MCID: INT003
MIFTS: 34

Intracranial Hypotension

Categories: Neuronal diseases

Aliases & Classifications for Intracranial Hypotension

MalaCards integrated aliases for Intracranial Hypotension:

Name: Intracranial Hypotension 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4723
MeSH 44 D019585
SNOMED-CT 68 433691000124104
UMLS 73 C0524812

Summaries for Intracranial Hypotension

MalaCards based summary : Intracranial Hypotension is related to spontaneous intracranial hypotension and headache. An important gene associated with Intracranial Hypotension is TGFBR2 (Transforming Growth Factor Beta Receptor 2). The drugs Nicotinamide and Niacin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and pituitary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 A spontaneous cerebrospinal fluid leak (SCSFL) is a medical condition in which the cerebrospinal fluid... more...

Related Diseases for Intracranial Hypotension

Diseases related to Intracranial Hypotension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 spontaneous intracranial hypotension 12.3
2 headache 10.6
3 cerebrospinal fluid leak 10.4
4 thrombosis 10.4
5 cerebritis 10.4
6 cervicitis 10.3
7 thrombophilia due to thrombin defect 10.2
8 intracranial hypertension 10.1
9 marfan syndrome 10.0
10 aneurysm 10.0
11 frontotemporal dementia 10.0
12 dementia 10.0
13 cranial nerve palsy 10.0
14 meningitis 10.0
15 frontotemporal dementia with parkinsonism-17 10.0
16 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
17 siderosis 10.0
18 neuropathy 10.0
19 superficial siderosis 10.0
20 abducens palsy 9.9
21 stroke, ischemic 9.9
22 hydrocephalus 9.9
23 patulous eustachian tube 9.9
24 optic nerve disease 9.9
25 tarlov cysts 9.9
26 thunderclap headache 9.9
27 encephalopathy 9.9
28 tremor 9.9
29 neurofibromatosis, type i 9.8
30 neurofibromatosis, type iv, of riccardi 9.8
31 meningocele 9.8
32 intracranial aneurysm 9.8
33 arachnoiditis 9.8
34 syringomyelia 9.8
35 radiculopathy 9.8
36 movement disease 9.8
37 lynch syndrome 9.7 OGG1 TGFBR2
38 breast cancer 9.7
39 multiple sclerosis 9.7
40 systemic lupus erythematosus 9.7
41 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1 9.7
42 scleroderma, familial progressive 9.7
43 spinal arachnoiditis 9.7
44 strabismus 9.7
45 trigeminal neuralgia 9.7
46 hydrocephalus, normal-pressure 9.7
47 aging 9.7
48 anorexia nervosa 9.7
49 wegener granulomatosis 9.7
50 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 2 9.7

Graphical network of the top 20 diseases related to Intracranial Hypotension:



Diseases related to Intracranial Hypotension

Symptoms & Phenotypes for Intracranial Hypotension

GenomeRNAi Phenotypes related to Intracranial Hypotension according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.68 TGFBR2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.68 OGG1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.68 TGFBR2 OGG1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.68 TGFBR2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.68 TGFBR2 OGG1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.68 TGFBR2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.68 TGFBR2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.68 TGFBR2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.68 TGFBR2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.68 TGFBR2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.68 TGFBR2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.68 TGFBR2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.68 OGG1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.68 OGG1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.68 OGG1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.68 OGG1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.68 TGFBR2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.68 TGFBR2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.68 TGFBR2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.68 TGFBR2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.68 TGFBR2

Drugs & Therapeutics for Intracranial Hypotension

Drugs for Intracranial Hypotension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotinamide Approved, Investigational, Nutraceutical Phase 2 98-92-0 936
2
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
4 Micronutrients Phase 2
5 Nicotinic Acids Phase 2
6 Trace Elements Phase 2
7 Vitamin B Complex Phase 2
8 Vitamins Phase 2
9 Fibrin Tissue Adhesive Phase 2
10 Coagulants Phase 2
11 Hemostatics Phase 2
12 Folate Nutraceutical Phase 2
13 Vitamin B3 Nutraceutical Phase 2
14 Vitamin B9 Nutraceutical Phase 2
15 Hydroxyethyl Starch Derivatives Not Applicable
16 Plasma Substitutes Not Applicable
17 Blood Substitutes Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 IRB-HSR# 14299: The Use of the Intrathoracic Pressure Regulator (ITPR) to Improve Cerebral Perfusion Pressure in Patients With Altered Intracranial Elastance Unknown status NCT01205607 Phase 2
2 A Pilot Study: Safety & TOlerability of Hypertonic Saline Administration Via IntraOsseous Access Completed NCT03276494 Phase 2 injection of intraosseous hypertonic saline
3 Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension. Completed NCT02017444 Phase 2 AZD4017
4 A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment Recruiting NCT03276975 Phase 2 TISSEEL
5 Spontaneous Intracranial Hypotension Treatment "SIHT" Recruiting NCT02261792 Not Applicable
6 Non-invasive Estimation of CSF Pressure Using MRI in Patients With Spontaneous Intracranial Hypotension Recruiting NCT03041441 Not Applicable
7 HES Patch Versus Blood Patch Recruiting NCT02570724 Not Applicable injection of HES " Voluven® "
8 Pituitary Function and Spontaneous Intracranial Hypotension Active, not recruiting NCT02603549

Search NIH Clinical Center for Intracranial Hypotension

Cochrane evidence based reviews: intracranial hypotension

Genetic Tests for Intracranial Hypotension

Anatomical Context for Intracranial Hypotension

MalaCards organs/tissues related to Intracranial Hypotension:

41
Brain, Spinal Cord, Pituitary, Eye, Testes, Kidney, Liver

Publications for Intracranial Hypotension

Articles related to Intracranial Hypotension:

(show top 50) (show all 675)
# Title Authors Year
1
Spontaneous intracranial hypotension complicated by cerebral venous thrombosis. ( 29955241 )
2018
2
Chest Pain as a Manifestation of Intracranial Hypotension: Report of Four Cases. ( 29793814 )
2018
3
Intracranial hypotension mimicking chronic progressive external ophthalmoplegia. ( 29300676 )
2018
4
Isolated gait dysfunction due to intracranial hypotension. ( 29980638 )
2018
5
Association of hemolysis, elevated liver enzymes, low platelets syndrome with posterior reversible encephalopathy and intracranial hypotension. ( 29322989 )
2018
6
Prevalence of hyperdense paraspinal vein sign in patients with spontaneous intracranial hypotension without dural CSF leak on standard CT myelography. ( 29217497 )
2018
7
Spontaneous intracranial hypotension with chronic brain sagging causing foramen magnum CSF circulation disorder reversible after lumbar epidural blood patch. ( 29441482 )
2018
8
New-onset headaches secondary to spontaneous intracranial hypotension. ( 29866680 )
2018
9
Distribution Patterns of Spinal Epidural Fluid in Patients with Spontaneous Intracranial Hypotension Syndrome. ( 29710056 )
2018
10
Acquired Chiari I Malformation Secondary to Spontaneous Intracranial Hypotension Syndrome and Persistent Hypoglycemia: A Case Report. ( 29513222 )
2018
11
Spontaneous Intracranial Hypotension as a Cause of Exacerbation in Huntington's Disease. ( 29756587 )
2018
12
Low tension of the dural sac as a cause of unsuccessful myelography in spontaneous intracranial hypotension: Evidence from computed tomographic-guided myelography. ( 29547178 )
2018
13
Effect of epidural blood injection on upright posture intolerance in patients with headaches due to intracranial hypotension: A prospective study. ( 29920982 )
2018
14
Targeted Epidural Blood Patch Treatment for Refractory Spontaneous Intracranial Hypotension in China. ( 29765818 )
2018
15
Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid. ( 29621631 )
2018
16
Spontaneous Intracranial Hypotension Induced Headaches and Onabotulinum Toxin A: A Case Report. ( 29103382 )
2018
17
Iatrogenic Development of Cerebrospinal Fluid Leakage in Diagnosing Spontaneous Intracranial Hypotension. ( 29629045 )
2018
18
Spontaneous occult intracranial hypotension precipitating life-threatening cerebral venous thrombosis: case report. ( 29600909 )
2018
19
Intracranial Hypotension and Hypertension Associated With Reconstructive Cranioplasty After Decompressive Craniectomy: Report of a Lethal Complication With Recommended Strategies for Future Avoidance. ( 29927824 )
2018
20
Behavioral Variant Frontotemporal Dementia as a Serious Complication of Spontaneous Intracranial Hypotension. ( 29534203 )
2018
21
Spontaneous Intracranial Hypotension: 10 Myths and Misperceptions. ( 29797515 )
2018
22
Ossified ligamentum flavum of the thoracic spine presenting as spontaneous intracranial hypotension: case report. ( 29372863 )
2018
23
"Sinking into a coma" from spontaneous intracranial hypotension. ( 29653984 )
2018
24
Coma: A serious complication of spontaneous intracranial hypotension. ( 29653986 )
2018
25
Noninvasive assessment of intracranial elastance and pressure in spontaneous intracranial hypotension by MRI. ( 29437266 )
2018
26
An Objective Study of Anatomic Shifts in Intracranial Hypotension Using Four Anatomic Planes. ( 29713529 )
2018
27
Spontaneous Intracranial Hypotension Presenting as a "Pseudo-Chiari 1. ( 28357166 )
2017
28
Surgical "Fat Patch" Improves Secondary Intracranial Hypotension Orthostatic Headache Associated with Lumbosacral Dural Ectasia. ( 28866058 )
2017
29
Multilevel, ultra-large-volume epidural blood patch for the treatment of neurocognitive decline associated with spontaneous intracranial hypotension: case report. ( 28984516 )
2017
30
Targeted epidural blood patch under O-arm-guided stereotactic navigation in patients with intracranial hypotension associated with a spinal CSF leak and ventral dural defect. ( 28790007 )
2017
31
Factors predicting response to the first epidural blood patch in spontaneous intracranial hypotension. ( 28043956 )
2017
32
Association of Cerebral Venous Thrombosis and Intracranial Hypotension: Review of 3 Cases. ( 28623115 )
2017
33
Magnetic Resonance Imaging of Intracranial Hypotension: Diagnostic Value of Combined Qualitative Signs and Quantitative Metrics. ( 28708719 )
2017
34
Ventral longitudinal intraspinal fluid collection: Rare presentation as brachial amyotrophy and intracranial hypotension. ( 28402198 )
2017
35
Spontaneous Intracranial Hypotension: A Review and Introduction of an Algorithm For Management. ( 28192268 )
2017
36
Diagnostic Imaging and Clinical Features of Intracranial Hypotension - Review of Literature. ( 29657653 )
2017
37
Spinal meningeal diverticula, spontaneous intracranial hypotension, and superficial siderosis. ( 28130464 )
2017
38
Intracranial Hypotension-associated Cerebral Swelling following Cranioplasty: Report of Two Cases. ( 29114315 )
2017
39
Intracranial structural alteration predicts treatment outcome in patients with spontaneous intracranial hypotension. ( 28110544 )
2017
40
Novel orbital findings of intracranial hypotension. ( 27840264 )
2017
41
Quantitative Measurement of CSF in Patients with Spontaneous Intracranial Hypotension. ( 28385881 )
2017
42
Intracranial Hypotension Following Traumatic Brain Injury: A Diagnostic and Therapeutic Challenge. ( 28624560 )
2017
43
Hypoactive-hypoalert behaviour and thalamic hypometabolism due to intracranial hypotension. ( 28433974 )
2017
44
Spontaneous Intracranial Hypotension With Site of Leak Detected Only After 111In-DTPA Cisternogram. ( 28079571 )
2017
45
Reversible cerebral vasoconstriction syndrome and posterior reversible encephalopathy syndrome associated with intracranial hypotension. ( 27848124 )
2017
46
Intracranial hypotension causing pituitary enlargement. ( 28500117 )
2017
47
Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure? ( 28679427 )
2017
48
Abnormal BAEP and internal auditory canal MRI in intracranial hypotension. ( 28819061 )
2017
49
Reversible Holmes' tremor due to spontaneous intracranial hypotension. ( 28754752 )
2017
50
Spontaneous intracranial hypotension diagnosed as Chiari I malformation. ( 28348118 )
2017

Variations for Intracranial Hypotension

Expression for Intracranial Hypotension

Search GEO for disease gene expression data for Intracranial Hypotension.

Pathways for Intracranial Hypotension

GO Terms for Intracranial Hypotension

Biological processes related to Intracranial Hypotension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.32 TGFBR2 TWIST1
2 roof of mouth development GO:0060021 9.26 TGFBR2 TWIST1
3 positive regulation of epithelial to mesenchymal transition GO:0010718 9.16 TGFBR2 TWIST1
4 embryonic cranial skeleton morphogenesis GO:0048701 8.96 TGFBR2 TWIST1
5 aging GO:0007568 8.8 GJB6 OGG1 TGFBR2

Sources for Intracranial Hypotension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....