Intracranial Arteriosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Intracranial Arteriosclerosis

MalaCards integrated aliases for Intracranial Arteriosclerosis:

Name: Intracranial Arteriosclerosis 12 15 73


External Ids:

Disease Ontology 12 DOID:13097
MeSH 44 D002537
UMLS 73 C0007771

Summaries for Intracranial Arteriosclerosis

MalaCards based summary : Intracranial Arteriosclerosis is related to cerebral atherosclerosis. An important gene associated with Intracranial Arteriosclerosis is SELP (Selectin P). The drugs Citalopram and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and testes.

Wikipedia : 76 Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.... more...

Related Diseases for Intracranial Arteriosclerosis

Diseases related to Intracranial Arteriosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cerebral atherosclerosis 11.2

Symptoms & Phenotypes for Intracranial Arteriosclerosis

Drugs & Therapeutics for Intracranial Arteriosclerosis

Drugs for Intracranial Arteriosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 174)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Citalopram Approved Phase 4,Phase 3 59729-33-8 2771
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
Donepezil Approved Phase 4,Phase 3,Phase 1 120014-06-4 3152
Cilostazol Approved, Investigational Phase 4,Phase 3 73963-72-1 2754
Probucol Approved, Investigational Phase 4 23288-49-5 4912
Atenolol Approved Phase 4 29122-68-7 2249
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
Propranolol Approved, Investigational Phase 4 525-66-6 4946
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
Corticosterone Experimental Phase 4 50-22-6 5753
15 Antidepressive Agents Phase 4,Phase 3
16 Antidepressive Agents, Second-Generation Phase 4,Phase 3
17 Antiparkinson Agents Phase 4
18 Autonomic Agents Phase 4,Phase 2,Phase 3
19 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Cholinergic Antagonists Phase 4
21 Muscarinic Antagonists Phase 4
22 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2,Phase 3
24 Parasympatholytics Phase 4
25 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
26 Psychotropic Drugs Phase 4,Phase 3,Phase 2
27 Serotonin Agents Phase 4,Phase 3
28 Serotonin Uptake Inhibitors Phase 4,Phase 3
29 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2
30 Nootropic Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Cholinesterase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
32 Anti-Asthmatic Agents Phase 4,Phase 3
33 Anticholesteremic Agents Phase 4,Phase 2
34 Antimetabolites Phase 4,Phase 3,Phase 2
35 Antioxidants Phase 4,Phase 2
36 Bronchodilator Agents Phase 4,Phase 3
37 Fibrinolytic Agents Phase 4,Phase 3
38 Hypolipidemic Agents Phase 4,Phase 3,Phase 2
39 Lipid Regulating Agents Phase 4,Phase 3,Phase 2
40 Neuroprotective Agents Phase 4,Phase 3
41 Phosphodiesterase 3 Inhibitors Phase 4,Phase 3
42 Platelet Aggregation Inhibitors Phase 4,Phase 3
43 Protective Agents Phase 4,Phase 3,Phase 2
44 Respiratory System Agents Phase 4,Phase 3
45 Vasodilator Agents Phase 4,Phase 3,Phase 2
46 Adrenergic Agents Phase 4,Phase 2
47 Adrenergic Antagonists Phase 4,Phase 2
48 Adrenergic beta-Antagonists Phase 4
49 Angiotensin-Converting Enzyme Inhibitors Phase 4
50 HIV Protease Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 101)
# Name Status NCT ID Phase Drugs
1 Study of Escitalopram Versus Placebo in the Treatment of Depressive Syndrome in Alzheimer’s Disease, Vascular Dementia, and Mixed Vascular and Alzheimer’s Dementia Unknown status NCT00229333 Phase 4 Escitalopram
2 Study of Cilostazol and Probucol Alone and in Combination on Atherosclerosis Related Biomarker---atherosclerosis Cerebral Infarction Patient as Study Subject Completed NCT00823875 Phase 4 Cilostazol group;Probucol group;Cilostazol + Probucol group;control group
3 Reducing Total Cardiovascular Risk in an Urban Community Completed NCT00241904 Phase 4 Antiplatelet Agents;Beta Blocker;ACE Inhibitors
4 A Clinical Trial to Evaluate the Safety and Efficacy of 20 ml Cerebrolysin in Patients With Vascular Dementia Completed NCT00947531 Phase 4 Cerebrolysin;0.9% Saline Solution
5 Cilostazol Verse Asprin for Vascular Dementia in Poststroke Patients With White Matter Lesions Completed NCT00847860 Phase 4 Cilostazol;Aspirin
6 Low-Dose Opiate Therapy for Discomfort in Dementia (L-DOT) Completed NCT00385684 Phase 4 hydrocodone/APAP w placebo PRN;hydrocodone/APAP;placebo with hydrocodone/APAP PRN
7 Efficacy and Safety of Donepezil Hydrochloride (Aricept) in Vascular Dementia Completed NCT00165763 Phase 4 donepezil hydrochloride (Aricept)
8 Clinical Trial of Efficacy and Safety of Divaza in the Management of Oxidative Disturbances in Cerebral Atherosclerosis Recruiting NCT03485495 Phase 4 Divaza;Placebo
9 Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis Recruiting NCT02458755 Phase 4 High-dose statin: Atorvastatin 40mg or Rosuvastatin 20mg
10 Imaging of Brain Amyloid Plaques in the Aging Population Enrolling by invitation NCT00950430 Phase 4 Pittsburgh Compound B (C-11 PiB);F-18 FDG;Tau (18-F-AV-1451)
11 Strategy for Adequate Blood Pressure Lowering in the Patients With Intracranial Atherosclerosis Terminated NCT01104311 Phase 4
12 Efficacy and Safety of Tianzhi Granule in Mild to Moderate Vascular Dementia Unknown status NCT02453932 Phase 3 Tianzhi granule and placebo identified to donepezil;Donepezil and placebo identified to Tianzhi granule;Placebo
13 Symptomatic Treatment of Vascular Cognitive Impairment Unknown status NCT02098824 Phase 2, Phase 3 Galantamine;Methylphenidate;Placebo
14 Evaluating the Effects of Music Interventions on Hospitalised People With Dementia Unknown status NCT00448318 Phase 2, Phase 3
15 Cilostazol-Aspirin Therapy Against Recurrent Stroke With Intracranial Artery Stenosis Completed NCT00333164 Phase 3 Asprin, Cilostazol
16 Cholesterol-Lowering Atherosclerosis Study (CLAS) Completed NCT00000599 Phase 3 colestipol;niacin
17 Seroquel- Agitation Associated With Dementia Completed NCT00621647 Phase 3 Quetiapine Fumarate;Quetiapine Fumarate;Placebo
18 A Study of the Safety and Effectiveness of Galantamine Versus Placebo in the Treatment of Patients With Vascular Dementia or Mixed Dementia Completed NCT00261573 Phase 3 galantamine hydrobromide
19 A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Behavioral Disturbances in Patients With Dementia Completed NCT00253123 Phase 3 risperidone
20 A Study of the Effectiveness and Safety of Risperidone in the Treatment of Behavioral Disturbances in Patients With Dementia Completed NCT00249158 Phase 3 Risperidone
21 A Study of the Effectiveness and Safety of Risperidone in the Treatment of Behavioral Disturbances in Patients With Dementia Completed NCT00249145 Phase 3 risperidone
22 Dopamine Transporter Scintigraphy Imaging (DAT-Imaging) in Patients With Lewy Body Dementia Completed NCT00209456 Phase 3 DatSCAN
23 Donepezil Hydrochloride (E2020) in Dementia Associated With Cerebrovascular Disease Completed NCT00165737 Phase 3 Donepezil Hydrochloride
24 Rivastigmine Capsules in Patients With Probable Vascular Dementia Completed NCT00130338 Phase 3 Rivastigmine
25 Efficacy and Safety of Rivastigmine Capsules in Patients With Probable Vascular Dementia Completed NCT00099216 Phase 3 Rivastigmine
26 A Placebo-controlled Trial to Evaluate the Safety and Efficacy of Galantamine in the Treatment of Vascular Dementia Completed NCT00035191 Phase 3 galantamine
27 Serotonergic Pharmacotherapy for Agitation of Dementia Completed NCT00009204 Phase 3 Citalopram [Celexa];Perphenazine [Trilafon]
28 Optimized Remote Ischemic Conditioning (RIC) Treatment for Patients With Chronic Cerebral Ischemia Recruiting NCT03105141 Phase 2, Phase 3
29 MIND Diet Intervention and Cognitive Decline Active, not recruiting NCT02817074 Phase 3
30 Angioplasty and Stenting for Patients With Symptomatic Intracranial Atherosclerosis Not yet recruiting NCT02689037 Phase 3 Aspirin plus clopidogrel
31 Vaspect Study - An Open-Label Trial Of Donepezil in Vascular and Mixed Dementia Terminated NCT00174382 Phase 3 Donepezil
32 The Clinical Trial of Chinese Herbal Medicine SaiLuoTong Capsule Unknown status NCT01978730 Phase 2 high dose group of SaiLuoTong capsule;low dose group of SaiLuoTong;the control group
33 Efficacy and Safety of Fufangdanshen Tablets in Mild to Moderate Vascular Dementia Unknown status NCT01761227 Phase 2 Fufangdanshen Tablets;Placebo
34 Effect of Zydena (Udenafil) on Cerebral Blood Flow and Peripheral Blood Viscosity Unknown status NCT01466543 Phase 2 Zydena (Udenafil);Placebo
35 Asymptomatic Carotid Artery Plaque Study (ACAPS) Completed NCT00000469 Phase 2 aspirin;lovastatin
36 DAOIB for the Treatment of Cognitive Function and Behavioral and Psychological Symptoms of Dementia Completed NCT02103673 Phase 2 DAOIB;Placebo
37 Effect of Insulin Sensitizer Metformin on AD Biomarkers Completed NCT01965756 Phase 2 Metformin;Placebos
38 Delta-THC in Dementia Completed NCT01608217 Phase 2 delta-9-tetrahydrocannabinol (delta-THC);Placebo;Acetaminophen;Acetaminophen
39 Study of STA-1 Capsule in Patients With Vascular Dementia (Marrow-Sea Deficiency) Completed NCT01475578 Phase 2 STA-1;Ergoloid Mesylates tablet
40 Surgical Indirect Revascularization For Symptomatic Intracranial Arterial Stenosis Recruiting NCT01819597 Phase 2
41 A Study to Evaluate Efficacy and Safety of BAC in Patient With Alzheimer's Disease or Vascular Dementia Recruiting NCT02886494 Phase 2 BAC;Matched placebo
42 Perfusion by Arterial Spin Labelling Following Single Dose Tadalafil in Small Vessel Disease (PASTIS) Trial Active, not recruiting NCT02450253 Phase 2 Tadalafil;Placebo
43 n-3 PUFA for Vascular Cognitive Aging Active, not recruiting NCT01953705 Phase 2 Omega 3 PUFA;Placebo
44 Prevention for the Restenosis of Intracranial Artery Stent Implantation Treated With Herbal Medicine C117 Not yet recruiting NCT03008798 Phase 2 Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
45 A Double-Blind, Placebo-Controlled Safety and Efficacy Study of NA-831 Not yet recruiting NCT03538522 Phase 2 N-831(Traneurocin) 10 mg QD;NA-831 (Traneurocin) 20 mg QD;NA-831 (Traneurocin) 40 mg QD;Placebo oral capsule QD
46 Efficacy and Safety of TMBCZG in Mild to Moderate Vascular Dementia Not yet recruiting NCT03230071 Phase 2 TMBCZG
47 BAC in Patient With Alzheimer's Disease or Vascular Dementia Not yet recruiting NCT02467413 Phase 2 BAC
48 Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-Up Terminated NCT00000600 Phase 2 Vitamin E;Vitamin C
49 Aricept to Improve Functional Tasks in Vascular Dementia Unknown status NCT00457769 Phase 1 Donepezil;Donepezil
50 Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRI Enrolling by invitation NCT03084523 Phase 1 Ferumoxytol Injectable Product

Search NIH Clinical Center for Intracranial Arteriosclerosis

Genetic Tests for Intracranial Arteriosclerosis

Anatomical Context for Intracranial Arteriosclerosis

MalaCards organs/tissues related to Intracranial Arteriosclerosis:

Kidney, Brain, Testes

Publications for Intracranial Arteriosclerosis

Variations for Intracranial Arteriosclerosis

Expression for Intracranial Arteriosclerosis

Search GEO for disease gene expression data for Intracranial Arteriosclerosis.

Pathways for Intracranial Arteriosclerosis

GO Terms for Intracranial Arteriosclerosis

Sources for Intracranial Arteriosclerosis

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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