MCID: INT075
MIFTS: 54

Intracranial Hypertension

Categories: Neuronal diseases

Aliases & Classifications for Intracranial Hypertension

MalaCards integrated aliases for Intracranial Hypertension:

Name: Intracranial Hypertension 12 54 55 44 15 17 72
Raised Intracranial Pressure 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9428
MeSH 44 D019586
NCIt 50 C84791
SNOMED-CT 68 28073009
UMLS 72 C0151740

Summaries for Intracranial Hypertension

NINDS : 54 Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating sounds within the head, closely mimic symptoms of large brain tumors.

MalaCards based summary : Intracranial Hypertension, also known as raised intracranial pressure, is related to brain edema and thrombocytosis, and has symptoms including vomiting, headache and papilledema. An important gene associated with Intracranial Hypertension is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Acetazolamide and Cisatracurium have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 A brain disease that is characterized by high pressure inside the skull, the brain tissue and cerebrospinal fluid, has symptom headache, has symptom vomiting, has symptom altered mental status, has symptom papilledema.

Related Diseases for Intracranial Hypertension

Diseases related to Intracranial Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 708)
# Related Disease Score Top Affiliating Genes
1 brain edema 31.3 IL1B AQP4 AQP1
2 thrombocytosis 30.7 SERPINC1 F3 F2
3 sagittal sinus thrombosis 30.7 SERPINC1 F5 F3 F2
4 acute respiratory distress syndrome 30.4 TNF IL1B F5
5 myelitis 30.4 TNF AQP4 APOH
6 neuritis 30.3 TNF IL1B AQP4
7 central pontine myelinolysis 30.3 AQP4 AQP1
8 migraine with or without aura 1 30.3 TNF MTHFR ATP1A2 APOH
9 adult respiratory distress syndrome 30.2 TNF SERPINE1 F2
10 transverse myelitis 30.2 TNF AQP4 APOH
11 demyelinating disease 30.1 TNF IL1B AQP4
12 toxic shock syndrome 30.1 TNF SERPINC1 IL1B
13 protein c deficiency 30.0 SERPINC1 MTHFR F5 F2
14 meningococcemia 30.0 SERPINE1 SERPINC1 IL1B F5
15 typhoid fever 30.0 TNF IL1B F2
16 rheumatic disease 29.9 TNF IL1B APOH
17 pulmonary edema 29.8 TNF NPPB IL1B F2
18 thrombophilia due to thrombin defect 29.8 SERPINE1 SERPINC1 MTHFR F5 F3 F2
19 peripheral vascular disease 29.8 SERPINE1 SERPINC1 F3 F2
20 sickle cell anemia 29.7 TNF MTHFR F2
21 eclampsia 29.7 TNF SERPINC1 MTHFR F2
22 thrombosis 29.7 SERPINE1 SERPINC1 MTHFR F5 F3 F2
23 purpura 29.7 TNF SERPINC1 F3 F2 APOH
24 severe pre-eclampsia 29.6 SERPINC1 F5 APOH ADIPOQ
25 nonarteritic anterior ischemic optic neuropathy 29.6 SERPINC1 MTHFR F5 F2
26 leptospirosis 29.6 TNF IL1B F2 AQP1
27 intracranial thrombosis 29.5 SERPINC1 MTHFR F5 F3 APOH
28 peritonitis 29.5 TNF IL1B F2 AQP1
29 nervous system disease 29.5 TNF IL1B AQP4
30 disseminated intravascular coagulation 29.5 SERPINE1 SERPINC1 F5 F3 F2
31 sleep apnea 29.4 TNF NPPB IL1B ADIPOQ
32 central retinal vein occlusion 29.4 SERPINC1 MTHFR F5 F2 APOH
33 thrombophilia 29.3 SERPINE1 SERPINC1 MTHFR F5 F3 F2
34 thrombophlebitis 29.3 SERPINE1 SERPINC1 MTHFR F5 F2 APOH
35 antiphospholipid syndrome 29.2 SERPINC1 MTHFR F5 F3 F2 APOH
36 proteasome-associated autoinflammatory syndrome 1 29.1 TNF IL1B ADIPOQ
37 protein s deficiency 29.0 SERPINC1 MTHFR F5 F3 F2 APOH
38 retinal vein occlusion 28.9 SERPINE1 SERPINC1 MTHFR F5 F2 APOH
39 thrombophilia due to activated protein c resistance 28.8 SERPINE1 SERPINC1 MTHFR F5 F3 F2
40 stroke, ischemic 28.5 SERPINE1 SERPINC1 MTHFR F5 F3 F2
41 cerebrovascular disease 28.4 TNF SERPINE1 MTHFR F5 F2 ADIPOQ
42 vascular disease 27.4 TNF SERPINE1 SERPINC1 MTHFR F5 F3
43 pre-eclampsia 27.4 SERPINE1 SERPINC1 MTHFR F5 F3 F2
44 intracranial hypertension, idiopathic 13.0
45 gapo syndrome 11.5
46 craniosynostosis 1 11.3
47 craniosynostosis 4 11.3
48 craniosynostosis 2 11.3
49 craniosynostosis 3 11.3
50 craniosynostosis 6 11.3

Graphical network of the top 20 diseases related to Intracranial Hypertension:



Diseases related to Intracranial Hypertension

Symptoms & Phenotypes for Intracranial Hypertension

Symptoms:

12
  • vomiting
  • headache
  • papilledema
  • altered mental status

UMLS symptoms related to Intracranial Hypertension:


bulging fontanelle

MGI Mouse Phenotypes related to Intracranial Hypertension:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.29 ADIPOQ AQP1 AQP4 ATP1A2 F2 F3
2 homeostasis/metabolism MP:0005376 10.28 ADIPOQ APOH AQP1 AQP4 ATP1A2 F2
3 growth/size/body region MP:0005378 10.2 ADIPOQ AQP1 AQP4 F2 F3 F5
4 behavior/neurological MP:0005386 10.15 ADIPOQ AQP1 AQP4 ATP1A2 F2 F3
5 hematopoietic system MP:0005397 10.13 ADIPOQ AQP1 AQP4 F2 F3 HSD11B1
6 immune system MP:0005387 10.02 ADIPOQ AQP4 F2 F3 HSD11B1 IL1B
7 integument MP:0010771 10.02 ADIPOQ ATP1A2 F2 F3 F5 HSD11B1
8 mortality/aging MP:0010768 9.97 ADIPOQ APOH AQP1 AQP4 ATP1A2 F2
9 liver/biliary system MP:0005370 9.8 ADIPOQ F5 HSD11B1 MTHFR SERPINC1 SERPINE1
10 nervous system MP:0003631 9.73 ADIPOQ AQP1 AQP4 ATP1A2 F2 F3
11 respiratory system MP:0005388 9.28 ADIPOQ AQP1 AQP4 ATP1A2 F2 F3

Drugs & Therapeutics for Intracranial Hypertension

Drugs for Intracranial Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 231)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
2
Cisatracurium Approved Phase 4 96946-41-7
3
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
4
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
5
Remifentanil Approved Phase 4 132875-61-7 60815
6
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
7
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
8
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
9
Isotretinoin Approved Phase 4 4759-48-2 5282379 5538
10
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
11
Racepinephrine Approved Phase 4 329-65-7 838
12
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
13
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
14
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
15 Natriuretic Agents Phase 4
16 diuretics Phase 4
17 Carbonic Anhydrase Inhibitors Phase 4
18 Neuromuscular Nondepolarizing Agents Phase 4
19 Neuromuscular Blocking Agents Phase 4
20 Neuromuscular Agents Phase 4
21 Cholinergic Agents Phase 4
22 Cholinergic Antagonists Phase 4
23 Central Nervous System Depressants Phase 4
24 Anticonvulsants Phase 4
25 Narcotics Phase 4
26 Analgesics Phase 4
27 Peripheral Nervous System Agents Phase 4
28 Analgesics, Opioid Phase 4
29 Hormones Phase 4
30 Anti-Arrhythmia Agents Phase 4
31 Calcium, Dietary Phase 4
32 calcium channel blockers Phase 4
33 Anesthetics, Local Phase 4
34 Sodium Channel Blockers Phase 4
35 Tocolytic Agents Phase 4
36 Diuretics, Potassium Sparing Phase 4
37 Dermatologic Agents Phase 4
38 Epinephryl borate Phase 4
39
Esmolol Approved Phase 3 103598-03-4, 81147-92-4 59768
40
Quinine Approved Phase 2, Phase 3 130-95-0 8549 3034034
41
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
42
Amphetamine Approved, Illicit, Investigational Phase 3 300-62-9 5826 3007
43
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
44
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
45
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3 5284371
46
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 1302 156391
47
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
48
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
49
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
50
Sevoflurane Approved, Vet_approved Phase 3 28523-86-6 5206

Interventional clinical trials:

(show top 50) (show all 206)
# Name Status NCT ID Phase Drugs
1 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents. A Controlled Randomized Study Versus Placebo Unknown status NCT02404779 Phase 4 cisatracurium besilate
2 Comparison of the Efficacy Between 20% Mannitol and 3% Hypertonic Saline, Given as a Bolus at the Beginning of Elective Supratentorial Craniotomy for Tumor Resection, in Favoring Cerebral Relaxation Evaluated by a Sub-dural Intracranial Pressure Measurement. Unknown status NCT01745081 Phase 4 20% mannitol bolus administration;Hypertonic saline 3% bolus administration
3 Effect of Single Dose of Tramadol on Extubation Response and Quality of Emergence(Cough and Nausea Vomiting) Following Supratentorial Intracranial Surgery Unknown status NCT02964416 Phase 4 Injection Tramadol
4 A Randomised Controlled Trial of the Effectiveness of Acetazolamide in Reducing Cerebrospinal Fluid Pressure for Patients Undergoing Thoracic-abdominal Aortic Repair Unknown status NCT01889498 Phase 4 Acetazolamide
5 Equimolar Doses of Mannitol and Hypertonic Saline in the Treatment of Elevated Intracranial Pressure Completed NCT00447018 Phase 4 20% mannitol;7.45% hypertonic saline solution
6 Correlation of Measured and Calculated Serum Osmolality During Mannitol or Hypertonic Saline Infusion in Patients After Craniotomy Completed NCT02037815 Phase 4 20% mannitol solution, 125 ml, IV infusion in 15 min;3.1% sodium chloride solution, 125 ml, IV infusion in 15 min
7 Effect of Intravenous Infusion of Lidocaine, Magnesium Sulphate and Remifentanil Perioperatively in Patients Undergoing Mastectomy: a Prospective, Randomized and Double-blind Study Completed NCT02309879 Phase 4 Remifentanil infusion;Lidocaine infusion;Magnesium sulphate infusion;Magnesium sulphate and Lidocaine infusion
8 Prospective Open-label Phase IV Trial to Investigate the Frequency of Optic Disc Swelling, Idiopathic Intracranial Hypertension and Dry Eye Symptoms Under Antiacne Medication Treatment Recruiting NCT02149615 Phase 4
9 Study of Nasal Brushing Collected OLFActory MUcosa Samples in the Diagnosis of Human Encephalopathies Recruiting NCT02951559 Phase 4
10 Compared Effects of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension Terminated NCT00795587 Phase 4 variation of mannitol dose
11 Accuracy of ShuntCheck and MRI in Detection of Shunt Obstruction in Patients Receiving Shunt Patency Test Withdrawn NCT00793416 Phase 4
12 Effect of Mannitol as Adjunct Therapy on the Clinical Outcome of Childhood Cerebral Malaria in Mulago Hospital: A Randomised Clinical Trial Unknown status NCT00113854 Phase 3 Mannitol
13 Scientific Research and Development of Innovative Evidence Based Non-invasive Brain Diagnostic and Monitoring Solutions for Neurological and Traumatic Brain Injury Patients Unknown status NCT02130219 Phase 2, Phase 3
14 Comparison of Esmolol and Dexmedetomidine on Sympathetic Control During Intracranial Procedures Unknown status NCT02563288 Phase 3 Esmolol;Dexmedetomidine
15 Randomized Trial of Erythropoietin to Prevent Death From Cerebral Impairment During Severe Malaria Unknown status NCT00697164 Phase 2, Phase 3 Placebo;Erythropoietin
16 An Open-label Study of Oral Minocycline for the Treatment of Patients With Co-occurring Opioid and Amphetamine-type Stimulant Dependence (COATS) Unknown status NCT02541500 Phase 3 Minocycline
17 A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
18 Randomized Double-Blind Placebo-Controlled Trial of Oral Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness. Completed NCT00664001 Phase 3
19 Effect of Preventive Sodium Lactate Infusion on Intracranial Hypertension in Severe Trauma Tic Brain Injury Completed NCT00995683 Phase 2, Phase 3 half molar sodium lactate;isotonic sodium chloride
20 Cerebral Perfusion Pressure Using Precedex and Other Sedatives Completed NCT01169467 Phase 3 Standard-of-Care plus Dexmedetomidine
21 Anesthesiological Strategies in Elective Craniotomy: Randomized, Equivalence, Open Trial Completed NCT00741351 Phase 3 Sevoflurane + Fentanyl;Sevoflurane + Remifentanyl;Propofol + Remifentanyl
22 The Impact of Ventricular Catheter Impregnated With Antimicrobial Agents on Infection in Patients With Ventricular Catheter: A Prospective Randomized Study Completed NCT00286104 Phase 3
23 Pilot Study of Early and Prolonged Hypothermia in Severe Traumatic Brain Injury in Children Completed NCT00282269 Phase 2, Phase 3
24 Double Blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the Efficacy of Repetitive Transcranial Magnetic Stimulation in Patients Victims of Landmines With Phantom Limb Pain Completed NCT01872481 Phase 3
25 Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients Study Protocol for a Multicenter Randomized Open-label Trial With Blinded Adjudication of Primary Outcome Recruiting NCT03143751 Phase 3 NaCl20% (Continuous hyperosmolar therapy)
26 Randomized Trial of Medical Therapy (MT) vs. MT Plus Optic Nerve Sheath Fenestration vs. MT Plus Ventriculoperitoneal Cerebrospinal Fluid Shunting in Subjects With Idiopathic Intracranial Hypertension and Moderate to Severe Visual Loss Recruiting NCT03501966 Phase 3 Acetazolamide
27 Transfusion Strategies in Acute Brain Injured Patients. A Prospective Multicenter Randomized Study. Recruiting NCT02968654 Phase 3
28 Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension. Terminated NCT00622570 Phase 3 Pentobarbital;thiopental
29 Normal Pressure Hydrocephalus Treatment by Acetazolamide Terminated NCT02163330 Phase 3 Acetazolamide;sugar pill
30 Mannitol Versus Hypertonic Saline to Treat Intracranial Hypertension After Severe Traumatic Brain Injury : a Comparative Study on the Effects on PtiO2 and Microdialysis Values Terminated NCT01028339 Phase 3 Hypertonic saline;Mannitol
31 Sodium-Lactate Versus Mannitol in the Treatment of Intracranial Hypertensive Episodes in Severe Traumatic Brain Injured Patients Terminated NCT00319345 Phase 2, Phase 3 Mannitol, Sodium-Lactate
32 Pediatric Traumatic Brain Injury Consortium: Hypothermia Terminated NCT00222742 Phase 3
33 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3 Mannitol;Hypertonic Saline
34 Phase II/III, Randomized, Clinical Trial of the Effects of Nutropin AQ® on Growth and Bone Metabolism in Children With MPS I, II, and VI and Short Stature Terminated NCT00748969 Phase 2, Phase 3 Somatropin (DNA origin)
35 Intraventricular Tissue Plasminogen Activator in the Management of Aneurysmal Subarachnoid Hemorrhage: a Randomized Controlled Pilot Study Unknown status NCT01098890 Phase 2 Tissue Plasminogen Activator;Placebo
36 Feasibility of Dexmedetomidine-based Sedation in Neurocritical Care Patients : a Pilot Study Unknown status NCT02252523 Phase 2 Dexmedetomidine
37 A Proof-of-concept Study to Assess the Effect of Recombinant Human Growth Hormone on the Size of the Replication-competent Viral Reservoir in HIV-infected Individuals on Suppressive Antiretroviral Therapy Unknown status NCT03091374 Phase 2 Somatotropin (Human)
38 Lowering Intracranial Pressure in Idiopathic Intracranial Hypertension: Assessing the Therapeutic Efficacy and Safety of an 11β-hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017). Phase II Study. Completed NCT02017444 Phase 2 AZD4017
39 7.2% NaCl in 6% Hydroxyethyl Starch Versus Placebo - Effect on Intracranial Pressure and Haemodynamics in Subarachnoidal Haemorrhage (SAH) Patients. Completed NCT00199706 Phase 2 7.2% NaCl in 6% hydroxyethyl starch solution
40 Dexamethasone in Cryptococcal Meningitis Completed NCT00000776 Phase 2 Flucytosine;Fluconazole;Amphotericin B;Dexamethasone
41 A Randomized Double Blind Placebo Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin (IVIG) in Children With Japanese Encephalitis in Nepal Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRel™ (batch 20081217)]
42 Intranasal Ketamine for Treatment of Acute Pain in the Emergency Department : A Randomized Controlled Trial Completed NCT03233035 Phase 2 Ketamine;Placebo
43 Phase 2, Randomized Clinical Trial of the Safety and Efficacy of Brain Tissue Oxygen Monitoring in the Management of Severe Traumatic Brain Injury. Completed NCT00974259 Phase 2
44 Phase 1/Phase 2, Single-Center, Controlled Study of the Effectiveness of Combined High Frequency Oscillation and Tracheal Gas Insufflation in Improving the Clinical Course of Patients With Severe Acute Respiratory Distress Syndrome Completed NCT00416260 Phase 1, Phase 2
45 The Effect of Single-dose Propofol Injection on Pain and Quality of Life in Chronic Daily Headache: a Randomized Double-blind Controlled Trial Completed NCT00228267 Phase 2 Propofol
46 Acetazolamide for Treating NPH in Shunt-candidates Patients: an Open Label Feasibility Trial Recruiting NCT03779594 Phase 2 Acetazolamide
47 Treatment of Suspected Cholelithiasis With Nitroglycerin: a Randomized, Prospective Double-blind Trial Recruiting NCT01715220 Phase 2 sublingual nitroglycerine
48 Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial) Recruiting NCT03354143 Phase 2 Standard Care;Intensive Treatment
49 An Open-label Non-randomized Phase IIa Trial to Evaluate Safety of Early Intervention in Asymptomatic Subarachnoid Neurocysticercosis Not yet recruiting NCT03950037 Phase 2 Albendazole
50 A Phase 2, Randomized, Double Blind, Placebo , Controlled Study To Evaluate The Administration of CN-105 In Participants With Acute Supratentorial Intracerebral Hemorrhage Not yet recruiting NCT03711903 Phase 2 Acetyl-Valine-Serine-Arginine-Arginine-Arginine-NH2 (Ac-VSRRR- NH2).;0.9% Sodium-chloride

Search NIH Clinical Center for Intracranial Hypertension

Inferred drug relations via UMLS 72 / NDF-RT 51 :


carbamide peroxide
Thiopental
Thiopental Sodium
Urea
UREA POWDER

Cochrane evidence based reviews: intracranial hypertension

Genetic Tests for Intracranial Hypertension

Anatomical Context for Intracranial Hypertension

MalaCards organs/tissues related to Intracranial Hypertension:

41
Brain, Liver, Testes, Bone, Pituitary, Pineal, Eye

Publications for Intracranial Hypertension

Articles related to Intracranial Hypertension:

(show top 50) (show all 9031)
# Title Authors PMID Year
1
Is It Safe To Use Frontofacial Monobloc Advancement and Cutting Guides on Adult Patients with Crouzon Syndrome? Introducing 2 Cases on 41- and 56-Year-Old Patients. 38
31152887 2019
2
Medulloblastomas in cerebellopontine angle: Epidemiology, clinical manifestations, imaging features, molecular analysis and surgical outcome. 38
31239198 2019
3
Utility of Magnetic Resonance Imaging Features for Improving the Diagnosis of Idiopathic Intracranial Hypertension Without Papilledema. 38
30829949 2019
4
GAPO syndrome with craniosynostosis and intracranial hypertension. 38
31230109 2019
5
Cerebrovascular reactivity is not associated with therapeutic intensity in adult traumatic brain injury: a CENTER-TBI analysis. 38
31240583 2019
6
From decompressive craniectomy to cranioplasty and beyond-a pediatric neurosurgery perspective. 38
31327037 2019
7
Obstructive Sleep Apnea in Neuro-Ophthalmology. 38
30300256 2019
8
Endoscopic Fourth Ventriculostomy: Suboccipital Transaqueductal Approach for Fenestration of Isolated Fourth Ventricle: Case Report and Technical Note. 38
31203068 2019
9
Infantile Optic Pathway Glioblastoma. 38
31158532 2019
10
Roles of neuroimage in toxic encephalopathy induced by 1, 2-Dichloroethane. 38
31319235 2019
11
Blood-Brain Barrier Dysfunction in Idiopathic Intracranial Hypertension. 38
31393574 2019
12
Cerebrospinal Fluid Removal for Idiopathic Intracranial Hypertension: Less Cerebrospinal Fluid Is Best. 38
30801442 2019
13
Letter to the Editor Regarding "Prediction of Early Intracranial Hypertension After Severe Traumatic Brain Injury: A Prospective Study". 38
31426262 2019
14
In Reply to the Letter to the Editor Regarding "Prediction of Early Intracranial Hypertension After Severe Traumatic Brain Injury: A Prospective Study". 38
31426263 2019
15
Papillary Tumor of the Pineal Region: Systematic Review and Analysis of Prognostic Factors. 38
30989225 2019
16
Optic canal size in idiopathic intracranial hypertension and asymmetric papilledema. 38
31176474 2019
17
Utility of Magnetic Resonance Imaging Features for Improving the Diagnosis of Idiopathic Intracranial Hypertension Without Papilledema: Response. 38
31219894 2019
18
Utility of Magnetic Resonance Imaging Features for Improving the Diagnosis of Idiopathic Intracranial Hypertension Without Papilledema: Comment. 38
31425437 2019
19
Peripapillary Vessel Density Measured by Optical Coherence Tomography Angiography in Idiopathic Intracranial Hypertension. 38
30601283 2019
20
Magnetic Resonance Imaging of Idiopathic Intracranial Hypertension: Before and After Treatment. 38
31430269 2019
21
Familial Intracranial Hypertension in 2 Brothers With PTEN Mutation: Expansion of the Phenotypic Spectrum. 38
31046523 2019
22
Aqueductal Developmental Venous Anomaly Presenting with Mimic Symptoms of Idiopathic Normal Pressure Hydrocephalus in an Elderly Patient: A Case Report. 38
31417837 2019
23
Pathogenesis of hydrocephalus in achondroplastic dwarfs: a review and presentation of a case followed for 22 years. 38
31227857 2019
24
Acetazolamide Mitigates Intracranial Pressure Spikes Without Affecting Functional Outcome After Experimental Hemorrhagic Stroke. 38
30225552 2019
25
Endovascular treatment of debilitating tinnitus secondary to cerebral venous sinus abnormalities: a literature review and technical illustration. 38
30872352 2019
26
Hypotympanic Sound Baffle for Amelioration of Pulsatile Tinnitus due to Carotid and Jugular Bulb Dehiscence. 38
31295200 2019
27
Using titanium mesh to replace the bone flap during decompressive craniectomy: A medical hypothesis. 38
31371088 2019
28
Choroid plexus papilloma of the third ventricle. A case report. 38
31401052 2019
29
Intracranial Hypertension After Spontaneous Intracerebral Hemorrhage: A Systematic Review and Meta-analysis of Prevalence and Mortality Rate. 38
30565090 2019
30
Manifestation of papilloedema secondary to intracranial hypertension following trabeculectomy in juvenile open angle glaucoma. 38
31358165 2019
31
Ammonia-induced brain edema requires macrophage and T cell expression of Toll-like receptor 9. 38
31401214 2019
32
Mastoiditis caused by intracranial venous sinus stenting in an idiopathic intracranial hypertension patient. 38
31190591 2019
33
Change in CSF Dynamics Responsible for ICP Elevation After Ischemic Stroke in Rats: a New Mechanism for Unexplained END? 38
31418164 2019
34
Value of computerized shunt infusion study in assessment of pediatric hydrocephalus shunt function-a two center cross-sectional study. 38
31372736 2019
35
Trocar assisted distal shunt tube insertion with intra-operative X-Ray confirmation. 38
30836022 2019
36
Transcranial Color-Coded Sonography for Monitoring Idiopathic Intracranial Hypertension. 38
30458558 2019
37
Intracranial Hemorrhage and Intracranial Hypertension. 38
31262419 2019
38
Cerebral syphilitic gumma masquerading as cerebral metastatic tumors: case report. 38
31370018 2019
39
Spontaneous cerebrospinal fluid rhinorrhoea and aspiration pneumonitis following initiation of continuous positive airway pressure treatment for obstructive sleep apnoea. 38
31139415 2019
40
OMMAYA RESERVOIR SYSTEM FOR THE TREATMENT OF CYSTIC CRANIOPHARYNGIOMAS: SURGICAL RESULTS IN A SERIES OF 11 ADULT PATIENTS AND REVIEW OF THE LITERATURE. 38
31400528 2019
41
Role of Resistivity Index Analysis in the Prediction of Hemodynamically Significant Venous Sinus Stenosis in Patient With Idiopathic Intracranial Hypertension. 38
31384935 2019
42
Intracranial Hypertension and Cerebral Perfusion Pressure Insults in Adult Hypertensive Intraventricular Hemorrhage: Occurrence and Associations With Outcome. 38
31162192 2019
43
Idiopathic intracranial hypertension: Are there predictors for visual outcome or recurrences? 38
31176933 2019
44
An Ultrasound Vibro-Elastography Technique for Assessing Papilledema. 38
31122813 2019
45
Optic nerve sheath diameter ultrasound: optic nerve growth curve and its application to detect intracranial hypertension in children. 38
31377281 2019
46
ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury. 38
31425734 2019
47
Central Nervous System Cryptococcal Infections in Non-HIV Infected Patients. 38
31382367 2019
48
Head of the Bed Down: Paradoxical Management for Paradoxical Herniation. 38
31403093 2019
49
Pheochromocytoma, paragangliomas, and pituitary adenoma: An unusual association in a patient with an SDHD mutation. Case report. 38
31348302 2019
50
Language Development, Hearing Loss, and Intracranial Hypertension in Children With TWIST1-Confirmed Saethre-Chotzen Syndrome. 38
31299755 2019

Variations for Intracranial Hypertension

Expression for Intracranial Hypertension

Search GEO for disease gene expression data for Intracranial Hypertension.

Pathways for Intracranial Hypertension

Pathways related to Intracranial Hypertension according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 SERPINE1 SERPINC1 F5 F3 F2 APOH
2
Show member pathways
12.58 SERPINC1 F5 F3 F2 ATP1A2
3
Show member pathways
11.95 TNF SERPINE1 IL1B F3
4
Show member pathways
11.89 TNF SERPINE1 MTHFR IL1B F2
5 11.82 TNF SERPINE1 ADIPOQ
6
Show member pathways
11.79 TNF IL1B F2
7 11.7 TNF IL1B AQP4 AQP1
8 11.56 TNF SERPINE1 IL1B F3
9
Show member pathways
11.56 SERPINE1 SERPINC1 F5 F3 F2
10 11.47 ATP1A2 AQP4 AQP1
11 11.16 SERPINE1 SERPINC1 F5 F3 F2
12 11.04 TNF MTHFR IL1B
13 10.68 TNF IL1B

GO Terms for Intracranial Hypertension

Cellular components related to Intracranial Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 TNF SERPINE1 SERPINC1 NPPB IL1B F5
2 collagen-containing extracellular matrix GO:0062023 9.55 SERPINE1 SERPINC1 F3 APOH ADIPOQ
3 extracellular space GO:0005615 9.32 TNF SERPINE1 SERPINC1 NPPB IL1B F5

Biological processes related to Intracranial Hypertension according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.83 SERPINC1 F5 F3 F2
2 platelet degranulation GO:0002576 9.82 SERPINE1 F5 APOH
3 positive regulation of protein phosphorylation GO:0001934 9.8 TNF IL1B F2 ADIPOQ
4 response to drug GO:0042493 9.78 MTHFR AQP1 ADIPOQ
5 cellular response to mechanical stimulus GO:0071260 9.77 IL1B ATP1A2 AQP1
6 positive regulation of angiogenesis GO:0045766 9.73 SERPINE1 IL1B F3 AQP1
7 water transport GO:0006833 9.65 AQP4 AQP1
8 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.64 TNF IL1B
9 positive regulation of glial cell proliferation GO:0060252 9.64 TNF IL1B
10 negative regulation of lipid catabolic process GO:0050995 9.63 TNF IL1B
11 blood coagulation, intrinsic pathway GO:0007597 9.63 F2 APOH
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 TNF IL1B
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 TNF IL1B
14 negative regulation of blood coagulation GO:0030195 9.61 SERPINE1 APOH
15 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.6 IL1B ADIPOQ
16 negative regulation of synaptic transmission GO:0050805 9.58 IL1B ADIPOQ
17 multicellular organismal water homeostasis GO:0050891 9.58 AQP4 AQP1
18 positive regulation of chemokine biosynthetic process GO:0045080 9.57 TNF IL1B
19 response to glucocorticoid GO:0051384 9.56 TNF ADIPOQ
20 regulation of establishment of endothelial barrier GO:1903140 9.55 TNF IL1B
21 positive regulation of neuroinflammatory response GO:0150078 9.54 TNF IL1B
22 positive regulation of fever generation GO:0031622 9.51 TNF IL1B
23 regulation of blood coagulation GO:0030193 9.5 SERPINC1 F2 APOH
24 sequestering of triglyceride GO:0030730 9.48 TNF IL1B
25 hemostasis GO:0007599 9.46 SERPINC1 F5 F3 F2
26 positive regulation of blood coagulation GO:0030194 9.43 SERPINE1 F2 APOH
27 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 TNF IL1B
28 chronic inflammatory response to antigenic stimulus GO:0002439 9.16 TNF
29 negative regulation of fibrinolysis GO:0051918 9.13 SERPINE1 F2 APOH
30 regulation of signaling receptor activity GO:0010469 9.07 SERPINE1
31 positive regulation of interleukin-8 production GO:0032757 8.92 TNF SERPINE1 IL1B ADIPOQ

Molecular functions related to Intracranial Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 water channel activity GO:0015250 9.16 AQP4 AQP1
2 protease binding GO:0002020 8.92 TNF SERPINE1 SERPINC1 F3
3 water transmembrane transporter activity GO:0005372 8.65 AQP1
4 protein binding GO:0005515 10.1 TNF SLC12A3 SERPINE1 SERPINC1 NPPB IL1B

Sources for Intracranial Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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