MCID: INT010
MIFTS: 48

Intracranial Embolism

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Intracranial Embolism

MalaCards integrated aliases for Intracranial Embolism:

Name: Intracranial Embolism 12 44 15 17 70
Cerebral Embolism 12 54 70
Cerebral Embolism with Cerebral Infarction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4372
ICD9CM 34 434.1
MeSH 44 D020766
SNOMED-CT 67 75543006
ICD10 32 I66
UMLS 70 C0007780 C0752140

Summaries for Intracranial Embolism

MalaCards based summary : Intracranial Embolism, also known as cerebral embolism, is related to nonbacterial thrombotic endocarditis and endocarditis. An important gene associated with Intracranial Embolism is PLG (Plasminogen), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. The drugs Acenocoumarol and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and heart, and related phenotypes are cardiovascular system and cellular

Related Diseases for Intracranial Embolism

Diseases related to Intracranial Embolism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 560)
# Related Disease Score Top Affiliating Genes
1 nonbacterial thrombotic endocarditis 30.4 SERPINC1 PLG F3 F2 CRP
2 endocarditis 30.4 SERPINC1 PLAT F2 CRP ALB
3 thoracic outlet syndrome 30.3 SERPINC1 PLG F2
4 inferior myocardial infarction 30.2 PLG PLAT ACE
5 heparin-induced thrombocytopenia 30.2 SERPINC1 F3
6 carotid stenosis 30.2 VWF SELP CRP ACE
7 basilar artery occlusion 30.1 PLG PLAT F2
8 atrial fibrillation 30.0 VWF SELP PLAT F2 CRP ACE
9 middle cerebral artery infarction 29.9 PLG PLAT
10 polycythemia 29.8 SERPINC1 F2 ACE
11 mitral valve insufficiency 29.8 F2 CRP ALB ACE
12 paroxysmal nocturnal hemoglobinuria 29.8 SERPINC1 SELP F2
13 mitral valve disease 29.8 F3 F2 CRP ACE
14 brain edema 29.7 TJP1 PLAT CRP ALB
15 thrombophilia due to thrombin defect 29.6 VWF SERPINC1 PLAT F3 F2
16 migraine with or without aura 1 29.6 PLG F2 CRP ALB ACE
17 varicose veins 29.6 VWF SERPINC1 PLAT F2
18 cerebrovascular disease 29.6 VWF SELP PLAT F2 CRP ACE
19 bronchopneumonia 29.5 F3 CRP ALB
20 facial paralysis 29.5 PLG CRP ALB ACE
21 hypertensive encephalopathy 29.5 F2 ALB ACE
22 arteriosclerosis 29.3 SERPINC1 SELP F3 CRP ACE
23 mitral valve stenosis 29.3 VWF SERPINC1 SELP PLG F3 F2
24 intracranial thrombosis 29.2 VWF SERPINC1 SELP PLG PLAT F3
25 heart valve disease 29.2 VWF F2 CRP ALB ACE
26 peritonitis 29.2 SELP F2 CRP ALB
27 lung disease 29.2 F3 CRP ALB ACE
28 splenic infarction 29.2 SERPINC1 F3 F2 CRP ALB
29 exanthem 29.1 F3 F2 CRP ALB ACE
30 respiratory failure 29.1 F3 F2 CRP ALB ACE
31 aortic valve insufficiency 29.0 VWF F3 F2 CRP ALB ACE
32 atrial heart septal defect 29.0 SERPINC1 PLG PLAT F3 F2 CRP
33 moyamoya disease 1 29.0 VWF SERPINC1 PLG PLAT F3 F2
34 thrombosis 28.9 VWF SERPINF2 SERPINC1 SELP PLG PLAT
35 coronary thrombosis 28.8 VWF SERPINC1 SELP PLG PLAT F3
36 antiphospholipid syndrome 28.8 VWF SERPINC1 SELP PLAT F3 F2
37 atherosclerosis susceptibility 28.7 VWF SELP F3 CRP ALB ACE
38 disseminated intravascular coagulation 28.7 VWF SERPINF2 SERPINC1 PLG PLAT F3
39 cardiac tamponade 28.7 PLG PLAT F3 F2 CRP ALB
40 thrombophilia 28.6 VWF SERPINF2 SERPINC1 SELP PLAT F3
41 thrombocytosis 28.4 VWF SERPINC1 SELP F3 F2 CRP
42 acute myocardial infarction 28.3 VWF SERPINF2 SERPINC1 SELP PLG PLAT
43 systemic lupus erythematosus 28.2 VWF SELP F3 F2 CRP ALB
44 heart disease 28.2 VWF SERPINC1 SELP PLAT F3 F2
45 nephrotic syndrome 28.2 SERPINF2 SERPINC1 PLG F3 F2 CRP
46 patent foramen ovale 28.1 VWF SERPINC1 PLG PLAT F3 F2
47 pulmonary hypertension 28.0 VWF SERPINC1 SELP PLG PLAT F3
48 thrombocytopenia 28.0 VWF SERPINC1 SELP PLG PLAT F3
49 vascular disease 27.9 VWF SERPINC1 SELP PLG PLAT F3
50 thrombophlebitis 27.8 VWF SERPINF2 SERPINC1 PLG PLAT F3

Comorbidity relations with Intracranial Embolism via Phenotypic Disease Network (PDN): (show all 25)


Acute Cystitis Aortic Valve Disease 1
Benign Essential Hypertension Cerebral Atherosclerosis
Cerebrovascular Disease Cortical Blindness
Decubitus Ulcer Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypothyroidism Intermediate Coronary Syndrome
Intracranial Thrombosis Mitral Valve Disease
Mitral Valve Stenosis Peripheral Vascular Disease
Respiratory Failure Rheumatic Heart Disease
Sinoatrial Node Disease Spastic Hemiplegia
Swallowing Disorders Transient Cerebral Ischemia
Tricuspid Valve Disease

Graphical network of the top 20 diseases related to Intracranial Embolism:



Diseases related to Intracranial Embolism

Symptoms & Phenotypes for Intracranial Embolism

MGI Mouse Phenotypes related to Intracranial Embolism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 ACE ALB CRP F2 F3 KLHDC2
2 cellular MP:0005384 10.07 ALB F2 F3 PLAT PLG SELP
3 homeostasis/metabolism MP:0005376 10.07 ACE ALB CRP F2 F3 OCLN
4 growth/size/body region MP:0005378 10.06 ACE F2 F3 KLHDC2 OCLN PLAT
5 immune system MP:0005387 9.93 ACE ALB CRP F2 F3 KLHDC2
6 mortality/aging MP:0010768 9.73 ACE ALB F2 F3 KLHDC2 PLAT
7 nervous system MP:0003631 9.36 ACE F2 F3 OCLN PLAT PLG

Drugs & Therapeutics for Intracranial Embolism

Drugs for Intracranial Embolism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
2
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
3
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
4
Edoxaban Approved Phase 4 480449-70-5
5
Dabigatran Investigational Phase 4 211914-51-1
6 Neurotransmitter Agents Phase 4
7 Analgesics, Non-Narcotic Phase 4
8 Analgesics Phase 4
9 Antirheumatic Agents Phase 4
10 Purinergic P2Y Receptor Antagonists Phase 4
11 Cyclooxygenase Inhibitors Phase 4
12 Anti-Inflammatory Agents Phase 4
13 Antipyretics Phase 4
14 Anti-Inflammatory Agents, Non-Steroidal Phase 4
15 Platelet Aggregation Inhibitors Phase 4
16 Anticoagulants Phase 4
17 Serine Proteinase Inhibitors Phase 4
18 Antithrombin III Phase 4
19
protease inhibitors Phase 4
20 Antithrombins Phase 4
21 HIV Protease Inhibitors Phase 4
22
Serine Investigational, Nutraceutical Phase 4 56-45-1 5951
23
Warfarin Approved Phase 3 81-81-2 54678486 6691
24 Fibrinolytic Agents Phase 3
25 Tissue Plasminogen Activator Phase 3
26 Anesthetics Phase 2
27
Heparin Approved, Investigational 9005-49-6 772 9812414
28
Atorvastatin Approved 134523-00-5 60823
29 Pharmaceutical Solutions
30 calcium heparin
31 Plasminogen

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Acute Cerebrovascular Events During Extracorporeal Circulation a Comparison of New Minimized Perfusion Circuit to Standard Cardiopulmonary Bypass Unknown status NCT00862160 Phase 4
2 PHASE IV Study of Dual Antiplatelet Therapy Versus Oral Anticoagulation for a Short Time to Prevent Cerebral Embolism After Percutaneous Aortic Valve Implantation. Multicenter Randomized Clinical Trial Completed NCT01642134 Phase 4 aspirin+clopidogrel (Duoplavin)
3 "Prospective Open Label Randomized Evaluation of Abbreviated Course of Dabigatran Etexilate With tranSesophageal echOcardiography (TEE) Control vs Conventional 3-week coUrse With dabigatraN Etexilate Before Cardioversion: Analysis of MRI-detecteD Cerebral Embolism" (RE-SOUND Study), № 1160.242 Recruiting NCT03975062 Phase 4 dabigatran etexilate
4 a Multicenter, Randomized, Open-label, Active-treatment, Controlled Trial to Compare the Efficacy of NOAC With Edoxaban vs. Dual Antiplatelet Therapy (DAPT) for Prevention of Leaflet Thrombosis (Documented by Cardiac CT Imaging) and Cerebral Embolization (Documented With Brain DW-MRI Imaging) in Patients Without an Absolute Indication for Chronic OAC After Successful TAVR Recruiting NCT03284827 Phase 4 NOAC;DAPT
5 Transcranial Ultrasound Enhanced Thrombolysis (TRUST) Unknown status NCT00336596 Phase 3
6 PROximal Protection VErsus NON-Protection in Carotid Artery Stenting (PROVENON Study) A Randomized Prospective MRI-based Trial. Unknown status NCT01331473 Phase 3
7 Dual AntiPlatelet Therapies for Prevention of Periinterventional Embolic Events in Transcatheter Aortic Valve Implantation (TAVI) Unknown status NCT03001960 Phase 3 Preloading before TAVI;Postloading after TAVI
8 Stroke Prevention in Sickle Cell Anemia (STOP 1) Completed NCT00000592 Phase 3
9 Boston Area Anticoagulation Trial for Atrial Fibrillation (BAATAF) Completed NCT00000517 Phase 3 warfarin
10 Prevention for the Restenosis of Intracranial Artery Stent Implantation Treated With Herbal Medicine C117--PRISIT Trial Unknown status NCT03008798 Phase 2 Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
11 Phase 1/2A Study of Intravenous Autologous Bone Marrow Mononuclear Cell Transplantation for Patients After Cerebral Embolism Completed NCT01028794 Phase 1, Phase 2
12 A Study of the Effect of ARC1779 Injection on Cerebral Microembolism in Patients Undergoing Carotid Endarterectomy Terminated NCT00742612 Phase 2 ARC1779 Injection;Placebo (normal saline)
13 Gas and Solid Brain Microembolization Detected by the EmbodopR TCD System During Proximal Coronary Graft Anastomosis Done With Aortic Cross Clamping, Partial Occlusion or the HeartstringR Device and Their Effect on Neurocognitive Performance After Coronary Bypass Operation Unknown status NCT00294814
14 A Registry Study of Shuxuening (a Chinese Medicine Injection) Used in Hospitals in China Unknown status NCT01752946
15 The Occurrence of Cerebral Embolism (CE) in Catheter Ablation of Atrial Fibrillation (AF) Using Two Different Ablation Catheters Completed NCT01361295
16 Coagulation, Inflammation and Cerebral Embolism Using a Rheoparin-coated Tubing System for Minimized Extracorporeal Circulation (MECC): Differences to the Conventional MECC System Completed NCT02321917
17 Incidence and Severity of Silent and Apparent Cerebral Embolism After Conventional and Minimal-invasive Transfemoral Aortic Valve Replacement Completed NCT00883285
18 Prospective, Randomized, Single Center Study of Atherothrombotic and Thromboembolic Events After Carotid Artery Stenting Using Transfemoral and Transradial Approach Completed NCT02722720
19 TCD Ultrasound of Subjects Enrolled in Baby Hug (Baby TCD) Completed NCT00059293
20 Electrical Cardioversion of Recent Onset Atrial Fibrillation - a Study of Silent Thromboembolic Events, Reverse Atrial Electrical and Functional Remodeling Including Inflammatory, Neurohormonal and Thromboembolic Biomarkers Completed NCT02955004
21 Dynamic Changes of MMP9 Concentration Cross Carotid Endarterectomy Monitoring Particulate Cerebral Embolisation Completed NCT02109120
22 Surgical Tourniquets and Cerebral Emboli Pilot Study Completed NCT02240732
23 Can We Protect the Brain Against Thrombus Embolism by Closing the Left Atrial Appendage During Open Heart Surgery Completed NCT02378116
24 Evaluation of Cerebral Thrombembolism After TAVR Completed NCT02758964
25 Quantity, Quality and Laterality of Cerebral Microembolism During Veno-Venous Hemodialysis. Completed NCT02021045
26 Evaluate Reduction in Asymptomatic Cerebral Embolism Completed NCT01520532
27 A Randomized Evaluation of the TriGuard Embolic Deflection Device to Reduce the Impact of Cerebral Embolic Lesions After Transcatheter Aortic Valve Implantation Completed NCT02536196
28 Operative Strategies to Reduce Cerebral Embolic Events During Coronary Artery Bypass Surgery Completed NCT01502683
29 "Transcranial Doppler Assessment of Cerebral Embolization During Early Anti-thrombotic Therapy After Bioprosthetic Aortic Valve Replacement: Comparison of High-dose Aspirin Versus Warfarin Plus Low-dose Aspirin" Completed NCT00465218
30 Effects of Carotid Stent Design on Cerebral Embolization Completed NCT00830232
31 The Recovery of Nerve Function Deficient of Combined Intravenous Thrombolysis and Remote Ischemic Post-conditioning in Acute Ischemic Stroke. Recruiting NCT03218293
32 Cerebral Microembolism in Interventional Cardiology Procedures Recruiting NCT03802760
33 Cerebral Microembolism in the Critically Ill With Acute Kidney Injury: A Prospective Multi-Center Randomized Controlled Trial Comparing Continuous With Intermittent Renal Replacement Therapy. Recruiting NCT02621749
34 Risk of Asymptomatic Cerebral Embolism During Atrial Fibrillation Ablation Using Smart Touch SF Catheter With Ablation Index Guided High-power Short-duration Strategy Versus Smart Touch Catheter With Standard Settings Evaluated by High-resolution Diffusion-weighted Magnetic Resonance Imaging Technique (REDUCE-IT Study) Recruiting NCT04408716
35 PROTECT TAVI - Prospective Randomized Outcome Study in TAVI Patients Undergoing Periprocedural Embolic Cerebral Protection With the Sentinel™ Device Recruiting NCT02895737
36 PROTECTED TAVR: Stroke PROTECTion With SEntinel During Transcatheter Recruiting NCT04149535
37 European Study Evaluating the EMBLOK Cerebral Embolic Protection System During Transcatheter Aortic Valve Replacement (TAVR) Recruiting NCT03130491
38 Clinical Study of a Novel Transcatheter Anti-embolic Filter (TAF) for Cerebral Protection During Aortic Valve Interventions Not yet recruiting NCT04704258
39 A Prospective International Multicentre Randomised Controlled Single Blind Clinical Investigation of Magnetically Enhanced Diffusion for Acute Ischaemic Stroke (MEDIS) Suspended NCT03098732
40 Effects of Cerebral Protection With Filters vs. Flow Reversal on Cerebral Embolization After Carotid Artery Stenting Terminated NCT01414387

Search NIH Clinical Center for Intracranial Embolism

Cochrane evidence based reviews: intracranial embolism

Genetic Tests for Intracranial Embolism

Anatomical Context for Intracranial Embolism

MalaCards organs/tissues related to Intracranial Embolism:

40
Bone Marrow, Bone, Heart, Brain, Cortex, Liver, Endothelial

Publications for Intracranial Embolism

Articles related to Intracranial Embolism:

(show top 50) (show all 1646)
# Title Authors PMID Year
1
Coagulation-fibrinolysis abnormalities in acute and chronic phases of cerebral thrombosis and embolism. 54 61
2148232 1990
2
Cardiac sources of cerebral embolism in people with migraine. 61
33459433 2021
3
Tumor Cells Detected in Retrieved Thrombus: A Case of Cancer-associated Stroke. 61
33678737 2021
4
[Ischemic Stroke]. 61
33762444 2021
5
Persistent or permanent atrial fibrillation is associated with severe cardioembolic stroke in patients with non-valvular atrial fibrillation. 61
33789684 2021
6
[A case of cerebral embolism caused by atrial fibrillation combined with superior mesenteric artery embolism and hepatic portal vein gas in a short time]. 61
33663178 2021
7
Cerebral Embolism After Transcarotid Transcatheter Aortic Valve Replacement: Factors Associated With Ipsilateral Ischemic Burden. 61
32710845 2021
8
Cerebral Emboli Monitoring Using Transcranial Doppler Ultrasonography in Adults and Children: A Review of the Current Technology and Clinical Applications in the Perioperative and Intensive Care Setting. 61
33764341 2021
9
Bilateral total knee arthroplasty: Simultaneous versus staging in the same or in twice hospitalization. 61
33717897 2021
10
A Case of Cerebral Embolism Associated with Calcified Amorphous Tumor: A Review of Cerebral Infarction Cases. 61
33612675 2021
11
Early neurological deterioration in cardiogenic cerebral embolism due to nonvalvular atrial fibrillation: Predisposing factors and clinical implications. 61
33277821 2021
12
Cardiac sources of cerebral embolism in people with migraine. 61
32979886 2021
13
Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations. 61
33419752 2021
14
Cerebral thromboembolic risk in atrial fibrillation ablation: a direct comparison of vitamin K antagonists versus non-vitamin K-dependent oral anticoagulants. 61
32144677 2021
15
Neurologic complications of nonrheumatic valvular heart disease. 61
33632451 2021
16
[The pathology of the thrombi obtained by endovascular thrombectomy were useful for diagnosis of two cases of cardiogenic cerebral embolism due to infective endocarditis and nonbacterial thrombotic endocarditis]. 61
33229830 2020
17
Left Atrial Spinning Ball Thrombus in a Patient with Cardioembolic Stroke: A Case Report. 61
33022584 2020
18
Screening for coronary artery disease in early surgical treatment of acute aortic valve infective endocarditis. 61
33331646 2020
19
Surgical procedure of segmentectomy as a possible cause of postoperative cerebral embolism: a case report. 61
33317588 2020
20
Left Atrial Myxoma Presenting as Cerebral Embolism. 61
32773155 2020
21
Cerebral embolism due to left atrial myxoma in a patient presenting with chest pain and ST-segment elevation: a case report. 61
33442627 2020
22
Near-infrared spectroscopy carotid plaque characteristics and cerebral embolism in carotid artery stenting using first-generation stent. 61
33283761 2020
23
Is it possible to prevent cerebral embolization by improving the design and technology of carotid stent implantation? 61
33021842 2020
24
Calcified cerebral embolism due to aortic valve calcification. 61
32594373 2020
25
Tic Movement of Thyroid Cartilage as a Cause for Localized Cerebral Embolism: Mimics of Embolic Stroke of Undetermined Source with Non-Stenotic Carotid Plaque. 61
33066905 2020
26
Fungal endocarditis with heart valve replacement and atrial fibrillation posing a treatment challenge: A case report. 61
33235057 2020
27
Left atrial size and risk of recurrent ischemic stroke in cardiogenic cerebral embolism. 61
32783327 2020
28
Surgical Thromboendarterectomy for Free-Floating Thrombus Associated with Cervical Carotid Artery Dissection: A Case Report. 61
32439523 2020
29
Relationship between initial international normalized ratio and prognosis in patients with cardiogenic cerebral embolism. 61
32819136 2020
30
In-Hospital Mechanical Thrombectomy: A Case Report. 61
33505268 2020
31
Comparative outcomes of cefazolin versus antistaphylococcal penicillins in methicillin-susceptible Staphylococcus aureus infective endocarditis: a post hoc analysis of a prospective multicentre French cohort study. 61
32950711 2020
32
Association Between Residential Greenness, Cardiometabolic Disorders, and Cardiovascular Disease Among Adults in China. 61
32955574 2020
33
[Autopsy case of cerebral embolism with lung cancer and atrial fibrillation in which the left atrium may have become an incubator for a tumor embolus]. 61
32779594 2020
34
Cerebral embolism accompanied by remarkable diffusion-weighted imaging reversal in a 10 month-old infant with congenital heart disease. 61
32885055 2020
35
Congestive Heart Failure and Cardiogenic Cerebral Embolism as the First Manifestation of Polymyositis. 61
31166212 2020
36
Late Diagnosis of Multiple Cerebral Aneurysms A Decade after Resection of Cardiac Myxoma. 61
33505294 2020
37
Clinical conundrum: concomitant high-risk pulmonary embolism and acute ischemic stroke. 61
32211984 2020
38
Carotid Endarterectomy Using a Flow-Reversal Technique in the Acute Period: A Novel Approach That May Reduce Intraoperative Cerebral Events. 61
32243906 2020
39
Serum Cystatin C Level as a Biomarker of Aortic Plaque in Patients with an Aortic Arch Aneurysm. 61
32848109 2020
40
Cerebral Microembolism in Intracerebral Hemorrhage: A Prospective Case-Control Study. 61
32770342 2020
41
Cerebral paradoxical embolism associated with patent foramen ovale and idiopathic venous thromboembolism in a 31-year-old patient. 61
32728455 2020
42
Thromboembolism and bleeding risk in atrial fibrillation ablation with uninterrupted anticoagulation between new oral anticoagulants and vitamin K antagonists: insights from an updated meta-analysis. 61
31686297 2020
43
Posterior cerebral artery stroke by reverse flow embolism in thoracic outlet syndrome - a case report. 61
32498705 2020
44
Beyond CHA2DS2-VASc in atrial fibrillation: the atrium and the risk of stroke. 61
32523434 2020
45
Fat embolism syndrome with cerebral fat embolism through a patent foramen ovale: A case report. 61
32541485 2020
46
Evolution, Predictors, and Neurocognitive Effects of Silent Cerebral Embolism During Transcatheter Aortic Valve Replacement. 61
32417094 2020
47
Intravenous thrombolysis for pure pontine infarcts caused by cardiac myxoma: a case report and literature review. 61
31818173 2020
48
Free-floating left ventricular thrombus after rapid improvement of cardiac function related to mechanical hemodynamic support. 61
32547660 2020
49
Intracranial Aneurysms After Intravenous Thrombolysis in Patient with Atrial Myxoma: A Case Study. 61
32220555 2020
50
A Case of Successful Treatment of Cerebral Embolism Using Endovascular Thrombectomy Immediately After Transcatheter Aortic Valve Implantation. 61
31864841 2020

Variations for Intracranial Embolism

Expression for Intracranial Embolism

Search GEO for disease gene expression data for Intracranial Embolism.

Pathways for Intracranial Embolism

GO Terms for Intracranial Embolism

Cellular components related to Intracranial Embolism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 VWF SERPINF2 SERPINC1 PLG PLAT F3
2 extracellular exosome GO:0070062 9.97 VWF SERPINF2 SERPINC1 PLG PLAT F2
3 bicellular tight junction GO:0005923 9.61 TJP2 TJP1 OCLN
4 platelet alpha granule lumen GO:0031093 9.56 VWF SERPINF2 PLG ALB
5 blood microparticle GO:0072562 9.55 SERPINF2 SERPINC1 PLG F2 ALB
6 collagen-containing extracellular matrix GO:0062023 9.5 VWF SERPINF2 SERPINC1 PLG PLAT F3
7 tight junction GO:0070160 9.4 TJP1 OCLN
8 extracellular space GO:0005615 9.36 VWF SERPINF2 SERPINC1 SELP PLG PLAT

Biological processes related to Intracranial Embolism according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.78 SERPINC1 PLG F2 ALB
2 platelet degranulation GO:0002576 9.72 VWF SERPINF2 SELP PLG ALB
3 acute-phase response GO:0006953 9.63 SERPINF2 F2 CRP
4 blood coagulation GO:0007596 9.63 VWF SERPINC1 PLG PLAT F3 F2
5 maintenance of permeability of blood-brain barrier GO:0035633 9.61 TJP2 TJP1 OCLN
6 cell-cell junction organization GO:0045216 9.58 TJP2 TJP1 OCLN
7 blood coagulation, intrinsic pathway GO:0007597 9.55 VWF F2
8 establishment of endothelial intestinal barrier GO:0090557 9.54 TJP2 TJP1
9 negative regulation of fibrinolysis GO:0051918 9.54 SERPINF2 PLG F2
10 regulation of bicellular tight junction assembly GO:2000810 9.52 TJP1 OCLN
11 regulation of blood coagulation GO:0030193 9.51 SERPINC1 F2
12 positive regulation of cell-cell adhesion mediated by cadherin GO:2000049 9.49 TJP1 SERPINF2
13 positive regulation of maintenance of permeability of blood-brain barrier GO:1905605 9.43 TJP2 TJP1 OCLN
14 fibrinolysis GO:0042730 9.26 SERPINF2 PLG PLAT F2
15 hemostasis GO:0007599 9.02 VWF SERPINC1 PLG F3 F2

Molecular functions related to Intracranial Embolism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 VWF TJP2 TJP1 SERPINF2 SERPINC1 SELP
2 chaperone binding GO:0051087 9.33 VWF PLG ALB
3 serine-type endopeptidase activity GO:0004252 9.26 PLG PLAT F3 F2
4 protease binding GO:0002020 8.92 VWF SERPINF2 SERPINC1 F3

Sources for Intracranial Embolism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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