MCID: INT074
MIFTS: 22

Intracranial Arteriosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Intracranial Arteriosclerosis

MalaCards integrated aliases for Intracranial Arteriosclerosis:

Name: Intracranial Arteriosclerosis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:13097
MeSH 44 D002537
UMLS 70 C0007771

Summaries for Intracranial Arteriosclerosis

MalaCards based summary : Intracranial Arteriosclerosis is related to arteriosclerosis and cerebral atherosclerosis. An important gene associated with Intracranial Arteriosclerosis is MMACHC (Metabolism Of Cobalamin Associated C). The drugs Cilostazol and Metoprolol have been mentioned in the context of this disorder.

Wikipedia : 73 Atherosclerosis is a disease in which the wall of the artery develops abnormalities, called lesions.... more...

Related Diseases for Intracranial Arteriosclerosis

Graphical network of the top 20 diseases related to Intracranial Arteriosclerosis:



Diseases related to Intracranial Arteriosclerosis

Symptoms & Phenotypes for Intracranial Arteriosclerosis

Drugs & Therapeutics for Intracranial Arteriosclerosis

Drugs for Intracranial Arteriosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 101)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
2
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
3
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
4
Propranolol Approved, Investigational Phase 4 525-66-6 4946
5
Atenolol Approved Phase 4 29122-68-7 2249
6
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
7
tannic acid Approved Phase 4 1401-55-4
8
Probucol Approved, Investigational Phase 4 23288-49-5 4912
9
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 4 14838-15-4 26934
10
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
11
Evolocumab Approved Phase 4 1256937-27-5
12 Rosuvastatin Calcium Phase 4 147098-20-2
13 Anti-Asthmatic Agents Phase 4
14 Fibrinolytic Agents Phase 4
15 Respiratory System Agents Phase 4
16 Neuroprotective Agents Phase 4
17 Vasodilator Agents Phase 4
18 Phosphodiesterase 3 Inhibitors Phase 4
19 Bronchodilator Agents Phase 4
20 Phosphodiesterase Inhibitors Phase 4
21 Platelet Aggregation Inhibitors Phase 4
22 Cardiotonic Agents Phase 4
23 Anti-Arrhythmia Agents Phase 4
24 Adrenergic Antagonists Phase 4
25 Adrenergic Agents Phase 4
26 Adrenergic beta-Antagonists Phase 4
27 Angiotensin-Converting Enzyme Inhibitors Phase 4
28 Sympatholytics Phase 4
29 Adrenergic beta-1 Receptor Antagonists Phase 4
30 Protective Agents Phase 4
31 Antioxidants Phase 4
32 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
33 Hormones Phase 4
34 Calcium, Dietary Phase 4
35 Antimetabolites Phase 4
36 Lipid Regulating Agents Phase 4
37 Hypolipidemic Agents Phase 4
38 Anticholesteremic Agents Phase 4
39 Antihypertensive Agents Phase 4
40
Calcium Nutraceutical Phase 4 7440-70-2 271
41
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
42
Nicotinamide Approved, Investigational Phase 3 98-92-0 936
43
Colestipol Approved Phase 3 26658-42-4
44
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
45
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
46 Neurotransmitter Agents Phase 3
47 Analgesics, Non-Narcotic Phase 3
48 Analgesics Phase 3
49 Antirheumatic Agents Phase 3
50 Cyclooxygenase Inhibitors Phase 3

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis - High-Resolution Magnetic Resonance Imaging Study (STAMINA-MRI Study) Unknown status NCT02458755 Phase 4 High-dose statin: Atorvastatin 40mg or Rosuvastatin 20mg
2 Reducing Total Cardiovascular Risk in an Urban Community Completed NCT00241904 Phase 4 Antiplatelet Agents;Beta Blocker;ACE Inhibitors
3 A Randomized, Control, Open Label, Multicentre Clinical Study to Evaluate the Efficacy and Safety of Cilostazol and Probucol Alone and in Combination on Atherosclerosis Related Biomarker---atherosclerosis Cerebral Infarction Patient as Study Subject Completed NCT00823875 Phase 4 Cilostazol group;Probucol group;Cilostazol + Probucol group;control group
4 Multicenter Double-blind Placebo-controlled Parallel-group Randomized Clinical Trial of Efficacy and Safety of Divaza in the Management of Oxidative Disturbances in Cerebral Atherosclerosis Completed NCT03485495 Phase 4 Divaza;Placebo
5 The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques: a Prospective, Random, Single-center Study Based on High Resolution Magnetic Resonance Imaging Recruiting NCT03753555 Phase 4 Atorvastatin Calcium;Atorvastatin Calcium;Probucol
6 Reducing Intracranial atheroSclErosis With Repatha Not yet recruiting NCT04573777 Phase 4 Repatha
7 Multicenter Clinical Trial for Development of Guidelines of Adequate Blood Pressure Lowering in the Subacute Ischemic Stroke Patients Due to Intracranial Atherosclerosis Terminated NCT01104311 Phase 4
8 Study of Urinary Kallikrein to Enhance Collateral Circulation in Symptomatic Intracranial Atherosclerosis: a Study Based on Whole-brain CTP Withdrawn NCT04325932 Phase 4 Urinary Kallikrein
9 The Impact of Repeated Bilateral Limb Remote Ischemic Conditioning on Patients With Chronic Cerebral Ischemia: Establishment of Optimized Algorithm on the Basis of Feasibility, Safety and Efficacy Unknown status NCT03105141 Phase 2, Phase 3
10 Angioplasty and Stenting for Patients With Symptomatic Intracranial Atherosclerosis: Study Protocol of a Randomized Controlled Trial Unknown status NCT02689037 Phase 3 Aspirin plus clopidogrel
11 Cilostazol-Aspirin Therapy Against Recurrent Stroke With Intracranial Artery Stenosis (CATHARSIS) Completed NCT00333164 Phase 3 Asprin, Cilostazol
12 Cholesterol-Lowering Atherosclerosis Study (CLAS) Completed NCT00000599 Phase 3 colestipol;niacin
13 Prevention for the Restenosis of Intracranial Artery Stent Implantation Treated With Herbal Medicine C117--PRISIT Trial Unknown status NCT03008798 Phase 2 Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
14 Asymptomatic Carotid Artery Plaque Study (ACAPS) Completed NCT00000469 Phase 2 aspirin;lovastatin
15 Antioxidants and Prevention of Early Atherosclerosis Terminated NCT00000600 Phase 2 Vitamin E;Vitamin C
16 A Single/Multiple Ascending Dose Phase 1 Study of the Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Human Volunteers Completed NCT04103034 Phase 1 BT200;Desmopressin;Placebo
17 Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRI Enrolling by invitation NCT03084523 Phase 1 Ferumoxytol Injectable Product
18 Remote Ischemic Conditioning for Avoiding Recurrence of Ischemic Stroke in Patients With Symptomatic Intracranial Atherosclerotic Stenosis Unknown status NCT02534545
19 Vessel Wall and Perfusion Imaging in Intracranial Atherosclerosis Unknown status NCT02719652
20 Clinical Trail of Hybrid Operating Technique in Management of Intracranial Aneurysms With Coexistence of Atherosclerotic Intracranial Arterial Stenosis Unknown status NCT03204435
21 Wingspan Stenting for Symptomatic Severe Stenosis of Intracranial Atherosclerosis Registry in China Unknown status NCT00685308
22 Boston Scientific EPI: A Carotid Stenting Trial for High-Risk Surgical Patients Completed NCT00316108
23 Intracranial Atherosclerosis and Predictors of Post-CABG Depression Completed NCT01838356
24 Identification of the Antiplatelet Compounds of Garlic Ex Vivo Completed NCT00200785
25 EDAS (Surgical) Revascularization for Symptomatic Intracranial Arterial Stenosis Completed NCT01819597
26 Stroke Imaging Package Study Completed NCT02485275
27 Epidemiology of Vascular Inflammation & Atherosclerosis Completed NCT00087893
28 Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC Completed NCT00064545
29 An International Registry of the Wingspan™ Stent System for the Treatment of Intracranial Atherosclerotic Stenosis Completed NCT00929383
30 WEAVE™ Trial: Wingspan StEnt System Post MArket SurVEillance Study Completed NCT02034058
31 Pilot Study of Pre-Ischemic Conditioning for Intracranial Atherosclerosis Completed NCT03208166
32 Asymptomatic Intracranial Atherosclerotic Disease: Prevalence, Clinical and Lifestyle Determinants in Urban Pakistan Completed NCT02072876
33 Stroke Imaging Package Study of Intracranial Atherosclerosis Recruiting NCT03719820 aggressive medical management
34 Morphologic Evolution and Remodeling of Intracranial Atherosclerosis: A Longitudinal Study by 3D-rotational Angiography Recruiting NCT03295773
35 CUHK Stroke Biobank Recruiting NCT03291392
36 Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic Potential Recruiting NCT03291652
37 The Role of Additional Antiplatelet Therapy in the Ischemic Stroke With Atrial Fibrillation and Co-morbiD Atherosclerosis During edOxaban treatmeNt. (ADD-ON) Study, Multicenter Registry-based Analysis Recruiting NCT04010955 Edoxaban Monotherapy
38 Vessel Wall MR Imaging to Explore Sex-Differences of Intracranial Arterial Wall Changes After Suspected Stroke Recruiting NCT03990545
39 A Prospective, Multicenter, Randomized Controlled Clinical Trial to Evaluate the Efficacy and Safety of Intracranial Drug-coated Balloon Catheters in the Treatment of Symptomatic Intracranial Atherosclerotic de Novo Stenosis Not yet recruiting NCT04631055
40 A Prospective, Multi-center, Randomized Controlled Trial to Evaluate the Safety and Feasibility of Intracranial Drug-coated Balloon Catheter in the Treatment of Intracranial In-stent Restenosis Not yet recruiting NCT04627870
41 Study on Prevention and Treatment of Atherosclerotic Cerebral Occlusive Disease With Remote Ischemic Conditioning Not yet recruiting NCT04470492 Medical Management
42 Evaluation of the Safety and Efficacy of Drug Eluting Balloon Catheter for the Treatment of Patients With Symptomatic Intracranial Atherosclerosis Stenosis Not yet recruiting NCT04821726
43 PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis Terminated NCT03507374 Early Phase 1 Alirocumab;Placebo

Search NIH Clinical Center for Intracranial Arteriosclerosis

Genetic Tests for Intracranial Arteriosclerosis

Anatomical Context for Intracranial Arteriosclerosis

Publications for Intracranial Arteriosclerosis

Articles related to Intracranial Arteriosclerosis:

# Title Authors PMID Year
1
Association between Plasma Adipocytokines Levels and Intracranial versus Extracranial Atherosclerotic among Chinese Patients with Stroke. 61
32548044 2020
2
Correlation between Metabolic Syndrome and Intracranial versus Extracranial Arteriosclerosis among Chinese Patients with Stroke. 61
31970098 2019
3
Intracranial Carotid Artery Calcification Relates to Recanalization and Clinical Outcome After Mechanical Thrombectomy. 61
28008095 2017
4
CD62-mediated activation of platelets in cerebral white matter lesions in patients with cognitive decline. 61
26388436 2016
5
[Endovascular treatment of critical basilar stenosis with a Solitaire® stent device: a first experience in our centre]. 61
25030071 2014
6
Giant aneurysm of the basilar artery in an 86 year old woman. 61
24358886 2013
7
[The study on the correlation of pulse wave velocity and ankle-brachial index to ischemic stroke in patients]. 61
21774223 2011
8
[Diabetes mellitus and intracranial stenosis]. 61
10390765 1999
9
[Various observations on intracranial arteriosclerosis in East Germany]. 61
5122609 1971

Variations for Intracranial Arteriosclerosis

Expression for Intracranial Arteriosclerosis

Search GEO for disease gene expression data for Intracranial Arteriosclerosis.

Pathways for Intracranial Arteriosclerosis

GO Terms for Intracranial Arteriosclerosis

Biological processes related to Intracranial Arteriosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of endopeptidase activity GO:0010951 9.26 SERPINE1 CST4
2 platelet degranulation GO:0002576 9.16 SERPINE1 SELP
3 negative regulation of peptidase activity GO:0010466 8.96 SERPINE1 CST4
4 defense response to Gram-negative bacterium GO:0050829 8.62 SERPINE1 SELP

Molecular functions related to Intracranial Arteriosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase inhibitor activity GO:0030414 8.62 SERPINE1 CST4

Sources for Intracranial Arteriosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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