MCID: INT053
MIFTS: 24

Intracranial Vasospasm

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Intracranial Vasospasm

MalaCards integrated aliases for Intracranial Vasospasm:

Name: Intracranial Vasospasm 12 15 17
Vasospasm, Intracranial 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13100
MeSH 43 D020301
UMLS 71 C0751895

Summaries for Intracranial Vasospasm

MalaCards based summary : Intracranial Vasospasm, also known as vasospasm, intracranial, is related to migraine with or without aura 1 and epidermoid cysts. An important gene associated with Intracranial Vasospasm is TSPAN33 (Tetraspanin 33). The drugs Nicardipine and Milrinone have been mentioned in the context of this disorder. Affiliated tissues include brain and spinal cord.

Related Diseases for Intracranial Vasospasm

Diseases related to Intracranial Vasospasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 10.0
2 epidermoid cysts 9.9
3 hydrocephalus, congenital, 1 9.9
4 yemenite deaf-blind hypopigmentation syndrome 9.9
5 migraine with aura 9.9
6 intracranial aneurysm 9.9
7 cortical blindness 9.9
8 craniosynostosis 9.9
9 vasculitis 9.9
10 aneurysm 9.9
11 cerebral aneurysms 9.9
12 headache 9.9
13 patent foramen ovale 9.5 FAM107B ECI1
14 cerebral arterial disease 9.4 TSPAN33 S100B ECI1
15 intracranial berry aneurysm 9.0 SLC25A15 S100B ECI1

Graphical network of the top 20 diseases related to Intracranial Vasospasm:



Diseases related to Intracranial Vasospasm

Symptoms & Phenotypes for Intracranial Vasospasm

Drugs & Therapeutics for Intracranial Vasospasm

Drugs for Intracranial Vasospasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicardipine Approved, Investigational Phase 4 55985-32-5 4474
2
Milrinone Approved Phase 4 78415-72-2 4197
3
Verapamil Approved Phase 4 52-53-9 2520
4
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
5 Eicosapentaenoic acid ethyl ester Phase 4
6 Omega 3 Fatty Acid Phase 4
7 Antihypertensive Agents Phase 4
8 Hormones Phase 4
9 Calcium, Dietary Phase 4
10 calcium channel blockers Phase 4
11 Anti-Arrhythmia Agents Phase 4
12
Calcium Nutraceutical Phase 4 7440-70-2 271
13 Anesthetics Phase 3
14 Tin Fluorides Phase 3
15
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
16
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
17
Dexmedetomidine Approved, Vet_approved Phase 2 113775-47-6 5311068 68602
18
tannic acid Approved Phase 2 1401-55-4
19
Benzocaine Approved, Investigational Phase 2 94-09-7, 1994-09-7 2337
20
Clevidipine Approved, Investigational Phase 2 167221-71-8
21
Dantrolene Approved, Investigational Phase 1, Phase 2 7261-97-4 6914273 2952
22
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 6251 453
23
Heparin Approved, Investigational Phase 2 9005-49-6 46507594 772
24
Clonidine Approved Phase 2 4205-90-7 2803
25
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
26 Narcotics Phase 2
27 Anti-Anxiety Agents Phase 2
28 Anesthetics, General Phase 2
29 Analgesics, Opioid Phase 2
30 Psychotropic Drugs Phase 2
31 GABA Modulators Phase 2
32 Hypnotics and Sedatives Phase 2
33 Anesthetics, Intravenous Phase 2
34
Glycopyrrolate Phase 2 596-51-0 3494
35 diuretics Phase 1, Phase 2
36 calcium heparin Phase 2
37 Neurotransmitter Agents Phase 2
38 Adrenergic alpha-Agonists Phase 2
39 Adrenergic Agents Phase 2
40 Pharmaceutical Solutions Phase 2
41 Sympatholytics Phase 2
42 Anesthetics, Local Phase 2
43 Analgesics Phase 2
44 Adrenergic Agonists Phase 2
45 Cardiotonic Agents Phase 2
46 Phosphodiesterase 3 Inhibitors Phase 2
47 Protective Agents Phase 2
48
Vitamin A Approved, Nutraceutical, Vet_approved Phase 1 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
49 retinol Phase 1
50 Retinol palmitate Phase 1

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 The Role of Statins in Preventing Cerebral Vasospasm Secondary to Subarachnoid Hemorrhage Unknown status NCT01346748 Phase 4 statin
2 Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study (EVAS): Effect of Eicosapentaenoic Acid on Cerebral Vasospasm Following Subarachnoid Hemorrhage Completed NCT00839449 Phase 4 Eicosapentaenoic acid ethyl ester
3 The Intra-arterial Vasospasm Trial(iVAST)- A Multi-center Randomized Study Recruiting NCT01996436 Phase 4 Nicardipine;Verapamil;Nicardipine + Verapamil + Nitroglycerin
4 EARLYdrain - Prospective Outcome Study of Early Lumbar Drainage in Aneurysmal Subarachnoid Hemorrhage Completed NCT01258257 Phase 3
5 Aneurysmal Subarachnoid Hemorrhage - Red Blood Cell Transfusion and Outcome (SAHaRA): A Randomized Controlled Trial Recruiting NCT03309579 Phase 3
6 Prevention of Secondary Ischemia After Aneurysmal Subarachnoid Hemorrhage With Cerebrospinal Fluid Drainage. A Randomized Controlled Trial Terminated NCT01407614 Phase 2, Phase 3
7 A Randomized, Controlled Trial on Dexmedetomidine for Providing Adequate Sedation and Preserved Neurologic Examination for Endovascular Treatment of Acute Ischemic Stroke or Cerebral Vasospasm. Unknown status NCT01845441 Phase 2 Dexmedetomidine;Fentanyl;Midazolam
8 Hypertonic Saline Solution in Aneurysmal Subarachnoid Hemorrhage: A Randomized - Phase II Single Blinded Clinical Trial Unknown status NCT02432157 Phase 1, Phase 2 HTS 3%;Standard fluid management
9 Clevidipine for Vasospasm After Subarachnoid Hemorrhage Unknown status NCT02011321 Phase 2 clevidipine
10 A Phase IIb, Multi-center, International, Double-blind, Randomized, Placebo-controlled, Parallel-group, Dose-finding Study for the Prevention of Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage (aSAH) by Intravenous Administration of Clazosentan, a Selective Endothelin A (ETA) Receptor Antagonist Completed NCT00111085 Phase 2 Clazosentan 1 mg/h;Clazosentan 5 mg/h;Clazosentan 15 mg/h;Placebo
11 A Prospective, Multi-center, Open-label, Single-arm, Phase 2 Study to Assess the Efficacy and Safety of Clazosentan in Reversing Angiographically-confirmed Cerebral Vasospasm in Adult Subjects With Aneurysmal Subarachnoid Hemorrhage (aSAH) Treated by Surgical Clipping or Endovascular Coiling Completed NCT02560532 Phase 2 Clazosentan
12 Dantrolene in the Treatment of Cerebral Vasospasm After Subarachnoid Hemorrhage - a Phase 1 Study Completed NCT00964548 Phase 1, Phase 2 Dantrolene;Dantrolene
13 Dantrolene in the Prevention and Treatment of Cerebral Vasospasm in Subarachnoid Hemorrhage Completed NCT01024972 Phase 1, Phase 2 Dantrolene;Placebo
14 A Blind-adjudication Multi-center Phase II Randomized Clinical Trial of Continuous Low-dose Intravenous Heparin Therapy in Coiled Low-grade Aneurysmal Subarachnoid Hemorrhage Patients With Significant Hemorrhage Burden Recruiting NCT02501434 Phase 2 Continuous Low-Dose IV Unfractionated Heparin Infusion
15 Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial Active, not recruiting NCT03318783 Phase 1, Phase 2 GSK2256294;Placebo
16 Intraventricular Nicardipine for the Treatment of Cerebral Vasospasm: Prospective Pilot Study Terminated NCT01810302 Phase 2 Nicardipine hydrochloride;Preservative-free normal saline
17 Safety and Efficacy of Cervical Sympathetic Block in Patients With Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage - Pilot Study Terminated NCT00930072 Phase 2 Cervical Sympathetic Block (bupivicaine, clonidine)
18 Milrinone in Addition to Hyperdynamic Therapy in the Treatment of Vasospasm Following Aneurysmal Subarachnoid Hemorrhage Terminated NCT02712788 Phase 2 Milrinone;Placebo
19 Evaluation of Intravenous Nitrite Infusion for Reversal of Cerebral Vasospasm After Subarachnoid Hemorrhage From a Cerebral Aneurysm Terminated NCT02176837 Phase 2 Sodium Nitrite
20 Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage Withdrawn NCT01878136 Phase 1, Phase 2 Tissue Plasminogen Activator
21 Sildenafil for Prevention of Cerebral Vasospasm Secondary to Subarachnoid Haemorrhage - Phase II Randomized Clinical Trial Withdrawn NCT01091870 Phase 2 Placebo;Sildenafil Citrate, 25 mg, 3 times a day.;Sildenafil Citrate 50 mg, 3 times a day
22 Safety and Efficacy Trial of Sildenafil Citrate in Attenuation of Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage Withdrawn NCT00871065 Phase 2 Sildenafil citrate
23 Cervical Spinal Cord Stimulation for the Prevention of Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage Using MTS Trial System 3510 Completed NCT00766844 Phase 1
24 Prophylactic Remote Ischemic Preconditioning for Cerebral Vasospasm Following Subarachnoid Hemorrhage Completed NCT01158508 Phase 1
25 Efficacy Of Ultrasound Guided Stellate Ganglion Block To Relieve Vasospasm Following Clipping Of Cerebral Aneurysm Completed NCT02775318 Phase 1 Bupivacaine
26 Sildenafil for the Treatment of Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage Active, not recruiting NCT03028298 Phase 1 Low dose sildenafil citrate;High dose sildenafil citrate
27 Lumenate Observational Vasospasm Interventional Trial (LOVIT) Unknown status NCT03511040
28 Invasive Diagnostic and Therapeutic Management of Cerebral Vasospasm After Aneurysmatic Subarachnoid Hemorrhage Unknown status NCT01400360
29 The Factors Cause Vasospasm After Aneurysmal Subarachnoid Hemorrhage Unknown status NCT00745758
30 An Open-Label, Non-Randomized, Comparative Study Designed to Evaluate the Accuracy and Safety of HS-1000 Device, a Non-Invasive Brain Monitor Unknown status NCT02775136
31 An Evaluation of Non-invasive Acoustic Approach to Detect and Monitor Cerebral Vasospasm Unknown status NCT02704637
32 Safety and Performance of the Delta System in the Treatment of Vasospasm in Aneurysmal Subarachnoid Hemorrhage (aSAH) Patients Unknown status NCT02129413
33 Role of Proteomics and Metallomics in Cerebral Vasospasm Following Subarachnoid Hemorrhage Completed NCT01799018
34 Clinical Implication of Prolonged Vasospasm in Subarachnoid Hemorrhage Completed NCT04193124
35 Computed Tomographic Perfusion and Computed Tomographic Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage Completed NCT00962546
36 Role of Computed Tomography Perfusion in Detection of Patients at Risk for Delayed Cerebral Ischemia After Subarachnoid Hemorrhage Completed NCT03214705
37 Real Time Monitoring for Cerebral Vasospasm Using Bilateral Processed Electroencephalogram (EEG) Completed NCT01187420
38 Study of Quality of Life After Aneurysmal Subarachnoid Hemorrhage in Patients Aged 70 Years or Older. Completed NCT00692744
39 The Efficacy and Safety of Acupuncture for Cerebral Vasospasm After Subarachnoid Hemorrhage Completed NCT02275949
40 Predictive Value of Mean Flow Velocity by TCD in Early Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage Completed NCT04329208
41 Identification of Novel Molecular Markers for Vasospasm From the Cerebrospinal Fluid (CSF) of Patients With Aneurysmal Subarachnoid Hemorrhage Completed NCT02389634
42 Evaluation of the Efficacy of Transcutaneous Trigeminal Nerve Stimulation for Prevention of Cerebral Vasospasm and Its Consequences After Subarachnoid Haemorrhage Due to Ruptured Aneurysm: a Multicentre, Randomized, Double-blind Study Completed NCT02482883
43 A Non-Randomized, Non-Significant Risk Study Comparing the Nautilus NeuroWaveTM System to Transcranial Doppler as an Aid to Diagnosing Vasospasm Completed NCT01595802
44 The Vesalio Neva VS for the Treatment of Symptomatic Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage (aSAH) (The VITAL Study) Recruiting NCT03611790
45 Safety of Intravenous Milrinone for the Treatment of Subarachnoid Hemorrhage-induced Vasospasm Recruiting NCT03517670
46 Lumbar Drainage Compared With Extraventricular Drainage of Cerebral Spinal Fluid in Treatment of Patients With Subarachnoid Hemorrhage - a Prospective Randomized Controlled Trial Recruiting NCT03065231
47 Contrast Enhanced Ultrasound Imaging for Cerebral Perfusion Measurement in Cerebral Vasospasm After Subarachnoid Hemorrhage Recruiting NCT02907879
48 CT Perfusion Imaging to Predict Vasospasm in Subarachnoid Hemorrhage Active, not recruiting NCT02056769
49 Inhibition of Lipid Peroxidation and Cerebral Vasospasm by an Acetaminophen-Based Regimen in Patients With Aneurysmal Subarachnoid Hemorrhage Enrolling by invitation NCT00585559 Placebos for acetaminophen and N-acetylcysteine;APAP 1 gm every 6 hours and N-acetylcysteine placebo;NAC IV infusion at 0.5 gm hourly and APAP placebo;APAP 1 gm q6 hours, plus NAC IV infusion at 0.5 gm hourly;APAP 1.5 gm q6 hours, plus NAC IV infusion at 0.5 gm hourly
50 "The Effect of Stellate Ganglion Block on Brain Haemodynamics and the Inflammatory Response in Moderate and Severe Brain Injury" Not yet recruiting NCT04208477

Search NIH Clinical Center for Intracranial Vasospasm

Cochrane evidence based reviews: vasospasm, intracranial

Genetic Tests for Intracranial Vasospasm

Anatomical Context for Intracranial Vasospasm

MalaCards organs/tissues related to Intracranial Vasospasm:

40
Brain, Spinal Cord

Publications for Intracranial Vasospasm

Articles related to Intracranial Vasospasm:

(show all 49)
# Title Authors PMID Year
1
Use of stent retriever for treatment of iatrogenic intracranial vasospasm. 61
31088245 2019
2
Vasospasm as a major complication after acute mechanical thrombectomy with stent retrievers. 61
30904242 2019
3
Migrainous Infarction And Cerebral Vasospasm: Case Report And Literature Review. 61
31695483 2019
4
Extracranial internal carotid artery vasospasm during thrombectomy. 61
28895453 2018
5
Delayed Vasospasm after Aneurysmal Subarachnoid Hemorrhage in Behcet Syndrome. 61
27114963 2016
6
Intracranial Vasospasm without Intracranial Hemorrhage due to Acute Spontaneous Spinal Subdural Hematoma. 61
26713084 2015
7
Role of Genetic Polymorphisms in Predicting Delayed Cerebral Ischemia and Radiographic Vasospasm After Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis. 61
26074429 2015
8
Treatment of intracranial vasospasm following subarachnoid hemorrhage. 61
24904517 2014
9
Safety of early endovascular catheterization and intervention through extracranial-intracranial bypass grafts. 61
21942723 2012
10
Percutaneous transluminal angioplasty in a patient with vasospasm secondary to coccidioidal meningitis: case report and review of the literature. 61
21990792 2011
11
Ultrahigh-dose intraarterial infusion of verapamil through an indwelling microcatheter for medically refractory severe vasospasm: initial experience. Clinical article. 61
19877802 2010
12
Intracranial vasospasm with delayed ischaemic deficit following epidermoid cyst resection. 61
20603397 2010
13
[Aneurysmal subarachonid haemorrhage]. 61
20533231 2010
14
Intracranial vasospasm with subsequent stroke after traumatic subarachnoid hemorrhage in a 22-month-old child. 61
19338410 2009
15
Anesthetic considerations of selective intra-arterial nicardipine injection for intracranial vasospasm: a case series. 61
17413999 2007
16
Clinical utility of multislice computed tomographic angiography for detection of cerebral vasospasm in acute subarachnoid hemorrhage. 61
17163342 2006
17
Delayed intracranial vasospasm following carotid endarterectomy. 61
16088117 2005
18
[Reversible posterior leukoencephalopathy syndrome: experience in 3 cases]. 61
15729881 2004
19
Successful treatment of cerebral vasospasm by use of transdermal nitroglycerin ointment (Nitropaste). 61
12812961 2003
20
[Clinical use of transcranial Doppler in critical neurological patients. Results of a multicenter study]. 61
12622997 2003
21
Cerebral angiography in the rat with mammographic equipment: a simple, cost-effective method for assessing vasospasm in experimental subarachnoid haemorrhage. 61
12185547 2002
22
Symptomatic vasospasm after subarachnoid haemorrhage: assessment of brain damage by diffusion and perfusion-weighted MRI and single-photon emission computed tomography. 61
12136364 2002
23
[Transcranial Doppler imaging: state of the art]. 61
11507445 2001
24
Vasospasm after subarachnoid hemorrhage: diagnosis with MR angiography. 61
11039339 2000
25
Intracranial angioplasty and thrombolysis. 61
10565870 2000
26
Transcranial color-coded duplex sonography. 61
10460438 1999
27
Nonaneurysmal thunderclap headache with diffuse, multifocal, segmental, and reversible vasospasm. 61
10214538 1999
28
Cerebrovascular ultrasound. 61
10097886 1999
29
Diffuse cerebral vasospasm with ischemia after resection of a cerebellopontine angle primitive neuroectodermal tumor in a child. 61
9973676 1998
30
Three-dimensional CT angiography of intracranial vasospasm following subarachnoid haemorrhage. 61
9833891 1998
31
Suppression of HIV-1 replication in peripheral blood mononuclear cells by fasudil. 61
9597811 1998
32
CT angiography of cerebral vasospasm with conventional angiographic comparison. 61
9111662 1997
33
MR angiography of cerebral vasospasm in preeclampsia. 61
7677037 1995
34
Fatal cerebellar infarction in a migraine sufferer whilst receiving sumatriptan. 61
7560482 1995
35
Severe diffuse intracranial vasospasm as a cause of extensive migrainous cerebral infarction. 61
8374945 1993
36
Role of transcranial Doppler in neuroradiological treatment of intracranial vasospasm. 61
8421832 1993
37
Effects of dobutamine and dopamine on whole brain blood flow and metabolism in unanesthetized monkeys. 61
15815473 1992
38
Intraarterial papaverine for relief of catheter-induced intracranial vasospasm. 61
1546611 1992
39
[Management of intracranial vasospasm in rupture of cerebral aneurysm]. 61
1811186 1991
40
Cerebral vasospasm evaluated by transcranial Doppler ultrasonography at different intracranial pressures. 61
1919698 1991
41
[A model for intracranial vasospasm in subarachnoid hemorrhage]. 61
2017293 1991
42
Migrainous stroke. 61
3337678 1988
43
[Relief of experimental cerebral vasospasm by the intrathecal administration of a calcium antagonist (diltiazem)--in comparison with intra-arterial administration]. 61
3840580 1985
44
Early aneurysm operation and vasospasm. Intracranial Doppler findings. 61
3892347 1985
45
Bilateral cervical carotid and intracranial vasospasm causing cerebral ischemia in a migrainous patient: a case of "diplegic migraine". 61
6490360 1984
46
[Traumatic intraclinoidal aneurysm of the internal carotid artery]. 61
7123690 1982
47
Intracranial vasospasm: a study with iron compounds. 61
35848 1979
48
Vasoconstriction of external carotid arteries after rupture of intracranial aneurysms. 61
517197 1979
49
The relief of intracranial vasospasm: an experimental study with methylprednisolone and cortisol. 61
806982 1975

Variations for Intracranial Vasospasm

Expression for Intracranial Vasospasm

Search GEO for disease gene expression data for Intracranial Vasospasm.

Pathways for Intracranial Vasospasm

GO Terms for Intracranial Vasospasm

Sources for Intracranial Vasospasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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