Intracranial Primitive Neuroectodermal Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Intracranial Primitive Neuroectodermal Tumor

MalaCards integrated aliases for Intracranial Primitive Neuroectodermal Tumor:

Name: Intracranial Primitive Neuroectodermal Tumor ¹² ¹⁵

Intracranial Primitive Neuroectodermal Neoplasm ⁷³

Intracranial Pnet ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4788

NCIt ⁵⁰ C5817

UMLS ⁷³ C1334246

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Summaries for Intracranial Primitive Neuroectodermal Tumor

MalaCards based summary : Intracranial Primitive Neuroectodermal Tumor, also known as intracranial primitive neuroectodermal neoplasm, is related to adrenal medulla cancer and urinary bladder small cell neuroendocrine carcinoma. An important gene associated with Intracranial Primitive Neuroectodermal Tumor is SCG2 (Secretogranin II). Affiliated tissues include lung, skin and kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Intracranial Primitive Neuroectodermal Tumor

Diseases related to Intracranial Primitive Neuroectodermal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)

#	Related Disease	Score	Top Affiliating Genes
1	adrenal medulla cancer	10.1	CHGA SCG2
2	urinary bladder small cell neuroendocrine carcinoma	10.0	CHGA ENO2
3	auditory system cancer	10.0	CHGA ENO2
4	gallbladder small cell carcinoma	10.0	CHGA ENO2
5	small cell carcinoma	10.0	CHGA ENO2
6	small cell carcinoma of the bladder	10.0	CHGA ENO2
7	epithelioid malignant peripheral nerve sheath tumor	10.0	CHGA ENO2
8	lung oat cell carcinoma	10.0	CHGA ENO2
9	pulmonary large cell neuroendocrine carcinoma	10.0	CHGA ENO2
10	large cell neuroendocrine carcinoma	10.0	CHGA ENO2
11	atypical follicular adenoma	10.0	CHGA ENO2
12	goblet cell carcinoid	10.0	CHGA ENO2
13	cauda equina neoplasm	10.0	CHGA ENO2
14	acute thyroiditis	10.0	CHGA ENO2
15	olfactory nerve neoplasm	10.0	CHGA ENO2
16	autonomic nervous system benign neoplasm	10.0	CHGA ENO2
17	nodular ganglioneuroblastoma	10.0	CHGA ENO2
18	pineocytoma	10.0	CHGA ENO2
19	collagenous colitis	10.0	CHGA SCG2
20	gastric small cell carcinoma	10.0	CHGA ENO2
21	subependymoma	10.0	CHGA ENO2
22	carcinoid tumors, intestinal	10.0	CHGA ENO2
23	respiratory system benign neoplasm	10.0	CHGA ENO2
24	gastric squamous cell carcinoma	10.0	CHGA ENO2
25	somatostatinoma	10.0	CHGA ENO2
26	papillary ependymoma	10.0	CHGA ENO2
27	duodenal gastrinoma	10.0	CHGA ENO2
28	central neurocytoma	10.0	CHGA ENO2
29	carcinoid syndrome	10.0	CHGA ENO2
30	spinal meningioma	10.0	CHGA ENO2
31	spinal canal and spinal cord meningioma	10.0	CHGA ENO2
32	cervix small cell carcinoma	10.0	CHGA ENO2
33	diffuse pulmonary fibrosis	10.0	CHGA ENO2
34	cerebellar liponeurocytoma	10.0	CHGA ENO2
35	horseshoe kidney	10.0	CHGA ENO2
36	cranial nerve malignant neoplasm	10.0	CHGA ENO2
37	granulosa cell tumor of the ovary	10.0	CHGA ENO2
38	malignant pheochromocytoma	10.0	CHGA ENO2
39	olfactory neuroblastoma	10.0	CHGA ENO2
40	mixed ductal-endocrine carcinoma	10.0	CHGA ENO2
41	ganglioneuroma	10.0	CHGA ENO2
42	lung benign neoplasm	10.0	CHGA ENO2
43	kidney rhabdoid cancer	10.0	CD99 ENO2
44	ganglioglioma	10.0	CHGA ENO2
45	breast adenomyoepithelioma	9.9	CD99 ENO2
46	breast myoepithelial neoplasm	9.9	CD99 ENO2
47	extraskeletal ewing sarcoma	9.9	CD99 ENO2
48	large cell carcinoma	9.9	CHGA ENO2
49	merkel cell carcinoma	9.9	CHGA ENO2
50	paraganglioma	9.9	CHGA ENO2

Graphical network of the top 20 diseases related to Intracranial Primitive Neuroectodermal Tumor:

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Symptoms & Phenotypes for Intracranial Primitive Neuroectodermal Tumor

GenomeRNAi Phenotypes related to Intracranial Primitive Neuroectodermal Tumor according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-10	9.65	CD99
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-116	9.65	CHGA
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-181	9.65	CD99
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-20	9.65	CD99
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-213	9.65	CD99
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-53	9.65	CHGA
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-61	9.65	CD99 CHGA
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-65	9.65	CHGA
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-91	9.65	CD99
10	Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)	GR00196-A-1	8.8	CENPV CHGA SCG2

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Drugs & Therapeutics for Intracranial Primitive Neuroectodermal Tumor

Search Clinical Trials , NIH Clinical Center for Intracranial Primitive Neuroectodermal Tumor

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Genetic Tests for Intracranial Primitive Neuroectodermal Tumor

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Anatomical Context for Intracranial Primitive Neuroectodermal Tumor

MalaCards organs/tissues related to Intracranial Primitive Neuroectodermal Tumor:

⁴¹

Lung, Skin, Kidney, Bone, Ovary, Spinal Cord, Thyroid

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Publications for Intracranial Primitive Neuroectodermal Tumor

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Genes for Intracranial Primitive Neuroectodermal Tumor

Genes related to Intracranial Primitive Neuroectodermal Tumor (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SCG2	Secretogranin II	Protein Coding	15.99	DISEASES inferred ¹⁵
2	ENO2	Enolase 2	Protein Coding	14.22	DISEASES inferred ¹⁵
3	CHGA	Chromogranin A	Protein Coding	14.21	DISEASES inferred ¹⁵
4	CD99	CD99 Molecule (Xg Blood Group)	Protein Coding	6.44	DISEASES inferred ¹⁵
5	CENPV	Centromere Protein V	Protein Coding	6.01	DISEASES inferred ¹⁵

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Variations for Intracranial Primitive Neuroectodermal Tumor

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Expression for Intracranial Primitive Neuroectodermal Tumor

Search GEO for disease gene expression data for Intracranial Primitive Neuroectodermal Tumor.

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Pathways for Intracranial Primitive Neuroectodermal Tumor

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GO Terms for Intracranial Primitive Neuroectodermal Tumor

Cellular components related to Intracranial Primitive Neuroectodermal Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule	GO:0030141	8.62	CHGA SCG2

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Sources for Intracranial Primitive Neuroectodermal Tumor

¹ BioSystems

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