Intracranial Hypertension

Categories: Neuronal diseases

Aliases & Classifications for Intracranial Hypertension

MalaCards integrated aliases for Intracranial Hypertension:

Name: Intracranial Hypertension 12 53 54 6 44 15 17 70
Raised Intracranial Pressure 12


External Ids:

Disease Ontology 12 DOID:9428
MeSH 44 D019586
NCIt 50 C84791
SNOMED-CT 67 155052007
UMLS 70 C0151740

Summaries for Intracranial Hypertension

NINDS : 53 Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating sounds within the head, closely mimic symptoms of large brain tumors.

MalaCards based summary : Intracranial Hypertension, also known as raised intracranial pressure, is related to intracranial hypertension, idiopathic and papilledema, and has symptoms including vomiting, headache and papilledema. An important gene associated with Intracranial Hypertension is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Isotretinoin and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and pituitary, and related phenotypes are homeostasis/metabolism and cardiovascular system

Disease Ontology : 12 A brain disease that is characterized by high pressure inside the skull, the brain tissue and cerebrospinal fluid, has symptom headache, has symptom vomiting, has symptom altered mental status, has symptom papilledema.

Related Diseases for Intracranial Hypertension

Diseases related to Intracranial Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 812)
# Related Disease Score Top Affiliating Genes
1 intracranial hypertension, idiopathic 32.9 SLC12A3 HSD11B1 F2 AQP4 AQP1
2 papilledema 32.0 SERPINC1 F3 F2 AQP4 APOH
3 hydrocephalus 31.5 TNF PRL MTHFR AQP4 AQP1
4 brain edema 31.3 IL1B AQP4 AQP1
5 intracranial hypotension 31.2 SERPINC1 F3 F2
6 cranial nerve palsy 31.0 SERPINC1 PRL AQP4
7 sleep apnea 31.0 TNF SERPINE1 IL1B
8 abducens nerve disease 30.9 SERPINC1 PRL F2 AQP4
9 optic nerve disease 30.9 TNF IL1B AQP4 AQP1
10 migraine with or without aura 1 30.9 TNF PRL MTHFR IL1B F2 APOH
11 obstructive hydrocephalus 30.9 PRL AQP4 AQP1
12 sagittal sinus thrombosis 30.9 SERPINC1 F5 F3 F2
13 hepatic coma 30.9 SERPINC1 F3 F2
14 mastoiditis 30.8 SERPINC1 MTHFR F2
15 lateral sinus thrombosis 30.7 SERPINC1 MTHFR F2
16 pulmonary edema 30.7 TNF SERPINC1 IL1B F2
17 severe pre-eclampsia 30.7 SERPINC1 F5 APOH
18 encephalitis 30.7 TNF IL1B CXCL10 AQP4
19 bacterial meningitis 30.6 TNF IL1B AQP4
20 thrombocytosis 30.6 SERPINC1 IL1B F3 F2
21 thrombosis 30.5 SERPINE1 SERPINC1 MTHFR F9 F5 F3
22 compartment syndrome 30.5 TNF SERPINC1 F3 F2
23 adult respiratory distress syndrome 30.5 TNF SERPINE1 IL1B F5 F2
24 syphilis 30.4 TNF F2 APOH
25 open-angle glaucoma 30.3 TNF SERPINE1 MTHFR IL1B AQP1
26 intracranial sinus thrombosis 30.3 SERPINC1 MTHFR F3 F2
27 apnea, obstructive sleep 30.3 TNF SERPINE1 IL1B
28 eclampsia 30.3 TNF SERPINC1 MTHFR F2
29 myelitis 30.3 TNF MTHFR AQP4 APOH
30 meningococcemia 30.3 SERPINE1 SERPINC1 IL1B F5
31 transient cerebral ischemia 30.3 MTHFR IL1B APOH
32 exanthem 30.2 TNF IL1B F3 F2
33 neuritis 30.2 TNF IL1B CXCL10 AQP4
34 epidural abscess 30.2 F3 F2
35 toxic shock syndrome 30.2 TNF SERPINC1 IL1B F3
36 retinal vascular disease 30.2 TNF MTHFR IL1B
37 nonarteritic anterior ischemic optic neuropathy 30.2 SERPINC1 MTHFR F5 F2 APOH
38 viral encephalitis 30.2 TNF IL1B CXCL10
39 respiratory failure 30.2 TNF IL1B F3 F2 CXCL10
40 syphilitic meningitis 30.2 TNF SERPINC1 APOH
41 purpura 30.2 TNF SERPINC1 F3 F2 APOH
42 transverse myelitis 30.2 TNF AQP4 APOH
43 systemic lupus erythematosus 30.2 TNF SERPINE1 PRL IL1B F3 F2
44 arachnoiditis 30.1 TNF IL1B AQP4
45 thrombophilia 30.1 SERPINE1 SERPINC1 MTHFR F9 F5 F3
46 cerebral artery occlusion 30.1 TNF IL1B AQP4
47 optic neuritis 30.1 TNF IL1B CXCL10 AQP4
48 liver cirrhosis 30.1 TNF SERPINC1 IL1B F3 F2
49 typhoid fever 30.1 TNF IL1B F2
50 hemophilia a 30.1 F9 F5 F3

Graphical network of the top 20 diseases related to Intracranial Hypertension:

Diseases related to Intracranial Hypertension

Symptoms & Phenotypes for Intracranial Hypertension


  • vomiting
  • headache
  • papilledema
  • altered mental status

UMLS symptoms related to Intracranial Hypertension:

bulging fontanelle

MGI Mouse Phenotypes related to Intracranial Hypertension:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.35 ABCC8 APOH AQP1 AQP4 CTNS CXCL10
2 cardiovascular system MP:0005385 10.31 AQP1 AQP4 CXCL10 F2 F3 F5
3 growth/size/body region MP:0005378 10.22 ABCC8 AQP1 AQP4 F2 F3 F5
4 immune system MP:0005387 10.13 AQP1 AQP4 CXCL10 F2 F3 F9
5 integument MP:0010771 9.91 F2 F3 F5 HSD11B1 IL1B MTHFR
6 mortality/aging MP:0010768 9.8 APOH AQP1 AQP4 CXCL10 F2 F3
7 liver/biliary system MP:0005370 9.76 F5 F9 HSD11B1 MTHFR PRL SERPINC1
8 nervous system MP:0003631 9.44 AQP1 AQP4 CXCL10 F2 F3 F5

Drugs & Therapeutics for Intracranial Hypertension

Drugs for Intracranial Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 101)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Isotretinoin Approved Phase 4 4759-48-2 5282379 5538
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
Norepinephrine Approved Phase 4 51-41-2 439260
Cisatracurium Approved Phase 4 96946-41-7 62887
8 Liver Extracts Phase 4
9 Antibiotics, Antitubercular Phase 4
10 Anti-Bacterial Agents Phase 4
11 Neuromuscular Blocking Agents Phase 4
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 2, Phase 3 14838-15-4 26934
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 1302 156391
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3 5284371
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
Rifampicin Approved Phase 3 13292-46-1 5381226 5458213
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
Mannitol Approved, Investigational Phase 3 69-65-8 6251 453
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
Pentobarbital Approved, Investigational, Vet_approved Phase 3 76-74-4 4737
Thiopental Approved, Vet_approved Phase 3 76-75-5 3000715
24 Anti-Infective Agents, Local Phase 2, Phase 3
25 Narcotics Phase 2, Phase 3
26 Fibrinolytic Agents Phase 2, Phase 3
27 Chlorpheniramine, phenylpropanolamine drug combination Phase 2, Phase 3
28 Cyclooxygenase Inhibitors Phase 2, Phase 3
29 Antirheumatic Agents Phase 2, Phase 3
30 Analgesics, Opioid Phase 2, Phase 3
31 Antitussive Agents Phase 2, Phase 3
32 Anti-Inflammatory Agents Phase 2, Phase 3
33 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
34 Antipyretics Phase 2, Phase 3
35 Platelet Aggregation Inhibitors Phase 2, Phase 3
36 Clindamycin palmitate Phase 3
37 Anti-Infective Agents Phase 3
38 Clindamycin phosphate Phase 3
39 diuretics Phase 3
40 Hormones Phase 2, Phase 3
41 Anticonvulsants Phase 3
42 Carbonic Anhydrase Inhibitors Phase 3
43 Anesthetics Phase 3
44 Hypnotics and Sedatives Phase 3
45 Neurotransmitter Agents Phase 3
46 GABA Modulators Phase 3
47 Anesthetics, Intravenous Phase 3
48 Anesthetics, General Phase 3
Angiotensin II Approved, Investigational Phase 2 68521-88-0, 11128-99-7, 4474-91-3 172198
Amlodipine Approved Phase 2 88150-42-9 2162

Interventional clinical trials:

(show top 50) (show all 128)
# Name Status NCT ID Phase Drugs
1 Prospective Open-label Phase IV Trial to Investigate the Frequency of Optic Disc Swelling, Idiopathic Intracranial Hypertension and Dry Eye Symptoms Under Antiacne Medication Treatment Unknown status NCT02149615 Phase 4
2 Equimolar Doses of Mannitol and Hypertonic Saline in the Treatment of Elevated Intracranial Pressure Completed NCT00447018 Phase 4 20% mannitol;7.45% hypertonic saline solution
3 Use of HA 330-II for Hemofiltration in Patients With Acute Liver Failure as a Bridge to Liver Transplantation: Clinical Evaluation Protocol. Recruiting NCT04243655 Phase 4 Standard medical treatment (SMT)
4 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents. A Controlled Randomized Study Versus Placebo Recruiting NCT02404779 Phase 4 cisatracurium besilate
5 Compared Effects of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension Terminated NCT00795587 Phase 4 variation of mannitol dose
6 Scientific Research and Development of Innovative Evidence Based Non-invasive Brain Diagnostic and Monitoring Solutions for Neurological and Traumatic Brain Injury Patients Unknown status NCT02130219 Phase 2, Phase 3
7 Effect of Preventive Sodium Lactate Infusion on Intracranial Hypertension in Severe Trauma Tic Brain Injury Completed NCT00995683 Phase 2, Phase 3 half molar sodium lactate;isotonic sodium chloride
8 Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients Study Protocol for a Multicenter Randomized Open-label Trial With Blinded Adjudication of Primary Outcome Completed NCT03143751 Phase 3 NaCl20% (Continuous hyperosmolar therapy)
9 A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
10 The Impact of Ventricular Catheter Impregnated With Antimicrobial Agents on Infection in Patients With Ventricular Catheter: A Prospective Randomized Study Completed NCT00286104 Phase 3
11 Assessment of the Interest of Intravenous Administration of Molar Sodium Lactate on the Quality of Brain Relaxation for Resection Surgery of Supratentorial Brain Tumors by Craniotomy. Recruiting NCT04488874 Phase 3 Sodium Lactate;Mannitol 20% Infusion
12 The Role of Optic Nerve Sheath Fenestration in Leukemic Patients Having Increased Intracranial Pressure Active, not recruiting NCT04431882 Phase 2, Phase 3
13 Phase II/III, Randomized, Clinical Trial of the Effects of Nutropin AQ® on Growth and Bone Metabolism in Children With MPS I, II, and VI and Short Stature Terminated NCT00748969 Phase 2, Phase 3 Somatropin (DNA origin)
14 Randomized Trial of Medical Therapy (MT) vs. MT Plus Optic Nerve Sheath Fenestration vs. MT Plus Ventriculoperitoneal Cerebrospinal Fluid Shunting in Subjects With Idiopathic Intracranial Hypertension and Moderate to Severe Visual Loss Terminated NCT03501966 Phase 3 Acetazolamide
15 Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension. Terminated NCT00622570 Phase 3 Pentobarbital;thiopental
16 Mannitol Versus Hypertonic Saline to Treat Intracranial Hypertension After Severe Traumatic Brain Injury : a Comparative Study on the Effects on PtiO2 and Microdialysis Values Terminated NCT01028339 Phase 3 Hypertonic saline;Mannitol
17 Sodium-Lactate Versus Mannitol in the Treatment of Intracranial Hypertensive Episodes in Severe Traumatic Brain Injured Patients Terminated NCT00319345 Phase 2, Phase 3 Mannitol, Sodium-Lactate
18 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3 Mannitol;Hypertonic Saline
19 Lowering Intracranial Pressure in Idiopathic Intracranial Hypertension: Assessing the Therapeutic Efficacy and Safety of an 11β-hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017). Phase II Study. Completed NCT02017444 Phase 2 AZD4017
20 Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial) Recruiting NCT03354143 Phase 2 Standard Care;Intensive Treatment
21 Evaluation of the Feasibility, Safety and Efficacy of Venous Stenting for Internal Jugular Vein Stenosis Unknown status NCT03373292 Phase 1
22 Prospective, Randomized Clinical Trialto Compare Mannitol and Hypertonic Saline for Treatment of Increased Intracranial Pressure Unknown status NCT00359697 Phase 1 Hypertonic Saline, Mannitol
23 Venous Sinus Stenting for Idiopathic Intracranial Hypertension Refractory to Medical Therapy Completed NCT01407809 Phase 1
24 Measurement of Optic Nerve Sheath in Traumatic Raised Intracranial Pressure Unknown status NCT00783809
25 Stenting of Venous Sinus Stenosis for Medically Refractory Idiopathic Intracranial Hypertension Unknown status NCT02143258
26 Risk Factors and Common Preventive Measures for Ventilator Associated Pneumonia in Patients With Severe Traumatic Brain Injury Unknown status NCT03266380
27 Validation of a Non-Invasive Intracranial Pressure (ICP) Device by Comparison With Implanted Intracranial Pressure Monitoring Instrumentation or Lumbar Puncture Unknown status NCT03865576
28 Comparison of the Non-invasive ICP HeadSense Monitor vs Lumbar CSF Pressure Measurement Unknown status NCT02773901
29 OCT Imaging of Papilledema in Pediatric Idiopathic Intracranial Hypertension Unknown status NCT02665858
30 Neurocognitive Outcome in Children Who Suffered From Idiopathic Increased Intracranial Hypertension (IIH) Unknown status NCT02857335
31 Magnetic Resonance Venography Pre- and Post-Treatment in Patients With Idiopathic Intracranial Hypertension Unknown status NCT02394067
32 Importance of Substance P in Intracranial Pressure Elevation Following Traumatic Brain Injury Unknown status NCT03035838 Early Phase 1 Fosaprepitant
33 Effect of Ketamine (Ketalar) on Intracranial Pressure Unknown status NCT00437814 Ketamine, effect on intracranial pressure
34 Evaluation of the Intracranial Volume Pressure Relationship in Increased Intracranial Pressure Patients by a Mathematic Manner Unknown status NCT01126658
35 TCD Detection of Ophthalmic Artery Blood Flow Velocity Prediction Feasibility Study of Intracranial Pressure Unknown status NCT02240394
36 Brain Ultrasound in the Weaning of External Ventricular Leads Unknown status NCT03531723
37 Ocular Point of Care Ultrasound (POCUS) to Detect Optic Disc Swelling in Comparison to Ophthalmologic Examination Unknown status NCT02992262
38 Optic Nerve Sheath Diameter Measured by Bedside Ultrasound May be a Simple Screening Test for Increased Intracranial Pressure in the Comatose Critically Ill Patient Unknown status NCT02338284
39 Ultrasonographic Measurement of the Optic Nerve Sheath Diameter and Its Association With Eyeball Transverse Diameter in Robot-assisted Laparoscopic Radical Prostatectomy Unknown status NCT03691025
40 Correlation of Intraocular Pressure With Intracranial Pressure in Childs With Severe Trauma Brain Injury Unknown status NCT03344432
41 Open Study on the Validation of Non-invasive Absolute Intracranial Pressure Monitoring in Patients After Traumatic Brain Injury and Subarachnoid Hemorrhage Unknown status NCT03227354
42 Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment Unknown status NCT03273179
43 Non-invasive Absolute Intracranial Pressure Measurement in Patients With Malignant Middle Cerebral Artery Infarction for Determination of Timing to Decompressive Craniectomy Unknown status NCT03221959
44 Incidence of Intracranial Hypertension During Liver Transplantation Estimated by Non-invasive Ultrasound Methods. Completed NCT02695823
45 Influencing Factors of Intracranial Hypertension in Patients With Bilateral Transverse Sinus Stenosis Completed NCT04492332
46 Spreading Depressions as Secondary Insults After Traumatic Injury to the Human Brain Completed NCT00803036
47 Effect of Intravenous Administration of 20% Mannitol on the Optic Nerve Sheath Diameter(ONSD) in Patients With Raised Intracranial Pressure Completed NCT04188353 Mannitol
48 Role of Hypertonic Saline Versus Mannitol in the Management of Raised Intracranial Pressure in Patients With ALF: A Randomized Open -Label Study Completed NCT02460510 Mannitol;3% hypertonic saline
49 Optic Nerve Sheath Diameter in Retrobulbar Ultrasound as a Surrogate Measure for Intracranial Pressure Before and After Non-invasive Strategies Completed NCT03634176
50 Sonography of the Optic Nerve Sheath Diameter for Detection of Elevated Intracranial Pressure Compared to Computed Tomography Completed NCT03529370

Search NIH Clinical Center for Intracranial Hypertension

Inferred drug relations via UMLS 70 / NDF-RT 51 :

carbamide peroxide
Thiopental Sodium

Cochrane evidence based reviews: intracranial hypertension

Genetic Tests for Intracranial Hypertension

Anatomical Context for Intracranial Hypertension

MalaCards organs/tissues related to Intracranial Hypertension:

Brain, Liver, Pituitary, Pineal, Eye, Spinal Cord, Cerebellum

Publications for Intracranial Hypertension

Articles related to Intracranial Hypertension:

(show top 50) (show all 9843)
# Title Authors PMID Year
Characteristics and operation outcomes of neuro-oncology patients after COVID-19 pandemic - A case series. 61
33754122 2021
The role of optic nerve sheath diameter ultrasound in brain infection. 61
33728383 2021
Intracranial hemorrhage due to central venous occlusion from hemodialysis access: A case report. 61
33796444 2021
Extracorporeal renal and liver support in pediatric acute liver failure. 61
32500250 2021
Estimation of intracranial pressure by ultrasound of the optic nerve sheath in an animal model of intracranial hypertension. 61
33775322 2021
Idiopathic intracranial hypertension in confirmed case of cutaneous-hemolytic loxoscelism. 61
32894036 2021
Infantile idiopathic intracranial hypertension in the setting of recent laminectomy and filum lysis for tethered cord syndrome: a case report and literature review. 61
32748011 2021
Decompressive Craniectomy in Traumatic Brain Injury-Craniectomy-Related and Cranioplasty-Related Complications in a Single Center. 61
33444838 2021
Cerebrospinal Fluid Analysis. 61
33788511 2021
Cerebrospinal Fluid Analysis for Viruses by Metagenomic Next-Generation Sequencing in Pediatric Encephalitis: Not Yet Ready for Prime Time? 61
33206020 2021
Traumatic Brain Injury Practice Guidelines: Variability in U.K. PICUs. 61
33009356 2021
International Consensus Statement: Spontaneous Cerebrospinal Fluid Rhinorrhea. 61
33099888 2021
Sinus pericranii-unusual anatomic obstacle to posterior decompression on an amniotic band sequence. 61
32705328 2021
Disappointing results of spring-assisted cranial vault expansion in patients with Crouzon syndrome presenting with sagittal synostosis. 61
33794489 2021
Cerebellar swelling after surgery for medulloblastoma with leptomeningeal dissemination in children. A case based-update. 61
33340509 2021
Diagnosis and treatment of idiopathic intracranial hypertension. 61
33631966 2021
Subacute vision loss after microvascular decompression for trigeminal neuralgia. 61
33811522 2021
Assessment of Pediatric Pseudotumor Cerebri Clinical Characteristics and Outcomes. 61
33148096 2021
Four Athenas - Europe's first female neurosurgeons. 61
33558183 2021
Solid vs. cystic predominance in posterior fossa hemangioblastomas: implications for cerebrovascular risks and patient outcome. 61
33811520 2021
Hydrocephalus Caused by Primary Fourth Ventricle Outlet Obstruction: Our Experience and Literature Review. 61
33444837 2021
Meningitis in the Setting of Frontoethmoidal and Temporal Meningoencephaloceles. 61
33791067 2021
Sensitivity and specificity of neuroimaging signs in patients with idiopathic intracranial hypertension. 61
33678064 2021
Letter to the editors: comment on "Emerging themes in idiopathic intracranial hypertension". 61
33474621 2021
Diagnostic challenges in neoplastic meningitis presenting as intracranial hypertension. 61
33692049 2021
Idiopathic intracranial hypertension and visual function in North Indian population. 61
33781109 2021
Telemetric monitoring in idiopathic intracranial hypertension demonstrates intracranial pressure in a case with sight-threatening disease. 61
33411042 2021
Intracranial hypertension and papilloedema as a complication to low antiretroviral therapy adherence in a man living with chronic HIV. 61
33727285 2021
Intracranial Venous Sinus Stenting in Idiopathic Intracranial Hypertension: A Case Report and Review of the Literature. 61
33802706 2021
Lumbo-peritoneal shunt as treatment modality for visual symptoms in idiopathic intracranial hypertension: A single institution experience. 61
32482535 2021
Multidisciplinary management of idiopathic intracranial hypertension in pregnancy: case series and narrative review. 61
33757747 2021
Multimodal Imaging in a Case of Peripapillary Choroidal Neovascular Membrane Associated With Idiopathic Intracranial Hypertension. 61
32235220 2021
Acetazolamide aggravated diabetic ketoacidosis severity in a boy post-transplantation thalassaemia with intracranial hypertension. 61
32364305 2021
Approach to patient with unilateral optic disc edema and normal visual function. 61
33799215 2021
Venous hypertension caused by a meningioma involving the sigmoid sinus: case report. 61
33731025 2021
Central nervous system candidiasis beyond neonates: Lessons from a nationwide study. 61
32577733 2021
[CT and MRI Findings of Cortical Venous Thrombosis and Cerebral Venous Sinus Thrombosis]. 61
33762445 2021
Clinical Decision Support for Traumatic Brain Injury: Identifying a Framework for Practical Model-Based Intracranial Pressure Estimation at Multihour Timescales. 61
33749613 2021
Sinking bullet syndrome: A unique case of transhemispheric migration. 61
33774506 2021
A new model outperforming RPA and DS-GPA scores for individualized survival prediction of patients following whole brain irradiation for brain metastasis. 61
33678525 2021
Correlation between intracranial pressure and venous sinus pressures in patients undergoing cerebral venography and manometry. 61
33674395 2021
Detrimental effects of intrahospital transport on cerebral metabolism in patients suffering severe aneurysmal subarachnoid hemorrhage. 61
33711812 2021
Paediatric arachnoid cysts: Surgical outcomes from a Singapore children's hospital. 61
33581782 2021
Headache and Bilateral Optic Disc Edema as the Initial Manifestation of Vogt-Koyanagi-Harada Disease. 61
32102009 2021
Doxycycline-induced idiopathic intracranial hypertension in a patient with Lyme disease. 61
33600108 2021
Pathogeny of cerebral venous thrombosis in SARS-Cov-2 infection: Case reports. 61
33725828 2021
Endoscopic Bilateral Optic Nerve Decompression for Treatment of Idiopathic Intracranial Hypertension. 61
33806665 2021
Pineal alveolar rhabdomyosarcoma with PAX3:NCOA2 fusion inducing OLIG2 sexpression, a potential pitfall in the central nervous system. 61
33666281 2021
Tension pneumocephalus, an uncommon complication of oxygen therapy in preterm newborns. Presentation of a case and literature review. 61
31784352 2021
Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients. 61
33774980 2021

Variations for Intracranial Hypertension

Expression for Intracranial Hypertension

Search GEO for disease gene expression data for Intracranial Hypertension.

Pathways for Intracranial Hypertension

Pathways related to Intracranial Hypertension according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
12.61 SERPINC1 F9 F5 F3 F2
Show member pathways
4 11.63 TNF IL1B CXCL10 AQP4 AQP1
Show member pathways
6 11.62 TNF SERPINE1 IL1B F3
7 11.27 TNF IL1B CXCL10
8 11.26 SERPINE1 SERPINC1 F9 F5 F3 F2
9 11.04 TNF MTHFR IL1B
10 10.41 TNF PRL

GO Terms for Intracranial Hypertension

Cellular components related to Intracranial Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.07 TRPM4 TNF SLC12A3 SERPINE1 SERPINC1 F9
2 extracellular region GO:0005576 9.73 TNF SERPINE1 SERPINC1 PRL IL1B F9
3 collagen-containing extracellular matrix GO:0062023 9.63 SERPINE1 SERPINC1 F9 F3 F2 APOH
4 extracellular space GO:0005615 9.36 TNF SERPINE1 SERPINC1 PRL IL1B F9

Biological processes related to Intracranial Hypertension according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 10.03 TRPM4 SLC12A3 CTNS AQP4 AQP1 ABCC8
2 cellular protein metabolic process GO:0044267 9.91 SERPINC1 PRL F5 F2
3 cytokine-mediated signaling pathway GO:0019221 9.91 TWIST1 TNF IL1B F3 CXCL10
4 cellular response to lipopolysaccharide GO:0071222 9.88 TNF SERPINE1 IL1B CXCL10
5 negative regulation of angiogenesis GO:0016525 9.83 PRL CXCL10 APOH ABCC8
6 blood coagulation GO:0007596 9.83 SERPINC1 F9 F5 F3 F2
7 regulation of insulin secretion GO:0050796 9.79 TNF IL1B ABCC8
8 negative regulation of osteoblast differentiation GO:0045668 9.76 TWIST1 TRPM4 TNF
9 negative regulation of endothelial cell proliferation GO:0001937 9.71 TNF PRL APOH
10 positive regulation of JAK-STAT cascade GO:0046427 9.65 TNF PRL F2
11 positive regulation of neuroinflammatory response GO:0150078 9.63 TNF IL1B
12 multicellular organismal water homeostasis GO:0050891 9.63 AQP4 AQP1
13 negative regulation of neurogenesis GO:0050768 9.63 TNF IL1B ABCC8
14 regulation of establishment of endothelial barrier GO:1903140 9.62 TNF IL1B
15 negative regulation of vascular wound healing GO:0061044 9.61 TNF SERPINE1
16 vascular endothelial growth factor production GO:0010573 9.6 TNF IL1B
17 cellular water homeostasis GO:0009992 9.59 AQP4 AQP1
18 blood coagulation, intrinsic pathway GO:0007597 9.58 F9 F2 APOH
19 positive regulation of fever generation GO:0031622 9.57 TNF IL1B
20 positive regulation of interleukin-8 production GO:0032757 9.56 TNF SERPINE1 IL1B F3
21 sequestering of triglyceride GO:0030730 9.55 TNF IL1B
22 positive regulation of angiogenesis GO:0045766 9.55 TWIST1 SERPINE1 IL1B F3 AQP1
23 positive regulation of blood coagulation GO:0030194 9.54 SERPINE1 F2 APOH
24 regulation of blood coagulation GO:0030193 9.5 SERPINC1 F2 APOH
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 TNF IL1B
26 negative regulation of fibrinolysis GO:0051918 9.13 SERPINE1 F2 APOH
27 hemostasis GO:0007599 9.02 SERPINC1 F9 F5 F3 F2

Molecular functions related to Intracranial Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.26 SERPINC1 F2 CXCL10 APOH
2 protease binding GO:0002020 8.92 TNF SERPINE1 SERPINC1 F3

Sources for Intracranial Hypertension

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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