MCID: INT303
MIFTS: 52

Intracranial Hypertension, Idiopathic

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Intracranial Hypertension, Idiopathic

MalaCards integrated aliases for Intracranial Hypertension, Idiopathic:

Name: Intracranial Hypertension, Idiopathic 58 54
Pseudotumor Cerebri 58 12 77 54 55 60 56 45 15 17 74
Idiopathic Intracranial Hypertension 12 54 60
Benign Intracranial Hypertension 12 55 60
Iih 54 60
Benign Intracran. Hypt. 12

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive


HPO:

33
intracranial hypertension, idiopathic:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:11459
OMIM 58 243200
ICD9CM 36 348.2
MeSH 45 D011559
NCIt 51 C85035
SNOMED-CT 69 68267002
ICD10 34 G93.2
ICD10 via Orphanet 35 G93.2
UMLS via Orphanet 75 C0033845
Orphanet 60 ORPHA238624
MedGen 43 C0033845
UMLS 74 C0033845

Summaries for Intracranial Hypertension, Idiopathic

NIH Rare Diseases : 54 Idiopathic intracranial hypertension (IIH), formerly known as pseudotumor cerebri, is a condition that affects the brain. Pseudotumor cerebri literally translates to "false brain tumor." This term was used because symptoms of IIH resemble those of brain tumors depsite no tumor being present. Symptoms of IIH may include severe headache, nausea and vomiting, altered vision, and pulsating sounds within the head. A person with IIH may also have symptoms such as a stiff neck, back or arm pain, eye pain, and memory problems. If the condition remains untreated, permanent visual loss or blindness may develop. While the exact underlying cause of IIH is not known (idiopathic), it is likely due to high fluid pressure within the skull that is due to buildup, or poor absorption, of cerebrospinal fluid (CSF). IIH most often (but not always) occurs in young, overweight, females. When symptoms of intracranial pressure have an identifiable cause such as another underlying disease or medication, the condition is instead referred to as secondary IH. Treatment for IIH may include medications called carbonic anhydrase inhibitors to control the production of CSF. In some cases, weight loss may also be recommended. However, medications and/or weight loss are not effective in all cases. In severe cases that do not respond to medication and weight loss, surgery may be needed to relieve symptoms and/or preserve vision.

MalaCards based summary : Intracranial Hypertension, Idiopathic, also known as pseudotumor cerebri, is related to intracranial hypertension and papilledema, and has symptoms including neurologic symptoms An important gene associated with Intracranial Hypertension, Idiopathic is SSTR1 (Somatostatin Receptor 1), and among its related pathways/superpathways is Bile secretion. The drugs Doxycycline and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and eye, and related phenotypes are hypertension and increased intracranial pressure

NINDS : 55 Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating sounds within the head, closely mimic symptoms of large brain tumors.

Wikipedia : 77 Idiopathic intracranial hypertension (IIH), previously known as pseudotumor cerebri and benign... more...

Description from OMIM: 243200

Related Diseases for Intracranial Hypertension, Idiopathic

Diseases related to Intracranial Hypertension, Idiopathic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 277)
# Related Disease Score Top Affiliating Genes
1 intracranial hypertension 30.8 AQP1 AQP4 SSTR1
2 papilledema 30.3 OGG1 PCLO
3 communicating hydrocephalus 30.2 AQP4 OGG1
4 optic nerve disease 29.8 AQP4 OPN4
5 neuromyelitis optica 29.4 AQP1 AQP4
6 congenital disorder of glycosylation, type iih 12.5
7 empty sella syndrome 11.7
8 galactokinase deficiency 11.7
9 idiopathic infantile hypercalcemia 11.5
10 leukemia 10.4
11 lupus erythematosus 10.4
12 systemic lupus erythematosus 10.4
13 acute promyelocytic leukemia 10.4
14 hypothyroidism 10.3
15 lyme disease 10.3
16 xeroderma pigmentosum, variant type 10.3
17 rickets 10.2
18 hypervitaminosis a 10.2
19 adenoma 10.2
20 spontaneous intracranial hypotension 10.2
21 aplastic anemia 10.1
22 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.1
23 hypophosphatasia 10.1
24 pituitary adenoma 10.1
25 meningitis 10.1
26 chiari malformation 10.1
27 allergic hypersensitivity disease 10.1
28 hypertension, essential 10.1
29 facial paralysis 10.1
30 chronic fatigue syndrome 10.1
31 headache 10.1
32 neurofibromatosis, type ii 10.0
33 pseudopapilledema 10.0
34 thrombophilia due to thrombin defect 10.0
35 torticollis 10.0
36 ocular motor apraxia 10.0
37 panencephalitis, subacute sclerosing 10.0
38 leptin deficiency or dysfunction 10.0
39 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 10.0
40 hyperprolactinemia 10.0
41 arthritis 10.0
42 bipolar disorder 10.0
43 brain injury 10.0
44 hepatitis 10.0
45 traumatic brain injury 10.0
46 congenital hypothyroidism 10.0
47 inflammatory bowel disease 10.0
48 lymphoma 10.0
49 cysticercosis 10.0
50 branch retinal artery occlusion 10.0

Comorbidity relations with Intracranial Hypertension, Idiopathic via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Intracranial Hypertension, Idiopathic:



Diseases related to Intracranial Hypertension, Idiopathic

Symptoms & Phenotypes for Intracranial Hypertension, Idiopathic

Human phenotypes related to Intracranial Hypertension, Idiopathic:

33
# Description HPO Frequency HPO Source Accession
1 hypertension 33 HP:0000822
2 increased intracranial pressure 33 HP:0002516
3 papilledema 33 HP:0001085

Symptoms via clinical synopsis from OMIM:

58
H E E N T:
papilledema
pseudotumor cerebri
idiopathic intracranial hypertension

Clinical features from OMIM:

243200

UMLS symptoms related to Intracranial Hypertension, Idiopathic:


neurologic symptoms

GenomeRNAi Phenotypes related to Intracranial Hypertension, Idiopathic according to GeneCards Suite gene sharing:

27 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.55 IRF6
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.55 IRF6 OGG1 OPN4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.55 OGG1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.55 OGG1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.55 OPN4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.55 IRF6
7 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.55 IRF6
8 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.55 OGG1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.55 OGG1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.55 OGG1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.55 OGG1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.55 OPN4
13 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.55 IRF6
14 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.55 IRF6
15 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.55 OPN4

MGI Mouse Phenotypes related to Intracranial Hypertension, Idiopathic:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.5 AQP1 AQP4 IHH OGG1 OPN4 PCLO
2 hearing/vestibular/ear MP:0005377 9.46 AQP1 AQP4 IRF6 SH3PXD2B
3 vision/eye MP:0005391 9.17 AQP1 AQP4 IHH OPN4 RBP4 SH3PXD2B

Drugs & Therapeutics for Intracranial Hypertension, Idiopathic

Drugs for Intracranial Hypertension, Idiopathic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
2
Minocycline Approved, Investigational Phase 4,Phase 2 10118-90-8 5281021
3
Isotretinoin Approved Phase 4 4759-48-2 5282379 5538
4
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
5 Hormones Phase 4
6 Hormone Antagonists Phase 4
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
8 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
9 Anti-Infective Agents Phase 4,Phase 2
10 Dermatologic Agents Phase 4
11
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 156391 1302
12
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
13
Acetazolamide Approved, Vet_approved Phase 2, Phase 3,Phase 3 59-66-5 1986
14
Aspirin Approved, Vet_approved Phase 2, Phase 3,Not Applicable 50-78-2 2244
15
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3 5284371
16
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
17
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
18 Antipyretics Phase 2, Phase 3
19 Chlorpheniramine, phenylpropanolamine drug combination Phase 2, Phase 3
20 Platelet Aggregation Inhibitors Phase 2, Phase 3
21 Analgesics Phase 2, Phase 3
22 Fibrinolytic Agents Phase 2, Phase 3
23 Anticonvulsants Phase 2, Phase 3,Phase 3
24 Anti-Inflammatory Agents Phase 2, Phase 3
25 Peripheral Nervous System Agents Phase 2, Phase 3
26 Carbonic Anhydrase Inhibitors Phase 2, Phase 3,Phase 3
27 Antitussive Agents Phase 2, Phase 3
28 diuretics Phase 2, Phase 3,Phase 3
29 Analgesics, Opioid Phase 2, Phase 3
30 Natriuretic Agents Phase 2, Phase 3,Phase 3
31 Respiratory System Agents Phase 2, Phase 3
32 Narcotics Phase 2, Phase 3
33 Cyclooxygenase Inhibitors Phase 2, Phase 3
34 Antirheumatic Agents Phase 2, Phase 3
35 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
36 Analgesics, Non-Narcotic Phase 2, Phase 3
37 Central Nervous System Depressants Phase 2, Phase 3
38
Nicotinamide Approved, Investigational Phase 2 98-92-0 936
39
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
40
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
41 Nicotinic Acids Phase 2
42 Micronutrients Phase 2,Not Applicable
43 Trace Elements Phase 2,Not Applicable
44 Vitamin B Complex Phase 2
45 Vitamins Phase 2,Not Applicable
46 Vitamin B3 Phase 2
47 Vitamin B9 Phase 2
48 Folate Phase 2
49 Nutrients Phase 2,Not Applicable
50 Antiparasitic Agents Phase 2

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome Completed NCT00266656 Phase 4 Humatrope
2 Antiacne Medications Pseudotumor Cerebri Recruiting NCT02149615 Phase 4
3 ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) Patients Withdrawn NCT00793416 Phase 4
4 Idiopathic Intracranial Hypertension Treatment Trial Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
5 Surgical Idiopathic Intracranial Hypertension Treatment Trial Recruiting NCT03501966 Phase 3 Acetazolamide
6 Normal Pressure Hydrocephalus Treatment by Acetazolamide Terminated NCT02163330 Phase 3 Acetazolamide;sugar pill
7 Study the Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Optic Nerve Disease Unknown status NCT01834079 Phase 1, Phase 2
8 Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension. Completed NCT02017444 Phase 2 AZD4017
9 BPX-01 Minocycline Topical Gel in the Treatment of Acne Vulgaris Completed NCT02815332 Phase 2 BPX-01 1% Minocycline Topical Gel;BPX-01 2% Minocycline Topical Gel;BPX-01 Vehicle Topical Gel
10 Placebo Controlled Efficacy and Safety Study of CD2475/101 40 mg Tablets vs. Placebo and Doxycycline 100 mg Capsules Once Daily in the Treatment of Inflammatory Lesions of Acne Vulgaris Completed NCT01320033 Phase 2 CD2475/101 40 mg Tablets;Doxycycline 100 mg Capsules;Placebo Tablet, and Placebo Capsule
11 Acetazolamide for Treating NPH in Shunt-candidates Patients Recruiting NCT03779594 Phase 2 Acetazolamide
12 Venous Sinus Stenting for Idiopathic Intracranial Hypertension Refractory to Medical Therapy Recruiting NCT01407809 Phase 1
13 Stenting of Venous Sinus Stenosis for Medically Refractory Idiopathic Intracranial Hypertension Unknown status NCT02143258 Not Applicable
14 Magnetic Resonance Venography Pre- and Post-Treatment in Patients With Idiopathic Intracranial Hypertension Unknown status NCT02394067
15 OCT Imaging of Papilledema in Pediatric Idiopathic Intracranial Hypertension Unknown status NCT02665858 Not Applicable
16 Intracranial Pressure vs Percentage Body Fat Unknown status NCT03144297
17 Neurocognitive Outcome in Children Who Suffered From Idiopathic Increased Intracranial Hypertension (IIH) Unknown status NCT02857335 Not Applicable
18 Oxidative Stress, Low Grade Inflammation, Tissue Breakdown and Biomarkers in Cerebrospinal Fluid of A-T Unknown status NCT02285348 Not Applicable
19 The Role of Susceptibility to Thrombosis in the Pseudotumor Cerebri of Nephropathic Cystinosis: A Case-Control Study Completed NCT00071903
20 Quantitative D-dimer Level and Anticoagulant Therapy in Idiopathic Intracranial Hypertension Completed NCT03963336 Early Phase 1 LMWH;acetazolamide
21 High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM Completed NCT00388921 Not Applicable Vitamin A
22 Multifocal Chromatic Pupilloperimetry in Patients With Pseudotumor Cerebri and Healthy Subjects. Recruiting NCT03304314 Not Applicable
23 Venous Sinus Stenting With the River Stent in IIH Recruiting NCT03556085 Not Applicable
24 Astronaut Vision Issues in a Ground Analog Population: Polycystic Ovary Syndrome Recruiting NCT02896452
25 Evaluating Raised Intracranial Pressure Using MR Elastography Recruiting NCT03096743 Not Applicable
26 Relaxin in Multiple Sclerosis (MS) Recruiting NCT01909492
27 Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE) Recruiting NCT03373045
28 An RCT of Bariatric Surgery vs a Community Weight Loss Programme for the Sustained Treatment of IIH Active, not recruiting NCT02124486 Not Applicable
29 The Effects of MAP and EtCO2 on Venous Sinus Pressures Not yet recruiting NCT03867461 Not Applicable
30 Operative Procedures vs. Endovascular Neurosurgery for Untreated Pseudotumor Trial Not yet recruiting NCT02513914 Not Applicable
31 Prospective Measurement of Normal Venous Sinus Pressures Not yet recruiting NCT03948971 Not Applicable
32 Phenotypic and Functional Study of 4BL B Cells in Multiple Sclerosis (MS) Not yet recruiting NCT03796611
33 Axial Length and Central Corneal Thickness in Benign Intracranial Hypertension Terminated NCT02541994 Not Applicable
34 Comparison of Continuous Non-Invasive and Invasive Intracranial Pressure Measurement Terminated NCT01863381 Not Applicable
35 Disc Edema in Patients With Chronic Kidney Disease Withdrawn NCT00769834
36 Analysis of Translaminar Pressure Gradient Using Noninvasive Cerebrospinal Fluid Pressure Monitoring Withdrawn NCT02828891 Not Applicable

Search NIH Clinical Center for Intracranial Hypertension, Idiopathic

Cochrane evidence based reviews: pseudotumor cerebri

Genetic Tests for Intracranial Hypertension, Idiopathic

Anatomical Context for Intracranial Hypertension, Idiopathic

MalaCards organs/tissues related to Intracranial Hypertension, Idiopathic:

42
Brain, Pituitary, Eye, Bone, Ovary, Prostate, Liver

Publications for Intracranial Hypertension, Idiopathic

Articles related to Intracranial Hypertension, Idiopathic:

(show top 50) (show all 739)
# Title Authors Year
1
Non-Syndromic Craniosynostosis Mimicking Primary Pseudotumor Cerebri Syndrome. ( 30474204 )
2019
2
Epidural Blood Patch for Postdural Puncture Headache due to Lumboperitoneal Shunt Placement in a Patient With Pseudotumor Cerebri: A Case Report. ( 30272589 )
2019
3
In Pseudotumor Cerebri, Hormonal Contraception is Not Associated, and the Diagnosis Remains Idiopathic Intracranial Hypertension. ( 31014540 )
2019
4
Atypical Anti-MOG syndrome with aseptic meningoencephalitis and pseudotumor cerebri-like presentations. ( 30300850 )
2019
5
Prognostic value of JAK2V617F mutation in pseudotumor cerebri associated with cerebral venous sinus thrombosis. ( 30251405 )
2019
6
RE: "An Estimation of the Risk of Pseudotumor Cerebri Among Users of the Levonorgestrel Intrauterine Device". ( 30723528 )
2019
7
Association Between Cycline Antibiotic and Development of Pseudotumor Cerebri Syndrome. ( 30905802 )
2019
8
Demographics, clinical features, and response to conventional treatments in pediatric Pseudotumor Cerebri syndrome: a single-center experience. ( 31025099 )
2019
9
A case of bilateral fourth nerve palsy associated with pseudotumor cerebri syndrome. ( 31038553 )
2019
10
The Occipital Emissary Vein: A Possible Marker for Pseudotumor Cerebri. ( 31072972 )
2019
11
Nuances of Endovascular Treatment of Transverse/Sigmoid Sinus Stenosis With Stenting Venoplasty in a Patient With Pseudotumor Cerebri: 2-Dimensional Operative Video. ( 30060093 )
2019
12
Methotrexate-induced pseudotumor cerebri in a patient with juvenile idiopathic arthritis. ( 30083940 )
2019
13
Headache Characteristics in Children With Pseudotumor Cerebri Syndrome, Elevated Opening Pressure Without Papilledema, and Normal Opening Pressure: A Retrospective Cohort Study. ( 30137653 )
2018
14
Evidence of Diplopia in Children's Headache Drawings Helps to Differentiate Pseudotumor Cerebri From Migraine. ( 29413638 )
2018
15
Secondary intracranial hypertension (pseudotumor cerebri) presenting as post-traumatic headache in mild traumatic brain injury: a case series. ( 29230542 )
2018
16
Transverse venous stenting for the treatment of idiopathic intracranial hypertension, or pseudotumor cerebri. ( 29961386 )
2018
17
Pseudotumor cerebri in kaposiform lymphangiomatosis: a case report and pathogenetic hypothesis. ( 29654359 )
2018
18
Pseudotumor cerebri as the presentation of Lyme disease in a non-endemic area. ( 29602888 )
2018
19
Pseudotumor cerebri syndrome in a patient with narcolepsy type 1. ( 29195824 )
2018
20
Myelin oligodendrocyte glycoprotein-positive optic neuritis masquerading as pseudotumor cerebri at presentation. ( 29938337 )
2018
21
Pseudotumor cerebri and lung cancer-associated jugular vein thrombosis: Role of anatomical variations of torcular herophili. ( 30450429 )
2018
22
Pseudotumor cerebri syndrome in a pregnant woman with systemic lupus erythematous. ( 29809325 )
2018
23
Pseudotumor cerebri in childhood and adolescence: data from a specialized service. ( 30570018 )
2018
24
Bariatric surgery as a treatment for pseudotumor cerebri: case study and narrative review of the literature. ( 28562736 )
2018
25
Ocular ultrasound for monitoring pseudotumor cerebri syndrome. ( 29243006 )
2018
26
Magnetic resonance elastography to estimate brain stiffness: Measurement reproducibility and its estimate in pseudotumor cerebri patients. ( 29459315 )
2018
27
Laparoscopy in the management of lumboperitoneal shunt catheter in obese patients with pseudotumor cerebri. ( 29519994 )
2018
28
Reduced Suprathreshold Odor Identification in Patients with Pseudotumor Cerebri: A Non-Randomized Prospective Study. ( 29658205 )
2018
29
An Up to Date Review of Pseudotumor Cerebri Syndrome. ( 29721718 )
2018
30
Clinical and Prognostic Significance of Cerebrospinal Fluid Opening and Closing Pressures in Pediatric Pseudotumor Cerebri Syndrome. ( 29753572 )
2018
31
Bariatric surgery and its impact on pseudotumor cerebri: A case report. ( 29780918 )
2018
32
Pseudotumor Cerebri Syndrome with Resolution After Discontinuing High Vitamin A Containing Dietary Supplement: Case Report and Review. ( 29796052 )
2018
33
Pseudotumor cerebri syndrome (PCTS) - Losing sight in patients and doctors with regards to a growing epidemic. ( 29954644 )
2018
34
Valsalva-triggered pseudotumor cerebri syndrome: Case series and pathogenetic implications. ( 30021914 )
2018
35
Pseudotumor Cerebri Following Nexplanon® Implantation. ( 30034970 )
2018
36
Pseudotumor cerebri comorbid with meningioma: A review and case series. ( 30105128 )
2018
37
Pseudotumor Cerebri Syndrome is the Best Term for This Condition. ( 30501891 )
2018
38
Pseudotumor cerebri syndrome without cerebral venous sinus thrombosis in Behçet's disease. ( 29246633 )
2017
39
Normal Pressure Pseudotumor Cerebri: A Series of Six Patients. ( 27593779 )
2017
40
Medication-Related Pseudotumor Cerebri Syndrome. ( 27786584 )
2017
41
Probable pseudotumor cerebri complex in 25 children. Further support of a concept. ( 27825557 )
2017
42
Therapeutic approaches to pediatric pseudotumor cerebri: New insights from literature data. ( 27903844 )
2017
43
How high is a 'high' CSF opening pressure in paediatric pseudotumor cerebri? ( 28187821 )
2017
44
Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study. ( 28356250 )
2017
45
Is Pseudotumor Cerebri An Unusual Expression of Chiari Syndrome? A Case Report and Review of the Literature. ( 28537352 )
2017
46
Oral fluoroquinolones and risk of secondary pseudotumor cerebri syndrome: Nested case-control study. ( 28754842 )
2017
47
Chiari I malformation with underlying pseudotumor cerebri: Poor symptom relief following posterior decompression surgery. ( 28756364 )
2017
48
Treatment Response in Pediatric Patients With Pseudotumor Cerebri Syndrome. ( 28787297 )
2017
49
Pediatric Pseudotumor Cerebri Syndrome. ( 28806347 )
2017
50
Pediatric Pseudotumor Cerebri Syndrome: Diagnosis, Classification, and Underlying Pathophysiology. ( 28941525 )
2017

Variations for Intracranial Hypertension, Idiopathic

Expression for Intracranial Hypertension, Idiopathic

Search GEO for disease gene expression data for Intracranial Hypertension, Idiopathic.

Pathways for Intracranial Hypertension, Idiopathic

Pathways related to Intracranial Hypertension, Idiopathic according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.48 AQP1 AQP4

GO Terms for Intracranial Hypertension, Idiopathic

Biological processes related to Intracranial Hypertension, Idiopathic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 eye development GO:0001654 9.26 RBP4 SH3PXD2B
2 renal water homeostasis GO:0003091 9.16 AQP1 AQP4
3 water transport GO:0006833 8.96 AQP1 AQP4
4 multicellular organismal water homeostasis GO:0050891 8.62 AQP1 AQP4

Molecular functions related to Intracranial Hypertension, Idiopathic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 channel activity GO:0015267 9.16 AQP1 AQP4
2 water channel activity GO:0015250 8.96 AQP1 AQP4
3 water transmembrane transporter activity GO:0005372 8.62 AQP1 AQP4

Sources for Intracranial Hypertension, Idiopathic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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