MCID: INT075
MIFTS: 57

Intracranial Hypertension

Categories: Neuronal diseases

Aliases & Classifications for Intracranial Hypertension

MalaCards integrated aliases for Intracranial Hypertension:

Name: Intracranial Hypertension 12 54 55 44 15 73
Raised Intracranial Pressure 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9428
MeSH 44 D019586
NCIt 50 C84791
SNOMED-CT 68 28073009
UMLS 73 C0151740

Summaries for Intracranial Hypertension

NINDS : 54 Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating sounds within the head, closely mimic symptoms of large brain tumors.

MalaCards based summary : Intracranial Hypertension, also known as raised intracranial pressure, is related to papilledema and brain edema, and has symptoms including vomiting, papilledema and headache. An important gene associated with Intracranial Hypertension is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Atracurium and Cisatracurium have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

Disease Ontology : 12 A brain disease that is characterized by high pressure inside the skull, the brain tissue and cerebrospinal fluid, has symptom headache, has symptom vomiting, has symptom altered mental status, has symptom papilledema.

Related Diseases for Intracranial Hypertension

Diseases related to Intracranial Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 422)
# Related Disease Score Top Affiliating Genes
1 papilledema 31.1 APOH F2
2 brain edema 30.4 AQP1 AQP4 IL1B
3 thrombosis 30.1 APOH F2 F3 F5 MTHFR SERPINC1
4 sagittal sinus thrombosis 30.0 F2 F3 F5 SERPINC1
5 thrombocytosis 29.9 F2 F3 SERPINC1
6 myelitis 29.9 APOH AQP4 TNF
7 thrombophilia due to thrombin defect 29.8 APOH F2 F3 F5 MTHFR SERPINC1
8 transverse myelitis 29.7 APOH AQP4 TNF
9 behcet syndrome 29.6 APOH F5 IL1B SERPINC1 TNF
10 adult respiratory distress syndrome 29.6 F2 SERPINE1 TNF
11 pulmonary edema 29.6 F2 IL1B TNF
12 demyelinating disease 29.5 AQP4 IL1B TNF
13 sickle cell anemia 29.5 F2 MTHFR TNF
14 protein c deficiency 29.5 F2 F5 MTHFR SERPINC1
15 migraine with or without aura 1 29.3 APOH MTHFR TNF
16 antiphospholipid syndrome 29.2 APOH F2 F3 F5 MTHFR SERPINC1
17 thrombophlebitis 29.2 APOH F2 F5 MTHFR SERPINC1 SERPINE1
18 thrombophilia 29.1 APOH F2 F3 F5 MTHFR SERPINC1
19 stroke, ischemic 28.6 APOH AQP4 F2 F3 F5 FGA
20 intracranial hypertension, idiopathic 12.8
21 gapo syndrome 11.4
22 craniosynostosis 1 11.2
23 craniosynostosis 4 11.2
24 craniosynostosis 2 11.2
25 craniosynostosis 3 11.2
26 craniosynostosis 6 11.2
27 craniosynostosis 7 11.2
28 primary melanoma of the central nervous system 11.2
29 melanosis, neurocutaneous 11.0
30 brain injury 10.5
31 traumatic brain injury 10.5
32 headache 10.5
33 hydrocephalus 10.3
34 meningitis 10.3
35 prothrombin deficiency 10.3 F2 F3
36 may-thurner syndrome 10.3 APOH F5
37 subependymoma 10.3 AQP1 AQP4
38 acanthamoeba keratitis 10.3 APOH F5
39 paracetamol poisoning 10.3 F2 F5
40 pregnancy loss, recurrent 1 10.3 APOH F5
41 cerebral falx meningioma 10.3 F2 F3
42 acquired hemophilia 10.2 F3 F5
43 acquired hemophilia a 10.2 F3 F5
44 fibrinolytic defect 10.2 SERPINC1 SERPINE1
45 hemoglobin e disease 10.2 F2 F5
46 heparin-induced thrombocytopenia 10.2 F3 SERPINC1
47 qualitative platelet defect 10.2 F2 F3
48 alpha-2-plasmin inhibitor deficiency 10.2 F2 SERPINC1
49 intracranial embolism 10.2 F2 SERPINC1
50 aspirin allergy 10.2 SERPINC1 SERPINE1

Graphical network of the top 20 diseases related to Intracranial Hypertension:



Diseases related to Intracranial Hypertension

Symptoms & Phenotypes for Intracranial Hypertension

Symptoms:

12
  • vomiting
  • papilledema
  • headache
  • altered mental status

UMLS symptoms related to Intracranial Hypertension:


bulging fontanelle

MGI Mouse Phenotypes related to Intracranial Hypertension:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 APOH AQP1 AQP4 F2 F3 F5
2 cardiovascular system MP:0005385 10.27 AQP1 AQP4 F2 F3 F5 FGA
3 growth/size/body region MP:0005378 10.18 AQP1 AQP4 F2 F3 F5 HSD11B1
4 hematopoietic system MP:0005397 10.16 AQP1 AQP4 F2 F3 FGA HSD11B1
5 immune system MP:0005387 10.06 AQP4 F2 F3 FGA HSD11B1 IL1B
6 mortality/aging MP:0010768 10.03 APOH AQP1 AQP4 F2 F3 F5
7 integument MP:0010771 10.02 F2 F3 F5 FGA HSD11B1 IL1B
8 nervous system MP:0003631 9.93 AQP1 AQP4 F2 F3 F5 FGA
9 liver/biliary system MP:0005370 9.87 F5 FGA HSD11B1 MTHFR SERPINC1 SERPINE1
10 respiratory system MP:0005388 9.5 AQP1 AQP4 F2 F3 HSD11B1 SERPINE1
11 vision/eye MP:0005391 9.23 AQP1 AQP4 F3 FGA MTHFR SERPINC1

Drugs & Therapeutics for Intracranial Hypertension

Drugs for Intracranial Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 255)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
2
Cisatracurium Approved Phase 4 96946-41-7
3
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 69-65-8 453 6251
4
Cosyntropin Approved Phase 4 16960-16-0 16129617
5
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
6
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
7
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
8
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
9
Racepinephrine Approved Phase 4 329-65-7 838
10
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
11
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
12 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
13 Cholinergic Agents Phase 4
14 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
15 Cholinergic Antagonists Phase 4
16 Neuromuscular Blocking Agents Phase 4
17 Neuromuscular Nondepolarizing Agents Phase 4
18 Neuromuscular Agents Phase 4
19 diuretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
22 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
23 Vasoconstrictor Agents Phase 4,Phase 2,Not Applicable
24 (1-6)-alpha-glucomannan Phase 4
25 Manna Phase 4
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
27 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
28 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
29 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Dermatologic Agents Phase 4,Phase 3,Phase 2
32 Epinephryl borate Phase 4
33
Quinine Approved Phase 2, Phase 3 130-95-0 3034034 8549
34
Dexmedetomidine Approved, Vet_approved Phase 3,Phase 2,Not Applicable 113775-47-6 68602 5311068
35
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 1302 156391
36
Aspirin Approved, Vet_approved Phase 2, Phase 3,Not Applicable 50-78-2 2244
37
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3 5284371
38
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
39
Acetaminophen Approved Phase 2, Phase 3,Phase 1 103-90-2 1983
40
Acetazolamide Approved, Vet_approved Phase 2, Phase 3,Phase 3,Not Applicable 59-66-5 1986
41
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
42
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
43
Rifampicin Approved Phase 3,Phase 2 13292-46-1 5458213 5381226
44
Tocopherol Approved, Investigational Phase 3 1406-66-2 14986
45
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
46
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
47
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 50-02-2 5743
48
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
49
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
50
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941

Interventional clinical trials:

(show top 50) (show all 228)
# Name Status NCT ID Phase Drugs
1 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Unknown status NCT02404779 Phase 4 cisatracurium besilate
2 Comparison of 20% Mannitol and 3% Hypertonic Saline for Cerebral Relaxation During Elective Supratentorial Craniotomies Unknown status NCT01745081 Phase 4 20% mannitol bolus administration;Hypertonic saline 3% bolus administration
3 Mannitol Versus Hypertonic Saline Solution in the Treatment of Elevated Intracranial Pressure Completed NCT00447018 Phase 4 20% mannitol;7.45% hypertonic saline solution
4 Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy Completed NCT02037815 Phase 4 20% mannitol solution, 125 ml, IV infusion in 15 min;3.1% sodium chloride solution, 125 ml, IV infusion in 15 min
5 Mannitol Improves Cerebral Oxygen Saturation Completed NCT02091180 Phase 4 Mannitol;Control
6 Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache Completed NCT02394457 Phase 4 Cosyntropin
7 Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome Completed NCT00266656 Phase 4 Humatrope
8 Antiacne Medications Pseudotumor Cerebri Recruiting NCT02149615 Phase 4
9 Neurosciences-Intensive Care Unit Electrical Stimulation Recruiting NCT03547687 Phase 4
10 SOLFAMU Study of Nasal Brushing Collected OLFActory MUcosa Samples in the Diagnosis of Human Encephalopathies Recruiting NCT02951559 Phase 4
11 Esmolol for the Treatment of Hypertension After Intracerebral Hemorrhage Study (ETHICHS) Not yet recruiting NCT03743103 Phase 4 Brevibloc, 10 Mg/mL Intravenous Solution;Nitroprusside, Sodium
12 Comparison of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension and Cerebral Monitoring Terminated NCT00795587 Phase 4 variation of mannitol dose
13 Effect of Intrathoracic Pressure Regulation on Traumatic Brain Injury Terminated NCT01824589 Phase 4
14 ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) Patients Withdrawn NCT00793416 Phase 4
15 Clinical Value of Noninvasive Intracranial Pressure Measurement Unknown status NCT02130219 Phase 2, Phase 3
16 The DECRA Trial: Early Decompressive Craniectomy in Patients With Severe Traumatic Brain Injury Unknown status NCT00155987 Phase 3
17 Randomized Trial of Erythropoietin During Cerebral Malaria Unknown status NCT00697164 Phase 2, Phase 3 Placebo;Erythropoietin
18 Mannitol as Adjunct Therapy for Childhood Cerebral Malaria Unknown status NCT00113854 Phase 3 Mannitol
19 Idiopathic Intracranial Hypertension Treatment Trial Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
20 Preventive Sodium Lactate and Traumatic Brain Injury Completed NCT00995683 Phase 2, Phase 3 half molar sodium lactate;isotonic sodium chloride
21 Impact of Ventricular Catheter Used With Antimicrobial Agents on Patients With a Ventricular Catheter Completed NCT00286104 Phase 3
22 Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness Completed NCT00664001 Phase 3
23 Treatment Protocol for Hemophagocytic Lymphohistiocytosis 2004 Completed NCT00426101 Phase 3 Dexamethasone;Etoposide;Cyclosporin
24 Surgical Idiopathic Intracranial Hypertension Treatment Trial Recruiting NCT03501966 Phase 3 Acetazolamide
25 Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients Recruiting NCT03143751 Phase 3 NaCl20% (Continuous hyperosmolar therapy)
26 Esmolol Versus Dexmedetomidine During Intracranial Procedures Recruiting NCT02563288 Phase 3 Esmolol;Dexmedetomidine
27 Sub Arachnoid Neurocysticercosis Treatment Outcome (SANTO) Recruiting NCT02947581 Phase 3 Albendazole and praziquantel;Albendazole and praziquantel placebo
28 Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension Terminated NCT00622570 Phase 3 Pentobarbital;thiopental
29 Mannitol vs HS to Treat ICHT After Severe TBI : Comparison on PtiO2 and Microdialysis Values Terminated NCT01028339 Phase 3 Hypertonic saline;Mannitol
30 Sodium-Lactate and Traumatic Brain Injury Terminated NCT00319345 Phase 2, Phase 3 Mannitol, Sodium-Lactate
31 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3 Mannitol;Hypertonic Saline
32 Normal Pressure Hydrocephalus Treatment by Acetazolamide Terminated NCT02163330 Phase 3 Acetazolamide;sugar pill
33 Clinical Trial of Growth Hormone in MPS I, II, and VI Terminated NCT00748969 Phase 2, Phase 3 Somatropin (DNA origin)
34 Hypothermia in Children After Trauma Terminated NCT00222742 Phase 3
35 Intraventricular Tissue Plasminogen Activator (tPA) in the Management of Aneurysmal Subarachnoid Hemorrhage Unknown status NCT01098890 Phase 2 Tissue Plasminogen Activator;Placebo
36 Dexmedetomidine-based Sedation in Neurocritical Care Patients Unknown status NCT02252523 Phase 2 Dexmedetomidine
37 Study the Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Optic Nerve Disease Unknown status NCT01834079 Phase 1, Phase 2
38 Impact of Cardiac Blood Flow on Cerebral Blood Flow in Patients With Severe Traumatic Brain Injury Unknown status NCT02019810 Phase 2 Norepinephrine;Dobutamine and norepinephrine
39 Intravenous Immunoglobulin for Acute Intracranial Hemorrhage Unknown status NCT02782897 Phase 2 Immunoglobulin Therapy
40 Ketamine and Glutamate After Brain Injury : a Microdialysis Study Unknown status NCT02232347 Phase 2 Ketamine;Sufentanil
41 Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension. Completed NCT02017444 Phase 2 AZD4017
42 Dexamethasone in Cryptococcal Meningitis Completed NCT00000776 Phase 2 Flucytosine;Fluconazole;Amphotericin B;Dexamethasone
43 A Pilot Study: Safety & TOlerability of Hypertonic Saline Administration Via IntraOsseous Access Completed NCT03276494 Phase 2 injection of intraosseous hypertonic saline
44 Gliadel Wafer and Fluorescence-Guided Surgery With 5-ALA Followed by Radiation Therapy And Temozolomide in Treating Patients With Primary Glioblastoma Completed NCT01310868 Phase 2 5-ALA;Gliadel wafers;Concomitant chemotherapy as normal based on standard clinical protocols determined by the neuro-oncologist;Adjuvant chemotherapy as normal based on standard clinical protocols determined by the neuro-oncologist
45 Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke Completed NCT01428401 Phase 2 Chinese Herb Astragalus membranaceus
46 HyperHAES Versus Placebo - Effect on Intracranial Pressure in SAH Patients Completed NCT00199706 Phase 2 7.2% NaCl in 6% hydroxyethyl starch solution
47 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI) Completed NCT00974259 Phase 2
48 Phase 2 a Study to Assess Safety and Pharmacokinetics of VAS203 in Patients With Traumatic Brain Injury Completed NCT02012582 Phase 2 VAS203;Saline
49 Effects of Saline on Circulation in Children Completed NCT01668277 Phase 2 7.2% NaCl;0.9% NaCl
50 Acetazolamide for Treating NPH in Shunt-candidates Patients Recruiting NCT03779594 Phase 2 Acetazolamide

Search NIH Clinical Center for Intracranial Hypertension

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: intracranial hypertension

Genetic Tests for Intracranial Hypertension

Anatomical Context for Intracranial Hypertension

MalaCards organs/tissues related to Intracranial Hypertension:

41
Brain, Liver, Bone, Ovary, Testes, Pituitary, Spinal Cord

Publications for Intracranial Hypertension

Articles related to Intracranial Hypertension:

(show top 50) (show all 1636)
# Title Authors Year
1
Dexmedetomidine for Refractory Intracranial Hypertension. ( 28122469 )
2019
2
A quantitative and semi-automatic measurement of transverse sinus stenosis improves idiopathic intracranial hypertension diagnostic accuracy. ( 29913177 )
2018
3
Forgetting the fundoscope - A case of fulminant idiopathic intracranial hypertension causing rapid visual loss. ( 29396063 )
2018
4
Cisternostomy: Surgical Alternative for Patients with Refractory Posttraumatic Intracranial Hypertension. ( 29433168 )
2018
5
Headache Linked to Intracranial Hypertension and Hypertrophic Pachymeningitis as the Initial and Dominant Presentation of Granulomatosis With Polyangiitis. Case Report and Review of the Recent Literature. ( 29446067 )
2018
6
Update on Idiopathic Intracranial Hypertension. ( 29808423 )
2018
7
Papilledema in Idiopathic Intracranial Hypertension. ( 29399792 )
2018
8
Meta-analysis and systematic review of population-based epidemiological studies in idiopathic intracranial hypertension. ( 29953685 )
2018
9
Correlation between angiographic stenosis and physiologic venous sinus outflow obstruction in idiopathic intracranial hypertension. ( 29858399 )
2018
10
Pressure variations in cerebral venous sinuses of idiopathic intracranial hypertension patients. ( 29922401 )
2018
11
Idiopathic intracranial hypertension associated with anaemia, secondary to antiretroviral drug in a human immunodeficiency virus positive patient. ( 29283154 )
2018
12
Sonographic assessment of optic nerve and ophthalmic vessels in patients with idiopathic intracranial hypertension. ( 29799769 )
2018
13
Therapeutic lumbar puncture for headache in idiopathic intracranial hypertension: Minimal gain, is it worth the pain? ( 29911422 )
2018
14
Idiopathic intracranial hypertension and bariatric surgery: a literature review and a presentation of two cases. ( 29385843 )
2018
15
Idiopathic intracranial hypertension: consensus guidelines on management. ( 29903905 )
2018
16
CTA/V detection of bilateral sigmoid sinus dehiscence and suspected idiopathic intracranial hypertension in unilateral pulsatile tinnitus. ( 29417173 )
2018
17
Noninvasive Assessment of Intracranial Pressure Status in Idiopathic Intracranial Hypertension Using Displacement Encoding with Stimulated Echoes (DENSE) MRI: A Prospective Patient Study with Contemporaneous CSF Pressure Correlation. ( 29284598 )
2018
18
In Reply to "Cisternostomy: Surgical Alternative for Patients with Refractory Posttraumatic Intracranial Hypertension". ( 29433169 )
2018
19
Headache frequency and symptoms of depression as predictors of disability in patients with idiopathic intracranial hypertension. ( 29904836 )
2018
20
Long-term visual outcome in a Danish population of patients with idiopathic intracranial hypertension. ( 29405582 )
2018
21
Intracranial hypertension and cerebral autoregulation: a systematic review and meta-analysis. ( 29421451 )
2018
22
Complications of Optic Nerve Sheath Fenestration as a Treatment for Idiopathic Intracranial Hypertension. ( 29420144 )
2018
23
Anatomic measurements of cerebral venous sinuses in idiopathic intracranial hypertension patients. ( 29856739 )
2018
24
Characterising the patient experience of diagnostic lumbar puncture in idiopathic intracranial hypertension: a cross-sectional online survey. ( 29848770 )
2018
25
Intracranial fluid dynamics changes in idiopathic intracranial hypertension: pre and post therapy. ( 29807514 )
2018
26
Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension. ( 29298687 )
2018
27
Transverse venous stenting for the treatment of idiopathic intracranial hypertension, or pseudotumor cerebri. ( 29961386 )
2018
28
Treatment of idiopathic intracranial hypertension via stereotactic placement of biventriculoperitoneal shunts. ( 29393752 )
2018
29
Transverse venous sinus stenting for idiopathic intracranial hypertension: Safety and feasibility. ( 29882475 )
2018
30
Bilateral Venous Sinus Stenosis: Idiopathic Intracranial Hypertension and Endovascular Venous Sinus Stenting: 2-Dimensional Operative Video. ( 29444263 )
2018
31
Electroretinography in idiopathic intracranial hypertension: comparison of the pattern ERG and the photopic negative response. ( 29139045 )
2018
32
Analysis of petrous apex meningocele associated with meningioma: is there any relation with chronic intracranial hypertension? ( 29188303 )
2018
33
The utility of the lumbar puncture in idiopathic intracranial hypertension. ( 29973055 )
2018
34
Rapid effect of depletive lumbar puncture on papilledema in intracranial hypertension. ( 29903588 )
2018
35
Venous sinus stenting lowers the intracranial pressure in patients with idiopathic intracranial hypertension. ( 29871989 )
2018
36
Idiopathic intracranial hypertension as a presenting sign of adrenal insufficiency. ( 29375882 )
2018
37
Understanding the complex pathophysiology of idiopathic intracranial hypertension and the evolving role of venous sinus stenting: a comprehensive review of the literature. ( 29961379 )
2018
38
Unexpected occlusion of the contralateral transverse sinus after stenting for idiopathic intracranial hypertension. ( 29976107 )
2018
39
Inflammatory gene expression signatures in idiopathic intracranial hypertension: possible implications in microgravity-induced ICP elevation. ( 29354685 )
2018
40
Intracranial Hypertension Secondary to Cervical Dural Arteriovenous Fistula. ( 30283565 )
2018
41
Development of an Intracranial Dural Arteriovenous Fistula after Venous Sinus Stenting for Idiopathic Intracranial Hypertension. ( 29563208 )
2018
42
Downstream TRPM4 Polymorphisms are associated with Intracranial Hypertension and Statistically Interact with ABCC8 Polymorphisms in a Prospective Cohort of Severe Traumatic Brain Injury. ( 30484364 )
2018
43
A Precision Medicine Approach to Cerebral Edema and Intracranial Hypertension after Severe Traumatic Brain Injury: Quo Vadis? ( 30406315 )
2018
44
A clinical decision rule to predict intracranial hypertension in severe traumatic brain injury. ( 30265194 )
2018
45
Quality And Feasibility of Sonographic Measurement of the Optic Nerve Sheath Diameter to Estimate the Risk of Raised Intracranial Pressure After Traumatic Brain Injury in Prehospital Setting. ( 30118380 )
2018
46
Combined surgery and embolization to treat ruptured cerebral aneurysms with cerebral hematoma and intracranial hypertension: a retrospective analysis and review of the literature. ( 30396604 )
2018
47
Mesalazine treatment causing resolution of intracranial hypertension secondary to ulcerative colitis: A case report. ( 30544405 )
2018
48
Fibrous dysplasia of occipital bone revealed by acute intracranial hypertension. ( 30327834 )
2018
49
Advances in the understanding of headache in idiopathic intracranial hypertension. ( 30547900 )
2018
50
Headache in Idiopathic Intracranial Hypertension. ( 30152165 )
2018

Variations for Intracranial Hypertension

Expression for Intracranial Hypertension

Search GEO for disease gene expression data for Intracranial Hypertension.

Pathways for Intracranial Hypertension

Pathways related to Intracranial Hypertension according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 APOH F2 F3 F5 FGA SERPINC1
2
Show member pathways
12.6 F2 F3 F5 FGA SERPINC1
3
Show member pathways
12 F3 IL1B SERPINE1 TNF
4 11.92 AQP4 IL1B SSTR1 TNF
5
Show member pathways
11.89 F2 IL1B MTHFR SERPINE1 TNF
6
Show member pathways
11.79 F2 IL1B TNF
7 11.7 AQP1 AQP4 IL1B TNF
8
Show member pathways
11.63 F2 F3 F5 FGA SERPINC1 SERPINE1
9 11.55 F3 IL1B SERPINE1 TNF
10 11.24 F2 F3 F5 FGA SERPINC1 SERPINE1
11 11.04 IL1B MTHFR TNF
12 10.87 IL1B TNF
13 10.7 IL1B TNF

GO Terms for Intracranial Hypertension

Cellular components related to Intracranial Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.92 APOH AQP1 F2 FGA IL1B SERPINC1
2 extracellular region GO:0005576 9.81 APOH F2 F3 F5 FGA IL1B
3 external side of plasma membrane GO:0009897 9.76 AQP4 F2 FGA TNF
4 endoplasmic reticulum lumen GO:0005788 9.71 F2 F5 FGA SERPINC1
5 platelet alpha granule GO:0031091 9.43 F5 FGA
6 platelet alpha granule lumen GO:0031093 9.43 F5 FGA SERPINE1
7 collagen-containing extracellular matrix GO:0062023 9.35 APOH F3 FGA SERPINC1 SERPINE1
8 extracellular space GO:0005615 9.28 APOH F2 F3 F5 FGA IL1B
9 plasma membrane GO:0005886 10.11 AQP1 AQP4 F2 F3 F5 FGA

Biological processes related to Intracranial Hypertension according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.86 F2 F5 FGA SERPINC1
2 positive regulation of angiogenesis GO:0045766 9.8 AQP1 F3 IL1B SERPINE1
3 platelet degranulation GO:0002576 9.76 APOH F5 FGA SERPINE1
4 blood coagulation GO:0007596 9.72 F2 F3 F5 FGA SERPINC1
5 water transport GO:0006833 9.63 AQP1 AQP4
6 blood coagulation, intrinsic pathway GO:0007597 9.63 APOH F2
7 negative regulation of lipid catabolic process GO:0050995 9.62 IL1B TNF
8 positive regulation of glial cell proliferation GO:0060252 9.62 IL1B TNF
9 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.61 IL1B TNF
10 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IL1B TNF
11 positive regulation of interleukin-8 production GO:0032757 9.61 IL1B SERPINE1 TNF
12 negative regulation of blood coagulation GO:0030195 9.6 APOH SERPINE1
13 plasminogen activation GO:0031639 9.59 APOH FGA
14 multicellular organismal water homeostasis GO:0050891 9.58 AQP1 AQP4
15 positive regulation of chemokine biosynthetic process GO:0045080 9.58 IL1B TNF
16 fibrinolysis GO:0042730 9.58 F2 FGA SERPINE1
17 regulation of establishment of endothelial barrier GO:1903140 9.57 IL1B TNF
18 positive regulation of neuroinflammatory response GO:0150078 9.55 IL1B TNF
19 positive regulation of fever generation GO:0031622 9.54 IL1B TNF
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 FGA IL1B TNF
21 chronic inflammatory response to antigenic stimulus GO:0002439 9.52 IL1B TNF
22 sequestering of triglyceride GO:0030730 9.51 IL1B TNF
23 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 IL1B TNF
24 positive regulation of blood coagulation GO:0030194 9.43 APOH F2 SERPINE1
25 regulation of blood coagulation GO:0030193 9.33 APOH F2 SERPINC1
26 negative regulation of fibrinolysis GO:0051918 9.13 APOH F2 SERPINE1
27 hemostasis GO:0007599 9.02 F2 F3 F5 FGA SERPINC1

Molecular functions related to Intracranial Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 water channel activity GO:0015250 9.16 AQP1 AQP4
2 water transmembrane transporter activity GO:0005372 8.96 AQP1 AQP4
3 protease binding GO:0002020 8.92 F3 SERPINC1 SERPINE1 TNF

Sources for Intracranial Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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