IIH
MCID: INT303
MIFTS: 52

Intracranial Hypertension, Idiopathic (IIH)

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Intracranial Hypertension, Idiopathic

MalaCards integrated aliases for Intracranial Hypertension, Idiopathic:

Name: Intracranial Hypertension, Idiopathic 57 53
Pseudotumor Cerebri 57 12 75 53 54 59 55 44 15 17 72
Benign Intracranial Hypertension 12 54 59 33
Idiopathic Intracranial Hypertension 12 53 59
Iih 53 59
Benign Intracran. Hypt. 12

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
intracranial hypertension, idiopathic:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:11459
OMIM 57 243200
ICD9CM 35 348.2
MeSH 44 D011559
NCIt 50 C85035
SNOMED-CT 68 68267002
ICD10 33 G93.2
ICD10 via Orphanet 34 G93.2
UMLS via Orphanet 73 C0033845
Orphanet 59 ORPHA238624
MedGen 42 C0033845
UMLS 72 C0033845

Summaries for Intracranial Hypertension, Idiopathic

NIH Rare Diseases : 53 Idiopathic intracranial hypertension (IIH), formerly known as pseudotumor cerebri, is a condition that affects the brain. Pseudotumor cerebri literally translates to "false brain tumor." This term was used because symptoms of IIH resemble those of brain tumors depsite no tumor being present. Symptoms of IIH may include severe headache, nausea and vomiting, altered vision, and pulsating sounds within the head. A person with IIH may also have symptoms such as a stiff neck, back or arm pain, eye pain, and memory problems. If the condition remains untreated, permanent visual loss or blindness may develop. While the exact underlying cause of IIH is not known (idiopathic), it is likely due to high fluid pressure within the skull that is due to buildup, or poor absorption, of cerebrospinal fluid (CSF). IIH most often (but not always) occurs in young, overweight, females. When symptoms of intracranial pressure have an identifiable cause such as another underlying disease or medication, the condition is instead referred to as secondary IH. Treatment for IIH may include medications called carbonic anhydrase inhibitors to control the production of CSF. In some cases, weight loss may also be recommended. However, medications and/or weight loss are not effective in all cases. In severe cases that do not respond to medication and weight loss, surgery may be needed to relieve symptoms and/or preserve vision.

MalaCards based summary : Intracranial Hypertension, Idiopathic, also known as pseudotumor cerebri, is related to papilledema and communicating hydrocephalus, and has symptoms including neurologic symptoms An important gene associated with Intracranial Hypertension, Idiopathic is SSTR1 (Somatostatin Receptor 1), and among its related pathways/superpathways is Bile secretion. The drugs Acetazolamide and Lymecycline have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related phenotypes are increased intracranial pressure and papilledema

NINDS : 54 Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating sounds within the head, closely mimic symptoms of large brain tumors.

Wikipedia : 75 Idiopathic intracranial hypertension (IIH), previously known as pseudotumor cerebri and benign... more...

More information from OMIM: 243200

Related Diseases for Intracranial Hypertension, Idiopathic

Diseases related to Intracranial Hypertension, Idiopathic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 492)
# Related Disease Score Top Affiliating Genes
1 papilledema 30.9 PCLO OGG1
2 communicating hydrocephalus 30.5 OGG1 AQP4
3 intracranial hypertension 30.2 SSTR1 SLC12A3 AQP4 AQP1
4 optic nerve disease 29.9 OPN4 AQP4
5 neuromyelitis optica 29.7 AQP4 AQP1
6 brain edema 29.3 AQP4 AQP1
7 congenital disorder of glycosylation, type iih 12.7
8 empty sella syndrome 11.8
9 galactokinase deficiency 11.8
10 idiopathic infantile hypercalcemia 11.6
11 hydrocephalus 10.5
12 congenital hydrocephalus 10.5
13 neurofibromatosis, type ii 10.5
14 xeroderma pigmentosum, variant type 10.5
15 acute promyelocytic leukemia 10.5
16 hypothyroidism 10.5
17 3-methylglutaconic aciduria, type iii 10.4
18 thrombosis 10.4
19 lupus erythematosus 10.4
20 systemic lupus erythematosus 10.4
21 hypervitaminosis a 10.4
22 deficiency anemia 10.4
23 thrombophilia due to thrombin defect 10.3
24 hydrops, lactic acidosis, and sideroblastic anemia 10.3
25 abducens nerve disease 10.3
26 lyme disease 10.3
27 chiari malformation 10.3
28 headache 10.3
29 hydrocephalus, congenital, 1 10.3
30 body mass index quantitative trait locus 11 10.3
31 body mass index quantitative trait locus 9 10.3
32 body mass index quantitative trait locus 8 10.3
33 body mass index quantitative trait locus 4 10.3
34 body mass index quantitative trait locus 10 10.3
35 body mass index quantitative trait locus 7 10.3
36 body mass index quantitative trait locus 12 10.3
37 body mass index quantitative trait locus 14 10.3
38 body mass index quantitative trait locus 18 10.3
39 body mass index quantitative trait locus 19 10.3
40 body mass index quantitative trait locus 20 10.3
41 iron deficiency anemia 10.3
42 iron metabolism disease 10.3
43 adenoma 10.3
44 meningitis 10.3
45 trichothiodystrophy 1, photosensitive 10.2
46 cockayne syndrome 10.2
47 sarcoidosis 1 10.2
48 ataxia and polyneuropathy, adult-onset 10.2
49 body mass index quantitative trait locus 1 10.2
50 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 10.2

Comorbidity relations with Intracranial Hypertension, Idiopathic via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Intracranial Hypertension, Idiopathic:



Diseases related to Intracranial Hypertension, Idiopathic

Symptoms & Phenotypes for Intracranial Hypertension, Idiopathic

Human phenotypes related to Intracranial Hypertension, Idiopathic:

59 32 (show all 22)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 increased intracranial pressure 59 32 Very frequent (99-80%) HP:0002516
2 papilledema 59 32 Frequent (79-30%) HP:0001085
3 obesity 59 Frequent (79-30%)
4 diplopia 59 Occasional (29-5%)
5 depressivity 59 Very rare (<4-1%)
6 hypertension 32 HP:0000822
7 sleep disturbance 59 Occasional (29-5%)
8 photophobia 59 Occasional (29-5%)
9 vomiting 59 Occasional (29-5%)
10 back pain 59 Very rare (<4-1%)
11 migraine 59 Very rare (<4-1%)
12 vertigo 59 Very rare (<4-1%)
13 visual loss 59 Occasional (29-5%)
14 headache 59 Very frequent (99-80%)
15 blurred vision 59 Occasional (29-5%)
16 lethargy 59 Very rare (<4-1%)
17 abnormal emotion/affect behavior 59 Occasional (29-5%)
18 nausea 59 Occasional (29-5%)
19 olfactory auras 59 Very rare (<4-1%)
20 allergy 59 Frequent (79-30%)
21 pulsatile tinnitus 59 Very rare (<4-1%)
22 scintillating scotoma 59 Occasional (29-5%)

Symptoms via clinical synopsis from OMIM:

57
H E E N T:
papilledema
pseudotumor cerebri
idiopathic intracranial hypertension

Clinical features from OMIM:

243200

UMLS symptoms related to Intracranial Hypertension, Idiopathic:


neurologic symptoms

MGI Mouse Phenotypes related to Intracranial Hypertension, Idiopathic:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.76 AQP1 AQP4 OGG1 OPN4 PEAR1 RBP4
2 cardiovascular system MP:0005385 9.73 AQP1 AQP4 IHH RBP4 SH3PXD2B SLC12A3
3 nervous system MP:0003631 9.5 AQP1 AQP4 IHH OGG1 OPN4 PCLO
4 vision/eye MP:0005391 9.17 AQP1 AQP4 IHH OPN4 RBP4 SH3PXD2B

Drugs & Therapeutics for Intracranial Hypertension, Idiopathic

Drugs for Intracranial Hypertension, Idiopathic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 106)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
2
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
3
Isotretinoin Approved Phase 4 4759-48-2 5282379 5538
4
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
5 diuretics Phase 4
6 Natriuretic Agents Phase 4
7 Anticonvulsants Phase 4
8 Carbonic Anhydrase Inhibitors Phase 4
9 Dermatologic Agents Phase 4
10
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
11
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
12
Amphetamine Approved, Illicit, Investigational Phase 3 300-62-9 5826 3007
13
Aspirin Approved, Vet_approved Phase 2, Phase 3 50-78-2 2244
14
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
15
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
16
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3 5284371
17
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 1302 156391
18
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
19
Mercaptopurine Approved Phase 3 50-44-2 667490
20
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
21
leucovorin Approved Phase 3 58-05-9 143 6006
22
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
23
Idarubicin Approved Phase 3 58957-92-9 42890
24
Arsenic trioxide Approved, Investigational Phase 3 1327-53-3 518740
25
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
26
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
27
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538 444795
28 Sympathomimetics Phase 3
29 Neurotransmitter Agents Phase 3
30 Central Nervous System Stimulants Phase 3
31 Adrenergic Agents Phase 3
32 Dopamine Agents Phase 3
33 Neurotransmitter Uptake Inhibitors Phase 3
34 Dopamine Uptake Inhibitors Phase 3
35 Autonomic Agents Phase 3
36 Folate Phase 3
37 Vitamin B9 Phase 3
38 Vitamin B Complex Phase 3
39 Anti-Bacterial Agents Phase 3
40 Anti-Infective Agents Phase 3
41 Antibiotics, Antitubercular Phase 3
42 Narcotics Phase 2, Phase 3
43 Analgesics, Non-Narcotic Phase 2, Phase 3
44 Cyclooxygenase Inhibitors Phase 2, Phase 3
45 Central Nervous System Depressants Phase 2, Phase 3
46 Fibrinolytic Agents Phase 2, Phase 3
47 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
48 Analgesics Phase 2, Phase 3
49 Peripheral Nervous System Agents Phase 2, Phase 3
50 Respiratory System Agents Phase 2, Phase 3

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 A Randomised Controlled Trial of the Effectiveness of Acetazolamide in Reducing Cerebrospinal Fluid Pressure for Patients Undergoing Thoracic-abdominal Aortic Repair Unknown status NCT01889498 Phase 4 Acetazolamide
2 Prospective Open-label Phase IV Trial to Investigate the Frequency of Optic Disc Swelling, Idiopathic Intracranial Hypertension and Dry Eye Symptoms Under Antiacne Medication Treatment Recruiting NCT02149615 Phase 4
3 Accuracy of ShuntCheck and MRI in Detection of Shunt Obstruction in Patients Receiving Shunt Patency Test Withdrawn NCT00793416 Phase 4
4 An Open-label Study of Oral Minocycline for the Treatment of Patients With Co-occurring Opioid and Amphetamine-type Stimulant Dependence (COATS) Unknown status NCT02541500 Phase 3 Minocycline
5 A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
6 Risk Adapted Treatment of Newly Diagnosed Childhood Acute Promyelocytic Leukemia (APL) Using Arsenic Trioxide (Trisenox® IND# 103, 331) During Consolidation Completed NCT00866918 Phase 3 arsenic trioxide;mitoxantrone hydrochloride;idarubicin;tretinoin;cytarabine;mercaptopurine tablet;methotrexate
7 Randomized Trial of Medical Therapy (MT) vs. MT Plus Optic Nerve Sheath Fenestration vs. MT Plus Ventriculoperitoneal Cerebrospinal Fluid Shunting in Subjects With Idiopathic Intracranial Hypertension and Moderate to Severe Visual Loss Recruiting NCT03501966 Phase 3 Acetazolamide
8 Normal Pressure Hydrocephalus Treatment by Acetazolamide Terminated NCT02163330 Phase 3 Acetazolamide;sugar pill
9 A Proof-of-concept Study to Assess the Effect of Recombinant Human Growth Hormone on the Size of the Replication-competent Viral Reservoir in HIV-infected Individuals on Suppressive Antiretroviral Therapy Unknown status NCT03091374 Phase 2 Somatotropin (Human)
10 Lowering Intracranial Pressure in Idiopathic Intracranial Hypertension: Assessing the Therapeutic Efficacy and Safety of an 11β-hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017). Phase II Study. Completed NCT02017444 Phase 2 AZD4017
11 A Randomized, Double-blind, Vehicle Controlled Study to Assess the Safety and Efficacy of BPX-01 Minocycline Topical Gel in the Treatment of Moderate to Severe Inflammatory Acne Vulgaris Completed NCT02815332 Phase 2 BPX-01 1% Minocycline Topical Gel;BPX-01 2% Minocycline Topical Gel;BPX-01 Vehicle Topical Gel
12 Evaluation of Effect of Doxycycline Verses Placebo on Diabetic Retinopathy Progression and Retinal Function in Patients With Severe Non-proliferative or Mild or Moderate (Non-high-risk) Proliferative Diabetic Retinopathy Completed NCT00511875 Phase 2 doxycycline monohydrate;placebo
13 The Effect of Single-dose Propofol Injection on Pain and Quality of Life in Chronic Daily Headache: a Randomized Double-blind Controlled Trial Completed NCT00228267 Phase 2 Propofol
14 Acetazolamide for Treating NPH in Shunt-candidates Patients: an Open Label Feasibility Trial Recruiting NCT03779594 Phase 2 Acetazolamide
15 PRISM: A Double Blind, Randomized, Vehicle Controlled Phase 2 Study to Assess the Safety and Efficacy of BPX-04 Minocycline Topical Gel in the Treatment of Inflammatory Lesions of Papulopustular Rosacea Active, not recruiting NCT03667222 Phase 2 minocycline topical gel;topical gel vehicle
16 Venous Sinus Stenting for Idiopathic Intracranial Hypertension Refractory to Medical Therapy Active, not recruiting NCT01407809 Phase 1
17 Evaluation of the Feasibility, Safety and Efficacy of Venous Stenting for Internal Jugular Vein Stenosis Not yet recruiting NCT03373292 Phase 1
18 OCT Imaging of Papilledema in Pediatric Idiopathic Intracranial Hypertension Unknown status NCT02665858
19 Magnetic Resonance Venography Pre- and Post-Treatment in Patients With Idiopathic Intracranial Hypertension Unknown status NCT02394067
20 Stenting of Venous Sinus Stenosis for Medically Refractory Idiopathic Intracranial Hypertension Unknown status NCT02143258
21 Correlation Between Intracranial Pressure as Measured by Lumbar Puncture Manometry and Percentage Body Fat as Measured by Air-displacement Plethysmography Unknown status NCT03144297
22 Tablet-guided Versus Freehand (Tab-Guide) Ventriculostomy : Study Protocol to the Test Accuracy of Ventriculostomy in a Randomized Controlled Trial Unknown status NCT02048553
23 D-dimer and the Use of Anticoagulation in IIH Completed NCT03963336 Early Phase 1 LMWH;acetazolamide
24 The Role of Susceptibility to Thrombosis in the Pseudotumor Cerebri of Nephropathic Cystinosis: A Case-Control Study Completed NCT00071903
25 Comparison of Continuous Noninvasive and Invasive Intracranial Pressure Measurement--Celda Infusion Subprotocol Completed NCT01976559
26 High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM Completed NCT00388921 Vitamin A
27 Effect of Preoperative Hospitalization Duration on Post-operative Cognitive Dysfunction in Patients Who Underwent Hip Surgery Under Regional Anesthesia Completed NCT03290599
28 Diagnostic and Prognostic Biomarkers of Idiopathic Intracranial Hypertension Recruiting NCT04032379
29 Prospective Measurement of Blood Pressure and End Tidal Carbon Dioxide Content Effects on Venous Sinus Caliber and Pressures in Patients With Idiopathic Intracranial Hypertension Undergoing Stenting Recruiting NCT03867461
30 Evaluating Raised Intracranial Pressure Using MR Elastography Recruiting NCT03096743
31 Assessment of Pupillary Response and Visual Field Defects by Objective Multifocal Chromatic Pupillometer in Patients With Pseudotumor Cerebri and Healthy Subjects Recruiting NCT03304314
32 Clinical Evaluation of the Serenity River Stent System to Treat Idiopathic Intracranial Hypertension Recruiting NCT03556085
33 Astronaut Vision Issues and One Carbon Metabolism: Expanded Polymorphism Evaluation and Evaluation in a Potential Analog Population Recruiting NCT02896452
34 Ocular and Vision Problems in Patients After Fontan Operation Recruiting NCT03170778
35 A Randomized Clinical Trial on the Efficacy and Cost-efficacy of Adding on a Mindfulness-based Therapy to Standard Medical Prophylaxis in the Treatment of Patients With Chronic Migraine Associated to Medication Overuse Following Structured Withdrawal: the Mind-CM Study Recruiting NCT03671681 Prophylactic
36 A Randomised Controlled Trial of Bariatric Surgery Versus a Community Weight Loss Programme for the Sustained Treatment of Idiopathic Intracranial Hypertension: the IIH:WT Trial Active, not recruiting NCT02124486
37 Operative Procedures vs. Endovascular Neurosurgery for Untreated Pseudotumor Trial (OPEN-UP) Not yet recruiting NCT02513914
38 Venous Sinus Pressures in Normal Individuals Not yet recruiting NCT03948971
39 The Potential Value of Axial Length and Central Corneal Thickness in the Assessment for Risk of Permanent Optic Nerve Damage and Visual Field Loss in Benign Intracranial Hypertension Terminated NCT02541994
40 Comparison of Continuous Non-Invasive and Invasive Intracranial Pressure Measurement: Continuous Intracranial Pressure Monitoring Subprotocol Terminated NCT01863381
41 Pilot Study of Acetazolamide to Prevent Post Operative Cerebrospinal Fluid (CSF) Leak in Patients Undergoing Endoscopic Skull Base Surgery Withdrawn NCT02902133 Acetazolamide
42 Incidence and Causes of Disc Edema in Patients With Chronic Kidney Disease Withdrawn NCT00769834
43 Analysis of Translaminar Pressure Gradient Using Noninvasive Cerebrospinal Fluid Pressure Monitoring Withdrawn NCT02828891

Search NIH Clinical Center for Intracranial Hypertension, Idiopathic

Cochrane evidence based reviews: pseudotumor cerebri

Genetic Tests for Intracranial Hypertension, Idiopathic

Anatomical Context for Intracranial Hypertension, Idiopathic

MalaCards organs/tissues related to Intracranial Hypertension, Idiopathic:

41
Brain, Eye, Testes, Pituitary, Liver, Kidney, Bone

Publications for Intracranial Hypertension, Idiopathic

Articles related to Intracranial Hypertension, Idiopathic:

(show top 50) (show all 1305)
# Title Authors PMID Year
1
Expression of somatostatin receptors 1 and 2 in human choroid plexus and arachnoid granulations: implications for idiopathic intracranial hypertension. 9 8
12427069 2002
2
A familial coincidence of pseudotumor cerebri and communicating hydrocephalus. 38 8
1876253 1991
3
Pseudotumor cerebri. Report of a familial occurrence. 38 8
4808492 1974
4
Vitamin A in the cerebrospinal fluid of patients with and without idiopathic intracranial hypertension. 8
12402264 2002
5
Familial benign intracranial hypertension. 8
932759 1976
6
Papilledema and idiopathic intracranial hypertension. 8
5775633 1969
7
Dural venous sinus stenting as a stand-alone treatment for spontaneous skull base CSF leak secondary to venous pseudotumor cerebri syndrome. 38
31352494 2019
8
Mechanical Thrombectomy and Thrombolysis for Dural Venous Sinus Thrombosis. 38
31226455 2019
9
Association between cycline antibiotic and development of pseudotumor cerebri syndrome. 38
30905802 2019
10
Quetiapine-Associated Pseudotumor Cerebri. 38
31356344 2019
11
Pseudotumor Cerebri Syndrome in Children. 38
31292773 2019
12
Cerebrospinal fluid dynamics in pediatric pseudotumor cerebri syndrome. 38
31325030 2019
13
Response to Correspondence "In Pseudotumor cerebri, hormonal contraception is not associated, and the diagnosis remains as 'Idiopathic Intracranial Hypertension'". 38
31130218 2019
14
Pseudotumor cerebri induced by topical application of steroid: a case report. 38
31274035 2019
15
A case of bilateral fourth nerve palsy associated with pseudotumor cerebri syndrome. 38
31038553 2019
16
In Pseudotumor Cerebri, Hormonal Contraception is Not Associated, and the Diagnosis Remains Idiopathic Intracranial Hypertension. 38
31014540 2019
17
Mastoid osteoma with stenosis of transverse and sigmoid sinuses as a cause of pseudotumor cerebri. 38
31262987 2019
18
Infantile Idiopathic Intracranial Hypertension: A Case Study and Review of the Literature. 38
31309848 2019
19
[A Case of Meningitis Caused by Globicatella sanguinis in a Patient with a Lumbo-peritoneal Shunt]. 38
31414636 2019
20
From epidemiology and neurometabolism to treatment: Vitamin D in pathogenesis of glioblastoma Multiforme (GBM) and a proposal for Vitamin D + all-trans retinoic acid + Temozolomide combination in treatment of GBM. 38
30937698 2019
21
Demographics, clinical features, and response to conventional treatments in pediatric Pseudotumor Cerebri syndrome: a single-center experience. 38
31025099 2019
22
The Occipital Emissary Vein: A Possible Marker for Pseudotumor Cerebri. 38
31072972 2019
23
Magnetic Resonance Imaging Findings in Pediatric Pseudotumor Cerebri Syndrome. 38
31303369 2019
24
The Significance and Reliability of Imaging Findings in Pseudotumor Cerebri. 38
31312231 2019
25
Epidural Blood Patch for Postdural Puncture Headache due to Lumboperitoneal Shunt Placement in a Patient With Pseudotumor Cerebri: A Case Report. 38
30272589 2019
26
Optic nerve sheath fenestration: a revised lateral approach for nerve access. 38
29565728 2019
27
Spinal CSF flow in response to forced thoracic and abdominal respiration. 38
30947716 2019
28
Idiopathic intracranial hypertension presenting with isolated unilateral facial nerve palsy: a case report. 38
30999940 2019
29
Nuances of Endovascular Treatment of Transverse/Sigmoid Sinus Stenosis With Stenting Venoplasty in a Patient With Pseudotumor Cerebri: 2-Dimensional Operative Video. 38
30060093 2019
30
Methotrexate-induced pseudotumor cerebri in a patient with juvenile idiopathic arthritis. 38
30083940 2019
31
RE: "An Estimation of the Risk of Pseudotumor Cerebri Among Users of the Levonorgestrel Intrauterine Device". 38
30723528 2019
32
Prognostic value of JAK2V617F mutation in pseudotumor cerebri associated with cerebral venous sinus thrombosis. 38
30251405 2019
33
Non-Syndromic Craniosynostosis Mimicking Primary Pseudotumor Cerebri Syndrome. 38
30474204 2019
34
Acute aseptic meningitis during isotretinoin treatment for nodular acne solely presenting with headache: case report and brief review of the literature. 38
30160569 2019
35
Do Most Patients With a Spontaneous Cerebrospinal Fluid Leak Have Idiopathic Intracranial Hypertension? 38
30747786 2019
36
Pattern of Idiopathic Intracranial Hypertension in Indian Population. 38
30692759 2019
37
Minocycline-induced transient depersonalization: A case report. 38
30719316 2019
38
Atypical Anti-MOG syndrome with aseptic meningoencephalitis and pseudotumor cerebri-like presentations. 38
30300850 2019
39
Previously Diagnosed Leber's Hereditary Optic Neuropathy with Clinical Signs of Idiopathic Intracranial Hypertension Responsive to Acetazolamide Therapy. 38
30820297 2019
40
Dural Arteriovenous Fistula Formation Complicated Cerebral Venous Sinus Stenosis After Venous Sinus Stenting. 38
30205216 2018
41
Pseudotumor cerebri and lung cancer-associated jugular vein thrombosis: Role of anatomical variations of torcular herophili. 38
30450429 2018
42
The role of lumboperitoneal shunts in managing chronic hydrocephalus with slit ventricles. 38
30239284 2018
43
Pseudotumor cerebri in childhood and adolescence: data from a specialized service. 38
30570018 2018
44
Headache Characteristics in Children With Pseudotumor Cerebri Syndrome, Elevated Opening Pressure Without Papilledema, and Normal Opening Pressure: A Retrospective Cohort Study. 38
30137653 2018
45
Pseudotumor Cerebri Syndrome is the Best Term for This Condition. 38
30501891 2018
46
Myelin oligodendrocyte glycoprotein-positive optic neuritis masquerading as pseudotumor cerebri at presentation. 38
29938337 2018
47
Pseudotumor cerebri syndrome (PCTS) - Losing sight in patients and doctors with regards to a growing epidemic. 38
29954644 2018
48
Magnetic resonance elastography to estimate brain stiffness: Measurement reproducibility and its estimate in pseudotumor cerebri patients. 38
29459315 2018
49
Pseudotumor cerebri in kaposiform lymphangiomatosis: a case report and pathogenetic hypothesis. 38
29654359 2018
50
Valsalva-triggered pseudotumor cerebri syndrome: Case series and pathogenetic implications. 38
30021914 2018

Variations for Intracranial Hypertension, Idiopathic

Expression for Intracranial Hypertension, Idiopathic

Search GEO for disease gene expression data for Intracranial Hypertension, Idiopathic.

Pathways for Intracranial Hypertension, Idiopathic

Pathways related to Intracranial Hypertension, Idiopathic according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.48 AQP4 AQP1

GO Terms for Intracranial Hypertension, Idiopathic

Biological processes related to Intracranial Hypertension, Idiopathic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 eye development GO:0001654 9.32 SH3PXD2B RBP4
2 renal water homeostasis GO:0003091 9.26 AQP4 AQP1
3 cell volume homeostasis GO:0006884 9.16 SLC12A3 AQP1
4 water transport GO:0006833 8.96 AQP4 AQP1
5 multicellular organismal water homeostasis GO:0050891 8.62 AQP4 AQP1

Molecular functions related to Intracranial Hypertension, Idiopathic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 channel activity GO:0015267 9.16 AQP4 AQP1
2 water channel activity GO:0015250 8.96 AQP4 AQP1
3 water transmembrane transporter activity GO:0005372 8.32 AQP1

Sources for Intracranial Hypertension, Idiopathic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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