MCID: INT010
MIFTS: 38

Intracranial Embolism

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Intracranial Embolism

MalaCards integrated aliases for Intracranial Embolism:

Name: Intracranial Embolism 12 44 15 73
Cerebral Embolism 12 55 73
Cerebral Embolism with Cerebral Infarction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4372
ICD10 33 I66
ICD9CM 35 434.1
MeSH 44 D020766
SNOMED-CT 68 155402009 75543006

Summaries for Intracranial Embolism

MalaCards based summary : Intracranial Embolism, also known as cerebral embolism, is related to patent foramen ovale and endocarditis. An important gene associated with Intracranial Embolism is PLG (Plasminogen), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Ticlopidine and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Intracranial Embolism

Diseases related to Intracranial Embolism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 patent foramen ovale 29.9 F12 F2 SERPINC1
2 endocarditis 29.8 F2 PLAT SERPINC1
3 cerebrovascular disease 29.1 F12 F2 PLAT
4 thrombophilia due to thrombin defect 28.7 F2 F3 PLAT SERPINC1
5 thrombosis 28.7 F2 F3 PLAT SERPINC1
6 antiphospholipid syndrome 28.5 F2 F3 PLAT SERPINC1
7 arteries, anomalies of 27.9 F2 F3 PLAT PLG SERPINC1
8 marantic endocarditis 27.4 F2 F3 PLAT SERPINC1 SERPINF2
9 pulmonary embolism 27.4 F2 F3 PLAT SERPINC1 SERPINF2
10 ligneous conjunctivitis 10.7 PLAT PLG
11 inferior myocardial infarction 10.7 PLAT PLG
12 fibrinolytic defect 10.7 PLAT SERPINC1
13 central retinal artery occlusion 10.7 PLAT PLG
14 argentine hemorrhagic fever 10.7 PLAT SERPINC1
15 coronary restenosis 10.6 PLAT SERPINC1
16 occlusion precerebral artery 10.6 PLAT PLG
17 posterior myocardial infarction 10.6 PLAT SERPINC1
18 encephalopathy, familial, with neuroserpin inclusion bodies 10.6 PLAT SERPINC1
19 carotid artery dissection 10.6 PLAT PLG
20 dirofilariasis 10.6 PLAT PLG
21 conjugate gaze palsy 10.5 F3 PLG
22 spinal cord infarction 10.5 F2 SERPINC1
23 sudden sensorineural hearing loss 10.5 F2 SERPINC1
24 heparin-induced thrombocytopenia 10.5 F3 SERPINC1
25 blood protein disease 10.5 F2 SERPINC1
26 prothrombin deficiency, congenital 10.5 F2 SERPINC1
27 dysbaric osteonecrosis 10.5 F3 PLG
28 ischemic colitis 10.5 F2 SERPINC1
29 subendocardial myocardial infarction 10.4 F2 SERPINC1
30 sneddon syndrome 10.4 F2 SERPINC1
31 vertebral artery occlusion 10.4 F3 PLG
32 lemierre's syndrome 10.4 F3 PLG
33 retinal artery occlusion 10.4 F2 SERPINC1
34 esophageal varix 10.4 F2 SERPINC1
35 intracranial thrombosis 10.4 F3 SERPINC1
36 antithrombin iii deficiency 10.4 F2 SERPINC1
37 post-thrombotic syndrome 10.4 F2 SERPINC1
38 hypersplenism 10.4 F2 SERPINC1
39 carotid artery thrombosis 10.4 F3 PLAT
40 central retinal vein occlusion 10.4 F2 SERPINC1
41 portal vein thrombosis 10.4 F2 SERPINC1
42 pulmonary immaturity 10.4 F3 SERPINC1
43 retinitis pigmentosa, y-linked 10.4 F2 PLAT
44 cerebritis 10.4
45 acute poststreptococcal glomerulonephritis 10.4 PLG SERPINF2
46 cold urticaria 10.3 SERPINC1 SERPINF2
47 plasminogen activator inhibitor-1 deficiency 10.3 PLAT SERPINF2
48 placental abruption 10.3 F2 SERPINC1
49 protein c deficiency 10.3 F2 SERPINC1
50 venous insufficiency 10.3 F2 PLAT

Comorbidity relations with Intracranial Embolism via Phenotypic Disease Network (PDN): (show all 27)


Acute Cystitis Aortic Valve Disease 1
Benign Essential Hypertension Cerebral Atherosclerosis
Cerebrovascular Disease Chronic Myocardial Ischemia
Cortical Blindness Decubitus Ulcer
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Intracranial Thrombosis
Ischemic Heart Disease Mitral Valve Disease
Mitral Valve Stenosis Peripheral Vascular Disease
Respiratory Failure Rheumatic Heart Disease
Sinoatrial Node Disease Spastic Hemiplegia
Swallowing Disorders Transient Cerebral Ischemia
Tricuspid Valve Disease

Graphical network of the top 20 diseases related to Intracranial Embolism:



Diseases related to Intracranial Embolism

Symptoms & Phenotypes for Intracranial Embolism

MGI Mouse Phenotypes related to Intracranial Embolism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 F2 F3 GIPC1 PLAT PLG SERPINC1
2 homeostasis/metabolism MP:0005376 9.23 F12 F2 F3 GIPC1 PLAT PLG

Drugs & Therapeutics for Intracranial Embolism

Drugs for Intracranial Embolism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ticlopidine Approved Phase 4 55142-85-3 5472
2
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
3
Aspirin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-78-2 2244
4
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
5 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
6 Anticoagulants Phase 4,Phase 3,Phase 2
7 Analgesics Phase 4,Phase 3
8 Neurotransmitter Agents Phase 4,Phase 3
9 Cyclooxygenase Inhibitors Phase 4,Phase 3
10 Analgesics, Non-Narcotic Phase 4,Phase 3
11 Cytochrome P-450 Enzyme Inhibitors Phase 4
12 Peripheral Nervous System Agents Phase 4,Phase 3
13 Platelet Aggregation Inhibitors Phase 4,Phase 3
14 Anti-Inflammatory Agents Phase 4,Phase 3
15 Antipyretics Phase 4,Phase 3
16 Purinergic P2 Receptor Antagonists Phase 4,Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
18 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3
19 Antirheumatic Agents Phase 4,Phase 3
20
Warfarin Approved Phase 3 81-81-2 6691 54678486
21
Heparin Approved, Investigational Phase 2, Phase 3 9005-49-6 772 46507594
22
Dalteparin Approved Phase 2, Phase 3 9005-49-6
23
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
24 Tissue Plasminogen Activator Phase 3,Phase 2,Not Applicable
25 Dabigatran Phase 3
26
protease inhibitors Phase 3
27 Serine Proteinase Inhibitors Phase 3
28 HIV Protease Inhibitors Phase 3
29 Antithrombin III Phase 3
30 Antithrombins Phase 3
31 Plasminogen Phase 2, Phase 3,Not Applicable
32 calcium heparin Phase 2, Phase 3
33 Heparin, Low-Molecular-Weight Phase 2, Phase 3
34 Calcium, Dietary Phase 2, Phase 3
35 Anesthetics Phase 2
36 Estradiol valerate Approved, Investigational, Vet_approved 979-32-8
37
Levonorgestrel Approved, Investigational 797-63-7, 17489-40-6 13109
38
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
39
Ethinyl Estradiol Approved 57-63-6 5991
40
Polyestradiol phosphate Approved 28014-46-2
41 Contraceptive Agents
42 Contraceptives, Oral
43 Contraceptives, Oral, Combined
44 Hormone Antagonists
45 Norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination
46 Norinyl
47 Hormones
48 Hormones, Hormone Substitutes, and Hormone Antagonists
49 Estradiol 17 beta-cypionate
50 Estradiol 3-benzoate

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 Incidence of Acute Cerebrovascular Events Using Either Minimized or Standard Cardiopulmonary Bypass Circuit Unknown status NCT00862160 Phase 4
2 Cerebral Embolic Load in Patients Undergoing Surgical Aortic Valve Replacement: A Comparison of the Conventional With the Minimized Extracorporeal Circulation Technique Using Transcranial Doppler Ultrasound Completed NCT02308566 Phase 4
3 Dual Antiplatelet Therapy Versus Oral Anticoagulation for a Short Time to Prevent Cerebral Embolism After TAVI Recruiting NCT01642134 Phase 4 aspirin+clopidogrel (Duoplavin)
4 Rheoparin-coated Tubing System for Minimized Extracorporeal Circulation (MECC) Active, not recruiting NCT02321917 Phase 4
5 Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion Unknown status NCT00336596 Phase 3
6 Stroke Prevention in Sickle Cell Anemia (STOP 1) Completed NCT00000592 Phase 3
7 Boston Area Anticoagulation Trial for Atrial Fibrillation (BAATAF) Completed NCT00000517 Phase 3 warfarin
8 A Clinical Trial Comparing Efficacy and Safety of Dabigatran Etexilate With Warfarin in Patients With Cerebral Venous and Dural Sinus Thrombosis (RE-SPECT CVT) Completed NCT02913326 Phase 3 Dabigatran etexilate;Warfarin
9 Dual AntiPlatelet Therapies for Prevention of Periinterventional Embolic Events in TAVI Not yet recruiting NCT03001960 Phase 3 Preloading before TAVI;Postloading after TAVI
10 Evaluation of the TriActiv ProGuard System During Carotid Artery Stenting Terminated NCT00395785 Phase 2, Phase 3
11 Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis Terminated NCT01204333 Phase 2, Phase 3 Endovascular thrombolysis;Heparin
12 Autologous Bone Marrow Mononuclear Cell Transplantation for Stroke Patients Completed NCT01028794 Phase 1, Phase 2
13 Prevention for the Restenosis of Intracranial Artery Stent Implantation Treated With Herbal Medicine C117 Not yet recruiting NCT03008798 Phase 2 Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
14 Effect of ARC1779 on Cerebral Microembolism in Patients Undergoing Carotid Endarterectomy Terminated NCT00742612 Phase 2 ARC1779 Injection;Placebo (normal saline)
15 TCD Detection of Gas and Solid Micro-Emboli in Patients Undergoing Coronary Artery Bypass Grafting (CABG): The Influence of Proximal Anastomosis Technique Unknown status NCT00294814 Not Applicable
16 A Registry Study of Shuxuening Injection Used in Hospitals in China Unknown status NCT01752946
17 Surgical Tourniquets and Cerebral Emboli Completed NCT02240732
18 Left Atrial Appendage Closure During Open Heart Surgery Completed NCT02378116 Not Applicable
19 Cerebral Microembolism During Hemodialysis Completed NCT02021045
20 Cerebral Embolism (CE) in Catheter Ablation of Atrial Fibrillation (AF) Completed NCT01361295 Not Applicable
21 Incidence and Severity of Silent and Apparent Cerebral Embolism After Conventional and Minimal-invasive Transfemoral Aortic Valve Replacement Completed NCT00883285
22 Transcranial Doppler (TCD) Ultrasound of Subjects Enrolled in BABY HUG - Ancillary to BABY HUG Completed NCT00059293
23 Randomized Clinical Trial of Polyester vs. Polyurethane Patch for Carotid Endarterectomy Completed NCT02341196 Not Applicable
24 Modern Ultrasound Techniques in the Evaluation of Cerebral Venous Sinuses in Neonates Completed NCT00555932 Not Applicable
25 Study Of Lybrel In Relation To Venous Thromboembolism Completed NCT01297348 90ug levonorgestrel / 20 ug ethinyl estradiol;Oral Contraceptives containing 20 ug of ethinyl estradiol
26 Impact of Cranioplasty On Cerebral Perfusion Completed NCT01113645
27 Electrical Cardioversion of Recent Onset Atrial Fibrillation - Silent Thromboembolic Events, Reverse Atrial Remodeling Recruiting NCT02955004
28 Evaluation of Cerebral Thrombembolism After TAVR Recruiting NCT02758964
29 Neurological Monitoring During Extracorporeal Membrane Oxygenation Recruiting NCT02020759
30 Magnetically Enhanced Diffusion for Acute Ischaemic Stroke (MEDIS) Trial Recruiting NCT03098732 Not Applicable
31 Cerebral Microembolism in the Critically Ill With Acute Kidney Injury Recruiting NCT02621749 Not Applicable
32 Thrombolysis and RIPC in Acute Ischemic Stroke Recruiting NCT03218293 Not Applicable
33 Stroke and Cerebrovascular Diseases Registry Recruiting NCT03281590
34 Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment Scales Recruiting NCT03273179

Search NIH Clinical Center for Intracranial Embolism

Cochrane evidence based reviews: intracranial embolism

Genetic Tests for Intracranial Embolism

Anatomical Context for Intracranial Embolism

MalaCards organs/tissues related to Intracranial Embolism:

41
Kidney, Heart, Bone, Bone Marrow

Publications for Intracranial Embolism

Articles related to Intracranial Embolism:

# Title Authors Year
1
Intracranial embolism characteristics in PFO patients: a comparison between positive and negative PFO by transesophageal echocardiography: the rule of nine. ( 20363000 )
2010
2
Severe paradoxical intracranial embolism and pulmonary emboli during hip hemiarthroplasty. ( 14633765 )
2003

Variations for Intracranial Embolism

Expression for Intracranial Embolism

Search GEO for disease gene expression data for Intracranial Embolism.

Pathways for Intracranial Embolism

Pathways related to Intracranial Embolism according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 F12 F2 F3 PLAT PLG SERPINC1
2
Show member pathways
12.43 F12 F2 F3 SERPINC1
3
Show member pathways
11.99 F2 PLAT PLG
4
Show member pathways
11.7 F12 F2 F3 PLAT PLG SERPINC1
5 11.31 F12 F2 F3 PLAT PLG SERPINC1
6 11.23 F12 PLAT PLG
7 11.18 PLAT PLG
8 10.99 F2 GIPC1 PLG
9 10.82 PLAT PLG
10 10.76 F2 PLG
11 10.45 PLAT PLG SERPINF2

GO Terms for Intracranial Embolism

Cellular components related to Intracranial Embolism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 F12 F2 F3 PLAT PLG SERPINC1
2 cell surface GO:0009986 9.62 F3 PLAT PLG SERPINF2
3 extracellular space GO:0005615 9.5 F12 F2 F3 PLAT PLG SERPINC1
4 blood microparticle GO:0072562 9.46 F2 PLG SERPINC1 SERPINF2
5 extracellular exosome GO:0070062 9.28 F12 F2 F3 GIPC1 PLAT PLG

Biological processes related to Intracranial Embolism according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.83 F12 F2 PLAT PLG
2 cellular protein metabolic process GO:0044267 9.67 F2 PLG SERPINC1
3 blood coagulation GO:0007596 9.63 F12 F2 F3 PLAT PLG SERPINC1
4 acute-phase response GO:0006953 9.51 F2 SERPINF2
5 regulation of blood coagulation GO:0030193 9.5 F12 F2 SERPINC1
6 positive regulation of collagen biosynthetic process GO:0032967 9.48 F2 SERPINF2
7 negative regulation of proteolysis GO:0045861 9.46 F2 PLAT
8 blood coagulation, intrinsic pathway GO:0007597 9.43 F12 F2
9 negative regulation of fibrinolysis GO:0051918 9.43 F2 PLG SERPINF2
10 positive regulation of blood coagulation GO:0030194 9.4 F12 F2
11 positive regulation of fibrinolysis GO:0051919 9.37 F12 PLG
12 hemostasis GO:0007599 9.35 F12 F2 F3 PLG SERPINC1
13 fibrinolysis GO:0042730 9.02 F12 F2 PLAT PLG SERPINF2

Molecular functions related to Intracranial Embolism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.62 F12 F2 PLAT PLG
2 signaling receptor binding GO:0005102 9.56 F2 GIPC1 PLAT PLG
3 protease binding GO:0002020 9.33 F3 SERPINC1 SERPINF2
4 serine-type peptidase activity GO:0008236 9.26 F12 F2 PLAT PLG
5 serine-type endopeptidase activity GO:0004252 9.02 F12 F2 F3 PLAT PLG

Sources for Intracranial Embolism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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