MCID: INT003
MIFTS: 36

Intracranial Hypotension

Categories: Neuronal diseases

Aliases & Classifications for Intracranial Hypotension

MalaCards integrated aliases for Intracranial Hypotension:

Name: Intracranial Hypotension 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4723
MeSH 44 D019585
SNOMED-CT 67 433691000124104
ICD10 32 G96.81
UMLS 70 C0524812

Summaries for Intracranial Hypotension

Disease Ontology : 12 A brain disease that is characterized by low pressure inside the skull, and thus in the brain tissue and cerebrospinal fluid; may occur as a result of an occult or iatrogenically caused leak of CSF into another body cavity; may result in the downward displacement of the cerebellar tonsils through the foramen magnum or Chiari malformation; has symptom orthostatic headache; other symptoms are related to compression of cranial nerves due to brain sagging.

MalaCards based summary : Intracranial Hypotension is related to spontaneous intracranial hypotension and thrombosis. An important gene associated with Intracranial Hypotension is PTGDS (Prostaglandin D2 Synthase), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Hemostatics and Fibrin Tissue Adhesive have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and spinal cord.

Related Diseases for Intracranial Hypotension

Diseases related to Intracranial Hypotension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 321)
# Related Disease Score Top Affiliating Genes
1 spontaneous intracranial hypotension 32.9 TF PTGDS
2 thrombosis 31.0 SERPINC1 F3 F2
3 intracranial hypertension 30.7 SERPINC1 F3 F2
4 normal pressure hydrocephalus 30.5 TGFBR2 TF PTGDS
5 papilledema 30.2 SERPINC1 F3 F2
6 sagittal sinus thrombosis 30.2 SERPINC1 F3 F2
7 intracranial hypertension, idiopathic 30.1 PTGDS F2
8 thoracic outlet syndrome 30.0 SERPINC1 F2
9 abducens nerve disease 30.0 SERPINC1 SCYL3 F2
10 disseminated intravascular coagulation 29.8 SERPINC1 F3 F2
11 hellp syndrome 29.7 SERPINC1 F3 F2
12 patent foramen ovale 29.7 SERPINC1 F3 F2
13 headache 11.0
14 cerebrospinal fluid leak 10.8
15 ocular motor apraxia 10.7
16 hydrocephalus 10.4
17 marfan syndrome 10.4
18 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.4
19 pulsating exophthalmos 10.3 TGFBR2 PTGDS
20 frontotemporal dementia 10.3
21 ifap syndrome 2 10.3
22 siderosis 10.3
23 cranial nerve palsy 10.3
24 superficial siderosis 10.3
25 ataxia and polyneuropathy, adult-onset 10.3
26 encephalopathy 10.3
27 exostosis 10.3
28 thunderclap headache 10.3
29 achenbach syndrome 10.3 F3 F2
30 renal pelvis squamous cell carcinoma 10.3 F3 F2
31 synovial angioma 10.3 F3 F2
32 papillary adenofibroma 10.3 F3 F2
33 femoral neuropathy 10.3 F3 F2
34 emphysematous cholecystitis 10.3 F3 F2
35 hemopneumothorax 10.3 F3 F2
36 cerebral falx meningioma 10.3 F3 F2
37 ankylosing spondylitis 1 10.3 F3 F2
38 pulmonary embolism and infarction 10.3 F3 F2
39 acute pulmonary heart disease 10.3 F3 F2
40 epidural abscess 10.3 F3 F2
41 lemierre's syndrome 10.3 F3 F2
42 acute cor pulmonale 10.3 F3 F2
43 posterior cerebral artery infarction 10.3 F3 F2
44 gastric hemangioma 10.3 F3 F2
45 hemopericardium 10.2 F3 F2
46 qualitative platelet defect 10.2 F3 F2
47 mediastinitis 10.2 F3 F2
48 migraine with or without aura 1 10.2
49 cerebral sinovenous thrombosis 10.2 F3 F2
50 acquired von willebrand syndrome 10.2 F3 F2

Graphical network of the top 20 diseases related to Intracranial Hypotension:



Diseases related to Intracranial Hypotension

Symptoms & Phenotypes for Intracranial Hypotension

Drugs & Therapeutics for Intracranial Hypotension

Drugs for Intracranial Hypotension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hemostatics Phase 2
2 Fibrin Tissue Adhesive Phase 2
3 Coagulants Phase 2
4
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
5
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
6
Atorvastatin Approved 134523-00-5 60823
7 Gastrointestinal Agents
8 Anticholesteremic Agents
9 Hydroxymethylglutaryl-CoA Reductase Inhibitors
10 Antiemetics
11 Antimetabolites
12 Hormone Antagonists
13 glucocorticoids
14 Hormones
15 Antineoplastic Agents, Hormonal
16 Anti-Inflammatory Agents
17 Lipid Regulating Agents
18 Hypolipidemic Agents
19 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment of Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension. Completed NCT03276975 Phase 2 TISSEEL
2 Intraosseous Administration of Hypertonic Saline in Acute Brain-injured Patients: A Prospective Case Series and Literature Review Completed NCT03276494 Phase 2 Hypertonic saline
3 Non-invasive Estimation of CSF Pressure Using MRI in Patients With Spontaneous Intracranial Hypotension Completed NCT03041441
4 Clinical Effect and Cerebral Vasoconstriction Induced After Epidural Blood Patch Versus Epidural Hydroxyethyl Starch Patch in Patients With Headache Due to Intracranial Hypotension Completed NCT02570724 injection of HES " Voluven® "
5 Parallel Randomised Open Blind Evaluation Study of the Efficacy of 20° Trendelenburg Position During 24 Hours After Epidural Blood Patch in the Treatment of Spontaneous Intracranial Hypotension Recruiting NCT02261792
6 Effectiveness and Safety of Low Intracranial Pressure Treatment Strategies for Patients With Chronic Subdural Hematoma - A Randomized, Controlled, Multi-center Clinical Study Recruiting NCT04607447 Atorvastatin plus Dexamethasone
7 Postoperative Changes in Optic Nerve Sheath Diameter in Patients Undergoing Spinal Anesthesia for Cesarean Delivery Not yet recruiting NCT04301830
8 Spontaneous Spinal Cerebrospinal Fluid Leaks and Intracranial Hypotension Suspended NCT02603549

Search NIH Clinical Center for Intracranial Hypotension

Cochrane evidence based reviews: intracranial hypotension

Genetic Tests for Intracranial Hypotension

Anatomical Context for Intracranial Hypotension

MalaCards organs/tissues related to Intracranial Hypotension:

40
Brain, Pituitary, Spinal Cord, Eye, Bone, Kidney, Skin

Publications for Intracranial Hypotension

Articles related to Intracranial Hypotension:

(show top 50) (show all 1552)
# Title Authors PMID Year
1
Cerebrospinal Fluid Analysis. 61
33788511 2021
2
Spontaneous intracranial hypotension: features, diagnosis and management. 61
33686508 2021
3
Spinal subdural hygroma. 61
33393068 2021
4
[Spontaneous intracranial hypotension complicated by atlantoaxial subluxation: a case report]. 61
33627579 2021
5
Acephalgic Intracranial Hypotension: Subdural Hematoma Resolution After Blood Patch. 61
33750481 2021
6
Clinical Presentation, Investigation Findings, and Treatment Outcomes of Spontaneous Intracranial Hypotension Syndrome: A Systematic Review and Meta-analysis. 61
33393980 2021
7
Long-term telemetric intracerebral pressure monitoring as a tool in intracranial hypotension. 61
33389121 2021
8
Facial Nerve Paralysis Due to Spontaneous Intracranial Hypotension. 61
31547709 2021
9
Neuroimaging for Spontaneous Intracranial Hypotension Turned on Its Side. 61
33472920 2021
10
[Posture-dependent headache caused by spontaneous intracranial hypotension]. 61
33793124 2021
11
Spontaneous intracranial hypotension with brain sagging causing "prayer headache". 61
32736813 2021
12
Reversible parkinsonism and FTD due to spontaneous intracranial hypotension. 61
32981686 2021
13
Persistence and regredience of intraspinal fluid collection determine symptom control in intracranial hypotension syndrome. 61
32748098 2021
14
Clinical significance of Epstein-Barr virus in the cerebrospinal fluid of immunocompetent patients. 61
33493883 2021
15
Spontaneous intracranial hypotension and lumbosacral spondylolisthesis-case report of a rare association. 61
33493877 2021
16
CT-guided Fibrin Glue Occlusion of Cerebrospinal Fluid-Venous Fistulas. 61
33650903 2021
17
Cerebral venous sinus thrombosis following post-neurosurgical intracranial hypotension: A case report and systematic review of the literature. 61
33667532 2021
18
Diagnostic Yield of Lateral Decubitus Digital Subtraction Myelogram Stratified by Brain MRI Findings. 61
33472917 2021
19
[Bilateral Chronic Subdural Hematomas]. 61
33762443 2021
20
Cerebral venous thrombosis due to spontaneous intracranial hypotension: Reperfusion after epidural blood patch only. 61
33648781 2021
21
Diffuse Calvarial Hyperostosis in Patients with Spontaneous Intracranial Hypotension. 61
33220476 2021
22
Arachnoiditis, a complication of epidural blood patch for the treatment of low-pressure headache: A case report and systematic review. 61
33583044 2021
23
Delayed diagnosis of bilateral subdural effusions complicating intracranial hypotension in a patient presenting with post lumbar puncture headache. 61
33547096 2021
24
Evaluation and diagnosis of spontaneous intracranial hypotension with magnetic resonance imaging 61
33582651 2021
25
The importance of repeat digital subtraction myelography in the diagnosis of cryptogenic CSF-venous fistula causing spontaneous intracranial hypotension. 61
33525918 2021
26
A systematic review and meta-analysis of factors affecting the outcome of the epidural blood patching in spontaneous intracranial hypotension. 61
33611638 2021
27
Spinal Compliance Curves: Preliminary Experience with a New Tool for Evaluating Suspected CSF Venous Fistulas on CT Myelography in Patients with Spontaneous Intracranial Hypotension. 61
33602750 2021
28
Subarachnoid hemorrhage caused by spontaneous intracranial hypotension: two rare cases report. 61
33499724 2021
29
Predictors Associated with Outcomes of Epidural Blood Patch in Patients with Spontaneous Intracranial Hypotension. 61
33670838 2021
30
Letter to the editor regarding "Unilateral chronic subdural hematoma due to spontaneous intracranial hypotension: a report of four cases". 61
33538205 2021
31
Spontaneous spinal cerebrospinal fluid-venous fistulas in patients with orthostatic headaches and normal conventional brain and spine imaging. 61
33484155 2021
32
A Novel Endovascular Therapy for CSF Hypotension Secondary to CSF-Venous Fistulas. 61
33541895 2021
33
Brain volume changes in spontaneous intracranial hypotension: Revisiting the Monro-Kellie doctrine. 61
32847387 2021
34
Posterior reversible encephalopathy syndrome induced by intracranial hypotension in a postpartum patient. 61
32098543 2021
35
Fatal postoperative intracranial hypotension-associated venous congestion after elective laminectomy. 61
33748760 2021
36
Pneumocephalus: a radiological presentation of intracranial hypotension secondary to spinal anaesthesia. 61
33419756 2021
37
Bilateral Subdural Hygromas After Deep Brain Stimulation Implantation in the Setting of Unrecognized Intracranial Hypotension. 61
33680583 2021
38
Interpeduncular angle: A new parameter for assessing intracranial hypotension in fetuses with spinal dysraphism. 61
33480068 2021
39
The domino effect of acephalgic spontaneous intracranial hypotension. 61
32989589 2021
40
Pseudosubarachnoid hemorrhage: A systematic review of causes, diagnostic modalities, and outcomes in patients who present with pseudosubarachnoid hemorrhage. 61
33598345 2021
41
Spinal CSF-Venous Fistulas in Morbidly and Super Obese Patients with Spontaneous Intracranial Hypotension. 61
33334852 2021
42
CSF-Venous Fistula. 61
33475890 2021
43
Lumbosacral subdural hematoma associated with cranial subdural hematoma and craniocerebral surgery: Three cases and a systemic literature review. 61
33450270 2021
44
Decubitus CT Myelography for CSF-Venous Fistulas: A Procedural Approach. 61
33122215 2021
45
Cerebrospinal Fluid-Venous Fistulas: A Systematic Review and Examination of Individual Patient Data. 61
33438744 2021
46
Delayed recurrence of spontaneous intracranial hypotension syndrome mimicking a Chiari I malformation: Case report with a review of the literature. 61
33276003 2020
47
Unilateral chronic subdural hematoma due to spontaneous intracranial hypotension: a report of four cases. 61
31535558 2020
48
Clinical and radiological prognostic factors in spontaneous intracranial hypotension: a case series. 61
32845492 2020
49
Headache in spontaneous intracranial hypotension: an overview with indications for differential diagnosis in the clinical practice. 61
33034803 2020
50
Postdural puncture headache as a complication of lumbar puncture: clinical manifestations, pathophysiology, and treatment. 61
32997283 2020

Variations for Intracranial Hypotension

Expression for Intracranial Hypotension

Search GEO for disease gene expression data for Intracranial Hypotension.

Pathways for Intracranial Hypotension

Pathways related to Intracranial Hypotension according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.33 SERPINC1 F3 F2
2 10.96 SERPINC1 F3 F2
3 10.57 TGFBR2 SERPINC1

GO Terms for Intracranial Hypotension

Cellular components related to Intracranial Hypotension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.13 TF SERPINC1 F2
2 endoplasmic reticulum lumen GO:0005788 8.92 TF SERPINC1 FKBP14 F2

Biological processes related to Intracranial Hypotension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.43 SERPINC1 F3 F2
2 positive regulation of reactive oxygen species metabolic process GO:2000379 9.16 TGFBR2 F2
3 regulation of blood coagulation GO:0030193 8.96 SERPINC1 F2
4 hemostasis GO:0007599 8.8 SERPINC1 F3 F2

Sources for Intracranial Hypotension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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