MCID: INT395
MIFTS: 39

Intracranial Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Intracranial Meningioma

MalaCards integrated aliases for Intracranial Meningioma:

Name: Intracranial Meningioma 12 54

Classifications:



External Ids:

Disease Ontology 12 DOID:0080842
NCIt 50 C4656
SNOMED-CT 67 302820008
UMLS 71 C0349604

Summaries for Intracranial Meningioma

Disease Ontology : 12 A meningioma that arises within the cranial cavity.

MalaCards based summary : Intracranial Meningioma is related to meningioma, familial and benign meningioma. An important gene associated with Intracranial Meningioma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Everolimus and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and pituitary, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and endocrine/exocrine gland

Related Diseases for Intracranial Meningioma

Diseases related to Intracranial Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 319)
# Related Disease Score Top Affiliating Genes
1 meningioma, familial 30.6 PGR PCNA MKI67 IGF2 ESR1 CDKN2A
2 benign meningioma 29.8 PGR PCNA MKI67
3 anaplastic astrocytoma 29.8 MLH1 MGMT CDKN2A
4 adenoma 29.4 MSH2 MLH1 MKI67 MGMT CDKN2A
5 bilateral breast cancer 29.3 PGR MLH1 ESR1 CDKN2A
6 prostatic hypertrophy 29.2 PGR PCNA ESR1
7 brain meningioma 11.4
8 spinal meningioma 11.1
9 secretory meningioma 11.1
10 lymphoplasmacyte-rich meningioma 11.1
11 hyperostosis 10.3
12 brain edema 10.3
13 atypical polypoid adenomyoma 10.3 MLH1 CDKN2A
14 meningothelial meningioma 10.2
15 gliofibroma 10.2 MGMT CDKN2A
16 endometrial squamous cell carcinoma 10.2 PGR CDKN2A
17 atrophic vulva 10.2 ESR1 CDKN2A
18 endometrial mucinous adenocarcinoma 10.2 PGR CDKN2A
19 transitional meningioma 10.2
20 neurofibromatosis 10.2
21 supratentorial cancer 10.2 MGMT CDKN2A
22 extrahepatic bile duct adenoma 10.2 MSH2 MLH1
23 renal pelvis transitional cell carcinoma 10.2 MSH2 MLH1
24 adenosquamous colon carcinoma 10.2 MSH2 MLH1
25 rectum signet ring adenocarcinoma 10.2 MSH2 MLH1
26 breast papillomatosis 10.2 PGR CDKN2A
27 autosomal dominant non-syndromic intellectual disability 8 10.2 MSH2 MLH1
28 appendix carcinoid tumor 10.2 MSH2 MLH1
29 mismatch repair cancer syndrome 10.2 MSH2 MLH1
30 jejunal cancer 10.2 MSH2 MLH1
31 malignant spiradenoma 10.2 PGR CDKN2A
32 ascending colon cancer 10.2 MSH2 MLH1
33 lower lip cancer 10.2 MSH2 MLH1
34 headache 10.2
35 colorectal cancer, hereditary nonpolyposis, type 6 10.2 MSH2 MLH1
36 colorectal cancer, hereditary nonpolyposis, type 5 10.2 MSH2 MLH1
37 spitz nevus 10.2 MKI67 CDKN2A
38 ameloblastic carcinoma 10.2 MKI67 CDKN2A
39 sebaceous gland neoplasm 10.2 MSH2 MLH1
40 vulvar disease 10.1 PGR CDKN2A
41 vulvar dystrophy 10.1 PGR CDKN2A
42 small intestine adenocarcinoma 10.1 MSH2 MLH1
43 duodenum adenocarcinoma 10.1 MSH2 MLH1
44 anal fistula 10.1 MSH2 MLH1
45 melanocytic nevus syndrome, congenital 10.1 MSH2 MLH1
46 supratentorial meningioma 10.1
47 fibrous meningioma 10.1
48 glassy cell carcinoma of the cervix 10.1 PGR ESR1
49 breast intraductal papillomatosis 10.1 PGR ESR1
50 intraductal papilloma 10.1 PGR ESR1

Graphical network of the top 20 diseases related to Intracranial Meningioma:



Diseases related to Intracranial Meningioma

Symptoms & Phenotypes for Intracranial Meningioma

GenomeRNAi Phenotypes related to Intracranial Meningioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.02 ESR1 IGF2 MKI67 MSH2 PCNA

MGI Mouse Phenotypes related to Intracranial Meningioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.03 CDKN2A DVL3 ESR1 IGF2 MGMT MLH1
2 hematopoietic system MP:0005397 10.01 CDKN2A DVL3 ESR1 IGF2 MLH1 MSH2
3 immune system MP:0005387 9.97 CDKN2A DVL3 ESR1 IGF2 MLH1 MSH2
4 mortality/aging MP:0010768 9.91 CDKN2A DVL3 ESR1 IGF2 MGMT MLH1
5 integument MP:0010771 9.87 CDKN2A ESR1 GSTP1 IGF2 MLH1 MSH2
6 neoplasm MP:0002006 9.7 CDKN2A ESR1 GSTP1 MGMT MLH1 MSH2
7 no phenotypic analysis MP:0003012 9.5 CDKN2A ESR1 IGF2 MGMT MKI67 PCNA
8 respiratory system MP:0005388 9.1 CDKN2A DVL3 ESR1 IGF2 MGMT MLH1

Drugs & Therapeutics for Intracranial Meningioma

Drugs for Intracranial Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3 Angiogenesis Inhibitors Phase 2
4 Antineoplastic Agents, Immunological Phase 2
5 Immunosuppressive Agents Phase 2
6 Immunologic Factors Phase 2
7
Ropivacaine Approved 84057-95-4 71273 175805
8 Anesthetics
9 Anesthetics, Local

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Observation Versus Conventional-Fractionated Radiotherapy or Radiosurgery After Non-radical Surgery for Benign Intracranial Meningiomas: A Phase III Study Terminated NCT00104936 Phase 3
2 Phase II Trial of SMO/AKT/NF2 Inhibitors in Progressive Meningiomas With SMO/AKT/NF2 Mutations Suspended NCT02523014 Phase 2 vismodegib;GSK2256098
3 A Phase II Trial of the Combination of Bevacizumab and Everolimus in Patients With Refractory, Progressive Intracranial Meningioma Terminated NCT00972335 Phase 2 Everolimus;Bevacizumab
4 Hyperbaric Oxygen Therapy Can Improve Neurological State Post Meningioma Removal Surgery -Randomized Prospective Trial Unknown status NCT02084927 Phase 1
5 Effects of Preoperative Scalp Nerve Block on Postoperative Recovery Quality in Patients Undergoing Excision of Intracranial Meningioma Completed NCT03648034
6 Multisession Radiosurgery in Large Meningiomas Active, not recruiting NCT02974127

Search NIH Clinical Center for Intracranial Meningioma

Genetic Tests for Intracranial Meningioma

Anatomical Context for Intracranial Meningioma

MalaCards organs/tissues related to Intracranial Meningioma:

40
Brain, Breast, Pituitary, Spinal Cord, Endothelial, Colon, Pancreas

Publications for Intracranial Meningioma

Articles related to Intracranial Meningioma:

(show top 50) (show all 845)
# Title Authors PMID Year
1
Ki-67 and vascular endothelial growth factor expression in intracranial meningiomas in dogs. 61 54
19175733 2009
2
Significance of proliferating cell nuclear antigen in predicting recurrence of intracranial meningioma. 54 61
8613841 1996
3
Growth rate of intracranial meningioma: tumor doubling time and proliferating cell nuclear antigen staining index. 54 61
7623949 1995
4
Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study. 61
33536184 2021
5
Subcutaneous seeding following surgical excision of an intracranial meningioma in a cat. 61
33588467 2021
6
Nation-wide Brain Tumor Registry-based Study of Intracranial Meningioma in Japan: Analysis of Surgery-related Risks. 61
33361655 2021
7
Meningiomas and cyproterone acetate: a retrospective, monocentric cohort of 388 patients treated by surgery or radiotherapy for intracranial meningioma. 61
33392938 2021
8
Neurosurgery for intracranial meningioma in patients aged more than 80 years: benefits and rationale. 61
33470146 2021
9
Determinants and predictors for the long-term disease burden of intracranial meningioma patients. 61
33073326 2021
10
Predicting meningioma consistency and brain-meningioma interface with intraoperative strain ultrasound elastography: a novel application to guide surgical strategy. 61
33386015 2021
11
Prediction of Meningioma WHO Grade Using PET Findings: A Systematic Review and Meta-Analysis. 61
33135239 2021
12
Effect of Surgeon Experience on Surgical Outcome of 80-Year-Old or Older Intracranial Meningioma Patients. 61
33422717 2021
13
Incidence and type of brain herniation associated with intracranial meningioma in dogs and cats. 61
33342961 2020
14
Long-Term Disease Burden and Survivorship Issues After Surgery and Radiotherapy of Intracranial Meningioma Patients. 61
32818258 2020
15
ACKT: A Proposal for a Novel Score to Predict Prolonged Mechanical Ventilation after Surgical Treatment of Meningioma in Geriatric Patients. 61
33396290 2020
16
Surgical treatment of rostrotentorial meningioma complicated by foraminal herniation in the cat. 61
32478635 2020
17
Clinical Outcome and Recurrence After Meningioma Surgery: An Experience from a Developing Country, Nepal. 61
33359878 2020
18
The Outcome of Intracranial Meningioma Surgery in Octogenarians: Matched Cohort Study. 61
32916350 2020
19
Mapping angiography and transarterial technetium macroaggregated albumin particle simulation of recurrent atypical intracranial meningioma: feasibility for potential vascular brachytherapy. 61
32983300 2020
20
Image-Guided Multisession Radiosurgery of Skull Base Meningiomas. 61
33260363 2020
21
A Grade I Intracranial Meningioma with Metastasis to Multiple Vertebral Bodies: A Case Report and Literature Review. 61
33329973 2020
22
Metastasis of pulmonary adenocarcinoma to right occipital parafalcine meningioma: A case report and literature review. 61
33126391 2020
23
Use of MRI increases interobserver agreement on gross tumor volume for imaging-diagnosed canine intracranial meningioma. 61
33090601 2020
24
Prognostic value of the Simpson grading scale in modern meningioma surgery: Barrow Neurological Institute experience. 61
33096534 2020
25
Frailty predicts worse outcomes after intracranial meningioma surgery irrespective of existing prognostic factors. 61
33002880 2020
26
Breast carcinoma metastasis in a resected meningioma with early diagnosis of oligometastatic disease: a case report. 61
33161726 2020
27
Estrogen hormone replacement therapy in incidental intracranial meningioma: a growth-rate analysis. 61
33087798 2020
28
Stereotactic Radiosurgery for Intracranial Noncavernous Sinus Benign Meningioma: International Stereotactic Radiosurgery Society Systematic Review, Meta-Analysis and Practice Guideline. 61
32463867 2020
29
Treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study. 61
33116194 2020
30
Intracranial meningioma and concomitant cavernous malformation: A series description and review of the literature. 61
32861039 2020
31
Risk factors for preoperative seizures in intracranial meningiomas. 61
33056948 2020
32
Intracranial Meningiomas in the Elderly: Clinical, Surgical and Economic Evaluation. A Multicentric Experience. 61
32962243 2020
33
Location and Diameter of Intracranial Meningioma as Predictors of Peritumoral Brain Oedema and Mass Effect. 61
32423785 2020
34
Response assessment of somatostatin receptor targeted radioligand therapies for progressive intracranial meningioma. 61
32691404 2020
35
Pre-surgical embolization of intracranial meningioma with Onyx: A safety and efficacy study. 61
31229578 2020
36
The effect of socioeconomic status on age at diagnosis and overall survival in patients with intracranial meningioma. 61
32878534 2020
37
Augmented reality in intracranial meningioma surgery: report of a case and systematic review. 61
32347678 2020
38
Socioeconomic burden and quality of life in meningioma patients. 61
32128657 2020
39
The Ki-67 Proliferation Index as a Marker of Time to Recurrence in Intracranial Meningioma. 61
32614441 2020
40
Central retinal artery occlusion combined with posterior ciliary artery occlusion after preoperative embolization of the middle meningeal artery for intracranial meningioma: A case report. 61
32664165 2020
41
Risk of tumor recurrence in intracranial meningiomas: comparative analyses of the predictive value of the postoperative tumor volume and the Simpson classification. 61
32679565 2020
42
Treatment Outcomes of Incidental Intracranial Meningiomas: Results from the IMPACT Cohort. 61
32200011 2020
43
Total DNA methylation as a biomarker of DNA damage and tumor malignancy in intracranial meningiomas. 61
32493231 2020
44
Meningioma with rhabdoid features combined with meningioangiomatosis in infancy: a novel combination. 61
31897634 2020
45
Differentiation of intracranial meningioma from dural metastasis with somatostatin receptor scintigraphy: An underutilised solution to a common problem. 61
31995193 2020
46
Anaplastic meningioma seeding of the abdominal wall following calvarial bone flap preservation. 61
32382362 2020
47
Return to work following meningioma surgery: a Swedish nationwide registry-based matched cohort study. 61
32528713 2020
48
DNA methylation profiling demonstrates superior diagnostic classification to RNA-sequencing in a case of metastatic meningioma. 61
32517746 2020
49
Association of Race with Survival in Intracranial World Health Organization Grade II and III Meningioma in the United States: Systematic Literature Review. 61
32142947 2020
50
Predictors of pre-operative cognitive impairment in meningioma patients over 60 years old. 61
32493294 2020

Variations for Intracranial Meningioma

Expression for Intracranial Meningioma

Search GEO for disease gene expression data for Intracranial Meningioma.

Pathways for Intracranial Meningioma

Pathways related to Intracranial Meningioma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.55 PCNA MSH2 MLH1 GSTP1 CDKN2A
2 12.42 MSH2 MLH1 IGF2 GSTP1 ESR1 DVL3
3
Show member pathways
12.4 PCNA MSH2 MGMT ESR1
4
Show member pathways
12.17 PGR MLH1 IGF2 GSTP1 ESR1 DVL3
5
Show member pathways
11.93 PGR ESR1 CDKN2A
6 11.77 PCNA MSH2 MLH1
7 11.68 MGMT IGF2 CDKN2A
8 11.64 PCNA MSH2 MLH1 MKI67 MGMT GSTP1
9
Show member pathways
11.59 PCNA MSH2 MLH1
10 11.49 MSH2 MLH1 GSTP1 CDKN2A
11
Show member pathways
11.2 MSH2 MLH1 MGMT GSTP1
12 11.04 PGR MLH1
13
Show member pathways
11.02 MGMT GSTP1
14 11.01 MSH2 MLH1 GSTP1

GO Terms for Intracranial Meningioma

Cellular components related to Intracranial Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.56 PGR PCNA MSH2 MLH1 MKI67 MGMT
2 condensed chromosome GO:0000793 9.16 MLH1 MKI67
3 mismatch repair complex GO:0032300 8.62 MSH2 MLH1

Biological processes related to Intracranial Meningioma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.93 PGR IGF2 ESR1 DVL3 CDKN2A
2 cellular response to DNA damage stimulus GO:0006974 9.81 PCNA MSH2 MLH1 MGMT
3 DNA repair GO:0006281 9.76 PCNA MSH2 MLH1 MGMT
4 response to estradiol GO:0032355 9.61 PCNA GSTP1 ESR1
5 positive regulation of DNA repair GO:0045739 9.55 PCNA MGMT
6 steroid hormone mediated signaling pathway GO:0043401 9.52 PGR ESR1
7 isotype switching GO:0045190 9.49 MSH2 MLH1
8 somatic hypermutation of immunoglobulin genes GO:0016446 9.48 MSH2 MLH1
9 protein localization to chromatin GO:0071168 9.4 MSH2 ESR1
10 intracellular steroid hormone receptor signaling pathway GO:0030518 9.37 PGR ESR1
11 positive regulation of isotype switching to IgG isotypes GO:0048304 9.32 MSH2 MLH1
12 positive regulation of isotype switching to IgA isotypes GO:0048298 9.26 MSH2 MLH1
13 somatic recombination of immunoglobulin gene segments GO:0016447 9.16 MSH2 MLH1
14 mismatch repair GO:0006298 9.13 PCNA MSH2 MLH1
15 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MSH2 MLH1

Molecular functions related to Intracranial Meningioma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.87 PGR PCNA MSH2 MKI67 MGMT ESR1
2 protein kinase binding GO:0019901 9.73 MSH2 GSTP1 ESR1 CDKN2A
3 chromatin binding GO:0003682 9.71 PCNA MSH2 MLH1 ESR1
4 protein C-terminus binding GO:0008022 9.67 PCNA MSH2 MKI67
5 steroid binding GO:0005496 9.48 PGR ESR1
6 steroid hormone receptor activity GO:0003707 9.46 PGR ESR1
7 mismatched DNA binding GO:0030983 9.37 MSH2 MLH1
8 MutLalpha complex binding GO:0032405 9.26 PCNA MSH2
9 guanine/thymine mispair binding GO:0032137 9.16 MSH2 MLH1
10 enzyme binding GO:0019899 9.02 PGR PCNA MSH2 MLH1 ESR1
11 dinucleotide insertion or deletion binding GO:0032139 8.96 PCNA MSH2

Sources for Intracranial Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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