MCID: INT340
MIFTS: 21

Intraductal Breast Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Intraductal Breast Neoplasm

MalaCards integrated aliases for Intraductal Breast Neoplasm:

Name: Intraductal Breast Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3013
NCIt 50 C36083
UMLS 72 C0948967

Summaries for Intraductal Breast Neoplasm

Disease Ontology : 12 A breast benign neoplasm that is located in the breast ducts.

MalaCards based summary : Intraductal Breast Neoplasm is related to breast intraductal proliferative lesion and interval angle-closure glaucoma. An important gene associated with Intraductal Breast Neoplasm is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), and among its related pathways/superpathways are Signaling by ERBB4 and Cytosine methylation. Affiliated tissues include breast and breast ducts, and related phenotype is neoplasm.

Related Diseases for Intraductal Breast Neoplasm

Diseases related to Intraductal Breast Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 breast intraductal proliferative lesion 11.5
2 interval angle-closure glaucoma 10.6 IDH2 IDH1
3 enchondroma 10.6 IDH2 IDH1
4 adult oligodendroglioma 10.6 IDH2 IDH1
5 intracranial chondrosarcoma 10.6 IDH2 IDH1
6 cytogenetically normal acute myeloid leukemia 10.6 IDH2 IDH1
7 chondroblastic osteosarcoma 10.6 IDH2 IDH1
8 multiple enchondromatosis, maffucci type 10.5 IDH2 IDH1
9 spindle cell hemangioma 10.5 IDH2 IDH1
10 pilocytic astrocytoma of cerebellum 10.5 IDH2 IDH1
11 periosteal chondrosarcoma 10.5 IDH2 IDH1
12 fibrillary astrocytoma 10.5 IDH2 IDH1
13 adult astrocytic tumour 10.5 IDH2 IDH1
14 diffuse infiltrative lymphocytosis syndrome 10.5 IDH2 IDH1
15 lymphoepithelioma-like thymic carcinoma 10.5 KRT5 IDH1
16 undifferentiated pleomorphic sarcoma 10.5 IDH2 IDH1
17 drug psychosis 10.5 IDH2 IDH1
18 drug-induced mental disorder 10.5 IDH2 IDH1
19 breast cystic hypersecretory carcinoma 10.5 KRT5 ERBB2
20 benign breast adenomyoepithelioma 10.4 KRT5 KRT14
21 breast adenomyoepithelioma 10.4 KRT5 KRT14
22 lichen planopilaris 10.4 KRT5 KRT14
23 epidermolysis bullosa simplex, autosomal recessive 1 10.4 KRT5 KRT14
24 epidermolysis bullosa simplex 10.4 KRT5 KRT14
25 large cell acanthoma 10.4 KRT5 KRT14
26 apocrine sweat gland neoplasm 10.4 KRT5 KRT14
27 2-hydroxyglutaric aciduria 10.4 IDH2 IDH1
28 epidermolysis bullosa simplex, localized 10.4 KRT5 KRT14
29 d-2-hydroxyglutaric aciduria 1 10.4 IDH2 IDH1
30 epidermolysis bullosa simplex, generalized 10.4 KRT5 KRT14
31 epidermolysis bullosa simplex with mottled pigmentation 10.4 KRT5 KRT14
32 odontoma 10.4 KRT5 KRT14
33 bile duct adenocarcinoma 10.4 IDH2 IDH1
34 breast myoepithelial neoplasm 10.4 KRT5 KRT14
35 breast apocrine carcinoma 10.4 PGR ERBB2
36 scirrhous adenocarcinoma 10.4 PGR ERBB2
37 enchondromatosis, multiple, ollier type 10.3 IDH2 IDH1
38 vesiculobullous skin disease 10.3 KRT5 KRT14
39 intracystic papillary adenoma 10.3 PGR ERBB2
40 lipoadenoma 10.3 KRT5 KRT14
41 progesterone-receptor negative breast cancer 10.3 PGR ERBB2
42 pregnancy adenoma 10.3 KRT5 KRT14
43 epidermolysis bullosa simplex, dowling-meara type 10.3 KRT5 KRT14
44 uterine body mixed cancer 10.3 PGR ERBB2
45 intraneural perineurioma 10.3 KRT5 KRT14
46 microglandular adenosis 10.3 PGR ERBB2
47 brain stem glioma 10.2 IDH2 IDH1
48 comedo carcinoma 10.2 ESR1 ERBB2
49 glioma susceptibility 1 10.2 IDH2 IDH1 ERBB2
50 glioma 10.2 IDH2 IDH1 ERBB2

Graphical network of the top 20 diseases related to Intraductal Breast Neoplasm:



Diseases related to Intraductal Breast Neoplasm

Symptoms & Phenotypes for Intraductal Breast Neoplasm

MGI Mouse Phenotypes related to Intraductal Breast Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.1 DOCK4 ERBB2 ESR1 IDH2 KRT14 PGR

Drugs & Therapeutics for Intraductal Breast Neoplasm

Search Clinical Trials , NIH Clinical Center for Intraductal Breast Neoplasm

Genetic Tests for Intraductal Breast Neoplasm

Anatomical Context for Intraductal Breast Neoplasm

MalaCards organs/tissues related to Intraductal Breast Neoplasm:

41
Breast

The Foundational Model of Anatomy Ontology organs/tissues related to Intraductal Breast Neoplasm:

19
Breast Ducts

Publications for Intraductal Breast Neoplasm

Variations for Intraductal Breast Neoplasm

Expression for Intraductal Breast Neoplasm

Search GEO for disease gene expression data for Intraductal Breast Neoplasm.

Pathways for Intraductal Breast Neoplasm

Pathways related to Intraductal Breast Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.83 PGR ESR1 ERBB2
2
Show member pathways
10.07 IDH2 IDH1

GO Terms for Intraductal Breast Neoplasm

Cellular components related to Intraductal Breast Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.56 PRUNE2 PGR KRT5 KRT14 IDH1 ESR1
2 cytosol GO:0005829 9.23 PGR KRT5 KRT14 IDH2 IDH1 ESR1

Biological processes related to Intraductal Breast Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone mediated signaling pathway GO:0043401 9.4 PGR ESR1
2 tricarboxylic acid cycle GO:0006099 9.37 IDH2 IDH1
3 2-oxoglutarate metabolic process GO:0006103 9.32 IDH2 IDH1
4 hemidesmosome assembly GO:0031581 9.26 KRT5 KRT14
5 NADP metabolic process GO:0006739 9.16 IDH2 IDH1
6 isocitrate metabolic process GO:0006102 8.96 IDH2 IDH1
7 glyoxylate cycle GO:0006097 8.62 IDH2 IDH1

Molecular functions related to Intraductal Breast Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.4 PGR ESR1
2 nuclear receptor activity GO:0004879 9.37 PGR ESR1
3 NAD binding GO:0051287 9.32 IDH2 IDH1
4 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.26 IDH2 IDH1
5 steroid binding GO:0005496 9.16 PGR ESR1
6 isocitrate dehydrogenase activity GO:0004448 8.96 IDH2 IDH1
7 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH2 IDH1

Sources for Intraductal Breast Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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