MCID: INT078
MIFTS: 37

Intracranial Thrombosis

Categories: Cardiovascular diseases, Neuronal diseases, Blood diseases

Aliases & Classifications for Intracranial Thrombosis

MalaCards integrated aliases for Intracranial Thrombosis:

Name: Intracranial Thrombosis 12 44 15 73
Cerebral Thrombosis 12 76 55 73
Thrombosis of Cerebral Veins 73
Cerebral Arterial Thrombosis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4193
ICD9CM 35 434.0
MeSH 44 D020767
SNOMED-CT 68 155401002

Summaries for Intracranial Thrombosis

MalaCards based summary : Intracranial Thrombosis, also known as cerebral thrombosis, is related to thrombosis and sticky platelet syndrome. An important gene associated with Intracranial Thrombosis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Warfarin and Dalteparin have been mentioned in the context of this disorder. Related phenotypes are homeostasis/metabolism and mortality/aging

Wikipedia : 76 A thrombus, colloquially called a blood clot, is the final product of the blood coagulation step in... more...

Related Diseases for Intracranial Thrombosis

Diseases related to Intracranial Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 thrombosis 26.8 APOH F3 F5 MTHFR SERPINC1 VWF
2 sticky platelet syndrome 10.6 F5 SERPINC1
3 may-thurner syndrome 10.6 APOH F5
4 acanthamoeba keratitis 10.6 APOH F5
5 pregnancy loss, recurrent 1 10.6 APOH F5
6 meningococcemia 10.5 F5 SERPINC1
7 legg-calve-perthes disease 10.5 F5 SERPINC1
8 breast reconstruction 10.5 APOH F8
9 factor v and factor viii, combined deficiency of, 2 10.5 F5 F8
10 intestinal impaction 10.5 F3 SERPINC1
11 heparin-induced thrombocytopenia 10.5 F3 SERPINC1
12 leech infestation 10.4 F3 SERPINC1
13 giant hemangioma 10.4 F3 SERPINC1
14 blue toe syndrome 10.4 F3 SERPINC1
15 intracranial embolism 10.4 F3 SERPINC1
16 purpura fulminans 10.4 F3 SERPINC1
17 inferior vena cava interruption 10.3 F5 MTHFR
18 amaurosis fugax 10.3 F5 MTHFR
19 blood protein disease 10.3 MTHFR SERPINC1
20 hemorrhagic fever 10.3 F3 SERPINC1
21 prothrombin deficiency, congenital 10.3 APOH F5 SERPINC1
22 ischemic colitis 10.3 APOH F5 SERPINC1
23 sneddon syndrome 10.3 APOH F5 SERPINC1
24 intermediate coronary syndrome 10.3 F3 SERPINC1
25 cerebritis 10.3
26 pulmonary immaturity 10.3 F3 SERPINC1
27 severe pre-eclampsia 10.3 APOH F5 SERPINC1
28 cryptogenic cirrhosis 10.2 F5 MTHFR
29 factor xi deficiency 10.2 F3 SERPINC1
30 dysfibrinogenemia 10.2 F5 FGA SERPINC1
31 alcohol-related birth defect 10.2 F3 F8
32 porencephaly 10.2 F5 MTHFR
33 post-thrombotic syndrome 10.2 F5 F8 SERPINC1
34 multicentric castleman disease 10.2 F3 F8
35 buerger disease 10.2 APOH MTHFR
36 behcet syndrome 10.2 APOH F5 SERPINC1
37 acute respiratory distress syndrome 10.1 F5 PLA2G7
38 carotid artery occlusion 10.1 APOH F5 F8
39 sagittal sinus thrombosis 10.1 F3 F5 SERPINC1
40 hepatitis a 10.1 F3 SERPINC1
41 arteritic anterior ischemic optic neuropathy 10.1 F5 MTHFR
42 cerebral sinovenous thrombosis 10.1 APOH F3 F5
43 platelet aggregation, spontaneous 10.1 SERPINC1 VWF
44 factor vii deficiency 10.0 F3 F8
45 sudden sensorineural hearing loss 10.0 F5 MTHFR SERPINC1
46 fournier gangrene 10.0 F3 F8 SERPINC1
47 schizencephaly 10.0 F5 MTHFR
48 patent foramen ovale 10.0 F5 MTHFR SERPINC1
49 protein c deficiency 10.0 F5 MTHFR SERPINC1
50 acquired hemophilia a 10.0 F3 F5 F8

Comorbidity relations with Intracranial Thrombosis via Phenotypic Disease Network (PDN): (show all 21)


Active Peptic Ulcer Disease Acute Cystitis
Aortic Valve Disease 1 Benign Essential Hypertension
Cerebral Atherosclerosis Cerebrovascular Disease
Chronic Myocardial Ischemia Decubitus Ulcer
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intracranial Embolism
Ischemic Heart Disease Malignant Essential Hypertension
Peripheral Vascular Disease Schizophreniform Disorder
Spastic Hemiplegia Swallowing Disorders
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Intracranial Thrombosis:



Diseases related to Intracranial Thrombosis

Symptoms & Phenotypes for Intracranial Thrombosis

MGI Mouse Phenotypes related to Intracranial Thrombosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.56 APOH F3 F5 F8 FGA MTHFR
2 mortality/aging MP:0010768 9.28 F3 F5 F8 FGA MTHFR PLA2G7

Drugs & Therapeutics for Intracranial Thrombosis

Drugs for Intracranial Thrombosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved Phase 3 81-81-2 6691 54678486
2
Dalteparin Approved Phase 2, Phase 3 9005-49-6
3
Heparin Approved, Investigational Phase 2, Phase 3 9005-49-6 772 46507594
4
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
5 Anticoagulants Phase 3,Phase 2
6 Antithrombin III Phase 3
7 Antithrombins Phase 3
8 Dabigatran Phase 3
9 HIV Protease Inhibitors Phase 3
10
protease inhibitors Phase 3
11 Serine Proteinase Inhibitors Phase 3
12 calcium heparin Phase 2, Phase 3
13 Calcium, Dietary Phase 2, Phase 3
14 Fibrinolytic Agents Phase 2, Phase 3
15 Heparin, Low-Molecular-Weight Phase 2, Phase 3
16 Plasminogen Phase 2, Phase 3
17 Tissue Plasminogen Activator Phase 2, Phase 3
18
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
19 Estradiol valerate Approved, Investigational, Vet_approved 979-32-8
20
Ethinyl Estradiol Approved 57-63-6 5991
21
Levonorgestrel Approved, Investigational 797-63-7, 17489-40-6 13109
22
Polyestradiol phosphate Approved 28014-46-2
23 Contraceptive Agents
24 Contraceptives, Oral
25 Contraceptives, Oral, Combined
26 Estradiol 17 beta-cypionate
27 Estradiol 3-benzoate
28 Estrogens
29 Ethinyl estradiol, levonorgestrel drug combination
30 Hormone Antagonists
31 Hormones
32 Hormones, Hormone Substitutes, and Hormone Antagonists
33 Norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination
34 Norinyl

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Clinical Trial Comparing Efficacy and Safety of Dabigatran Etexilate With Warfarin in Patients With Cerebral Venous and Dural Sinus Thrombosis (RE-SPECT CVT) Completed NCT02913326 Phase 3 Dabigatran etexilate;Warfarin
2 Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis Terminated NCT01204333 Phase 2, Phase 3 Endovascular thrombolysis;Heparin
3 Prevention for the Restenosis of Intracranial Artery Stent Implantation Treated With Herbal Medicine C117 Not yet recruiting NCT03008798 Phase 2 Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
4 Modern Ultrasound Techniques in the Evaluation of Cerebral Venous Sinuses in Neonates Completed NCT00555932 Not Applicable
5 Study Of Lybrel In Relation To Venous Thromboembolism Completed NCT01297348 90ug levonorgestrel / 20 ug ethinyl estradiol;Oral Contraceptives containing 20 ug of ethinyl estradiol
6 Impact of Cranioplasty On Cerebral Perfusion Completed NCT01113645
7 Stroke and Cerebrovascular Diseases Registry Recruiting NCT03281590
8 Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment Scales Recruiting NCT03273179

Search NIH Clinical Center for Intracranial Thrombosis

Cochrane evidence based reviews: intracranial thrombosis

Genetic Tests for Intracranial Thrombosis

Anatomical Context for Intracranial Thrombosis

Publications for Intracranial Thrombosis

Articles related to Intracranial Thrombosis:

# Title Authors Year
1
Extension of intracranial thrombosis after unilateral dissection of the internal jugular vein. ( 15897422 )
2005
2
Letter: Tranexamic acid and intracranial thrombosis. ( 59118 )
1976
3
Intracranial thrombosis of the internal carotid artery after closed head injury. ( 5360046 )
1969
4
ON INTRACRANIAL THROMBOSIS AS THE CAUSE OF DOUBLE OPTIC NEURITIS IN CASES OF CHLOROSIS. ( 20760046 )
1902

Variations for Intracranial Thrombosis

Expression for Intracranial Thrombosis

Search GEO for disease gene expression data for Intracranial Thrombosis.

Pathways for Intracranial Thrombosis

GO Terms for Intracranial Thrombosis

Cellular components related to Intracranial Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 APOH F3 F5 F8 FGA PLA2G7
2 extracellular region GO:0005576 9.76 APOH F3 F5 F8 FGA PLA2G7
3 endoplasmic reticulum lumen GO:0005788 9.62 F5 F8 FGA SERPINC1
4 extracellular matrix GO:0031012 9.54 APOH F3 VWF
5 extracellular vesicle GO:1903561 9.43 F5 FGA
6 COPII-coated ER to Golgi transport vesicle GO:0030134 9.4 F5 F8
7 platelet alpha granule GO:0031091 9.13 F5 FGA VWF
8 platelet alpha granule lumen GO:0031093 8.92 F5 F8 FGA VWF

Biological processes related to Intracranial Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.61 F5 FGA SERPINC1
2 platelet degranulation GO:0002576 9.55 APOH F5 F8 FGA VWF
3 platelet activation GO:0030168 9.5 F8 FGA VWF
4 blood circulation GO:0008015 9.46 F5 MTHFR
5 blood coagulation, intrinsic pathway GO:0007597 9.43 APOH F8 VWF
6 blood coagulation GO:0007596 9.43 F3 F5 F8 FGA SERPINC1 VWF
7 plasminogen activation GO:0031639 9.4 APOH FGA
8 regulation of blood coagulation GO:0030193 9.37 APOH SERPINC1
9 hemostasis GO:0007599 9.1 F3 F5 F8 FGA SERPINC1 VWF

Molecular functions related to Intracranial Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 9.16 F5 F8
2 phospholipid binding GO:0005543 9.13 APOH F3 PLA2G7
3 protease binding GO:0002020 8.8 F3 SERPINC1 VWF

Sources for Intracranial Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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