MCID: INT033
MIFTS: 24

Intracranial Chondrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Intracranial Chondrosarcoma

MalaCards integrated aliases for Intracranial Chondrosarcoma:

Name: Intracranial Chondrosarcoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:7903
NCIt 50 C5462
UMLS 73 C1334238

Summaries for Intracranial Chondrosarcoma

MalaCards based summary : Intracranial Chondrosarcoma is related to chondrosarcoma and multiple enchondromatosis, maffucci type. An important gene associated with Intracranial Chondrosarcoma is IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic), and among its related pathways/superpathways are Citrate cycle (TCA cycle) and Peroxisome. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Intracranial Chondrosarcoma

Diseases related to Intracranial Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 30.3 IDH1 IDH2
2 multiple enchondromatosis, maffucci type 29.8 IDH1 IDH2
3 interval angle-closure glaucoma 10.2 IDH1 IDH2
4 adult oligodendroglioma 10.2 IDH1 IDH2
5 enchondroma 10.2 IDH1 IDH2
6 cytogenetically normal acute myeloid leukemia 10.2 IDH1 IDH2
7 chondroblastic osteosarcoma 10.2 IDH1 IDH2
8 intraductal papilloma 10.1 IDH1 IDH2
9 pilocytic astrocytoma of cerebellum 10.1 IDH1 IDH2
10 spindle cell hemangioma 10.1 IDH1 IDH2
11 periosteal chondrosarcoma 10.1 IDH1 IDH2
12 adult astrocytic tumour 10.1 IDH1 IDH2
13 undifferentiated pleomorphic sarcoma 10.1 IDH1 IDH2
14 drug-induced mental disorder 10.1 IDH1 IDH2
15 drug psychosis 10.1 IDH1 IDH2
16 diffuse infiltrative lymphocytosis syndrome 10.1 IDH1 IDH2
17 2-hydroxyglutaric aciduria 10.1 IDH1 IDH2
18 breast papillary carcinoma 10.1 IDH1 IDH2
19 d-2-hydroxyglutaric aciduria 1 10.1 IDH1 IDH2
20 enchondromatosis, multiple, ollier type 10.1 IDH1 IDH2
21 mucoepidermoid esophageal carcinoma 9.9 CEACAM5 TP53
22 cerebellar astrocytoma 9.9 IDH1 TP53
23 gallbladder squamous cell carcinoma 9.9 CEACAM5 TP53
24 malignant spiradenoma 9.9 CEACAM5 TP53
25 atypical follicular adenoma 9.9 CEACAM5 TP53
26 mixed glioma 9.9 IDH1 TP53
27 periosteal osteogenic sarcoma 9.9 IDH1 TP53
28 biliary papillomatosis 9.9 CEACAM5 TP53
29 pleomorphic xanthoastrocytoma 9.9 IDH1 TP53
30 gliomatosis cerebri 9.9 IDH1 TP53
31 prostate squamous cell carcinoma 9.9 CEACAM5 TP53
32 spinal cord astrocytoma 9.9 IDH1 TP53
33 ovary adenocarcinoma 9.9 CEACAM5 TP53
34 xanthogranulomatous cholecystitis 9.8 CEACAM5 TP53
35 papillary adenocarcinoma 9.8 CEACAM5 TP53
36 adult medulloblastoma 9.8 IDH1 TP53
37 gastrointestinal system benign neoplasm 9.8 CEACAM5 TP53
38 intestinal benign neoplasm 9.8 CEACAM5 TP53
39 giant cell glioblastoma 9.8 IDH1 TP53
40 protoplasmic astrocytoma 9.8 IDH2 TP53
41 ovarian cancer 1 9.8 CEACAM5 TP53
42 malignant ovarian surface epithelial-stromal neoplasm 9.8 CEACAM5 TP53
43 ovary epithelial cancer 9.8 CEACAM5 TP53
44 organ system benign neoplasm 9.8 CEACAM5 TP53
45 integumentary system cancer 9.8 CEACAM5 TP53
46 cystadenocarcinoma 9.8 CEACAM5 TP53
47 cell type benign neoplasm 9.8 CEACAM5 TP53
48 suppression of tumorigenicity 12 9.8 IDH1 TP53
49 colorectal adenocarcinoma 9.7 CEACAM5 TP53
50 female reproductive organ cancer 9.7 CEACAM5 TP53

Graphical network of the top 20 diseases related to Intracranial Chondrosarcoma:



Diseases related to Intracranial Chondrosarcoma

Symptoms & Phenotypes for Intracranial Chondrosarcoma

GenomeRNAi Phenotypes related to Intracranial Chondrosarcoma according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.5 TP53
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.5 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.5 IDH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.5 TP53
5 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.5 IDH1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.5 IDH1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.5 IDH1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.5 TP53
9 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.5 IDH1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.5 TP53
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.5 TP53
12 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.5 TP53
13 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.5 TP53 IDH1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.5 IDH1

Drugs & Therapeutics for Intracranial Chondrosarcoma

Search Clinical Trials , NIH Clinical Center for Intracranial Chondrosarcoma

Genetic Tests for Intracranial Chondrosarcoma

Anatomical Context for Intracranial Chondrosarcoma

Publications for Intracranial Chondrosarcoma

Articles related to Intracranial Chondrosarcoma:

(show all 24)
# Title Authors Year
1
Intracranial chondrosarcoma: Series of three cases with varied and unusual presentations. ( 29676384 )
2018
2
Classical intracranial chondrosarcoma: A case report. ( 27895770 )
2016
3
Maffucci syndrome and intracranial chondrosarcomas: a case report featuring spontaneous resolution of sixth nerve palsy. ( 24978479 )
2015
4
Rare case of a primary intracranial chondrosarcoma. ( 25667469 )
2015
5
Sphenoidal intracranial chondrosarcoma. ( 24717999 )
2014
6
High-grade intracranial chondrosarcoma presenting with haemorrhage. ( 23746570 )
2013
7
Frequent IDH1/2 mutations in intracranial chondrosarcoma: a possible diagnostic clue for its differentiation from chordoma. ( 22323113 )
2012
8
Stereotactic radiosurgery for intracranial chondrosarcoma. ( 22492245 )
2012
9
Intracranial chondrosarcoma: a case report and review of the literature. ( 20077365 )
2009
10
A systematic review of intracranial chondrosarcoma and survival. ( 19796952 )
2009
11
Maffucci's syndrome complicated by intracranial chondrosarcoma: two new illustrative cases. ( 17952287 )
2007
12
Intracranial chondrosarcoma: a case report and review of the literature. ( 15174519 )
2004
13
Primary intracranial chondrosarcoma--a case report. ( 11217275 )
2000
14
Intracranial chondrosarcoma: review of the literature and report of 15 cases. ( 9667567 )
1998
15
Maffucci's Syndrome and Intracranial Chondrosarcoma. ( 17171008 )
1997
16
Intracranial chondrosarcoma. ( 9088376 )
1997
17
Intracranial chondrosarcoma. ( 8585986 )
1995
18
Intracranial chondrosarcoma in a patient with Ollier's disease. ( 1873666 )
1991
19
Intracranial chondrosarcoma--case report. ( 1696697 )
1990
20
Primary intracranial chondrosarcoma: a report of two cases. ( 4047363 )
1985
21
Primary cranial and intracranial chondrosarcoma. A survey. ( 3911744 )
1985
22
Maffucci's syndrome complicated by an intracranial chondrosarcoma and a carotid body tumor. Case report. ( 7264742 )
1981
23
Intracranial chondrosarcoma with extracranial metastases. Case report. ( 5030407 )
1972
24
Dyschondroplasia with haemangiomata (Maffucci's syndrome); report of a case complicated by intracranial chondrosarcoma. ( 14778857 )
1950

Variations for Intracranial Chondrosarcoma

Expression for Intracranial Chondrosarcoma

Search GEO for disease gene expression data for Intracranial Chondrosarcoma.

Pathways for Intracranial Chondrosarcoma

Pathways related to Intracranial Chondrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.27 IDH1 IDH2
2 11.07 IDH1 IDH2
3 10.77 IDH1 TP53
4
Show member pathways
9.74 IDH1 IDH2

GO Terms for Intracranial Chondrosarcoma

Cellular components related to Intracranial Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisome GO:0005777 8.62 IDH1 IDH2

Biological processes related to Intracranial Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.26 IDH1 IDH2
2 2-oxoglutarate metabolic process GO:0006103 9.16 IDH1 IDH2
3 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
4 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Intracranial Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 CEACAM5 IDH1 TP53
2 NAD binding GO:0051287 9.26 IDH1 IDH2
3 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH1 IDH2
4 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2
5 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH1 IDH2

Sources for Intracranial Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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