MCID: INT099
MIFTS: 53

Intrahepatic Cholestasis of Pregnancy

Categories: Fetal diseases, Gastrointestinal diseases, Genetic diseases, Liver diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Intrahepatic Cholestasis of Pregnancy

MalaCards integrated aliases for Intrahepatic Cholestasis of Pregnancy:

Name: Intrahepatic Cholestasis of Pregnancy 12 54 26 60 38 45 15 17
Recurrent Intrahepatic Cholestasis of Pregnancy 12 54 26 60
Gravidic Intrahepatic Cholestasis 12 54 60
Pregnancy-Related Cholestasis 54 26 60
Pregnancy Related Cholestasis 12 54
Icp 12 54
Familial Recurrent Intrahepatic Cholestasis of Pregnancy 54
Familial Intrahepatic Cholestasis of Pregnancy 54
Cholestasis, Intrahepatic of Pregnancy 54
Obstetric Cholestasis 26
Ricp 54

Characteristics:

Orphanet epidemiological data:

60
intrahepatic cholestasis of pregnancy
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:0070227
KEGG 38 H02193
MeSH 45 C535932
MESH via Orphanet 46 C535932
ICD10 via Orphanet 35 O26.6
Orphanet 60 ORPHA69665

Summaries for Intrahepatic Cholestasis of Pregnancy

NIH Rare Diseases : 54 Intrahepatic cholestasis of pregnancy (ICP) is a disorder of the liver that occurs in women during pregnancy. Cholestasis is a condition that impairs the release of bile (a digestive juice) from liver cells. The bile then builds up in the liver, impairing liver function. Symptoms typically become apparent in the third trimester of pregnancy and can include severe itching (pruritus). Occasionally, the skin and the whites of the eyes can have a yellow appearance (jaundice). ICP is additionally associated with risks to the developing baby such as premature delivery and stillbirth. The cause of ICP is largely unknown, although approximately 15% of cases are caused by mutations in either the ABCB11 or ABCB4 genes. Mutations within the ABCB11 and ABCB4 genes are inherited in an autosomal dominant manner. Symptoms of ICP are typically limited to pregnancy. Bile flow returns to normal after delivery and the signs and symptoms of the condition disappear, however, they can return during later pregnancies.

MalaCards based summary : Intrahepatic Cholestasis of Pregnancy, also known as recurrent intrahepatic cholestasis of pregnancy, is related to cholestasis, progressive familial intrahepatic, 1 and cholestasis. An important gene associated with Intrahepatic Cholestasis of Pregnancy is NR1H4 (Nuclear Receptor Subfamily 1 Group H Member 4), and among its related pathways/superpathways are Bile secretion and Synthesis of bile acids and bile salts. The drugs Ursodeoxycholic acid and Metformin have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and eye, and related phenotypes are no effect and homeostasis/metabolism

Disease Ontology : 12 An intrahepatic cholestasis characterized by reversible cholestasis typically occurring in the second or third trimester of pregnancy, elevated serum aminotransferases and bile acid level and resolution of symptoms by 2 to 3 weeks after delivery.

Genetics Home Reference : 26 Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the liver, impairing liver function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestasis of pregnancy usually becomes apparent in the third trimester of pregnancy. Bile flow returns to normal after delivery of the baby, and the signs and symptoms of the condition disappear. However, they can return during later pregnancies.

Wikipedia : 77 Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of... more...

Related Diseases for Intrahepatic Cholestasis of Pregnancy

Diseases in the Intrahepatic Cholestasis of Pregnancy family:

Cholestasis, Intrahepatic, of Pregnancy, 1 Cholestasis, Intrahepatic, of Pregnancy 3

Diseases related to Intrahepatic Cholestasis of Pregnancy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 cholestasis, progressive familial intrahepatic, 1 32.4 ABCB11 ABCB4 ATP8B1 NR1H4
2 cholestasis 31.5 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 GPT
3 cholestasis, progressive familial intrahepatic, 3 30.4 ABCB11 ABCB4 ATP8B1
4 progressive familial intrahepatic cholestasis 30.2 ABCB11 ABCB4 ABCC2 ATP8B1 NR1H4 SLCO1B3
5 liver disease 30.1 ABCB11 ABCB4 ATP8B1 GPT NR1H4
6 cholestasis, intrahepatic, of pregnancy, 1 12.4
7 cholestasis, intrahepatic, of pregnancy 3 12.3
8 multiple sclerosis 10.8
9 hepatitis 10.4
10 hydrocephalus 10.4
11 head injury 10.4
12 tetralogy of fallot 10.4
13 atp8b1 deficiency 10.3 ABCB11 ATP8B1 NR1H4
14 cholestasis, progressive familial intrahepatic, 4 10.3 ABCB11 ABCB4 ATP8B1
15 pre-eclampsia 10.3
16 hydrocephalus, normal-pressure 10.3
17 intracranial hypertension 10.3
18 alagille syndrome 1 10.3 ABCB11 ABCB4 ATP8B1
19 hepatitis c 10.3
20 spondyloenchondrodysplasia 10.3
21 cholestasis, progressive familial intrahepatic, 2 10.3 ABCB11 ABCB4 ATP8B1 NR1H4
22 cholestasis, progressive familial intrahepatic, 5 10.3 NR1H4 NR1I2 NR1I3
23 cholelithiasis 10.3 ABCB4 GPT NR1H4
24 congenital hydrocephalus 10.3
25 autosomal dominant non-syndromic intellectual disability 2 10.2 NR1I2 NR1I3
26 biliary atresia 10.2 ATP8B1 GPT NR1H4
27 intraocular pressure quantitative trait locus 10.2
28 cholangitis 10.2 ABCB11 ABCB4 GPBAR1 GPT
29 dubin-johnson syndrome 10.2
30 hypoxia 10.2
31 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.2
32 bilirubin metabolic disorder 10.2 ABCC2 GPT NR1I3
33 autosomal dominant non-syndromic intellectual disability 3 10.2 NR1I2 NR1I3
34 traumatic brain injury 10.2
35 extrahepatic cholestasis 10.2 ABCB4 ABCC2 ABCC3 GPT
36 cholangitis, primary sclerosing 10.2 ABCB4 GPBAR1 GPT NR1I2
37 retinoblastoma 10.2
38 retinitis pigmentosa 10.2
39 hyperbilirubinemia, rotor type 10.1 ABCC2 SLCO1B3
40 sclerosing cholangitis 10.1 ABCB11 ABCB4 GPBAR1 NR1H4 NR1I2
41 cholestasis, benign recurrent intrahepatic, 1 10.1
42 hepatitis c virus 10.1
43 gestational diabetes 10.1
44 eclampsia 10.1
45 viral hepatitis 10.1
46 fatty liver disease 10.1
47 triiodothyronine receptor auxiliary protein 10.1
48 cholestasis, benign recurrent intrahepatic, 2 10.1 ABCB11 ATP8B1
49 blood group, gerbich system 10.1
50 streptococcal group a invasive disease 10.1

Graphical network of the top 20 diseases related to Intrahepatic Cholestasis of Pregnancy:



Diseases related to Intrahepatic Cholestasis of Pregnancy

Symptoms & Phenotypes for Intrahepatic Cholestasis of Pregnancy

GenomeRNAi Phenotypes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 ABCB11 ABCB4 ABCC2 ABCC3 ADAMTS12 ATP8B1

MGI Mouse Phenotypes related to Intrahepatic Cholestasis of Pregnancy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.83 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 CRHR2
2 liver/biliary system MP:0005370 9.36 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 ESR2

Drugs & Therapeutics for Intrahepatic Cholestasis of Pregnancy

Drugs for Intrahepatic Cholestasis of Pregnancy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 3,Phase 2 128-13-2 31401
2
Metformin Approved Phase 2, Phase 3 657-24-9 14219 4091
3
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
4 Gastrointestinal Agents Phase 3,Phase 2
5 Cholagogues and Choleretics Phase 3,Phase 2
6 Liver Extracts Phase 2, Phase 3
7 Hypoglycemic Agents Phase 2, Phase 3
8 Vaccines Phase 2,Not Applicable
9
Sofosbuvir Approved 1190307-88-0 45375808
10
Velpatasvir Approved, Investigational 1377049-84-7 67683363
11 Estrogens
12 Hormones
13 Bile Acids and Salts
14 Antiviral Agents
15 Anti-Infective Agents
16 Antibodies Not Applicable
17 Immunoglobulins Not Applicable

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of Pregnancy Completed NCT01576458 Phase 3 ursodeoxycholic acid;Placebo
2 Metformin in Intrahepatic Cholestasis of Pregnancy Not yet recruiting NCT03056274 Phase 2, Phase 3 Metformin;Ursodeoxycholic Acid
3 Ursodeoxycholic Acid And Cholestasis Of Pregnancy Withdrawn NCT01226823 Phase 3 Ursodeoxycholic Acid;Placebo
4 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of the GlaxoSmithKline (GSK) Biologicals' Respiratory Syncytial Virus (RSV) Investigational Vaccine (GSK3003891A) in Healthy Pregnant Women and Infants Born to Vaccinated Mothers Withdrawn NCT03191383 Phase 2 Placebo (Formulation buffer S9b)
5 Serum Autotaxin Levels in Cholestasis of Pregnancy Unknown status NCT02480478
6 Il-17 Levels in Intrahepatic Cholestasis of Pregnancy Unknown status NCT01898832
7 Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis. Unknown status NCT02192177
8 P-wave Duration and Dispersion in Intrahepatic Cholestasis of Pregnancy Unknown status NCT01906827
9 ABCB4 Gene Mutations in Intrahepatic Cholestasis of Pregnancy and Controls Completed NCT00700232
10 Induction of Labor in Intrahepatic Cholestasis of Pregnancy Completed NCT01381939
11 Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women Completed NCT03154268
12 The Metabolic Profile in Intrahepatic Cholestasis of Pregnancy and Diabetes Mellitus Recruiting NCT01499524
13 Bile Acid Effects in Fetal Arrhythmia Study Recruiting NCT03519399
14 White Adipose Tissue in Pregnancy Study Recruiting NCT02495987
15 Transmission of Chronic Hepatitis C in Pregnancy Recruiting NCT03570112 SOF/VEL- sofosbuvir 400mg and velpatasvir 100mg
16 Liver Disease in Pregnancy Not yet recruiting NCT03834285
17 A Study of Outcomes and Events of Interest in Pregnant Women, Neonates and Infants and of RSV Surveillance Not yet recruiting NCT03614676 Not Applicable
18 The Best Timing of Delivery in Women With GDM Study Not yet recruiting NCT03928899 Not Applicable
19 The Use of Fish Oil Supplementation in Treatment of Intrahepatic Cholestasis of Pregnancy Withdrawn NCT01965054 Not Applicable

Search NIH Clinical Center for Intrahepatic Cholestasis of Pregnancy

Cochrane evidence based reviews: intrahepatic cholestasis of pregnancy

Genetic Tests for Intrahepatic Cholestasis of Pregnancy

Anatomical Context for Intrahepatic Cholestasis of Pregnancy

MalaCards organs/tissues related to Intrahepatic Cholestasis of Pregnancy:

42
Liver, Skin, Eye, Brain, Placenta, Testes, Heart

Publications for Intrahepatic Cholestasis of Pregnancy

Articles related to Intrahepatic Cholestasis of Pregnancy:

(show top 50) (show all 468)
# Title Authors Year
1
Relations of neuropeptide Y and heme oxygenase-1 expressions with fetal brain injury in rats with intrahepatic cholestasis of pregnancy. ( 31066785 )
2019
2
Association between bile salt export pump polymorphisms and intrahepatic cholestasis of pregnancy susceptibility: a meta-analysis of case-control studies. ( 30614300 )
2019
3
Adjuvant Use of Rifampin for Refractory Intrahepatic Cholestasis of Pregnancy. ( 30681532 )
2019
4
Inflammatory marker YKL-40 levels in intrahepatic cholestasis of pregnancy. ( 30688121 )
2019
5
Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy. ( 30697260 )
2019
6
Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. ( 30773280 )
2019
7
Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of inflammatory cytokines and fetal outcomes. ( 30936968 )
2019
8
Early Onset Intrahepatic Cholestasis of Pregnancy: Is Progesterone Supplementation to be Blamed For? ( 30956477 )
2019
9
Correlation of lipid peroxidation and ATP enzyme on erythrocyte membrane with fetal distress in the uterus in patients with intrahepatic cholestasis of pregnancy. ( 30964154 )
2019
10
Predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy. ( 31059115 )
2019
11
Thiopurine hepatotoxicity can mimic intrahepatic cholestasis of pregnancy. ( 31109900 )
2019
12
Biliary transporter gene mutations in severe intrahepatic cholestasis of pregnancy: Diagnostic and management implications. ( 29992621 )
2019
13
Waveform analysis of the fetal ECG in labor in patients with intrahepatic cholestasis of pregnancy. ( 30203501 )
2019
14
Is It Necessary to Perform the Pharmacological Interventions for Intrahepatic Cholestasis of Pregnancy? A Bayesian Network Meta-Analysis. ( 30357607 )
2019
15
Predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy with dichorionic diamniotic twin pregnancies. ( 29020816 )
2019
16
Diagnosis and prognosis of early-onset intrahepatic cholestasis of pregnancy: a prospective study. ( 29065754 )
2019
17
Treatment of intrahepatic cholestasis of pregnancy with ursodeoxycholic acid associated with improvement of fetal first-degree atrioventricular block. ( 29484735 )
2018
18
Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES). ( 30482254 )
2018
19
May circulating steroids reveal a predisposition to intrahepatic cholestasis of pregnancy in non-pregnant women? ( 30484676 )
2018
20
The Serum microRNA Profile of Intrahepatic Cholestasis of Pregnancy: Identification of Novel Noninvasive Biomarkers. ( 30485846 )
2018
21
Targeted metabolomics of sulfated bile acids in urine for the diagnosis and grading of intrahepatic cholestasis of pregnancy. ( 30591938 )
2018
22
Celastrol Attenuates Intrahepatic Cholestasis of Pregnancy by Inhibiting Matrix Metalloproteinases-2 and 9. ( 30596610 )
2018
23
The role of metabolic disorders in the pathogenesis of intrahepatic cholestasis of pregnancy. ( 30603668 )
2018
24
Lithocholic acid activates mTOR signaling inducing endoplasmic reticulum stress in placenta during intrahepatic cholestasis of pregnancy. ( 30605648 )
2018
25
Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy. ( 30830343 )
2018
26
Diagnostic and therapeutic profiles of serum bile acids in women with intrahepatic cholestasis of pregnancy-a pseudo-targeted metabolomics study. ( 29709452 )
2018
27
Role of ischemia-modified albumin in the evaluation of oxidative stress in intrahepatic cholestasis of pregnancy. ( 29739259 )
2018
28
Resveratrol regulates the silent information regulator 1-nuclear factor-κB signaling pathway in intrahepatic cholestasis of pregnancy. ( 29855113 )
2018
29
Assessment of circulating betatrophin levels in intrahepatic cholestasis of pregnancy. ( 29890866 )
2018
30
Intrahepatic cholestasis of pregnancy and associated causes of death: a cohort study with follow-up of 27-46 years. ( 29914448 )
2018
31
Effect of inducible nitric oxide synthase and neuropeptide Y in plasma and placentas from intrahepatic cholestasis of pregnancy. ( 29956420 )
2018
32
Low serum vitamin D level is associated with intrahepatic cholestasis of pregnancy. ( 29978524 )
2018
33
Perinatal outcomes in intrahepatic cholestasis of pregnancy with monochorionic diamniotic twin pregnancy. ( 29980184 )
2018
34
Could first- and second-trimester biochemical markers for Down syndrome have a role in predicting intrahepatic cholestasis of pregnancy? ( 30002703 )
2018
35
Magnesium sulphate can alleviate oxidative stress and reduce inflammatory cytokines in rat placenta of intrahepatic cholestasis of pregnancy model. ( 30039470 )
2018
36
The role of ABC transporters' gene polymorphism in the etiology of intrahepatic cholestasis of pregnancy. ( 30091450 )
2018
37
Novel compound heterozygous ABCC2 variants in patients with Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy. ( 30092126 )
2018
38
Adjuvant Use of Rifampin for Refractory Intrahepatic Cholestasis of Pregnancy. ( 30095766 )
2018
39
PPARγ provides anti-inflammatory and protective effects in intrahepatic cholestasis of pregnancy through NF-κB pathway. ( 30219229 )
2018
40
Linc02527 promoted autophagy in Intrahepatic cholestasis of pregnancy. ( 30250023 )
2018
41
Assessment of fetal left ventricular modified myocardial performance index and its prognostic significance for adverse perinatal outcome in intrahepatic cholestasis of pregnancy. ( 30309274 )
2018
42
Therapeutic plasma exchange as a novel treatment for severe intrahepatic cholestasis of pregnancy: Case series and mechanism of action. ( 30321466 )
2018
43
Intrahepatic cholestasis of pregnancy. ( 30372720 )
2018
44
Intrahepatic cholestasis of pregnancy: Review of six national and regional guidelines. ( 30396107 )
2018
45
Does ursodeoxycholic acid improve perinatal outcomes in women with intrahepatic cholestasis of pregnancy? ( 29419378 )
2018
46
Intrahepatic Cholestasis of Pregnancy: A Review of Diagnosis and Management. ( 29480924 )
2018
47
Impacts of different methods of conception on the perinatal outcome of intrahepatic cholestasis of pregnancy in twin pregnancies. ( 29507303 )
2018
48
Intrahepatic cholestasis of pregnancy: Shorter duration of labor? ( 29680685 )
2018
49
Expression and significance of dendritic cells and Th17/Treg in serum and placental tissues of patients with intrahepatic cholestasis of pregnancy. ( 28298162 )
2018
50
An alternative method for measuring oxidative stress in intrahepatic cholestasis of pregnancy: thiol/disulphide homeostasis. ( 28462673 )
2018

Variations for Intrahepatic Cholestasis of Pregnancy

Expression for Intrahepatic Cholestasis of Pregnancy

Search GEO for disease gene expression data for Intrahepatic Cholestasis of Pregnancy.

Pathways for Intrahepatic Cholestasis of Pregnancy

Pathways related to Intrahepatic Cholestasis of Pregnancy according to KEGG:

38
# Name Kegg Source Accession
1 Bile secretion hsa04976

Pathways related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.01 ABCB11 ABCC3 NR1H4 SLCO1A2 SLCO1B3
2
Show member pathways
11.89 ABCB11 ABCB4 ABCC2 SLCO1A2
3
Show member pathways
11.79 ABCB11 ABCC2 SLCO1A2 SLCO1B3
4
Show member pathways
11.71 ESR2 NR1H4 NR1I2 NR1I3
5 11.56 ABCB11 ABCB4 ABCC2 ABCC3 NR1H4 SLCO1A2
6
Show member pathways
11.51 ABCC2 NR1I2 NR1I3
7 11.16 ABCC2 ABCC3 NR1I3
8 10.95 ABCC2 ABCC3
9 10.86 ABCB11 ABCB4 NR1H4
10
Show member pathways
10.86 ABCC2 ABCC3 SLCO1A2 SLCO1B3
11 10.81 ABCC2 ABCC3
12 10.72 ABCC3 NR1I2
13 10.71 ABCB11 ABCB4 ABCC2 ABCC3 NR1H4 NR1I2
14 10.66 ABCB11 ABCC2 ABCC3 NR1H4 NR1I2 NR1I3
15 10.61 ABCC2 NR1I2 SLCO1B3
16 10.54 ABCC2 ABCC3
17 10.36 CRHR2 UCN

GO Terms for Intrahepatic Cholestasis of Pregnancy

Cellular components related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.56 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 CRHR2
2 RNA polymerase II transcription factor complex GO:0090575 9.33 NR1H4 NR1I2 NR1I3
3 intercellular canaliculus GO:0046581 8.8 ABCB11 ABCB4 ABCC2

Biological processes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.73 ABCB11 ABCB4 ABCC2 ABCC3 SLCO1A2 SLCO1B3
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.67 ESR2 NR1H4 NR1I2 NR1I3
3 steroid hormone mediated signaling pathway GO:0043401 9.58 NR1H4 NR1I2 NR1I3
4 phospholipid translocation GO:0045332 9.51 ABCB4 ATP8B1
5 intracellular receptor signaling pathway GO:0030522 9.5 NR1H4 NR1I2 NR1I3
6 sodium-independent organic anion transport GO:0043252 9.49 SLCO1A2 SLCO1B3
7 bile acid metabolic process GO:0008206 9.48 ATP8B1 NR1H4
8 organic anion transport GO:0015711 9.46 SLCO1A2 SLCO1B3
9 drug transmembrane transport GO:0006855 9.16 ABCC2 ATP8B1
10 xenobiotic transport GO:0042908 9.13 NR1I2
11 canalicular bile acid transport GO:0015722 9.13 ABCB11 ABCC2 ABCC3
12 bile acid and bile salt transport GO:0015721 9.1 ABCB11 ABCC3 ATP8B1 NR1H4 SLCO1A2 SLCO1B3

Molecular functions related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.83 ENPP2 NR1H4 NR1I2 NR1I3
2 transcription coactivator activity GO:0003713 9.8 ESR2 NR1H4 NR1I2 NR1I3
3 ATPase activity GO:0016887 9.76 ABCB11 ABCB4 ABCC2 ABCC3
4 transcription regulatory region sequence-specific DNA binding GO:0000976 9.61 NR1H4 NR1I2 NR1I3
5 nuclear receptor transcription coactivator activity GO:0030374 9.58 NR1H4 NR1I2 NR1I3
6 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.56 ABCB11 ABCB4 ABCC2 ABCC3
7 sodium-independent organic anion transmembrane transporter activity GO:0015347 9.51 SLCO1A2 SLCO1B3
8 bile acid transmembrane transporter activity GO:0015125 9.48 SLCO1A2 SLCO1B3
9 steroid hormone receptor activity GO:0003707 9.46 ESR2 NR1H4 NR1I2 NR1I3
10 bile acid receptor activity GO:0038181 9.37 GPBAR1 NR1H4
11 bile acid-exporting ATPase activity GO:0015432 9.32 ABCB11 ABCC3
12 nuclear receptor activity GO:0004879 9.26 ESR2 NR1H4 NR1I2 NR1I3
13 organic anion transmembrane transporter activity GO:0008514 8.92 ABCC2 ABCC3 SLCO1A2 SLCO1B3

Sources for Intrahepatic Cholestasis of Pregnancy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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