MCID: INT016
MIFTS: 35

Intraductal Papilloma

Categories: Cancer diseases

Aliases & Classifications for Intraductal Papilloma

MalaCards integrated aliases for Intraductal Papilloma:

Name: Intraductal Papilloma 12 15
Papilloma, Intraductal 44 73
Papilloma Intraductal 55
Ductal Papilloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1627
MeSH 44 D018300
NCIt 50 C3785
SNOMED-CT 68 5244003
UMLS 73 C0206713

Summaries for Intraductal Papilloma

MalaCards based summary : Intraductal Papilloma, also known as papilloma, intraductal, is related to breast disease and breast duct papilloma. An important gene associated with Intraductal Papilloma is TP63 (Tumor Protein P63), and among its related pathways/superpathways are Peroxisome and Cytosine methylation. Affiliated tissues include breast, salivary gland and lymph node, and related phenotypes are cardiovascular system and neoplasm

Wikipedia : 76 Intraductal papillomas of the breast are benign lesions with an incidence of approximately 2-3% in... more...

Related Diseases for Intraductal Papilloma

Diseases related to Intraductal Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 breast disease 11.3
2 breast duct papilloma 11.2
3 papilloma 11.0
4 in situ carcinoma 10.4
5 ductal carcinoma in situ 10.4
6 papillary carcinoma 10.4
7 squamous cell papilloma 10.3
8 hidradenoma 10.1
9 polymorphous low-grade adenocarcinoma 10.1 MYH11 TP63
10 interval angle-closure glaucoma 10.1 IDH1 IDH2
11 adult oligodendroglioma 10.1 IDH1 IDH2
12 enchondroma 10.1 IDH1 IDH2
13 intracranial chondrosarcoma 10.1 IDH1 IDH2
14 cytogenetically normal acute myeloid leukemia 10.1 IDH1 IDH2
15 chondroblastic osteosarcoma 10.1 IDH1 IDH2
16 multiple enchondromatosis, maffucci type 10.1 IDH1 IDH2
17 pilocytic astrocytoma of cerebellum 10.1 IDH1 IDH2
18 spindle cell hemangioma 10.1 IDH1 IDH2
19 periosteal chondrosarcoma 10.1 IDH1 IDH2
20 glioma susceptibility 1 10.1 IDH1 IDH2
21 adult astrocytic tumour 10.1 IDH1 IDH2
22 spinal cord astrocytoma 10.1 CD44 IDH1
23 fibrillary astrocytoma 10.1 IDH1 IDH2
24 diffuse infiltrative lymphocytosis syndrome 10.1 IDH1 IDH2
25 drug-induced mental disorder 10.1 IDH1 IDH2
26 drug psychosis 10.1 IDH1 IDH2
27 undifferentiated pleomorphic sarcoma 10.1 IDH1 IDH2
28 2-hydroxyglutaric aciduria 10.1 IDH1 IDH2
29 d-2-hydroxyglutaric aciduria 1 10.0 IDH1 IDH2
30 bile duct adenocarcinoma 10.0 IDH1 IDH2
31 enchondromatosis, multiple, ollier type 10.0 IDH1 IDH2
32 brain stem glioma 10.0 IDH1 IDH2
33 loeys-dietz syndrome 3 10.0 MYH11 PRKG1
34 squamous cell carcinoma, head and neck 10.0 CD44 IDH2 TP63
35 breast cancer 10.0
36 hyperprolactinemia 10.0
37 breast fibroadenoma 10.0
38 benign breast phyllodes tumor 10.0
39 adenocarcinoma 10.0
40 papillary adenocarcinoma 10.0
41 breast metaplastic carcinoma 10.0
42 supratentorial cancer 10.0 CD44 IDH1 IDH2
43 cerebrum cancer 10.0 CD44 IDH1 IDH2
44 central nervous system cancer 9.9 IDH1 IDH2
45 cholangiocarcinoma 9.9 CD44 IDH1 IDH2
46 myeloma, multiple 9.9 CD44 IDH1 IDH2
47 adenoid cystic carcinoma 9.9 IDH1 MYH11 TP63
48 squamous cell carcinoma 9.9
49 papillary squamous carcinoma 9.9
50 aortic disease 9.9 MYH11 PRKG1

Graphical network of the top 20 diseases related to Intraductal Papilloma:



Diseases related to Intraductal Papilloma

Symptoms & Phenotypes for Intraductal Papilloma

MGI Mouse Phenotypes related to Intraductal Papilloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 CD44 DOCK4 IDH2 MYH11 PRKG1 TP63
2 neoplasm MP:0002006 8.92 CD44 DOCK4 IDH2 TP63

Drugs & Therapeutics for Intraductal Papilloma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or DCIS in Patients Diagnosed With Intraductal Papilloma Without Atypia or Flat Epithelial Atypia by Core Needle Biopsy Recruiting NCT02489617 Not Applicable
2 Feasibility and Therapeutic Efficacy of Ductoscopic Papilloma Extraction in Patients With Pathologic Nipple Discharge Recruiting NCT01901562 Not Applicable

Search NIH Clinical Center for Intraductal Papilloma

Cochrane evidence based reviews: papilloma, intraductal

Genetic Tests for Intraductal Papilloma

Anatomical Context for Intraductal Papilloma

MalaCards organs/tissues related to Intraductal Papilloma:

41
Breast, Salivary Gland, Lymph Node, Brain, Spinal Cord, Cerebellum, Myeloid

Publications for Intraductal Papilloma

Articles related to Intraductal Papilloma:

(show top 50) (show all 115)
# Title Authors Year
1
Intraductal papilloma arising from the accessory parotid gland: A case report and literature review. ( 29768362 )
2018
2
Mammographic and ultrasound findings in poroid hidradenoma of the breast mimicking intraductal papilloma and papillary carcinoma: A case report. ( 29924021 )
2018
3
Management of intraductal papilloma without atypia of the breast diagnosed on core biopsy: Size and sampling matter. ( 29687535 )
2018
4
Benign Intraductal Papilloma without Atypia on Core Needle Biopsy Has a Low Rate of Upgrading to Malignancy after Excision. ( 29628987 )
2018
5
Rare case of male breast intraductal papilloma progressing to invasive ductal carcinoma: A radiologic-pathologic correlation. ( 30073044 )
2018
6
Use of immunohistochemical analysis of CK5/6, CK14, and CK34betaE12 in the differential diagnosis of solid papillary carcinoma in situ from intraductal papilloma with usual ductal hyperplasia of the breast. ( 30455948 )
2018
7
Intraductal Papilloma Without Atypia on Image- Guided Breast Biopsy: Upgrade Rates to Carcinoma at Surgical Excision. ( 30498423 )
2018
8
Primary Osteosarcoma of the Breast Arising in an Intraductal Papilloma. ( 28713607 )
2017
9
Intraductal papilloma of the breast in an 11-year-old male patient: a case report. ( 28353086 )
2017
10
Challenging Atypical Breast Lesions Including Flat Epithelial Atypia, Radial Scar, and Intraductal Papilloma. ( 28766216 )
2017
11
Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor. ( 28648934 )
2017
12
The Management Strategy of Benign Solitary Intraductal Papilloma on Breast Core Biopsy. ( 28438672 )
2017
13
Apocrine Metaplasia in Intraductal Papilloma with Foci of DCIS: A Friend or Foe? ( 27499780 )
2016
14
Intraductal papilloma of the male breast. ( 26860828 )
2016
15
Intraductal Papilloma with Benign Pathology on Breast Core Biopsy: To Excise or Not? ( 26960929 )
2016
16
Floor of Mouth Mass. Intraductal papilloma. ( 26583524 )
2016
17
A Case of Intraductal Papilloma of the Breast With High 18F-FDG Uptake on PET/CT. ( 26164173 )
2015
18
Exuberant squamous metaplasia in an intraductal papilloma of breast. ( 25583984 )
2015
19
Immunocytochemical analysis of p63 and 34I^E12 in fine needle aspiration cytology specimens for breast lesions: a potentially useful discriminatory marker between intraductal papilloma and ductal carcinoma inA situ. ( 25810244 )
2015
20
The significance of combined CK5/6 and p63 immunohistochemistry in predicting the risks of subsequent carcinoma development in intraductal papilloma of the breast. ( 25572436 )
2015
21
A prolapsed intraductal papilloma: a case report. ( 28058341 )
2015
22
Diagnosis of a Nonpalpable Intraductal Papilloma without Radiological Abnormality by Nipple Discharge Smear Examination: A Case Report. ( 24737934 )
2014
23
Intraductal papilloma in an axillary lymph node of a patient with human immunodeficiency virus: a case report and review of the literature. ( 24884898 )
2014
24
MRI characteristics of intraductal papilloma. ( 24696194 )
2014
25
Mammotome biopsy in diagnosing and treatment of intraductal papilloma of the breast. ( 23640929 )
2013
26
Intraductal papilloma: atypical presentation. ( 23762648 )
2013
27
Concurrent fibroadenoma and intraductal papilloma - A recurring complex lesion in a premenarcheal girl. ( 23218483 )
2013
28
Combined evaluation of CK5/6, ER, p63, and MUC3 for distinguishing breast intraductal papilloma from ductal carcinoma in situ. ( 22612506 )
2012
29
Intraductal papilloma of the breast: A case report. ( 23396758 )
2012
30
Intraductal papilloma of the breast in association with preoncogenic gene of breast cancer. ( 23569749 )
2011
31
MRI features of intraductal papilloma of the breast: sheep in wolf's clothing? ( 21498361 )
2011
32
Glucose transporter expression of intraductal papilloma of the breast detected by fluorodeoxyglucose positron emission tomography. ( 21519997 )
2011
33
Is CD56 a specific and reliable neuroendocrine marker for discriminating between endocrine/neuroendocrine ductal carcinoma in situ and intraductal papilloma of the breast? ( 21166944 )
2011
34
Enlarging unilateral breast mass in an adolescent male: an unusual presentation of intraductal papilloma. ( 21616226 )
2011
35
Intraductal papilloma of ectopic breast tissue in axillary lymph node of a patient with a previous intraductal papilloma of ipsilateral breast: a case report and review of the literature. ( 20222992 )
2010
36
Evaluation of CD56 and CD57 immunostainings for discrimination between endocrine ductal carcinoma in situ and intraductal papilloma. ( 20518901 )
2010
37
Excision is indicated for intraductal papilloma of the breast diagnosed on core needle biopsy. ( 19402174 )
2009
38
Carcinoma in a solitary intraductal papilloma of the breast. ( 19261097 )
2009
39
External herniation of a subareolar intraductal papilloma: a rare, yet beneficial, complication of conventional ductography. ( 19913136 )
2009
40
"Signet-ring" cell invasive lobular carcinoma of the breast - accidental finding associated with intraductal papilloma: a case report. ( 19200374 )
2009
41
Ultrasound-guided vacuum-assisted breast biopsy system for diagnosis and minimally invasive excision of intraductal papilloma without nipple discharge. ( 19777298 )
2009
42
A potential diagnostic pitfall in aspiration cytology in intraductal papilloma of the parotid gland. ( 19697742 )
2009
43
Intraductal papilloma arising from sublingual minor salivary gland: case report and immunohistochemical study. ( 19426904 )
2009
44
Benign epithelial proliferations in axillary lymph nodes with ipsilateral breast in situ ductal carcinoma and intraductal papilloma of the breast. ( 18439159 )
2008
45
Complicated solitary intraductal papilloma of the breast. ( 17971167 )
2008
46
Intraoral intraductal papilloma: a case report. ( 18201187 )
2008
47
Intraductal carcinoma arising in intraductal papilloma in an axillary lymph node: review of the literature and proposed theories of evolution. ( 19061295 )
2008
48
Myoepithelial cells in solid variant of intraductal papillary carcinoma of the breast: a potential diagnostic pitfall and a proposal of an immunohistochemical panel in the differential diagnosis with intraductal papilloma with usual ductal hyperplasia. ( 17377808 )
2007
49
Intraductal papilloma of the parotid gland in a child. ( 17598121 )
2007
50
A case of solitary intraductal papilloma of the breast coexisting with ductal carcinoma in situ (DCIS). ( 27278180 )
2007

Variations for Intraductal Papilloma

Expression for Intraductal Papilloma

Search GEO for disease gene expression data for Intraductal Papilloma.

Pathways for Intraductal Papilloma

Pathways related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.87 IDH1 IDH2
2
Show member pathways
9.74 IDH1 IDH2

GO Terms for Intraductal Papilloma

Cellular components related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.17 CD44 DOCK4 IDH1 IDH2 MYH11 PRKG1

Biological processes related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.32 IDH1 IDH2
2 2-oxoglutarate metabolic process GO:0006103 9.26 IDH1 IDH2
3 NADP metabolic process GO:0006739 9.16 IDH1 IDH2
4 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
5 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 9.26 IDH1 IDH2
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH1 IDH2
3 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
4 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Intraductal Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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44 MeSH
45 MESH via Orphanet
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49 NCI
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51 NDF-RT
54 NINDS
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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