Intracranial Hypertension

Categories: Neuronal diseases

Aliases & Classifications for Intracranial Hypertension

MalaCards integrated aliases for Intracranial Hypertension:

Name: Intracranial Hypertension 12 53 54 43 15 17 71
Raised Intracranial Pressure 12


External Ids:

Disease Ontology 12 DOID:9428
MeSH 43 D019586
NCIt 49 C84791
SNOMED-CT 67 271719001
UMLS 71 C0151740

Summaries for Intracranial Hypertension

NINDS : 53 Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating sounds within the head, closely mimic symptoms of large brain tumors.

MalaCards based summary : Intracranial Hypertension, also known as raised intracranial pressure, is related to intracranial hypertension, idiopathic and papilledema, and has symptoms including vomiting, headache and papilledema. An important gene associated with Intracranial Hypertension is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Acetazolamide and Cisatracurium have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 A brain disease that is characterized by high pressure inside the skull, the brain tissue and cerebrospinal fluid, has symptom headache, has symptom vomiting, has symptom altered mental status, has symptom papilledema.

Related Diseases for Intracranial Hypertension

Diseases related to Intracranial Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 798)
# Related Disease Score Top Affiliating Genes
1 intracranial hypertension, idiopathic 34.3 SSTR1 SLC12A3 RBP4 F3 F2 AQP4
2 papilledema 32.3 SERPINC1 F3 F2 APOH
3 hydrocephalus 31.3 TWIST1 TNF PRL MTHFR AQP4 AQP1
4 brain edema 31.1 IL1B AQP4 AQP1
5 sleep apnea 31.1 TNF SERPINE1 IL1B ADIPOQ
6 optic nerve disease 31.1 TNF IL1B AQP4 AQP1
7 obstructive hydrocephalus 31.0 PRL AQP4 AQP1
8 hepatic coma 31.0 SERPINC1 F3 F2
9 sagittal sinus thrombosis 31.0 SERPINC1 F5 F3 F2
10 thrombophilia due to thrombin defect 31.0 SERPINE1 SERPINC1 MTHFR F5 F3 F2
11 abducens nerve disease 31.0 SERPINC1 PRL F2 AQP4
12 mastoiditis 31.0 SERPINC1 MTHFR F2
13 meningoencephalitis 30.9 TNF IL1B CXCL10
14 encephalitis 30.9 TNF IL1B CXCL10 AQP4
15 pulmonary edema 30.8 TNF SERPINC1 IL1B F2
16 hepatic encephalopathy 30.8 TNF F2 AQP4
17 migraine with or without aura 1 30.8 TNF PRL MTHFR IL1B F2 AQP4
18 bacterial meningitis 30.8 TNF IL1B AQP4
19 lateral sinus thrombosis 30.7 SERPINC1 MTHFR F3 F2
20 thrombocytosis 30.7 SERPINC1 IL1B F3 F2
21 compartment syndrome 30.7 TNF SERPINC1 F3 F2
22 thrombosis 30.5 SERPINE1 SERPINC1 MTHFR F9 F5 F3
23 intracranial sinus thrombosis 30.4 SERPINC1 MTHFR F3 F2
24 neuritis 30.4 TNF IL1B CXCL10 AQP4
25 meningococcemia 30.4 SERPINE1 SERPINC1 IL1B F5
26 myelitis 30.4 TNF MTHFR AQP4 APOH
27 transverse myelitis 30.4 TNF AQP4 APOH
28 viral encephalitis 30.4 TNF IL1B CXCL10
29 apnea, obstructive sleep 30.4 TNF IL1B ADIPOQ
30 adult respiratory distress syndrome 30.4 TNF SERPINE1 IL1B F2
31 toxic shock syndrome 30.3 TNF SERPINC1 IL1B F3
32 autoimmune disease 30.3 TNF IL1B CXCL10 AQP4 APOH
33 syphilis 30.3 TNF F2 APOH
34 respiratory failure 30.3 TNF IL1B F3 F2 CXCL10
35 retinal vascular disease 30.3 TNF MTHFR IL1B
36 purpura 30.3 TNF SERPINC1 F3 F2 APOH
37 cerebral artery occlusion 30.3 TNF IL1B AQP4
38 optic neuritis 30.3 TNF IL1B CXCL10 AQP4
39 nonarteritic anterior ischemic optic neuropathy 30.3 SERPINC1 MTHFR F5 F2 APOH
40 transient cerebral ischemia 30.3 MTHFR IL1B APOH
41 fibromyalgia 30.2 TNF PRL IL1B
42 demyelinating disease 30.2 TNF IL1B CXCL10 AQP4
43 thrombophilia 30.2 SERPINE1 SERPINC1 MTHFR F9 F5 F3
44 typhoid fever 30.2 TNF IL1B F2
45 severe pre-eclampsia 30.2 SERPINE1 SERPINC1 RBP4 F5 APOH ADIPOQ
46 exanthem 30.2 TNF IL1B F3 F2
47 body mass index quantitative trait locus 11 30.2 TNF SERPINE1 RBP4 PRL IL1B HSD11B1
48 factor viii deficiency 30.1 F9 F5 F3 F2
49 leptospirosis 30.1 TNF IL1B F2 AQP1
50 intracranial thrombosis 30.1 SERPINC1 MTHFR F5 F3 F2 APOH

Graphical network of the top 20 diseases related to Intracranial Hypertension:

Diseases related to Intracranial Hypertension

Symptoms & Phenotypes for Intracranial Hypertension


  • vomiting
  • headache
  • papilledema
  • altered mental status

UMLS symptoms related to Intracranial Hypertension:

bulging fontanelle

MGI Mouse Phenotypes related to Intracranial Hypertension:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.38 ADIPOQ AQP1 AQP4 CXCL10 F2 F3
2 homeostasis/metabolism MP:0005376 10.38 ADIPOQ APOH AQP1 AQP4 CXCL10 F2
3 growth/size/body region MP:0005378 10.23 ADIPOQ AQP1 AQP4 F2 F3 F5
4 hematopoietic system MP:0005397 10.21 ADIPOQ AQP1 AQP4 CXCL10 F2 F3
5 immune system MP:0005387 10.15 ADIPOQ AQP4 CXCL10 F2 F3 F9
6 mortality/aging MP:0010768 10.03 ADIPOQ APOH AQP1 AQP4 CXCL10 F2
7 integument MP:0010771 10.02 ADIPOQ F2 F3 F5 HSD11B1 IL1B
8 liver/biliary system MP:0005370 9.91 ADIPOQ F5 F9 HSD11B1 MTHFR PRL
9 nervous system MP:0003631 9.86 ADIPOQ AQP1 AQP4 CXCL10 F2 F3
10 respiratory system MP:0005388 9.23 ADIPOQ AQP1 AQP4 F2 F3 HSD11B1

Drugs & Therapeutics for Intracranial Hypertension

Drugs for Intracranial Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 196)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
Cisatracurium Approved Phase 4 96946-41-7
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
Isotretinoin Approved Phase 4 4759-48-2 5282379 5538
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Remifentanil Approved Phase 4 132875-61-7 60815
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
Racepinephrine Approved Phase 4 329-65-7 838
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
Norepinephrine Approved Phase 4 51-41-2 439260
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
17 diuretics Phase 4
18 Carbonic Anhydrase Inhibitors Phase 4
19 Neuromuscular Blocking Agents Phase 4
20 Anesthetics Phase 4
21 Anticonvulsants Phase 4
22 Narcotics Phase 4
23 Analgesics, Opioid Phase 4
24 Calcium, Dietary Phase 4
25 calcium channel blockers Phase 4
26 Anesthetics, Local Phase 4
27 Sodium Channel Blockers Phase 4
28 Anti-Arrhythmia Agents Phase 4
29 Diuretics, Potassium Sparing Phase 4
30 Tocolytic Agents Phase 4
31 Neurotransmitter Agents Phase 4
32 Hypnotics and Sedatives Phase 4
33 Liver Extracts Phase 4
34 Analgesics, Non-Narcotic Phase 4
35 Analgesics Phase 4
36 Vasoconstrictor Agents Phase 4
37 Epinephryl borate Phase 4
38 Adrenergic alpha-Agonists Phase 4
39 Adrenergic Agents Phase 4
40 Adrenergic Agonists Phase 4
Calcium Nutraceutical Phase 4 7440-70-2 271
Esmolol Approved Phase 3 103598-03-4, 81147-92-4 59768
Quinine Approved Phase 2, Phase 3 130-95-0 8549 3034034
Amphetamine Approved, Illicit, Investigational Phase 3 300-62-9 5826 3007
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 1302 156391
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3 5284371
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986

Interventional clinical trials:

(show top 50) (show all 227)
# Name Status NCT ID Phase Drugs
1 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents. A Controlled Randomized Study Versus Placebo Unknown status NCT02404779 Phase 4 cisatracurium besilate
2 Prospective Open-label Phase IV Trial to Investigate the Frequency of Optic Disc Swelling, Idiopathic Intracranial Hypertension and Dry Eye Symptoms Under Antiacne Medication Treatment Unknown status NCT02149615 Phase 4
3 Comparison of the Efficacy Between 20% Mannitol and 3% Hypertonic Saline, Given as a Bolus at the Beginning of Elective Supratentorial Craniotomy for Tumor Resection, in Favoring Cerebral Relaxation Evaluated by a Sub-dural Intracranial Pressure Measurement. Unknown status NCT01745081 Phase 4 20% mannitol bolus administration;Hypertonic saline 3% bolus administration
4 Effect of Single Dose of Tramadol on Extubation Response and Quality of Emergence(Cough and Nausea Vomiting) Following Supratentorial Intracranial Surgery Unknown status NCT02964416 Phase 4 Injection Tramadol
5 A Randomised Controlled Trial of the Effectiveness of Acetazolamide in Reducing Cerebrospinal Fluid Pressure for Patients Undergoing Thoracic-abdominal Aortic Repair Unknown status NCT01889498 Phase 4 Acetazolamide
6 Equimolar Doses of Mannitol and Hypertonic Saline in the Treatment of Elevated Intracranial Pressure Completed NCT00447018 Phase 4 20% mannitol;7.45% hypertonic saline solution
7 Correlation of Measured and Calculated Serum Osmolality During Mannitol or Hypertonic Saline Infusion in Patients After Craniotomy Completed NCT02037815 Phase 4 20% mannitol solution, 125 ml, IV infusion in 15 min;3.1% sodium chloride solution, 125 ml, IV infusion in 15 min
8 Effect of Intravenous Infusion of Lidocaine, Magnesium Sulphate and Remifentanil Perioperatively in Patients Undergoing Mastectomy: a Prospective, Randomized and Double-blind Study Completed NCT02309879 Phase 4 Remifentanil infusion;Lidocaine infusion;Magnesium sulphate infusion;Magnesium sulphate and Lidocaine infusion
9 Study of Nasal Brushing Collected OLFActory MUcosa Samples in the Diagnosis of Human Encephalopathies Recruiting NCT02951559 Phase 4
10 Use of HA 330-II for Hemofiltration in Patients With Acute Liver Failure as a Bridge to Liver Transplantation: Clinical Evaluation Protocol. Recruiting NCT04243655 Phase 4 Standard medical treatment (SMT)
11 Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome of Patients Undergoing Brain Tumor Exclusion Recruiting NCT04266665 Phase 4 Dexmedetomidine
12 Compared Effects of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension Terminated NCT00795587 Phase 4 variation of mannitol dose
13 Accuracy of ShuntCheck and MRI in Detection of Shunt Obstruction in Patients Receiving Shunt Patency Test Withdrawn NCT00793416 Phase 4
14 Effect of Mannitol as Adjunct Therapy on the Clinical Outcome of Childhood Cerebral Malaria in Mulago Hospital: A Randomised Clinical Trial Unknown status NCT00113854 Phase 3 Mannitol
15 Scientific Research and Development of Innovative Evidence Based Non-invasive Brain Diagnostic and Monitoring Solutions for Neurological and Traumatic Brain Injury Patients Unknown status NCT02130219 Phase 2, Phase 3
16 Comparison of Esmolol and Dexmedetomidine on Sympathetic Control During Intracranial Procedures Unknown status NCT02563288 Phase 3 Esmolol;Dexmedetomidine
17 Randomized Trial of Erythropoietin to Prevent Death From Cerebral Impairment During Severe Malaria Unknown status NCT00697164 Phase 2, Phase 3 Placebo;Erythropoietin
18 Multi-centre Prospective Randomised Trial of Early Decompressive Craniectomy in Patients With Severe Traumatic Brain Injury Unknown status NCT00155987 Phase 3
19 An Open-label Study of Oral Minocycline for the Treatment of Patients With Co-occurring Opioid and Amphetamine-type Stimulant Dependence (COATS) Unknown status NCT02541500 Phase 3 Minocycline
20 A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
21 Randomized Double-Blind Placebo-Controlled Trial of Oral Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness. Completed NCT00664001 Phase 3
22 Effect of Preventive Sodium Lactate Infusion on Intracranial Hypertension in Severe Trauma Tic Brain Injury Completed NCT00995683 Phase 2, Phase 3 half molar sodium lactate;isotonic sodium chloride
23 Cerebral Perfusion Pressure Using Precedex and Other Sedatives Completed NCT01169467 Phase 3 Standard-of-Care plus Dexmedetomidine
24 Anesthesiological Strategies in Elective Craniotomy: Randomized, Equivalence, Open Trial Completed NCT00741351 Phase 3 Sevoflurane + Fentanyl;Sevoflurane + Remifentanyl;Propofol + Remifentanyl
25 The Impact of Ventricular Catheter Impregnated With Antimicrobial Agents on Infection in Patients With Ventricular Catheter: A Prospective Randomized Study Completed NCT00286104 Phase 3
26 Pilot Study of Early and Prolonged Hypothermia in Severe Traumatic Brain Injury in Children Completed NCT00282269 Phase 2, Phase 3
27 Double Blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the Efficacy of Repetitive Transcranial Magnetic Stimulation in Patients Victims of Landmines With Phantom Limb Pain Completed NCT01872481 Phase 3
28 Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients Study Protocol for a Multicenter Randomized Open-label Trial With Blinded Adjudication of Primary Outcome Recruiting NCT03143751 Phase 3 NaCl20% (Continuous hyperosmolar therapy)
29 The Role of Optic Nerve Sheath Fenestration in Leukemic Patients Having Increased Intracranial Pressure Active, not recruiting NCT04431882 Phase 2, Phase 3
30 Effect of Molar Sodium Lactate Filling on Cerebral Hemodynamics in Patients With Severe Meningeal Hemorrhage Multicenter Randomized Study Not yet recruiting NCT04141371 Phase 3 Molar Sodium Lactate;physiological serum
31 Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension. Terminated NCT00622570 Phase 3 Pentobarbital;thiopental
32 Normal Pressure Hydrocephalus Treatment by Acetazolamide Terminated NCT02163330 Phase 3 Acetazolamide;sugar pill
33 Mannitol Versus Hypertonic Saline to Treat Intracranial Hypertension After Severe Traumatic Brain Injury : a Comparative Study on the Effects on PtiO2 and Microdialysis Values Terminated NCT01028339 Phase 3 Hypertonic saline;Mannitol
34 Randomized Trial of Medical Therapy (MT) vs. MT Plus Optic Nerve Sheath Fenestration vs. MT Plus Ventriculoperitoneal Cerebrospinal Fluid Shunting in Subjects With Idiopathic Intracranial Hypertension and Moderate to Severe Visual Loss Terminated NCT03501966 Phase 3 Acetazolamide
35 Sodium-Lactate Versus Mannitol in the Treatment of Intracranial Hypertensive Episodes in Severe Traumatic Brain Injured Patients Terminated NCT00319345 Phase 2, Phase 3 Mannitol, Sodium-Lactate
36 Pediatric Traumatic Brain Injury Consortium: Hypothermia Terminated NCT00222742 Phase 3
37 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3 Mannitol;Hypertonic Saline
38 Phase II/III, Randomized, Clinical Trial of the Effects of Nutropin AQ® on Growth and Bone Metabolism in Children With MPS I, II, and VI and Short Stature Terminated NCT00748969 Phase 2, Phase 3 Somatropin (DNA origin)
39 Treatment of Suspected Cholelithiasis With Nitroglycerin: a Randomized, Prospective Double-blind Trial Unknown status NCT01715220 Phase 2 sublingual nitroglycerine
40 Intraventricular Tissue Plasminogen Activator in the Management of Aneurysmal Subarachnoid Hemorrhage: a Randomized Controlled Pilot Study Unknown status NCT01098890 Phase 2 Tissue Plasminogen Activator;Placebo
41 Feasibility of Dexmedetomidine-based Sedation in Neurocritical Care Patients : a Pilot Study Unknown status NCT02252523 Phase 2 Dexmedetomidine
42 Lowering Intracranial Pressure in Idiopathic Intracranial Hypertension: Assessing the Therapeutic Efficacy and Safety of an 11β-hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017). Phase II Study. Completed NCT02017444 Phase 2 AZD4017
43 Effect of Salutatory Oral Prednisolone Dosing on Cancer Pain WHO Stepladder Analgesic Drug Protocol Completed NCT04162379 Phase 2 Oral tablet
44 Dexamethasone in Cryptococcal Meningitis Completed NCT00000776 Phase 2 Flucytosine;Fluconazole;Amphotericin B;Dexamethasone
45 7.2% NaCl in 6% Hydroxyethyl Starch Versus Placebo - Effect on Intracranial Pressure and Haemodynamics in Subarachnoidal Haemorrhage (SAH) Patients. Completed NCT00199706 Phase 2 7.2% NaCl in 6% hydroxyethyl starch solution
46 A Randomized Double Blind Placebo Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin (IVIG) in Children With Japanese Encephalitis in Nepal Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRel™ (batch 20081217)]
47 Phase 2, Randomized Clinical Trial of the Safety and Efficacy of Brain Tissue Oxygen Monitoring in the Management of Severe Traumatic Brain Injury. Completed NCT00974259 Phase 2
48 Intranasal Ketamine for Treatment of Acute Pain in the Emergency Department : A Randomized Controlled Trial Completed NCT03233035 Phase 2 Ketamine;Placebo
49 Phase 1/Phase 2, Single-Center, Controlled Study of the Effectiveness of Combined High Frequency Oscillation and Tracheal Gas Insufflation in Improving the Clinical Course of Patients With Severe Acute Respiratory Distress Syndrome Completed NCT00416260 Phase 1, Phase 2
50 The Effect of Single-dose Propofol Injection on Pain and Quality of Life in Chronic Daily Headache: a Randomized Double-blind Controlled Trial Completed NCT00228267 Phase 2 Propofol

Search NIH Clinical Center for Intracranial Hypertension

Inferred drug relations via UMLS 71 / NDF-RT 50 :

carbamide peroxide
Thiopental Sodium

Cochrane evidence based reviews: intracranial hypertension

Genetic Tests for Intracranial Hypertension

Anatomical Context for Intracranial Hypertension

MalaCards organs/tissues related to Intracranial Hypertension:

Brain, Liver, Testes, Bone, Pituitary, Pineal, Eye

Publications for Intracranial Hypertension

Articles related to Intracranial Hypertension:

(show top 50) (show all 9407)
# Title Authors PMID Year
Predictors of intracranial hypertension in children undergoing ICP monitoring after severe traumatic brain injury. 61
31970473 2020
Elevated intracranial pressure after head trauma can be suppressed by antisecretory factor-a pilot study. 61
32445122 2020
High-fidelity Training Model for Measurement of Dynamic Optic Nerve Sheath Diameter Using Transorbital Ultrasonography. 61
30829892 2020
Optic nerve ultrasonography in monitoring treatment efficacy in pediatric idiopathic intracranial hypertension. 61
31940057 2020
Percutaneous transforaminal endoscopic decompression for lumbar spinal stenosis with degenerative spondylolisthesis in the elderly. 61
32446122 2020
Evaluation of Ophthalmology Inpatients Consultation in a Nigerian Tertiary Eye Care Centre. 61
32476114 2020
Multinodular and vacuolating neuronal tumor associated with focal cortical dysplasia in a child with refractory epilepsy: a case report and brief review of literature. 61
31950248 2020
A new technique linking cognitive impairment to raised intracranial pressure in syndromic craniosynostosis. 61
32167158 2020
Intracranial hypertension and cortical thickness in syndromic craniosynostosis. 61
32060907 2020
Therapeutic Hypothermia in Critically Ill Patients: A Systematic Review and Meta-Analysis of High Quality Randomized Trials. 61
32355134 2020
B-cell lymphoma 2 (Bcl-2) gene is associated with intracranial hypertension after severe traumatic brain injury. 61
32515262 2020
Optic nerve sheath fenestration via a supero-medial eyelid skin crease approach for the treatment of idiopathic intracranial hypertension in a UK population. 61
32555545 2020
Idiopathic Intracranial Hypertension and Anemia: A Matched Case-Control Study. 61
31842147 2020
Brain Metastasis of Wilms Tumor in Adult. 61
32251828 2020
Innominate vein stenosis causing raised intracranial pressure and blindness. 61
32548364 2020
Decompressive craniectomy with scalp expansion graft using a temporary synthetic skin substitute in the pediatric population: case series and review of the literature. 61
31965291 2020
Spontaneous CSF Leaks and IIH: A Flawless Connection? An Experience With 167 Patients. 61
32557740 2020
Clinical and radiological risk factors of autograft cranioplasty resorption after decompressive craniectomy for traumatic brain injury. 61
32544731 2020
The Effect of Timing of Intracranial Pressure Monitor Placement in Patients with Severe Traumatic Brain Injury. 61
32504255 2020
Consensus-Based Management Protocol (CREVICE Protocol) for the Treatment of Severe Traumatic Brain Injury Based on Imaging and Clinical Examination for Use When Intracranial Pressure Monitoring Is Not Employed. 61
32013721 2020
Comparative Radiographic Factors Predicting Functional Outcome After Decompressive Craniectomy in Severe Traumatic Brain Injury. 61
32251815 2020
Effect of Respiratory Physiological Changes on Optic Nerve Sheath Diameter and Cerebral Oxygen Saturation in Patients With Acute Traumatic Brain Injury. 61
32555065 2020
Cardiac-gated intracranial elastance in a swine model of raised intracranial pressure: a novel method to assess intracranial pressure-volume dynamics. 61
32503002 2020
Biological basis of child health 4: an overview of the central nervous system and principles of neurological assessment. 61
32567285 2020
The role of opening CSF pressure in response to treatment for idiopathic intracranial hypertension (IIH). 61
32331944 2020
Enlargement of Dorello's Canal as a Novel Radiographic Marker of Idiopathic Intracranial Hypertension. 61
32499996 2020
Review: pathophysiology of intracranial hypertension and noninvasive intracranial pressure monitoring. 61
32576216 2020
Self-Reported Weight and Height Among Idiopathic Intracranial Hypertension Patients. 61
31842150 2020
Anticoagulation delay does not affect the functional outcome of cerebral venous thrombosis. 61
32554865 2020
Cerebrospinal Fluid Findings of 36 Adult Patients with Autism Spectrum Disorder. 61
32521749 2020
A retrospective regional study of aqueduct stenosis and fourth ventricle outflow obstruction in the paediatric complex neurofibromatosis type 1 population; Aetiology, clinical presentation and management. 61
32208299 2020
Improvement in ventriculomegaly following cervicomedullary decompressive surgery in children with achondroplasia and foramen magnum stenosis. 61
32525257 2020
Migraine or idiopathic intracranial hypertension: Magnetic resonance venography and magnetic resonance imaging findings. 61
32321358 2020
Update in Pediatric Pseudotumor Cerebri Syndrome. 61
32422670 2020
Perinatal encephalopathy, the syndrome of intracranial hypertension and associated diagnostic labels in the Commonwealth of Independent States: a systematic review. 61
32532707 2020
Optical coherence tomography of the optic nerve head before and after optic nerve sheath fenestration for idiopathic intracranial hypertension. 61
32185637 2020
Management of intracranial hypertension in patients with severe traumatic brain injury: Pay attention to the oxygen level. 61
32102038 2020
Mid-term assessment of transverse sinus stent patency in 104 patients treated for intracranial hypertension secondary to dural sinus stenosis. 61
32522787 2020
Cerebral Autoregulation Monitoring and Online Arden Syntax Clinical Decision Support for the Treatment of Intracranial Hypertension in Children with Traumatic Brain Injury. 61
32578562 2020
General Anesthesia Alters Intracranial Venous Pressures During Transverse Sinus Stenting. 61
32194272 2020
Incomplete Cushing's reflex in extracorporeal membrane oxygenation. 61
31856638 2020
Extracorporeal renal and liver support in pediatric acute liver failure. 61
32500250 2020
Upward vectors for osteogenic distraction treatment in secondary chronic intracranial hypertension in children undergoing scaphocephaly surgery: 2 cases reported. 61
31925509 2020
Bilateral Squamosal Suture Craniosynostosis Presenting with Abducens Nerve Palsy and Severe Papilledema. 61
32217173 2020
[Unilateral Transcranial Endoscopic Surgical Removal for Large Intraventricular Tumor Assisted by Contralateral Neuroendoscope]. 61
32572001 2020
Idiopathic Intracranial Hypertension: Contemporary Management and Endovascular Techniques. 61
32419730 2020
Reductions in bilateral transverse sinus pressure gradients with unilateral transverse venous sinus stenting for idiopathic intracranial hypertension. 61
32482835 2020
Spontaneous Skull Base Cerebrospinal Fluid Leaks and Their Relationship to Idiopathic Intracranial Hypertension. 61
32551921 2020
Central Venous Obstruction-Induced Intracranial Hypertension in Hemodialysis Patients: An Underrecognized Cause of Elevated Intracranial Pressure. 61
32392024 2020
Does pituitary compression/empty sella syndrome contribute to MRI-negative Cushing's disease? A single-institution experience. 61
32480375 2020

Variations for Intracranial Hypertension

Expression for Intracranial Hypertension

Search GEO for disease gene expression data for Intracranial Hypertension.

Pathways for Intracranial Hypertension

Pathways related to Intracranial Hypertension according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
12.65 SERPINC1 F9 F5 F3 F2
Show member pathways
4 11.97 TNF SSTR1 IL1B AQP4
6 11.67 TNF SERPINE1 IL1B F3
7 11.63 TNF IL1B CXCL10 AQP4 AQP1
Show member pathways
9 11.34 TNF IL1B CXCL10
10 11.26 SERPINE1 SERPINC1 F9 F5 F3 F2
11 11.07 TNF MTHFR IL1B
13 10.46 TNF PRL

GO Terms for Intracranial Hypertension

Cellular components related to Intracranial Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TNF SERPINE1 SERPINC1 RBP4 PRL IL1B
2 collagen-containing extracellular matrix GO:0062023 9.7 SERPINE1 SERPINC1 F9 F3 F2 APOH
3 extracellular space GO:0005615 9.44 TNF SERPINE1 SERPINC1 RBP4 PRL IL1B

Biological processes related to Intracranial Hypertension according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.92 SERPINC1 PRL F5 F2
2 cytokine-mediated signaling pathway GO:0019221 9.89 TWIST1 TNF IL1B F3 CXCL10
3 positive regulation of protein phosphorylation GO:0001934 9.88 TNF IL1B F2 ADIPOQ
4 cellular response to lipopolysaccharide GO:0071222 9.87 TNF SERPINE1 IL1B CXCL10
5 blood coagulation GO:0007596 9.85 SERPINC1 F9 F5 F3 F2
6 positive regulation of interleukin-6 secretion GO:2000778 9.72 TWIST1 TNF IL1B
7 negative regulation of endothelial cell proliferation GO:0001937 9.7 TNF PRL APOH
8 positive regulation of JAK-STAT cascade GO:0046427 9.65 TNF PRL F2
9 positive regulation of angiogenesis GO:0045766 9.65 TWIST1 SERPINE1 IL1B F3 AQP1
10 positive regulation of neuroinflammatory response GO:0150078 9.62 TNF IL1B
11 multicellular organismal water homeostasis GO:0050891 9.61 AQP4 AQP1
12 negative regulation of synaptic transmission GO:0050805 9.61 IL1B ADIPOQ
13 blood coagulation, intrinsic pathway GO:0007597 9.61 F9 F2 APOH
14 regulation of establishment of endothelial barrier GO:1903140 9.6 TNF IL1B
15 negative regulation of vascular wound healing GO:0061044 9.59 TNF SERPINE1
16 cellular water homeostasis GO:0009992 9.58 AQP4 AQP1
17 positive regulation of blood coagulation GO:0030194 9.58 SERPINE1 F2 APOH
18 positive regulation of fever generation GO:0031622 9.56 TNF IL1B
19 sequestering of triglyceride GO:0030730 9.54 TNF IL1B
20 regulation of blood coagulation GO:0030193 9.54 SERPINC1 F2 APOH
21 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 TNF IL1B
22 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.5 TWIST1 IL1B ADIPOQ
23 negative regulation of fibrinolysis GO:0051918 9.33 SERPINE1 F2 APOH
24 positive regulation of interleukin-8 production GO:0032757 9.26 TNF SERPINE1 IL1B ADIPOQ
25 hemostasis GO:0007599 9.02 SERPINC1 F9 F5 F3 F2

Molecular functions related to Intracranial Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 TNF IL1B CXCL10 ADIPOQ
2 heparin binding GO:0008201 9.26 SERPINC1 F2 CXCL10 APOH
3 protease binding GO:0002020 8.92 TNF SERPINE1 SERPINC1 F3

Sources for Intracranial Hypertension

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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