MCID: INT340
MIFTS: 25

Intraductal Breast Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Intraductal Breast Neoplasm

MalaCards integrated aliases for Intraductal Breast Neoplasm:

Name: Intraductal Breast Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3013
NCIt 51 C36083
UMLS 74 C0948967

Summaries for Intraductal Breast Neoplasm

Disease Ontology : 12 A breast benign neoplasm that is located in the breast ducts.

MalaCards based summary : Intraductal Breast Neoplasm is related to breast intraductal proliferative lesion and interval angle-closure glaucoma. An important gene associated with Intraductal Breast Neoplasm is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways/superpathways are Central carbon metabolism in cancer and Signaling by ERBB4. Affiliated tissues include breast and the breast ducts, and related phenotypes are limbs/digits/tail and neoplasm

Related Diseases for Intraductal Breast Neoplasm

Diseases related to Intraductal Breast Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 breast intraductal proliferative lesion 11.3
2 interval angle-closure glaucoma 10.3 IDH1 IDH2
3 adult oligodendroglioma 10.3 IDH1 IDH2
4 enchondroma 10.3 IDH1 IDH2
5 intracranial chondrosarcoma 10.3 IDH1 IDH2
6 cytogenetically normal acute myeloid leukemia 10.3 IDH1 IDH2
7 chondroblastic osteosarcoma 10.3 IDH1 IDH2
8 multiple enchondromatosis, maffucci type 10.3 IDH1 IDH2
9 pilocytic astrocytoma of cerebellum 10.3 IDH1 IDH2
10 spindle cell hemangioma 10.3 IDH1 IDH2
11 periosteal chondrosarcoma 10.3 IDH1 IDH2
12 adult astrocytic tumour 10.3 IDH1 IDH2
13 fibrillary astrocytoma 10.3 IDH1 IDH2
14 diffuse infiltrative lymphocytosis syndrome 10.3 IDH1 IDH2
15 lymphoepithelioma-like thymic carcinoma 10.3 IDH1 KRT5
16 drug-induced mental disorder 10.3 IDH1 IDH2
17 drug psychosis 10.3 IDH1 IDH2
18 undifferentiated pleomorphic sarcoma 10.3 IDH1 IDH2
19 2-hydroxyglutaric aciduria 10.2 IDH1 IDH2
20 d-2-hydroxyglutaric aciduria 1 10.2 IDH1 IDH2
21 bile duct adenocarcinoma 10.2 IDH1 IDH2
22 enchondromatosis, multiple, ollier type 10.2 IDH1 IDH2
23 vestibular gland benign neoplasm 10.2 ESR1 PGR
24 bartholin's gland adenoma 10.2 ESR1 PGR
25 vulvar syringoma 10.2 ESR1 PGR
26 lung leiomyoma 10.2 ESR1 PGR
27 myoma 10.2 ESR1 PGR
28 vulvar benign neoplasm 10.2 ESR1 PGR
29 trigonitis 10.2 ESR1 PGR
30 vulvar leiomyoma 10.2 ESR1 PGR
31 sweat gland disease 10.2 KRT5 PGR
32 predominantly cortical thymoma 10.2 ESR1 PGR
33 bartholin's gland benign neoplasm 10.2 ESR1 PGR
34 oncocytic breast carcinoma 10.2 ESR1 PGR
35 progesterone resistance 10.2 ESR1 PGR
36 endometrial squamous cell carcinoma 10.2 ESR1 PGR
37 cribriform carcinoma 10.2 ESR1 PGR
38 endometrial mucinous adenocarcinoma 10.2 ESR1 PGR
39 adenoid basal cell carcinoma 10.2 ESR1 PGR
40 peritoneal benign neoplasm 10.2 ESR1 PGR
41 gender identity disorder 10.2 ESR1 PGR
42 deep angioma 10.2 ESR1 PGR
43 diffuse peritoneal leiomyomatosis 10.2 ESR1 PGR
44 leiomyomatosis 10.2 ESR1 PGR
45 synchronous bilateral breast carcinoma 10.2 ESR1 PGR
46 brain stem glioma 10.1 IDH1 IDH2
47 female reproductive endometrioid cancer 10.1 ESR1 PGR
48 cervical carcinosarcoma 10.1 ESR1 PGR
49 estrogen excess 10.1 ESR1 PGR
50 breast cystic hypersecretory carcinoma 10.1 ERBB2 KRT5

Graphical network of the top 20 diseases related to Intraductal Breast Neoplasm:



Diseases related to Intraductal Breast Neoplasm

Symptoms & Phenotypes for Intraductal Breast Neoplasm

MGI Mouse Phenotypes related to Intraductal Breast Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.26 ERBB2 ESR1 KRT5 PGR
2 neoplasm MP:0002006 9.02 DOCK4 ERBB2 ESR1 IDH2 PGR

Drugs & Therapeutics for Intraductal Breast Neoplasm

Search Clinical Trials , NIH Clinical Center for Intraductal Breast Neoplasm

Genetic Tests for Intraductal Breast Neoplasm

Anatomical Context for Intraductal Breast Neoplasm

MalaCards organs/tissues related to Intraductal Breast Neoplasm:

42
Breast

The Foundational Model of Anatomy Ontology organs/tissues related to Intraductal Breast Neoplasm:

20
The Breast Ducts

Publications for Intraductal Breast Neoplasm

Variations for Intraductal Breast Neoplasm

Expression for Intraductal Breast Neoplasm

Search GEO for disease gene expression data for Intraductal Breast Neoplasm.

Pathways for Intraductal Breast Neoplasm

Pathways related to Intraductal Breast Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.97 ERBB2 IDH1
2
Show member pathways
10.83 ERBB2 ESR1 PGR
3
Show member pathways
10.07 IDH1 IDH2

GO Terms for Intraductal Breast Neoplasm

Cellular components related to Intraductal Breast Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.17 DOCK4 ERBB2 ESR1 IDH1 IDH2 KRT5

Biological processes related to Intraductal Breast Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone mediated signaling pathway GO:0043401 9.37 ESR1 PGR
2 tricarboxylic acid cycle GO:0006099 9.32 IDH1 IDH2
3 2-oxoglutarate metabolic process GO:0006103 9.26 IDH1 IDH2
4 NADP metabolic process GO:0006739 9.16 IDH1 IDH2
5 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
6 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Intraductal Breast Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.4 ESR1 PGR
2 nuclear receptor activity GO:0004879 9.37 ESR1 PGR
3 NAD binding GO:0051287 9.32 IDH1 IDH2
4 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.26 IDH1 IDH2
5 steroid binding GO:0005496 9.16 ESR1 PGR
6 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
7 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Intraductal Breast Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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