Aliases & Classifications for Intracranial Hypertension

MalaCards integrated aliases for Intracranial Hypertension:

Name: Intracranial Hypertension 12 54 55 44 15 73
Raised Intracranial Pressure 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9428
MeSH 44 D019586
NCIt 50 C84791
UMLS 73 C0151740

Summaries for Intracranial Hypertension

NINDS : 54 Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating sounds within the head, closely mimic symptoms of large brain tumors.

MalaCards based summary : Intracranial Hypertension, also known as raised intracranial pressure, is related to intracranial hypertension, idiopathic and papilledema, and has symptoms including bulging fontanelle An important gene associated with Intracranial Hypertension is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. The drugs Mannitol and Atracurium have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Intracranial Hypertension

Diseases related to Intracranial Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 358)
# Related Disease Score Top Affiliating Genes
1 intracranial hypertension, idiopathic 34.2 AQP1 AQP4 SSTR1
2 papilledema 31.6 APOH F2
3 brain edema 30.3 AQP1 AQP4 IL1B
4 sagittal sinus thrombosis 30.2 F2 F3 F5 SERPINC1
5 transverse myelitis 29.9 APOH AQP4 TNF
6 myelitis 29.9 APOH AQP4 TNF
7 encephalitis 29.8 AQP4 CXCL10 IL1B
8 adult respiratory distress syndrome 29.7 F2 SERPINE1 TNF
9 protein c deficiency 29.5 F2 F5 MTHFR SERPINC1
10 peritonitis 29.3 AQP1 F2 IL1B TNF
11 pulmonary edema 29.2 F2 IL1B SERPINC1 TNF
12 thrombosis 29.0 APOH F2 F3 F5 MTHFR SERPINC1
13 demyelinating disease 28.8 AQP4 CXCL10 IL1B TNF
14 thrombophilia due to thrombin defect 28.7 APOH F2 F3 F5 MTHFR SERPINC1
15 antiphospholipid syndrome 28.6 APOH F2 F3 F5 MTHFR SERPINC1
16 multiple sclerosis 28.4 AQP4 CXCL10 IL1B TNF
17 placenta disease 28.4 APOH F3 F5 IL1B MTHFR SERPINC1
18 thrombophilia 28.0 APOH F2 F3 F5 MTHFR SERPINC1
19 stroke, ischemic 27.6 APOH AQP4 F2 F3 F5 MTHFR
20 gapo syndrome 11.2
21 craniosynostosis 1 11.0
22 craniosynostosis 4 11.0
23 craniosynostosis 2 11.0
24 craniosynostosis 3 11.0
25 craniosynostosis 6 11.0
26 craniosynostosis 7 11.0
27 may-thurner syndrome 10.9 APOH F5
28 melanosis, neurocutaneous 10.9
29 acanthamoeba keratitis 10.9 APOH F5
30 paracetamol poisoning 10.9 F2 F5
31 cerebral falx meningioma 10.8 F2 F3
32 splenic infarction 10.8 APOH F2
33 pregnancy loss, recurrent 1 10.8 APOH F5
34 acquired hemophilia a 10.8 F3 F5
35 fibrinolytic defect 10.8 SERPINC1 SERPINE1
36 acquired hemophilia 10.8 F3 F5
37 heparin-induced thrombocytopenia 10.7 F3 SERPINC1
38 hemoglobin e disease 10.7 F2 F5
39 qualitative platelet defect 10.7 F2 F3
40 alpha-2-plasmin inhibitor deficiency 10.7 F2 SERPINC1
41 argentine hemorrhagic fever 10.7 SERPINC1 SERPINE1
42 von willebrand disease, type 1 10.6 F2 F3
43 mesenteric vascular occlusion 10.6 F2 MTHFR
44 inappropriate adh syndrome 10.6 AQP1 AQP4
45 marburg hemorrhagic fever 10.6 F2 TNF
46 retinitis pigmentosa 73 10.6 F3 IL1B
47 central pontine myelinolysis 10.6 AQP1 AQP4
48 intestinal impaction 10.6 F2 F3 SERPINC1
49 fournier gangrene 10.6 F2 F3 SERPINC1
50 leech infestation 10.6 F2 F3 SERPINC1

Graphical network of the top 20 diseases related to Intracranial Hypertension:



Diseases related to Intracranial Hypertension

Symptoms & Phenotypes for Intracranial Hypertension

UMLS symptoms related to Intracranial Hypertension:


bulging fontanelle

MGI Mouse Phenotypes related to Intracranial Hypertension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 F2 APOH AQP1 F3 AQP4 F5
2 cardiovascular system MP:0005385 10.26 HSD11B1 F2 AQP1 F3 AQP4 F5
3 growth/size/body region MP:0005378 10.16 F2 AQP1 F3 AQP4 F5 HSD11B1
4 hematopoietic system MP:0005397 10.13 CXCL10 HSD11B1 F2 AQP1 F3 AQP4
5 mortality/aging MP:0010768 10.03 F2 APOH AQP1 F3 AQP4 F5
6 immune system MP:0005387 10.02 CXCL10 F2 F3 AQP4 HSD11B1 SERPINE1
7 nervous system MP:0003631 9.93 HSD11B1 F2 AQP1 F3 AQP4 F5
8 integument MP:0010771 9.92 HSD11B1 F2 F3 F5 SERPINE1 IL1B
9 respiratory system MP:0005388 9.5 HSD11B1 F2 AQP1 F3 AQP4 SERPINE1
10 vision/eye MP:0005391 9.17 AQP1 F3 AQP4 SSTR1 MTHFR TNF

Drugs & Therapeutics for Intracranial Hypertension

Drugs for Intracranial Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 241)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 69-65-8 453 6251
2
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
3
Cisatracurium Approved Phase 4 96946-41-7
4
Cosyntropin Approved Phase 4 16960-16-0 16129617
5
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
6
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
7
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
8
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
9
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
10
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
11
Racepinephrine Approved Phase 4 329-65-7 838
12 diuretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Cholinergic Agents Phase 4
14 Cholinergic Antagonists Phase 4
15 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Neuromuscular Agents Phase 4
17 Neuromuscular Blocking Agents Phase 4
18 Neuromuscular Nondepolarizing Agents Phase 4
19 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
20 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
21 Vasoconstrictor Agents Phase 4,Phase 2
22 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
23 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
24 (1-6)-alpha-glucomannan Phase 4
25 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
26 Dermatologic Agents Phase 4,Phase 3,Phase 2,Not Applicable
27 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
29 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Epinephryl borate Phase 4
32 Manna Nutraceutical Phase 4
33
Quinine Approved Phase 2, Phase 3 130-95-0 8549 3034034
34
Dexmedetomidine Approved, Vet_approved Phase 3,Phase 2,Not Applicable 113775-47-6 68602 5311068
35
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 1302 156391
36
Etoposide Approved Phase 3 33419-42-0 36462
37
Acetazolamide Approved, Vet_approved Phase 2, Phase 3,Phase 3,Not Applicable 59-66-5 1986
38
Rifampicin Approved Phase 3 13292-46-1 5458213 5381226
39
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
40
Aspirin Approved, Vet_approved Phase 2, Phase 3,Not Applicable 50-78-2 2244
41
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
42
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 50-02-2 5743
43
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
44
Acetaminophen Approved Phase 2, Phase 3,Phase 1 103-90-2 1983
45
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
46
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3 5284371
47
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
48
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
49
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
50
Praziquantel Approved, Investigational, Vet_approved Phase 3 55268-74-1 4891

Interventional clinical trials:

(show top 50) (show all 206)
# Name Status NCT ID Phase Drugs
1 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Unknown status NCT02404779 Phase 4 cisatracurium besilate
2 Comparison of 20% Mannitol and 3% Hypertonic Saline for Cerebral Relaxation During Elective Supratentorial Craniotomies Unknown status NCT01745081 Phase 4 20% mannitol bolus administration;Hypertonic saline 3% bolus administration
3 Mannitol Versus Hypertonic Saline Solution in the Treatment of Elevated Intracranial Pressure Completed NCT00447018 Phase 4 20% mannitol;7.45% hypertonic saline solution
4 Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy Completed NCT02037815 Phase 4 20% mannitol solution, 125 ml, IV infusion in 15 min;3.1% sodium chloride solution, 125 ml, IV infusion in 15 min
5 Mannitol Improves Cerebral Oxygen Saturation Completed NCT02091180 Phase 4 Mannitol;Control
6 Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache Completed NCT02394457 Phase 4 Cosyntropin
7 Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome Completed NCT00266656 Phase 4 Humatrope
8 Antiacne Medications Pseudotumor Cerebri Recruiting NCT02149615 Phase 4
9 SOLFAMU Study of Nasal Brushing Collected OLFActory MUcosa Samples in the Diagnosis of Human Encephalopathies Recruiting NCT02951559 Phase 4
10 Neurosciences-Intensive Care Unit Electrical Stimulation Not yet recruiting NCT03547687 Phase 4
11 Comparison of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension and Cerebral Monitoring Terminated NCT00795587 Phase 4 variation of mannitol dose
12 Effect of Intrathoracic Pressure Regulation on Traumatic Brain Injury Terminated NCT01824589 Phase 4
13 ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) Patients Withdrawn NCT00793416 Phase 4
14 Clinical Value of Noninvasive Intracranial Pressure Measurement Unknown status NCT02130219 Phase 2, Phase 3
15 The DECRA Trial: Early Decompressive Craniectomy in Patients With Severe Traumatic Brain Injury Unknown status NCT00155987 Phase 3
16 Randomized Trial of Erythropoietin During Cerebral Malaria Unknown status NCT00697164 Phase 2, Phase 3 Placebo;Erythropoietin
17 Mannitol as Adjunct Therapy for Childhood Cerebral Malaria Unknown status NCT00113854 Phase 3 Mannitol
18 Idiopathic Intracranial Hypertension Treatment Trial Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
19 Preventive Sodium Lactate and Traumatic Brain Injury Completed NCT00995683 Phase 2, Phase 3 half molar sodium lactate;isotonic sodium chloride
20 Impact of Ventricular Catheter Used With Antimicrobial Agents on Patients With a Ventricular Catheter Completed NCT00286104 Phase 3
21 Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness Completed NCT00664001 Phase 3
22 Treatment Protocol for Hemophagocytic Lymphohistiocytosis 2004 Completed NCT00426101 Phase 3 Dexamethasone;Etoposide;Cyclosporin
23 Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients Recruiting NCT03143751 Phase 3 NaCl20% (Continuous hyperosmolar therapy)
24 Esmolol Versus Dexmedetomidine During Intracranial Procedures Recruiting NCT02563288 Phase 3 Esmolol;Dexmedetomidine
25 Sub Arachnoid Neurocysticercosis Treatment Outcome (SANTO) Recruiting NCT02947581 Phase 3 Albendazole and praziquantel;Albendazole and praziquantel placebo
26 Surgical Idiopathic Intracranial Hypertension Treatment Trial Not yet recruiting NCT03501966 Phase 3 Acetazolamide
27 Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension Terminated NCT00622570 Phase 3 Pentobarbital;thiopental
28 Mannitol vs HS to Treat ICHT After Severe TBI : Comparison on PtiO2 and Microdialysis Values Terminated NCT01028339 Phase 3 Hypertonic saline;Mannitol
29 Sodium-Lactate and Traumatic Brain Injury Terminated NCT00319345 Phase 2, Phase 3 Mannitol, Sodium-Lactate
30 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3 Mannitol;Hypertonic Saline
31 Normal Pressure Hydrocephalus Treatment by Acetazolamide Terminated NCT02163330 Phase 3 Acetazolamide;sugar pill
32 Clinical Trial of Growth Hormone in MPS I, II, and VI Terminated NCT00748969 Phase 2, Phase 3 Somatropin (DNA origin)
33 Hypothermia in Children After Trauma Terminated NCT00222742 Phase 3
34 Intraventricular Tissue Plasminogen Activator (tPA) in the Management of Aneurysmal Subarachnoid Hemorrhage Unknown status NCT01098890 Phase 2 Tissue Plasminogen Activator;Placebo
35 Dexmedetomidine-based Sedation in Neurocritical Care Patients Unknown status NCT02252523 Phase 2 Dexmedetomidine
36 Study the Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Optic Nerve Disease Unknown status NCT01834079 Phase 1, Phase 2
37 Impact of Cardiac Blood Flow on Cerebral Blood Flow in Patients With Severe Traumatic Brain Injury Unknown status NCT02019810 Phase 2 Norepinephrine;Dobutamine and norepinephrine
38 Intravenous Immunoglobulin for Acute Intracranial Hemorrhage Unknown status NCT02782897 Phase 2 Immunoglobulin Therapy
39 Ketamine and Glutamate After Brain Injury : a Microdialysis Study Unknown status NCT02232347 Phase 2 Ketamine;Sufentanil
40 Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension. Completed NCT02017444 Phase 2 AZD4017
41 Dexamethasone in Cryptococcal Meningitis Completed NCT00000776 Phase 2 Flucytosine;Fluconazole;Amphotericin B;Dexamethasone
42 A Pilot Study: Safety & TOlerability of Hypertonic Saline Administration Via IntraOsseous Access Completed NCT03276494 Phase 2 injection of intraosseous hypertonic saline
43 Gliadel Wafer and Fluorescence-Guided Surgery With 5-ALA Followed by Radiation Therapy And Temozolomide in Treating Patients With Primary Glioblastoma Completed NCT01310868 Phase 2 5-ALA;Gliadel wafers;Concomitant chemotherapy as normal based on standard clinical protocols determined by the neuro-oncologist;Adjuvant chemotherapy as normal based on standard clinical protocols determined by the neuro-oncologist
44 Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke Completed NCT01428401 Phase 2 Chinese Herb Astragalus membranaceus
45 HyperHAES Versus Placebo - Effect on Intracranial Pressure in SAH Patients Completed NCT00199706 Phase 2 7.2% NaCl in 6% hydroxyethyl starch solution
46 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI) Completed NCT00974259 Phase 2
47 Phase 2 a Study to Assess Safety and Pharmacokinetics of VAS203 in Patients With Traumatic Brain Injury Completed NCT02012582 Phase 2 VAS203;Saline
48 Effects of Saline on Circulation in Children Completed NCT01668277 Phase 2 7.2% NaCl;0.9% NaCl
49 Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial) Recruiting NCT03354143 Phase 2 Standard Care;Intensive Treatment
50 Treatment With Tamoxifen in Cryptococcal Meningitis Recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole

Search NIH Clinical Center for Intracranial Hypertension

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: intracranial hypertension

Genetic Tests for Intracranial Hypertension

Anatomical Context for Intracranial Hypertension

MalaCards organs/tissues related to Intracranial Hypertension:

41
Brain, Liver, Bone, Endothelial, Ovary, Testes, Pituitary

Publications for Intracranial Hypertension

Articles related to Intracranial Hypertension:

(show top 50) (show all 921)
# Title Authors Year
1
A quantitative and semi-automatic measurement of transverse sinus stenosis improves idiopathic intracranial hypertension diagnostic accuracy. ( 29913177 )
2018
2
Forgetting the fundoscope - A case of fulminant idiopathic intracranial hypertension causing rapid visual loss. ( 29396063 )
2018
3
Cisternostomy: Surgical Alternative for Patients with Refractory Posttraumatic Intracranial Hypertension. ( 29433168 )
2018
4
Headache Linked to Intracranial Hypertension and Hypertrophic Pachymeningitis as the Initial and Dominant Presentation of Granulomatosis With Polyangiitis. Case Report and Review of the Recent Literature. ( 29446067 )
2018
5
Update on Idiopathic Intracranial Hypertension. ( 29808423 )
2018
6
Papilledema in Idiopathic Intracranial Hypertension. ( 29399792 )
2018
7
Meta-analysis and systematic review of population-based epidemiological studies in idiopathic intracranial hypertension. ( 29953685 )
2018
8
Correlation between angiographic stenosis and physiologic venous sinus outflow obstruction in idiopathic intracranial hypertension. ( 29858399 )
2018
9
Pressure variations in cerebral venous sinuses of idiopathic intracranial hypertension patients. ( 29922401 )
2018
10
Idiopathic intracranial hypertension associated with anaemia, secondary to antiretroviral drug in a human immunodeficiency virus positive patient. ( 29283154 )
2018
11
Sonographic assessment of optic nerve and ophthalmic vessels in patients with idiopathic intracranial hypertension. ( 29799769 )
2018
12
Therapeutic lumbar puncture for headache in idiopathic intracranial hypertension: Minimal gain, is it worth the pain? ( 29911422 )
2018
13
Idiopathic intracranial hypertension and bariatric surgery: a literature review and a presentation of two cases. ( 29385843 )
2018
14
Idiopathic intracranial hypertension: consensus guidelines on management. ( 29903905 )
2018
15
CTA/V detection of bilateral sigmoid sinus dehiscence and suspected idiopathic intracranial hypertension in unilateral pulsatile tinnitus. ( 29417173 )
2018
16
Noninvasive Assessment of Intracranial Pressure Status in Idiopathic Intracranial Hypertension Using Displacement Encoding with Stimulated Echoes (DENSE) MRI: A Prospective Patient Study with Contemporaneous CSF Pressure Correlation. ( 29284598 )
2018
17
Headache frequency and symptoms of depression as predictors of disability in patients with idiopathic intracranial hypertension. ( 29904836 )
2018
18
Long-term visual outcome in a Danish population of patients with idiopathic intracranial hypertension. ( 29405582 )
2018
19
Intracranial hypertension and cerebral autoregulation: a systematic review and meta-analysis. ( 29421451 )
2018
20
Complications of Optic Nerve Sheath Fenestration as a Treatment for Idiopathic Intracranial Hypertension. ( 29420144 )
2018
21
Anatomic measurements of cerebral venous sinuses in idiopathic intracranial hypertension patients. ( 29856739 )
2018
22
Characterising the patient experience of diagnostic lumbar puncture in idiopathic intracranial hypertension: a cross-sectional online survey. ( 29848770 )
2018
23
Intracranial fluid dynamics changes in idiopathic intracranial hypertension: pre and post therapy. ( 29807514 )
2018
24
Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension. ( 29298687 )
2018
25
Transverse venous stenting for the treatment of idiopathic intracranial hypertension, or pseudotumor cerebri. ( 29961386 )
2018
26
Treatment of idiopathic intracranial hypertension via stereotactic placement of biventriculoperitoneal shunts. ( 29393752 )
2018
27
Transverse venous sinus stenting for idiopathic intracranial hypertension: Safety and feasibility. ( 29882475 )
2018
28
Bilateral Venous Sinus Stenosis: Idiopathic Intracranial Hypertension and Endovascular Venous Sinus Stenting: 2-Dimensional Operative Video. ( 29444263 )
2018
29
Electroretinography in idiopathic intracranial hypertension: comparison of the pattern ERG and the photopic negative response. ( 29139045 )
2018
30
Analysis of petrous apex meningocele associated with meningioma: is there any relation with chronic intracranial hypertension? ( 29188303 )
2018
31
The utility of the lumbar puncture in idiopathic intracranial hypertension. ( 29973055 )
2018
32
Rapid effect of depletive lumbar puncture on papilledema in intracranial hypertension. ( 29903588 )
2018
33
Venous sinus stenting lowers the intracranial pressure in patients with idiopathic intracranial hypertension. ( 29871989 )
2018
34
Idiopathic intracranial hypertension as a presenting sign of adrenal insufficiency. ( 29375882 )
2018
35
Understanding the complex pathophysiology of idiopathic intracranial hypertension and the evolving role of venous sinus stenting: a comprehensive review of the literature. ( 29961379 )
2018
36
Unexpected occlusion of the contralateral transverse sinus after stenting for idiopathic intracranial hypertension. ( 29976107 )
2018
37
Inflammatory gene expression signatures in idiopathic intracranial hypertension: possible implications in microgravity-induced ICP elevation. ( 29354685 )
2018
38
Pediatric Intracranial Hypertension: a Current Literature Review. ( 29441432 )
2018
39
Ultrasonography of the optic nerve: An effective and easy strategy for detecting intracranial hypertension. ( 29793657 )
2018
40
A 15-year review of secondary and tertiary optic nerve sheath fenestration for idiopathic intracranial hypertension. ( 29313398 )
2018
41
Outcomes of endoscopic optic nerve decompression in patients with idiopathic intracranial hypertension. ( 28383199 )
2017
42
Very Low Prevalence of Intracranial Hypertension in Trigonocephaly. ( 28027242 )
2017
43
Osteoblastoma Mimicking an Idiopathic Intracranial Hypertension Syndrome. ( 28553393 )
2017
44
Shunt Surgery in Idiopathic Intracranial Hypertension Aided by Electromagnetic Navigation. ( 28088808 )
2017
45
Temporary Lumbar Drain as Treatment for Pediatric Fulminant Idiopathic Intracranial Hypertension. ( 27787461 )
2017
46
Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study. ( 28874206 )
2017
47
Cardiovascular risk factors in Chiari malformation and idiopathic intracranial hypertension. ( 28523220 )
2017
48
Intravitreal Ranibizumab Injection in Peripapillary CNVM Related to Idiopathic Intracranial Hypertension. ( 28453165 )
2017
49
Chronic fatigue syndrome and idiopathic intracranial hypertension: Different manifestations of the same disorder of intracranial pressure? ( 28735654 )
2017
50
Decompressive craniectomy in the management of intracranial hypertension after traumatic brain injury: a systematic review and meta-analysis. ( 28821777 )
2017

Variations for Intracranial Hypertension

Expression for Intracranial Hypertension

Search GEO for disease gene expression data for Intracranial Hypertension.

Pathways for Intracranial Hypertension

Pathways related to Intracranial Hypertension according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 APOH F2 F3 F5 SERPINC1 SERPINE1
2
Show member pathways
11.99 F2 IL1B MTHFR SERPINE1 TNF
3
Show member pathways
11.98 F3 IL1B SERPINE1 TNF
4 11.92 AQP4 IL1B SSTR1 TNF
5
Show member pathways
11.76 F2 F3 F5 SERPINC1 SERPINE1
6 11.69 CXCL10 IL1B TNF
7 11.62 F3 IL1B SERPINE1 TNF
8 11.5 F2 F3 F5 SERPINC1 SERPINE1
9 11.32 CXCL10 IL1B TNF
10 11.1 AQP1 AQP4 CXCL10 IL1B TNF
11 11.04 IL1B MTHFR TNF
12 10.71 IL1B TNF

GO Terms for Intracranial Hypertension

Cellular components related to Intracranial Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.86 APOH AQP1 F2 F3 IL1B SERPINC1
2 extracellular region GO:0005576 9.61 APOH CXCL10 F2 F3 F5 IL1B
3 external side of plasma membrane GO:0009897 9.46 AQP4 CXCL10 F2 TNF
4 extracellular space GO:0005615 9.28 APOH CXCL10 F2 F3 F5 IL1B

Biological processes related to Intracranial Hypertension according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.91 CXCL10 F2 IL1B SERPINE1 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.87 CXCL10 F3 IL1B TNF
3 cellular response to lipopolysaccharide GO:0071222 9.81 CXCL10 SERPINE1 TNF
4 blood coagulation GO:0007596 9.8 F2 F3 F5 SERPINC1
5 platelet degranulation GO:0002576 9.77 APOH F5 SERPINE1
6 positive regulation of angiogenesis GO:0045766 9.71 AQP1 F3 IL1B SERPINE1
7 fibrinolysis GO:0042730 9.63 F2 SERPINE1
8 blood coagulation, intrinsic pathway GO:0007597 9.62 APOH F2
9 water transport GO:0006833 9.62 AQP1 AQP4
10 cell volume homeostasis GO:0006884 9.61 AQP1 SLC12A3
11 positive regulation of monocyte chemotaxis GO:0090026 9.61 CXCL10 SERPINE1
12 blood circulation GO:0008015 9.61 CXCL10 F5 MTHFR
13 negative regulation of lipid catabolic process GO:0050995 9.59 IL1B TNF
14 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 IL1B TNF
15 negative regulation of blood coagulation GO:0030195 9.58 APOH SERPINE1
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL1B TNF
17 multicellular organismal water homeostasis GO:0050891 9.55 AQP1 AQP4
18 positive regulation of chemokine biosynthetic process GO:0045080 9.54 IL1B TNF
19 regulation of establishment of endothelial barrier GO:1903140 9.52 IL1B TNF
20 positive regulation of interleukin-8 production GO:0032757 9.5 IL1B SERPINE1 TNF
21 positive regulation of fever generation GO:0031622 9.48 IL1B TNF
22 sequestering of triglyceride GO:0030730 9.46 IL1B TNF
23 positive regulation of blood coagulation GO:0030194 9.43 APOH F2 SERPINE1
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IL1B TNF
25 regulation of blood coagulation GO:0030193 9.33 APOH F2 SERPINC1
26 hemostasis GO:0007599 9.26 F2 F3 F5 SERPINC1
27 negative regulation of fibrinolysis GO:0051918 8.8 APOH F2 SERPINE1

Molecular functions related to Intracranial Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 water channel activity GO:0015250 9.26 AQP1 AQP4
2 heparin binding GO:0008201 9.26 APOH CXCL10 F2 SERPINC1
3 water transmembrane transporter activity GO:0005372 9.16 AQP1 AQP4
4 protease binding GO:0002020 8.92 F3 SERPINC1 SERPINE1 TNF

Sources for Intracranial Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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