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MCID: INT039
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Intrahepatic Biliary Papillomatosis

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Intrahepatic Biliary Papillomatosis

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MalaCards integrated aliases for Intrahepatic Biliary Papillomatosis:

Name: Intrahepatic Biliary Papillomatosis 12 15
Intrahepatic Bile Duct Papillary Neoplasm 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Liver diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:8230
NCIt 49 C7125
UMLS 71 C1334258
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Summaries for Intrahepatic Biliary Papillomatosis

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MalaCards based summary : Intrahepatic Biliary Papillomatosis, also known as intrahepatic bile duct papillary neoplasm, is related to biliary papillomatosis and adenoma. An important gene associated with Intrahepatic Biliary Papillomatosis is MUC5B (Mucin 5B, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are O-linked glycosylation and Diseases of glycosylation. Affiliated tissues include liver, ovary and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Intrahepatic Biliary Papillomatosis

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Diseases related to Intrahepatic Biliary Papillomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 biliary papillomatosis 31.1 MUC5AC MUC1
2 adenoma 30.0 MUC5AC MUC1 KRAS
3 bile duct cysts 29.9 KRAS AFP
4 intrahepatic cholangiocarcinoma 28.7 MUC5AC MUC1 KRAS AFP
5 cholangiocarcinoma 28.7 MUC5AC MUC1 KRAS AFP
6 papilloma 10.7
7 cholangitis 10.4
8 lung mucoepidermoid carcinoma 10.2 MUC5B MUC5AC
9 status asthmaticus 10.2 MUC5B MUC5AC
10 middle ear disease 10.1 MUC5B MUC5AC
11 caroli disease, isolated 10.1
12 caroli disease 10.1
13 obstructive jaundice 10.1
14 autoimmune hepatitis 10.1
15 liver cirrhosis 10.1
16 extrahepatic biliary papillomatosis 10.1
17 rare tumor 10.1
18 ovarian mucinous neoplasm 10.1 MUC5AC KRAS
19 duodenum adenocarcinoma 10.1 MUC5AC KRAS
20 colloid carcinoma of the pancreas 10.1 MUC5B MUC1
21 cystadenocarcinoma 10.1 MUC5AC MUC1
22 mucoepidermoid carcinoma 10.1 MUC5AC MUC1
23 bronchiolo-alveolar adenocarcinoma 10.0 MUC5AC KRAS
24 urinary bladder villous adenoma 10.0 MUC5AC MUC1
25 mucinous intrahepatic cholangiocarcinoma 10.0 MUC5AC MUC1
26 solid adenocarcinoma with mucin production 10.0 MUC5AC MUC1
27 glandular cystitis 10.0 MUC5AC MUC1
28 pancreatic mucinous cystadenoma 10.0 MUC5AC MUC1
29 nonspecific interstitial pneumonia 10.0 MUC5B MUC1
30 limbal stem cell deficiency 10.0 MUC5AC MUC1
31 colorectal cancer, hereditary nonpolyposis, type 8 10.0 MUC5AC MUC1
32 complete androgen insensitivity syndrome 10.0 MUC5AC MUC1
33 androgen insensitivity syndrome 10.0 MUC5AC MUC1
34 gastric diffuse adenocarcinoma 10.0 MUC5AC MUC1
35 meconium ileus 10.0 MUC5AC MUC1
36 paget disease, extramammary 10.0 MUC5AC MUC1
37 ampulla of vater adenocarcinoma 10.0 MUC5AC MUC1
38 syringocystadenoma papilliferum 10.0 MUC1 KRAS
39 endocervical adenocarcinoma 10.0 MUC5AC MUC1
40 otitis media 10.0 MUC5B MUC5AC
41 endosalpingiosis 10.0 MUC1 KRAS
42 pancreatic ductal carcinoma 10.0 MUC5AC MUC1
43 cholecystitis 9.9 MUC5AC MUC1
44 dry eye syndrome 9.9 MUC5AC MUC1
45 ovarian cystadenocarcinoma 9.9 MUC1 KRAS
46 papillary adenocarcinoma 9.9 MUC1 KRAS
47 endometrial adenocarcinoma 9.9 MUC1 KRAS
48 adenosquamous carcinoma 9.9 MUC1 KRAS
49 idiopathic interstitial pneumonia 9.9 MUC5B MUC1
50 small cell carcinoma 9.9 MUC1 KRAS

Graphical network of the top 20 diseases related to Intrahepatic Biliary Papillomatosis:



Diseases related to Intrahepatic Biliary Papillomatosis
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Symptoms & Phenotypes for Intrahepatic Biliary Papillomatosis

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GenomeRNAi Phenotypes related to Intrahepatic Biliary Papillomatosis according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.53 KRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.53 AFP KRAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.53 KRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.53 KRAS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.53 KRAS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.53 KRAS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.53 KRAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.53 KRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.53 KRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.53 AFP
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.53 KRAS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.53 AFP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.53 KRAS
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.53 AFP
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.53 AFP
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Drugs & Therapeutics for Intrahepatic Biliary Papillomatosis

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Search Clinical Trials , NIH Clinical Center for Intrahepatic Biliary Papillomatosis

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Genetic Tests for Intrahepatic Biliary Papillomatosis

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Anatomical Context for Intrahepatic Biliary Papillomatosis

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MalaCards organs/tissues related to Intrahepatic Biliary Papillomatosis:

40
Liver, Ovary, Lung, Pancreas, Appendix, Eye, Small Intestine
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Publications for Intrahepatic Biliary Papillomatosis

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Articles related to Intrahepatic Biliary Papillomatosis:

(show all 14)
# Title Authors PMID Year
1
Intrahepatic biliary papillomatosis associated with malignant transformation: report of two cases and review of the literature. 61
26885145 2015
2
Mucin-producing intrahepatic biliary papillomatosis. 61
20740348 2010
3
Malignant potential of intrahepatic biliary papillomatosis: a case report and review of the literature. 61
17026772 2006
4
Long-term survival after isolated liver transplantation for intrahepatic biliary papillomatosis. 61
16441776 2006
5
[Intrahepatic biliary papillomatosis: a case report]. 61
16060190 2005
6
[A case of intrahepatic biliary papillomatosis associated with autoimmune hepatitis]. 61
14639931 2003
7
Malignant intrahepatic biliary papillomatosis associated with viral C cirrhosis. 61
11860318 2002
8
Fine-needle aspiration cytologic diagnosis of intrahepatic biliary papillomatosis (intraductal papillary tumor): report of three cases and comparative study with cholangiocarcinoma. 61
10790236 2000
9
[Intrahepatic biliary papillomatosis]. 61
8749510 1995
10
Intrahepatic biliary papillomatosis arising in nonobstructive intrahepatic biliary dilatations confined to the hepatic left lobe. 61
1928050 1991
11
[Intrahepatic biliary papillomatosis]. 61
3574730 1987
12
Intrahepatic biliary papillomatosis. 61
6722467 1984
13
Intrahepatic biliary papillomatosis. 61
6689977 1984
14
Intrahepatic biliary papillomatosis. 61
583123 1979
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Variations for Intrahepatic Biliary Papillomatosis

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Cosmic variations for Intrahepatic Biliary Papillomatosis:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM134615012 biliary tract,bile duct,other,papillomatosis c.34G>T p.G12C 12:25245351-25245351 0
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Expression for Intrahepatic Biliary Papillomatosis

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Search GEO for disease gene expression data for Intrahepatic Biliary Papillomatosis.
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Pathways for Intrahepatic Biliary Papillomatosis

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Pathways related to Intrahepatic Biliary Papillomatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
O-linked glycosylation 65
Show member pathways
 11.7 MUC5B MUC5AC MUC1
2
Diseases of glycosylation 65
Show member pathways
 11.5 MUC5B MUC5AC MUC1
3
CLEC7A (Dectin-1) signaling 65
Show member pathways
 11.34 MUC5B MUC5AC MUC1 KRAS
4
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) 65
Show member pathways
 11.17 MUC5B MUC5AC MUC1
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GO Terms for Intrahepatic Biliary Papillomatosis

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Cellular components related to Intrahepatic Biliary Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC5B MUC5AC MUC1

Biological processes related to Intrahepatic Biliary Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 O-glycan processing GO:0016266 9.13 MUC5B MUC5AC MUC1
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.92 MUC5B MUC5AC MUC1 KRAS
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Sources for Intrahepatic Biliary Papillomatosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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