MCID: INT078
MIFTS: 46

Intracranial Thrombosis

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Intracranial Thrombosis

MalaCards integrated aliases for Intracranial Thrombosis:

Name: Intracranial Thrombosis 12 44 15 73
Cerebral Thrombosis 12 76 55 73
Thrombosis of Cerebral Veins 73
Cerebral Arterial Thrombosis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4193
ICD9CM 35 434.0
MeSH 44 D020767

Summaries for Intracranial Thrombosis

MalaCards based summary : Intracranial Thrombosis, also known as cerebral thrombosis, is related to heparin-induced thrombocytopenia and protein s deficiency. An important gene associated with Intracranial Thrombosis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Warfarin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and spinal cord, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 76 A thrombus, colloquially called a blood clot, is the final product of the blood coagulation step in... more...

Related Diseases for Intracranial Thrombosis

Diseases related to Intracranial Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 187)
# Related Disease Score Top Affiliating Genes
1 heparin-induced thrombocytopenia 29.8 F3 SERPINC1
2 protein s deficiency 29.5 APOH F3 F5 MTHFR SERPINC1
3 factor xiii deficiency 29.5 F3 F5 F8
4 protein c deficiency 29.5 F5 MTHFR SERPINC1
5 homocystinuria 29.5 F5 MTHFR SERPINC1
6 intracranial embolism 29.5 PLG SERPINC1
7 thrombocytopenia 29.4 APOH F3 ITGA2B
8 antithrombin iii deficiency 29.4 APOH F5 MTHFR SERPINC1
9 placental abruption 29.4 APOH F5 MTHFR SERPINC1
10 thrombosis 29.2 APOH F3 F5 F8 MTHFR SERPINC1
11 acute myocardial infarction 29.1 F3 ITGA2B PLG SERPINC1 VWF
12 heart disease 29.0 F3 F8 MTHFR SERPINC1 VWF
13 antiphospholipid syndrome 29.0 APOH F3 F5 MTHFR SERPINC1 VWF
14 pulmonary embolism 29.0 APOH F3 F5 MTHFR SERPINC1 VWF
15 myocardial infarction 28.1 F3 F5 F8 FGA ITGA2B MTHFR
16 hemorrhagic fever 10.3 F3 SERPINC1
17 may-thurner syndrome 10.2 APOH F5
18 sticky platelet syndrome 10.2 F5 SERPINC1
19 acanthamoeba keratitis 10.2 APOH F5
20 pregnancy loss, recurrent 1 10.2 APOH F5
21 sneddon syndrome 10.2 APOH SERPINC1
22 meningococcemia 10.2 F5 SERPINC1
23 platelet aggregation, spontaneous 10.2 SERPINC1 VWF
24 purpura fulminans 10.2 F3 SERPINC1
25 breast reconstruction 10.2 APOH F8
26 factor v and factor viii, combined deficiency of, 2 10.2 F5 F8
27 qualitative platelet defect 10.2 F3 VWF
28 arteritic anterior ischemic optic neuropathy 10.2 F5 MTHFR
29 inferior vena cava interruption 10.2 F5 MTHFR
30 aspirin allergy 10.2 ITGA2B SERPINC1
31 amaurosis fugax 10.2 F5 MTHFR
32 prothrombin deficiency, congenital 10.1 APOH F5 SERPINC1
33 ischemic colitis 10.1 APOH F5 SERPINC1
34 raynaud phenomenon 10.1 APOH VWF
35 legg-calve-perthes disease 10.1 APOH F5 SERPINC1
36 fainting 10.1 F8 VWF
37 alcohol-related birth defect 10.1 F3 F8
38 sagittal sinus thrombosis 10.1 F3 F5 SERPINC1
39 cryptogenic cirrhosis 10.1 F5 MTHFR
40 severe pre-eclampsia 10.1 APOH F5 SERPINC1
41 porencephaly 10.1 F5 MTHFR
42 pulmonary immaturity 10.1 F3 SERPINC1
43 cerebral sinovenous thrombosis 10.1 APOH F3 F5
44 acquired von willebrand syndrome 10.1 F8 VWF
45 dysfibrinogenemia 10.1 F5 FGA SERPINC1
46 brachydactyly, type d 10.1 F8 VWF
47 factor xi deficiency 10.1 F3 SERPINC1
48 carotid artery thrombosis 10.1 F3 ITGA2B
49 hemarthrosis 10.1 F8 VWF
50 behcet syndrome 10.1 APOH F5 SERPINC1

Comorbidity relations with Intracranial Thrombosis via Phenotypic Disease Network (PDN): (show all 21)


Active Peptic Ulcer Disease Acute Cystitis
Aortic Valve Disease 1 Benign Essential Hypertension
Cerebral Atherosclerosis Cerebrovascular Disease
Chronic Myocardial Ischemia Decubitus Ulcer
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intracranial Embolism
Ischemic Heart Disease Malignant Essential Hypertension
Peripheral Vascular Disease Schizophreniform Disorder
Spastic Hemiplegia Swallowing Disorders
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Intracranial Thrombosis:



Diseases related to Intracranial Thrombosis

Symptoms & Phenotypes for Intracranial Thrombosis

MGI Mouse Phenotypes related to Intracranial Thrombosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 APOH F3 F5 F8 FGA ITGA2B
2 cardiovascular system MP:0005385 9.95 F3 F5 FGA ITGA2B PLG SERPINC1
3 hematopoietic system MP:0005397 9.91 F3 F8 FGA ITGA2B PLG SERPINC1
4 immune system MP:0005387 9.86 F3 F8 FGA ITGA2B PLA2G7 PLG
5 mortality/aging MP:0010768 9.65 APOH F3 F5 F8 FGA MTHFR
6 liver/biliary system MP:0005370 9.55 F5 FGA MTHFR PLG SERPINC1
7 reproductive system MP:0005389 9.1 F8 FGA ITGA2B MTHFR PLG SERPINC1

Drugs & Therapeutics for Intracranial Thrombosis

Drugs for Intracranial Thrombosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved Phase 3 81-81-2 6691 54678486
2
Heparin Approved, Investigational Phase 2, Phase 3 9005-49-6 772 46507594
3
Dalteparin Approved Phase 2, Phase 3 9005-49-6
4
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
5
protease inhibitors Phase 3
6 Anticoagulants Phase 3,Phase 2
7 Antithrombin III Phase 3
8 HIV Protease Inhibitors Phase 3
9 Antithrombins Phase 3
10 Dabigatran Phase 3
11 Serine Proteinase Inhibitors Phase 3
12 Tissue Plasminogen Activator Phase 2, Phase 3
13 Calcium, Dietary Phase 2, Phase 3
14 calcium heparin Phase 2, Phase 3
15 Plasminogen Phase 2, Phase 3
16 Fibrinolytic Agents Phase 2, Phase 3
17 Heparin, Low-Molecular-Weight Phase 2, Phase 3
18
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
19
Levonorgestrel Approved, Investigational 17489-40-6, 797-63-7 13109
20
Ethinyl Estradiol Approved 57-63-6 5991
21 Estradiol valerate Approved, Investigational, Vet_approved 979-32-8
22
Polyestradiol phosphate Approved 28014-46-2
23 Estradiol 17 beta-cypionate
24 Hormones, Hormone Substitutes, and Hormone Antagonists
25 Ethinyl estradiol, levonorgestrel drug combination
26 Estradiol 3-benzoate
27 Contraceptive Agents
28 Norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination
29 Norinyl
30 Contraceptives, Oral
31 Hormone Antagonists
32 Estrogens
33 Hormones
34 Contraceptives, Oral, Combined

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Clinical Trial Comparing Efficacy and Safety of Dabigatran Etexilate With Warfarin in Patients With Cerebral Venous and Dural Sinus Thrombosis (RE-SPECT CVT) Completed NCT02913326 Phase 3 Dabigatran etexilate;Warfarin
2 Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis Terminated NCT01204333 Phase 2, Phase 3 Endovascular thrombolysis;Heparin
3 Prevention for the Restenosis of Intracranial Artery Stent Implantation Treated With Herbal Medicine C117 Not yet recruiting NCT03008798 Phase 2 Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
4 Modern Ultrasound Techniques in the Evaluation of Cerebral Venous Sinuses in Neonates Completed NCT00555932 Not Applicable
5 Study Of Lybrel In Relation To Venous Thromboembolism Completed NCT01297348 90ug levonorgestrel / 20 ug ethinyl estradiol;Oral Contraceptives containing 20 ug of ethinyl estradiol
6 Impact of Cranioplasty On Cerebral Perfusion Completed NCT01113645
7 Comparison of the Radiological Pattern Between the Cerebral Stroke of Arterial and Venous Origin Completed NCT03611894
8 Stroke and Cerebrovascular Diseases Registry Recruiting NCT03281590
9 Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment Scales Recruiting NCT03273179
10 Intracranial Thrombosis Aspiration Catheter for Recanalization in Acute Ischemic Stroke Therapy (RECOVER) Not yet recruiting NCT03753061 Not Applicable

Search NIH Clinical Center for Intracranial Thrombosis

Cochrane evidence based reviews: intracranial thrombosis

Genetic Tests for Intracranial Thrombosis

Anatomical Context for Intracranial Thrombosis

MalaCards organs/tissues related to Intracranial Thrombosis:

41
Heart, Lung, Spinal Cord, Placenta, Brain, Testes, Endothelial

Publications for Intracranial Thrombosis

Articles related to Intracranial Thrombosis:

(show top 50) (show all 154)
# Title Authors Year
1
Heterozygous FGA p.Asp473Ter (fibrinogen Nieuwegein) presenting as antepartum cerebral thrombosis. ( 29122299 )
2018
2
Effect of Melilotus officinalis extract on the apoptosis of brain tissues by altering cerebral thrombosis and inflammatory mediators in acute cerebral ischemia. ( 28320101 )
2017
3
Cerebral Thrombosis: A Neurogenetic Approach. ( 28971443 )
2017
4
Evaluation of cases with cerebral thrombosis in children. ( 27489465 )
2016
5
Acute Cerebral Thrombosis Following Ovarian Hyperstimulation Syndrome: A Case Report. ( 26668156 )
2015
6
Cerebral thrombosis and myeloproliferative neoplasms. ( 25217248 )
2014
7
Successful thrombolysis following enoxaparin therapy in two pediatric patients with congenital heart disease presenting with intracardiac and cerebral thrombosis. ( 25278813 )
2014
8
Incompletely Evaluated ART Leading to Ectopic Pregnancy and Cerebral Thrombosis. ( 24520477 )
2013
9
An 8-year follow-up of a patient with acute myocardial infarction complicated with ventricular rupture and cerebral thrombosis treated conservatively: a cohort study. ( 23531927 )
2013
10
Thrombolytic effects of a combined therapy with targeted microbubbles and ultrasound in a 6 h cerebral thrombosis rabbit model. ( 22016106 )
2012
11
Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive rats. ( 22228501 )
2012
12
Pulsatile tinnitus and venous cerebral thrombosis: report of a case and literature review. ( 23590107 )
2012
13
Cerebral thrombosis in inflammatory bowel disease: a report of four cases. ( 21575890 )
2011
14
Correspondence between neurological deficit, cerebral infarct size, and Rho-kinase activity in a rat cerebral thrombosis model. ( 19165632 )
2009
15
Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model. ( 18187127 )
2008
16
Cerebral thrombosis associated with heterozygous factor V Leiden mutation and high lipoprotein(a) level in a girl with factor XIII deficiency. ( 17473580 )
2007
17
Cerebral thrombosis in systemic lupus erythematosus with the antibody antiphospholipid syndrome. ( 17485792 )
2007
18
Carotid atherosclerosis and arterial peripheral pulse wave velocity in cerebral thrombosis. ( 16410196 )
2006
19
Extension of intracranial thrombosis after unilateral dissection of the internal jugular vein. ( 15897422 )
2005
20
Cerebral thrombosis in a postmenopausal woman on HRT. ( 15639431 )
2005
21
Protease nexin-2/amyloid beta-protein precursor limits cerebral thrombosis. ( 16330760 )
2005
22
Effects of the lifting manipulation of scalp acupuncture for raising myodynamia of the affected limbs in hemiplegic patients due to cerebral thrombosis. ( 16447664 )
2005
23
Effects of voluntary exercise on cerebral thrombosis and endothelial function in spontaneously hypertensive rats (SHRSP/Izm). ( 15649288 )
2004
24
Delayed-onset heparin-induced thrombocytopenia and cerebral thrombosis after a single administration of unfractionated heparin. ( 12637624 )
2003
25
Cerebral thrombosis and microcirculation of the rat during the oestrous cycle and after ovariectomy. ( 11906462 )
2002
26
Contraceptives and cerebral thrombosis: a five-year national case-control study. ( 11929641 )
2002
27
Effects of Ginkgo biloba extract (EGb 761) on cerebral thrombosis and blood pressure in stroke-prone spontaneously hypertensive rats. ( 12366386 )
2002
28
Clinical observation on influence of chinese medicines for promoting blood circulation to remove blood stasis on FIB and DD in plasma of patients with cerebral thrombosis. ( 16579084 )
2002
29
Cerebral thrombosis in beta-thalassaemia major. ( 11770248 )
2001
30
A case with cerebral thrombosis receiving tamoxifen treatment. ( 11784361 )
2001
31
The regional cerebral blood flow amelioration of argatroban in the acute stage of cerebral thrombosis. ( 10750366 )
2000
32
Cerebral thrombosis and vasculitis: an uncommon complication of ulcerative colitis. ( 10846281 )
2000
33
Neoplastic cerebral aneurysm from metastatic lung adenocarcinoma associated with cerebral thrombosis and recurrent subarachnoid haemorrhage. ( 10071112 )
1999
34
Cerebral thrombosis and oral contraceptives. A case-control study. ( 9673837 )
1998
35
Selective thrombolysis in a newborn with bilateral renal venous and cerebral thrombosis and heterozygous APC resistance. ( 9870492 )
1998
36
Hyperhomocysteinaemia in black patients with cerebral thrombosis. ( 9415345 )
1997
37
Effect of argatroban, a selective thrombin inhibitor, on animal models of cerebral thrombosis. ( 9469624 )
1997
38
Phenytoin-induced cerebral thrombosis in rats: cerebral ultrastructure, water content and ischaemic volume in the acute phase. ( 8977375 )
1996
39
Induction of cerebral thrombosis with phenytoin in rats. ( 7482654 )
1995
40
A simple and reproducible cerebral thrombosis model in rats induced by a photochemical reaction and the effect of a plasminogen-plasminogen activator chimera in this model. ( 8364230 )
1993
41
Review of thrombolytic use in acute myocardial infarction, pulmonary embolism, and cerebral thrombosis. ( 8431790 )
1993
42
Detection of In Vivo Activated Platelets in Experimental Cerebral Thrombosis: Studies Using a New Monoclonal Antibody 2T60, Specific for Activated Human and Rabbit Platelets. ( 21043851 )
1993
43
Participation of serum albumin and LDL-cholesterol in impaired blood cell-filterability affected by white blood cells in patients with cerebral thrombosis. ( 1455156 )
1992
44
Thromboxane-dependent platelet activation as a transducer of enhanced risk of coronary and cerebral thrombosis. ( 1825389 )
1991
45
Platelet volume, aggregation, and adenosine triphosphate release in cerebral thrombosis. ( 1987668 )
1991
46
Clinical effects and basic studies of thrombolytic therapy on cerebral thrombosis. ( 2122521 )
1990
47
Sneddon's syndrome (livedo reticularis and cerebral thrombosis) with livedo vasculitis and anticardiolipin antibodies. ( 2636849 )
1989
48
Effects of an antithrombotic agent (MD-805) on progressing cerebral thrombosis. ( 2655161 )
1989
49
Prognosis of elderly hospital patients with cerebral thrombosis. ( 3147811 )
1988
50
Cerebral thrombosis in a newborn with a congenital deficiency of antithrombin III. ( 3348205 )
1988

Variations for Intracranial Thrombosis

Expression for Intracranial Thrombosis

Search GEO for disease gene expression data for Intracranial Thrombosis.

Pathways for Intracranial Thrombosis

Pathways related to Intracranial Thrombosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.89 APOH F3 F5 F8 FGA ITGA2B
2
Show member pathways
12.44 F3 F5 F8 FGA SERPINC1
3
Show member pathways
11.96 FGA ITGA2B VWF
4
Show member pathways
11.81 FGA ITGA2B VWF
5
Show member pathways
11.74 FGA ITGA2B VWF
6
Show member pathways
11.7 F3 F5 F8 FGA PLG SERPINC1
7 11.67 FGA ITGA2B VWF
8
Show member pathways
11.54 FGA ITGA2B VWF
9 11.31 F3 F5 F8 FGA PLG SERPINC1
10 11.14 FGA ITGA2B VWF

GO Terms for Intracranial Thrombosis

Cellular components related to Intracranial Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.93 APOH FGA ITGA2B PLG SERPINC1 VWF
2 extracellular space GO:0005615 9.92 APOH F3 F5 F8 FGA PLA2G7
3 extracellular region GO:0005576 9.81 APOH F3 F5 F8 FGA PLA2G7
4 cell surface GO:0009986 9.8 APOH F3 FGA ITGA2B PLG
5 endoplasmic reticulum lumen GO:0005788 9.73 F5 F8 FGA SERPINC1
6 blood microparticle GO:0072562 9.67 FGA ITGA2B PLG SERPINC1
7 COPII-coated ER to Golgi transport vesicle GO:0030134 9.48 F5 F8
8 platelet alpha granule GO:0031091 9.43 F5 FGA VWF
9 collagen-containing extracellular matrix GO:0062023 9.43 APOH F3 FGA PLG SERPINC1 VWF
10 platelet alpha granule lumen GO:0031093 9.02 F5 F8 FGA PLG VWF

Biological processes related to Intracranial Thrombosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.7 F3 F5 F8 FGA PLG SERPINC1
2 extracellular matrix organization GO:0030198 9.67 FGA ITGA2B VWF
3 cellular protein metabolic process GO:0044267 9.62 F5 FGA PLG SERPINC1
4 platelet activation GO:0030168 9.61 F8 FGA VWF
5 platelet aggregation GO:0070527 9.52 FGA ITGA2B
6 blood circulation GO:0008015 9.51 F5 MTHFR
7 platelet degranulation GO:0002576 9.5 APOH F5 F8 FGA ITGA2B PLG
8 fibrinolysis GO:0042730 9.48 FGA PLG
9 regulation of blood coagulation GO:0030193 9.46 APOH SERPINC1
10 blood coagulation, intrinsic pathway GO:0007597 9.43 APOH F8 VWF
11 plasminogen activation GO:0031639 9.4 APOH FGA
12 negative regulation of fibrinolysis GO:0051918 9.37 APOH PLG
13 hemostasis GO:0007599 9.17 F3 F5 F8 FGA PLG SERPINC1

Molecular functions related to Intracranial Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.13 APOH F3 PLA2G7
2 protease binding GO:0002020 8.8 F3 SERPINC1 VWF

Sources for Intracranial Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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