MCID: INT049
MIFTS: 32

Intrahepatic Bile Duct Adenoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Intrahepatic Bile Duct Adenoma

MalaCards integrated aliases for Intrahepatic Bile Duct Adenoma:

Name: Intrahepatic Bile Duct Adenoma 12 15 70
Adenoma of the Intrahepatic Bile Duct 12
Adenoma of Intrahepatic Bile Duct 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5437
NCIt 50 C7126
UMLS 70 C1331535

Summaries for Intrahepatic Bile Duct Adenoma

MalaCards based summary : Intrahepatic Bile Duct Adenoma, also known as adenoma of the intrahepatic bile duct, is related to bile duct adenoma and adenoma. An important gene associated with Intrahepatic Bile Duct Adenoma is KRT19 (Keratin 19), and among its related pathways/superpathways are Developmental Biology and PI3K-Akt signaling pathway. Affiliated tissues include liver, breast and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Intrahepatic Bile Duct Adenoma

Diseases related to Intrahepatic Bile Duct Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 412)
# Related Disease Score Top Affiliating Genes
1 bile duct adenoma 31.2 TP53 NCAM1 KRT7 KRT20 KRT19
2 adenoma 30.4 TP53 KRT7 KRT20 CTNNB1 CHGA
3 hepatoblastoma 29.7 TP53 KRT7 KRT19 HNF1A CTNNB1 AFP
4 renal cell carcinoma, nonpapillary 29.6 TP53 MME KRT7 KRT20 KRT19 HNF1A
5 bile duct cancer 29.2 TP53 NCAM1 KRT7 KRT19 GPT CTNNB1
6 gastric cancer 28.4 TP53 PRDM2 NOTCH3 NOTCH2 KRT20 KRT19
7 gestational ovarian choriocarcinoma 10.4 CEACAM5 AFP
8 proliferating trichilemmal cyst 10.4 KRT7 KRT19
9 leukoplakia of penis 10.4 KRT7 CEACAM5
10 rete testis neoplasm 10.4 KRT7 AFP
11 liver lipoma 10.4 CEACAM5 AFP
12 rete testis adenocarcinoma 10.4 KRT7 AFP
13 bladder benign neoplasm 10.4 KRT7 KRT20
14 gallbladder leiomyosarcoma 10.4 KRT19 AFP
15 ureter adenocarcinoma 10.4 KRT7 CEACAM5
16 mucinous adenofibroma 10.4 KRT7 CEACAM5
17 immature teratoma of ovary 10.4 CEACAM5 AFP
18 atrophic vulva 10.4 KRT7 KRT20
19 intrahepatic gall duct cancer 10.4 KRT7 KRT19
20 malignant acrospiroma 10.4 KRT7 CEACAM5
21 anal paget's disease 10.4 KRT7 CEACAM5
22 rectum neuroendocrine neoplasm 10.4 KRT7 AFP
23 urachal adenocarcinoma 10.4 CEACAM5 AFP
24 cutaneous mucoepidermoid carcinoma 10.4 KRT7 CEACAM5
25 external ear carcinoma 10.4 KRT7 CEACAM5
26 liver inflammatory pseudotumor 10.4 CEACAM5 AFP
27 vulval paget's disease 10.4 KRT7 CEACAM5
28 ovarian primitive germ cell tumor 10.4 KRT7 AFP
29 rectum signet ring adenocarcinoma 10.4 CEACAM5 AFP
30 ovarian endodermal sinus tumor 10.4 KRT7 AFP
31 thymus adenocarcinoma 10.4 KRT20 CEACAM5
32 eccrine adenocarcinoma 10.4 KRT7 CEACAM5
33 eyelid carcinoma 10.4 KRT7 KRT20
34 dermoid cyst of ovary 10.4 CEACAM5 AFP
35 morpheaform basal cell carcinoma 10.4 KRT20 KRT19
36 acinar cell cystadenocarcinoma 10.4 KRT19 CHGA
37 adult type testicular granulosa cell tumor 10.4 NCAM1 AFP
38 auditory system benign neoplasm 10.4 KRT7 CHGA
39 vaginal glandular tumor 10.4 CHGA CEACAM5
40 jejunal neoplasm 10.4 KRT7 KRT20
41 jejunal cancer 10.4 KRT7 KRT20
42 papillary squamous carcinoma 10.4 KRT7 CEACAM5
43 adenoid basal cell carcinoma 10.4 KRT7 CEACAM5
44 mucoepidermoid esophageal carcinoma 10.4 TP53 CEACAM5
45 eyelid benign neoplasm 10.4 KRT20 CHGA
46 middle ear adenoma 10.4 KRT7 CHGA
47 primary hepatic neuroendocrine carcinoma 10.4 GPT CHGA
48 ureter transitional cell carcinoma 10.4 NCAM1 CHGA
49 ovarian seromucinous carcinoma 10.4 TP53 KRT7
50 ovarian germ cell teratoma 10.4 KRT7 KRT19 AFP

Graphical network of the top 20 diseases related to Intrahepatic Bile Duct Adenoma:



Diseases related to Intrahepatic Bile Duct Adenoma

Symptoms & Phenotypes for Intrahepatic Bile Duct Adenoma

GenomeRNAi Phenotypes related to Intrahepatic Bile Duct Adenoma according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.77 NOTCH2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.77 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.77 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.77 NOTCH2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.77 NOTCH2 TP53
6 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.77 TP53
7 Increased shRNA abundance (Z-score > 2) GR00366-A-184 9.77 TP53
8 Increased shRNA abundance (Z-score > 2) GR00366-A-187 9.77 NOTCH2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.77 HNF1A NOTCH2 TP53
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.77 TP53
11 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.77 NOTCH2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-20 9.77 TP53
13 Increased shRNA abundance (Z-score > 2) GR00366-A-211 9.77 NOTCH2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-212 9.77 HNF1A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.77 HNF1A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-28 9.77 HNF1A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.77 HNF1A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.77 TP53
19 Increased shRNA abundance (Z-score > 2) GR00366-A-38 9.77 HNF1A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.77 NOTCH2 TP53
21 Increased shRNA abundance (Z-score > 2) GR00366-A-62 9.77 TP53
22 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.77 HNF1A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.77 HNF1A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.77 EGLN1

MGI Mouse Phenotypes related to Intrahepatic Bile Duct Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 CTNNB1 EGLN1 HNF1A ITGA5 ITGAV KRT19
2 cardiovascular system MP:0005385 10.2 CHGA CTNNB1 EGLN1 ITGA5 ITGAV KLK3
3 mortality/aging MP:0010768 10.13 AFP CHGA CTNNB1 EGLN1 HNF1A ITGA5
4 endocrine/exocrine gland MP:0005379 10.06 AFP CHGA CTNNB1 HNF1A ITGAV KRT19
5 liver/biliary system MP:0005370 10.02 AFP CTNNB1 EGLN1 HNF1A KRT19 MME
6 muscle MP:0005369 9.91 CHGA CTNNB1 EGLN1 HNF1A ITGAV KLK3
7 neoplasm MP:0002006 9.76 AFP CTNNB1 ITGAV KRT19 NOTCH2 NOTCH3
8 nervous system MP:0003631 9.7 CHGA CTNNB1 EGLN1 ITGA5 ITGAV KRT19
9 renal/urinary system MP:0005367 9.28 CHGA CTNNB1 EGLN1 HNF1A ITGAV KRT7

Drugs & Therapeutics for Intrahepatic Bile Duct Adenoma

Search Clinical Trials , NIH Clinical Center for Intrahepatic Bile Duct Adenoma

Genetic Tests for Intrahepatic Bile Duct Adenoma

Anatomical Context for Intrahepatic Bile Duct Adenoma

MalaCards organs/tissues related to Intrahepatic Bile Duct Adenoma:

40
Liver, Breast, Lung, Ovary, Appendix, Colon, Kidney

Publications for Intrahepatic Bile Duct Adenoma

Articles related to Intrahepatic Bile Duct Adenoma:

(show all 18)
# Title Authors PMID Year
1
Hepatic nodules with arterial phase hyperenhancement and washout on enhanced computed tomography/magnetic resonance imaging: how to avoid pitfalls. 61
32377756 2020
2
Pediatric intrahepatic bile duct adenoma - rare liver tumor: A case report. 61
31798791 2019
3
Intrahepatic bile duct adenoma in a patient with gastric cancer. 61
31149539 2019
4
Intrahepatic bile duct adenoma in a patient with chronic hepatitis B accompanied by elevation of alpha-fetoprotein. 61
26770929 2015
5
Magnetic Resonance Imaging Findings of Intrahepatic Bile Duct Adenoma: A Report of 4 Cases. 61
26248149 2015
6
Intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and review of literature. 61
26191317 2015
7
RE: Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. 61
24843248 2014
8
Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. 61
24043970 2013
9
Ultrasonography of intrahepatic bile duct adenoma with renal cell carcinoma: correlation with pathology. 61
27277244 2013
10
Intrahepatic bile duct adenoma with oncocytic features. 61
22891770 2013
11
Intrahepatic bile duct adenoma mimicking hepatic metastasis: case report and review of the literature. 61
23666160 2013
12
A case of very large intrahepatic bile duct adenoma followed for 7 years. 61
22574289 2012
13
Imaging findings of intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and literature review. 61
20808701 2010
14
[Intrahepatic bile duct adenoma-induced segmentary hepatolithiasis]. 61
19439274 2009
15
[A case of intrahepatic bile duct adenoma]. 61
16444984 2006
16
Radiologic features of intrahepatic bile duct adenoma: a look at the surface of the liver. 61
10524847 1999
17
Non-neoplastic nodular lesions in the liver. 61
8563930 1995
18
Clinical experience of intrahepatic cholangiocarcinoma associated with hepatolithiasis. 61
2838667 1988

Variations for Intrahepatic Bile Duct Adenoma

Expression for Intrahepatic Bile Duct Adenoma

Search GEO for disease gene expression data for Intrahepatic Bile Duct Adenoma.

Pathways for Intrahepatic Bile Duct Adenoma

GO Terms for Intrahepatic Bile Duct Adenoma

Cellular components related to Intrahepatic Bile Duct Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.17 NOTCH3 NOTCH2 NCAM1 MME ITGAV ITGA5

Biological processes related to Intrahepatic Bile Duct Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 9.5 NCAM1 ITGAV ITGA5
2 placenta development GO:0001890 9.33 NOTCH2 MME HNF1A
3 regulation of developmental process GO:0050793 9.26 NOTCH3 NOTCH2
4 viral process GO:0016032 9.17 TP53 NCAM1 KRT7 KRT19 ITGAV ITGA5
5 regulation of angiogenesis GO:0045765 9.13 ITGA5 EGLN1 CTNNB1

Molecular functions related to Intrahepatic Bile Duct Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.8 NCAM1 ITGAV ITGA5

Sources for Intrahepatic Bile Duct Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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