ICP
MCID: INT099
MIFTS: 59

Intrahepatic Cholestasis of Pregnancy (ICP)

Categories: Fetal diseases, Gastrointestinal diseases, Genetic diseases, Liver diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Intrahepatic Cholestasis of Pregnancy

MalaCards integrated aliases for Intrahepatic Cholestasis of Pregnancy:

Name: Intrahepatic Cholestasis of Pregnancy 12 12 54 26 60 38 45 15 17
Recurrent Intrahepatic Cholestasis of Pregnancy 12 54 26 60
Intrahepatic Cholestasis 12 30 6 15
Gravidic Intrahepatic Cholestasis 12 54 60
Pregnancy-Related Cholestasis 54 26 60
Pregnancy Related Cholestasis 12 54
Icp 12 54
Familial Recurrent Intrahepatic Cholestasis of Pregnancy 54
Familial Intrahepatic Cholestasis of Pregnancy 54
Cholestasis, Intrahepatic of Pregnancy 54
Cholestasis, Intrahepatic 45
Cholestasis Intrahepatic 56
Obstetric Cholestasis 26
Ricp 54

Characteristics:

Orphanet epidemiological data:

60
intrahepatic cholestasis of pregnancy
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:0070227 DOID:1852
KEGG 38 H02193
NCIt 51 C84400
SNOMED-CT 69 4637005
MESH via Orphanet 46 C535932
ICD10 via Orphanet 35 O26.6
Orphanet 60 ORPHA69665
UMLS 74 C0008372

Summaries for Intrahepatic Cholestasis of Pregnancy

NIH Rare Diseases : 54 Intrahepatic cholestasis of pregnancy (ICP) is a disorder of the liver that occurs in women during pregnancy. Cholestasis is a condition that impairs the release of bile (a digestive juice) from liver cells. The bile then builds up in the liver, impairing liver function. Symptoms typically become apparent in the third trimester of pregnancy and can include severe itching (pruritus). Occasionally, the skin and the whites of the eyes can have a yellow appearance (jaundice). ICP is additionally associated with risks to the developing baby such as premature delivery and stillbirth. The cause of ICP is largely unknown, although approximately 15% of cases are caused by mutations in either the ABCB11 or ABCB4 genes. Mutations within the ABCB11 and ABCB4 genes are inherited in an autosomal dominant manner. Symptoms of ICP are typically limited to pregnancy. Bile flow returns to normal after delivery and the signs and symptoms of the condition disappear, however, they can return during later pregnancies.

MalaCards based summary : Intrahepatic Cholestasis of Pregnancy, also known as recurrent intrahepatic cholestasis of pregnancy, is related to cholestasis, progressive familial intrahepatic, 3 and cholestasis, progressive familial intrahepatic, 2, and has symptoms including icterus and hepatocellular jaundice. An important gene associated with Intrahepatic Cholestasis of Pregnancy is ABCB11 (ATP Binding Cassette Subfamily B Member 11), and among its related pathways/superpathways are Bile secretion and Metabolism. The drugs Ursodeoxycholic acid and Metformin have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 An intrahepatic cholestasis characterized by reversible cholestasis typically occurring in the second or third trimester of pregnancy, elevated serum aminotransferases and bile acid level and resolution of symptoms by 2 to 3 weeks after delivery.

Genetics Home Reference : 26 Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the liver, impairing liver function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestasis of pregnancy usually becomes apparent in the third trimester of pregnancy. Bile flow returns to normal after delivery of the baby, and the signs and symptoms of the condition disappear. However, they can return during later pregnancies.

Wikipedia : 77 Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of... more...

Related Diseases for Intrahepatic Cholestasis of Pregnancy

Diseases in the Intrahepatic Cholestasis of Pregnancy family:

Cholestasis, Intrahepatic, of Pregnancy, 1 Cholestasis, Intrahepatic, of Pregnancy 3

Diseases related to Intrahepatic Cholestasis of Pregnancy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 207)
# Related Disease Score Top Affiliating Genes
1 cholestasis, progressive familial intrahepatic, 3 34.2 ABCB11 ABCB4 ATP8B1
2 cholestasis, progressive familial intrahepatic, 2 34.1 ABCB11 ABCB4 ATP8B1 NR1H4
3 cholestasis, progressive familial intrahepatic, 4 33.8 ABCB11 ABCB4 ATP8B1
4 cholestasis, benign recurrent intrahepatic, 2 33.7 ABCB11 ATP8B1
5 cholestasis, progressive familial intrahepatic, 5 33.6 NR1H4 NR1I2 NR1I3
6 atp8b1 deficiency 33.1 ABCB11 ATP8B1 NR1H4
7 cholestasis, progressive familial intrahepatic, 1 32.5 ABCB11 ABCB4 ATP8B1 NR1H4
8 cholestasis 31.4 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 GGT1
9 biliary atresia 30.9 ATP8B1 GPT NR1H4
10 alagille syndrome 1 30.9 ABCB11 ABCB4 ATP8B1
11 dubin-johnson syndrome 30.8 ABCC2 ABCC3 SLCO1B1
12 cholelithiasis 30.8 ABCB4 GPT NR1H4
13 progressive familial intrahepatic cholestasis 30.4 ABCB11 ABCB4 ABCC2 ATP8B1 NR1H4 SLCO1B1
14 cholangitis 30.4 ABCB11 ABCB4 GGT1 GPBAR1 GPT
15 bilirubin metabolic disorder 30.3 ABCC2 GGT1 GPT NR1I3 SLCO1B1
16 sclerosing cholangitis 30.3 ABCB11 ABCB4 GGT1 GPBAR1 NR1H4 NR1I2
17 extrahepatic cholestasis 30.2 ABCB4 ABCC2 ABCC3 GGT1 GPT
18 liver disease 30.0 ABCB11 ABCB4 ATP8B1 GGT1 GPT NR1H4
19 citrullinemia, type ii, neonatal-onset 12.4
20 cholestasis, intrahepatic, of pregnancy, 1 12.4
21 myo5b-related progressive familial intrahepatic cholestasis 12.2
22 cholestasis, intrahepatic, of pregnancy 3 12.1
23 bile acid synthesis defect, congenital, 4 12.0
24 bile acid synthesis defect, congenital, 1 12.0
25 citrullinemia, type ii, adult-onset 11.6
26 bile acid synthesis defect, congenital, 2 11.4
27 gilbert syndrome 11.2
28 arthrogryposis, renal dysfunction, and cholestasis 1 11.2
29 north american indian childhood cirrhosis 11.2
30 crigler-najjar syndrome, type ii 11.2
31 bile acid synthesis defect, congenital, 3 11.2
32 multiple sclerosis 10.8
33 hepatitis 10.4
34 amyloidosis 10.4
35 hydrocephalus 10.4
36 head injury 10.4
37 tetralogy of fallot 10.4
38 hyperbilirubinemia, rotor type 10.3 ABCC2 SLCO1B1 SLCO1B3
39 autosomal dominant non-syndromic intellectual disability 2 10.3 NR1I2 NR1I3
40 sickle cell disease 10.3
41 autosomal dominant non-syndromic intellectual disability 3 10.3 NR1I2 NR1I3
42 hydrocephalus, normal-pressure 10.3
43 intracranial hypertension 10.3
44 hepatitis c 10.3
45 brain injury 10.3
46 spondyloenchondrodysplasia 10.3
47 intraocular pressure quantitative trait locus 10.2
48 nodular lymphocyte predominant hodgkin lymphoma 10.2
49 pre-eclampsia 10.2
50 hypoxia 10.2

Graphical network of the top 20 diseases related to Intrahepatic Cholestasis of Pregnancy:



Diseases related to Intrahepatic Cholestasis of Pregnancy

Symptoms & Phenotypes for Intrahepatic Cholestasis of Pregnancy

UMLS symptoms related to Intrahepatic Cholestasis of Pregnancy:


icterus, hepatocellular jaundice

GenomeRNAi Phenotypes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

27 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.02 ABCC3
2 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.02 ABCC3 ERP29 GGT1 GPBAR1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.02 ERP29
4 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.02 GPBAR1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-136 10.02 GPBAR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.02 ABCC3 GGT1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.02 ABCC3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.02 ERP29
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.02 GGT1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.02 ABCC3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.02 ABCC3
12 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.02 ERP29
13 Increased shRNA abundance (Z-score > 2) GR00366-A-197 10.02 ERP29
14 Increased shRNA abundance (Z-score > 2) GR00366-A-208 10.02 ABCC3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-24 10.02 GPBAR1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-37 10.02 ERP29
17 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.02 GPBAR1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.02 GPBAR1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.02 GGT1
20 no effect GR00402-S-1 9.92 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 ENPP2

MGI Mouse Phenotypes related to Intrahepatic Cholestasis of Pregnancy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.83 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 ENPP2
2 liver/biliary system MP:0005370 9.36 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 GPBAR1

Drugs & Therapeutics for Intrahepatic Cholestasis of Pregnancy

Drugs for Intrahepatic Cholestasis of Pregnancy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 3,Phase 2 128-13-2 31401
2
Metformin Approved Phase 2, Phase 3 657-24-9 14219 4091
3
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
4 Cholagogues and Choleretics Phase 3,Phase 2
5 Gastrointestinal Agents Phase 3,Phase 2
6 Liver Extracts Phase 2, Phase 3
7 Hypoglycemic Agents Phase 2, Phase 3
8 Vaccines Phase 2
9 Immunologic Factors Phase 2
10
Velpatasvir Approved, Investigational 1377049-84-7 67683363
11
Sofosbuvir Approved 1190307-88-0 45375808
12 Omega 3 Fatty Acid Not Applicable
13 Estrogens
14 Hormones
15 Bile Acids and Salts
16 Anti-Infective Agents
17 Antiviral Agents

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Ursodeoxycholic Acid And Cholestasis Of Pregnancy Withdrawn NCT01226823 Phase 3 Ursodeoxycholic Acid;Placebo
2 Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of Pregnancy Completed NCT01576458 Phase 3 ursodeoxycholic acid;Placebo
3 Metformin in Intrahepatic Cholestasis of Pregnancy Not yet recruiting NCT03056274 Phase 2, Phase 3 Metformin;Ursodeoxycholic Acid
4 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of the GlaxoSmithKline (GSK) Biologicals' Respiratory Syncytial Virus (RSV) Investigational Vaccine (GSK3003891A) in Healthy Pregnant Women and Infants Born to Vaccinated Mothers Withdrawn NCT03191383 Phase 2 Placebo (Formulation buffer S9b)
5 Serum Autotaxin Levels in Cholestasis of Pregnancy Unknown status NCT02480478
6 Il-17 Levels in Intrahepatic Cholestasis of Pregnancy Unknown status NCT01898832
7 Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis. Unknown status NCT02192177
8 P-wave Duration and Dispersion in Intrahepatic Cholestasis of Pregnancy Unknown status NCT01906827
9 White Adipose Tissue in Pregnancy Study Unknown status NCT02495987
10 The Use of Fish Oil Supplementation in Treatment of Intrahepatic Cholestasis of Pregnancy Withdrawn NCT01965054 Not Applicable
11 ABCB4 Gene Mutations in Intrahepatic Cholestasis of Pregnancy and Controls Completed NCT00700232
12 The Metabolic Profile in Intrahepatic Cholestasis of Pregnancy and Diabetes Mellitus Recruiting NCT01499524
13 Induction of Labor in Intrahepatic Cholestasis of Pregnancy Completed NCT01381939
14 Bile Acid Effects in Fetal Arrhythmia Study Recruiting NCT03519399
15 Liver Disease in Pregnancy Not yet recruiting NCT03834285
16 Transmission of Chronic Hepatitis C in Pregnancy Recruiting NCT03570112 SOF/VEL- sofosbuvir 400mg and velpatasvir 100mg
17 Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women Completed NCT03154268

Search NIH Clinical Center for Intrahepatic Cholestasis of Pregnancy

Cochrane evidence based reviews: cholestasis, intrahepatic

Genetic Tests for Intrahepatic Cholestasis of Pregnancy

Genetic tests related to Intrahepatic Cholestasis of Pregnancy:

# Genetic test Affiliating Genes
1 Intrahepatic Cholestasis 30

Anatomical Context for Intrahepatic Cholestasis of Pregnancy

MalaCards organs/tissues related to Intrahepatic Cholestasis of Pregnancy:

42
Liver, Skin, Eye, Placenta, Testes, Heart, Smooth Muscle

Publications for Intrahepatic Cholestasis of Pregnancy

Articles related to Intrahepatic Cholestasis of Pregnancy:

(show top 50) (show all 460)
# Title Authors Year
1
Lithocholic acid activates mTOR signaling inducing endoplasmic reticulum stress in placenta during intrahepatic cholestasis of pregnancy. ( 30605648 )
2019
2
Association between bile salt export pump polymorphisms and intrahepatic cholestasis of pregnancy susceptibility: a meta-analysis of case-control studies. ( 30614300 )
2019
3
Adjuvant Use of Rifampin for Refractory Intrahepatic Cholestasis of Pregnancy. ( 30681532 )
2019
4
Inflammatory marker YKL-40 levels in intrahepatic cholestasis of pregnancy. ( 30688121 )
2019
5
Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy. ( 30697260 )
2019
6
Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. ( 30773280 )
2019
7
Predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy with dichorionic diamniotic twin pregnancies. ( 29020816 )
2019
8
Treatment of intrahepatic cholestasis of pregnancy with ursodeoxycholic acid associated with improvement of fetal first-degree atrioventricular block. ( 29484735 )
2018
9
Diagnostic and therapeutic profiles of serum bile acids in women with intrahepatic cholestasis of pregnancy-a pseudo-targeted metabolomics study. ( 29709452 )
2018
10
Intrahepatic cholestasis of pregnancy and associated causes of death: a cohort study with follow-up of 27-46A years. ( 29914448 )
2018
11
Effect of inducible nitric oxide synthase and neuropeptide Y in plasma and placentas from intrahepatic cholestasis of pregnancy. ( 29956420 )
2018
12
Impacts of different methods of conception on the perinatal outcome of intrahepatic cholestasis of pregnancy in twin pregnancies. ( 29507303 )
2018
13
Resveratrol Regulating SIRT1-NF-I_B Signal Pathway in Intrahepatic Cholestasis of Pregnancy. ( 29855113 )
2018
14
Assessment of circulating betatrophin levels in intrahepatic cholestasis of pregnancy. ( 29890866 )
2018
15
Perinatal outcomes in intrahepatic cholestasis of pregnancy with monochorionic diamniotic twin pregnancy. ( 29980184 )
2018
16
Does ursodeoxycholic acid improve perinatal outcomes in women with intrahepatic cholestasis of pregnancy? ( 29419378 )
2018
17
Low serum vitamin D level is associated with intrahepatic cholestasis of pregnancy. ( 29978524 )
2018
18
Intrahepatic cholestasis of pregnancy: Shorter duration of labor? ( 29680685 )
2018
19
Role of ischemia-modified albumin in the evaluation of oxidative stress in intrahepatic cholestasis of pregnancy. ( 29739259 )
2018
20
Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy. ( 30830343 )
2018
21
Magnesium sulphate can alleviate oxidative stress and reduce inflammatory cytokines in rat placenta of intrahepatic cholestasis of pregnancy model. ( 30039470 )
2018
22
The role of ABC transporters' gene polymorphism in the etiology of intrahepatic cholestasis of pregnancy. ( 30091450 )
2018
23
Novel compound heterozygous ABCC2 variants in patients with Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy. ( 30092126 )
2018
24
Adjuvant Use of Rifampin for Refractory Intrahepatic Cholestasis of Pregnancy. ( 30095766 )
2018
25
Waveform analysis of the fetal ECG in labor in patients with intrahepatic cholestasis of pregnancy. ( 30203501 )
2018
26
PPARγ provides anti-inflammatory and protective effects in intrahepatic cholestasis of pregnancy through NF-κB pathway. ( 30219229 )
2018
27
Linc02527 promoted autophagy in Intrahepatic cholestasis of pregnancy. ( 30250023 )
2018
28
Assessment of fetal left ventricular modified myocardial performance index and its prognostic significance for adverse perinatal outcome in intrahepatic cholestasis of pregnancy. ( 30309274 )
2018
29
Therapeutic plasma exchange as a novel treatment for severe intrahepatic cholestasis of pregnancy: Case series and mechanism of action. ( 30321466 )
2018
30
Is It Necessary to Perform the Pharmacological Interventions for Intrahepatic Cholestasis of Pregnancy? A Bayesian Network Meta-Analysis. ( 30357607 )
2018
31
Intrahepatic cholestasis of pregnancy. ( 30372720 )
2018
32
Intrahepatic cholestasis of pregnancy: Review of six national and regional guidelines. ( 30396107 )
2018
33
Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES). ( 30482254 )
2018
34
May circulating steroids reveal a predisposition to intrahepatic cholestasis of pregnancy in non-pregnant women? ( 30484676 )
2018
35
The Serum microRNA Profile of Intrahepatic Cholestasis of Pregnancy: Identification of Novel Noninvasive Biomarkers. ( 30485846 )
2018
36
Targeted metabolomics of sulfated bile acids in urine for the diagnosis and grading of intrahepatic cholestasis of pregnancy. ( 30591938 )
2018
37
Celastrol Attenuates Intrahepatic Cholestasis of Pregnancy by Inhibiting Matrix Metalloproteinases-2 and 9. ( 30596610 )
2018
38
The role of metabolic disorders in the pathogenesis of intrahepatic cholestasis of pregnancy. ( 30603668 )
2018
39
An alternative method for measuring oxidative stress in intrahepatic cholestasis of pregnancy: thiol/disulphide homeostasis. ( 28462673 )
2018
40
Intrahepatic Cholestasis of Pregnancy: A Review of Diagnosis and Management. ( 29480924 )
2018
41
Biliary transporter gene mutations in severe intrahepatic cholestasis of pregnancy: Diagnostic and management implications. ( 29992621 )
2018
42
Could first- and second-trimester biochemical markers for Down syndrome have a role in predicting intrahepatic cholestasis of pregnancy? ( 30002703 )
2018
43
Expression and significance of dendritic cells and Th17/Treg in serum and placental tissues of patients with intrahepatic cholestasis of pregnancy. ( 28298162 )
2018
44
An expanded role for heterozygous mutations of ABCB4, ABCB11, ATP8B1, ABCC2 and TJP2 in intrahepatic cholestasis of pregnancy. ( 28924228 )
2017
45
Correction to: Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy in a Sri Lankan family: a case report. ( 28982379 )
2017
46
Intrahepatic cholestasis of pregnancy or azithromycin-induced intrahepatic cholestasis: A case report. ( 29384912 )
2017
47
Can we predict severity of intrahepatic cholestasis of pregnancy using inflammatory markers? ( 29085705 )
2017
48
Maternal copeptin levels in intrahepatic cholestasis of pregnancy. ( 28552021 )
2017
49
A retrospective cohort review of intrahepatic cholestasis of pregnancy in a South Australian population. ( 28926728 )
2017
50
Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy in a Sri Lankan family: a case report. ( 28923092 )
2017

Variations for Intrahepatic Cholestasis of Pregnancy

ClinVar genetic disease variations for Intrahepatic Cholestasis of Pregnancy:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ABCB11 NM_003742.4(ABCB11): c.3148C> T (p.Arg1050Cys) single nucleotide variant Pathogenic rs72549398 GRCh37 Chromosome 2, 169788952: 169788952
2 ABCB11 NM_003742.4(ABCB11): c.3148C> T (p.Arg1050Cys) single nucleotide variant Pathogenic rs72549398 GRCh38 Chromosome 2, 168932442: 168932442

Expression for Intrahepatic Cholestasis of Pregnancy

Search GEO for disease gene expression data for Intrahepatic Cholestasis of Pregnancy.

Pathways for Intrahepatic Cholestasis of Pregnancy

Pathways related to Intrahepatic Cholestasis of Pregnancy according to KEGG:

38
# Name Kegg Source Accession
1 Bile secretion hsa04976

Pathways related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 ABCB11 ABCB4 ABCC3 ENPP2 GGT1 GPT
2
Show member pathways
13.22 ABCB4 ABCC2 ABCC3 ATP8B1 SLCO1A2 SLCO1B1
3
Show member pathways
12.04 ABCB11 ABCC3 NR1H4 SLCO1A2 SLCO1B1 SLCO1B3
4 11.94 ABCC2 ABCC3 GGT1
5
Show member pathways
11.92 ABCC2 ABCC3 SLCO1B1
6
Show member pathways
11.9 ABCB11 ABCB4 ABCC2 SLCO1A2 SLCO1B1
7
Show member pathways
11.82 ABCB11 ABCC2 SLCO1A2 SLCO1B1 SLCO1B3
8
Show member pathways
11.69 NR1H4 NR1I2 NR1I3
10
Show member pathways
11.49 ABCC2 NR1I2 NR1I3
11 11.42 ABCB11 ABCB4 ABCC2 ABCC3 NR1H4 SLCO1A2
12 11.24 ABCB11 ABCB4 ABCC2 ABCC3 NR1H4 NR1I2
13 11.16 ABCC2 ABCC3 NR1I3
14 10.96 ABCC2 ABCC3
15
Show member pathways
10.96 ABCC2 ABCC3 SLCO1A2 SLCO1B1 SLCO1B3
16 10.91 ABCB11 ABCB4 NR1H4
17 10.83 ABCC2 ABCC3
18 10.74 ABCC3 NR1I2
19 10.72 ABCC2 NR1I2 SLCO1B3
20 10.52 ABCC2 ABCC3
21 10.4 ABCB11 ABCC2 ABCC3 NR1H4 NR1I2 NR1I3

GO Terms for Intrahepatic Cholestasis of Pregnancy

Cellular components related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.61 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 SLC25A13
2 RNA polymerase II transcription factor complex GO:0090575 9.33 NR1H4 NR1I2 NR1I3
3 intercellular canaliculus GO:0046581 8.8 ABCB11 ABCB4 ABCC2
4 plasma membrane GO:0005886 10.1 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 ENPP2
5 integral component of membrane GO:0016021 10.07 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 ENPP2

Biological processes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.76 ABCB11 ABCB4 ABCC2 ABCC3 SLC25A13 SLCO1A2
2 steroid hormone mediated signaling pathway GO:0043401 9.61 NR1H4 NR1I2 NR1I3
3 intracellular receptor signaling pathway GO:0030522 9.58 NR1H4 NR1I2 NR1I3
4 phospholipid translocation GO:0045332 9.52 ABCB4 ATP8B1
5 bile acid metabolic process GO:0008206 9.51 ATP8B1 NR1H4
6 sodium-independent organic anion transport GO:0043252 9.5 SLCO1A2 SLCO1B1 SLCO1B3
7 ATP hydrolysis coupled anion transmembrane transport GO:0099133 9.49 ABCC2 ABCC3
8 thyroid hormone transport GO:0070327 9.48 ABCC2 SLCO1B1
9 organic anion transport GO:0015711 9.43 SLCO1A2 SLCO1B1 SLCO1B3
10 drug transmembrane transport GO:0006855 9.37 ABCC2 ATP8B1
11 bile acid and bile salt transport GO:0015721 9.17 ABCB11 ABCC3 ATP8B1 NR1H4 SLCO1A2 SLCO1B1
12 xenobiotic transport GO:0042908 9.16 NR1I2
13 canalicular bile acid transport GO:0015722 9.13 ABCB11 ABCC2 ABCC3

Molecular functions related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.84 ENPP2 NR1H4 NR1I2 NR1I3
2 ATPase activity GO:0016887 9.81 ABCB11 ABCB4 ABCC2 ABCC3
3 transmembrane transporter activity GO:0022857 9.7 ABCC2 ABCC3 SLC25A13
4 transcription regulatory region sequence-specific DNA binding GO:0000976 9.67 NR1H4 NR1I2 NR1I3
5 nuclear receptor transcription coactivator activity GO:0030374 9.63 NR1H4 NR1I2 NR1I3
6 steroid hormone receptor activity GO:0003707 9.61 NR1H4 NR1I2 NR1I3
7 nuclear receptor activity GO:0004879 9.58 NR1H4 NR1I2 NR1I3
8 ATPase-coupled anion transmembrane transporter activity GO:0043225 9.48 ABCC2 ABCC3
9 sodium-independent organic anion transmembrane transporter activity GO:0015347 9.43 SLCO1A2 SLCO1B1 SLCO1B3
10 bile acid receptor activity GO:0038181 9.37 GPBAR1 NR1H4
11 bile acid transmembrane transporter activity GO:0015125 9.33 SLCO1A2 SLCO1B1 SLCO1B3
12 bile acid-exporting ATPase activity GO:0015432 9.32 ABCB11 ABCC3
13 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.26 ABCB11 ABCB4 ABCC2 ABCC3
14 organic anion transmembrane transporter activity GO:0008514 8.92 ABCC2 ABCC3 SLCO1A2 SLCO1B3

Sources for Intrahepatic Cholestasis of Pregnancy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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