MCID: INT003
MIFTS: 34

Intracranial Hypotension

Categories: Neuronal diseases

Aliases & Classifications for Intracranial Hypotension

MalaCards integrated aliases for Intracranial Hypotension:

Name: Intracranial Hypotension 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4723
MeSH 44 D019585
UMLS 73 C0524812

Summaries for Intracranial Hypotension

Disease Ontology : 12 A brain disease that is characterized by low pressure inside the skull, and thus in the brain tissue and cerebrospinal fluid; may occur as a result of an occult or iatrogenically caused leak of CSF into another body cavity; may result in the downward displacement of the cerebellar tonsils through the foramen magnum or Chiari malformation; has symptom orthostatic headache; other symptoms are related to compression of cranial nerves due to brain sagging.

MalaCards based summary : Intracranial Hypotension is related to spontaneous intracranial hypotension and hydrocephalus, normal-pressure, and has symptoms including orthostatic headache; other symptoms are related to compression of cranial nerves due to brain sagging An important gene associated with Intracranial Hypotension is PTGDS (Prostaglandin D2 Synthase). The drugs Nicotinamide and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and tonsil, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 A spontaneous cerebrospinal fluid leak (SCSFL) is a medical condition in which the cerebrospinal fluid... more...

Related Diseases for Intracranial Hypotension

Diseases related to Intracranial Hypotension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 spontaneous intracranial hypotension 33.8 PTGDS TF
2 hydrocephalus, normal-pressure 29.4 OGG1 PTGDS
3 headache 10.7
4 thrombosis 10.5
5 cerebrospinal fluid leak 10.4
6 thrombophilia due to thrombin defect 10.4
7 intracranial hypertension 10.3
8 marfan syndrome 10.2
9 frontotemporal dementia 10.2
10 dementia 10.2
11 frontotemporal dementia with parkinsonism-17 10.2
12 siderosis 10.1
13 encephalopathy 10.1
14 superficial siderosis 10.1
15 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
16 cranial nerve palsy 10.1
17 orbital cyst 10.0 PTGDS TF
18 abducens palsy 10.0
19 ocular motor apraxia 10.0
20 stroke, ischemic 10.0
21 hydrocephalus 10.0
22 patulous eustachian tube 10.0
23 optic nerve disease 10.0
24 syringomyelia 10.0
25 neuropathy 10.0
26 thunderclap headache 10.0
27 tremor 10.0
28 congenital disorder of glycosylation, type in 9.9 PTGDS TF
29 neurofibromatosis, type i 9.9
30 meningocele 9.9
31 exostosis 9.9
32 sagittal sinus thrombosis 9.9
33 movement disease 9.9
34 chiari malformation 9.9
35 communicating hydrocephalus 9.9 OGG1 PTGDS
36 aortic valve disease 1 9.8
37 cystic angiomatosis of bone, diffuse 9.8
38 multiple sclerosis 9.8
39 systemic lupus erythematosus 9.8
40 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1 9.8
41 scleroderma, familial progressive 9.8
42 strabismus 9.8
43 temporal arteritis 9.8
44 trigeminal neuralgia 9.8
45 vertigo, benign recurrent 9.8
46 chiari malformation type ii 9.8
47 anorexia nervosa 9.8
48 granulomatosis with polyangiitis 9.8
49 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 2 9.8
50 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 3 9.8

Graphical network of the top 20 diseases related to Intracranial Hypotension:



Diseases related to Intracranial Hypotension

Symptoms & Phenotypes for Intracranial Hypotension

Symptoms:

12
  • orthostatic headache; other symptoms are related to compression of cranial nerves due to brain sagging

GenomeRNAi Phenotypes related to Intracranial Hypotension according to GeneCards Suite gene sharing:

26 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.99 PTGDS
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.99 TGFBR2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.99 OGG1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.99 TGFBR2 OGG1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.99 TGFBR2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.99 TGFBR2 OGG1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.99 TGFBR2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.99 TGFBR2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.99 TGFBR2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.99 TGFBR2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.99 TGFBR2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.99 PTGDS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.99 PTGDS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.99 PTGDS TGFBR2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.99 TGFBR2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.99 OGG1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.99 OGG1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.99 OGG1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.99 OGG1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.99 TGFBR2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.99 PTGDS
22 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.99 TGFBR2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.99 PTGDS
24 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.99 TGFBR2
25 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.99 TGFBR2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.99 TGFBR2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.99 PTGDS
28 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.99 PTGDS

Drugs & Therapeutics for Intracranial Hypotension

Drugs for Intracranial Hypotension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotinamide Approved, Investigational Phase 2 98-92-0 936
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
3
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
4 Vitamin B9 Phase 2
5 Vitamins Phase 2
6 Vitamin B3 Phase 2
7 Trace Elements Phase 2
8 Micronutrients Phase 2
9 Nicotinic Acids Phase 2
10 Folate Phase 2
11 Vitamin B Complex Phase 2
12 Hemostatics Phase 2
13 Coagulants Phase 2
14 Fibrin Tissue Adhesive Phase 2
15 Plasma Substitutes Not Applicable
16 Hydroxyethyl Starch Derivatives Not Applicable
17 Blood Substitutes Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 IRB-HSR# 14299: The Use of the Intrathoracic Pressure Regulator (ITPR) to Improve Cerebral Perfusion Pressure in Patients With Altered Intracranial Elastance Unknown status NCT01205607 Phase 2
2 A Pilot Study: Safety & TOlerability of Hypertonic Saline Administration Via IntraOsseous Access Completed NCT03276494 Phase 2 injection of intraosseous hypertonic saline
3 Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension. Completed NCT02017444 Phase 2 AZD4017
4 A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment Recruiting NCT03276975 Phase 2 TISSEEL
5 Spontaneous Intracranial Hypotension Treatment "SIHT" Unknown status NCT02261792 Not Applicable
6 HES Patch Versus Blood Patch Completed NCT02570724 Not Applicable injection of HES " Voluven® "
7 Non-invasive Estimation of CSF Pressure Using MRI in Patients With Spontaneous Intracranial Hypotension Recruiting NCT03041441 Not Applicable
8 Pituitary Function and Spontaneous Intracranial Hypotension Active, not recruiting NCT02603549

Search NIH Clinical Center for Intracranial Hypotension

Cochrane evidence based reviews: intracranial hypotension

Genetic Tests for Intracranial Hypotension

Anatomical Context for Intracranial Hypotension

MalaCards organs/tissues related to Intracranial Hypotension:

41
Brain, Spinal Cord, Tonsil, Pituitary, Eye, Kidney, Bone

Publications for Intracranial Hypotension

Articles related to Intracranial Hypotension:

(show top 50) (show all 828)
# Title Authors Year
1
Spontaneous intracranial hypotension complicated by cerebral venous thrombosis. ( 29955241 )
2018
2
Chest Pain as a Manifestation of Intracranial Hypotension: Report of Four Cases. ( 29793814 )
2018
3
Intracranial hypotension mimicking chronic progressive external ophthalmoplegia. ( 29300676 )
2018
4
Isolated gait dysfunction due to intracranial hypotension. ( 29980638 )
2018
5
Association of hemolysis, elevated liver enzymes, low platelets syndrome with posterior reversible encephalopathy and intracranial hypotension. ( 29322989 )
2018
6
Prevalence of hyperdense paraspinal vein sign in patients with spontaneous intracranial hypotension without dural CSF leak on standard CT myelography. ( 29217497 )
2018
7
Spontaneous intracranial hypotension with chronic brain sagging causing foramen magnum CSF circulation disorder reversible after lumbar epidural blood patch. ( 29441482 )
2018
8
New-onset headaches secondary to spontaneous intracranial hypotension. ( 29866680 )
2018
9
Distribution Patterns of Spinal Epidural Fluid in Patients with Spontaneous Intracranial Hypotension Syndrome. ( 29710056 )
2018
10
Acquired Chiari I Malformation Secondary to Spontaneous Intracranial Hypotension Syndrome and Persistent Hypoglycemia: A Case Report. ( 29513222 )
2018
11
Spontaneous Intracranial Hypotension as a Cause of Exacerbation in Huntington's Disease. ( 29756587 )
2018
12
Low tension of the dural sac as a cause of unsuccessful myelography in spontaneous intracranial hypotension: Evidence from computed tomographic-guided myelography. ( 29547178 )
2018
13
Effect of epidural blood injection on upright posture intolerance in patients with headaches due to intracranial hypotension: A prospective study. ( 29920982 )
2018
14
Targeted Epidural Blood Patch Treatment for Refractory Spontaneous Intracranial Hypotension in China. ( 29765818 )
2018
15
Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid. ( 29621631 )
2018
16
Spontaneous Intracranial Hypotension Induced Headaches and Onabotulinum Toxin A: A Case Report. ( 29103382 )
2018
17
Iatrogenic Development of Cerebrospinal Fluid Leakage in Diagnosing Spontaneous Intracranial Hypotension. ( 29629045 )
2018
18
Spontaneous occult intracranial hypotension precipitating life-threatening cerebral venous thrombosis: case report. ( 29600909 )
2018
19
Intracranial Hypotension and Hypertension Associated With Reconstructive Cranioplasty After Decompressive Craniectomy: Report of a Lethal Complication With Recommended Strategies for Future Avoidance. ( 29927824 )
2018
20
Behavioral Variant Frontotemporal Dementia as a Serious Complication of Spontaneous Intracranial Hypotension. ( 29534203 )
2018
21
Spontaneous Intracranial Hypotension: 10 Myths and Misperceptions. ( 29797515 )
2018
22
Ossified ligamentum flavum of the thoracic spine presenting as spontaneous intracranial hypotension: case report. ( 29372863 )
2018
23
"Sinking into a coma" from spontaneous intracranial hypotension. ( 29653984 )
2018
24
Coma: A serious complication of spontaneous intracranial hypotension. ( 29653986 )
2018
25
Noninvasive assessment of intracranial elastance and pressure in spontaneous intracranial hypotension by MRI. ( 29437266 )
2018
26
Disturbed Consciousness and Coma: Diagnosis and Management of Intracranial Hypotension Caused by a Spinal Cerebrospinal Fluid Leak. ( 30292664 )
2018
27
Intracranial hypotension and hypertension: reversible Chiari malformation due to dynamic cerebrospinal fluid abnormalities in Gorham-Stout disease. Case report. ( 30074451 )
2018
28
Spontaneous Intracranial Hypotension Presenting With Frontotemporal Dementia: A Case Report. ( 30174645 )
2018
29
Epidural blood patch treatment of diplopia that developed after headache resolution in a patient with spontaneous intracranial hypotension. ( 30186972 )
2018
30
Cervical disc herniation as a rare cause of intracranial hypotension: a case report. ( 29502270 )
2018
31
An Objective Study of Anatomic Shifts in Intracranial Hypotension Using Four Anatomic Planes. ( 29713529 )
2018
32
Benign paroxysmal positional vertigo in spontaneous intracranial hypotension. ( 30052143 )
2018
33
Management of Presumed Spontaneous Intracranial Hypotension: A Case Report. ( 30052533 )
2018
34
Posterior Approach and Spinal Cord Release for 360° Repair of Dural Defects in Spontaneous Intracranial Hypotension. ( 30053151 )
2018
35
Intracranial Hypotension with Coma: Microsurgical Repair of a Spinal Ventral Dural Tear and Drainage of Subdural Hematoma with Intracranial Pressure Monitoring. ( 30055363 )
2018
36
Percutaneous Epidural Hydrogel Sealant for the Treatment of Spontaneous Intracranial Hypotension: A Case Report of Chronic Thoracic Neuralgia and Technical Lessons Learned. ( 30057825 )
2018
37
Spontaneous intracranial hypotension due to sacral diverticula: Two-case history and a pocket-sized review. ( 30072229 )
2018
38
Sonography of the optic nerve sheath diameter before and after microsurgical closure of a dural CSF fistula in patients with spontaneous intracranial hypotension - a consecutive cohort study. ( 30099952 )
2018
39
Challenges in the Diagnosis and Treatment of Spontaneous Intracranial Hypotension. ( 30226451 )
2018
40
Cryptogenic Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension: Role of Dynamic CT Myelography. ( 30226459 )
2018
41
Spontaneous intracranial hypotension and its complications. ( 30231122 )
2018
42
Cerebral Venous Thrombosis in Spontaneous Intracranial Hypotension: A Report on 4 Cases and a Review of the Literature. ( 30238694 )
2018
43
Clinical effect of the proximity of epidural blood patch injection to the leakage site in spontaneous intracranial hypotension. ( 30282491 )
2018
44
Study of lamina cribrosa depth and optic nerve in patients with spontaneous intracranial hypotension. ( 30295059 )
2018
45
Correlations among brain and spinal MRI findings in spontaneous intracranial hypotension. ( 30301380 )
2018
46
Vocal fold paralysis due to intracranial hypotension following spinal anesthesia. ( 30315318 )
2018
47
Superior sagittal sinus thrombosis as a rare complication of spontaneous intracranial hypotension syndrome: a case report and review of the literature. ( 30345841 )
2018
48
A Case of Intracranial Hypotension after Horse Riding. ( 30375764 )
2018
49
Secondary Endolymphatic Hydrops Associated With Spontaneous Intracranial Hypotension. ( 30476972 )
2018
50
Letter to the Editor. Epidural blood patch in superficial siderosis caused by spontaneous intracranial hypotension. ( 30485219 )
2018

Variations for Intracranial Hypotension

Expression for Intracranial Hypotension

Search GEO for disease gene expression data for Intracranial Hypotension.

Pathways for Intracranial Hypotension

GO Terms for Intracranial Hypotension

Biological processes related to Intracranial Hypotension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 8.8 GJB6 OGG1 TGFBR2

Sources for Intracranial Hypotension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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