MCID: INT030
MIFTS: 57

Intracranial Aneurysm

Categories: Cardiovascular diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Intracranial Aneurysm

MalaCards integrated aliases for Intracranial Aneurysm:

Name: Intracranial Aneurysm 12 55 44 15 73
Brain Aneurysm 12 54 55 6 43 73
Cerebral Arterial Aneurysm 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10941
MeSH 44 D002532
NCIt 50 C34458
SNOMED-CT 68 128609009 42994005

Summaries for Intracranial Aneurysm

NINDS : 54 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.  A cerebral aneurysm can press on a nerve or surrounding tissue in the brain, and also leak or burst, which lets blood spill into surrounding tissues (called a hemorrhage). Cerebral aneurysms can occur at any age, although they are more common in adults than in children and are more common in women than in men. These aneurysms can occur anywhere in the brain. Some small aneurysms may not show signs and are usually detected during imaging tests for other medical conditions. The signs and symptoms of an unruptured cerebral aneurysm will partly depend on its size and rate of growth. A larger aneurysm that is steadily growing may produce symptoms such as numbness, pain above and behind the eye, and paralysis on one side of the face. Immediately after an aneurysm ruptures, an individual may experience such symptoms as a sudden and unusually severe headache, nausea, vision impairment, vomiting, and loss of consciousness.

MalaCards based summary : Intracranial Aneurysm, also known as brain aneurysm, is related to aneurysm and arteriovenous malformations of the brain, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Intracranial Aneurysm is CDKN2B-AS1 (CDKN2B Antisense RNA 1
A genetic susceptibility locus.
Dysfunction Pattern: Regulation [down-regulated]), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Benzocaine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related phenotypes are cardiovascular system and cellular

MedlinePlus : 43 A brain aneurysm is an abnormal bulge or "ballooning" in the wall of an artery in the brain. They are sometimes called berry aneurysms because they are often the size of a small berry. Most brain aneurysms produce no symptoms until they become large, begin to leak blood, or burst. If a brain aneurysm presses on nerves in your brain, it can cause signs and symptoms. These can include A droopy eyelid Double vision or other changes in vision Pain above or behind the eye A dilated pupil Numbness or weakness on one side of the face or body Treatment depends on the size and location of the aneurysm, whether it is infected, and whether it has burst. If a brain aneurysm bursts, symptoms can include a sudden, severe headache, nausea and vomiting, stiff neck, loss of consciousness, and signs of a stroke. Any of these symptoms requires immediate medical attention. NIH: National Heart, Lung, and Blood Institute

Wikipedia : 76 Intracranial aneurysm, also known as brain aneurysm, is a cerebrovascular disorder in which weakness in... more...

Related Diseases for Intracranial Aneurysm

Diseases in the Intracranial Aneurysm family:

Intracranial Aneurysms Multiple Congenital Anomaly

Diseases related to Intracranial Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 aneurysm 30.7 COL3A1 ELN FBN2 LOX PKD1
2 arteriovenous malformations of the brain 30.2 CDKN2B-AS1 ENG SOX17
3 orthostatic intolerance 29.1 ELN FBN2 NOS3
4 marfan syndrome 29.1 COL1A2 COL3A1 ELN FBN2
5 connective tissue disease 29.1 COL1A2 COL3A1 ELN FBN2
6 supravalvular aortic stenosis 29.0 ELN LIMK1
7 aortic aneurysm 28.7 CDKN2B-AS1 COL3A1 ELN FBN2 LOX
8 intracranial aneurysms multiple congenital anomaly 12.0
9 fibromuscular dysplasia 11.5
10 polycystic kidney disease 1 with or without polycystic liver disease 11.2
11 intracranial berry aneurysm 11.1
12 aneurysm, intracranial berry, 1 11.0
13 aneurysm, intracranial berry, 5 11.0
14 aneurysm, intracranial berry, 3 11.0
15 aneurysm, intracranial berry, 4 11.0
16 aneurysm, intracranial berry, 6 11.0
17 aneurysm, intracranial berry, 7 11.0
18 aneurysm, intracranial berry, 8 11.0
19 aneurysm, intracranial berry, 9 11.0
20 aneurysm, intracranial berry, 10 11.0
21 immunodeficiency 31c 11.0
22 aneurysm, intracranial berry, 11 11.0
23 loeys-dietz syndrome 4 11.0
24 abducens nerve disease 10.8
25 familial cerebral saccular aneurysm 10.6 COL3A1 ENG
26 familial abdominal aortic aneurysm 10.5 COL3A1 ELN
27 ehlers-danlos syndrome, vascular type 10.5 COL3A1 ELN
28 larsen-like syndrome 10.5 COL1A2 COL3A1
29 cerebritis 10.3
30 lipoblastoma 10.3 COL1A2 COL3A1
31 collagen disease 10.3 COL1A2 COL3A1 ELN
32 kidney disease 10.2
33 polycystic kidney disease 10.2
34 phacogenic glaucoma 10.2 ELN LOX
35 pelvic organ prolapse 10.2 COL3A1 ELN LOX
36 autosomal dominant polycystic kidney disease 10.2
37 ehlers-danlos syndrome, classic type, 1 10.1 COL1A2 COL3A1
38 endotheliitis 10.1
39 glaucoma, primary open angle 10.1 CDKN2B CDKN2B-AS1 ELN
40 thrombosis 10.1
41 tendinopathy 10.0 NOS3 VCAN
42 arteriovenous malformation 10.0
43 carotid stenosis 10.0
44 open-angle glaucoma 9.9 CDKN2B CDKN2B-AS1 ELN
45 moyamoya disease 1 9.9
46 tuberous sclerosis 9.9
47 ischemia 9.9
48 cerebral aneurysms 9.9
49 aging 9.9
50 anxiety 9.9

Graphical network of the top 20 diseases related to Intracranial Aneurysm:



Diseases related to Intracranial Aneurysm

Symptoms & Phenotypes for Intracranial Aneurysm

UMLS symptoms related to Intracranial Aneurysm:


angina pectoris, back pain, chest pain, edema, headache, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Intracranial Aneurysm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.16 COL1A2 LOX COL3A1 NOS3 ACE2 ENG
2 cellular MP:0005384 10.09 FBN2 LIMK1 COL1A2 COL3A1 ACE2 CDKN2B
3 homeostasis/metabolism MP:0005376 10.06 COL1A2 LOX COL3A1 NOS3 ACE2 ENG
4 growth/size/body region MP:0005378 10.02 FBN2 COL1A2 COL3A1 ACE2 ENG SOX17
5 mortality/aging MP:0010768 9.9 FBN2 COL1A2 LOX COL3A1 ACE2 ENG
6 adipose tissue MP:0005375 9.88 COL1A2 COL3A1 PKD1 THSD1 NOS3
7 digestive/alimentary MP:0005381 9.88 COL3A1 ACE2 ENG SOX17 NOS3 PKD1
8 integument MP:0010771 9.8 COL1A2 LOX COL3A1 ACE2 ENG CDKN2B
9 muscle MP:0005369 9.61 LOX COL3A1 NOS3 ACE2 ENG FBN2
10 respiratory system MP:0005388 9.17 LOX COL3A1 NOS3 ACE2 ENG FBN2

Drugs & Therapeutics for Intracranial Aneurysm

Drugs for Intracranial Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 162)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 4,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
2
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
3
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Not Applicable 28523-86-6 5206
4
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 113775-47-6 68602 5311068
5
Desflurane Approved Phase 4 57041-67-5 42113
6
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
7
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 1 50-78-2 2244
8 Piracetam Approved, Investigational Phase 4 7491-74-9
9
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
10
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
11 tannic acid Approved, Nutraceutical Phase 4,Not Applicable,Early Phase 1
12 Etiracetam Investigational Phase 4 33996-58-6
13 Anesthetics Phase 4,Phase 3,Not Applicable
14 Anesthetics, General Phase 4,Phase 3,Not Applicable
15 Anesthetics, Inhalation Phase 4,Phase 3,Not Applicable
16 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable
17 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 1,Not Applicable
18 Analgesics Phase 4,Phase 3,Phase 1,Not Applicable
19 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Not Applicable
21 Anticonvulsants Phase 4,Phase 2,Not Applicable
22 Neuroprotective Agents Phase 4,Phase 2,Phase 3
23 Nootropic Agents Phase 4,Phase 2,Phase 3
24 Protective Agents Phase 4,Phase 2,Phase 3
25 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Anesthetics, Intravenous Phase 4,Phase 3
27 Hypnotics and Sedatives Phase 4,Phase 3,Not Applicable
28 Adrenergic Agents Phase 4,Phase 3,Not Applicable
29 Adrenergic Agonists Phase 4,Phase 3,Not Applicable
30 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3,Not Applicable
31 Adrenergic alpha-Agonists Phase 4,Phase 3,Not Applicable
32 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1,Not Applicable
33 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1
34 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 1
35 Antipyretics Phase 4,Phase 3,Phase 1
36 Antirheumatic Agents Phase 4,Phase 3,Phase 1
37 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 1
38 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
39 Purinergic P2 Receptor Antagonists Phase 4,Phase 3
40 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3
41
Simvastatin Approved Phase 3 79902-63-9 54454
42
Esmolol Approved Phase 3 103598-03-4, 81147-92-4 59768
43
Ticagrelor Approved Phase 3 274693-27-5 9871419
44
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3 50-14-6 5280793
45
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 1406-16-2
46
Vitamin D3 Approved, Nutraceutical Phase 2, Phase 3,Phase 3 67-97-0 6221 5280795
47 Cerebrolysin Phase 2, Phase 3
48 Antimetabolites Phase 3,Not Applicable
49 Hypolipidemic Agents Phase 3,Not Applicable
50 Lipid Regulating Agents Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 230)
# Name Status NCT ID Phase Drugs
1 Treatment of Cranial Internal Carotid Artery Aneurysm With Willis Covered Stent and Coil Embolization Unknown status NCT01029938 Phase 4
2 Delayed Vasospasm After Aneurysm With the Standardization Treatment of Traditional Chinese Medicine Unknown status NCT01840761 Phase 4 herbal drug;placebo
3 The Registry to Study Safety and Performance of the CORDIS Vascular Reconstruction Device and Delivery System Completed NCT00486226 Phase 4
4 Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function Completed NCT02691416 Phase 4 propofol postconditioning;sevoflurane
5 PRET: Patients Prone to Recurrence After Endovascular Treatment Completed NCT00626912 Phase 4
6 A Better Choice for Patients Undergoing Endovascular Coil Embolization Completed NCT01722409 Phase 4 sevoflurane and 0.5 μg/kg dexmedetomidine;sevoflurane and 1 μg/kg dexmedetomidine
7 MAPS Trial: Matrix And Platinum Science Completed NCT00396981 Phase 4
8 Aneurysm Wall Histology Registry Completed NCT01444664 Phase 4
9 Comparison of Neuroprotection by Propofol and Desflurane for POCD Following Subarachnoid Hemorrhage Surgery Completed NCT02987218 Phase 4 Propofol;Desflurane
10 TARGET Intracranial Aneurysm Coiling Registry Recruiting NCT01748903 Phase 4
11 Flow Diversion in Intracranial Aneurysm Treatment Recruiting NCT01349582 Phase 4
12 Stenting in the Treatment of Aneurysm Trial Recruiting NCT01340612 Phase 4
13 Comparison of Two Different Antiplatelet Preparations for an Unruptured Intracranial Aneurysm Recruiting NCT03581409 Phase 4 Aspirin;Prasugrel;Clopidogrel;Cilostazol
14 Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil Recruiting NCT02729740 Phase 4
15 Seizure Prophylaxis in Aneurysm Repair Recruiting NCT01801072 Phase 4 Levetiracetam
16 Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions Recruiting NCT02478346 Phase 4 Fluorescein Sodium
17 HYdrogel Coil Versus Bare Platinum Coil in Recanalization Imaging Data Study Active, not recruiting NCT01516658 Phase 4
18 Study of the Penumbra Coil 400 System to Treat Aneurysm Active, not recruiting NCT01465841 Phase 4
19 Study of Antiplatelet Therapy for Intracranial Aneurysm Stent-assisted Coiling Not yet recruiting NCT02224131 Phase 4 Aspirin and clopidogrel;Aspirin and clopidogrel
20 Seizure Prophylaxis in Aneurysm Repair Terminated NCT01974700 Phase 4 Levetiracetam
21 LARGE Aneurysm Randomized Trial: Flow Diversion Versus Traditional Endovascular Coiling Therapy Terminated NCT01762137 Phase 4
22 HydroCoil Cerebral Aneurysm Treatment Trial Terminated NCT01195129 Phase 4
23 Hydrogel Balloon Assisted Intracranial Aneurysm Coiling Registry Withdrawn NCT02037932 Phase 4
24 Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety and Efficacy of Cerebrolysin™ in Patients With Aneurysmal Subarachnoid Hemorrhage Unknown status NCT01787123 Phase 2, Phase 3 Intravenous Cerebrolysin
25 The Penumbra Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms Completed NCT01636453 Phase 3
26 Feasibility Study of the LVIS™ (Low-profile Visualized Intraluminal Support)Device Completed NCT01541254 Phase 2, Phase 3
27 Complete Occlusion of Coilable Aneurysms Completed NCT00777907 Phase 3
28 Hypothermia During Intracranial Aneurysm Surgery Trial Completed NCT00029133 Phase 3
29 Simvastatin in Aneurysmal Subarachnoid Haemorrhage (STASH) a Multicentre Randomised Controlled Clinical Trial Completed NCT00731627 Phase 3 placebo;simvastatin
30 Esmolol Infusion in Patients Undergoing Craniotomy Completed NCT02455440 Phase 3 Esmolol;Placebo;Propofol and sevoflurane
31 Acetylsalicylic Acid Plus Intensive Blood Pressure Treatment in Patients With Unruptured Intracranial Aneurysms Recruiting NCT03063541 Phase 3 Acetylsalicylic acid
32 Ticagrelor vs Clopidogrel for Platelet Inhibition in Stenting for Cerebral Aneurysm Recruiting NCT02675205 Phase 3 Clopidogrel;Ticagrelor;aspirin
33 Esmolol Versus Dexmedetomidine During Intracranial Procedures Recruiting NCT02563288 Phase 3 Esmolol;Dexmedetomidine
34 The Neuroprotective Effect of Remote Ischemic Conditioning in Aneurysm Coiling Therapy Recruiting NCT03496415 Phase 2, Phase 3
35 Pivotal Study of the FRED Stent System in the Treatment of Intracranial Aneurysms Active, not recruiting NCT01801007 Phase 3
36 Hypovitaminosis D in Neurocritical Patients Active, not recruiting NCT02881957 Phase 2, Phase 3 Cholecalciferol
37 A Study Evaluating the Safety and Effectiveness of the PulseRider® Aneurysm Neck Reconstruction Device Used in Conjunction With Endovascular Coil Embolization in the Treatment of Wide-Neck Bifurcation Intracranial Aneurysm Not yet recruiting NCT03383666 Phase 3
38 The Neuroprotective Effect of Remote Ischemic Conditioning in Ruptured Aneurysm Coiling Therapy Not yet recruiting NCT03561311 Phase 2, Phase 3
39 Intraventricular Fibrinolysis for Aneurysmal Subarachnoid Hemorrhage. Not yet recruiting NCT03187405 Phase 3 EVD + IVF with Alteplase
40 Intraventricular Tissue Plasminogen Activator (tPA) in the Management of Aneurysmal Subarachnoid Hemorrhage Unknown status NCT01098890 Phase 2 Tissue Plasminogen Activator;Placebo
41 Clevidipine for Vasospasm After Subarachnoid Hemorrhage (SAH) Unknown status NCT02011321 Phase 2 clevidipine
42 Safety and Efficacy Study of Clevidipine to Control Hypertension in Patients Admitted With Aneurysmal Subarachnoid Hemorrhage Unknown status NCT00978822 Phase 2 Clevidipine butyrate injectable emulsion
43 Safety and Tolerability Study of EG-1962 in Aneurysmal Subarachnoid Hemorrhage Completed NCT01893190 Phase 1, Phase 2 Nimodipine;Nimodipine Microparticles
44 Evaluating Neuroprotection in Aneurysm Coiling Therapy Completed NCT00728182 Phase 2 NA-1;Placebo
45 Evaluation of the Efficacy and Safety of Clazosentan in Reversing Cerebral Vasospasm in Adult Subjects With Aneurysmal Subarachnoid Hemorrhage Completed NCT02560532 Phase 2 Clazosentan
46 Estrogen Therapy as Prevention in the Progression of Aneurysm (EPPA) Trial Recruiting NCT01895881 Phase 2 Estradiol;Placebo
47 Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin Recruiting NCT02501434 Phase 2 Continuous Low-Dose IV Unfractionated Heparin Infusion
48 Safety and Performance of the Penumbra Liberty Stent in the Treatment of Wide-Neck, Saccular, Intracranial Aneurysms Active, not recruiting NCT01753388 Phase 2
49 Deferoxamine in Aneurysmal Subarachnoid Hemorrhage Trial Not yet recruiting NCT02875262 Phase 1, Phase 2 Deferoxamine
50 Safety and Efficacy Study of a Single Dose of NA-1 in Patients Undergoing Endovascular Repair of Ruptured Aneurysms Withdrawn NCT02056574 Phase 2 NA-1;Placebo

Search NIH Clinical Center for Intracranial Aneurysm

Cochrane evidence based reviews: intracranial aneurysm

Genetic Tests for Intracranial Aneurysm

Anatomical Context for Intracranial Aneurysm

MalaCards organs/tissues related to Intracranial Aneurysm:

41
Brain, Eye, Heart, Testes, Lung, Kidney, Endothelial

Publications for Intracranial Aneurysm

Articles related to Intracranial Aneurysm:

(show top 50) (show all 889)
# Title Authors Year
1
Hemodynamic Stress, Inflammation, and Intracranial Aneurysm Development and Rupture: A Systematic Review. ( 29709752 )
2018
2
A Highly Automated Computational Method for Modeling of Intracranial Aneurysm Hemodynamics. ( 29946264 )
2018
3
Surgery for Triple Pathology of Giant Vestibular Schwannoma Associated with Carotid Artery Stenosis and Intracranial Aneurysm: Case Report. ( 29977731 )
2018
4
3D printing of intracranial aneurysm based on intracranial digital subtraction angiography and its clinical application. ( 29901628 )
2018
5
Nontraumatic Acetabular Fracture Sustained during Convulsive Seizure Following Surgery for an Unruptured Intracranial Aneurysm: A Case Report. ( 29725569 )
2018
6
Meta-analysis of computed tomography angiography versus magnetic resonance angiography for intracranial aneurysm. ( 29768368 )
2018
7
Is fetal-type posterior cerebral artery a risk factor for intracranial aneurysm as analyzed by multislice CT angiography? ( 29434687 )
2018
8
Pros and Cons of Tentative Clipping in Intracranial Aneurysm Surgery: Review of 867 Direct Clippings in a Single Institution. ( 29966797 )
2018
9
Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis. ( 29301971 )
2018
10
Circumferential Thick Enhancement at Vessel Wall MRI Has High Specificity for Intracranial Aneurysm Instability. ( 29969070 )
2018
11
F2-isoprostanes and F4-neuroprostanes as markers of intracranial aneurysm development. ( 29790685 )
2018
12
Long-term outcomes of Low-profile Visualized Intraluminal Support device usage in stent-assisted coiling of intracranial aneurysm. ( 29422368 )
2018
13
Soluble Galectin 9 potently enhanced regulatory T cell formation, a pathway impaired in patients with intracranial aneurysm. ( 29978574 )
2018
14
Hemodynamics in a giant intracranial aneurysm characterized by in vitro 4D flow MRI. ( 29300738 )
2018
15
Anatomical evaluation of intracranial aneurysm rupture risk in patients with multiple aneurysms. ( 29959638 )
2018
16
Association of SOX17 Gene Polymorphisms and Intracranial Aneurysm: A Case-Control Study and Meta-Analysis. ( 29191544 )
2018
17
Circulating neutrophil transcriptome may reveal intracranial aneurysm signature. ( 29342213 )
2018
18
Aneurysm Size is the Strongest Risk Factor for Intracranial Aneurysm Growth in the Eastern Finnish Population. ( 29767773 )
2018
19
Bleb formation in small unruptured intracranial aneurysm as a predictor of early rupture. ( 29977511 )
2018
20
Combining monoenergetic extrapolations from dual-energy CT with iterative reconstructions: reduction of coil and clip artifacts from intracranial aneurysm therapy. ( 29356855 )
2018
21
Experimental study of the characteristics of various types of filling coils for intracranial aneurysm embolisation. ( 29921151 )
2018
22
Intracranial Aneurysm Wall Enhancement Associated with Aneurysm Rupture: A Systematic Review and Meta-analysis. ( 29908979 )
2018
23
Clip ligation for ruptured intracranial aneurysm in a child with Loeys-Dietz syndrome: case report. ( 29350591 )
2018
24
Evaluation of Application Value of Transcranial Doppler (TCD) in the Inspection of Cerebral Vasospasm After the Treatment of Intracranial Aneurysm. ( 29399014 )
2018
25
China Intracranial Aneurysm Project (CIAP): protocol for a prospective cohort study of interventional treatment and craniotomy for unruptured aneurysms. ( 29794089 )
2018
26
The application of the unruptured intracranial aneurysm treatment score: a retrospective, single-center study. ( 29388120 )
2018
27
Bioinformatic analysis of gene expression profiling of intracranial aneurysm. ( 29328431 )
2018
28
Myeloperoxidase Associates With Degenerative Remodeling and Rupture of the Saccular Intracranial Aneurysm Wall. ( 29718300 )
2018
29
Number of Cigarettes Smoked Per Day, Smoking Index, and Intracranial Aneurysm Rupture: A Case-Control Study. ( 29904368 )
2018
30
Rare Coding Variants in ANGPTL6 Are Associated with Familial Forms of Intracranial Aneurysm. ( 29304371 )
2018
31
Intracranial Aneurysm is Associated with High Intracranial Artery Tortuosity. ( 29425982 )
2018
32
Factors influencing the incidence and treatment of intracranial aneurysm and subarachnoid hemorrhage: time trends and socioeconomic disparities under an universal healthcare system. ( 29934441 )
2018
33
MedinaAr Embolization Device for the Treatment of Intracranial Aneurysms: Safety and Angiographic Effectiveness at 6 Months. ( 28402453 )
2018
34
Exome Sequencing Identifies LOXL2 Mutation as a Cause of Familial Intracranial Aneurysm. ( 29107163 )
2018
35
TLR4 gene polymorphisms rs11536889 is associated with intracranial aneurysm susceptibility. ( 29754966 )
2018
36
Aortic Coarctation Complicated with Intracranial Aneurysm: A Case Report and Literature Review. ( 29325938 )
2018
37
Clinical outcomes after craniotomy for unruptured intracranial aneurysm in patients with coronary artery disease. ( 28887082 )
2017
38
Genetic associations of intracranial aneurysm formation and sub-arachnoid hemorrhage. ( 28761511 )
2017
39
Unruptured intracranial aneurysm and first episode psychosis: The mystery was finally solved. ( 28953760 )
2017
40
Novel ELN mutation in a family with supravalvular aortic stenosis and intracranial aneurysm. ( 27866049 )
2017
41
Vascular Tissue-Type Plasminogen Activator Promotes Intracranial Aneurysm Formation. ( 28754830 )
2017
42
Methodology for Computational Fluid Dynamic Validation for Medical Use: Application to Intracranial Aneurysm. ( 28857116 )
2017
43
Rapid Development of Intracranial Aneurysm Associated with Tuberculous Meningitis. ( 29391085 )
2017
44
Regulation of Kruppel-like factor 2 (KLF2) in the pathogenesis of intracranial aneurysm induced by hemodynamics. ( 29312497 )
2017
45
Acute stent thrombosis after stent-assisted coiling in an intracranial aneurysm patient carrying two reduced-function CYP2C19 alleles: A case report. ( 29382029 )
2017
46
Cervical artery tortuosity is associated with intracranial aneurysm. ( 28073311 )
2017
47
Variants of the elastin (ELN) gene and susceptibility to intracranial aneurysm: a synthesis of genetic association studies using a genetic model-free approach. ( 27687579 )
2017
48
Small versus Large Ruptured Intracranial Aneurysm: Concerns with the Site of Aneurysm. ( 28088803 )
2017
49
Natural history of intracranial aneurysms in autosomal dominant polycystic kidney disease. ( 28843770 )
2017
50
MiR-29b Downregulation Induces Phenotypic Modulation of Vascular Smooth Muscle Cells: Implication for Intracranial Aneurysm Formation and Progression to Rupture. ( 28214880 )
2017

Variations for Intracranial Aneurysm

ClinVar genetic disease variations for Intracranial Aneurysm:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 FBN2 NM_001999.3(FBN2): c.2260G> A (p.Gly754Ser) single nucleotide variant Likely benign rs145259927 GRCh38 Chromosome 5, 128366419: 128366419
2 FBN2 NM_001999.3(FBN2): c.2260G> A (p.Gly754Ser) single nucleotide variant Likely benign rs145259927 GRCh37 Chromosome 5, 127702112: 127702112

Copy number variations for Intracranial Aneurysm from CNVD:

7 (show top 50) (show all 60)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 39938 10 12200000 22600000 Loss Intracranial aneurysm
2 47489 10 94100000 97000000 Amplification HHEX Intracranial aneurysm
3 57447 11 63400000 77100000 Amplification FADD Intracranial aneurysm
4 58058 11 65900000 70400000 Gain Intracranial aneurysm
5 58059 11 65900000 75200000 Gain Intracranial aneurysm
6 61265 11 97200000 110400000 Amplification BIRC2 Intracranial aneurysm
7 61266 11 97200000 110400000 Amplification BIRC3 Intracranial aneurysm
8 65029 12 14800000 26500000 Amplification SLC21A8 Intracranial aneurysm
9 67921 12 46400000 58100000 Amplification PFKM Intracranial aneurysm
10 67922 12 46400000 58100000 Amplification SENP1 Intracranial aneurysm
11 75163 13 17900000 115169878 Copy number Intracranial aneurysm
12 77541 13 45200000 59600000 Copy number Intracranial aneurysm
13 79537 13 73300000 79000000 Amplification Intracranial aneurysm
14 87453 14 73800000 79300000 Gain Intracranial aneurysm
15 119789 18 17200000 19000000 Amplification Intracranial aneurysm
16 122647 18 59000000 73100000 Loss Intracranial aneurysm
17 133739 19 6900000 14000000 Amplification RAD23A Intracranial aneurysm
18 135805 2 121010413 121052286 Amplification RALB Intracranial aneurysm
19 140407 2 197400000 209000000 Amplification ALS2 Intracranial aneurysm
20 140408 2 197400000 209000000 Amplification BMPR2 Intracranial aneurysm
21 140409 2 197400000 209000000 Amplification CYP20A1 Intracranial aneurysm
22 140410 2 197400000 209000000 Amplification NOP5 Intracranial aneurysm
23 140411 2 197400000 209000000 Amplification SUMO1 Intracranial aneurysm
24 140412 2 197400000 209000000 Amplification WDR12 Intracranial aneurysm
25 150455 20 1 5100000 Gain Intracranial aneurysm
26 152629 20 32100000 34400000 Gain Intracranial aneurysm
27 154535 20 46400000 49800000 Gain Intracranial aneurysm
28 155818 20 58400000 63025520 Gain Intracranial aneurysm
29 164525 22 37600000 51304566 Amplification PLXNB2 Intracranial aneurysm
30 168338 3 129200000 138700000 Amplification RAB6B Intracranial aneurysm
31 171398 3 167401694 167452651 Amplification PDCD10 Intracranial aneurysm
32 171571 3 169755735 169803181 Amplification Intracranial aneurysm
33 172483 3 182700000 187900000 Amplification LAMP3 Intracranial aneurysm
34 172484 3 182700000 187900000 Amplification MCCC1 Intracranial aneurysm
35 173254 3 192300000 198022430 Amplification TFRC Intracranial aneurysm
36 189115 4 70500000 76300000 Loss Intracranial aneurysm
37 191657 5 1 4500000 Gain Intracranial aneurysm
38 191840 5 10250281 10266501 Amplification CCT5 Intracranial aneurysm
39 194596 5 14143828 14509458 Amplification TRIO Intracranial aneurysm
40 199711 5 42500000 46100000 Gain Intracranial aneurysm
41 202898 5 892968 918164 Amplification TRIP13 Intracranial aneurysm
42 226168 7 55086724 55275031 Amplification EGFR Intracranial aneurysm
43 232751 8 119200000 127300000 Gain Intracranial aneurysm
44 234358 8 134048972 134115310 Amplification SLA Intracranial aneurysm
45 234391 8 134203281 134243932 Amplification WISP1 Intracranial aneurysm
46 234397 8 134249413 134309547 Amplification NDRG1 Intracranial aneurysm
47 239116 8 37701397 37707431 Amplification BRF2 Intracranial aneurysm
48 239184 8 37963348 37997228 Amplification ASH2L Intracranial aneurysm
49 239226 8 38132560 38239790 Amplification WHSC1L1 Intracranial aneurysm
50 239696 8 41119475 41166990 Amplification SFRP1 Intracranial aneurysm

Expression for Intracranial Aneurysm

Search GEO for disease gene expression data for Intracranial Aneurysm.

Pathways for Intracranial Aneurysm

Pathways related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 CDKN2B COL1A2 COL3A1 ELN FBN2 LIMK1
2
Show member pathways
13.09 COL1A2 COL3A1 ELN FBN2 LIMK1 VCAN
3
Show member pathways
12.69 COL1A2 COL3A1 ELN FBN2 VCAN
4
Show member pathways
12.28 ACE2 COL1A2 COL3A1 ELN LOX
5
Show member pathways
11.75 COL1A2 COL3A1 ELN FBN2 LOX VCAN
6 11.63 COL1A2 COL3A1 NOS3
7 11.49 COL1A2 COL3A1 NOS3
8
Show member pathways
11.3 ELN FBN2 LOX
9 11.04 COL1A2 NOS3
10 11.01 COL1A2 COL3A1
11 10.92 COL1A2 COL3A1 VCAN
12 10.83 ENG FBN2

GO Terms for Intracranial Aneurysm

Cellular components related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 ACE2 COL1A2 COL3A1 ELN FBN2 LOX
2 collagen trimer GO:0005581 9.13 COL1A2 COL3A1 LOX
3 extracellular matrix GO:0031012 9.02 COL1A2 COL3A1 ELN FBN2 VCAN

Biological processes related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.58 COL1A2 COL3A1 VCAN
2 heart development GO:0007507 9.56 COL3A1 ENG LOX PKD1
3 renal system development GO:0072001 9.37 PKD1 SOX17
4 collagen fibril organization GO:0030199 9.33 COL1A2 COL3A1 LOX
5 response to fluid shear stress GO:0034405 9.32 NOS3 PKD1
6 blood vessel development GO:0001568 9.26 COL1A2 COL3A1 LOX PKD1
7 extracellular matrix organization GO:0030198 9.1 COL1A2 COL3A1 ELN FBN2 LOX VCAN

Molecular functions related to Intracranial Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glycosaminoglycan binding GO:0005539 9.16 ENG VCAN
2 extracellular matrix structural constituent GO:0005201 9.02 COL1A2 COL3A1 ELN FBN2 VCAN
3 platelet-derived growth factor binding GO:0048407 8.96 COL1A2 COL3A1

Sources for Intracranial Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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