MCID: INT076
MIFTS: 30

Intracranial Sinus Thrombosis

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Intracranial Sinus Thrombosis

MalaCards integrated aliases for Intracranial Sinus Thrombosis:

Name: Intracranial Sinus Thrombosis 12 15
Sinus Thrombosis, Intracranial 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3572
MeSH 44 D012851
UMLS 70 C0037198

Summaries for Intracranial Sinus Thrombosis

MalaCards based summary : Intracranial Sinus Thrombosis, also known as sinus thrombosis, intracranial, is related to abdominal tuberculosis and intracranial hypertension. An important gene associated with Intracranial Sinus Thrombosis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Dalteparin and Heparin have been mentioned in the context of this disorder.

Related Diseases for Intracranial Sinus Thrombosis

Diseases related to Intracranial Sinus Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 274)
# Related Disease Score Top Affiliating Genes
1 abdominal tuberculosis 30.3 F2 CRP
2 intracranial hypertension 29.9 SERPINC1 MTHFR F3 F2
3 thrombosis 29.7 SERPINC1 PLG MTHFR F8 F3 F2
4 thrombophilia 29.6 SERPINC1 MTHFR F8 F3 F2
5 cerebrovascular disease 29.6 MTHFR F8 F2 CRP
6 inflammatory bowel disease 29.5 SERPINC1 MTHFR F3 F2 CRP
7 sagittal sinus thrombosis 29.0 SERPINC1 PLG MICU2 F8 F3 F2
8 heparin-induced thrombocytopenia 10.3 SERPINC1 F3
9 vulvar angiokeratoma 10.3 SERPINC1 F3
10 papillary adenofibroma 10.3 F3 F2
11 orbital osteomyelitis 10.3 F2 CRP
12 femoral neuropathy 10.3 F3 F2
13 arteritic anterior ischemic optic neuropathy 10.3 MTHFR F2
14 small intestine diverticulitis 10.3 F2 CRP
15 blue toe syndrome 10.3 SERPINC1 CRP
16 hemopneumothorax 10.3 F3 F2
17 prothrombin deficiency, congenital 10.3 SERPINC1 F2
18 pulmonary embolism and infarction 10.3 F3 F2
19 hematocele of tunica vaginalis testis 10.3 F2 CRP
20 gastric hemangioma 10.3 F3 F2
21 qualitative platelet defect 10.3 F3 F2
22 subdural empyema 10.3 F2 CRP
23 internal hemorrhoid 10.3 F2 CRP
24 hemorrhoid 10.3 F2 CRP
25 acalculous cholecystitis 10.3 F2 CRP
26 splenic abscess 10.3 F2 CRP
27 subclavian steal syndrome 10.3 F3 CRP
28 sudden sensorineural hearing loss 10.3 MTHFR F2
29 ascending cholangitis 10.3 F2 CRP
30 early congenital syphilis 10.3 F2 CRP
31 splenic sequestration 10.3 F3 F2
32 prothrombin thrombophilia 10.3 MTHFR F2
33 cauda equina syndrome 10.3 F2 CRP
34 splenic tuberculosis 10.3 F2 CRP
35 paralytic ileus 10.3 F2 CRP
36 acute cholangitis 10.3 F2 CRP
37 acute hemorrhagic encephalitis 10.3 F3 F2
38 critical illness polyneuropathy 10.3 F3 CRP
39 vulvar benign neoplasm 10.3 SERPINC1 F3
40 common bile duct disease 10.3 F2 CRP
41 aspiration pneumonitis 10.3 F3 CRP
42 syphilitic meningitis 10.3 SERPINC1 CRP
43 cranial nerve palsy 10.3 SERPINC1 CRP
44 anterior spinal artery syndrome 10.3 PLG F2
45 medulloadrenal hyperfunction 10.3 PLG F3
46 pyuria 10.3 F2 CRP
47 basilar artery occlusion 10.3 PLG F2
48 catastrophic antiphospholipid syndrome 10.3 MTHFR F3
49 kwashiorkor 10.3 F2 CRP
50 hantavirus pulmonary syndrome 10.3 F3 F2

Graphical network of the top 20 diseases related to Intracranial Sinus Thrombosis:



Diseases related to Intracranial Sinus Thrombosis

Symptoms & Phenotypes for Intracranial Sinus Thrombosis

Drugs & Therapeutics for Intracranial Sinus Thrombosis

Drugs for Intracranial Sinus Thrombosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dalteparin Approved Phase 4 9005-49-6
2
Heparin Approved, Investigational Phase 4 9005-49-6 772 9812414
3
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
4
Batroxobin Experimental Phase 4 9039-61-6
5 Anticoagulants Phase 4
6 Fibrinolytic Agents Phase 4
7 Heparin, Low-Molecular-Weight Phase 4
8 calcium heparin Phase 4
9 Coagulants Phase 4
10 Hemostatics Phase 4
11
Warfarin Approved Phase 3 81-81-2 54678486 6691
12
Dabigatran Investigational Phase 3 211914-51-1
13 Serine Proteinase Inhibitors Phase 3
14 Antithrombin III Phase 3
15
protease inhibitors Phase 3
16 Antithrombins Phase 3
17 HIV Protease Inhibitors Phase 3
18 Tissue Plasminogen Activator Phase 2, Phase 3
19
Serine Investigational, Nutraceutical Phase 3 56-45-1 5951
20 abobotulinumtoxinA Phase 1
21 Botulinum Toxins, Type A Phase 1
22 Botulinum Toxins Phase 1
23
Ethinyl Estradiol Approved 57-63-6 5991
24
Ferrous fumarate Approved 141-01-5
25
Polyestradiol phosphate Approved 28014-46-2
26
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
27
Levonorgestrel Approved, Investigational 797-63-7, 17489-40-6 13109
28
Norethindrone Approved 68-22-4 6230
29
Metronidazole Approved 443-48-1 4173
30 Ethinyl estradiol, levonorgestrel drug combination
31 Contraceptives, Oral, Hormonal
32 Contraceptive Agents
33 Estradiol 3-benzoate
34 Contraceptives, Oral
35 Hormone Antagonists
36 Contraceptives, Oral, Combined
37 Hormones
38 Estradiol 17 beta-cypionate
39 Norinyl
40 Estrogens
41 Norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination
42 Norethindrone Acetate

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 The Efficacy and Safety of Batroxobin Combined With Anticoagulation in Cerebral Venous Sinus Thrombosis Not yet recruiting NCT04269954 Phase 4 Batroxobin combined with low molecular weight heparin
2 RE-SPECT CVT: a Randomised, Open-label, Exploratory Trial With Blinded Endpoint Adjudication (PROBE), Comparing Efficacy and Safety of Oral Dabigatran Etexilate Versus Oral Warfarin in Patients With Cerebral Venous and Dural Sinus Thrombosis Over a 24-week Period Completed NCT02913326 Phase 3 Dabigatran etexilate;Warfarin
3 Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis (TOACT) Terminated NCT01204333 Phase 2, Phase 3 Endovascular thrombolysis;Heparin
4 Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache Not yet recruiting NCT04580238 Phase 1 Botox 200 UNT Injection
5 Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment Unknown status NCT03273179
6 Otogenic Cerebral Sinus Vein Thrombosis in Children: Retrospective Case Series and Associated Thrombophilia Completed NCT03864055
7 Comparison of the Radiological Pattern Between the Cerebral Stroke of Arterial and Venous Origin Completed NCT03611894
8 Postmarketing Study Of Lybrel In Relation To Venous Thromboembolism Completed NCT01297348 90ug levonorgestrel / 20 ug ethinyl estradiol;Oral Contraceptives containing 20 ug of ethinyl estradiol
9 Safety and Feasibility of the Infinity Guide Catheter for Neuro Interventional Procedures Using Transradial Access Recruiting NCT04553549
10 Stroke and Cerebrovascular Diseases Registry Recruiting NCT03281590
11 Cerebral Venous Thrombosis Cohort Study in China Mainland Not yet recruiting NCT03919305

Search NIH Clinical Center for Intracranial Sinus Thrombosis

Cochrane evidence based reviews: sinus thrombosis, intracranial

Genetic Tests for Intracranial Sinus Thrombosis

Anatomical Context for Intracranial Sinus Thrombosis

Publications for Intracranial Sinus Thrombosis

Articles related to Intracranial Sinus Thrombosis:

(show all 27)
# Title Authors PMID Year
1
Predicting Anticoagulation Need for Otogenic Intracranial Sinus Thrombosis: A Machine Learning Approach. 61
33777638 2021
2
Polyradiculopathy and Multiple Cranial Nerve Palsies - Rare Manifestations of Cerebral Venous Sinus Thrombosis. 61
33642294 2021
3
Successful treatment of a massive sinus thrombosis in a Chinese woman with antithrombin III deficiency: a case report and review of the literature. 61
32815917 2020
4
Management of a decompensated acute-on-chronic intracranial venous sinus thrombosis. 61
31903097 2019
5
[Behcet's disease with neurologic manifestations]. 61
31793546 2019
6
A Case of Deep Vein Thrombosis and Intracranial Sinus Thrombosis: Possible rare complications of childhood abdominal tuberculosis. 61
28003904 2016
7
[Cerebral vein thrombosis secondary to closed head injury. Report of one case]. 61
24728440 2013
8
Low molecular weight heparin therapy in pediatric otogenic sigmoid sinus thrombosis: a safe treatment option? 61
22521337 2012
9
Transverse sinus thrombosis associated with otitis media and mastoiditis. 61
22747873 2012
10
[Intracranial sinus thrombosis secondary to the consumption of inhaled speed]. 61
22127914 2011
11
WITHDRAWN: Intracranial Sinus Thrombosis in Anorexia Nervosa. 61
20659740 2010
12
Successful management of an extensive intracranial sinus thrombosis in a patient undergoing IVF: case report and review of literature. 61
17349640 2007
13
Benign intracranial hypertension associated to blood coagulation derangements. 61
17187688 2006
14
Aseptic meningitis, venous sinus thrombosis, intracranial hypertension and callosal involvement contemporaneously in a young patient with Behçet's disease. 61
16453209 2005
15
Cerebral sinus thrombosis in patients with inflammatory bowel disease: a case report. 61
16149158 2005
16
[Sepsis and multiple organ failure after BCG instillation in bladder cancer]. 61
15645554 2004
17
[Sepsis and multiple organ failure after BCG-instillation for bladder cancer]. 61
15138643 2004
18
Intracranial sinus thrombosis in a patient with Crohn disease and factor V Leiden mutation. 61
12873183 2003
19
Thunderclap headache: presentation of intracranial sinus thrombosis? 61
12887960 2003
20
Sigmoid sinus thrombosis after mild closed head injury in an infant: diagnosis by magnetic resonance imaging in the acute phase--case report. 61
10927903 2000
21
[Symptomatic psychosis in bland sinus thrombosis and antibiotic therapy]. 61
10457975 1999
22
Reversibility of severe sagittal sinus thrombosis with open surgical thrombectomy combined with local infusion of tissue plasminogen activator: technical case report. 61
9766329 1998
23
Intracranial sinus thrombosis secondary to ear disease in an adolescent. 61
9176806 1997
24
Open thrombectomy combined with thrombolysis in massive intracranial sinus thrombosis. 61
7847137 1994
25
Septic cavernous and lateral sinus thrombosis: modern diagnostic and therapeutic principles. 61
3058845 1988
26
Cerebral infarction due to intracranial sinus thrombosis. 61
5835445 1965
27
[INTRACRANIAL SINUS THROMBOSIS IN PREGNANCY]. 61
14053183 1963

Variations for Intracranial Sinus Thrombosis

Expression for Intracranial Sinus Thrombosis

Search GEO for disease gene expression data for Intracranial Sinus Thrombosis.

Pathways for Intracranial Sinus Thrombosis

Pathways related to Intracranial Sinus Thrombosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 SERPINC1 PLG F8 F3 F2
2
Show member pathways
12.36 SERPINC1 F8 F3 F2
3
Show member pathways
11.79 PLG MTHFR F2 CRP
4
Show member pathways
11.56 SERPINC1 PLG F8 F3 F2
5 11.18 SERPINC1 PLG F8 F3 F2
6 10.9 PLG F2
7 10.58 PLG F2

GO Terms for Intracranial Sinus Thrombosis

Cellular components related to Intracranial Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 SERPINC1 PLG F8 F3 F2 CRP
2 blood microparticle GO:0072562 9.13 SERPINC1 PLG F2
3 collagen-containing extracellular matrix GO:0062023 8.92 SERPINC1 PLG F3 F2

Biological processes related to Intracranial Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.61 SERPINC1 PLG F2
2 fibrinolysis GO:0042730 9.4 PLG F2
3 blood coagulation, intrinsic pathway GO:0007597 9.37 F8 F2
4 blood coagulation GO:0007596 9.35 SERPINC1 PLG F8 F3 F2
5 acute-phase response GO:0006953 9.33 F8 F2 CRP
6 regulation of blood coagulation GO:0030193 9.32 SERPINC1 F2
7 negative regulation of fibrinolysis GO:0051918 9.26 PLG F2
8 hemostasis GO:0007599 9.02 SERPINC1 PLG F8 F3 F2

Molecular functions related to Intracranial Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 PLG F3 F2

Sources for Intracranial Sinus Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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