IIH
MCID: INT303
MIFTS: 57

Intracranial Hypertension, Idiopathic (IIH)

Categories: Eye diseases, Neuronal diseases, Rare diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Intracranial Hypertension, Idiopathic

MalaCards integrated aliases for Intracranial Hypertension, Idiopathic:

Name: Intracranial Hypertension, Idiopathic 57 19
Pseudotumor Cerebri 57 11 19 52 58 75 53 43 14 16 71
Idiopathic Intracranial Hypertension 11 19 58 75
Benign Intracranial Hypertension 11 58 31
Iih 19 58

Characteristics:


Inheritance:

Autosomal recessive 57

Prevelance:

Idiopathic Intracranial Hypertension: 1-5/10000 (Europe) 58

Age Of Onset:

Idiopathic Intracranial Hypertension: Adult,Elderly 58

Classifications:

Orphanet: 58  
Rare neurological diseases


Summaries for Intracranial Hypertension, Idiopathic

GARD: 19 Idiopathic intracranial hypertension (IIH), formerly known as pseudotumor cerebri, is a condition that affects the brain. Pseudotumor cerebri literally translates to "false brain tumor." This term was used because symptoms of IIH resemble those of brain tumors depsite no tumor being present. Symptoms of IIH may include severe headache, nausea and vomiting, altered vision, and pulsating sounds within the head. A person with IIH may also have symptoms such as a stiff neck, back or arm pain, eye pain, and memory problems. While the exact underlying cause of IIH is not known (idiopathic), it is likely due to high fluid pressure within the skull that is due to buildup, or poor absorption, of cerebrospinal fluid (CSF). IIH most often (but not always) occurs in young, overweight, females. When symptoms of intracranial pressure have an identifiable cause such as another underlying disease or medication, the condition is instead referred to as secondary IH.

MalaCards based summary: Intracranial Hypertension, Idiopathic, also known as pseudotumor cerebri, is related to intracranial hypertension and keratomalacia, and has symptoms including neurologic symptoms An important gene associated with Intracranial Hypertension, Idiopathic is SSTR1 (Somatostatin Receptor 1), and among its related pathways/superpathways are Metabolism and Adipogenesis. The drugs Lymecycline and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and spinal cord, and related phenotypes are increased intracranial pressure and obesity

NINDS: 52 Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating sounds within the head, closely mimic symptoms of large brain tumors.

Orphanet: 58 Idiopathic intracranial hypertension is a neurological disorder characterized by isolated increased intracranial pressure manifesting with recurrent and persistent headaches, nausea, vomiting, progressive and transient obstruction of the visual field, papilledema. Visual loss can be irreversible.

Wikipedia: 75 Idiopathic intracranial hypertension (IIH), previously known as pseudotumor cerebri and benign... more...

More information from OMIM: 243200

Related Diseases for Intracranial Hypertension, Idiopathic

Diseases related to Intracranial Hypertension, Idiopathic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 691)
# Related Disease Score Top Affiliating Genes
1 intracranial hypertension 31.8 POMC HSD11B1 AQP4 AQP1
2 keratomalacia 31.0 RBP4 RARA
3 abducens palsy 31.0 POMC MOG AQP4
4 acne 30.8 POMC LEP IGF1
5 cranial nerve palsy 30.7 POMC MOG AQP4
6 nonarteritic anterior ischemic optic neuropathy 30.6 OPN4 MOG AQP4
7 optic nerve disease 30.5 OPN4 MOG AQP4 AQP1
8 internuclear ophthalmoplegia 30.5 MOG AQP4
9 neurosarcoidosis 30.4 MOG AQP4
10 functioning pituitary adenoma 30.4 SSTR1 POMC IGF1
11 leptin deficiency or dysfunction 30.4 RBP4 POMC LEP IGF1
12 migraine with or without aura 1 30.3 POMC OPN4 LEP AQP4
13 hyperthyroidism 30.3 POMC LEP IGF1
14 intraocular pressure quantitative trait locus 30.3 OPN4 CA2 AQP4 AQP1
15 conn's syndrome 30.3 POMC LEP IGF1 HSD11B1
16 optic papillitis 30.3 MOG AQP4
17 brachial plexus neuritis 30.2 MOG AQP4
18 eating disorder 30.2 POMC LEP IGF1
19 adult syndrome 30.2 POMC LEP IGF1
20 apnea, obstructive sleep 30.2 POMC LEP IGF1
21 neuromyelitis optica 30.1 MOG AQP4 AQP1
22 fibromyalgia 30.1 POMC LEP IGF1
23 hypopituitarism 30.0 POMC LEP IGF1 HSD11B1
24 nutritional deficiency disease 30.0 RBP4 LEP IGF1
25 pituitary gland disease 30.0 SSTR1 POMC IGF1
26 central precocious puberty 30.0 POMC LEP IGF1
27 hyperandrogenism 30.0 POMC IGF1 HSD11B1
28 amenorrhea 29.9 POMC LEP IGF1
29 miller fisher syndrome 29.9 MOG AQP4
30 prolactinoma 29.9 SSTR1 POMC IGF1
31 lipoid congenital adrenal hyperplasia 29.8 POMC LEP IGF1 HSD11B1
32 polycystic ovary syndrome 29.8 POMC LEP IGF1 HSD11B1
33 sleep disorder 29.8 POMC OPN4 MOG LEP IGF1
34 gestational diabetes 29.7 RBP4 LEP IGF1
35 lipid metabolism disorder 29.7 RBP4 POMC LEP IGF1 HSD11B1
36 peripheral nervous system disease 29.5 POMC MOG LEP IGF1 AQP4
37 eye disease 29.5 RBP4 POMC OPN4 IGF1 CA2 AQP4
38 cataract 29.3 LEP IGF1 GALK1 AQP4 AQP1
39 congenital disorder of glycosylation, type iih 11.7
40 empty sella syndrome 11.3
41 galactosemia ii 11.2
42 papilledema 11.1
43 idiopathic infantile hypercalcemia 11.0
44 headache 10.7
45 hydrocephalus 10.6
46 acute promyelocytic leukemia 10.5
47 3-methylglutaconic aciduria, type iii 10.5
48 systemic lupus erythematosus 10.5
49 hypothyroidism 10.5
50 thrombosis 10.5

Comorbidity relations with Intracranial Hypertension, Idiopathic via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Intracranial Hypertension, Idiopathic:



Diseases related to Intracranial Hypertension, Idiopathic

Symptoms & Phenotypes for Intracranial Hypertension, Idiopathic

Human phenotypes related to Intracranial Hypertension, Idiopathic:

58 30 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 increased intracranial pressure 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002516
2 obesity 58 30 Frequent (33%) Frequent (79-30%)
HP:0001513
3 papilledema 58 30 Frequent (33%) Frequent (79-30%)
HP:0001085
4 allergy 58 30 Frequent (33%) Frequent (79-30%)
HP:0012393
5 sleep disturbance 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002360
6 diplopia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000651
7 photophobia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000613
8 vomiting 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002013
9 visual loss 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000572
10 abnormal emotion/affect behavior 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100851
11 nausea 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002018
12 scintillating scotoma 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0010822
13 blurred vision 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000622
14 depression 58 30 Very rare (1%) Very rare (<4-1%)
HP:0000716
15 back pain 58 30 Very rare (1%) Very rare (<4-1%)
HP:0003418
16 vertigo 58 30 Very rare (1%) Very rare (<4-1%)
HP:0002321
17 migraine 58 30 Very rare (1%) Very rare (<4-1%)
HP:0002076
18 lethargy 58 30 Very rare (1%) Very rare (<4-1%)
HP:0001254
19 pulsatile tinnitus 58 30 Very rare (1%) Very rare (<4-1%)
HP:0008629
20 focal sensory seizure with olfactory features 30 Very rare (1%) HP:0011161
21 hypertension 30 HP:0000822
22 headache 58 Very frequent (99-80%)
23 olfactory auras 58 Very rare (<4-1%)

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
H E E N T:
papilledema
pseudotumor cerebri
idiopathic intracranial hypertension

Clinical features from OMIM®:

243200 (Updated 08-Dec-2022)

UMLS symptoms related to Intracranial Hypertension, Idiopathic:


neurologic symptoms

MGI Mouse Phenotypes related to Intracranial Hypertension, Idiopathic:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.17 AQP1 AQP4 CA2 CA7 CA8 HSD11B1
2 homeostasis/metabolism MP:0005376 10.03 AQP1 AQP4 CA13 CA14 CA2 CA5B
3 renal/urinary system MP:0005367 9.86 AQP1 AQP4 CA2 IGF1 LEP POMC
4 respiratory system MP:0005388 9.5 AQP1 AQP4 CA2 HSD11B1 IGF1 LEP
5 vision/eye MP:0005391 9.32 AQP1 AQP4 CA14 GALK1 LEP MOG

Drugs & Therapeutics for Intracranial Hypertension, Idiopathic

Drugs for Intracranial Hypertension, Idiopathic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lymecycline Approved, Investigational Phase 4 992-21-2
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Minocycline Approved, Investigational Phase 4 10118-90-8, 13614-98-7 54675783 5281021
4
Isotretinoin Approved, Investigational, Nutraceutical Phase 4 302-79-4, 4759-48-2 5538 444795 5282379
5
Acetylsalicylic acid Approved, Vet_approved Phase 2, Phase 3 50-78-2 2244
6
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
7
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
8
Cathine Approved, Experimental, Illicit, Vet_approved, Withdrawn Phase 2, Phase 3 14838-15-4, 492-39-7 131954576 4786 26934
9
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
10
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3, 6854-40-6 5284371 5362471
11
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 156391 1302
12
Exenatide Approved, Investigational Phase 3 141758-74-9 45588096
13
Acetazolamide Approved, Vet_approved Phase 3 59-66-5, 1424-27-7 1986
14 Analgesics Phase 2, Phase 3
15 Antirheumatic Agents Phase 2, Phase 3
16 Fibrinolytic Agents Phase 2, Phase 3
17 Antipyretics Phase 2, Phase 3
18 Cyclooxygenase Inhibitors Phase 2, Phase 3
19 Platelet Aggregation Inhibitors Phase 2, Phase 3
20 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
21 Respiratory System Agents Phase 2, Phase 3
22 Antitussive Agents Phase 2, Phase 3
23 Analgesics, Opioid Phase 2, Phase 3
24 Anti-Inflammatory Agents Phase 2, Phase 3
25 Analgesics, Non-Narcotic Phase 2, Phase 3
26 Chlorpheniramine, phenylpropanolamine drug combination Phase 2, Phase 3
27 Narcotics Phase 2, Phase 3
28 Pharmaceutical Solutions Phase 3
29 Carbonic Anhydrase Inhibitors Phase 3
30 Anticonvulsants Phase 3
31 diuretics Phase 3
32
Heparin, bovine Approved, Investigational, Withdrawn 9005-49-6 22833565 9812414 772
33
Reviparin Approved, Investigational Early Phase 1 9041-08-1
34
Clopidogrel Approved 120202-66-6, 113665-84-2 60606
35 Calcium heparin
36 Fibrin fragment D Early Phase 1
37 Anticoagulants Early Phase 1
38 Heparin, Low-Molecular-Weight Early Phase 1
39 Anti-Bacterial Agents
40 Antibiotics, Antitubercular
41 Anesthetics
42 Hemostatics

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Prospective Open-label Phase IV Trial to Investigate the Frequency of Optic Disc Swelling, Idiopathic Intracranial Hypertension and Dry Eye Symptoms Under Antiacne Medication Treatment Unknown status NCT02149615 Phase 4
2 A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
3 A Phase III Randomised, Placebo-controlled, Double-blind, Multi-centre, Clinical Trial to Determine the Efficacy and Safety of Presendin in Idiopathic Intracranial Hypertension Recruiting NCT05347147 Phase 3 Presendin;Placebo
4 Randomized Trial of Medical Therapy (MT) vs. MT Plus Optic Nerve Sheath Fenestration vs. MT Plus Ventriculoperitoneal Cerebrospinal Fluid Shunting in Subjects With Idiopathic Intracranial Hypertension and Moderate to Severe Visual Loss Terminated NCT03501966 Phase 3 Acetazolamide
5 Lowering Intracranial Pressure in Idiopathic Intracranial Hypertension: Assessing the Therapeutic Efficacy and Safety of an 11β-hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017). Phase II Study. Completed NCT02017444 Phase 2 AZD4017
6 Venous Sinus Stenting for Idiopathic Intracranial Hypertension Refractory to Medical Therapy Completed NCT01407809 Phase 1
7 Assessment of Pupillary Response and Visual Field Defects by Objective Multifocal Chromatic Pupillometer in Patients With Pseudotumor Cerebri and Healthy Subjects Unknown status NCT03304314
8 Magnetic Resonance Venography Pre- and Post-Treatment in Patients With Idiopathic Intracranial Hypertension Unknown status NCT02394067
9 Assessment of Venous Drainage in Idiopathic Intracranial Hypertension Unknown status NCT04115553
10 Stenting of Venous Sinus Stenosis for Medically Refractory Idiopathic Intracranial Hypertension Unknown status NCT02143258
11 A Randomised Controlled Trial of Bariatric Surgery Versus a Community Weight Loss Programme for the Sustained Treatment of Idiopathic Intracranial Hypertension: the IIH:WT Trial Unknown status NCT02124486
12 OCT Imaging of Papilledema in Pediatric Idiopathic Intracranial Hypertension Unknown status NCT02665858
13 The Role of Susceptibility to Thrombosis in the Pseudotumor Cerebri of Nephropathic Cystinosis: A Case-Control Study Completed NCT00071903
14 Comparison of Optic Nerve Sheath Diameters Measured by Optic Ultrasonography Before and After Lumbar Puncture in Idiopathic Intracranial Hypertension Patients Completed NCT04603118
15 An Open-Label, Parallel, Randomized Study to Evaluate the Performance of Needle Placements for Diagnostic and Therapeutic Neuraxial Procedures, Using a Handheld Tactile Imaging-based Method Versus Palpation Completed NCT04796935
16 Post-Market Clinical Follow-up Registry of Patients With CODMAN CERTAS Plus Programmable Valves Completed NCT04207229
17 Prospective Measurement of Blood Pressure and End Tidal Carbon Dioxide Content Effects on Venous Sinus Caliber and Pressures in Patients With Idiopathic Intracranial Hypertension Undergoing Stenting Completed NCT03867461
18 D-dimer and the Use of Anticoagulation in IIH Completed NCT03963336 Early Phase 1 LMWH;acetazolamide
19 Assessment of ShuntCheck Performance Characteristics in Asymptomatic Patients With Pseudotumor Cerebri Recruiting NCT04309383
20 Randomized Controlled Trial Evaluating the Efficacy of Venous Sinus Stenting Versus Neurosurgical Internal Ventricular Shunt on Papillary Edema in the Management of Idiopathic Intracranial Hypertension Recruiting NCT05050864
21 Operative Procedures vs. Endovascular Neurosurgery for Untreated Pseudotumor Trial (OPEN-UP) Recruiting NCT02513914
22 Assessment of Raised Intracranial Pressure in Patients With Idiopathic Intracranial Hypertension by Optic Nerve Sheath Diameter and Transcranial Doppler Measurements Recruiting NCT04314128
23 Evaluating Raised Intracranial Pressure Using MR Elastography Recruiting NCT03096743
24 Diagnostic and Prognostic Biomarkers of Idiopathic Intracranial Hypertension Recruiting NCT04032379
25 Clinical Evaluation of the Serenity River Stent System to Treat Idiopathic Intracranial Hypertension Active, not recruiting NCT03556085
26 Astronaut Vision Issues and One Carbon Metabolism: Expanded Polymorphism Evaluation and Evaluation in a Potential Analog Population Active, not recruiting NCT02896452
27 Outcome of Cerebral Venous Sinuses Stenting on Idiopathic Intracranial Hypertension Enrolling by invitation NCT05308823
28 Post-Market Clinical Follow-up of Patients With CODMAN CERTAS Plus Programmable Valve Not yet recruiting NCT05397106
29 Comparison of Continuous Non-Invasive and Invasive Intracranial Pressure Measurement: Continuous Intracranial Pressure Monitoring Subprotocol Terminated NCT01863381
30 The Potential Value of Axial Length and Central Corneal Thickness in the Assessment for Risk of Permanent Optic Nerve Damage and Visual Field Loss in Benign Intracranial Hypertension Terminated NCT02541994

Search NIH Clinical Center for Intracranial Hypertension, Idiopathic

Cochrane evidence based reviews: pseudotumor cerebri

Genetic Tests for Intracranial Hypertension, Idiopathic

Anatomical Context for Intracranial Hypertension, Idiopathic

Organs/tissues related to Intracranial Hypertension, Idiopathic:

MalaCards : Brain, Eye, Spinal Cord, Pituitary, Bone Marrow, Temporal Lobe, Ovary

Publications for Intracranial Hypertension, Idiopathic

Articles related to Intracranial Hypertension, Idiopathic:

(show top 50) (show all 4215)
# Title Authors PMID Year
1
Expression of somatostatin receptors 1 and 2 in human choroid plexus and arachnoid granulations: implications for idiopathic intracranial hypertension. 53 62 57
12427069 2002
2
Vitamin A in the cerebrospinal fluid of patients with and without idiopathic intracranial hypertension. 62 57
12402264 2002
3
A familial coincidence of pseudotumor cerebri and communicating hydrocephalus. 62 57
1876253 1991
4
Familial benign intracranial hypertension. 62 57
932759 1976
5
Pseudotumor cerebri. Report of a familial occurrence. 62 57
4808492 1974
6
Papilledema and idiopathic intracranial hypertension. 62 57
5775633 1969
7
Serum and CSF vitamin A concentrations in idiopathic intracranial hypertension. 53 62
15955940 2005
8
Idiopathic Intracranial Hypertension and Vascular Anomalies in Chiari I Malformation. 62
36424059 2023
9
Visual outcomes in idiopathic intracranial hypertension in children. 62
34283970 2022
10
Familial idiopathic intracranial hypertension: a unique and rare entity with dramatic response to weight reduction. 62
34251614 2022
11
Surgical Management of Idiopathic Intracranial Hypertension in Pregnancy. 62
35833939 2022
12
MRI findings differentiating tonsillar herniation caused by idiopathic intracranial hypertension from Chiari I malformation. 62
35697809 2022
13
Positional Obstruction of Ventriculoperitoneal Shunt in a Patient With Idiopathic Intracranial Hypertension. 62
35483060 2022
14
Features of Idiopathic Intracranial Hypertension on MRI With MR Elastography: Prospective Comparison With Control Individuals and Assessment of Postintervention Changes. 62
35822642 2022
15
Intracranial computed tomography histogram analysis detects changes in the setting of elevated intracranial pressure and normal imaging. 62
35506947 2022
16
Literature Commentary. 62
36394969 2022
17
Headache characteristics among patients with epilepsy and the association with temporal encephaloceles. 62
36406872 2022
18
Imaging of the optic nerve: technological advances and future prospects. 62
36155662 2022
19
Comparison of the Range of Lumbar Cerebrospinal Fluid Pressure in Adults With Normal Cerebrospinal Fluid Pressure and in Idiopathic Intracranial Hypertension. 62
35427285 2022
20
Can Lumbar Puncture Be Safely Deferred in Patients With Mild Presumed Idiopathic Intracranial Hypertension? 62
34860748 2022
21
Phenotyping non-idiopathic pseudotumor cerebri syndrome - A prospective cohort study. 62
35983777 2022
22
Interdisciplinary Protocol for the Management of Vision-Threatening Papilledema. 62
35439211 2022
23
Multidisciplinary management of idiopathic intracranial hypertension in pregnancy: case series and narrative review. 62
33757747 2022
24
Idiopathic intracranial hypertension: Evaluation of births and fertility through the Hospital Episode Statistics dataset. 62
35620863 2022
25
Obstructive Sleep Apnea in Men With Idiopathic Intracranial Hypertension: A Prospective Case-Control Study. 62
36416758 2022
26
Evaluation of peripheral and central olfactory regions by MRI in patients with idiopathic intracranial hypertension. 62
36373831 2022
27
Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension. 62
36320018 2022
28
Case report: Meningoencephalocele and recurrent bacterial meningitis in chronic idiopathic intracranial hypertension. 62
36368955 2022
29
Pulmonary manifestations of childhood-onset primary Sjogren's syndrome (SS) masquerading as reactive airways disease in a male patient and review of interstitial lung disease associated with SS. 62
36384806 2022
30
Intracranial pressure and veins. 62
36134736 2022
31
Neuro-ophthalmological Presentation of Optic Neuritis in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. 62
35995144 2022
32
Neuroimaging in the diagnosis and treatment of intracranial pressure disorders. 62
36333629 2022
33
Venous Sinus Stenting: Safety and Health Care Resource Evaluation for Optimal Recovery in an Evolving Health Care Environment. 62
36334713 2022
34
The yield of ophthalmoscopy as a screening tool for intracranial pathology in pediatric headache. 62
36401633 2022
35
Effect of mannitol bolus administration on cerebrospinal fluid pressure in patients with idiopathic intracranial hypertension: a pilot study. 62
35752707 2022
36
Role of the glymphatic system in idiopathic intracranial hypertension. 62
36183631 2022
37
Expanding the clinical spectrum of idiopathic intracranial hypertension. 62
36444979 2022
38
Case Report of Idiopathic Intracranial Hypertension in Pregnancy. 62
35988696 2022
39
Venous Sinus Stenting for Low Pressure Gradient Stenoses in Idiopathic Intracranial Hypertension. 62
35960743 2022
40
[Idiopathic intracranial hypertension: From physiopathological mechanisms to therapeutic decision]. 62
36114039 2022
41
Technical and clinical success after venous sinus stenting for treatment of idiopathic intracranial hypertension using a novel guide catheter for access: Case series and initial multi-center experience. 62
36397725 2022
42
The ebb and flow of headache: A clue to pathophysiology of sinus stenosis in idiopathic intracranial hypertension? 62
36453388 2022
43
Evaluation of Magnetic Resonance Findings of Circumventricular Organs in Idiopathic Intracranial Hypertension Patients. 62
36425047 2022
44
Improving pediatric idiopathic intracranial hypertension care: a retrospective cohort study. 62
36357479 2022
45
Intra-procedural cerebral sinus thrombosis during endovascular treatment of idiopathic intracranial hypertension. 62
35488380 2022
46
Idiopathic Intracranial Hypertension and Endoscopic Optic Nerve Sheath Fenestration. 62
36452828 2022
47
Stenting versus medical treatment for idiopathic intracranial hypertension: a matched-control study. 62
36202600 2022
48
De Novo Presentation of Idiopathic Intracranial Hypertension (IIH) Associated With COVID-19 Infection. 62
36147772 2022
49
The idiopathic intracranial hypertension prospective cohort study: evaluation of prognostic factors and outcomes. 62
36242625 2022
50
Malignant Idiopathic Intracranial Hypertension. 62
36229275 2022

Variations for Intracranial Hypertension, Idiopathic

Expression for Intracranial Hypertension, Idiopathic

Search GEO for disease gene expression data for Intracranial Hypertension, Idiopathic.

Pathways for Intracranial Hypertension, Idiopathic

GO Terms for Intracranial Hypertension, Idiopathic

Biological processes related to Intracranial Hypertension, Idiopathic according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of tumor necrosis factor production GO:0032720 9.97 RARA POMC IGF1
2 cellular response to retinoic acid GO:0071300 9.93 RARA LEP AQP1
3 multicellular organismal water homeostasis GO:0050891 9.78 AQP4 AQP1
4 negative regulation of cartilage development GO:0061037 9.73 RARA LEP
5 cellular water homeostasis GO:0009992 9.71 AQP4 AQP1
6 bone mineralization involved in bone maturation GO:0035630 9.67 LEP IGF1
7 positive regulation of cellular pH reduction GO:0032849 9.62 CA2 CA7
8 regulation of chloride transport GO:2001225 9.56 CA7 CA2
9 one-carbon metabolic process GO:0006730 9.47 CA8 CA7 CA5B CA2 CA14 CA13
10 carbon dioxide transport GO:0015670 9.43 CA2 AQP4 AQP1
11 water homeostasis GO:0030104 9.33 AQP4 AQP1

Molecular functions related to Intracranial Hypertension, Idiopathic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 10.22 RARA CA8 CA7 CA5B CA2 CA14
2 hydro-lyase activity GO:0016836 9.8 CA8 CA7 CA5B CA2 CA14 CA13
3 arylesterase activity GO:0004064 9.67 CA2 CA1
4 lyase activity GO:0016829 9.63 CA1 CA13 CA14 CA2 CA5B CA7
5 cyanamide hydratase activity GO:0018820 9.56 CA2 CA1
6 carbonate dehydratase activity GO:0004089 9.47 CA8 CA7 CA5B CA2 CA14 CA13

Sources for Intracranial Hypertension, Idiopathic

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....