ICP
MCID: INT099
MIFTS: 51

Intrahepatic Cholestasis of Pregnancy (ICP)

Categories: Fetal diseases, Gastrointestinal diseases, Genetic diseases, Liver diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Intrahepatic Cholestasis of Pregnancy

MalaCards integrated aliases for Intrahepatic Cholestasis of Pregnancy:

Name: Intrahepatic Cholestasis of Pregnancy 12 52 25 58 36 43 15 17
Recurrent Intrahepatic Cholestasis of Pregnancy 12 52 25 58
Gravidic Intrahepatic Cholestasis 12 52 58
Pregnancy-Related Cholestasis 52 25 58
Pregnancy Related Cholestasis 12 52
Icp 12 52
Familial Recurrent Intrahepatic Cholestasis of Pregnancy 52
Familial Intrahepatic Cholestasis of Pregnancy 52
Cholestasis, Intrahepatic of Pregnancy 52
Obstetric Cholestasis 25
Ricp 52

Characteristics:

Orphanet epidemiological data:

58
intrahepatic cholestasis of pregnancy
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare hepatic diseases
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:0070227
KEGG 36 H02193
MeSH 43 C535932
MESH via Orphanet 44 C535932
ICD10 via Orphanet 33 O26.6
Orphanet 58 ORPHA69665

Summaries for Intrahepatic Cholestasis of Pregnancy

Genetics Home Reference : 25 Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the liver, impairing liver function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestasis of pregnancy usually becomes apparent in the third trimester of pregnancy. Bile flow returns to normal after delivery of the baby, and the signs and symptoms of the condition disappear. However, they can return during later pregnancies. This condition causes severe itchiness (pruritus) in the expectant mother. The itchiness usually begins on the palms of the hands and the soles of the feet and then spreads to other parts of the body. Occasionally, affected women have yellowing of the skin and whites of the eyes (jaundice). Some studies have shown that women with intrahepatic cholestasis of pregnancy are more likely to develop gallstones sometime in their life than women who do not have the condition. Intrahepatic cholestasis of pregnancy can cause problems for the unborn baby. This condition is associated with an increased risk of premature delivery and stillbirth. Additionally, some infants born to mothers with intrahepatic cholestasis of pregnancy have a slow heart rate and a lack of oxygen during delivery (fetal distress).

MalaCards based summary : Intrahepatic Cholestasis of Pregnancy, also known as recurrent intrahepatic cholestasis of pregnancy, is related to cholestasis, intrahepatic, of pregnancy, 1 and cholestasis, intrahepatic, of pregnancy 3. An important gene associated with Intrahepatic Cholestasis of Pregnancy is ABCB11 (ATP Binding Cassette Subfamily B Member 11), and among its related pathways/superpathways are Bile secretion and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The drugs Metformin and Ursodeoxycholic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and eye, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 An intrahepatic cholestasis characterized by reversible cholestasis typically occurring in the second or third trimester of pregnancy, elevated serum aminotransferases and bile acid level and resolution of symptoms by 2 to 3 weeks after delivery.

NIH Rare Diseases : 52 Intrahepatic cholestasis of pregnancy (ICP) is a disorder of the liver that occurs in women during pregnancy. Cholestasis is a condition that impairs the release of bile (a digestive juice) from liver cells . The bile then builds up in the liver, impairing liver function. Symptoms typically become apparent in the third trimester of pregnancy and can include severe itching (pruritus ). Occasionally, the skin and the whites of the eyes can have a yellow appearance (jaundice ). ICP is additionally associated with risks to the developing baby such as premature delivery and stillbirth . The cause of ICP is largely unknown, although approximately 15% of cases are caused by mutations in either the ABCB11 or ABCB4 genes . Mutations within the ABCB11 and ABCB4 genes are inherited in an autosomal dominant manner. Symptoms of ICP are typically limited to pregnancy. Bile flow returns to normal after delivery and the signs and symptoms of the condition disappear, however, they can return during later pregnancies.

KEGG : 36 Intrahepatic cholestasis of pregnancy (ICP), also called obstetric cholestasis, is the most common pregnancy-specific liver disease. Classic symptoms include generalized pruritus that commonly includes the palms and soles, and biochemical evidence of elevated bile acids, with or without elevated liver function tests (LFTs). The etiology of ICP is influenced by a combination of genetic, endocrine, and environmental factors. Risk factors for ICP include multiple pregnancy, in vitro fertilization, advanced maternal age, history of prior affected pregnancy, positive family history, and hepatitis C infection.

Wikipedia : 74 Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of... more...

Related Diseases for Intrahepatic Cholestasis of Pregnancy

Diseases in the Intrahepatic Cholestasis of Pregnancy family:

Cholestasis, Intrahepatic, of Pregnancy, 1 Cholestasis, Intrahepatic, of Pregnancy 3

Diseases related to Intrahepatic Cholestasis of Pregnancy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 310)
# Related Disease Score Top Affiliating Genes
1 cholestasis, intrahepatic, of pregnancy, 1 34.4 NR1I3 NR1I2 NR1H4 ATP8B1 ABCC2 ABCB4
2 cholestasis, intrahepatic, of pregnancy 3 33.9 ABCB4 ABCB11
3 cholestasis, progressive familial intrahepatic, 1 33.5 NR1H4 ATP8B1 ABCC2 ABCB4 ABCB11
4 cholestasis 31.6 TNF SLCO1B1 SLCO1A2 SLC4A2 NR1I3 NR1I2
5 atp8b1 deficiency 31.5 NR1H4 ATP8B1 ABCB11
6 exanthem 31.2 TNF GPT CYP3A4
7 cholelithiasis 31.2 SLCO1A2 NR1H4 GPT ABCB4
8 familial intrahepatic cholestasis 31.1 SLCO1B3 SLCO1B1 NR1H4 ATP8B1 ABCC2 ABCB4
9 liver disease 31.1 TNF NR1H4 GPT CYP3A4 ATP8B1 ABCC2
10 cholestasis, benign recurrent intrahepatic, 1 31.0 NR1H4 ATP8B1 ABCC3 ABCC2 ABCB4 ABCB11
11 hepatitis a 31.0 TNF GPT CYP3A4
12 progressive familial intrahepatic cholestasis 30.8 SLCO1B3 SLCO1B1 NR1H4 ATP8B1 ABCC3 ABCC2
13 dubin-johnson syndrome 30.8 SLCO1B3 SLCO1B1 SLCO1A2 ATP8B1 ABCC3 ABCC2
14 cholestasis, progressive familial intrahepatic, 3 30.8 NR1H4 ATP8B1 ABCC2 ABCB4 ABCB11
15 cholangitis 30.7 TNF NR1I2 NR1H4 GPT GPBAR1 ENPP2
16 neonatal jaundice 30.6 TNF SLCO1B1 NR1I3
17 diarrhea 30.5 TNF GPT CYP3A4 ABCC2 ABCB1
18 wilson disease 30.4 TNF NR1H4 GPT
19 bilirubin metabolic disorder 30.2 SLCO1B3 SLCO1B1 SLCO1A2 NR1I3 GPT CYP3A4
20 primary biliary cirrhosis 29.7 TNF SLCO1B3 SLCO1B1 SLC4A2 NR1I3 NR1I2
21 hepatocellular carcinoma 29.6 TNF SLCO1B3 SLC4A2 NR1H4 GPT ENPP2
22 hydrocephalus 10.7
23 intracranial hypertension 10.7
24 head injury 10.7
25 parenteral nutrition-associated cholestasis 10.6 GPT ABCB4
26 pre-eclampsia 10.6
27 traumatic brain injury 10.6
28 bile duct cysts 10.6 GPT ATP8B1 ABCB4
29 pericholangitis 10.6 ABCB4 ABCB11
30 alagille syndrome 1 10.6 ATP8B1 ABCB4 ABCB11
31 citrullinemia, classic 10.6 GPT ATP8B1 ABCB11
32 heart defects, congenital, and other congenital anomalies 10.6 NR1H4 GPBAR1 ABCB11
33 choline deficiency disease 10.6 NR1H4 GPT GPBAR1
34 sitosterolemia 10.6 ATP8B1 ABCB4 ABCB11
35 hepatic vascular disease 10.6 TNF NR1H4 GPT
36 suppurative cholangitis 10.6 GPT ABCB4
37 autosomal dominant non-syndromic intellectual disability 3 10.6 ABCB4 ABCB11
38 gallbladder disease 10.6 NR1H4 GPT ABCB4 ABCB11
39 hyperbilirubinemia, rotor type 10.6 SLCO1B3 SLCO1B1 ABCC2
40 cholestasis, progressive familial intrahepatic, 4 10.5 NR1H4 ATP8B1 ABCC2 ABCB4 ABCB11
41 cerebrotendinous xanthomatosis 10.5 NR1I2 NR1H4 CYP3A4
42 methotrexate toxicity 10.5 SLCO1B1 GPT ABCB1
43 nasopharyngitis 10.5 TNF GPT CYP3A4
44 soft tissue sarcoma 10.5 TNF ABCB1
45 granulomatous hepatitis 10.5 TNF GPT
46 obstructive jaundice 10.5 TNF GPT GPBAR1 ABCC2
47 bronchiectasis 3 10.5 SLCO1B3 CYP3A4
48 colchicine resistance 10.5 ABCB11 ABCB1
49 portal hypertension 10.5 TNF NR1H4 GPT
50 functional diarrhea 10.5 NR1H4 GPBAR1

Graphical network of the top 20 diseases related to Intrahepatic Cholestasis of Pregnancy:



Diseases related to Intrahepatic Cholestasis of Pregnancy

Symptoms & Phenotypes for Intrahepatic Cholestasis of Pregnancy

GenomeRNAi Phenotypes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.75 NR1I2 NR1I3
2 Decreased viability GR00221-A-2 9.75 NR1H4 NR1I2 NR1I3
3 Decreased viability GR00221-A-4 9.75 NR1H4
4 Decreased viability GR00249-S 9.75 ABCB1 ABCC3 NR1H4 NR1I3 SLC4A2 SLCO1B3
5 Decreased viability GR00301-A 9.75 NR1I2 NR1I3
6 Decreased viability GR00381-A-1 9.75 ABCC2 SLCO1A2
7 Decreased viability GR00381-A-2 9.75 ABCC2
8 Decreased viability GR00381-A-3 9.75 ABCC2 SLCO1A2
9 Decreased viability GR00386-A-1 9.75 NR1I3 SLCO1A2 SLCO1B1
10 Decreased viability GR00402-S-2 9.75 ABCB1 ABCC3 GPT TNF

MGI Mouse Phenotypes related to Intrahepatic Cholestasis of Pregnancy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.83 ABCB1 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1
2 liver/biliary system MP:0005370 9.4 ABCB1 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1

Drugs & Therapeutics for Intrahepatic Cholestasis of Pregnancy

Drugs for Intrahepatic Cholestasis of Pregnancy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
3
Methionine Approved, Nutraceutical Phase 4 63-68-3 6137
4 Liver Extracts Phase 4
5 Hypoglycemic Agents Phase 4
6 Gastrointestinal Agents Phase 4
7
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
8
Dinoprostone Approved 363-24-6 5280360
9 Estrogens
10 Bile Acids and Salts
11 Hormones

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4
2 Randomised Controlled Trial of Gestational Treatment With Ursodeoxycholic Acid Compared to Metformin to Reduce Effects of Diabetes Mellitus Not yet recruiting NCT04407650 Phase 4 Metformin;Ursodeoxycholic Acid
3 METformin in Intrahepatic Cholestasis of Pregnancy (METRIC) Study Unknown status NCT03056274 Phase 2, Phase 3 Metformin;Ursodeoxycholic Acid
4 Randomised Placebo-controlled Study of Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of Pregnancy Completed NCT01576458 Phase 3 ursodeoxycholic acid;Placebo
5 Intrahepatic Cholestasis Of Pregnancy: Clinical Impact Of Ursodeoxycholic Acid Treatment Withdrawn NCT01226823 Phase 3 Ursodeoxycholic Acid;Placebo
6 Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis. Unknown status NCT02192177
7 Diagnostic Accuracy of Serum Autotaxin Levels in Cholestasis of Pregnancy Unknown status NCT02480478
8 P-wave Duration and Dispersion in Intrahepatic Cholestasis of Pregnancy Unknown status NCT01906827
9 to Investigate the Maternal Serum IL-17 Levels in Pregnant Women With Intrahepatic Cholestasis of Pregnancy Unknown status NCT01898832
10 Mutations and Polymorphisms of Gene ABCB4 Among Women Suffering From Intrahepatic Cholestasis of Pregnancy. A Study With a Control Group. Completed NCT00700232
11 Induction of Labor in Intrahepatic Cholestasis of Pregnancy Completed NCT01381939
12 Feasibility and Acceptability of the Combination of Propess and AN24 Monica for Outpatient Labour Induction (PRAM) Completed NCT01026948 Dinoprostone
13 Investigation of the Effect of Elevated Serum Bile Acids in Intrahepatic Cholestasis of Pregnancy (ICP) on the Fetal Cardiac Rhythm and on Myometrial Contractility: a Prospective Case-control Pilot Study Recruiting NCT03519399
14 Adaptations in Subcutaneous and Visceral Adipose Tissue Metabolism During Normal and Pathological Pregnancies Recruiting NCT02495987
15 Genetic Polymorphisms of ABCB11 and ABCB4 in Women With Intrahepatic Cholestasis of Pregnancy (ICP) and in Their First Degree Relatives Recruiting NCT04281082 ursofalk
16 A Longitudinal Study of Alterations in Metabolic Markers and Gut Hormones in Pregnant and Non-pregnant Patients With Intrahepatic Cholestasis of Pregnancy, Gestational Diabetes Mellitus and Normal Pregnant and Non-pregnant Controls Recruiting NCT01499524
17 Secondary Sclerosing Cholangitis in Critically Ill Patients (SSC-CIP): A Pilot Study on the Possible Genetic Basis of the Disease Recruiting NCT02545309
18 The Use of Fish Oil Supplementation in Treatment of Intrahepatic Cholestasis of Pregnancy Withdrawn NCT01965054

Search NIH Clinical Center for Intrahepatic Cholestasis of Pregnancy

Cochrane evidence based reviews: intrahepatic cholestasis of pregnancy

Genetic Tests for Intrahepatic Cholestasis of Pregnancy

Anatomical Context for Intrahepatic Cholestasis of Pregnancy

MalaCards organs/tissues related to Intrahepatic Cholestasis of Pregnancy:

40
Liver, Skin, Eye, Testes, Heart, Placenta, Lung

Publications for Intrahepatic Cholestasis of Pregnancy

Articles related to Intrahepatic Cholestasis of Pregnancy:

(show top 50) (show all 964)
# Title Authors PMID Year
1
ABCB4 gene mutations and single-nucleotide polymorphisms in women with intrahepatic cholestasis of pregnancy. 61 6
19584064 2009
2
ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy. 61 6
15888793 2005
3
Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. 6 61
10767346 2000
4
Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy. 6 61
9923886 1999
5
ABCB4 heterozygous gene mutations associated with fibrosing cholestatic liver disease in adults. 6
18482588 2008
6
Characterization of mutations in ATP8B1 associated with hereditary cholestasis. 6
15239083 2004
7
MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. 6
11313316 2001
8
Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis. 6
8666348 1996
9
Fetal coenzyme Q10 deficiency in intrahepatic cholestasis of pregnancy. 61
31477533 2020
10
Coenzyme Q 10 supplementation: A potential therapeutic option for the treatment of intrahepatic cholestasis of pregnancy. 61
32534074 2020
11
Chronic cholestatic liver disease and pregnancy - not to be confused with intrahepatic cholestasis of pregnancy. 61
32077233 2020
12
Assessment of fetal left ventricular modified myocardial performance index and its prognostic significance for adverse perinatal outcome in intrahepatic cholestasis of pregnancy. 61
30309274 2020
13
Increased syndecan-1 and glypican-3 predict poor perinatal outcome and treatment resistance in intrahepatic cholestasis. 61
31919038 2020
14
Signalling by lysophosphatidate and its health implications. 61
32451553 2020
15
Circulating Nucleic Acids in Maternal Plasma and Serum in Pregnancy Complications: Are They Really Useful in Clinical Practice? A Systematic Review. 61
32367458 2020
16
Intrahepatic Cholestasis in Pregnancy: Review of the Literature. 61
32384779 2020
17
[A Case of Acute Aortic Dissection Following Intrapartum in a Patient with Marfan ' s Syndrome]. 61
32543157 2020
18
Post-partum Primary Biliary Cholangitis Preceded by Intrahepatic Cholestasis of Pregnancy in Three First Nation Patients. 61
32440749 2020
19
Intrahepatic cholestasis of pregnancy: are in vitro fertilization pregnancies at risk? 61
32419565 2020
20
A novel etiologic factor of highly elevated cholestanol levels: progressive familial intrahepatic cholestasis. 61
32229667 2020
21
Variants in ABCB4 (MDR3) across the spectrum of cholestatic liver diseases in adults. 61
32376413 2020
22
Urinary concentrations of phthalate metabolites during gestation and intrahepatic cholestasis of pregnancy: a population-based birth cohort study. 61
31975012 2020
23
Thiopurine hepatotoxicity can mimic intrahepatic cholestasis of pregnancy. 61
31109900 2020
24
The Alterations in Alcohol Dehydrogenase Activity in the Sera of Women With Intrahepatic Cholestasis of Pregnancy. 61
32234889 2020
25
Liver Diseases in the Perinatal Period: Interactions Between Mother and Infant. 61
31925801 2020
26
Role of sphingolipids in the pathogenesis of intrahepatic cholestasis. 61
31733339 2020
27
Elevated international normalized ratio (INR) and new diagnosis of hepatitis C associated with severe intrahepatic cholestasis of pregnancy (ICP): A case report. 61
32055455 2020
28
Association between intrahepatic cholestasis of pregnancy and risk of gestational diabetes and preeclampsia: a systematic review and meta-analysis. 61
32326772 2020
29
The Impact of Assisted Reproductive Technology in Twin Pregnancies Complicated by Intrahepatic Cholestasis of Pregnancy: a Retrospective Cohort Study. 61
32198731 2020
30
Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy. 61
32127609 2020
31
Effect of ursodeoxycholic acid therapy due to pregnant intrahepatic cholestasis on chemerin and irisin levels. 61
32061000 2020
32
Intrahepatic cholestasis of pregnancy as a risk factor for preeclampsia. 61
32034507 2020
33
Reply to: "UDCA therapy in intrahepatic cholestasis of pregnancy?" 61
31892410 2020
34
Intrahepatic Cholestasis of Pregnancy. 61
31764000 2020
35
UDCA therapy in intrahepatic cholestasis of pregnancy? 61
31864669 2020
36
ABCB4 disease: Many faces of one gene deficiency. 61
31759867 2020
37
New tight junction protein 2 variant causing progressive familial intrahepatic cholestasis type 4 in adults: A case report. 61
32089630 2020
38
Predicting poor outcomes and the need for surgical treatment in neonates with meconium peritonitis. 61
31713898 2020
39
Liver Disease in Pregnancy: What's New. 61
32025601 2020
40
The interpretation of liver function tests in pregnancy. 61
32359686 2020
41
Perinatal outcomes of intrahepatic cholestasis during pregnancy: An 8-year case-control study. 61
32074108 2020
42
Pregnancy Outcome of Women with Chronic Hepatitis B who Discontinued Antiviral Treatment before or in the Early Pregnancy. 61
32038100 2020
43
Does mild intrahepatic cholestasis of pregnancy require an aggressive management? Evidence from a prospective observational study focused on adverse perinatal outcomes and pathological placental findings. 61
31957515 2020
44
Evaluation of predictive value of biochemical markers for adverse obstetrics outcomes in pregnancies complicated by cholestasis. 61
32495933 2020
45
A systematic scoping review of clinical indications for induction of labour. 61
31995603 2020
46
Genetic contribution of ABCC2 to Dubin-Johnson syndrome and inherited cholestatic disorders. 61
31544333 2020
47
Assessment of circulating betatrophin levels in intrahepatic cholestasis of pregnancy. 61
29890866 2019
48
Intrahepatic cholestasis of pregnancy and comorbidity: A 44-year follow-up study. 61
31355915 2019
49
Associations between Maternal Lipid Profiles and Pregnancy Complications: A Prospective Population-Based Study. 61
31891957 2019
50
Enzymatic quantification of total serum bile acids as a monitoring strategy for women with intrahepatic cholestasis of pregnancy receiving ursodeoxycholic acid treatment: a cohort study. 61
31483939 2019

Variations for Intrahepatic Cholestasis of Pregnancy

ClinVar genetic disease variations for Intrahepatic Cholestasis of Pregnancy:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 ABCB11 NM_003742.4(ABCB11):c.3148C>T (p.Arg1050Cys)SNV Pathogenic 374098 rs72549398 2:169788952-169788952 2:168932442-168932442

Expression for Intrahepatic Cholestasis of Pregnancy

Search GEO for disease gene expression data for Intrahepatic Cholestasis of Pregnancy.

Pathways for Intrahepatic Cholestasis of Pregnancy

Pathways related to Intrahepatic Cholestasis of Pregnancy according to KEGG:

36
# Name Kegg Source Accession
1 Bile secretion hsa04976

Pathways related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.37 SLCO1B3 SLCO1B1 SLCO1A2 SLC4A2 ATP8B1 ABCC3
2 12.43 CYP3A4 ABCC3 ABCC2 ABCB1
3
Show member pathways
12.28 SLCO1B3 SLCO1B1 SLCO1A2 NR1H4 ABCC3 ABCB11
4
Show member pathways
12.07 SLCO1B1 SLCO1A2 ABCC2 ABCB4 ABCB11 ABCB1
5
Show member pathways
12.06 SLCO1B1 ABCC3 ABCC2 ABCB1
6
Show member pathways
11.98 SLCO1B3 SLCO1B1 SLCO1A2 CYP3A4 ABCC3 ABCC2
7
Show member pathways
11.79 SLCO1B3 SLCO1B1 SLCO1A2 CYP3A4 ABCC3 ABCC2
8
Show member pathways
11.75 NR1I3 NR1I2 NR1H4
9
Show member pathways
11.74 NR1I3 NR1I2 CYP3A4 ABCC2 ABCB1
10
Show member pathways
11.69 CYP3A4 ABCC3 ABCC2
12
Show member pathways
11.65 SLCO1B1 CYP3A4 ABCC2 ABCB1
13
Show member pathways
11.62 SLCO1B3 NR1I2 CYP3A4 ABCC2 ABCB1
14 11.45 SLCO1B3 SLCO1B1 CYP3A4 ABCB1
15
Show member pathways
11.41 SLCO1B3 SLCO1B1 NR1I3 NR1I2 CYP3A4 ABCB1
16 11.36 NR1I3 CYP3A4 ABCC3 ABCC2 ABCB1
17 11.35 NR1I3 NR1I2 NR1H4 CYP3A4 ABCC3 ABCC2
18 11.32 SLCO1B3 SLCO1B1 SLCO1A2 SLC4A2 NR1H4 CYP3A4
19 11.27 TNF ABCC3 ABCC2
20 11.13 NR1H4 CYP3A4 ABCB4 ABCB11
21
Show member pathways
11.03 SLCO1B3 SLCO1B1 SLCO1A2 ABCC3 ABCC2 ABCB1
22 11.02 ABCC3 ABCC2 ABCB1
23 11.01 NR1I3 NR1I2 ABCC3 ABCC2 ABCB1
24 11 NR1I2 CYP3A4 ABCC3 ABCB1
25 10.84 SLCO1B1 NR1I3 NR1I2 NR1H4 CYP3A4 ABCC3
26 10.81 CYP3A4 ABCB1
27
Show member pathways
10.81 SLCO1A2 ABCB1
28 10.78 CYP3A4 ABCC3 ABCC2 ABCB1
29 10.77 TNF NR1H4

GO Terms for Intrahepatic Cholestasis of Pregnancy

Cellular components related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.13 TNF SLCO1B3 SLCO1B1 SLCO1A2 SLC4A2 GPBAR1
2 integral component of membrane GO:0016021 10 TNF SLCO1B3 SLCO1B1 SLCO1A2 SLC4A2 GPBAR1
3 apical plasma membrane GO:0016324 9.65 SLC4A2 ATP8B1 ABCC2 ABCB4 ABCB1
4 integral component of plasma membrane GO:0005887 9.61 TNF SLCO1B3 SLCO1B1 SLCO1A2 ATP8B1 ABCC3
5 RNA polymerase II transcription factor complex GO:0090575 9.54 NR1I3 NR1I2 NR1H4
6 intercellular canaliculus GO:0046581 8.8 ABCC2 ABCB4 ABCB11

Biological processes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 10.01 NR1I3 NR1I2 NR1H4 ENPP2 CYP3A4 ABCB4
2 negative regulation of gene expression GO:0010629 9.89 UCN TNF ERP29 ABCC2
3 transmembrane transport GO:0055085 9.81 SLCO1B3 SLCO1B1 SLCO1A2 SLC4A2 ABCC3 ABCC2
4 cellular response to lipopolysaccharide GO:0071222 9.8 TNF NR1I3 NR1I2 NR1H4 ABCC2
5 cholesterol homeostasis GO:0042632 9.76 NR1I3 NR1I2 NR1H4
6 steroid hormone mediated signaling pathway GO:0043401 9.72 NR1I3 NR1I2 NR1H4
7 intracellular receptor signaling pathway GO:0030522 9.7 NR1I3 NR1I2 NR1H4
8 lipid homeostasis GO:0055088 9.67 NR1I3 NR1I2 NR1H4 ABCB4
9 response to lipid GO:0033993 9.65 NR1I3 NR1I2 NR1H4
10 phospholipid translocation GO:0045332 9.63 ATP8B1 ABCB4 ABCB1
11 sodium-independent organic anion transport GO:0043252 9.61 SLCO1B3 SLCO1B1 SLCO1A2
12 bile acid metabolic process GO:0008206 9.58 NR1H4 ATP8B1
13 xenobiotic transport GO:0042908 9.57 NR1I2 ABCC3
14 transepithelial transport GO:0070633 9.56 ABCC2 ABCB1
15 drug transport across blood-brain barrier GO:1990962 9.51 ABCC2 ABCB1
16 cellular response to bile acid GO:1903413 9.5 NR1H4 GPBAR1 ABCB4
17 ceramide translocation GO:0099040 9.49 ABCB4 ABCB1
18 canalicular bile acid transport GO:0015722 9.43 ABCC3 ABCC2 ABCB11
19 organic anion transport GO:0015711 9.35 SLCO1B3 SLCO1B1 SLCO1A2 ABCC3 ABCC2
20 bile acid and bile salt transport GO:0015721 9.23 SLCO1B3 SLCO1B1 SLCO1A2 NR1H4 ATP8B1 ABCC3

Molecular functions related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region sequence-specific DNA binding GO:0000976 9.86 TNF NR1I3 NR1I2 NR1H4
2 ATPase activity GO:0016887 9.8 ABCC3 ABCC2 ABCB4 ABCB11 ABCB1
3 nuclear receptor transcription coactivator activity GO:0030374 9.72 NR1I3 NR1I2 NR1H4
4 steroid hormone receptor activity GO:0003707 9.71 NR1I3 NR1I2 NR1H4
5 nuclear receptor activity GO:0004879 9.69 NR1I3 NR1I2 NR1H4
6 transcription factor activity, direct ligand regulated sequence-specific DNA binding GO:0098531 9.54 NR1I3 NR1I2 NR1H4
7 phosphatidylcholine-translocating ATPase activity GO:0090554 9.52 ABCB4 ABCB1
8 sodium-independent organic anion transmembrane transporter activity GO:0015347 9.5 SLCO1B3 SLCO1B1 SLCO1A2
9 xenobiotic transmembrane transporting ATPase activity GO:0008559 9.49 ABCC2 ABCB1
10 ceramide-translocating ATPase activity GO:0099038 9.48 ABCB4 ABCB1
11 bile acid receptor activity GO:0038181 9.46 NR1H4 GPBAR1
12 bile acid-exporting ATPase activity GO:0015432 9.43 ABCC3 ABCB11
13 xenobiotic transmembrane transporter activity GO:0042910 9.43 ABCC3 ABCC2 ABCB1
14 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.35 ABCC3 ABCC2 ABCB4 ABCB11 ABCB1
15 bile acid transmembrane transporter activity GO:0015125 9.33 SLCO1B3 SLCO1B1 SLCO1A2
16 organic anion transmembrane transporter activity GO:0008514 8.92 SLCO1B3 SLCO1A2 ABCC3 ABCC2

Sources for Intrahepatic Cholestasis of Pregnancy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
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72 UMLS via Orphanet
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