ICP
MCID: INT099
MIFTS: 60

Intrahepatic Cholestasis of Pregnancy (ICP)

Categories: Endocrine diseases, Fetal diseases, Gastrointestinal diseases, Genetic diseases, Liver diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Intrahepatic Cholestasis of Pregnancy

MalaCards integrated aliases for Intrahepatic Cholestasis of Pregnancy:

Name: Intrahepatic Cholestasis of Pregnancy 12 12 53 25 59 37 44 15
Recurrent Intrahepatic Cholestasis of Pregnancy 12 53 25 59
Intrahepatic Cholestasis 12 29 6 15
Gravidic Intrahepatic Cholestasis 12 53 59
Pregnancy-Related Cholestasis 53 25 59
Pregnancy Related Cholestasis 12 53
Icp 12 53
Familial Recurrent Intrahepatic Cholestasis of Pregnancy 53
Familial Intrahepatic Cholestasis of Pregnancy 53
Cholestasis, Intrahepatic of Pregnancy 53
Cholestasis, Intrahepatic 44
Cholestasis Intrahepatic 55
Obstetric Cholestasis 25
Ricp 53

Characteristics:

Orphanet epidemiological data:

59
intrahepatic cholestasis of pregnancy
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:0070227 DOID:1852
NCIt 50 C84400
SNOMED-CT 68 4637005
Orphanet 59 ORPHA69665
MESH via Orphanet 45 C535932
ICD10 via Orphanet 34 O26.6
KEGG 37 H02193
UMLS 73 C0008372

Summaries for Intrahepatic Cholestasis of Pregnancy

NIH Rare Diseases : 53 Intrahepatic cholestasis of pregnancy (ICP) is a disorder of the liver that occurs in women during pregnancy. Cholestasis is a condition that impairs the release of bile (a digestive juice) from liver cells. The bile then builds up in the liver, impairing liver function. Symptoms typically become apparent in the third trimester of pregnancy and can include severe itching (pruritus). Occasionally, the skin and the whites of the eyes can have a yellow appearance (jaundice). ICP is additionally associated with risks to the developing baby such as premature delivery and stillbirth. The cause of ICP is largely unknown, although approximately 15% of cases are caused by mutations in either the ABCB11 or ABCB4 genes. Mutations within the ABCB11 and ABCB4 genes are inherited in an autosomal dominant manner. Symptoms of ICP are typically limited to pregnancy. Bile flow returns to normal after delivery and the signs and symptoms of the condition disappear, however, they can return during later pregnancies.

MalaCards based summary : Intrahepatic Cholestasis of Pregnancy, also known as recurrent intrahepatic cholestasis of pregnancy, is related to cholestasis, progressive familial intrahepatic, 3 and cholestasis, progressive familial intrahepatic, 2, and has symptoms including icterus and hepatocellular jaundice. An important gene associated with Intrahepatic Cholestasis of Pregnancy is ABCB4 (ATP Binding Cassette Subfamily B Member 4), and among its related pathways/superpathways are Bile secretion and Metabolism. The drugs Ursodeoxycholic acid and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and eye, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 An intrahepatic cholestasis characterized by reversible cholestasis typically occurring in the second or third trimester of pregnancy, elevated serum aminotransferases and bile acid level and resolution of symptoms by 2 to 3 weeks after delivery.

Genetics Home Reference : 25 Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the liver, impairing liver function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestasis of pregnancy usually becomes apparent in the third trimester of pregnancy. Bile flow returns to normal after delivery of the baby, and the signs and symptoms of the condition disappear. However, they can return during later pregnancies.

Wikipedia : 76 Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of... more...

Related Diseases for Intrahepatic Cholestasis of Pregnancy

Diseases in the Intrahepatic Cholestasis of Pregnancy family:

Cholestasis, Intrahepatic, of Pregnancy, 1 Cholestasis, Intrahepatic, of Pregnancy 3

Diseases related to Intrahepatic Cholestasis of Pregnancy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 cholestasis, progressive familial intrahepatic, 3 34.0 ABCB11 ABCB4 ATP8B1
2 cholestasis, progressive familial intrahepatic, 2 33.9 ABCB11 ABCB4 ATP8B1 NR1H4
3 cholestasis, benign recurrent intrahepatic, 2 33.6 ABCB11 ATP8B1
4 cholestasis, progressive familial intrahepatic, 4 33.5 ABCB11 ABCB4 ATP8B1
5 cholestasis, progressive familial intrahepatic, 5 33.3 NR1H4 NR1I2 NR1I3
6 atp8b1 deficiency 32.9 ABCB11 ATP8B1 NR1H4
7 cholestasis, progressive familial intrahepatic, 1 32.3 ABCB11 ABCB4 ATP8B1 NR1H4
8 cholestasis 31.6 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 GGT1
9 dubin-johnson syndrome 30.6 ABCC2 ABCC3 SLCO1B1
10 alagille syndrome 1 30.5 ABCB11 ABCB4 ATP8B1
11 cholangitis 30.3 ABCB11 ABCB4 GGT1 GPBAR1
12 progressive familial intrahepatic cholestasis 30.3 ABCB11 ABCB4 ABCC2 ATP8B1 NR1H4 SLCO1B1
13 sclerosing cholangitis 30.2 ABCB11 ABCB4 GGT1 GPBAR1 NR1H4 NR1I2
14 extrahepatic cholestasis 30.1 ABCB4 ABCC2 ABCC3 GGT1
15 liver disease 30.0 ABCB11 ABCB4 ATP8B1 GGT1 NR1H4 SLC25A13
16 citrullinemia, type ii, neonatal-onset 12.4
17 cholestasis, intrahepatic, of pregnancy, 1 12.4
18 myo5b-related progressive familial intrahepatic cholestasis 12.2
19 cholestasis, intrahepatic, of pregnancy 3 12.1
20 bile acid synthesis defect, congenital, 4 12.0
21 bile acid synthesis defect, congenital, 1 12.0
22 citrullinemia, type ii, adult-onset 11.6
23 bile acid synthesis defect, congenital, 2 11.4
24 gilbert syndrome 11.2
25 arthrogryposis, renal dysfunction, and cholestasis 1 11.2
26 north american indian childhood cirrhosis 11.2
27 crigler-najjar syndrome, type ii 11.2
28 bile acid synthesis defect, congenital, 3 11.2
29 multiple sclerosis 10.6
30 hepatitis 10.4
31 amyloidosis 10.4
32 hydrocephalus 10.4
33 hepatitis c 10.3
34 sickle cell disease 10.3
35 hydrocephalus, normal-pressure 10.2
36 hyperbilirubinemia, rotor type 10.2 ABCC2 SLCO1B1 SLCO1B3
37 biliary atresia 10.2
38 viral infectious disease 10.2
39 hypoxia 10.2
40 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.2
41 intracranial hypertension 10.2
42 head injury 10.2
43 autosomal dominant non-syndromic intellectual disability 2 10.2 NR1I2 NR1I3
44 autosomal dominant non-syndromic intellectual disability 3 10.2 NR1I2 NR1I3
45 cholelithiasis 10.1
46 al amyloidosis 10.1
47 cholangitis, primary sclerosing 10.1 ABCB4 GGT1 GPBAR1 NR1I2
48 retinitis pigmentosa 10.1
49 bilirubin metabolic disorder 10.1 ABCC2 GGT1 NR1I3 SLCO1B1
50 cholestasis, benign recurrent intrahepatic, 1 10.1

Graphical network of the top 20 diseases related to Intrahepatic Cholestasis of Pregnancy:



Diseases related to Intrahepatic Cholestasis of Pregnancy

Symptoms & Phenotypes for Intrahepatic Cholestasis of Pregnancy

UMLS symptoms related to Intrahepatic Cholestasis of Pregnancy:


icterus, hepatocellular jaundice

GenomeRNAi Phenotypes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

26 (show all 29)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.41 NR1I2 NR1I3
2 Decreased viability GR00221-A-2 10.41 NR1H4 NR1I2 NR1I3
3 Decreased viability GR00221-A-4 10.41 NR1H4
4 Decreased viability GR00240-S-1 10.41 ADAMTS12 LIPF
5 Decreased viability GR00301-A 10.41 NR1I2 NR1I3
6 Decreased viability GR00381-A-1 10.41 ABCC2 GGT1 SLCO1A2
7 Decreased viability GR00381-A-2 10.41 ABCC2
8 Decreased viability GR00381-A-3 10.41 ABCC2 SLCO1A2
9 Decreased viability GR00402-S-2 10.41 ABCB11 ABCB4 ABCC2 ABCC3 ADAMTS12 ATP8B1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.02 ABCC3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.02 ABCC3 ERP29 GGT1 GPBAR1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.02 ERP29
13 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.02 GPBAR1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-136 10.02 GPBAR1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.02 ABCC3 GGT1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.02 ABCC3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.02 ERP29
18 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.02 GGT1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.02 ABCC3
20 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.02 ABCC3
21 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.02 ERP29
22 Increased shRNA abundance (Z-score > 2) GR00366-A-197 10.02 ERP29
23 Increased shRNA abundance (Z-score > 2) GR00366-A-208 10.02 ABCC3
24 Increased shRNA abundance (Z-score > 2) GR00366-A-24 10.02 GPBAR1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-37 10.02 ERP29
26 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.02 GPBAR1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.02 GPBAR1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.02 GGT1
29 no effect GR00402-S-1 9.62 ABCB11 ABCB4 ABCC2 ABCC3 ADAMTS12 ATP8B1

MGI Mouse Phenotypes related to Intrahepatic Cholestasis of Pregnancy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.83 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 ENPP2
2 liver/biliary system MP:0005370 9.36 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 GPBAR1

Drugs & Therapeutics for Intrahepatic Cholestasis of Pregnancy

Drugs for Intrahepatic Cholestasis of Pregnancy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 3,Phase 2 128-13-2 31401
2
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
3
Metformin Approved Phase 2, Phase 3 657-24-9 14219 4091
4 Gastrointestinal Agents Phase 3,Phase 2
5 Cholagogues and Choleretics Phase 3,Phase 2
6 Liver Extracts Phase 2, Phase 3
7 Hypoglycemic Agents Phase 2, Phase 3
8
Sofosbuvir Approved 1190307-88-0 45375808
9 Estrogens
10 Hormones
11 Bile Acids and Salts
12 Anti-Infective Agents
13 Antiviral Agents

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of Pregnancy Completed NCT01576458 Phase 3 ursodeoxycholic acid;Placebo
2 Metformin in Intrahepatic Cholestasis of Pregnancy Not yet recruiting NCT03056274 Phase 2, Phase 3 Metformin;Ursodeoxycholic Acid
3 Ursodeoxycholic Acid And Cholestasis Of Pregnancy Withdrawn NCT01226823 Phase 3 Ursodeoxycholic Acid;Placebo
4 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of the GlaxoSmithKline (GSK) Biologicals' Respiratory Syncytial Virus (RSV) Investigational Vaccine (GSK3003891A) in Healthy Pregnant Women and Infants Born to Vaccinated Mothers Withdrawn NCT03191383 Phase 2 Placebo (Formulation buffer S9b)
5 Serum Autotaxin Levels in Cholestasis of Pregnancy Unknown status NCT02480478
6 Il-17 Levels in Intrahepatic Cholestasis of Pregnancy Unknown status NCT01898832
7 Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis. Unknown status NCT02192177
8 P-wave Duration and Dispersion in Intrahepatic Cholestasis of Pregnancy Unknown status NCT01906827
9 White Adipose Tissue in Pregnancy Study Unknown status NCT02495987
10 ABCB4 Gene Mutations in Intrahepatic Cholestasis of Pregnancy and Controls Completed NCT00700232
11 Induction of Labor in Intrahepatic Cholestasis of Pregnancy Completed NCT01381939
12 Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women Completed NCT03154268
13 The Metabolic Profile in Intrahepatic Cholestasis of Pregnancy and Diabetes Mellitus Recruiting NCT01499524
14 Bile Acid Effects in Fetal Arrhythmia Study Recruiting NCT03519399
15 Transmission of Chronic Hepatitis C in Pregnancy Recruiting NCT03570112 SOF/VEL- sofosbuvir 400mg and velpatasvir 100mg
16 The Use of Fish Oil Supplementation in Treatment of Intrahepatic Cholestasis of Pregnancy Withdrawn NCT01965054 Not Applicable

Search NIH Clinical Center for Intrahepatic Cholestasis of Pregnancy

Cochrane evidence based reviews: cholestasis, intrahepatic

Genetic Tests for Intrahepatic Cholestasis of Pregnancy

Genetic tests related to Intrahepatic Cholestasis of Pregnancy:

# Genetic test Affiliating Genes
1 Intrahepatic Cholestasis 29

Anatomical Context for Intrahepatic Cholestasis of Pregnancy

MalaCards organs/tissues related to Intrahepatic Cholestasis of Pregnancy:

41
Liver, Skin, Eye, Placenta, Lung, Brain, Bone

Publications for Intrahepatic Cholestasis of Pregnancy

Articles related to Intrahepatic Cholestasis of Pregnancy:

(show top 50) (show all 450)
# Title Authors Year
1
Predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy with dichorionic diamniotic twin pregnancies. ( 29020816 )
2019
2
Treatment of intrahepatic cholestasis of pregnancy with ursodeoxycholic acid associated with improvement of fetal first-degree atrioventricular block. ( 29484735 )
2018
3
Diagnostic and therapeutic profiles of serum bile acids in women with intrahepatic cholestasis of pregnancy-a pseudo-targeted metabolomics study. ( 29709452 )
2018
4
Intrahepatic cholestasis of pregnancy and associated causes of death: a cohort study with follow-up of 27-46A years. ( 29914448 )
2018
5
Effect of inducible nitric oxide synthase and neuropeptide Y in plasma and placentas from intrahepatic cholestasis of pregnancy. ( 29956420 )
2018
6
Impacts of different methods of conception on the perinatal outcome of intrahepatic cholestasis of pregnancy in twin pregnancies. ( 29507303 )
2018
7
Resveratrol Regulating SIRT1-NF-I_B Signal Pathway in Intrahepatic Cholestasis of Pregnancy. ( 29855113 )
2018
8
Assessment of circulating betatrophin levels in intrahepatic cholestasis of pregnancy. ( 29890866 )
2018
9
Perinatal outcomes in intrahepatic cholestasis of pregnancy with monochorionic diamniotic twin pregnancy. ( 29980184 )
2018
10
Does ursodeoxycholic acid improve perinatal outcomes in women with intrahepatic cholestasis of pregnancy? ( 29419378 )
2018
11
Low serum vitamin D level is associated with intrahepatic cholestasis of pregnancy. ( 29978524 )
2018
12
Intrahepatic cholestasis of pregnancy: Shorter duration of labor? ( 29680685 )
2018
13
Waveform analysis of the fetal ECG in labor in patients with intrahepatic cholestasis of pregnancy. ( 30203501 )
2018
14
PPARγ provides anti-inflammatory and protective effects in intrahepatic cholestasis of pregnancy through NF-κB pathway. ( 30219229 )
2018
15
Linc02527 promoted autophagy in Intrahepatic cholestasis of pregnancy. ( 30250023 )
2018
16
Assessment of fetal left ventricular modified myocardial performance index and its prognostic significance for adverse perinatal outcome in intrahepatic cholestasis of pregnancy. ( 30309274 )
2018
17
Therapeutic plasma exchange as a novel treatment for severe intrahepatic cholestasis of pregnancy: Case series and mechanism of action. ( 30321466 )
2018
18
Is It Necessary to Perform the Pharmacological Interventions for Intrahepatic Cholestasis of Pregnancy? A Bayesian Network Meta-Analysis. ( 30357607 )
2018
19
Intrahepatic cholestasis of pregnancy. ( 30372720 )
2018
20
Intrahepatic cholestasis of pregnancy: Review of six national and regional guidelines. ( 30396107 )
2018
21
Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES). ( 30482254 )
2018
22
May circulating steroids reveal a predisposition to intrahepatic cholestasis of pregnancy in non-pregnant women? ( 30484676 )
2018
23
The Serum microRNA Profile of Intrahepatic Cholestasis of Pregnancy: Identification of Novel Noninvasive Biomarkers. ( 30485846 )
2018
24
Intrahepatic Cholestasis of Pregnancy: A Review of Diagnosis and Management. ( 29480924 )
2018
25
Role of ischemia-modified albumin in the evaluation of oxidative stress in intrahepatic cholestasis of pregnancy. ( 29739259 )
2018
26
Biliary transporter gene mutations in severe intrahepatic cholestasis of pregnancy: Diagnostic and management implications. ( 29992621 )
2018
27
Could first- and second-trimester biochemical markers for Down syndrome have a role in predicting intrahepatic cholestasis of pregnancy? ( 30002703 )
2018
28
Magnesium sulphate can alleviate oxidative stress and reduce inflammatory cytokines in rat placenta of intrahepatic cholestasis of pregnancy model. ( 30039470 )
2018
29
The role of ABC transporters' gene polymorphism in the etiology of intrahepatic cholestasis of pregnancy. ( 30091450 )
2018
30
Novel compound heterozygous ABCC2 variants in patients with Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy. ( 30092126 )
2018
31
Adjuvant Use of Rifampin for Refractory Intrahepatic Cholestasis of Pregnancy. ( 30095766 )
2018
32
Expression and significance of dendritic cells and Th17/Treg in serum and placental tissues of patients with intrahepatic cholestasis of pregnancy. ( 28298162 )
2018
33
An alternative method for measuring oxidative stress in intrahepatic cholestasis of pregnancy: thiol/disulphide homeostasis. ( 28462673 )
2018
34
An expanded role for heterozygous mutations of ABCB4, ABCB11, ATP8B1, ABCC2 and TJP2 in intrahepatic cholestasis of pregnancy. ( 28924228 )
2017
35
Correction to: Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy in a Sri Lankan family: a case report. ( 28982379 )
2017
36
Intrahepatic cholestasis of pregnancy or azithromycin-induced intrahepatic cholestasis: A case report. ( 29384912 )
2017
37
Can we predict severity of intrahepatic cholestasis of pregnancy using inflammatory markers? ( 29085705 )
2017
38
Maternal copeptin levels in intrahepatic cholestasis of pregnancy. ( 28552021 )
2017
39
A retrospective cohort review of intrahepatic cholestasis of pregnancy in a South Australian population. ( 28926728 )
2017
40
Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy in a Sri Lankan family: a case report. ( 28923092 )
2017
41
miR-148a-mediated estrogen-induced cholestasis in intrahepatic cholestasis of pregnancy: Role of PXR/MRP3. ( 28575098 )
2017
42
Urinary metabolomic analysis of intrahepatic cholestasis of pregnancy based on high performance liquid chromatography/mass spectrometry. ( 28669684 )
2017
43
Increased levels of the novel hepatokine fetuin B in patients with intrahepatic cholestasis of pregnancy. ( 29233036 )
2017
44
Effect of intrahepatic cholestasis of pregnancy on neonatal birth weight: a meta-analysis. ( 28825589 )
2017
45
Effect of Histone Deacetylase HDAC3 on Cytokines IL-18, IL-12 and TNF-I+ in Patients with Intrahepatic Cholestasis of Pregnancy. ( 28697498 )
2017
46
Sensitivity and Specificity of Biochemical Tests for Diagnosis of Intrahepatic Cholestasis of Pregnancy. ( 28611260 )
2017
47
Intrahepatic Cholestasis of Pregnancy: Spontaneous<i>vs in vitro</i>Fertilization. ( 29201793 )
2017
48
Correction to: Koroglu et al., Increased levels of the novel hepatokine fetuin B in patients with intrahepatic cholestasis of pregnancy. ( 29254409 )
2017
49
Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy. ( 28680707 )
2017
50
Perinatal outcomes associated with intrahepatic cholestasis of pregnancy(). ( 28581354 )
2017

Variations for Intrahepatic Cholestasis of Pregnancy

ClinVar genetic disease variations for Intrahepatic Cholestasis of Pregnancy:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ABCB11 NM_003742.2(ABCB11): c.3148C> T (p.Arg1050Cys) single nucleotide variant Pathogenic rs72549398 GRCh37 Chromosome 2, 169788952: 169788952
2 ABCB11 NM_003742.2(ABCB11): c.3148C> T (p.Arg1050Cys) single nucleotide variant Pathogenic rs72549398 GRCh38 Chromosome 2, 168932442: 168932442
3 ABCB4 NM_018849.2(ABCB4): c.1006-1G> T single nucleotide variant Pathogenic rs772823352 GRCh38 Chromosome 7, 87444976: 87444976
4 ABCB4 NM_018849.2(ABCB4): c.1006-1G> T single nucleotide variant Pathogenic rs772823352 GRCh37 Chromosome 7, 87074292: 87074292

Expression for Intrahepatic Cholestasis of Pregnancy

Search GEO for disease gene expression data for Intrahepatic Cholestasis of Pregnancy.

Pathways for Intrahepatic Cholestasis of Pregnancy

Pathways related to Intrahepatic Cholestasis of Pregnancy according to KEGG:

37
# Name Kegg Source Accession
1 Bile secretion hsa04976

Pathways related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 ABCB11 ABCB4 ABCC3 ENPP2 GGT1 LIPF
2
Show member pathways
13.22 ABCB4 ABCC2 ABCC3 ATP8B1 SLCO1A2 SLCO1B1
3
Show member pathways
12.04 ABCB11 ABCC3 NR1H4 SLCO1A2 SLCO1B1 SLCO1B3
4 11.94 ABCC2 ABCC3 GGT1
5
Show member pathways
11.93 ABCC2 ABCC3 SLCO1B1
6
Show member pathways
11.92 ABCB11 ABCB4 ABCC2 SLCO1A2 SLCO1B1
7
Show member pathways
11.7 ABCB11 ABCC2 SLCO1A2 SLCO1B1 SLCO1B3
8
Show member pathways
11.69 NR1H4 NR1I2 NR1I3
10
Show member pathways
11.49 ABCC2 NR1I2 NR1I3
11 11.41 ABCB11 ABCB4 ABCC2 ABCC3 NR1H4 SLCO1A2
12
Show member pathways
11.28 ABCC2 ABCC3 SLCO1B1 SLCO1B3
13 11.24 ABCB11 ABCB4 ABCC2 ABCC3 NR1H4 NR1I2
14 11.18 ABCC2 ABCC3 NR1I3
15 10.97 ABCC2 ABCC3
16
Show member pathways
10.96 ABCC2 ABCC3 SLCO1A2 SLCO1B1 SLCO1B3
17 10.93 ABCB11 ABCB4 NR1H4
18 10.83 ABCC2 ABCC3
19 10.75 ABCC2 NR1I2 SLCO1B3
20 10.74 ABCC3 NR1I2
21 10.52 ABCC2 ABCC3
22 10.4 ABCB11 ABCC2 ABCC3 NR1H4 NR1I2 NR1I3

GO Terms for Intrahepatic Cholestasis of Pregnancy

Cellular components related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.61 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 SLC25A13
2 RNA polymerase II transcription factor complex GO:0090575 9.33 NR1H4 NR1I2 NR1I3
3 intercellular canaliculus GO:0046581 8.8 ABCB11 ABCB4 ABCC2
4 plasma membrane GO:0005886 10.1 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 ENPP2
5 integral component of membrane GO:0016021 10.07 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 ENPP2

Biological processes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.76 ABCB11 ABCB4 ABCC2 ABCC3 SLC25A13 SLCO1A2
2 steroid hormone mediated signaling pathway GO:0043401 9.61 NR1H4 NR1I2 NR1I3
3 intracellular receptor signaling pathway GO:0030522 9.58 NR1H4 NR1I2 NR1I3
4 drug transmembrane transport GO:0006855 9.54 ABCB4 ABCC2 ATP8B1
5 phospholipid translocation GO:0045332 9.52 ABCB4 ATP8B1
6 bile acid metabolic process GO:0008206 9.51 ATP8B1 NR1H4
7 sodium-independent organic anion transport GO:0043252 9.5 SLCO1A2 SLCO1B1 SLCO1B3
8 ATP hydrolysis coupled anion transmembrane transport GO:0099133 9.49 ABCC2 ABCC3
9 thyroid hormone transport GO:0070327 9.48 ABCC2 SLCO1B1
10 xenobiotic transport GO:0042908 9.46 ABCB4 NR1I2
11 organic anion transport GO:0015711 9.43 SLCO1A2 SLCO1B1 SLCO1B3
12 bile acid and bile salt transport GO:0015721 9.17 ABCB11 ABCC3 ATP8B1 NR1H4 SLCO1A2 SLCO1B1
13 canalicular bile acid transport GO:0015722 9.13 ABCB11 ABCC2 ABCC3

Molecular functions related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.85 ENPP2 NR1H4 NR1I2 NR1I3
2 ATPase activity GO:0016887 9.83 ABCB11 ABCB4 ABCC2 ABCC3
3 transmembrane transporter activity GO:0022857 9.71 ABCC2 ABCC3 SLC25A13
4 transcription regulatory region sequence-specific DNA binding GO:0000976 9.69 NR1H4 NR1I2 NR1I3
5 nuclear receptor transcription coactivator activity GO:0030374 9.65 NR1H4 NR1I2 NR1I3
6 steroid hormone receptor activity GO:0003707 9.63 NR1H4 NR1I2 NR1I3
7 nuclear receptor activity GO:0004879 9.61 NR1H4 NR1I2 NR1I3
8 sodium-independent organic anion transmembrane transporter activity GO:0015347 9.5 SLCO1A2 SLCO1B1 SLCO1B3
9 ATPase-coupled anion transmembrane transporter activity GO:0043225 9.49 ABCC2 ABCC3
10 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.46 ABCB11 ABCB4 ABCC2 ABCC3
11 bile acid transmembrane transporter activity GO:0015125 9.43 SLCO1A2 SLCO1B1 SLCO1B3
12 bile acid receptor activity GO:0038181 9.4 GPBAR1 NR1H4
13 bile acid-exporting ATPase activity GO:0015432 9.37 ABCB11 ABCC3
14 thyroid hormone receptor activity GO:0004887 9.13 NR1H4 NR1I2 NR1I3
15 organic anion transmembrane transporter activity GO:0008514 8.92 ABCC2 ABCC3 SLCO1A2 SLCO1B3

Sources for Intrahepatic Cholestasis of Pregnancy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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