MCID: INT078
MIFTS: 49

Intracranial Thrombosis

Categories: Blood diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Intracranial Thrombosis

MalaCards integrated aliases for Intracranial Thrombosis:

Name: Intracranial Thrombosis 12 43 15 71
Cerebral Thrombosis 12 74 54 71
Thrombosis of Cerebral Veins 71
Cerebral Arterial Thrombosis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4193
ICD9CM 34 434.0
MeSH 43 D020767
UMLS 71 C0079102 C0151945 C0752143 more

Summaries for Intracranial Thrombosis

MalaCards based summary : Intracranial Thrombosis, also known as cerebral thrombosis, is related to homocystinuria and hemophilia a. An important gene associated with Intracranial Thrombosis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Warfarin and Tenecteplase have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and endothelial, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 74 A thrombus, colloquially called a blood clot, is the final product of the blood coagulation step in... more...

Related Diseases for Intracranial Thrombosis

Diseases related to Intracranial Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 315)
# Related Disease Score Top Affiliating Genes
1 homocystinuria 30.2 SERPINC1 MTHFR F5
2 hemophilia a 30.0 VWF F8 F3
3 eclampsia 30.0 SERPINC1 MTHFR F2
4 hemoglobin e disease 30.0 F5 F2
5 mastoiditis 29.9 SERPINC1 MTHFR F2
6 acute cor pulmonale 29.8 PLG PLAT F3
7 heparin-induced thrombocytopenia 29.8 SERPINC1 F3 F10
8 sickle cell anemia 29.7 VWF MTHFR F2
9 papilledema 29.7 SERPINC1 F3 F2 APOH
10 protein c deficiency 29.7 SERPINC1 MTHFR F5 F2 APOH
11 cerebral sinovenous thrombosis 29.7 MTHFR F5 F3 F2 APOH
12 middle cerebral artery infarction 29.6 PLG PLAT
13 polycythemia vera 29.5 VWF SELP F5 F2
14 placental abruption 29.5 SERPINC1 MTHFR F5 F2 APOH
15 homocysteinemia 29.4 VWF SERPINC1 MTHFR F5 F2 APOH
16 hemoglobinuria 29.4 SERPINC1 SELP F2
17 dysfibrinogenemia, congenital 29.3 SERPINC1 PLAT FGA F5 F2
18 factor xiii deficiency 29.2 VWF SERPINC1 F8 F5 F3 F2
19 protein s deficiency 28.9 SERPINC1 MTHFR F8 F5 F3 F2
20 factor viii deficiency 28.8 VWF F8 F5 F3 F2 F10
21 coronary heart disease 1 28.8 VWF SELP PLAT PLA2G7 MTHFR
22 atherosclerosis susceptibility 28.8 VWF SELP PLAT PLA2G7 MTHFR F3
23 thrombophilia due to thrombin defect 28.7 SERPINC1 PLAT MTHFR F8 F5 F3
24 inflammatory bowel disease 28.7 SERPINC1 SELP MTHFR F5 F3 F2
25 thrombocytosis 28.7 VWF SERPINC1 SELP FGA F3 F2
26 intracranial embolism 28.6 WDTC1 SERPINC1 PLG PLAT F3 F2
27 essential thrombocythemia 28.2 VWF SERPINC1 SELP MTHFR ITGA2B F3
28 antithrombin iii deficiency 28.2 SERPINC1 PLG MTHFR FGA F5 F2
29 disseminated intravascular coagulation 27.8 VWF SERPINC1 PLG PLAT FGA F5
30 pulmonary embolism 27.6 VWF SERPINC1 PLAT MTHFR F8 F5
31 acute myocardial infarction 27.5 VWF SERPINC1 SELP PLG PLAT ITGA2B
32 antiphospholipid syndrome 27.5 VWF SERPINC1 SELP PLAT MTHFR F5
33 cerebrovascular disease 27.4 VWF SELP PLAT MTHFR ITGA2B FGA
34 thrombophlebitis 27.4 VWF SERPINC1 SELP PLG PLAT MTHFR
35 diabetes mellitus 27.3 VWF SERPINC1 SELP PLAT PLA2G7 MTHFR
36 thrombocytopenia 26.7 VWF SERPINC1 SELP PLAT ITGA2B FGA
37 thrombophilia 26.5 VWF SERPINC1 SELP PLG PLAT MTHFR
38 stroke, ischemic 26.4 VWF SERPINC1 SELP PLG PLAT PLA2G7
39 thrombosis 26.3 VWF SERPINC1 SELP PLG PLAT MTHFR
40 vascular disease 26.2 VWF SERPINC1 SELP PLG PLAT PLA2G7
41 carotid artery thrombosis 26.0 WDTC1 VWF SERPINC1 SELP PLG PLAT
42 glycosylphosphatidylinositol biosynthesis defect 1 11.2
43 may-thurner syndrome 10.5 F5 APOH
44 acanthamoeba keratitis 10.5 F5 APOH
45 sticky platelet syndrome 10.5 SERPINC1 F5
46 vulvar angiokeratoma 10.5 SERPINC1 F3
47 amaurosis fugax 10.5 MTHFR F5
48 fainting 10.5 VWF F8
49 meningococcemia 10.4 SERPINC1 F5
50 pediatric angiosarcoma 10.4 VWF F8

Comorbidity relations with Intracranial Thrombosis via Phenotypic Disease Network (PDN): (show all 19)


Active Peptic Ulcer Disease Acute Cystitis
Aortic Valve Disease 1 Benign Essential Hypertension
Cerebral Atherosclerosis Cerebrovascular Disease
Decubitus Ulcer Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intracranial Embolism Malignant Essential Hypertension
Peripheral Vascular Disease Schizophreniform Disorder
Spastic Hemiplegia Swallowing Disorders
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Intracranial Thrombosis:



Diseases related to Intracranial Thrombosis

Symptoms & Phenotypes for Intracranial Thrombosis

MGI Mouse Phenotypes related to Intracranial Thrombosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 APOH CIART F10 F2 F3 F5
2 cardiovascular system MP:0005385 10.17 F10 F2 F3 F5 FGA ITGA2B
3 hematopoietic system MP:0005397 10.1 F2 F3 F8 FGA ITGA2B PLAT
4 immune system MP:0005387 10.06 F2 F3 F8 FGA ITGA2B PLA2G7
5 mortality/aging MP:0010768 10.06 APOH CIART F10 F2 F3 F5
6 integument MP:0010771 9.86 F2 F3 F5 FGA MTHFR PLAT
7 nervous system MP:0003631 9.65 F2 F3 F5 FGA MTHFR PLAT
8 reproductive system MP:0005389 9.28 F10 F2 F8 FGA ITGA2B MTHFR

Drugs & Therapeutics for Intracranial Thrombosis

Drugs for Intracranial Thrombosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved Phase 3 81-81-2 6691 54678486
2
Tenecteplase Approved Phase 3 191588-94-0
3
Dalteparin Approved Phase 2, Phase 3 9005-49-6
4
Heparin Approved, Investigational Phase 2, Phase 3 9005-49-6 772 46507594
5
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
6
Dabigatran Investigational Phase 3 211914-51-1
7 HIV Protease Inhibitors Phase 3
8
protease inhibitors Phase 3
9 Serine Proteinase Inhibitors Phase 3
10 Antithrombin III Phase 3
11 Antithrombins Phase 3
12 Platelet Aggregation Inhibitors Phase 3
13 Protective Agents Phase 3
14 3-n-butylphthalide Phase 3
15 Neuroprotective Agents Phase 3
16 Plasminogen Inactivators Phase 3
17 Anticoagulants Phase 2, Phase 3
18 Fibrinolytic Agents Phase 2, Phase 3
19 Tissue Plasminogen Activator Phase 2, Phase 3
20 Plasminogen Phase 2, Phase 3
21 Calcium, Dietary Phase 2, Phase 3
22 Heparin, Low-Molecular-Weight Phase 2, Phase 3
23 calcium heparin Phase 2, Phase 3
24
Serine Investigational, Nutraceutical Phase 3 56-45-1 5951
25
Triamcinolone Approved, Vet_approved 124-94-7 31307
26
Polyestradiol phosphate Approved 28014-46-2
27
Ethinyl Estradiol Approved 57-63-6 5991
28
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
29
Levonorgestrel Approved, Investigational 17489-40-6, 797-63-7 13109
30 Triamcinolone diacetate
31 triamcinolone acetonide
32 Triamcinolone hexacetonide
33 Estrogens
34 Contraceptives, Oral
35 Ethinyl estradiol, levonorgestrel drug combination
36 Estradiol 17 beta-cypionate
37 Contraceptives, Oral, Combined
38 Norinyl
39 Estradiol 3-benzoate
40 Norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination
41 Hormone Antagonists
42 Contraceptive Agents
43 Hormones
44 Plasminogen Activator Inhibitor 1

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 RE-SPECT CVT: a Randomised, Open-label, Exploratory Trial With Blinded Endpoint Adjudication (PROBE), Comparing Efficacy and Safety of Oral Dabigatran Etexilate Versus Oral Warfarin in Patients With Cerebral Venous and Dural Sinus Thrombosis Over a 24-week Period Completed NCT02913326 Phase 3 Dabigatran etexilate;Warfarin
2 Butylphthalide for Preventing Restenosis After Intracranial and Extracranial Artery Stenting Completed NCT01405248 Phase 3 Butylphthalide;Placebo
3 Alteplase Compared to Tenecteplase in Patients With Acute Ischemic Stroke: QuICR & OPTIMISE Registry Based Pragmatic Randomized Controlled Trial Recruiting NCT03889249 Phase 3 Tenecteplase;Alteplase
4 Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis (TOACT) Terminated NCT01204333 Phase 2, Phase 3 Endovascular thrombolysis;Heparin
5 Randomized Controlled Clinical Study on Vulnerable Plaque of Carotid Artery With Chinese Herbal and Insects Medicine Unknown status NCT03072225 Phase 2 Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
6 Prevention for the Restenosis of Intracranial Artery Stent Implantation Treated With Herbal Medicine C117--PRISIT Trial Unknown status NCT03008798 Phase 2 Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
7 A Trial of Clay Weight on the Ear Drum for Patulous Eustachian Tube Unknown status NCT00933478
8 Utility of Modern Ultrasound Techniques in the Evaluation of Cerebral Venous Sinuses in Neonates Completed NCT00555932
9 Multimodal Monitoring in Patients With Spontaneous Intracerebral Hemorrhage Completed NCT02326571
10 Traumatic Intracranial Hemorrhage in Users of Oral Antithrombotic Drugs: a Nationwide Pharmacoepidemiological Study Completed NCT02996851
11 Postmarketing Study Of Lybrel In Relation To Venous Thromboembolism Completed NCT01297348 90ug levonorgestrel / 20 ug ethinyl estradiol;Oral Contraceptives containing 20 ug of ethinyl estradiol
12 Cyanotic Congenital Heart Disease: Prevalence of Pulmonary and Cerebral Thrombi-embolic Events Completed NCT02716402
13 Whole Body Hypothermia for the Treatment of Perinatal Asphyxial Encephalopathy Completed NCT00147030
14 Genetic Architecture of Plasma T-PA and PAI-1 Completed NCT00007410
15 The Impact of Cranioplasty on Local and Global Cerebral Blood Flow as Clinical Outcome Prognostic Factor in Patients Undergoing Decompressive Craniectomy for Severe Head Injury. Completed NCT01113645
16 The Safety and Efficacy of Intracranial Thrombosis Aspiration Catheter for Recanalization in Acute Ischemic Stroke Therapy- A Prospective, Multicenter, Open Label, Blinded, Randomized Controlled, Non-inferiority Study Recruiting NCT03753061
17 Stroke and Cerebrovascular Diseases Registry Recruiting NCT03281590
18 adaptatiVe Endovascular Strategy to the CloT MRI in Large Intracranial Vessel Occlusion Recruiting NCT04139486
19 Efficacy of Kinesio Taping on Pain, Pain Threshold and Emotional Status in Tension Type Headache Active, not recruiting NCT03665142
20 Cerebral Venous Thrombosis Cohort Study in China Mainland Not yet recruiting NCT03919305

Search NIH Clinical Center for Intracranial Thrombosis

Cochrane evidence based reviews: intracranial thrombosis

Genetic Tests for Intracranial Thrombosis

Anatomical Context for Intracranial Thrombosis

MalaCards organs/tissues related to Intracranial Thrombosis:

40
Brain, Heart, Endothelial, Testes, Lung, Whole Blood, Kidney

Publications for Intracranial Thrombosis

Articles related to Intracranial Thrombosis:

(show top 50) (show all 670)
# Title Authors PMID Year
1
Cerebral thrombosis associated with heterozygous factor V Leiden mutation and high lipoprotein(a) level in a girl with factor XIII deficiency. 54 61
17473580 2007
2
Significance of factor V, prothrombin, MTHFR, and PAI-1 genotypes in childhood cerebral thrombosis. 54 61
17456624 2007
3
[A 50-year history of new drugs in Japan-the development and trends of hemostatics and antithrombotic drugs]. 61 54
14570069 2003
4
Development of argatroban as an anticoagulant and antithrombin agent in Japan. 61 54
12811008 2002
5
[Neonatal cerebral thrombosis and deficit of factor V leiden]. 54 61
11003860 2000
6
Sustained activation of blood coagulation in patients with cerebral thrombosis. 61 54
7485075 1995
7
A case of cerebral infarction associated with positive antiphospholipid antibody in a systemic lupus patient. 61 54
8038146 1994
8
[Coagulation and fibrinolytic parameters in patients with various angiopathies--analysis in cerebral thrombosis, diabetic and vasculitic neuropathies]. 54 61
8403679 1993
9
Platelet-activating factor acetylhydrolase activity in red blood cell-stroma from patients with cerebral thrombosis. 61 54
1414232 1992
10
Platelet-activating factor acetylhydrolase in plasma lipoproteins from patients with ischemic stroke. 54 61
1636183 1992
11
Coagulation-fibrinolysis abnormalities in acute and chronic phases of cerebral thrombosis and embolism. 61 54
2148232 1990
12
Scutellarin inhibits hypoxia-induced epithelial-mesenchymal transition in bladder cancer cells. 61
31127618 2019
13
[Efficacy and safety of Shenxiong Glucose Injection in treatment of cerebral thrombosis:systematic review and Meta-analysis]. 61
31602832 2019
14
Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation. 61
31154815 2019
15
[Study on mechanism of Xixian Tongshuan Capsules based on network pharmacology]. 61
31342720 2019
16
Early diagnosis of cerebral thrombosis by EGFP-EGF1 protein conjugated ferroferric oxide magnetic nanoparticles. 61
30646803 2019
17
Antibiotic and Anticoagulation Therapy in Lemierre's Syndrome: Case Report and Review. 61
30773133 2019
18
Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy. 61
31662987 2019
19
Multicenter randomized trial of arsenic trioxide and Realgar-Indigo naturalis formula in pediatric patients with acute promyelocytic leukemia: Interim results of the SCCLG-APL clinical study. 61
30160789 2018
20
Association between urinary sodium excretion and coronary heart disease in hospitalized elderly patients in China. 61
29756493 2018
21
Stem Cell Factor in Combination with Granulocyte Colony-Stimulating Factor reduces Cerebral Capillary Thrombosis in a Mouse Model of CADASIL. 61
29871518 2018
22
Recent progress in the structural modification and pharmacological activities of ligustrazine derivatives. 61
29432947 2018
23
Heterozygous FGA p.Asp473Ter (fibrinogen Nieuwegein) presenting as antepartum cerebral thrombosis. 61
29122299 2018
24
Delayed cerebral thrombosis complicating pneumococcal meningitis: an autopsy study. 61
29427117 2018
25
Coexistent Ipsilateral Internal Carotid Artery Occlusion and Cerebral Venous Thrombosis in Hepatitis C. 61
29349091 2018
26
GPVI‑Fc‑PEG improves cerebral infarct volume and cerebral thrombosis in mouse model with cerebral thrombosis. 61
28944903 2017
27
Spinal epidural haematoma following thrombolysis for acute ischaemic stroke in patient within 48h of emergency lumbar microdiscectomy. 61
27549024 2017
28
A Case of Familial Hemophagocytic Lymphohistiocytosis Type 4 With Involvement of the Central Nervous System Complicated With Infarct. 61
28692549 2017
29
Mutation of the Kunitz-type proteinase inhibitor domain in the amyloid β-protein precursor abolishes its anti-thrombotic properties in vivo. 61
28499154 2017
30
A nested mechanistic sub-study into the effect of tranexamic acid versus placebo on intracranial haemorrhage and cerebral ischaemia in isolated traumatic brain injury: study protocol for a randomised controlled trial (CRASH-3 Trial Intracranial Bleeding Mechanistic Sub-Study [CRASH-3 IBMS]). 61
28716153 2017
31
Effect of Melilotus officinalis extract on the apoptosis of brain tissues by altering cerebral thrombosis and inflammatory mediators in acute cerebral ischemia. 61
28320101 2017
32
Microparticles from splenectomized β-thalassemia/HbE patients play roles on procoagulant activities with thrombotic potential. 61
27900452 2017
33
[Indicators of homeostasis, inflammation and homocysteine in ischemic stroke in the young age]. 61
29411742 2017
34
Cerebral Thrombosis: A Neurogenetic Approach. 61
28971443 2017
35
Correlation between secondary thrombosis in epileptic patients and serum levels of folate and vitamin B12. 61
27703674 2016
36
Binding of Breviscapine Toward Serum Albumin Studied by Spectroscopic and Electrochemical Techniques. 61
27080000 2016
37
A study on the PK and BA profiles in the mouse body for leonurine O/O microemulsion with determination by the LC-MS/MS method. 61
25698144 2016
38
Evaluation of cases with cerebral thrombosis in children. 61
27489465 2016
39
[The difficulties with the diagnosis of cerebral sinus thrombosis of a young woman - a case report]. 61
27234863 2016
40
The influence of the amyloid ß-protein and its precursor in modulating cerebral hemostasis. 61
26519139 2016
41
Centenarians' offspring as a model of healthy aging: a reappraisal of the data on Italian subjects and a comprehensive overview. 61
26979133 2016
42
Data on thrombotic ischemic lesions in the presence or absence of amyloid ß-protein precursor or its homolog amyloid precursor-like protein-2 in mice. 61
26858980 2016
43
Severe iron-deficiency anaemia and feeding practices in young children. 61
26027426 2016
44
Outcomes after acute ischemic stroke in patients with thrombocytopenia or thrombocytosis. 61
26944147 2016
45
[Thromboembolic complication after ovarian stimulation]. 61
26710204 2016
46
Vitamin D-Binding Protein Acts in the Actin Scavenge System and Can Have Increased Expression During Aspirin Therapy. 61
27149936 2016
47
Association between IL6 polymorphism and risk of cerebral infarction. 61
26662441 2015
48
Acute Cerebral Thrombosis Following Ovarian Hyperstimulation Syndrome: A Case Report. 61
26668156 2015
49
Genetic Ablation of Extra Domain A of Fibronectin in Hypercholesterolemic Mice Improves Stroke Outcome by Reducing Thrombo-Inflammation. 61
26508731 2015
50
Acute Central Nervous System Complications in Pediatric Acute Lymphoblastic Leukemia. 61
26202590 2015

Variations for Intracranial Thrombosis

Expression for Intracranial Thrombosis

Search GEO for disease gene expression data for Intracranial Thrombosis.

Pathways for Intracranial Thrombosis

Pathways related to Intracranial Thrombosis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 VWF SERPINC1 SELP PLG PLAT ITGA2B
2
Show member pathways
12.53 SERPINC1 FGA F8 F5 F3 F2
3
Show member pathways
12.11 PLG PLAT MTHFR F2
4
Show member pathways
11.86 VWF SERPINC1 PLG PLAT FGA F8
5
Show member pathways
11.8 PLG PLAT F2
6 11.8 VWF ITGA2B FGA F2
7
Show member pathways
11.66 VWF ITGA2B FGA F2
8 11.48 VWF SERPINC1 PLG PLAT FGA F8
9 11.33 VWF ITGA2B FGA F2
10 11.32 PLG PLAT FGA
11 11.29 SELP PLG PLAT
12 10.69 F2 F10
13 10.61 PLG PLAT

GO Terms for Intracranial Thrombosis

Cellular components related to Intracranial Thrombosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.08 VWF SERPINC1 PLG PLAT ITGA2B FGA
2 extracellular region GO:0005576 10.03 VWF SERPINC1 PLG PLAT PLA2G7 FGA
3 cell surface GO:0009986 9.93 PLG PLAT ITGA2B FGA F3 APOH
4 endoplasmic reticulum lumen GO:0005788 9.8 SERPINC1 FGA F8 F5 F2 F10
5 blood microparticle GO:0072562 9.77 SERPINC1 PLG ITGA2B FGA F2
6 extracellular space GO:0005615 9.73 SERPINC1 SELP PLG PLAT PLA2G7 FGA
7 platelet alpha granule GO:0031091 9.58 VWF FGA F5
8 platelet alpha granule lumen GO:0031093 9.55 VWF PLG FGA F8 F5
9 platelet alpha granule membrane GO:0031092 9.49 SELP ITGA2B
10 intrinsic component of external side of plasma membrane GO:0031233 9.43 F3 F10
11 collagen-containing extracellular matrix GO:0062023 9.23 VWF SERPINC1 PLG PLAT FGA F3

Biological processes related to Intracranial Thrombosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.86 WDTC1 SERPINC1 FGA F5
2 cellular protein metabolic process GO:0044267 9.85 SERPINC1 PLG FGA F5 F2
3 ER to Golgi vesicle-mediated transport GO:0006888 9.83 F8 F5 F2 F10
4 platelet activation GO:0030168 9.78 VWF FGA F8 F2
5 platelet degranulation GO:0002576 9.76 VWF SELP PLG ITGA2B FGA F8
6 fibrinolysis GO:0042730 9.62 PLG PLAT FGA F2
7 regulation of blood coagulation GO:0030193 9.61 SERPINC1 F2 APOH
8 hemostasis GO:0007599 9.61 VWF SERPINC1 PLG FGA F8 F5
9 plasminogen activation GO:0031639 9.58 PLAT FGA APOH
10 blood coagulation, intrinsic pathway GO:0007597 9.56 VWF F8 F2 APOH
11 positive regulation of blood coagulation GO:0030194 9.55 F2 APOH
12 positive regulation of leukocyte migration GO:0002687 9.54 SELP ITGA2B
13 negative regulation of fibrinolysis GO:0051918 9.54 PLG F2 APOH
14 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 9.51 PLG PLAT
15 blood coagulation, extrinsic pathway GO:0007598 9.49 F3 F10
16 blood coagulation GO:0007596 9.32 VWF SERPINC1 PLG PLAT FGA F8

Molecular functions related to Intracranial Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.22 WDTC1 VWF SERPINC1 SELP RHNO1 PLG
2 heparin binding GO:0008201 9.56 SERPINC1 SELP F2 APOH
3 protease binding GO:0002020 9.54 VWF SERPINC1 F3
4 serine-type peptidase activity GO:0008236 9.46 PLG PLAT F2 F10
5 phospholipid binding GO:0005543 9.26 PLA2G7 F3 F10 APOH
6 serine-type endopeptidase activity GO:0004252 9.02 PLG PLAT F3 F2 F10

Sources for Intracranial Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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