MCID: INT033
MIFTS: 24

Intracranial Chondrosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Intracranial Chondrosarcoma

MalaCards integrated aliases for Intracranial Chondrosarcoma:

Name: Intracranial Chondrosarcoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:7903
NCIt 50 C5462
UMLS 70 C1334238

Summaries for Intracranial Chondrosarcoma

MalaCards based summary : Intracranial Chondrosarcoma is related to chondrosarcoma and enchondroma. An important gene associated with Intracranial Chondrosarcoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), and among its related pathways/superpathways are Carbon metabolism and Peroxisome. Affiliated tissues include pituitary and pancreas, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Intracranial Chondrosarcoma

Diseases related to Intracranial Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 30.7 TAF15 IDH2 IDH1
2 enchondroma 10.2 IDH2 IDH1
3 adult brain stem glioma 10.1 IDH2 IDH1
4 brain stem glioma 10.1 IDH2 IDH1
5 cytogenetically normal acute myeloid leukemia 10.1 IDH2 IDH1
6 periosteal chondrosarcoma 10.1 IDH2 IDH1
7 adult oligodendroglioma 10.1 IDH2 IDH1
8 childhood oligodendroglioma 10.1 IDH2 IDH1
9 gemistocytic astrocytoma 10.1 IDH2 IDH1
10 adult astrocytic tumour 10.1 IDH2 IDH1
11 mixed oligodendroglioma-astrocytoma 10.1 IDH2 IDH1
12 mixed glioma 10.1 IDH2 IDH1
13 chondroblastic osteosarcoma 10.1 IDH2 IDH1
14 chordoma 10.1
15 low grade glioma 10.1 IDH2 IDH1
16 spindle cell hemangioma 10.1 IDH2 IDH1
17 l-2-hydroxyglutaric aciduria 10.1 IDH2 IDH1
18 enchondromatosis, multiple, ollier type 10.1 IDH2 IDH1
19 diffuse astrocytoma 10.1 IDH2 IDH1
20 childhood acute myeloid leukemia 10.0 IDH2 IDH1
21 brain glioma 10.0 IDH2 IDH1
22 bile duct adenocarcinoma 10.0 IDH2 IDH1
23 giant cell glioblastoma 10.0 IDH2 IDH1
24 combined d-2- and l-2-hydroxyglutaric aciduria 10.0 IDH2 ADHFE1
25 bone sarcoma 9.9 IDH2 IDH1
26 familial isolated hypoparathyroidism 9.9 OGFOD1 JMJD4
27 intrahepatic cholangiocarcinoma 9.9 IDH2 IDH1
28 rheumatoid arthritis 9.9
29 hemangiopericytoma, malignant 9.9
30 3-methylglutaconic aciduria, type iii 9.9
31 leukemia, acute myeloid 9.9
32 lymphoma 9.9
33 hemangioma 9.9
34 chondroma 9.9
35 craniopharyngioma 9.9
36 chondroid chordoma 9.9
37 arthritis 9.9
38 osteochondroma 9.9
39 posttransplant acute limbic encephalitis 9.9
40 adult hepatocellular carcinoma 9.8 IDH2 IDH1
41 juxtacortical chondroma 9.7 IDH3G IDH2 IDH1
42 d-2-hydroxyglutaric aciduria 2 9.6 IDH3G IDH2 ADHFE1
43 multiple enchondromatosis, maffucci type 9.4 IDH3G IDH2 IDH1 ADHFE1
44 d-2-hydroxyglutaric aciduria 1 9.4 IDH3G IDH2 IDH1 ADHFE1
45 2-hydroxyglutaric aciduria 9.4 IDH3G IDH2 IDH1 ADHFE1

Graphical network of the top 20 diseases related to Intracranial Chondrosarcoma:



Diseases related to Intracranial Chondrosarcoma

Symptoms & Phenotypes for Intracranial Chondrosarcoma

GenomeRNAi Phenotypes related to Intracranial Chondrosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-136 8.92 OGFOD1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 8.92 IDH1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-149 8.92 OGFOD1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-47 8.92 IDH1

Drugs & Therapeutics for Intracranial Chondrosarcoma

Search Clinical Trials , NIH Clinical Center for Intracranial Chondrosarcoma

Genetic Tests for Intracranial Chondrosarcoma

Anatomical Context for Intracranial Chondrosarcoma

MalaCards organs/tissues related to Intracranial Chondrosarcoma:

40
Pituitary, Pancreas

Publications for Intracranial Chondrosarcoma

Articles related to Intracranial Chondrosarcoma:

(show all 47)
# Title Authors PMID Year
1
Rituximab as a treatment option in a patient with rheumatoid arthritis and a history of malignancy-intracranial chondrosarcoma/osteochondroma-case based review. 61
33001390 2021
2
Skull Base Chondrosarcoma Caused by Ollier Disease: A Case Report and Literature Review. 61
30872199 2019
3
The Differences Between Intracranial Mesenchymal Chondrosarcoma and Conventional Chondrosarcoma in Clinical Features and Outcomes. 61
30415056 2019
4
Metastasis from Intracranial Mesenchymal Chondrosarcoma: Report of a Rare Case. 61
29972855 2019
5
Intracranial Nonskull-Based Chondrosarcoma Arising from the Sagittal Sinus: A Case Report and Review of the Literature. 61
30205213 2018
6
Distinguishing Falcine Chondrosarcomas from Their Mimics and Management. 61
30257291 2018
7
Intracranial chondrosarcoma: Series of three cases with varied and unusual presentations. 61
29676384 2018
8
Apparent diffusion coefficient and arterial spin labeling perfusion of conventional chondrosarcoma in the parafalcine region: a case report. 61
29487660 2018
9
Pituitary fossa chondrosarcoma: An unusual cause of a sellar suprasellar mass masquerading as pituitary adenoma. 61
29721355 2018
10
Proposed Treatment Paradigm for Intracranial Chondrosarcomas Based on Multidisciplinary Coordination. 61
29033377 2018
11
Botulinum Toxin Type A Injection for Neuropathic Pain in a Patient With a Brain Tumor: A Case Report. 61
29354587 2017
12
A case of acute subdural hematoma due to bleeding from metastatic chondrosarcoma of the skull. 61
28303203 2017
13
Classical intracranial chondrosarcoma: A case report. 61
27895770 2016
14
Chondroma arising from the spinal dura mater at the thoracic level: A case report with molecular analysis. 61
27461824 2016
15
Skull base chondrosarcoma. 61
26724847 2016
16
Rare case of a primary intracranial chondrosarcoma. 61
25667469 2015
17
Squash Cytology of a Dural-Based High-Grade Chondrosarcoma May Mimic That of Glioblastoma in the Central Nervous System. 61
25997403 2015
18
Sphenoidal intracranial chondrosarcoma. 61
24717999 2014
19
High-grade intracranial chondrosarcoma presenting with haemorrhage. 61
23746570 2013
20
Frequent IDH1/2 mutations in intracranial chondrosarcoma: a possible diagnostic clue for its differentiation from chordoma. 61
22323113 2012
21
Stereotactic radiosurgery for intracranial chondrosarcoma. 61
22492245 2012
22
A systematic review of intracranial chondrosarcoma and survival. 61
19796952 2009
23
Intracranial chondrosarcoma: a case report and review of the literature. 61
20077365 2009
24
Recurrent chondrosarcoma of the right skull base in a patient with Maffucci syndrome. 61
18092846 2008
25
Dendritic cells based immunotherapy of patient with chondrosarcoma--case report. 61
18519233 2008
26
Maffucci's syndrome complicated by intracranial chondrosarcoma: two new illustrative cases. 61
17952287 2007
27
Combination of microsurgery and Gamma Knife surgery for the treatment of intracranial chondrosarcomas. 61
18503325 2006
28
Clinicopathologic features of two rare cases of mesenchymal metastatic tumors in the pancreas: review of the literature. 61
17003653 2006
29
Intracranial chondrosarcoma: a case report and review of the literature. 61
15174519 2004
30
Primary intracerebral mesenchymal chondrosarcoma with rhabdomyosarcomatous differentiation: case report and literature review. 61
11708546 2001
31
Intracranial low-grade chondrosarcoma with hyperostosis of the skull: a case report. 61
11212904 2000
32
Primary intracranial chondrosarcoma--a case report. 61
11217275 2000
33
Intracranial chondrosarcoma: review of the literature and report of 15 cases. 61
9667567 1998
34
Intracranial chondrosarcoma. 61
9088376 1997
35
Maffucci's Syndrome and Intracranial Chondrosarcoma. 61
17171008 1997
36
[Chondrosarcoma of the skull base associated with fatal intratumoral hemorrhage : report of an autopsy case and review of the literature]. 61
8849479 1996
37
Intracranial chondrosarcoma. 61
8585986 1995
38
Intracranial chondrosarcoma in a patient with Ollier's disease. 61
1873666 1991
39
Intracranial chondrosarcoma--case report. 61
1696697 1990
40
[Intracranial chondrosarcoma: report of a case]. 61
3741188 1986
41
Primary intracranial chondrosarcoma: a report of two cases. 61
4047363 1985
42
Primary cranial and intracranial chondrosarcoma. A survey. 61
3911744 1985
43
[Intracranial chondrosarcoma. Report of two cases]. 61
6205287 1984
44
Maffucci's syndrome complicated by an intracranial chondrosarcoma and a carotid body tumor. Case report. 61
7264742 1981
45
Asymptomatic subdural chondrosarcoma. Case report. 61
641560 1978
46
Intracranial chondrosarcoma with extracranial metastases. Case report. 61
5030407 1972
47
Dyschondroplasia with haemangiomata (Maffucci's syndrome); report of a case complicated by intracranial chondrosarcoma. 61
14778857 1950

Variations for Intracranial Chondrosarcoma

Expression for Intracranial Chondrosarcoma

Search GEO for disease gene expression data for Intracranial Chondrosarcoma.

Pathways for Intracranial Chondrosarcoma

GO Terms for Intracranial Chondrosarcoma

Cellular components related to Intracranial Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.26 IDH3G IDH2 IDH1 ADHFE1
2 mitochondrial matrix GO:0005759 8.8 IDH3G IDH2 ADHFE1

Biological processes related to Intracranial Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.43 IDH3G IDH2 IDH1
2 oxidation-reduction process GO:0055114 9.43 OGFOD1 JMJD4 IDH3G IDH2 IDH1 ADHFE1
3 NADP metabolic process GO:0006739 9.4 IDH2 IDH1
4 protein hydroxylation GO:0018126 9.37 OGFOD1 JMJD4
5 2-oxoglutarate metabolic process GO:0006103 9.33 IDH2 IDH1 ADHFE1
6 glyoxylate cycle GO:0006097 9.32 IDH2 IDH1
7 isocitrate metabolic process GO:0006102 8.8 IDH3G IDH2 IDH1

Molecular functions related to Intracranial Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.91 TAF15 OGFOD1 JMJD4 IDH3G IDH2 IDH1
2 oxidoreductase activity GO:0016491 9.65 OGFOD1 JMJD4 IDH2 IDH1 ADHFE1
3 magnesium ion binding GO:0000287 9.61 IDH3G IDH2 IDH1
4 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.5 IDH3G IDH2 IDH1
5 dioxygenase activity GO:0051213 9.46 OGFOD1 JMJD4
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0016706 9.4 OGFOD1 JMJD4
7 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.16 IDH2 IDH1
8 isocitrate dehydrogenase activity GO:0004448 8.96 IDH2 IDH1
9 NAD binding GO:0051287 8.8 IDH3G IDH2 IDH1

Sources for Intracranial Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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