MCID: INT053
MIFTS: 33

Intracranial Vasospasm

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Intracranial Vasospasm

MalaCards integrated aliases for Intracranial Vasospasm:

Name: Intracranial Vasospasm 12 15
Vasospasm, Intracranial 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13100
MeSH 44 D020301
UMLS 73 C0751895

Summaries for Intracranial Vasospasm

MalaCards based summary : Intracranial Vasospasm, also known as vasospasm, intracranial, is related to stroke, ischemic and geniculate herpes zoster. An important gene associated with Intracranial Vasospasm is HP (Haptoglobin), and among its related pathways/superpathways are Fluid shear stress and atherosclerosis and Apelin signaling pathway. The drugs Milrinone and Nicardipine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and brain, and related phenotypes are hematopoietic system and immune system

Related Diseases for Intracranial Vasospasm

Diseases related to Intracranial Vasospasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 stroke, ischemic 27.4 APOE NOS3 PLAT TSPAN33
2 geniculate herpes zoster 10.3 HP KANTR
3 priapism 10.2 HP NOS3
4 dirofilariasis 10.2 HP PLAT
5 posterior myocardial infarction 10.2 KANTR PLAT
6 carotid artery thrombosis 10.2 NOS3 PLAT
7 premenstrual tension 10.2 HP KANTR
8 hellp syndrome 10.2 HP PLAT
9 toxic myocarditis 10.1 KANTR NOS3
10 carotid artery dissection 10.1 KANTR PLAT
11 alexia 10.0 APOE KANTR
12 hemorrhage, intracerebral 10.0 APOE PLAT
13 orthostatic intolerance 10.0 KANTR NOS3
14 ischemic heart disease 10.0 APOE NOS3
15 alzheimer disease 2 9.9 APOE NOS3
16 cerebritis 9.9
17 sleep apnea 9.8 APOE NOS3
18 basilar artery occlusion 9.8 PLAT TSPAN33
19 atherosclerosis susceptibility 9.8 APOE NOS3
20 subdural empyema 9.8 KANTR TSPAN33
21 central nervous system disease 9.7 APOE KANTR
22 epidermoid cysts 9.7
23 cervicitis 9.7
24 ischemia 9.7
25 hypertension, essential 9.7 HP NOS3 PLAT
26 nervous system disease 9.6 APOE KANTR
27 cerebrovascular disease 9.5 APOE PLAT
28 speech and communication disorders 9.5 APOE KANTR PLAT
29 myocardial infarction 9.3 APOE NOS3 PLAT
30 hypercholesterolemia, familial 9.2 APOE NOS3
31 diabetes mellitus, noninsulin-dependent 9.1 APOE NOS3 PLAT
32 vascular disease 9.0 APOE HP NOS3 PLAT
33 coronary artery anomaly 9.0 APOE HP NOS3 PLAT
34 arteries, anomalies of 8.9 APOE KANTR NOS3 PLAT

Graphical network of the top 20 diseases related to Intracranial Vasospasm:



Diseases related to Intracranial Vasospasm

Symptoms & Phenotypes for Intracranial Vasospasm

MGI Mouse Phenotypes related to Intracranial Vasospasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.35 APOE HP NOS3 PLAT TSPAN33
2 immune system MP:0005387 9.02 APOE HP NOS3 PLAT TSPAN33

Drugs & Therapeutics for Intracranial Vasospasm

Drugs for Intracranial Vasospasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Milrinone Approved Phase 4,Phase 2 78415-72-2 4197
2
Nicardipine Approved, Investigational Phase 4,Phase 2 55985-32-5 4474
3
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
4
Verapamil Approved Phase 4 52-53-9 2520
5 Anticholesteremic Agents Phase 4,Not Applicable
6 Antimetabolites Phase 4,Not Applicable
7 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Not Applicable
8 Hypolipidemic Agents Phase 4,Not Applicable
9 Lipid Regulating Agents Phase 4,Not Applicable
10 calcium channel blockers Phase 4,Phase 2
11 Calcium, Dietary Phase 4,Phase 2,Phase 1
12 Vasodilator Agents Phase 4,Phase 2,Phase 1,Not Applicable
13 Eicosapentaenoic acid ethyl ester Phase 4
14 Platelet Aggregation Inhibitors Phase 4,Phase 2
15 Anti-Arrhythmia Agents Phase 4
16 Antihypertensive Agents Phase 4,Phase 2
17 Omega 3 Fatty Acid Nutraceutical Phase 4
18 Anesthetics Phase 3,Phase 2,Phase 1,Not Applicable
19 Tin Fluorides Phase 3,Phase 2
20
Clevidipine Approved, Investigational Phase 2 167221-71-8
21
Benzocaine Approved, Investigational Phase 2,Phase 1 1994-09-7, 94-09-7 2337
22
Dexmedetomidine Approved, Vet_approved Phase 2 113775-47-6 68602 5311068
23
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
24
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
25
Dantrolene Approved, Investigational Phase 1, Phase 2,Phase 2 7261-97-4 2952 6914273
26
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 453 6251
27
Bupivacaine Approved, Investigational Phase 2,Phase 1 2180-92-9, 38396-39-3 2474
28
Heparin Approved, Investigational Phase 2 9005-49-6 772 46507594
29
Clonidine Approved Phase 2 4205-90-7 2803
30 tannic acid Approved, Nutraceutical Phase 2,Phase 1
31
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2,Phase 1 77-92-9 311
32 Adjuvants, Anesthesia Phase 2
33 Adrenergic Agents Phase 2
34 Adrenergic Agonists Phase 2
35 Adrenergic alpha-2 Receptor Agonists Phase 2
36 Adrenergic alpha-Agonists Phase 2
37 Analgesics Phase 2,Not Applicable
38 Analgesics, Non-Narcotic Phase 2,Not Applicable
39 Analgesics, Opioid Phase 2
40 Anesthetics, General Phase 2
41 Anesthetics, Intravenous Phase 2
42 Anti-Anxiety Agents Phase 2
43 Central Nervous System Depressants Phase 2,Phase 1,Not Applicable
44 GABA Agents Phase 2
45 GABA Modulators Phase 2
46
Glycopyrrolate Phase 2 596-51-0 3494
47 Hypnotics and Sedatives Phase 2
48 Narcotics Phase 2
49 Neurotransmitter Agents Phase 2
50 Peripheral Nervous System Agents Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 The Role of Statins in Preventing Cerebral Vasospasm Secondary to Subarachnoid Hemorrhage Unknown status NCT01346748 Phase 4 statin
2 Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study Completed NCT00839449 Phase 4 Eicosapentaenoic acid ethyl ester
3 The Intra-arterial Vasospasm Trial Recruiting NCT01996436 Phase 4 Nicardipine;Verapamil;Nicardipine + Verapamil + Nitroglycerin
4 EARLYdrain - Outcome After Early Lumbar CSF-drainage in Aneurysmal SAH Completed NCT01258257 Phase 3
5 The Tilburg Vasospasm Study Terminated NCT01407614 Phase 2, Phase 3
6 Clevidipine for Vasospasm After Subarachnoid Hemorrhage (SAH) Unknown status NCT02011321 Phase 2 clevidipine
7 Use of Dexmedetomidine in Acute Stroke and Cerebral Vasospasm Interventions Unknown status NCT01845441 Phase 2 Dexmedetomidine;Fentanyl;Midazolam
8 Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage: Unknown status NCT02432157 Phase 1, Phase 2 HTS 3%;Standard fluid management
9 Evaluation of the Efficacy and Safety of Clazosentan in Reversing Cerebral Vasospasm in Adult Subjects With Aneurysmal Subarachnoid Hemorrhage Completed NCT02560532 Phase 2 Clazosentan
10 Safety Study of Dantrolene in Subarachnoid Hemorrhage Completed NCT01024972 Phase 1, Phase 2 Dantrolene;Placebo
11 Safety Study of Dantrolene to Treat Cerebral Vasospasm After Subarachnoid Hemorrhage Completed NCT00964548 Phase 1, Phase 2 Dantrolene;Dantrolene
12 Clazosentan in Preventing the Occurrence of Cerebral Vasospasm Following an Aneurysmal Subarachnoid Hemorrhage (aSAH) Completed NCT00111085 Phase 2 Clazosentan 1 mg/h;Clazosentan 5 mg/h;Clazosentan 15 mg/h;Placebo
13 Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin Recruiting NCT02501434 Phase 2 Continuous Low-Dose IV Unfractionated Heparin Infusion
14 Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial Recruiting NCT03318783 Phase 1, Phase 2 GSK2256294;Placebo
15 Safety Study of Nicardipine to Treat Cerebral Vasospasm Terminated NCT01810302 Phase 2 Nicardipine hydrochloride;Preservative-free normal saline
16 Milrinone in Addition to Hyperdynamic Therapy in the Treatment of Vasospasm Following Aneurysmal Subarachnoid Hemorrhage Terminated NCT02712788 Phase 2 Milrinone;Placebo
17 Intravenous Nitrite Infusion for Reversal of Cerebral Vasospasm After Subarachnoid Hemorrhage Terminated NCT02176837 Phase 2 Sodium Nitrite
18 Safety Study of Cervical Sympathetic Block for Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage Terminated NCT00930072 Phase 2 Cervical Sympathetic Block (bupivicaine, clonidine)
19 Safety Study of Sildenafil in Treatment of Cerebral Aneurysm Vasospasm Withdrawn NCT00871065 Phase 2 Sildenafil citrate
20 Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage Withdrawn NCT01878136 Phase 1, Phase 2 Tissue Plasminogen Activator
21 Sildenafil for Prevention of Cerebral Vasospasm Withdrawn NCT01091870 Phase 2 Placebo;Sildenafil Citrate, 25 mg, 3 times a day.;Sildenafil Citrate 50 mg, 3 times a day
22 Stellate Ganglion Block Using Ultrasound Guidance For Treatment Of Post Clipping Cerebral Vasospasm Completed NCT02775318 Phase 1 Bupivacaine
23 Cervical Spinal Cord Stimulation for the Prevention of Cerebral Vasospasm Completed NCT00766844 Phase 1
24 Remote Ischemic Preconditioning in Subarachnoid Hemorrhage Completed NCT01158508 Phase 1
25 Sildenafil for DCI Recruiting NCT03028298 Phase 1 Low dose sildenafil citrate;High dose sildenafil citrate
26 The Factors Cause Vasospasm After Aneurysmal Subarachnoid Hemorrhage Unknown status NCT00745758
27 Safety Study of Carotid Body Neurostimulation to Treat Cerebral Vasospasm Unknown status NCT02129413 Not Applicable
28 Invasive Diagnostic and Therapeutic Management of Cerebral Vasospasm After Aneurysmatic Subarachnoid Hemorrhage Unknown status NCT01400360 Not Applicable
29 Perioperative Neuroprotection of Stellate Ganglion Block Unknown status NCT02275247 Not Applicable Stellate Ganglion Block
30 Non-Significant Risk Study Comparing the Nautilus NeuroWaveTM to Transcranial Doppler as an Aid to Diagnosing Vasospasm Completed NCT01595802 Not Applicable
31 Acupuncture for Cerebral Vasospasm After Subarachnoid Hemorrhage Completed NCT02275949 Not Applicable
32 Role of Proteomics and Metallomics in Cerebral Vasospasm Following Subarachnoid Hemorrhage Completed NCT01799018
33 Quality of Life in Elderly After Aneurysmal Subarachnoid Hemorrhage (SAH) Completed NCT00692744
34 Computed Tomographic (CT) Perfusion and CT Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage Completed NCT00962546
35 Bilateral Bispectral Index (BIS) Study Completed NCT01187420
36 Lumenate Observational Vasospasm Interventional Trial (LOVIT) Recruiting NCT03511040 Not Applicable
37 Lumbar Drain vs Extraventricular Drain to Prevent Vasospasm in Subarachnoid Hemorrhage Recruiting NCT03065231 Not Applicable
38 An Evaluation of a Non-invasive Brain Monitor Recruiting NCT02775136 Not Applicable
39 Contrast Enhanced Ultrasound Imaging for Cerebral Perfusion Measurement in Cerebral Vasospasm After SAH Recruiting NCT02907879
40 Evaluation of Transcutaneous Trigeminal Nerve Stimulation for Prevention of Cerebral Vasospasm After Subarachnoid Haemorrhage Recruiting NCT02482883 Not Applicable
41 Role of CT Perfusion in Predicting Poor Outcome After Subarachnoid Hemorrhage Recruiting NCT03214705
42 CT Perfusion Imaging to Predict Vasospasm in Subarachnoid Hemorrhage Recruiting NCT02056769 Not Applicable
43 Identification of Novel Molecular Markers for Vasospasm Active, not recruiting NCT02389634
44 Acetaminophen in aSAH to Inhibit Lipid Peroxidation and Cerebral Vasospasm Enrolling by invitation NCT00585559 Not Applicable Placebos for acetaminophen and N-acetylcysteine;APAP 1 gm every 6 hours and N-acetylcysteine placebo;NAC IV infusion at 0.5 gm hourly and APAP placebo;APAP 1 gm q6 hours, plus NAC IV infusion at 0.5 gm hourly;APAP 1.5 gm q6 hours, plus NAC IV infusion at 0.5 gm hourly
45 An Evaluation of Non-invasive Acoustic Approach to Detect and Monitor Cerebral Vasospasm Not yet recruiting NCT02704637 Not Applicable
46 Safety of Intravenous Milrinone for the Treatment of Subarachnoid Hemorrhage-induced Vasospasm Not yet recruiting NCT03517670
47 Acetazolamide Challenge With Perfusion in the Prediction of Cerebral Vasospasm Not yet recruiting NCT03377049
48 Use of Brain Oxygen Tension Level and Cleaved-tau Protein to Detect Vasospasm After SAH Terminated NCT00582868
49 Use of Simvastatin for the Prevention of Vasospasm in Aneurysmal Subarachnoid Hemorrhage Terminated NCT00487461 Not Applicable Simvastatin 40 mg;Placebo;Simvastatin 80 mg
50 Continuous Neurophysiological Monitoring Detection of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage Subjects Terminated NCT01343537 Early Phase 1

Search NIH Clinical Center for Intracranial Vasospasm

Cochrane evidence based reviews: vasospasm, intracranial

Genetic Tests for Intracranial Vasospasm

Anatomical Context for Intracranial Vasospasm

MalaCards organs/tissues related to Intracranial Vasospasm:

41
Spinal Cord, Brain

Publications for Intracranial Vasospasm

Articles related to Intracranial Vasospasm:

(show all 13)
# Title Authors Year
1
Intracranial Vasospasm without Intracranial Hemorrhage due to Acute Spontaneous Spinal Subdural Hematoma. ( 26713084 )
2015
2
Treatment of intracranial vasospasm following subarachnoid hemorrhage. ( 24904517 )
2014
3
Intracranial vasospasm with delayed ischaemic deficit following epidermoid cyst resection. ( 20603397 )
2010
4
Intracranial vasospasm with subsequent stroke after traumatic subarachnoid hemorrhage in a 22-month-old child. ( 19338410 )
2009
5
Anesthetic considerations of selective intra-arterial nicardipine injection for intracranial vasospasm: a case series. ( 17413999 )
2007
6
Delayed intracranial vasospasm following carotid endarterectomy. ( 16088117 )
2005
7
Three-dimensional CT angiography of intracranial vasospasm following subarachnoid haemorrhage. ( 9833891 )
1998
8
Severe diffuse intracranial vasospasm as a cause of extensive migrainous cerebral infarction. ( 8374945 )
1993
9
Role of transcranial Doppler in neuroradiological treatment of intracranial vasospasm. ( 8421832 )
1993
10
Intraarterial papaverine for relief of catheter-induced intracranial vasospasm. ( 1546611 )
1992
11
Bilateral cervical carotid and intracranial vasospasm causing cerebral ischemia in a migrainous patient: a case of "diplegic migraine". ( 6490360 )
1984
12
Intracranial vasospasm: a study with iron compounds. ( 35848 )
1979
13
The relief of intracranial vasospasm: an experimental study with methylprednisolone and cortisol. ( 806982 )
1975

Variations for Intracranial Vasospasm

Expression for Intracranial Vasospasm

Search GEO for disease gene expression data for Intracranial Vasospasm.

Pathways for Intracranial Vasospasm

Pathways related to Intracranial Vasospasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 NOS3 PLAT
2 11.29 NOS3 PLAT
3
Show member pathways
10.97 APOE HP
4 10.3 HP PLAT

GO Terms for Intracranial Vasospasm

Cellular components related to Intracranial Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle lumen GO:0071682 8.62 APOE HP

Biological processes related to Intracranial Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.26 APOE HP
2 vasodilation GO:0042311 9.16 APOE NOS3
3 nitric oxide mediated signal transduction GO:0007263 8.96 APOE NOS3
4 negative regulation of platelet activation GO:0010544 8.62 APOE NOS3

Molecular functions related to Intracranial Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antioxidant activity GO:0016209 8.62 APOE HP

Sources for Intracranial Vasospasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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