MCID: INT016
MIFTS: 35

Intraductal Papilloma

Categories: Cancer diseases

Aliases & Classifications for Intraductal Papilloma

MalaCards integrated aliases for Intraductal Papilloma:

Name: Intraductal Papilloma 12 15
Papilloma, Intraductal 44 70
Papilloma Intraductal 54
Ductal Papilloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1627
MeSH 44 D018300
NCIt 50 C3785
SNOMED-CT 67 5244003
UMLS 70 C0206713

Summaries for Intraductal Papilloma

MalaCards based summary : Intraductal Papilloma, also known as papilloma, intraductal, is related to papilloma and in situ carcinoma. An important gene associated with Intraductal Papilloma is TP63 (Tumor Protein P63), and among its related pathways/superpathways are Estrogen signaling pathway (KEGG) and Signaling by ERBB4. Affiliated tissues include breast, salivary gland and lung, and related phenotypes are homeostasis/metabolism and cellular

Wikipedia : 73 Intraductal papillomas of the breast are benign lesions with an incidence of approximately 2-3% in... more...

Related Diseases for Intraductal Papilloma

Diseases related to Intraductal Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 papilloma 31.0 TP63 KRT7 KRT5 KRT14 ERBB2
2 in situ carcinoma 30.5 PGR KRT5 KRT14 ESR1 ERBB2
3 benign breast phyllodes tumor 30.4 TP63 PGR
4 hidradenoma 30.3 KRT7 KRT5
5 hypertrophy of breast 30.3 PGR ESR1 ERBB2
6 gynecomastia 30.3 PGR ESR1 ERBB2
7 breast disease 30.3 PGR KRT5 ESR1 ERBB2
8 comedo carcinoma 30.1 PGR ESR1 ERBB2
9 lobular neoplasia 30.1 PGR KRT5 ESR1 ERBB2
10 papillary carcinoma 30.1 TP63 PGR KRT7 ESR1 ERBB2
11 ductal carcinoma in situ 30.1 PGR MYH11 KRT5 KRT14 ESR1 ERBB2
12 breast fibroadenoma 30.0 TP63 PGR KRT14 ESR1 ERBB2
13 papillary adenocarcinoma 29.9 PGR KRT7 ERBB2
14 cystadenocarcinoma 29.8 PGR KRT7 ERBB2
15 breast metaplastic carcinoma 29.0 PGR KRT7 KRT5 KRT14 ESR1 ERBB2
16 breast duct papilloma 11.3
17 squamous cell papilloma 11.0
18 calcifying aponeurotic fibroma 10.4 PGR FN1
19 basaloid lung carcinoma 10.3 PGR KRT5
20 pregnancy adenoma 10.3 PGR KRT5
21 breast cystic hypersecretory carcinoma 10.3 KRT5 ERBB2
22 vulva basal cell carcinoma 10.3 KRT5 ERBB2
23 scirrhous adenocarcinoma 10.3 PGR ERBB2
24 breast squamous cell carcinoma 10.3 KRT5 ERBB2
25 apocrine adenosis of breast 10.3 PGR ERBB2
26 polymorphous low-grade adenocarcinoma 10.3 TP63 MYH11
27 luminal breast carcinoma b 10.3 PGR ERBB2
28 bartholin's gland adenoma 10.3 PGR ESR1
29 uterine corpus adenosarcoma 10.3 PGR ESR1
30 bartholin's gland benign neoplasm 10.3 PGR ESR1
31 chronic tympanitis 10.3 PGR ESR1
32 vestibular gland benign neoplasm 10.3 PGR ESR1
33 granulomatous endometritis 10.3 PGR ESR1
34 vulvar syringoma 10.3 PGR ESR1
35 lung leiomyoma 10.3 PGR ESR1
36 breast adenomyoepithelioma 10.3 KRT5 KRT14
37 adult type testicular granulosa cell tumor 10.3 PGR ESR1
38 liver leiomyoma 10.3 PGR ESR1
39 ameloblastic carcinoma 10.3 TP63 KRT14
40 intravenous leiomyomatosis 10.3 PGR ESR1
41 intracranial meningioma 10.3 PGR ESR1
42 bizarre leiomyoma 10.3 PGR ESR1
43 triple-receptor negative breast cancer 10.3 PGR ERBB2
44 prostate stromal sarcoma 10.2 PGR ESR1
45 breast papillomatosis 10.2 PGR ERBB2
46 micronodular basal cell carcinoma 10.2 KRT5 KRT14
47 breast myoepithelial neoplasm 10.2 KRT5 KRT14
48 glycogen-rich clear cell breast carcinoma 10.2 PGR KRT14
49 laryngeal mucoepidermoid carcinoma 10.2 KRT14 ERBB2
50 pinguecula 10.2 TP63 KRT14

Graphical network of the top 20 diseases related to Intraductal Papilloma:



Diseases related to Intraductal Papilloma

Symptoms & Phenotypes for Intraductal Papilloma

MGI Mouse Phenotypes related to Intraductal Papilloma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 CD44 ERBB2 ESR1 FN1 KRT14 KRT7
2 cellular MP:0005384 10.18 CD44 ERBB2 ESR1 FN1 KRT14 KRT7
3 cardiovascular system MP:0005385 10.15 CD44 ERBB2 ESR1 FN1 MFSD1 MYH11
4 digestive/alimentary MP:0005381 10.06 CD44 ERBB2 ESR1 KRT14 KRT5 MYH11
5 integument MP:0010771 10.06 CD44 ERBB2 ESR1 FN1 KRT14 KRT5
6 mortality/aging MP:0010768 10.06 CD44 ERBB2 ESR1 FN1 KRT14 KRT5
7 limbs/digits/tail MP:0005371 9.91 CD44 ERBB2 ESR1 FN1 KRT5 PGR
8 muscle MP:0005369 9.86 CD44 ERBB2 ESR1 FN1 MYH11 PGR
9 neoplasm MP:0002006 9.76 CD44 ERBB2 ESR1 FN1 KRT14 MFSD1
10 normal MP:0002873 9.5 CD44 ERBB2 ESR1 FN1 PGR PRKG1
11 reproductive system MP:0005389 9.32 CD44 ERBB2 ESR1 FN1 KRT14 MFSD1

Drugs & Therapeutics for Intraductal Papilloma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or DCIS in Patients Diagnosed With Intraductal Papilloma Without Atypia or Flat Epithelial Atypia by Core Needle Biopsy Recruiting NCT02489617
2 Feasibility and Therapeutic Efficacy of Ductoscopic Papilloma Extraction in Patients With Pathologic Nipple Discharge Active, not recruiting NCT01901562

Search NIH Clinical Center for Intraductal Papilloma

Cochrane evidence based reviews: papilloma, intraductal

Genetic Tests for Intraductal Papilloma

Anatomical Context for Intraductal Papilloma

MalaCards organs/tissues related to Intraductal Papilloma:

40
Breast, Salivary Gland, Lung, Ovary, Liver, Skin, Prostate

Publications for Intraductal Papilloma

Articles related to Intraductal Papilloma:

(show top 50) (show all 426)
# Title Authors PMID Year
1
Double immunostaining with p63 and high-molecular-weight cytokeratins distinguishes borderline papillary lesions of the breast. 54 61
17295644 2007
2
Clonal analysis of solitary intraductal papilloma of the breast by means of polymerase chain reaction. 61 54
7911274 1994
3
Upgrade rate of intraductal papilloma diagnosed on core needle biopsy in a single institution. 61
33159966 2021
4
Diagnostic value of sialyl-Tn immunocytochemistry in breast cancer presenting with pathological nipple discharge. 61
33605547 2021
5
Intraductal papilloma: An unusual presentation. 61
33374036 2021
6
Using the Superb Microvascular Imaging Method in the Distinction of Intraductal Papilloma and Duct Ectasia With Secretion. 61
32681668 2021
7
Classical Lobular Carcinoma In Situ Arising From an Intraductal Papilloma of the Breast: A Case Report. 61
33403884 2021
8
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy. 61
33106592 2021
9
Evaluating the usefulness of breast strain elastography for intraductal lesions. 61
33389371 2021
10
Papillary neoplasms of the breast-reviewing the spectrum. 61
33462367 2021
11
Use of fiberoductoscopy for the management of pathological nipple discharge: ten years follow up of a single center in China. 61
33447554 2020
12
Pathology of breast papillary neoplasms: Community hospital experience. 61
32920473 2020
13
Large breast lump with bloody nipple discharge: benign intraductal papilloma. 61
33148555 2020
14
A retrospective observational study of intraductal breast papilloma and its coexisting lesions: A real-world experience. 61
32822113 2020
15
Spectrum of Papillary Breast Lesions According to World Health Organization Classification of Papillary Neoplasms of Breast. 61
33214954 2020
16
The Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In Situ in Patients with Intraductal Papilloma without Atypia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 034). 61
33047246 2020
17
Risk factors of breast intraductal lesions in patients without pathological nipple discharge. 61
32832081 2020
18
Clear cell papillary neoplasm of the breast with MAML2 gene rearrangement: Clear cell hidradenoma or low-grade mucoepidermoid carcinoma? 61
32853960 2020
19
Mixed Invasive Apocrine Papillary/Micropapillary Carcinoma of the Breast: Another Brick in the Triple-Negative Wall. 61
32909476 2020
20
Upgrade rate of intraductal papilloma without atypia on breast core needle biopsy: A clinical, radiological and pathological correlation study. 61
32007236 2020
21
A rare case of intraductal papilloma with atypical ductal hyperplasia in a male breast: A pathological diagnosis. 61
33354154 2020
22
Intraductal Papilloma Arising From the Minor Salivary Glands of the Larynx: A Case Report. 61
32744904 2020
23
Benign breast papilloma: Is surgical excision necessary? 61
31612568 2020
24
Assessment and management of B3 breast lesions with atypia: a focused review. 61
31566023 2020
25
Histopathological evaluation of minor salivary gland papillary-cystic tumours: focus on genetic alterations in sialadenoma papilliferum and intraductal papillary mucinous neoplasm. 61
31505033 2020
26
A Rare Case of Intraductal Papilloma Arising from Minor Salivary Gland in the Floor of the Mouth. 61
32908761 2020
27
Can we see what is invisible? The role of MRI in the evaluation and management of patients with pathological nipple discharge. 61
31352554 2019
28
Treatment and Outcome of 341 Papillary Breast Lesions. 61
31209512 2019
29
Variability in the Management Recommendations Given for High-risk Breast Lesions Detected on Image-guided Core Needle Biopsy at U.S. Academic Institutions. 61
30075881 2019
30
Ultrasound-guided 7-gauge vacuum-assisted core biopsy: Could it be sufficient for the diagnosis and treatment of intraductal papilloma? 61
31131512 2019
31
Retrospective statistical analysis on the diagnostic value of ductography based on lesion pathology in patients presenting with nipple discharge. 61
31087380 2019
32
[Value of shear wave elastrography image classification in the diagnosis of breast masses]. 61
31357843 2019
33
[Comparison of modeling effects of two different 7, 12-dimethylbenz[a] anthracene induced breast cancer models in tree shrew]. 61
31137167 2019
34
A Novel Animal Model of Induced Breast Precancerous Lesion in Tree Shrew. 61
30674757 2019
35
Value of Magnetic Resonance Imaging Texture Analysis in the Differential Diagnosis of Benign and Malignant Breast Tumors. 61
30961778 2019
36
Intraductal papilloma of the male breast: a case report and review of the literature. 61
30788101 2019
37
Intraductal papilloma of the breast - management. 61
30860277 2019
38
Discrimination of breast cancer from benign tumours using Raman spectroscopy. 61
30763392 2019
39
[A Case Report of Breast Cancer Followed Up as Intraductal Papilloma]. 61
30765656 2019
40
Underestimation of breast cancer in intraductal papillomas treated with vacuum-assisted core needle biopsy. 61
30950000 2019
41
Is human papillomavirus associated with breast cancer or papilloma presenting with pathologic nipple discharge? 61
30785026 2019
42
Ultrasound-guided percutaneous microwave ablation of central intraductal papilloma: a prospective pilot study. 61
31179781 2019
43
Nipple discharge: The state of the art. 61
33178912 2019
44
[A Case of Neuroendocrine Carcinoma with Long-Term Abnormal Nipple Discharge]. 61
30692504 2018
45
Diagnosis of an extremely rare pleomorphic adenoma of the breast with core needle biopsy: A case report. 61
30510762 2018
46
A case of giant complicated intraductal papilloma of breast on MRI and literature review. 61
32729233 2018
47
Intraductal Papilloma Without Atypia on Image- Guided Breast Biopsy: Upgrade Rates to Carcinoma at Surgical Excision. 61
30498423 2018
48
Management of intraductal papilloma without atypia of the breast diagnosed on core biopsy: Size and sampling matter. 61
29687535 2018
49
Solid papillary carcinoma with reverse polarity of the breast harbors specific morphologic, immunohistochemical and molecular profile in comparison with other benign or malignant papillary lesions of the breast: a comparative study of 9 additional cases. 61
29785016 2018
50
Intraductal Papillary Mucinous Neoplasms of Minor Salivary Glands With AKT1 p.Glu17Lys Mutation. 61
29738361 2018

Variations for Intraductal Papilloma

Expression for Intraductal Papilloma

Search GEO for disease gene expression data for Intraductal Papilloma.

Pathways for Intraductal Papilloma

Pathways related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.57 PGR KRT14 ESR1
2
Show member pathways
11.37 PGR ESR1 ERBB2
3 11.24 FN1 ESR1 ERBB2 CD44
4
Show member pathways
11.17 KRT7 KRT5 KRT14

GO Terms for Intraductal Papilloma

Cellular components related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 8.8 KRT7 KRT5 KRT14

Biological processes related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.5 KRT7 KRT5 KRT14
2 epidermis development GO:0008544 9.43 TP63 KRT5 KRT14
3 hemidesmosome assembly GO:0031581 9.16 KRT5 KRT14
4 epithelial cell development GO:0002064 8.96 TP63 ESR1
5 intracellular steroid hormone receptor signaling pathway GO:0030518 8.62 PGR ESR1

Sources for Intraductal Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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