MCID: INT049
MIFTS: 25

Intrahepatic Bile Duct Adenoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Intrahepatic Bile Duct Adenoma

MalaCards integrated aliases for Intrahepatic Bile Duct Adenoma:

Name: Intrahepatic Bile Duct Adenoma 12 15 73
Adenoma of the Intrahepatic Bile Duct 12
Adenoma of Intrahepatic Bile Duct 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5437
NCIt 50 C7126
UMLS 73 C1331535

Summaries for Intrahepatic Bile Duct Adenoma

MalaCards based summary : Intrahepatic Bile Duct Adenoma, also known as adenoma of the intrahepatic bile duct, is related to adenoma and malignant struma ovarii. An important gene associated with Intrahepatic Bile Duct Adenoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Intrahepatic Bile Duct Adenoma

Diseases related to Intrahepatic Bile Duct Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 adenoma 10.5
2 malignant struma ovarii 10.2 AFP KRT19
3 hepatitis 10.2
4 anal gland adenocarcinoma 10.1 KRT19 KRT7
5 proliferating trichilemmal cyst 10.1 KRT19 KRT7
6 anus adenocarcinoma 10.1 KRT19 KRT7
7 ovarian germ cell cancer 10.1 AFP KRT7
8 cutaneous adenocystic carcinoma 10.1 KRT19 KRT7
9 bile duct cystadenocarcinoma 10.1 AFP KRT7
10 eccrine adenocarcinoma 10.1 KRT19 KRT7
11 intratubular embryonal carcinoma 10.1 AFP KRT7
12 bladder carcinoma in situ 10.1 KRT19 KRT7
13 malignant leydig cell tumor 10.1 KRT19 KRT7
14 corneal abscess 10.1 KRT19 KRT7
15 anal canal adenocarcinoma 10.1 KRT19 KRT7
16 choriocarcinoma of the testis 10.1 AFP KRT7
17 adenomatoid tumor 10.1 AFP KRT7
18 seminal vesicle tumor 10.1 AFP KRT7
19 renal pelvis carcinoma 10.1 KRT19 KRT7
20 chondroid lipoma 10.1 KRT19 KRT7
21 sertoli-leydig cell tumor 10.1 AFP KRT7
22 malignant biphasic mesothelioma 10.1 AFP KRT7
23 mucinous tubular and spindle renal cell carcinoma 10.0 KRT19 KRT7
24 ovarian endodermal sinus tumor 10.0 AFP KRT7
25 biliary papillomatosis 10.0 KRT19 KRT7
26 lipoadenoma 10.0 KRT19 KRT7
27 immune system organ benign neoplasm 10.0 KRT19 KRT7
28 thymus lipoma 10.0 KRT19 KRT7
29 ovarian primitive germ cell tumor 10.0 AFP KRT7
30 cystadenofibroma 10.0 AFP KRT7
31 renal cell carcinoma, nonpapillary 10.0
32 hepatitis b 10.0
33 endodermal sinus tumor 10.0 AFP KRT7
34 pericardium cancer 10.0 KRT19 KRT7
35 intraneural perineurioma 10.0 KRT19 KRT7
36 acinar cell carcinoma 10.0 AFP KRT7
37 pericardial mesothelioma 10.0 KRT19 KRT7
38 germ cell and embryonal cancer 10.0 AFP KRT7
39 white sponge nevus 1 9.9 KRT19 KRT7
40 sex cord-gonadal stromal tumor 9.9 AFP KRT7
41 primary cutaneous amyloidosis 9.9 KRT19 KRT7
42 polycystic liver disease 1 with or without kidney cysts 9.9 KRT19 KRT7
43 bile duct carcinoma 9.9 KRT19 KRT7
44 sarcoma, synovial 9.9 KRT19 KRT7
45 teratoma 9.8 AFP KRT7
46 chordoma 9.8 KRT19 KRT7
47 papillary carcinoma 9.8 KRT19 KRT7
48 hepatoblastoma 9.8 AFP KRT7
49 neuroendocrine tumor 9.7 KRT19 KRT7
50 adenoid cystic carcinoma 9.7 KRT19 KRT7

Graphical network of the top 20 diseases related to Intrahepatic Bile Duct Adenoma:



Diseases related to Intrahepatic Bile Duct Adenoma

Symptoms & Phenotypes for Intrahepatic Bile Duct Adenoma

GenomeRNAi Phenotypes related to Intrahepatic Bile Duct Adenoma according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.81 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.81 KRT19
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.81 KRT19
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.81 AFP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.81 AFP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.81 AFP KRT19
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.81 KRT19
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.81 AFP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.56 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.56 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.56 KRT7
12 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.56 KRT7 AFP
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.56 AFP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.56 AFP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.56 KRT7
16 Reduced mammosphere formation GR00396-S 8.8 KRT7 AFP GART

Drugs & Therapeutics for Intrahepatic Bile Duct Adenoma

Search Clinical Trials , NIH Clinical Center for Intrahepatic Bile Duct Adenoma

Genetic Tests for Intrahepatic Bile Duct Adenoma

Anatomical Context for Intrahepatic Bile Duct Adenoma

MalaCards organs/tissues related to Intrahepatic Bile Duct Adenoma:

41
Liver

Publications for Intrahepatic Bile Duct Adenoma

Articles related to Intrahepatic Bile Duct Adenoma:

(show all 11)
# Title Authors Year
1
Intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and review of literature. ( 26191317 )
2015
2
Magnetic Resonance Imaging Findings of Intrahepatic Bile Duct Adenoma: A Report of 4 Cases. ( 26248149 )
2015
3
Intrahepatic bile duct adenoma in a patient with chronic hepatitis B accompanied by elevation of alpha-fetoprotein. ( 26770929 )
2015
4
RE: Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. ( 24843248 )
2014
5
Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. ( 24043970 )
2013
6
Intrahepatic bile duct adenoma mimicking hepatic metastasis: case report and review of the literature. ( 23666160 )
2013
7
Ultrasonography of intrahepatic bile duct adenoma with renal cell carcinoma: correlation with pathology. ( 27277244 )
2013
8
Intrahepatic bile duct adenoma with oncocytic features. ( 22891770 )
2013
9
A case of very large intrahepatic bile duct adenoma followed for 7 years. ( 22574289 )
2012
10
Imaging findings of intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and literature review. ( 20808701 )
2010
11
Radiologic features of intrahepatic bile duct adenoma: a look at the surface of the liver. ( 10524847 )
1999

Variations for Intrahepatic Bile Duct Adenoma

Cosmic variations for Intrahepatic Bile Duct Adenoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM520 KRAS biliary tract,bile duct,other,adenoma c.35G>T p.G12V 12:25245350-25245350 8
2 COSM521 KRAS biliary tract,bile duct,other,adenoma c.35G>A p.G12D 12:25245350-25245350 8

Expression for Intrahepatic Bile Duct Adenoma

Search GEO for disease gene expression data for Intrahepatic Bile Duct Adenoma.

Pathways for Intrahepatic Bile Duct Adenoma

Pathways related to Intrahepatic Bile Duct Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.08 AFP KRT19
2
Show member pathways
10.66 KRT19 KRT7

GO Terms for Intrahepatic Bile Duct Adenoma

Cellular components related to Intrahepatic Bile Duct Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.62 KRT19 KRT7

Biological processes related to Intrahepatic Bile Duct Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 8.96 KRT19 KRT7
2 cornification GO:0070268 8.62 KRT19 KRT7

Sources for Intrahepatic Bile Duct Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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