MCID: INT340
MIFTS: 25

Intraductal Breast Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Intraductal Breast Neoplasm

MalaCards integrated aliases for Intraductal Breast Neoplasm:

Name: Intraductal Breast Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3013
NCIt 49 C36083
UMLS 71 C0948967

Summaries for Intraductal Breast Neoplasm

Disease Ontology : 12 A breast benign neoplasm that is located in the breast ducts.

MalaCards based summary : Intraductal Breast Neoplasm is related to breast intraductal proliferative lesion and enchondroma. An important gene associated with Intraductal Breast Neoplasm is CT45A10 (Cancer/Testis Antigen Family 45 Member A10), and among its related pathways/superpathways are Signaling by ERBB4 and Glucocorticoid receptor regulatory network. Affiliated tissues include breast ducts, breast and brain, and related phenotypes are limbs/digits/tail and neoplasm

Related Diseases for Intraductal Breast Neoplasm

Diseases related to Intraductal Breast Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 256)
# Related Disease Score Top Affiliating Genes
1 breast intraductal proliferative lesion 32.7 CT45A10 ADH6
2 enchondroma 10.5 IDH2 IDH1
3 cytogenetically normal acute myeloid leukemia 10.5 IDH2 IDH1
4 intracranial chondrosarcoma 10.5 IDH2 IDH1
5 adult brain stem glioma 10.5 IDH2 IDH1
6 central nervous system rhabdomyosarcoma 10.5 IDH2 IDH1
7 periosteal chondrosarcoma 10.5 IDH2 IDH1
8 breast cystic hypersecretory carcinoma 10.5 KRT5 ERBB2
9 juxtacortical chondroma 10.5 IDH2 IDH1
10 vulva basal cell carcinoma 10.5 KRT5 ERBB2
11 scirrhous adenocarcinoma 10.5 PGR ERBB2
12 adult oligodendroglioma 10.5 IDH2 IDH1
13 bartholin's gland adenoid cystic carcinoma 10.5 PGR ESR1
14 chronic tympanitis 10.5 PGR ESR1
15 benign breast adenomyoepithelioma 10.5 KRT5 KRT14
16 breast adenomyoepithelioma 10.5 KRT5 KRT14
17 granulomatous endometritis 10.5 PGR ESR1
18 external ear carcinoma 10.5 PGR KRT5
19 lung leiomyoma 10.5 PGR ESR1
20 vulvar syringoma 10.5 PGR ESR1
21 trigonitis 10.5 PGR ESR1
22 cerebellar astrocytoma 10.5 IDH2 IDH1
23 childhood oligodendroglioma 10.5 IDH2 IDH1
24 vagina leiomyosarcoma 10.5 PGR ESR1
25 ceruminous adenocarcinoma 10.5 KRT5 KRT14
26 breast adenoid cystic carcinoma 10.5 PGR ERBB2
27 adult type testicular granulosa cell tumor 10.5 PGR ESR1
28 cervical clear cell adenocarcinoma 10.4 PGR KRT14
29 breast myoepithelial neoplasm 10.4 KRT5 KRT14
30 interval angle-closure glaucoma 10.4 IDH2 IDH1
31 esophageal adenosquamous carcinoma 10.4 KRT5 ERBB2
32 liver leiomyoma 10.4 PGR ESR1
33 clear cell chondrosarcoma 10.4 IDH2 IDH1
34 epidermolysis bullosa simplex, autosomal recessive 1 10.4 KRT5 KRT14
35 linitis plastica 10.4 PGR ERBB2
36 odontoma 10.4 KRT5 KRT14
37 mammographic density 10.4 PGR ESR1
38 vulvar leiomyoma 10.4 PGR ESR1
39 undifferentiated pleomorphic sarcoma 10.4 IDH2 IDH1
40 breast duct papilloma 10.4 PGR IDH2 IDH1
41 polyp of corpus uteri 10.4 PGR KRT14
42 chondroblastic osteosarcoma 10.4 IDH2 IDH1
43 rete ovarii adenoma 10.4 PGR KRT14
44 epidermolysis bullosa simplex with mottled pigmentation 10.4 KRT5 KRT14
45 rete ovarii neoplasm 10.4 PGR KRT14
46 papillary adenoma 10.4 TP53 KRT5
47 lipid-rich breast carcinoma 10.4 PGR KRT5 ERBB2
48 benign peritoneal mesothelioma 10.4 KRT5 KRT14
49 breast mucinous carcinoma 10.3 PGR KRT5 ERBB2
50 epidermolysis bullosa simplex, generalized 10.3 KRT5 KRT14

Graphical network of the top 20 diseases related to Intraductal Breast Neoplasm:



Diseases related to Intraductal Breast Neoplasm

Symptoms & Phenotypes for Intraductal Breast Neoplasm

MGI Mouse Phenotypes related to Intraductal Breast Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.43 ERBB2 ESR1 IDH2 KRT5 PGR TP53
2 neoplasm MP:0002006 9.17 ERBB2 ESR1 IDH2 KRT14 MFSD1 PGR

Drugs & Therapeutics for Intraductal Breast Neoplasm

Search Clinical Trials , NIH Clinical Center for Intraductal Breast Neoplasm

Genetic Tests for Intraductal Breast Neoplasm

Anatomical Context for Intraductal Breast Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Intraductal Breast Neoplasm:

19
Breast Ducts

MalaCards organs/tissues related to Intraductal Breast Neoplasm:

40
Breast, Brain, Ovary, Lung, Skin, Cervix, Myeloid

Publications for Intraductal Breast Neoplasm

Variations for Intraductal Breast Neoplasm

Expression for Intraductal Breast Neoplasm

Search GEO for disease gene expression data for Intraductal Breast Neoplasm.

Pathways for Intraductal Breast Neoplasm

Pathways related to Intraductal Breast Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.47 PGR ESR1 ERBB2
2 11.05 TP53 KRT5 KRT14
3 10.64 TP53 IDH1 ERBB2
4
Show member pathways
10.27 IDH2 IDH1

GO Terms for Intraductal Breast Neoplasm

Biological processes related to Intraductal Breast Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 2-oxoglutarate metabolic process GO:0006103 9.43 IDH2 IDH1
2 replicative senescence GO:0090399 9.4 TP53 MME
3 hemidesmosome assembly GO:0031581 9.37 KRT5 KRT14
4 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.32 TP53 ESR1
5 NADP metabolic process GO:0006739 9.26 IDH2 IDH1
6 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.16 TP53 ESR1
7 isocitrate metabolic process GO:0006102 8.96 IDH2 IDH1
8 glyoxylate cycle GO:0006097 8.62 IDH2 IDH1

Molecular functions related to Intraductal Breast Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
2 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1

Sources for Intraductal Breast Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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