MCID: INT030
MIFTS: 55

Intracranial Aneurysm

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Intracranial Aneurysm

MalaCards integrated aliases for Intracranial Aneurysm:

Name: Intracranial Aneurysm 12 54 6 44 15 71
Brain Aneurysm 12 53 54 6 42 17 71
Cerebral Arterial Aneurysm 71
Intracranial Aneurysms 15

Classifications:



External Ids:

Disease Ontology 12 DOID:10941
MeSH 44 D002532
NCIt 50 C34458
SNOMED-CT 67 128609009
UMLS 71 C0007766 C0751003 C1290398

Summaries for Intracranial Aneurysm

NINDS : 53 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.  A cerebral aneurysm can press on a nerve or surrounding tissue in the brain, and also leak or burst, which lets blood spill into surrounding tissues (called a hemorrhage). Cerebral aneurysms can occur at any age, although they are more common in adults than in children and are more common in women than in men. These aneurysms can occur anywhere in the brain. Some small aneurysms may not show signs and are usually detected during imaging tests for other medical conditions. The signs and symptoms of an unruptured cerebral aneurysm will partly depend on its size and rate of growth. A larger aneurysm that is steadily growing may produce symptoms such as numbness, pain above and behind the eye, and paralysis on one side of the face. Immediately after an aneurysm ruptures, an individual may experience such symptoms as a sudden and unusually severe headache, nausea, vision impairment, vomiting, and loss of consciousness.

MalaCards based summary : Intracranial Aneurysm, also known as brain aneurysm, is related to aneurysm and intracranial berry aneurysm, and has symptoms including seizures, tremor and back pain. An important gene associated with Intracranial Aneurysm is PKD1 (Polycystin 1, Transient Receptor Potential Channel Interacting), and among its related pathways/superpathways are Collagen chain trimerization and Degradation of the extracellular matrix. The drugs Sevoflurane and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and eye, and related phenotypes are cardiovascular system and cellular

MedlinePlus : 42 A brain aneurysm is an abnormal bulge or "ballooning" in the wall of an artery in the brain. They are sometimes called berry aneurysms because they are often the size of a small berry. Most brain aneurysms produce no symptoms until they become large, begin to leak blood, or burst. If a brain aneurysm presses on nerves in your brain, it can cause signs and symptoms. These can include A droopy eyelid Double vision or other changes in vision Pain above or behind the eye A dilated pupil Numbness or weakness on one side of the face or body Treatment depends on the size and location of the aneurysm, whether it is infected, and whether it has burst. If a brain aneurysm bursts, symptoms can include a sudden, severe headache, nausea and vomiting, stiff neck, loss of consciousness, and signs of a stroke. Any of these symptoms requires immediate medical attention. NIH: National Heart, Lung, and Blood Institute

Wikipedia : 74 An intracranial aneurysm, also known as a brain aneurysm, is a cerebrovascular disorder in which... more...

Related Diseases for Intracranial Aneurysm

Diseases related to Intracranial Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 485)
# Related Disease Score Top Affiliating Genes
1 aneurysm 32.3 THSD1 LOX FBN2 ELN COL3A1 CDKN2B-AS1
2 intracranial berry aneurysm 31.7 THSD1 PKD1 NOS3 EDNRA APOE
3 carotid stenosis 30.8 NOS3 CDKN2B-AS1 APOE
4 autosomal dominant polycystic kidney disease 30.4 PKD1 NOS3 FBN2 EDNRA
5 aortic dissection 30.3 LOX FBN2 ELN COL3A1
6 loeys-dietz syndrome 30.3 FBN2 ELN COL3A1
7 aortic aneurysm 30.3 MIR145 LOX FBN2 ELN COL3A1 CDKN2B-AS1
8 brittle bone disorder 30.2 LOX ENG ELN COL3A1 COL1A2
9 collagen disease 30.2 ELN COL3A1 COL1A2
10 stroke, ischemic 30.2 NOS3 ENG EDNRA CDKN2B-AS1 APOE
11 vascular disease 30.1 NOS3 MIR145 MIR143 ENG ELN APOE
12 arteriosclerosis 30.1 NOS3 LOX ELN EDNRA APOE
13 arteriovenous malformations of the brain 30.1 STARD13 SOX17 ENG CDKN2B-AS1
14 marfan syndrome 30.1 PKD1 LOX FBN2 ELN COL3A1 COL1A2
15 aortic disease 30.1 MIR145 LOX ELN COL3A1
16 intraocular pressure quantitative trait locus 30.0 ELN EDNRA CDKN2B-AS1
17 aortic aneurysm, familial abdominal, 1 30.0 NOS3 LOX ELN COL3A1 CDKN2B-AS1 APOE
18 nervous system cancer 29.9 MIR145 MIR143 CDKN2B-AS1 CDKN2B CDKN2A
19 connective tissue disease 29.8 MIR145 MIR143 LOX FBN2 ELN EDNRA
20 chronic kidney disease 29.8 PKD1 NOS3 ELN APOE ACE2
21 homocysteinemia 29.8 NOS3 ELN APOE
22 atherosclerosis susceptibility 29.8 NOS3 ELN CDKN2B-AS1 APOE
23 orthostatic intolerance 29.6 PKD1 NOS3 FBN2 ELN COL3A1 COL1A2
24 arteries, anomalies of 29.5 NOS3 MIR145 MIR143 APOE
25 cardiovascular system disease 29.2 NOS3 MIR145 MIR143 ELN EDNRA CDKN2B-AS1
26 lipoprotein quantitative trait locus 29.0 NOS3 MIR145 MIR143 ENG ELN CDKN2B-AS1
27 hypertension, essential 28.8 PKD1 NOS3 MIR145 MIR143 LOX ENG
28 heart disease 28.8 SOX17 NOS3 MIR145 MIR143 LOX ENG
29 angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps 11.2
30 polycystic kidney disease 1 with or without polycystic liver disease 11.2
31 aneurysm, intracranial berry, 1 11.1
32 fibromuscular dysplasia 11.1
33 aneurysm, intracranial berry, 6 11.1
34 aneurysm, intracranial berry, 10 11.1
35 aneurysm, intracranial berry, 3 11.1
36 aneurysm, intracranial berry, 4 11.1
37 aneurysm, intracranial berry, 8 11.1
38 aneurysm, intracranial berry, 9 11.1
39 aneurysm, intracranial berry, 11 11.1
40 aneurysm, intracranial berry, 12 11.1
41 immunodeficiency 31c 11.1
42 microcephalic osteodysplastic primordial dwarfism, type ii 11.0
43 aneurysm, intracranial berry, 5 11.0
44 aneurysm, intracranial berry, 7 11.0
45 loeys-dietz syndrome 4 11.0
46 cerebral aneurysms 10.8
47 hydrocephalus 10.6
48 polycystic kidney disease 10.5
49 familial abdominal aortic aneurysm 10.4 ELN COL3A1
50 arteriovenous malformation 10.4

Graphical network of the top 20 diseases related to Intracranial Aneurysm:



Diseases related to Intracranial Aneurysm

Symptoms & Phenotypes for Intracranial Aneurysm

UMLS symptoms related to Intracranial Aneurysm:


seizures, tremor, back pain, angina pectoris, chest pain, headache, syncope, edema, pain, chronic pain, sciatica, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Intracranial Aneurysm:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.37 ACE2 APOE CDKN2A COL1A2 COL3A1 EDNRA
2 cellular MP:0005384 10.32 ACE2 APOE CDKN2A CDKN2B COL1A2 COL3A1
3 hematopoietic system MP:0005397 10.3 ACE2 APOE CDKN2A CDKN2B COL1A2 COL3A1
4 growth/size/body region MP:0005378 10.29 ACE2 APOE CDKN2A COL1A2 COL3A1 EDNRA
5 homeostasis/metabolism MP:0005376 10.28 ACE2 APOE CDKN2A CDKN2B COL1A2 COL3A1
6 immune system MP:0005387 10.18 ACE2 APOE CDKN2A CDKN2B COL1A2 COL3A1
7 digestive/alimentary MP:0005381 10.15 ACE2 APOE CDKN2A COL3A1 EDNRA ENG
8 adipose tissue MP:0005375 10.14 APOE COL1A2 COL3A1 FBN2 NOS3 PKD1
9 integument MP:0010771 10.11 ACE2 APOE CDKN2A CDKN2B COL1A2 COL3A1
10 mortality/aging MP:0010768 10 ACE2 APOE CDKN2A CDKN2B COL1A2 COL3A1
11 limbs/digits/tail MP:0005371 9.87 APOE COL1A2 ENG FBN2 LOX NOS3
12 liver/biliary system MP:0005370 9.8 APOE CDKN2A COL3A1 FBN2 NOS3 PKD1
13 muscle MP:0005369 9.73 ACE2 APOE CDKN2A COL1A2 COL3A1 EDNRA
14 respiratory system MP:0005388 9.32 ACE2 APOE CDKN2A COL3A1 EDNRA ENG

Drugs & Therapeutics for Intracranial Aneurysm

Drugs for Intracranial Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 141)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
2
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
3
Ticagrelor Approved Phase 4 274693-27-5 9871419
4
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
5
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
6
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
7
Levetiracetam Approved Phase 4 102767-28-2 441341
8 Hypnotics and Sedatives Phase 4
9 Anesthetics, Inhalation Phase 4
10 Anesthetics, Intravenous Phase 4
11 Adrenergic alpha-Agonists Phase 4
12 Adrenergic Agents Phase 4
13 Adrenergic Agonists Phase 4
14 Neurotransmitter Agents Phase 4
15 Analgesics, Non-Narcotic Phase 4
16 Analgesics Phase 4
17 Anti-Inflammatory Agents Phase 4
18 Cyclooxygenase Inhibitors Phase 4
19 Anti-Inflammatory Agents, Non-Steroidal Phase 4
20 Antirheumatic Agents Phase 4
21 Antipyretics Phase 4
22 Purinergic P2Y Receptor Antagonists Phase 4
23 Anti-Asthmatic Agents Phase 4
24 Respiratory System Agents Phase 4
25 Prasugrel hydrochloride Phase 4 389574-19-0
26 Neuroprotective Agents Phase 4
27 Bronchodilator Agents Phase 4
28 Anticonvulsants Phase 4
29
Simvastatin Approved Phase 3 79902-63-9 54454
30
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
31
Esmolol Approved Phase 3 81147-92-4, 103598-03-4 59768
32
Heparin Approved, Investigational Phase 3 9005-49-6 772 9812414
33
Bivalirudin Approved, Investigational Phase 3 128270-60-0 16129704
34
Vitamin D3 Approved, Nutraceutical Phase 2, Phase 3 67-97-0 6221 5280795
35
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 1406-16-2
36 Anesthetics Phase 3
37 Nutrients Phase 2, Phase 3
38 Micronutrients Phase 2, Phase 3
39 Trace Elements Phase 2, Phase 3
40 Vitamins Phase 2, Phase 3
41 Calciferol Phase 2, Phase 3
42 Platelet Aggregation Inhibitors Phase 3
43 Anesthetics, General Phase 3
44 Protective Agents Phase 2, Phase 3
45 Adrenergic Antagonists Phase 3
46 Adrenergic beta-Antagonists Phase 3
47 Adrenergic beta-1 Receptor Antagonists Phase 3
48 Cerebrolysin Phase 2, Phase 3
49 Salicylates Phase 3
50 calcium heparin Phase 3

Interventional clinical trials:

(show top 50) (show all 264)
# Name Status NCT ID Phase Drugs
1 Comparative Study of Covered Stent With Coil Embolization in the Treatment of Cranial Internal Carotid Artery Aneurysm: A Nonrandomized Prospective Trial Unknown status NCT01029938 Phase 4
2 Randomized Comparison of Platelet Function Monitoring to Adjust Antiplatelet Therapy Versus a Common Antiplatelet Treatment for Intracranial Aneurysm Stent-assisted Coiling Unknown status NCT02224131 Phase 4 Aspirin and clopidogrel;Aspirin and clopidogrel
3 Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function in Patients Undergoing Intracranial Aneurysm Surgery. Completed NCT02691416 Phase 4 propofol postconditioning;sevoflurane
4 Aneurysm Wall Histology and Correlation With Cerebrospinal Fluid and Blood Plasma Registry Completed NCT01444664 Phase 4
5 A Prospective, Randomized, Multicenter Trial Investigating Matrix 2® and GDC® Detachable Coils for the Treatment of Intracranial Saccular Aneurysms Completed NCT00396981 Phase 4
6 Sevoflurane, Laryngeal Mask Airway and Single-dose Dexmedetomidine: A Better Choice for Patients Undergoing Endovascular Coil Embolization Completed NCT01722409 Phase 4 sevoflurane and 0.5 μg/kg dexmedetomidine;sevoflurane and 1 μg/kg dexmedetomidine
7 A Study of Platelet Function Test in the Application of Prevention of Ischemic Events After Stent Placement in Intracranial Aneurysms Completed NCT03989557 Phase 4 Aspirin and clopidogrel/Ticagrelor;Aspirin and clopidogrel/Ticagrelor
8 PRET: Patients Prone to Recurrence After Endovascular Treatment. A Randomized Trial Comparing Platinum and Hydrogel-coated Coils Completed NCT00626912 Phase 4
9 Stenting in the Treatment of Large, Wide-necked or Recurring Intracranial Aneurysms Recruiting NCT01340612 Phase 4
10 Comparison of Dual-Antiplatelet and Triple-Antiplatelet Preparation Using P2Y12 Assay in Patients With High On-Treatment Platelet Reactivity Undergoing Stent-Assisted Coil Embolization for An Unruptured Intracranial Aneurysm Recruiting NCT03581409 Phase 4 Aspirin;Prasugrel;Clopidogrel;Cilostazol
11 Seizure Prophylaxis in Aneurysm Repair Active, not recruiting NCT01801072 Phase 4 Levetiracetam
12 Effect of Preoperative Intravenous Ferric Carboxymaltose on Postoperative Transfusion Reduction in Anemia Patients Scheduled for Clipping Surgery for Unruptured Intracranial Aneurysms Not yet recruiting NCT04616092 Phase 4 FEFINJECT
13 Seizure Prophylaxis in Aneurysm Repair Terminated NCT01974700 Phase 4 Levetiracetam
14 LARGE Aneurysm Randomized Trial: Flow Diversion Versus Traditional Endovascular Coiling Therapy Terminated NCT01762137 Phase 4
15 HydroCoil Cerebral Aneurysm Treatment Trial Terminated NCT01195129 Phase 4
16 Hydrogel Balloon Assisted Intracranial Aneurysm Coiling Registry Withdrawn NCT02037932 Phase 4
17 Comparison of Esmolol and Dexmedetomidine on Sympathetic Control During Intracranial Procedures Unknown status NCT02563288 Phase 3 Esmolol;Dexmedetomidine
18 A Feasibility Study of the MicroVention,Inc.(LVIS™) Neurovascular Self-Expanding Retrievable Stent System in the Treatment of Wide-Necked Intracranial Artery Aneurysms Completed NCT01541254 Phase 2, Phase 3
19 Simvastatin in Aneurysmal Subarachnoid Haemorrhage (STASH) a Multicentre Randomised Controlled Clinical Trial Completed NCT00731627 Phase 3 placebo;simvastatin
20 Randomized Clinical Trial of Hypovitaminosis D Treatment in the Neurocritical Care Unit Completed NCT02881957 Phase 2, Phase 3 Cholecalciferol
21 Ticagrelor Versus Clopidogrel for Platelet Inhibition in Patients Undergoing Neurovascular Stenting for Intracranial Aneurysm Completed NCT02675205 Phase 3 Clopidogrel;Ticagrelor;aspirin
22 Hypothermia During Intracranial Aneurysm Surgery Trial Completed NCT00029133 Phase 3
23 Complete Occlusion of Coilable Aneurysms Completed NCT00777907 Phase 3
24 Randomized, Double-blind, Placebo-controlled Pilot Trial to Investigate Safety and Efficacy of Cerebrolysin™ in Patients With Aneurysmal Subarachnoid Hemorrhage Completed NCT01787123 Phase 2, Phase 3 Intravenous Cerebrolysin;Normal Saline
25 Esmolol Reduces Anesthetic Requirements Thereby Facilitating Early Extubation; a Prospective Controlled Study in Patients Undergoing Intracranial Surgery Completed NCT02455440 Phase 3 Esmolol;Placebo;Propofol and sevoflurane
26 Prospective Randomized Open-label Trial to Evaluate Risk faCTor Management in Patients With Unruptured Intracranial Aneurysms Recruiting NCT03063541 Phase 3 Acetylsalicylic acid
27 Evaluating Oral Peri-operative Acetylsalicylic Acid in Subjects Undergoing Endovascular Coiling-only of Unruptured Brain Aneurysms(EVOLVE): A Phase 3 Multicenter Randomized Study Recruiting NCT04192955 Phase 3 Acetyl Salicylate
28 A Prospective, Multi-center, Single Arm Study to Evaluate the Safety and Effectiveness of the PulseRider® Aneurysm Neck Reconstruction Device Used in Conjunction With Endovascular Coil Embolization in the Treatment of Wide-Neck Bifurcation Intracranial Aneurysm Active, not recruiting NCT03383666 Phase 3
29 Anticoagulant Efficacy and Safety of BivalirUdin Versus heparIn During coiL Embolization in Patients With ruptureD Intracranial Aneurysms: an Open-label, Multicenter, Randomized Pilot Study(BUILD) Not yet recruiting NCT04532333 Phase 3 Bivalirudin 250 MG Injection;Heparin
30 Deferoxamine in Aneurysmal Subarachnoid Hemorrhage Trial Unknown status NCT02875262 Phase 1, Phase 2 Deferoxamine
31 Clevidipine for Vasospasm After Subarachnoid Hemorrhage Unknown status NCT02011321 Phase 2 clevidipine
32 Nimodipine Microparticles to Enhance Recovery While Reducing TOxicity After subarachNoid Hemorrhage: Phase I/IIa Multicenter, Controlled, Randomized, Open Label, Dose Escalation, Safety, Tolerability, and Pharmacokinectic Study Comparing EG-1962 and Nimodipine in Patients With Aneurysmal Subarachnoid Hemorrhage Completed NCT01893190 Phase 1, Phase 2 Nimodipine;Nimodipine Microparticles
33 A Phase II, Multicenter, Randomized, Fasting, Double-Blind, Placebo-Controlled, Safety, Tolerability and Efficacy Study Evaluating a Single Dose of Intravenous NA-1 in Male and Female Patients Undergoing Endovascular Repair of Brain Aneurysms Completed NCT00728182 Phase 2 NA-1;Placebo
34 A Randomised Controlled Trial of Aspirin Versus no Treatment to Reduce Aneurysm Wall Inflammation in Unruptured Intracranial Aneurysms. Recruiting NCT03661463 Phase 2 Aspirin
35 Application of Atorvastatin in the Treatment of Patients With Intracranial Unruptured Aneurysms Recruiting NCT04149483 Phase 2 Atorvastatin;Placebos
36 A Blind-adjudication Multi-center Phase II Randomized Clinical Trial of Continuous Low-dose Intravenous Heparin Therapy in Coiled Low-grade Aneurysmal Subarachnoid Hemorrhage Patients With Significant Hemorrhage Burden Recruiting NCT02501434 Phase 2 Continuous Low-Dose IV Unfractionated Heparin Infusion
37 Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms Not yet recruiting NCT04141020 Phase 2 Sirolimus
38 Efficacy of 10 Days Intravenous Milrinone Treatment to Optimize Cerebral Hemodynamic and Prevent Delayed Cerebral Ischemia (DCI) in Patients With Severe Subarachnoid Hemorrhage Due to Intracranial Aneurysm Rupture Not yet recruiting NCT04282629 Phase 2 Milrinone Injection
39 Safety and Performance of the Penumbra Liberty Stent in the Treatment of Wide-Neck, Saccular, Intracranial Aneurysms Withdrawn NCT01753388 Phase 2
40 Phase 2, Multicenter Randomized, Double-Blind, Placebo-Controlled, Safety and Efficacy Study Evaluating a Single Dose of Intravenous NA-1 in Patients With Subarachnoid Hemorrhage Undergoing Endovascular Repair of Ruptured Intracranial Aneurysms Withdrawn NCT02056574 Phase 2 NA-1;Placebo
41 Sildenafil for Prevention of Cerebral Vasospasm Secondary to Subarachnoid Haemorrhage - Phase II Randomized Clinical Trial Withdrawn NCT01091870 Phase 2 Placebo;Sildenafil Citrate, 25 mg, 3 times a day.;Sildenafil Citrate 50 mg, 3 times a day
42 Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage Withdrawn NCT01878136 Phase 1, Phase 2 Tissue Plasminogen Activator
43 Estrogen Therapy as Prevention in the Progression of Aneurysm Withdrawn NCT01895881 Phase 2 Estradiol;Placebo
44 Prophylactic Remote Ischemic Preconditioning for Cerebral Vasospasm Following Subarachnoid Hemorrhage Completed NCT01158508 Phase 1
45 Aspirin as a Promising Agent to Attenuate Inflammation in the Wall of Human Cerebral Aneurysms Completed NCT01710072 Phase 1 aspirin
46 Influence of Matrix Metalloproteinase on Brain Arteriovenous Malformation Hemorrhage Completed NCT00783523 Phase 1 Doxycycline or Placebo
47 Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRI Enrolling by invitation NCT03084523 Phase 1 Ferumoxytol Injectable Product
48 A Multi-center Pilot Study Evaluating the Safety and Feasibility of the eCLIPs™ Family of Products for the Treatment of Unruptured Bifurcation Intracranial Aneurysms Withdrawn NCT01957683 Phase 1
49 TARGET Intracranial Aneurysm Coiling Registry: A Prospective Clinical Efficacy and Safety Study of Stryker Target® 360°, Target® Helical, and 2nd Generation Target® Nano Coils Unknown status NCT01748903
50 Post Market Multi-Center Retrospective Research on Embolization of Intracranial Aneurysms With Pipeline Embolization Device in China (PLUS) Unknown status NCT03831672

Search NIH Clinical Center for Intracranial Aneurysm

Cochrane evidence based reviews: intracranial aneurysm

Genetic Tests for Intracranial Aneurysm

Anatomical Context for Intracranial Aneurysm

MalaCards organs/tissues related to Intracranial Aneurysm:

40
Brain, Kidney, Eye, Pituitary, Endothelial, Smooth Muscle, Whole Blood

Publications for Intracranial Aneurysm

Articles related to Intracranial Aneurysm:

(show top 50) (show all 4475)
# Title Authors PMID Year
1
The association of CDKN2BAS gene polymorphisms and intracranial aneurysm: A meta-analysis. 61 42
33285697 2020
2
Comparison of surgical clipping and endovascular coiling in the treatment of oculomotor nerve palsy caused by posterior communicating artery aneurysm. 42
33217799 2020
3
Incidental cerebral aneurysms detected by a computer-assisted detection system based on artificial intelligence: A case series. 42
33120725 2020
4
Elastase-induced intracranial aneurysms in hypertensive mice. 54 61
19884566 2009
5
[Correlation of COL3A1 gene with type III collagen stability in intracranial aneurysm]. 54 61
18642782 2008
6
Evidence in favor of the contribution of genes involved in the maintenance of the extracellular matrix of the arterial wall to the development of intracranial aneurysms. 54 61
17038484 2006
7
A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms. 61 54
16611674 2006
8
Association analysis of common variants of ELN, NOS2A, APOE and ACE2 to intracranial aneurysm. 61 54
16574921 2006
9
Genetics of intracranial aneurysms. 61 54
15721828 2005
10
The presence of tandem endothelial nitric oxide synthase gene polymorphisms identifying brain aneurysms more prone to rupture. 54 61
15796389 2005
11
Absence of alpha-1 antitrypsin deficiency alleles (S and Z) in Japanese and Korean patients with aneurysmal subarachnoid hemorrhage. 61 54
15528457 2004
12
Update on genetic evidence for rupture-prone compared with rupture-resistant intracranial saccular aneurysms. 54 61
15633984 2004
13
Endothelial nitric oxide synthase gene polymorphisms predict susceptibility to aneurysmal subarachnoid hemorrhage and cerebral vasospasm. 61 54
15091109 2004
14
Collagen type I alpha2 (COL1A2) is the susceptible gene for intracranial aneurysms. 61 54
14739420 2004
15
Mutations in the lysyl oxidase gene not associated with intracranial aneurysm in central European families. 54 61
15273433 2004
16
Endoglin is not a major susceptibility gene for intracranial aneurysm among Japanese. 61 54
12775886 2003
17
Association of mutation position in polycystic kidney disease 1 (PKD1) gene and development of a vascular phenotype. 61 54
12842373 2003
18
Elastin polymorphism haplotype and intracranial aneurysms are not associated in Central Europe. 61 54
12690215 2003
19
Absence of linkage of familial intracranial aneurysms to 7q11 in highly aggregated Japanese families. 54 61
12649519 2003
20
Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm. 61 54
12750963 2003
21
Elastase-induced saccular aneurysms in rabbits: comparison of geometric features with those of human aneurysms. 54 61
11733310 2001
22
Type III collagen deficiency in saccular intracranial aneurysms. Defect in gene regulation? 54 61
10436112 1999
23
Metalloproteases and intracranial vascular lesions. 61 54
10406011 1999
24
The Unruptured Intracranial Aneurysm Treatment Score as a predictor of aneurysm growth or rupture. 61
33175449 2021
25
Circular RNA expression profile in human primary multiple intracranial aneurysm. 61
33603847 2021
26
New technique: the use of the THRIVE sequence in the follow-up of patients who received endovascular intracranial aneurysm treatment. 61
32914366 2021
27
Biomodex patient-specific brain aneurysm models: the value of simulation for first in-human experiences using new devices and robotics. 61
32601259 2021
28
Endoscopic Muscle Repair of Right Internal Carotid Artery Rupture Following Endovascular Procedure. 61
32745245 2021
29
Henle fibre layer haemorrhage: clinical features and pathogenesis. 61
32376610 2021
30
A Commentary on "The prognostic effects of hemodynamic parameters on rupture of intracranial aneurysm: A systematic review and meta-analysis" (Int J Surg. 2021; 86:15-23). 61
33582282 2021
31
Histone deacetylase 9 inhibition upregulates microRNA-92a to repress the progression of intracranial aneurysm via silencing Bcl-2-like protein 11. 61
33480300 2021
32
Significant flow velocity reduction at the intracranial aneurysm neck after endovascular treatment leads to favourable angiographic outcome: a prospective study. 61
33526635 2021
33
Pharmacological inhibition of STAT3 by BP-1-102 inhibits intracranial aneurysm formation and rupture in mice through modulating inflammatory response. 61
33474811 2021
34
Efficacy and safety of PulseRider for treatment of wide-necked intracranial aneurysm-A systematic review and meta-analysis. 61
32635777 2021
35
Comparative Assessment of Extracranial-to-Intracranial and Intracranial-to-Intracranial In Situ Bypass for Complex Intracranial Aneurysm Treatment Based on Rupture Status: A Case Series. 61
33075570 2021
36
Impact of Neurovascular Comorbidities and Complications on Outcomes After Procedural Management of Intracranial Aneurysm: Part 1, Unruptured Intracranial Aneurysm. 61
33122142 2021
37
Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms. 61
32034564 2021
38
Relationship between Deep White Matter Hyperintensities on Magnetic Resonance Imaging and Postoperative Cognitive Function Following Clipping of Unruptured Intracranial Aneurysm. 61
33390419 2021
39
A Supplemental Technique for Preoperative Evaluation of Giant Intracranial Aneurysm. 61
33583010 2021
40
Low-Dose 3D Rotational Angiography in Measuring the Size of Intracranial Aneurysm: In Vitro Feasibility Study Using Aneurysm Phantom. 61
33596630 2021
41
Intracranial aneurysm and coarctation of the aorta: prevalence in the current era. 61
33153502 2021
42
Clinical Interrogation of Mandatory Insertion of Central Venous Catheter for Clipping Surgery of Unruptured Intracranial Aneurysm: A Propensity Score Matched Study. 61
33250188 2021
43
Impact of Neurovascular Comorbidities and Complications on Outcomes After Procedural Management of Intracranial Aneurysm: Part 2, Ruptured Intracranial Aneurysm. 61
33470214 2021
44
Concentration of Lp(a) (Lipoprotein[a]) in Aneurysm Sac Is Associated With Wall Enhancement of Unruptured Intracranial Aneurysm. 61
33563021 2021
45
Republished: Interhospital teleproctoring of endovascular intracranial aneurysm treatment using a dedicated live-streaming technology: first experiences during the COVID-19 pandemic. 61
33082292 2021
46
Aneurysmal Subarachnoid Hemorrhage: Trends, Outcomes, and Predictions From a 15-Year Perspective of a Single Neurocritical Care Unit. 61
33313810 2021
47
Impact of COVID-19 pandemic on patients with intracranial aneurysm rupture. 61
33340837 2021
48
Location of intracranial aneurysms is the main factor associated with rupture in the ICAN population. 61
33097563 2021
49
Cardiac sarcoidosis masquerading as ventricular tachycardia storm: a challenging diagnosis. 61
33563689 2021
50
The prognostic effects of hemodynamic parameters on rupture of intracranial aneurysm: A systematic review and meta-analysis. 61
33444872 2021

Variations for Intracranial Aneurysm

ClinVar genetic disease variations for Intracranial Aneurysm:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 PKD1 NM_001009944.3(PKD1):c.2079dup (p.Pro694fs) Duplication Pathogenic 374141 rs1057518923 16:2165396-2165397 16:2115395-2115396
2 FBN2 NM_001999.4(FBN2):c.2260G>A (p.Gly754Ser) SNV Uncertain significance 213286 rs145259927 5:127702112-127702112 5:128366419-128366419

Copy number variations for Intracranial Aneurysm from CNVD:

7 (show top 50) (show all 60)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 39938 10 12200000 22600000 Loss Intracranial aneurysm
2 47489 10 94100000 97000000 Amplification HHEX Intracranial aneurysm
3 57447 11 63400000 77100000 Amplification FADD Intracranial aneurysm
4 58058 11 65900000 70400000 Gain Intracranial aneurysm
5 58059 11 65900000 75200000 Gain Intracranial aneurysm
6 61265 11 97200000 110400000 Amplification BIRC2 Intracranial aneurysm
7 61266 11 97200000 110400000 Amplification BIRC3 Intracranial aneurysm
8 65029 12 14800000 26500000 Amplification SLCO1B3 Intracranial aneurysm
9 67921 12 46400000 58100000 Amplification PFKM Intracranial aneurysm
10 67922 12 46400000 58100000 Amplification SENP1 Intracranial aneurysm
11 75163 13 17900000 115169878 Copy number Intracranial aneurysm
12 77541 13 45200000 59600000 Copy number Intracranial aneurysm
13 79537 13 73300000 79000000 Amplification Intracranial aneurysm
14 87453 14 73800000 79300000 Gain Intracranial aneurysm
15 119789 18 17200000 19000000 Amplification Intracranial aneurysm
16 122647 18 59000000 73100000 Loss Intracranial aneurysm
17 133739 19 6900000 14000000 Amplification RAD23A Intracranial aneurysm
18 135805 2 121010413 121052286 Amplification RALB Intracranial aneurysm
19 140407 2 197400000 209000000 Amplification ALS2 Intracranial aneurysm
20 140408 2 197400000 209000000 Amplification BMPR2 Intracranial aneurysm
21 140409 2 197400000 209000000 Amplification CYP20A1 Intracranial aneurysm
22 140410 2 197400000 209000000 Amplification NOP58 Intracranial aneurysm
23 140411 2 197400000 209000000 Amplification SUMO1 Intracranial aneurysm
24 140412 2 197400000 209000000 Amplification WDR12 Intracranial aneurysm
25 150455 20 1 5100000 Gain Intracranial aneurysm
26 152629 20 32100000 34400000 Gain Intracranial aneurysm
27 154535 20 46400000 49800000 Gain Intracranial aneurysm
28 155818 20 58400000 63025520 Gain Intracranial aneurysm
29 164525 22 37600000 51304566 Amplification PLXNB2 Intracranial aneurysm
30 168338 3 129200000 138700000 Amplification RAB6B Intracranial aneurysm
31 171398 3 167401694 167452651 Amplification PDCD10 Intracranial aneurysm
32 171571 3 169755735 169803181 Amplification Intracranial aneurysm
33 172483 3 182700000 187900000 Amplification LAMP3 Intracranial aneurysm
34 172484 3 182700000 187900000 Amplification MCCC1 Intracranial aneurysm
35 173254 3 192300000 198022430 Amplification TFRC Intracranial aneurysm
36 189115 4 70500000 76300000 Loss Intracranial aneurysm
37 191657 5 1 4500000 Gain Intracranial aneurysm
38 191840 5 10250281 10266501 Amplification CCT5 Intracranial aneurysm
39 194596 5 14143828 14509458 Amplification TRIO Intracranial aneurysm
40 199711 5 42500000 46100000 Gain Intracranial aneurysm
41 202898 5 892968 918164 Amplification TRIP13 Intracranial aneurysm
42 226168 7 55086724 55275031 Amplification EGFR Intracranial aneurysm
43 232751 8 119200000 127300000 Gain Intracranial aneurysm
44 234358 8 134048972 134115310 Amplification SLA Intracranial aneurysm
45 234391 8 134203281 134243932 Amplification CCN4 Intracranial aneurysm
46 234397 8 134249413 134309547 Amplification NDRG1 Intracranial aneurysm
47 239116 8 37701397 37707431 Amplification BRF2 Intracranial aneurysm
48 239184 8 37963348 37997228 Amplification ASH2L Intracranial aneurysm
49 239226 8 38132560 38239790 Amplification NSD3 Intracranial aneurysm
50 239696 8 41119475 41166990 Amplification SFRP1 Intracranial aneurysm

Expression for Intracranial Aneurysm

Search GEO for disease gene expression data for Intracranial Aneurysm.

Pathways for Intracranial Aneurysm

GO Terms for Intracranial Aneurysm

Cellular components related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.35 FBN2 ELN COL3A1 COL1A2 APOE
2 collagen trimer GO:0005581 9.33 LOX COL3A1 COL1A2
3 extracellular matrix GO:0031012 9.1 LOX FBN2 ELN COL3A1 COL1A2 APOE

Biological processes related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.93 SOX17 NOS3 ENG CDKN2B-AS1 CDKN2A
2 transforming growth factor beta receptor signaling pathway GO:0007179 9.73 ENG COL3A1 COL1A2
3 wound healing GO:0042060 9.72 LOX ENG COL3A1
4 actin cytoskeleton organization GO:0030036 9.71 STARD13 MIR145 MIR143 LIMK1
5 regulation of blood pressure GO:0008217 9.65 NOS3 EDNRA COL1A2
6 blood vessel development GO:0001568 9.61 PKD1 LOX COL1A2
7 regulation of proteasomal protein catabolic process GO:0061136 9.6 PKD1 APOE
8 negative regulation of phosphorylation GO:0042326 9.59 CDKN2B CDKN2A
9 regulation of smooth muscle contraction GO:0006940 9.58 MIR145 MIR143
10 nitric oxide mediated signal transduction GO:0007263 9.58 NOS3 APOE
11 endocardial cushion morphogenesis GO:0003203 9.57 NOS3 ENG
12 extracellular matrix organization GO:0030198 9.55 LOX FBN2 ELN COL3A1 COL1A2
13 collagen fibril organization GO:0030199 9.54 LOX COL3A1 COL1A2
14 negative regulation of ubiquitin-protein transferase activity GO:0051444 9.52 LIMK1 CDKN2A
15 angiotensin-activated signaling pathway GO:0038166 9.51 MIR145 MIR143
16 negative regulation of platelet activation GO:0010544 9.49 NOS3 APOE
17 response to fluid shear stress GO:0034405 9.46 PKD1 NOS3
18 aorta smooth muscle tissue morphogenesis GO:0060414 9.32 MIR145 MIR143
19 regulation of phenotypic switching GO:1900239 9.26 MIR145 MIR143
20 heart development GO:0007507 9.1 SOX17 PKD1 LOX ENG EDNRA COL3A1
21 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 8.96 MIR145 MIR143

Molecular functions related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.26 CDKN2B CDKN2A
2 platelet-derived growth factor binding GO:0048407 9.16 COL3A1 COL1A2
3 extracellular matrix constituent conferring elasticity GO:0030023 8.96 FBN2 ELN
4 extracellular matrix structural constituent GO:0005201 8.92 FBN2 ELN COL3A1 COL1A2

Sources for Intracranial Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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