MCID: INT015
MIFTS: 27

Intracystic Papillary Adenoma

Categories: Cancer diseases

Aliases & Classifications for Intracystic Papillary Adenoma

MalaCards integrated aliases for Intracystic Papillary Adenoma:

Name: Intracystic Papillary Adenoma 12 15 73
Intracystic Papilloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2682
NCIt 50 C4191
SNOMED-CT 68 47488001
UMLS 73 C0334374

Summaries for Intracystic Papillary Adenoma

MalaCards based summary : Intracystic Papillary Adenoma, also known as intracystic papilloma, is related to papillary carcinoma and gallbladder squamous cell carcinoma, and has symptoms including nipple discharge An important gene associated with Intracystic Papillary Adenoma is GSTO1 (Glutathione S-Transferase Omega 1), and among its related pathways/superpathways are ErbB4 Pathway and Gastric cancer. Related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Related Diseases for Intracystic Papillary Adenoma

Diseases related to Intracystic Papillary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 papillary carcinoma 29.1 ERBB2 PGR
2 gallbladder squamous cell carcinoma 10.3 CEACAM5 ERBB2
3 vulval paget's disease 10.3 CEACAM5 ERBB2
4 vulva adenocarcinoma 10.3 CEACAM5 ERBB2
5 ovary adenocarcinoma 10.3 CEACAM5 ERBB2
6 granulosa cell tumor of the ovary 10.3 ERBB2 PRL
7 scirrhous adenocarcinoma 10.2 ERBB2 PGR
8 breast apocrine carcinoma 10.2 ERBB2 PGR
9 glassy cell carcinoma of the cervix 10.2 ERBB2 PGR
10 breast metaplastic carcinoma 10.2 ERBB2 PGR
11 breast medullary carcinoma 10.2 ERBB2 PGR
12 progesterone-receptor positive breast cancer 10.2 ERBB2 PGR
13 apocrine adenocarcinoma 10.2 ERBB2 PGR
14 uterine body mixed cancer 10.2 ERBB2 PGR
15 uterine corpus cancer 10.2 ERBB2 PGR
16 breast benign neoplasm 10.2 ERBB2 PGR
17 thoracic benign neoplasm 10.2 ERBB2 PGR
18 ovarian cancer 1 10.2 CEACAM5 ERBB2
19 mixed cell type cancer 10.2 ERBB2 PGR
20 granulomatous endometritis 10.2 CEACAM5 PGR
21 breast secretory carcinoma 10.2 ERBB2 PGR
22 gastric signet ring cell adenocarcinoma 10.1 CEACAM5 PGR
23 adenoid basal cell carcinoma 10.1 CEACAM5 PGR
24 sella turcica neoplasm 10.1 PGR PRL
25 pancreatic serous cystadenoma 10.1 CEACAM5 PGR
26 tuberculum sellae meningioma 10.1 PGR PRL
27 mammographic density 10.1 PGR PRL
28 bilateral breast cancer 10.1 ERBB2 PGR
29 adenomyosis 10.1 PGR PRL
30 cervical clear cell adenocarcinoma 10.1 CEACAM5 PGR
31 breast papillary carcinoma 10.1 ERBB2 PGR
32 spermatocele 10.1 CEACAM5 PGR
33 fallopian tube carcinoma 10.1 ERBB2 PGR
34 sweat gland cancer 10.1 ERBB2 PGR
35 congenital epulis 10.1 CEACAM5 PGR
36 pancreatic mucinous cystadenoma 10.1 CEACAM5 PGR
37 estrogen-receptor negative breast cancer 10.1 ERBB2 PGR
38 breast fibroadenoma 10.0 ERBB2 PGR
39 premenstrual tension 10.0 PGR PRL
40 female breast cancer 10.0 ERBB2 PGR
41 papilloma 10.0
42 serous cystadenocarcinoma 10.0 ERBB2 PGR
43 breast intraductal proliferative lesion 10.0 EGFR ERBB2
44 gynecomastia 10.0 PGR PRL
45 cell type benign neoplasm 9.9 CEACAM5 PRL
46 acneiform dermatitis 9.9 EGFR ERBB2
47 adenosquamous cell lung carcinoma 9.9 EGFR ERBB2
48 hidradenocarcinoma 9.9 EGFR ERBB2
49 female reproductive system disease 9.9 PGR PRL
50 gallbladder adenocarcinoma 9.9 EGFR ERBB2

Graphical network of the top 20 diseases related to Intracystic Papillary Adenoma:



Diseases related to Intracystic Papillary Adenoma

Symptoms & Phenotypes for Intracystic Papillary Adenoma

UMLS symptoms related to Intracystic Papillary Adenoma:


nipple discharge

GenomeRNAi Phenotypes related to Intracystic Papillary Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.8 EGFR ERBB2
2 Decreased viability with paclitaxel GR00179-A-3 8.8 EGFR

MGI Mouse Phenotypes related to Intracystic Papillary Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 EGFR ERBB2 PGR PRL

Drugs & Therapeutics for Intracystic Papillary Adenoma

Search Clinical Trials , NIH Clinical Center for Intracystic Papillary Adenoma

Genetic Tests for Intracystic Papillary Adenoma

Anatomical Context for Intracystic Papillary Adenoma

Publications for Intracystic Papillary Adenoma

Articles related to Intracystic Papillary Adenoma:

# Title Authors Year
1
Intracystic papilloma of the breast. ( 22764674 )
2012
2
Intracystic papillary carcinoma of breast harbors significant genomic alteration compared with intracystic papilloma: genome-wide copy number and LOH analysis using high-density single-nucleotide polymorphism microarrays. ( 21651641 )
2011

Variations for Intracystic Papillary Adenoma

Expression for Intracystic Papillary Adenoma

Search GEO for disease gene expression data for Intracystic Papillary Adenoma.

Pathways for Intracystic Papillary Adenoma

GO Terms for Intracystic Papillary Adenoma

Cellular components related to Intracystic Papillary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basal plasma membrane GO:0009925 8.96 EGFR ERBB2
2 basolateral plasma membrane GO:0016323 8.8 CEACAM5 EGFR ERBB2

Biological processes related to Intracystic Papillary Adenoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.61 EGFR ERBB2 PRL
2 positive regulation of cell growth GO:0030307 9.54 EGFR ERBB2
3 signal transduction by protein phosphorylation GO:0023014 9.52 EGFR ERBB2
4 positive regulation of kinase activity GO:0033674 9.51 EGFR ERBB2
5 cell surface receptor signaling pathway GO:0007166 9.5 EGFR ERBB2 PRL
6 positive regulation of MAP kinase activity GO:0043406 9.49 EGFR ERBB2
7 positive regulation of epithelial cell proliferation GO:0050679 9.48 EGFR ERBB2
8 cellular response to growth factor stimulus GO:0071363 9.46 EGFR ERBB2
9 cellular response to epidermal growth factor stimulus GO:0071364 9.4 EGFR ERBB2
10 ERBB2 signaling pathway GO:0038128 9.37 EGFR ERBB2
11 mammary gland development GO:0030879 9.26 PGR PRL
12 regulation of cell motility GO:2000145 9.16 EGFR ERBB2
13 regulation of ERK1 and ERK2 cascade GO:0070372 8.96 EGFR ERBB2
14 negative regulation of ERBB signaling pathway GO:1901185 8.62 EGFR ERBB2

Molecular functions related to Intracystic Papillary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase kinase activity GO:0004709 9.4 EGFR ERBB2
2 protein phosphatase binding GO:0019903 9.37 EGFR ERBB2
3 mitogen-activated protein kinase kinase binding GO:0031434 9.32 EGFR ERBB2
4 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 EGFR ERBB2
5 identical protein binding GO:0042802 9.26 CEACAM5 EGFR ERBB2 PGR
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 EGFR ERBB2
7 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 8.62 EGFR ERBB2

Sources for Intracystic Papillary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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