MCID: INT022
MIFTS: 21

Intracranial Primitive Neuroectodermal Tumor

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Intracranial Primitive Neuroectodermal Tumor

MalaCards integrated aliases for Intracranial Primitive Neuroectodermal Tumor:

Name: Intracranial Primitive Neuroectodermal Tumor 12 15
Intracranial Primitive Neuroectodermal Neoplasm 73
Intracranial Pnet 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4788
NCIt 50 C5817
UMLS 73 C1334246

Summaries for Intracranial Primitive Neuroectodermal Tumor

MalaCards based summary : Intracranial Primitive Neuroectodermal Tumor, also known as intracranial primitive neuroectodermal neoplasm, is related to adrenal medulla cancer and urinary bladder small cell neuroendocrine carcinoma. An important gene associated with Intracranial Primitive Neuroectodermal Tumor is SCG2 (Secretogranin II). Affiliated tissues include lung, skin and kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Intracranial Primitive Neuroectodermal Tumor

Diseases related to Intracranial Primitive Neuroectodermal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 adrenal medulla cancer 10.1 CHGA SCG2
2 urinary bladder small cell neuroendocrine carcinoma 10.0 CHGA ENO2
3 auditory system cancer 10.0 CHGA ENO2
4 gallbladder small cell carcinoma 10.0 CHGA ENO2
5 small cell carcinoma 10.0 CHGA ENO2
6 small cell carcinoma of the bladder 10.0 CHGA ENO2
7 epithelioid malignant peripheral nerve sheath tumor 10.0 CHGA ENO2
8 lung oat cell carcinoma 10.0 CHGA ENO2
9 pulmonary large cell neuroendocrine carcinoma 10.0 CHGA ENO2
10 large cell neuroendocrine carcinoma 10.0 CHGA ENO2
11 atypical follicular adenoma 10.0 CHGA ENO2
12 goblet cell carcinoid 10.0 CHGA ENO2
13 cauda equina neoplasm 10.0 CHGA ENO2
14 acute thyroiditis 10.0 CHGA ENO2
15 olfactory nerve neoplasm 10.0 CHGA ENO2
16 autonomic nervous system benign neoplasm 10.0 CHGA ENO2
17 nodular ganglioneuroblastoma 10.0 CHGA ENO2
18 pineocytoma 10.0 CHGA ENO2
19 collagenous colitis 10.0 CHGA SCG2
20 gastric small cell carcinoma 10.0 CHGA ENO2
21 subependymoma 10.0 CHGA ENO2
22 carcinoid tumors, intestinal 10.0 CHGA ENO2
23 respiratory system benign neoplasm 10.0 CHGA ENO2
24 gastric squamous cell carcinoma 10.0 CHGA ENO2
25 somatostatinoma 10.0 CHGA ENO2
26 papillary ependymoma 10.0 CHGA ENO2
27 duodenal gastrinoma 10.0 CHGA ENO2
28 central neurocytoma 10.0 CHGA ENO2
29 carcinoid syndrome 10.0 CHGA ENO2
30 spinal meningioma 10.0 CHGA ENO2
31 spinal canal and spinal cord meningioma 10.0 CHGA ENO2
32 cervix small cell carcinoma 10.0 CHGA ENO2
33 diffuse pulmonary fibrosis 10.0 CHGA ENO2
34 cerebellar liponeurocytoma 10.0 CHGA ENO2
35 horseshoe kidney 10.0 CHGA ENO2
36 cranial nerve malignant neoplasm 10.0 CHGA ENO2
37 granulosa cell tumor of the ovary 10.0 CHGA ENO2
38 malignant pheochromocytoma 10.0 CHGA ENO2
39 olfactory neuroblastoma 10.0 CHGA ENO2
40 mixed ductal-endocrine carcinoma 10.0 CHGA ENO2
41 ganglioneuroma 10.0 CHGA ENO2
42 lung benign neoplasm 10.0 CHGA ENO2
43 kidney rhabdoid cancer 10.0 CD99 ENO2
44 ganglioglioma 10.0 CHGA ENO2
45 breast adenomyoepithelioma 9.9 CD99 ENO2
46 breast myoepithelial neoplasm 9.9 CD99 ENO2
47 extraskeletal ewing sarcoma 9.9 CD99 ENO2
48 large cell carcinoma 9.9 CHGA ENO2
49 merkel cell carcinoma 9.9 CHGA ENO2
50 paraganglioma 9.9 CHGA ENO2

Graphical network of the top 20 diseases related to Intracranial Primitive Neuroectodermal Tumor:



Diseases related to Intracranial Primitive Neuroectodermal Tumor

Symptoms & Phenotypes for Intracranial Primitive Neuroectodermal Tumor

GenomeRNAi Phenotypes related to Intracranial Primitive Neuroectodermal Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.65 CD99
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.65 CHGA
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.65 CD99
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.65 CD99
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.65 CD99
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.65 CHGA
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.65 CD99 CHGA
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.65 CHGA
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.65 CD99
10 Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells) GR00196-A-1 8.8 CENPV CHGA SCG2

Drugs & Therapeutics for Intracranial Primitive Neuroectodermal Tumor

Search Clinical Trials , NIH Clinical Center for Intracranial Primitive Neuroectodermal Tumor

Genetic Tests for Intracranial Primitive Neuroectodermal Tumor

Anatomical Context for Intracranial Primitive Neuroectodermal Tumor

MalaCards organs/tissues related to Intracranial Primitive Neuroectodermal Tumor:

41
Lung, Skin, Kidney, Bone, Ovary, Spinal Cord, Thyroid

Publications for Intracranial Primitive Neuroectodermal Tumor

Variations for Intracranial Primitive Neuroectodermal Tumor

Expression for Intracranial Primitive Neuroectodermal Tumor

Search GEO for disease gene expression data for Intracranial Primitive Neuroectodermal Tumor.

Pathways for Intracranial Primitive Neuroectodermal Tumor

GO Terms for Intracranial Primitive Neuroectodermal Tumor

Cellular components related to Intracranial Primitive Neuroectodermal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.62 CHGA SCG2

Sources for Intracranial Primitive Neuroectodermal Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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