MCID: INT016
MIFTS: 36

Intraductal Papilloma

Categories: Cancer diseases

Aliases & Classifications for Intraductal Papilloma

MalaCards integrated aliases for Intraductal Papilloma:

Name: Intraductal Papilloma 12 15
Papilloma, Intraductal 45 74
Papilloma Intraductal 56
Ductal Papilloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1627
MeSH 45 D018300
NCIt 51 C3785
SNOMED-CT 69 5244003
UMLS 74 C0206713

Summaries for Intraductal Papilloma

MalaCards based summary : Intraductal Papilloma, also known as papilloma, intraductal, is related to in situ carcinoma and benign breast phyllodes tumor. An important gene associated with Intraductal Papilloma is TP63 (Tumor Protein P63), and among its related pathways/superpathways is Cytosine methylation. Affiliated tissues include salivary gland, brain and myeloid, and related phenotypes are Decreased viability in esophageal squamous lineage and cardiovascular system

Wikipedia : 77 Intraductal papillomas of the breast are benign lesions with an incidence of approximately 2-3% in... more...

Related Diseases for Intraductal Papilloma

Diseases related to Intraductal Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 in situ carcinoma 30.4 KRT5 PGR
2 benign breast phyllodes tumor 30.3 PGR TP63
3 ductal carcinoma in situ 30.2 KRT5 PGR
4 breast metaplastic carcinoma 29.9 KRT5 PGR
5 breast duct papilloma 11.6
6 breast disease 11.4
7 papilloma 11.0
8 squamous cell papilloma 11.0
9 papillary carcinoma 10.4
10 interval angle-closure glaucoma 10.2 IDH1 IDH2
11 adult oligodendroglioma 10.2 IDH1 IDH2
12 enchondroma 10.2 IDH1 IDH2
13 intracranial chondrosarcoma 10.2 IDH1 IDH2
14 cytogenetically normal acute myeloid leukemia 10.2 IDH1 IDH2
15 breast cancer 10.2
16 breast fibroadenoma 10.2
17 chondroblastic osteosarcoma 10.2 IDH1 IDH2
18 spinal cord astrocytoma 10.2 CD44 IDH1
19 cribriform carcinoma 10.2 PGR TP63
20 multiple enchondromatosis, maffucci type 10.2 IDH1 IDH2
21 pilocytic astrocytoma of cerebellum 10.2 IDH1 IDH2
22 spindle cell hemangioma 10.2 IDH1 IDH2
23 periosteal chondrosarcoma 10.2 IDH1 IDH2
24 glioma susceptibility 1 10.2 IDH1 IDH2
25 adult astrocytic tumour 10.2 IDH1 IDH2
26 fibrillary astrocytoma 10.2 IDH1 IDH2
27 diffuse infiltrative lymphocytosis syndrome 10.2 IDH1 IDH2
28 drug-induced mental disorder 10.2 IDH1 IDH2
29 drug psychosis 10.2 IDH1 IDH2
30 dermoid cyst 10.2 PGR TP63
31 undifferentiated pleomorphic sarcoma 10.2 IDH1 IDH2
32 polymorphous low-grade adenocarcinoma 10.2 MYH11 TP63
33 2-hydroxyglutaric aciduria 10.2 IDH1 IDH2
34 d-2-hydroxyglutaric aciduria 1 10.2 IDH1 IDH2
35 congenital epulis 10.2 CD44 PGR
36 bile duct adenocarcinoma 10.1 IDH1 IDH2
37 enchondromatosis, multiple, ollier type 10.1 IDH1 IDH2
38 hidradenoma 10.1
39 brain stem glioma 10.1 IDH1 IDH2
40 central nervous system cancer 10.1 IDH1 IDH2
41 nervous system cancer 10.0 IDH1 IDH2
42 supratentorial cancer 10.0 CD44 IDH1 IDH2
43 lipoadenoma 10.0 KRT5 TP63
44 cerebrum cancer 10.0 CD44 IDH1 IDH2
45 squamous cell carcinoma, head and neck 10.0 CD44 IDH2 TP63
46 necrotizing sialometaplasia 10.0 KRT5 TP63
47 hidradenocarcinoma 10.0 KRT5 TP63
48 loeys-dietz syndrome 3 10.0 MYH11 PRKG1
49 myeloma, multiple 10.0 CD44 IDH1 IDH2
50 cholangiocarcinoma 10.0 CD44 IDH1 IDH2

Graphical network of the top 20 diseases related to Intraductal Papilloma:



Diseases related to Intraductal Papilloma

Symptoms & Phenotypes for Intraductal Papilloma

GenomeRNAi Phenotypes related to Intraductal Papilloma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.1 CD44 IDH1 IDH2 PGR PRKG1 TP63

MGI Mouse Phenotypes related to Intraductal Papilloma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.88 CD44 IDH2 MYH11 PGR PRKG1 TP63
2 digestive/alimentary MP:0005381 9.77 CD44 KRT5 MYH11 PRKG1 TP63
3 integument MP:0010771 9.72 CD44 KRT5 MYH11 PGR TP63
4 mortality/aging MP:0010768 9.7 CD44 IDH1 KRT5 MYH11 PGR PRKG1
5 limbs/digits/tail MP:0005371 9.56 CD44 KRT5 PGR TP63
6 muscle MP:0005369 9.35 CD44 MYH11 PGR PRKG1 TP63
7 neoplasm MP:0002006 8.92 CD44 IDH2 PGR TP63

Drugs & Therapeutics for Intraductal Papilloma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or DCIS in Patients Diagnosed With Intraductal Papilloma Without Atypia or Flat Epithelial Atypia by Core Needle Biopsy Recruiting NCT02489617 Not Applicable
2 Feasibility and Therapeutic Efficacy of Ductoscopic Papilloma Extraction in Patients With Pathologic Nipple Discharge Recruiting NCT01901562 Not Applicable
3 Volumetric Laser Endomicroscopy's (VLE) Diagnostic Accuracy Validation Study: Impact on Clinical Management Study Enrolling by invitation NCT03951324

Search NIH Clinical Center for Intraductal Papilloma

Cochrane evidence based reviews: papilloma, intraductal

Genetic Tests for Intraductal Papilloma

Anatomical Context for Intraductal Papilloma

MalaCards organs/tissues related to Intraductal Papilloma:

42
Salivary Gland, Brain, Myeloid, Lymph Node, Spinal Cord, Cerebellum, Breast

Publications for Intraductal Papilloma

Articles related to Intraductal Papilloma:

(show top 50) (show all 117)
# Title Authors Year
1
Intraductal papilloma of the male breast: a case report and review of the literature. ( 30788101 )
2019
2
Intraductal papilloma of the breast - management. ( 30860277 )
2019
3
Mammographic and ultrasound findings in poroid hidradenoma of the breast mimicking intraductal papilloma and papillary carcinoma: A case report. ( 29924021 )
2018
4
Benign Intraductal Papilloma without Atypia on Core Needle Biopsy Has a Low Rate of Upgrading to Malignancy after Excision. ( 29628987 )
2018
5
Management of intraductal papilloma without atypia of the breast diagnosed on core biopsy: Size and sampling matter. ( 29687535 )
2018
6
Intraductal papilloma arising from the accessory parotid gland: A case report and literature review. ( 29768362 )
2018
7
Rare case of male breast intraductal papilloma progressing to invasive ductal carcinoma: A radiologic-pathologic correlation. ( 30073044 )
2018
8
Use of immunohistochemical analysis of CK5/6, CK14, and CK34betaE12 in the differential diagnosis of solid papillary carcinoma in situ from intraductal papilloma with usual ductal hyperplasia of the breast. ( 30455948 )
2018
9
Intraductal Papilloma Without Atypia on Image- Guided Breast Biopsy: Upgrade Rates to Carcinoma at Surgical Excision. ( 30498423 )
2018
10
Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor. ( 28648934 )
2017
11
Intraductal papilloma of the breast in an 11-year-old male patient: a case report. ( 28353086 )
2017
12
The Management Strategy of Benign Solitary Intraductal Papilloma on Breast Core Biopsy. ( 28438672 )
2017
13
Primary Osteosarcoma of the Breast Arising in an Intraductal Papilloma. ( 28713607 )
2017
14
Challenging Atypical Breast Lesions Including Flat Epithelial Atypia, Radial Scar, and Intraductal Papilloma. ( 28766216 )
2017
15
Immunocytochemical analysis of p63 and 34βE12 in fine needle aspiration cytology specimens for breast lesions: a potentially useful discriminatory marker between intraductal papilloma and ductal carcinoma in situ. ( 25810244 )
2016
16
Floor of Mouth Mass. Intraductal papilloma. ( 26583524 )
2016
17
Intraductal papilloma of the male breast. ( 26860828 )
2016
18
Intraductal Papilloma with Benign Pathology on Breast Core Biopsy: To Excise or Not? ( 26960929 )
2016
19
Apocrine Metaplasia in Intraductal Papilloma with Foci of DCIS: A Friend or Foe? ( 27499780 )
2016
20
MRI characteristics of intraductal papilloma. ( 24696194 )
2015
21
The significance of combined CK5/6 and p63 immunohistochemistry in predicting the risks of subsequent carcinoma development in intraductal papilloma of the breast. ( 25572436 )
2015
22
Exuberant squamous metaplasia in an intraductal papilloma of breast. ( 25583984 )
2015
23
A Case of Intraductal Papilloma of the Breast With High 18F-FDG Uptake on PET/CT. ( 26164173 )
2015
24
A prolapsed intraductal papilloma: a case report. ( 28058341 )
2015
25
Diagnosis of a Nonpalpable Intraductal Papilloma without Radiological Abnormality by Nipple Discharge Smear Examination: A Case Report. ( 24737934 )
2014
26
Intraductal papilloma in an axillary lymph node of a patient with human immunodeficiency virus: a case report and review of the literature. ( 24884898 )
2014
27
Concurrent fibroadenoma and intraductal papilloma - A recurring complex lesion in a premenarcheal girl. ( 23218483 )
2013
28
Mammotome biopsy in diagnosing and treatment of intraductal papilloma of the breast. ( 23640929 )
2013
29
Intraductal papilloma: atypical presentation. ( 23762648 )
2013
30
Combined evaluation of CK5/6, ER, p63, and MUC3 for distinguishing breast intraductal papilloma from ductal carcinoma in situ. ( 22612506 )
2012
31
Intraductal papilloma of the breast: A case report. ( 23396758 )
2012
32
Is CD56 a specific and reliable neuroendocrine marker for discriminating between endocrine/neuroendocrine ductal carcinoma in situ and intraductal papilloma of the breast? ( 21166944 )
2011
33
MRI features of intraductal papilloma of the breast: sheep in wolf's clothing? ( 21498361 )
2011
34
Glucose transporter expression of intraductal papilloma of the breast detected by fluorodeoxyglucose positron emission tomography. ( 21519997 )
2011
35
Enlarging unilateral breast mass in an adolescent male: an unusual presentation of intraductal papilloma. ( 21616226 )
2011
36
Intraductal papilloma of the breast in association with preoncogenic gene of breast cancer. ( 23569749 )
2011
37
Evaluation of CD56 and CD57 immunostainings for discrimination between endocrine ductal carcinoma in situ and intraductal papilloma. ( 20518901 )
2010
38
Intraductal papilloma of ectopic breast tissue in axillary lymph node of a patient with a previous intraductal papilloma of ipsilateral breast: a case report and review of the literature. ( 20222992 )
2010
39
External herniation of a subareolar intraductal papilloma: a rare, yet beneficial, complication of conventional ductography. ( 19913136 )
2009
40
"Signet-ring" cell invasive lobular carcinoma of the breast - accidental finding associated with intraductal papilloma: a case report. ( 19200374 )
2009
41
Carcinoma in a solitary intraductal papilloma of the breast. ( 19261097 )
2009
42
Excision is indicated for intraductal papilloma of the breast diagnosed on core needle biopsy. ( 19402174 )
2009
43
Intraductal papilloma arising from sublingual minor salivary gland: case report and immunohistochemical study. ( 19426904 )
2009
44
A potential diagnostic pitfall in aspiration cytology in intraductal papilloma of the parotid gland. ( 19697742 )
2009
45
Ultrasound-guided vacuum-assisted breast biopsy system for diagnosis and minimally invasive excision of intraductal papilloma without nipple discharge. ( 19777298 )
2009
46
Complicated solitary intraductal papilloma of the breast. ( 17971167 )
2008
47
Intraoral intraductal papilloma: a case report. ( 18201187 )
2008
48
Benign epithelial proliferations in axillary lymph nodes with ipsilateral breast in situ ductal carcinoma and intraductal papilloma of the breast. ( 18439159 )
2008
49
Intraductal carcinoma arising in intraductal papilloma in an axillary lymph node: review of the literature and proposed theories of evolution. ( 19061295 )
2008
50
A case of solitary intraductal papilloma of the breast coexisting with ductal carcinoma in situ (DCIS). ( 27278180 )
2007

Variations for Intraductal Papilloma

Expression for Intraductal Papilloma

Search GEO for disease gene expression data for Intraductal Papilloma.

Pathways for Intraductal Papilloma

Pathways related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
9.74 IDH1 IDH2

GO Terms for Intraductal Papilloma

Cellular components related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 CD44 IDH1 IDH2 KRT5 MYH11
2 cytosol GO:0005829 9.23 CD44 IDH1 IDH2 KRT5 MYH11 PGR

Biological processes related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.32 IDH1 IDH2
2 2-oxoglutarate metabolic process GO:0006103 9.26 IDH1 IDH2
3 NADP metabolic process GO:0006739 9.16 IDH1 IDH2
4 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
5 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 9.26 IDH1 IDH2
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH1 IDH2
3 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
4 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Intraductal Papilloma

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75 UMLS via Orphanet
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