MCID: INT053
MIFTS: 32

Intracranial Vasospasm

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Intracranial Vasospasm

MalaCards integrated aliases for Intracranial Vasospasm:

Name: Intracranial Vasospasm 12 15 17
Vasospasm, Intracranial 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13100
MeSH 45 D020301
UMLS 74 C0751895

Summaries for Intracranial Vasospasm

MalaCards based summary : Intracranial Vasospasm, also known as vasospasm, intracranial, is related to stroke, ischemic and geniculate herpes zoster. An important gene associated with Intracranial Vasospasm is HP (Haptoglobin), and among its related pathways/superpathways are Binding and Uptake of Ligands by Scavenger Receptors and amb2 Integrin signaling. The drugs Milrinone and Verapamil have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and spinal cord, and related phenotype is hematopoietic system.

Related Diseases for Intracranial Vasospasm

Graphical network of the top 20 diseases related to Intracranial Vasospasm:



Diseases related to Intracranial Vasospasm

Symptoms & Phenotypes for Intracranial Vasospasm

MGI Mouse Phenotypes related to Intracranial Vasospasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.1 APOE FAM107B HP NOS3 PLAT TSPAN33

Drugs & Therapeutics for Intracranial Vasospasm

Drugs for Intracranial Vasospasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Milrinone Approved Phase 4,Phase 2 78415-72-2 4197
2
Verapamil Approved Phase 4 52-53-9 2520
3
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
4
Nicardipine Approved, Investigational Phase 4,Phase 2 55985-32-5 4474
5
Calcium Approved, Nutraceutical Phase 4,Phase 2,Phase 1 7440-70-2 271
6 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Not Applicable
7 Antimetabolites Phase 4,Not Applicable
8 Anticholesteremic Agents Phase 4,Not Applicable
9 Hypolipidemic Agents Phase 4,Not Applicable
10 Lipid Regulating Agents Phase 4,Not Applicable
11 Calcium, Dietary Phase 4,Phase 2,Phase 1
12 Hormones Phase 4,Phase 2
13 calcium channel blockers Phase 4,Phase 2
14 Vasodilator Agents Phase 4,Phase 2,Phase 1,Not Applicable
15 Eicosapentaenoic acid ethyl ester Phase 4
16 Omega 3 Fatty Acid Phase 4
17 Platelet Aggregation Inhibitors Phase 4,Phase 2
18 Antihypertensive Agents Phase 4,Phase 2
19 Anti-Arrhythmia Agents Phase 4
20 Anesthetics Phase 3,Phase 2,Phase 1,Not Applicable
21 Tin Fluorides Phase 3,Phase 2
22
Clevidipine Approved, Investigational Phase 2 167221-71-8
23
Dexmedetomidine Approved, Vet_approved Phase 2 113775-47-6 5311068 68602
24
tannic acid Approved Phase 2,Phase 1 1401-55-4
25
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
26
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
27
Benzocaine Approved, Investigational Phase 2,Phase 1 1994-09-7, 94-09-7 2337
28
Dantrolene Approved, Investigational Phase 1, Phase 2,Phase 2 7261-97-4 6914273 2952
29
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 6251 453
30
Bupivacaine Approved, Investigational Phase 2,Phase 1 38396-39-3, 2180-92-9 2474
31
Heparin Approved, Investigational Phase 2 9005-49-6 46507594 772
32
Sodium Citrate Approved, Investigational Phase 2,Phase 1 68-04-2
33
Clonidine Approved Phase 2 4205-90-7 2803
34
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2,Phase 1 77-92-9 311
35 Analgesics Phase 2,Not Applicable
36 Adrenergic Agonists Phase 2
37 GABA Modulators Phase 2
38 Central Nervous System Depressants Phase 2,Phase 1,Not Applicable
39 Peripheral Nervous System Agents Phase 2,Phase 1,Not Applicable
40 Adrenergic alpha-Agonists Phase 2
41 Neurotransmitter Agents Phase 2
42 Adrenergic alpha-2 Receptor Agonists Phase 2
43 Analgesics, Non-Narcotic Phase 2,Not Applicable
44
Glycopyrrolate Phase 2 596-51-0 3494
45 Anesthetics, Intravenous Phase 2
46 Analgesics, Opioid Phase 2
47 Adrenergic Agents Phase 2
48 Anti-Anxiety Agents Phase 2
49 Anesthetics, General Phase 2
50 Adjuvants, Anesthesia Phase 2

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 The Role of Statins in Preventing Cerebral Vasospasm Secondary to Subarachnoid Hemorrhage Unknown status NCT01346748 Phase 4 statin
2 Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study Completed NCT00839449 Phase 4 Eicosapentaenoic acid ethyl ester
3 The Intra-arterial Vasospasm Trial Recruiting NCT01996436 Phase 4 Nicardipine;Verapamil;Nicardipine + Verapamil + Nitroglycerin
4 EARLYdrain - Outcome After Early Lumbar CSF-drainage in Aneurysmal SAH Completed NCT01258257 Phase 3
5 The Tilburg Vasospasm Study Terminated NCT01407614 Phase 2, Phase 3
6 Clevidipine for Vasospasm After Subarachnoid Hemorrhage (SAH) Unknown status NCT02011321 Phase 2 clevidipine
7 Use of Dexmedetomidine in Acute Stroke and Cerebral Vasospasm Interventions Unknown status NCT01845441 Phase 2 Dexmedetomidine;Fentanyl;Midazolam
8 Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage: Unknown status NCT02432157 Phase 1, Phase 2 HTS 3%;Standard fluid management
9 Evaluation of the Efficacy and Safety of Clazosentan in Reversing Cerebral Vasospasm in Adult Subjects With Aneurysmal Subarachnoid Hemorrhage Completed NCT02560532 Phase 2 Clazosentan
10 Safety Study of Dantrolene in Subarachnoid Hemorrhage Completed NCT01024972 Phase 1, Phase 2 Dantrolene;Placebo
11 Safety Study of Dantrolene to Treat Cerebral Vasospasm After Subarachnoid Hemorrhage Completed NCT00964548 Phase 1, Phase 2 Dantrolene;Dantrolene
12 Clazosentan in Preventing the Occurrence of Cerebral Vasospasm Following an Aneurysmal Subarachnoid Hemorrhage (aSAH) Completed NCT00111085 Phase 2 Clazosentan 1 mg/h;Clazosentan 5 mg/h;Clazosentan 15 mg/h;Placebo
13 Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin Recruiting NCT02501434 Phase 2 Continuous Low-Dose IV Unfractionated Heparin Infusion
14 Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial Active, not recruiting NCT03318783 Phase 1, Phase 2 GSK2256294;Placebo
15 Safety Study of Nicardipine to Treat Cerebral Vasospasm Terminated NCT01810302 Phase 2 Nicardipine hydrochloride;Preservative-free normal saline
16 Milrinone in Addition to Hyperdynamic Therapy in the Treatment of Vasospasm Following Aneurysmal Subarachnoid Hemorrhage Terminated NCT02712788 Phase 2 Milrinone;Placebo
17 Intravenous Nitrite Infusion for Reversal of Cerebral Vasospasm After Subarachnoid Hemorrhage Terminated NCT02176837 Phase 2 Sodium Nitrite
18 Safety Study of Cervical Sympathetic Block for Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage Terminated NCT00930072 Phase 2 Cervical Sympathetic Block (bupivicaine, clonidine)
19 Safety Study of Sildenafil in Treatment of Cerebral Aneurysm Vasospasm Withdrawn NCT00871065 Phase 2 Sildenafil citrate
20 Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage Withdrawn NCT01878136 Phase 1, Phase 2 Tissue Plasminogen Activator
21 Sildenafil for Prevention of Cerebral Vasospasm Withdrawn NCT01091870 Phase 2 Placebo;Sildenafil Citrate, 25 mg, 3 times a day.;Sildenafil Citrate 50 mg, 3 times a day
22 Stellate Ganglion Block Using Ultrasound Guidance For Treatment Of Post Clipping Cerebral Vasospasm Completed NCT02775318 Phase 1 Bupivacaine
23 Cervical Spinal Cord Stimulation for the Prevention of Cerebral Vasospasm Completed NCT00766844 Phase 1
24 Remote Ischemic Preconditioning in Subarachnoid Hemorrhage Completed NCT01158508 Phase 1
25 Sildenafil for DCI Recruiting NCT03028298 Phase 1 Low dose sildenafil citrate;High dose sildenafil citrate
26 An Evaluation of Non-invasive Acoustic Approach to Detect and Monitor Cerebral Vasospasm Unknown status NCT02704637 Not Applicable
27 The Factors Cause Vasospasm After Aneurysmal Subarachnoid Hemorrhage Unknown status NCT00745758
28 An Evaluation of a Non-invasive Brain Monitor Unknown status NCT02775136 Not Applicable
29 Identification of Novel Molecular Markers for Vasospasm Unknown status NCT02389634
30 Safety Study of Carotid Body Neurostimulation to Treat Cerebral Vasospasm Unknown status NCT02129413 Not Applicable
31 Invasive Diagnostic and Therapeutic Management of Cerebral Vasospasm After Aneurysmatic Subarachnoid Hemorrhage Unknown status NCT01400360 Not Applicable
32 Perioperative Neuroprotection of Stellate Ganglion Block Unknown status NCT02275247 Not Applicable Stellate Ganglion Block
33 Non-Significant Risk Study Comparing the Nautilus NeuroWaveTM to Transcranial Doppler as an Aid to Diagnosing Vasospasm Completed NCT01595802 Not Applicable
34 Acupuncture for Cerebral Vasospasm After Subarachnoid Hemorrhage Completed NCT02275949 Not Applicable
35 Role of Proteomics and Metallomics in Cerebral Vasospasm Following Subarachnoid Hemorrhage Completed NCT01799018
36 Quality of Life in Elderly After Aneurysmal Subarachnoid Hemorrhage (SAH) Completed NCT00692744
37 Computed Tomographic (CT) Perfusion and CT Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage Completed NCT00962546
38 Role of CT Perfusion in Predicting Poor Outcome After Subarachnoid Hemorrhage Completed NCT03214705
39 Bilateral Bispectral Index (BIS) Study Completed NCT01187420
40 Lumenate Observational Vasospasm Interventional Trial (LOVIT) Recruiting NCT03511040 Not Applicable
41 Lumbar Drain vs Extraventricular Drain to Prevent Vasospasm in Subarachnoid Hemorrhage Recruiting NCT03065231 Not Applicable
42 Vesalio NeVa VS for Symptomatic Cerebral Vasospasm Following aSAH Recruiting NCT03611790 Not Applicable
43 Safety of Intravenous Milrinone for the Treatment of Subarachnoid Hemorrhage-induced Vasospasm Recruiting NCT03517670
44 Acetazolamide Challenge With Perfusion in the Prediction of Cerebral Vasospasm Recruiting NCT03377049
45 Contrast Enhanced Ultrasound Imaging for Cerebral Perfusion Measurement in Cerebral Vasospasm After SAH Recruiting NCT02907879
46 Evaluation of Transcutaneous Trigeminal Nerve Stimulation for Prevention of Cerebral Vasospasm After Subarachnoid Haemorrhage Active, not recruiting NCT02482883 Not Applicable
47 CT Perfusion Imaging to Predict Vasospasm in Subarachnoid Hemorrhage Active, not recruiting NCT02056769 Not Applicable
48 Acetaminophen in aSAH to Inhibit Lipid Peroxidation and Cerebral Vasospasm Enrolling by invitation NCT00585559 Not Applicable Placebos for acetaminophen and N-acetylcysteine;APAP 1 gm every 6 hours and N-acetylcysteine placebo;NAC IV infusion at 0.5 gm hourly and APAP placebo;APAP 1 gm q6 hours, plus NAC IV infusion at 0.5 gm hourly;APAP 1.5 gm q6 hours, plus NAC IV infusion at 0.5 gm hourly
49 Use of Brain Oxygen Tension Level and Cleaved-tau Protein to Detect Vasospasm After SAH Terminated NCT00582868
50 Use of Simvastatin for the Prevention of Vasospasm in Aneurysmal Subarachnoid Hemorrhage Terminated NCT00487461 Not Applicable Simvastatin 40 mg;Placebo;Simvastatin 80 mg

Search NIH Clinical Center for Intracranial Vasospasm

Cochrane evidence based reviews: vasospasm, intracranial

Genetic Tests for Intracranial Vasospasm

Anatomical Context for Intracranial Vasospasm

MalaCards organs/tissues related to Intracranial Vasospasm:

42
Brain, Heart, Spinal Cord

Publications for Intracranial Vasospasm

Articles related to Intracranial Vasospasm:

(show all 14)
# Title Authors Year
1
Use of stent retriever for treatment of iatrogenic intracranial vasospasm. ( 31088245 )
2019
2
Intracranial Vasospasm without Intracranial Hemorrhage due to Acute Spontaneous Spinal Subdural Hematoma. ( 26713084 )
2015
3
Treatment of intracranial vasospasm following subarachnoid hemorrhage. ( 24904517 )
2014
4
Intracranial vasospasm with delayed ischaemic deficit following epidermoid cyst resection. ( 20603397 )
2010
5
Intracranial vasospasm with subsequent stroke after traumatic subarachnoid hemorrhage in a 22-month-old child. ( 19338410 )
2009
6
Anesthetic considerations of selective intra-arterial nicardipine injection for intracranial vasospasm: a case series. ( 17413999 )
2007
7
Delayed intracranial vasospasm following carotid endarterectomy. ( 16088117 )
2005
8
Three-dimensional CT angiography of intracranial vasospasm following subarachnoid haemorrhage. ( 9833891 )
1998
9
Severe diffuse intracranial vasospasm as a cause of extensive migrainous cerebral infarction. ( 8374945 )
1993
10
Role of transcranial Doppler in neuroradiological treatment of intracranial vasospasm. ( 8421832 )
1993
11
Intraarterial papaverine for relief of catheter-induced intracranial vasospasm. ( 1546611 )
1992
12
Bilateral cervical carotid and intracranial vasospasm causing cerebral ischemia in a migrainous patient: a case of "diplegic migraine". ( 6490360 )
1984
13
Intracranial vasospasm: a study with iron compounds. ( 35848 )
1979
14
The relief of intracranial vasospasm: an experimental study with methylprednisolone and cortisol. ( 806982 )
1975

Variations for Intracranial Vasospasm

Expression for Intracranial Vasospasm

Search GEO for disease gene expression data for Intracranial Vasospasm.

Pathways for Intracranial Vasospasm

Pathways related to Intracranial Vasospasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.97 APOE HP
2 10.3 HP PLAT

GO Terms for Intracranial Vasospasm

Cellular components related to Intracranial Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle lumen GO:0071682 8.62 APOE HP

Biological processes related to Intracranial Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.26 APOE HP
2 vasodilation GO:0042311 9.16 APOE NOS3
3 nitric oxide mediated signal transduction GO:0007263 8.96 APOE NOS3
4 negative regulation of platelet activation GO:0010544 8.62 APOE NOS3

Molecular functions related to Intracranial Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antioxidant activity GO:0016209 8.62 APOE HP

Sources for Intracranial Vasospasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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