5 14143828 14509458 Amplification TRIO Intracranial aneurysm
40 199711 5 42500000 46100000 Gain Intracranial aneurysm
41 202898 5 892968 918164 Amplification TRIP13 Intracranial aneurysm
42 226168 7 55086724 55275031 Amplification EGFR Intracranial aneurysm
43 232751 8 119200000 127300000 Gain Intracranial aneurysm
44 234358 8 134048972 134115310 Amplification SLA Intracranial aneurysm
45 234391 8 134203281 134243932 Amplification WISP1 Intracranial aneurysm
46 234397 8 134249413 134309547 Amplification NDRG1 Intracranial aneurysm
47 239116 8 37701397 37707431 Amplification BRF2 Intracranial aneurysm
48 239184 8 37963348 37997228 Amplification ASH2L Intracranial aneurysm
49 239226 8 38132560 38239790 Amplification WHSC1L1 Intracranial aneurysm
50 239696 8 41119475 41166990 Amplification SFRP1 Intracranial aneurysm

Expression for Intracranial Aneurysm

Search GEO for disease gene expression data for Intracranial Aneurysm.

Pathways for Intracranial Aneurysm

Pathways related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 CDKN2B COL1A2 COL3A1 ELN FBN2 LIMK1
2
Show member pathways
13.09 COL1A2 COL3A1 ELN FBN2 LIMK1 MMP2
3
Show member pathways
12.8 COL1A2 COL3A1 ELN FBN2 VCAN
4
Show member pathways
12.55 ACE2 COL1A2 COL3A1 ELN LOX
5
Show member pathways
11.82 COL1A2 COL3A1 ELN FBN2 LOX MMP2
6 11.76 COL1A2 COL3A1 NOS3
7 11.6 ENG MMP2 NOS3
8
Show member pathways
11.6 COL1A2 COL3A1 ELN FBN2 LIMK1 MMP2
9 11.56 COL1A2 COL3A1 MMP2 NOS3
10
Show member pathways
11.5 ELN FBN2 LOX
11 11.24 COL1A2 COL3A1 MMP2 VCAN
12 11.08 COL1A2 MMP2 NOS3
13 11.07 ACE2 MMP2
14 10.96 MMP2 NOS3
15 10.93 ENG FBN2
16 10.89 ACE2 MMP2
17 10.7 COL1A2 COL3A1 ELN FBN2 LIMK1 VCAN

GO Terms for Intracranial Aneurysm

Cellular components related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.87 ACE2 COL1A2 COL3A1 ENG LOX MMP2
2 extracellular region GO:0005576 9.81 ACE2 COL1A2 COL3A1 ELN FBN2 LOX
3 collagen trimer GO:0005581 9.43 COL1A2 COL3A1 LOX
4 collagen-containing extracellular matrix GO:0062023 9.43 COL1A2 COL3A1 ELN FBN2 MMP2 VCAN
5 extracellular matrix GO:0031012 9.17 COL1A2 COL3A1 ELN FBN2 LOX MMP2

Biological processes related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.81 CDKN2B-AS1 ENG NOS3 SOX17
2 heart development GO:0007507 9.71 COL3A1 ENG LOX PKD1
3 angiogenesis GO:0001525 9.67 ENG MMP2 NOS3 SOX17
4 renal system development GO:0072001 9.49 PKD1 SOX17
5 aortic valve morphogenesis GO:0003180 9.48 ELN NOS3
6 endocardial cushion morphogenesis GO:0003203 9.46 ENG NOS3
7 response to fluid shear stress GO:0034405 9.43 NOS3 PKD1
8 cellular response to amino acid stimulus GO:0071230 9.43 COL1A2 COL3A1 MMP2
9 blood vessel development GO:0001568 9.33 COL1A2 COL3A1 PKD1
10 bone trabecula formation GO:0060346 9.32 FBN2 MMP2
11 collagen fibril organization GO:0030199 9.13 COL1A2 COL3A1 LOX
12 extracellular matrix organization GO:0030198 9.02 COL1A2 COL3A1 ELN FBN2 VCAN

Molecular functions related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.83 ACE2 CDKN2B CDKN2B-AS1 COL1A2 COL3A1 ELN
2 glycosaminoglycan binding GO:0005539 9.32 ENG VCAN
3 platelet-derived growth factor binding GO:0048407 9.26 COL1A2 COL3A1
4 extracellular matrix constituent conferring elasticity GO:0030023 9.16 ELN FBN2
5 extracellular matrix structural constituent GO:0005201 8.92 COL1A2 COL3A1 ELN FBN2

Sources for Intracranial Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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