ICP
MCID: INT099
MIFTS: 50

Intrahepatic Cholestasis of Pregnancy (ICP)

Categories: Fetal diseases, Gastrointestinal diseases, Genetic diseases, Liver diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Intrahepatic Cholestasis of Pregnancy

MalaCards integrated aliases for Intrahepatic Cholestasis of Pregnancy:

Name: Intrahepatic Cholestasis of Pregnancy 12 53 25 59 37 44 15 17
Recurrent Intrahepatic Cholestasis of Pregnancy 12 53 25 59
Gravidic Intrahepatic Cholestasis 12 53 59
Pregnancy-Related Cholestasis 53 25 59
Pregnancy Related Cholestasis 12 53
Icp 12 53
Familial Recurrent Intrahepatic Cholestasis of Pregnancy 53
Familial Intrahepatic Cholestasis of Pregnancy 53
Cholestasis, Intrahepatic of Pregnancy 53
Obstetric Cholestasis 25
Ricp 53

Characteristics:

Orphanet epidemiological data:

59
intrahepatic cholestasis of pregnancy
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:0070227
KEGG 37 H02193
MeSH 44 C535932
MESH via Orphanet 45 C535932
ICD10 via Orphanet 34 O26.6
Orphanet 59 ORPHA69665

Summaries for Intrahepatic Cholestasis of Pregnancy

Genetics Home Reference : 25 Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the liver, impairing liver function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestasis of pregnancy usually becomes apparent in the third trimester of pregnancy. Bile flow returns to normal after delivery of the baby, and the signs and symptoms of the condition disappear. However, they can return during later pregnancies. This condition causes severe itchiness (pruritus) in the expectant mother. The itchiness usually begins on the palms of the hands and the soles of the feet and then spreads to other parts of the body. Occasionally, affected women have yellowing of the skin and whites of the eyes (jaundice). Some studies have shown that women with intrahepatic cholestasis of pregnancy are more likely to develop gallstones sometime in their life than women who do not have the condition. Intrahepatic cholestasis of pregnancy can cause problems for the unborn baby. This condition is associated with an increased risk of premature delivery and stillbirth. Additionally, some infants born to mothers with intrahepatic cholestasis of pregnancy have a slow heart rate and a lack of oxygen during delivery (fetal distress).

MalaCards based summary : Intrahepatic Cholestasis of Pregnancy, also known as recurrent intrahepatic cholestasis of pregnancy, is related to cholestasis, progressive familial intrahepatic, 1 and atp8b1 deficiency. An important gene associated with Intrahepatic Cholestasis of Pregnancy is NR1H4 (Nuclear Receptor Subfamily 1 Group H Member 4), and among its related pathways/superpathways are Bile secretion and Synthesis of bile acids and bile salts. The drugs Methionine and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and eye, and related phenotypes are no effect and homeostasis/metabolism

Disease Ontology : 12 An intrahepatic cholestasis characterized by reversible cholestasis typically occurring in the second or third trimester of pregnancy, elevated serum aminotransferases and bile acid level and resolution of symptoms by 2 to 3 weeks after delivery.

NIH Rare Diseases : 53 Intrahepatic cholestasis of pregnancy (ICP) is a disorder of the liver that occurs in women during pregnancy. Cholestasis is a condition that impairs the release of bile (a digestive juice) from liver cells. The bile then builds up in the liver, impairing liver function. Symptoms typically become apparent in the third trimester of pregnancy and can include severe itching (pruritus). Occasionally, the skin and the whites of the eyes can have a yellow appearance (jaundice). ICP is additionally associated with risks to the developing baby such as premature delivery and stillbirth. The cause of ICP is largely unknown, although approximately 15% of cases are caused by mutations in either the ABCB11 or ABCB4 genes. Mutations within the ABCB11 and ABCB4 genes are inherited in an autosomal dominant manner. Symptoms of ICP are typically limited to pregnancy. Bile flow returns to normal after delivery and the signs and symptoms of the condition disappear, however, they can return during later pregnancies.

KEGG : 37
Intrahepatic cholestasis of pregnancy (ICP), also called obstetric cholestasis, is the most common pregnancy-specific liver disease. Classic symptoms include generalized pruritus that commonly includes the palms and soles, and biochemical evidence of elevated bile acids, with or without elevated liver function tests (LFTs). The etiology of ICP is influenced by a combination of genetic, endocrine, and environmental factors. Risk factors for ICP include multiple pregnancy, in vitro fertilization, advanced maternal age, history of prior affected pregnancy, positive family history, and hepatitis C infection.

Wikipedia : 75 Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of... more...

Related Diseases for Intrahepatic Cholestasis of Pregnancy

Diseases in the Intrahepatic Cholestasis of Pregnancy family:

Cholestasis, Intrahepatic, of Pregnancy, 1 Cholestasis, Intrahepatic, of Pregnancy 3

Diseases related to Intrahepatic Cholestasis of Pregnancy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 267)
# Related Disease Score Top Affiliating Genes
1 cholestasis, progressive familial intrahepatic, 1 33.3 NR1H4 ATP8B1 ABCB4 ABCB11
2 atp8b1 deficiency 31.4 NR1H4 ATP8B1 ABCB11
3 cholestasis 31.4 NR1I3 NR1I2 NR1H4 GPT ATP8B1 ABCC3
4 cholelithiasis 31.0 NR1H4 GPT ABCB4
5 liver disease 30.9 NR1H4 GPT ATP8B1 ABCB4 ABCB11
6 cholestasis, progressive familial intrahepatic, 3 30.8 ATP8B1 ABCB4 ABCB11
7 bilirubin metabolic disorder 30.8 NR1I3 GPT ABCC2
8 progressive familial intrahepatic cholestasis 30.7 SLCO1B3 NR1H4 ATP8B1 ABCC2 ABCB4 ABCB11
9 cholangitis 30.6 GPT GPBAR1 ABCB4 ABCB11
10 bile duct disease 29.1 SLCO1A2 NR1I2 NR1H4 GPT GPBAR1 ATP8B1
11 cholestasis, intrahepatic, of pregnancy, 1 12.5
12 cholestasis, intrahepatic, of pregnancy 3 12.5
13 hydrocephalus 10.7
14 congenital hydrocephalus 10.7
15 intracranial hypertension 10.7
16 head injury 10.7
17 traumatic brain injury 10.6
18 pre-eclampsia 10.6
19 cholestasis, progressive familial intrahepatic, 4 10.6 ATP8B1 ABCB4 ABCB11
20 ocular motor apraxia 10.5
21 gestational diabetes 10.5
22 alagille syndrome 1 10.5 ATP8B1 ABCB4 ABCB11
23 familial intrahepatic cholestasis 10.5
24 cholestasis, progressive familial intrahepatic, 2 10.5 NR1H4 ATP8B1 ABCB4 ABCB11
25 cholestasis, progressive familial intrahepatic, 5 10.4 NR1I3 NR1I2 NR1H4
26 hydrocephalus, normal-pressure 10.4
27 eclampsia 10.4
28 autosomal dominant non-syndromic intellectual disability 3 10.4 NR1I3 NR1I2
29 herpes simplex 10.4
30 biliary atresia 10.4 NR1H4 GPT ATP8B1
31 triiodothyronine receptor auxiliary protein 10.4
32 gallbladder disease 1 10.4
33 viral hepatitis 10.4
34 autosomal dominant non-syndromic intellectual disability 2 10.3 NR1I3 NR1I2
35 rare surgical neurologic disease 10.3
36 extrahepatic cholestasis 10.3 GPT ABCC3 ABCC2 ABCB4
37 cholangitis, primary sclerosing 10.3 NR1I2 GPT GPBAR1 ABCB4
38 rapidly involuting congenital hemangioma 10.3
39 exanthem 10.3
40 hypothyroidism 10.3
41 hepatitis c 10.3
42 lipid metabolism disorder 10.3
43 chronic pain 10.3
44 sclerosing cholangitis 10.2 NR1I2 NR1H4 GPBAR1 ABCB4 ABCB11
45 hyperbilirubinemia, rotor type 10.2 SLCO1B3 ABCC2
46 cardiac arrhythmia 10.2
47 dubin-johnson syndrome 10.2
48 cholestasis, benign recurrent intrahepatic, 1 10.2
49 hellp syndrome 10.2
50 placenta disease 10.2

Graphical network of the top 20 diseases related to Intrahepatic Cholestasis of Pregnancy:



Diseases related to Intrahepatic Cholestasis of Pregnancy

Symptoms & Phenotypes for Intrahepatic Cholestasis of Pregnancy

GenomeRNAi Phenotypes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 ABCB11 ABCB4 ABCC2 ABCC3 ADAMTS12 ATP8B1

MGI Mouse Phenotypes related to Intrahepatic Cholestasis of Pregnancy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.83 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 CRHR2
2 liver/biliary system MP:0005370 9.36 ABCB11 ABCB4 ABCC2 ABCC3 ATP8B1 ESR2

Drugs & Therapeutics for Intrahepatic Cholestasis of Pregnancy

Drugs for Intrahepatic Cholestasis of Pregnancy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methionine Approved, Nutraceutical Phase 4 63-68-3 6137
2 Liver Extracts Phase 4
3
Metformin Approved Phase 2, Phase 3 657-24-9 4091 14219
4
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
5 Hypoglycemic Agents Phase 2, Phase 3
6
Dinoprostone Approved 363-24-6 5280360
7 Estrogens
8 Oxytocics
9 Bile Acids and Salts
10 Hormones

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4
2 Randomised Placebo-controlled Study of Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of Pregnancy Completed NCT01576458 Phase 3 ursodeoxycholic acid;Placebo
3 METformin in Intrahepatic Cholestasis of Pregnancy (METRIC) Study Not yet recruiting NCT03056274 Phase 2, Phase 3 Metformin;Ursodeoxycholic Acid
4 Intrahepatic Cholestasis Of Pregnancy: Clinical Impact Of Ursodeoxycholic Acid Treatment Withdrawn NCT01226823 Phase 3 Ursodeoxycholic Acid;Placebo
5 Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis. Unknown status NCT02192177
6 Diagnostic Accuracy of Serum Autotaxin Levels in Cholestasis of Pregnancy Unknown status NCT02480478
7 P-wave Duration and Dispersion in Intrahepatic Cholestasis of Pregnancy Unknown status NCT01906827
8 to Investigate the Maternal Serum IL-17 Levels in Pregnant Women With Intrahepatic Cholestasis of Pregnancy Unknown status NCT01898832
9 Mutations and Polymorphisms of Gene ABCB4 Among Women Suffering From Intrahepatic Cholestasis of Pregnancy. A Study With a Control Group. Completed NCT00700232
10 Induction of Labor in Intrahepatic Cholestasis of Pregnancy Completed NCT01381939
11 Feasibility and Acceptability of the Combination of Propess and AN24 Monica for Outpatient Labour Induction (PRAM) Completed NCT01026948 Dinoprostone
12 Investigation of the Effect of Elevated Serum Bile Acids in Intrahepatic Cholestasis of Pregnancy (ICP) on the Fetal Cardiac Rhythm and on Myometrial Contractility: a Prospective Case-control Pilot Study Recruiting NCT03519399
13 Adaptations in Subcutaneous and Visceral Adipose Tissue Metabolism During Normal and Pathological Pregnancies Recruiting NCT02495987
14 A Longitudinal Study of Alterations in Metabolic Markers and Gut Hormones in Pregnant and Non-pregnant Patients With Intrahepatic Cholestasis of Pregnancy, Gestational Diabetes Mellitus and Normal Pregnant and Non-pregnant Controls Recruiting NCT01499524
15 Secondary Sclerosing Cholangitis in Critically Ill Patients (SSC-CIP): A Pilot Study on the Possible Genetic Basis of the Disease Recruiting NCT02545309
16 The Use of Fish Oil Supplementation in Treatment of Intrahepatic Cholestasis of Pregnancy Withdrawn NCT01965054

Search NIH Clinical Center for Intrahepatic Cholestasis of Pregnancy

Cochrane evidence based reviews: intrahepatic cholestasis of pregnancy

Genetic Tests for Intrahepatic Cholestasis of Pregnancy

Anatomical Context for Intrahepatic Cholestasis of Pregnancy

MalaCards organs/tissues related to Intrahepatic Cholestasis of Pregnancy:

41
Liver, Skin, Eye, Testes, Heart, Placenta, Lung

Publications for Intrahepatic Cholestasis of Pregnancy

Articles related to Intrahepatic Cholestasis of Pregnancy:

(show top 50) (show all 907)
# Title Authors PMID Year
1
ABCB4 gene mutations and single-nucleotide polymorphisms in women with intrahepatic cholestasis of pregnancy. 38 71
19584064 2009
2
ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy. 38 71
15888793 2005
3
Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. 38 71
10767346 2000
4
Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy. 38 71
9923886 1999
5
ABCB4 heterozygous gene mutations associated with fibrosing cholestatic liver disease in adults. 71
18482588 2008
6
Characterization of mutations in ATP8B1 associated with hereditary cholestasis. 71
15239083 2004
7
MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. 71
11313316 2001
8
Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis. 71
8666348 1996
9
Role of ischemia-modified albumin in the evaluation of oxidative stress in intrahepatic cholestasis of pregnancy. 38
29739259 2019
10
Correction to: Koroglu et al., Increased levels of the novel hepatokine fetuin B in patients with intrahepatic cholestasis of pregnancy. 38
29254409 2019
11
Early second-trimester plasma cell free DNA levels with subsequent risk of pregnancy complications. 38
31278894 2019
12
Maternal HBsAg carriers and adverse pregnancy outcomes: A hospital-based prospective cohort analysis. 38
30972911 2019
13
Assessment of Mechanical Fetal PR Interval in Intrahepatic Cholestasis of Pregnancy and Its Relationship with the Severity of the Disease. 38
31430816 2019
14
Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. 38
31378395 2019
15
Intrahepatic Cholestasis of Pregnancy: A Case Study of the Rare Onset in the First Trimester. 38
31404990 2019
16
PITCHing ursodeoxycholic acid in intrahepatic cholestasis of pregnancy versus placebo. 38
31431728 2019
17
Inflammatory marker YKL-40 levels in intrahepatic cholestasis of pregnancy. 38
30688121 2019
18
Women successfully treated for severe intrahepatic cholestasis of pregnancy do not have increased risks for adverse perinatal outcomes. 38
31277130 2019
19
Familial intrahepatic cholestasis: New and wide perspectives. 38
31105019 2019
20
Digestive Disease Week 2019. 38
31258315 2019
21
Intrahepatic cholestasis of pregnancy and comorbidity: A 44-year follow-up study. 38
31355915 2019
22
Total serum bile acids or serum bile acid profile, or both, for the diagnosis of intrahepatic cholestasis of pregnancy. 38
31283001 2019
23
Perinatal outcomes of intrahepatic cholestasis of pregnancy in twin versus singleton pregnancies: is plurality associated with adverse outcomes? 38
31346701 2019
24
Liver Disease in Pregnancy and Transplant. 38
31346820 2019
25
The urinary bile acid profiling analysis of asymptomatic hypercholanemia of pregnancy: A pseudo-targeted metabolomics study. 38
31276634 2019
26
Ursodeoxycholic acid inhibits uptake and vasoconstrictor effects of taurocholate in human placenta. 38
30922127 2019
27
Population Scale Retrospective Analysis Reveals Potential Risk of Cholestasis in Pregnant Women Taking Omeprazole, Lansoprazole, and Amoxicillin. 38
31106388 2019
28
Characteristics of bile acids metabolism profile in the second and third trimesters of normal pregnancy. 38
30959040 2019
29
Long-term survival after intrahepatic cholestasis of pregnancy: A follow-up of 571 mothers. 38
31247486 2019
30
Specific dermatoses of pregnancy other than pemphigoid gestationis. 38
30375214 2019
31
The biochemical diagnosis of intrahepatic cholestasis of pregnancy. 38
31217811 2019
32
Targeting FXR in Cholestasis. 38
31201556 2019
33
Thiopurine hepatotoxicity can mimic intrahepatic cholestasis of pregnancy. 38
31109900 2019
34
Increased levels of the novel hepatokine fetuin B in patients with intrahepatic cholestasis of pregnancy. 38
29233036 2019
35
Intrahepatic Cholestasis of Pregnancy as a Clinical Manifestation of Sodium-Taurocholate Cotransporting Polypeptide Deficiency. 38
31142693 2019
36
Relations of neuropeptide Y and heme oxygenase-1 expressions with fetal brain injury in rats with intrahepatic cholestasis of pregnancy. 38
31066785 2019
37
Liver Enzyme Elevation in Pregnant Women Receiving Antiretroviral Therapy in the ANRS-French Perinatal Cohort. 38
30702449 2019
38
Early Onset Intrahepatic Cholestasis of Pregnancy: Is Progesterone Supplementation to be Blamed For? 38
30956477 2019
39
Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of inflammatory cytokines and fetal outcomes. 38
30936968 2019
40
Diagnosis and prognosis of early-onset intrahepatic cholestasis of pregnancy: a prospective study. 38
29065754 2019
41
ABCB4/MDR3 in health and disease - at the crossroads of biochemistry and medicine. 38
30730833 2019
42
Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. 38
30773280 2019
43
Correlation of lipid peroxidation and ATP enzyme on erythrocyte membrane with fetal distress in the uterus in patients with intrahepatic cholestasis of pregnancy. 38
30964154 2019
44
Adjuvant Use of Rifampin for Refractory Intrahepatic Cholestasis of Pregnancy. 38
30681532 2019
45
Waveform analysis of the fetal ECG in labor in patients with intrahepatic cholestasis of pregnancy. 38
30203501 2019
46
Lithocholic acid activates mTOR signaling inducing endoplasmic reticulum stress in placenta during intrahepatic cholestasis of pregnancy. 38
30605648 2019
47
Predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy with dichorionic diamniotic twin pregnancies. 38
29020816 2019
48
Biliary transporter gene mutations in severe intrahepatic cholestasis of pregnancy: Diagnostic and management implications. 38
29992621 2019
49
Association between bile salt export pump polymorphisms and intrahepatic cholestasis of pregnancy susceptibility: a meta-analysis of case-control studies. 38
30614300 2019
50
Celastrol Attenuates Intrahepatic Cholestasis of Pregnancy by Inhibiting Matrix Metalloproteinases-2 and 9. 38
31113607 2019

Variations for Intrahepatic Cholestasis of Pregnancy

Expression for Intrahepatic Cholestasis of Pregnancy

Search GEO for disease gene expression data for Intrahepatic Cholestasis of Pregnancy.

Pathways for Intrahepatic Cholestasis of Pregnancy

Pathways related to Intrahepatic Cholestasis of Pregnancy according to KEGG:

37
# Name Kegg Source Accession
1 Bile secretion hsa04976

Pathways related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.96 SLCO1B3 SLCO1A2 NR1H4 ABCC3 ABCB11
2
Show member pathways
11.87 SLCO1A2 ABCC2 ABCB4 ABCB11
3
Show member pathways
11.76 SLCO1B3 SLCO1A2 ABCC2 ABCB11
4
Show member pathways
11.69 NR1I3 NR1I2 NR1H4 ESR2
5 11.56 SLCO1B3 SLCO1A2 NR1H4 ABCC3 ABCC2 ABCB4
6
Show member pathways
11.49 NR1I3 NR1I2 ABCC2
7 11.14 NR1I3 ABCC3 ABCC2
8 10.92 ABCC3 ABCC2
9
Show member pathways
10.86 SLCO1B3 SLCO1A2 ABCC3 ABCC2
10 10.82 NR1H4 ABCB4 ABCB11
11 10.8 ABCC3 ABCC2
12 10.71 NR1I2 ABCC3
13 10.71 NR1I3 NR1I2 NR1H4 ABCC3 ABCC2 ABCB4
14 10.66 NR1I3 NR1I2 NR1H4 ABCC3 ABCC2 ABCB11
15 10.52 ABCC3 ABCC2
16 10.34 UCN CRHR2

GO Terms for Intrahepatic Cholestasis of Pregnancy

Cellular components related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.56 SLCO1B3 SLCO1A2 CRHR2 ATP8B1 ABCC3 ABCC2
2 RNA polymerase II transcription factor complex GO:0090575 9.33 NR1I3 NR1I2 NR1H4
3 intercellular canaliculus GO:0046581 8.8 ABCC2 ABCB4 ABCB11

Biological processes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.73 SLCO1B3 SLCO1A2 ABCC3 ABCC2 ABCB4 ABCB11
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.67 NR1I3 NR1I2 NR1H4 ESR2
3 steroid hormone mediated signaling pathway GO:0043401 9.58 NR1I3 NR1I2 NR1H4
4 phospholipid translocation GO:0045332 9.51 ATP8B1 ABCB4
5 intracellular receptor signaling pathway GO:0030522 9.5 NR1I3 NR1I2 NR1H4
6 sodium-independent organic anion transport GO:0043252 9.49 SLCO1B3 SLCO1A2
7 bile acid metabolic process GO:0008206 9.48 NR1H4 ATP8B1
8 organic anion transport GO:0015711 9.46 SLCO1B3 SLCO1A2
9 drug transmembrane transport GO:0006855 9.16 ATP8B1 ABCC2
10 xenobiotic transport GO:0042908 9.13 NR1I2
11 canalicular bile acid transport GO:0015722 9.13 ABCC3 ABCC2 ABCB11
12 bile acid and bile salt transport GO:0015721 9.1 SLCO1B3 SLCO1A2 NR1H4 ATP8B1 ABCC3 ABCB11

Molecular functions related to Intrahepatic Cholestasis of Pregnancy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.83 NR1I3 NR1I2 NR1H4 ENPP2
2 transcription coactivator activity GO:0003713 9.8 NR1I3 NR1I2 NR1H4 ESR2
3 ATPase activity GO:0016887 9.76 ABCC3 ABCC2 ABCB4 ABCB11
4 transcription regulatory region sequence-specific DNA binding GO:0000976 9.61 NR1I3 NR1I2 NR1H4
5 nuclear receptor transcription coactivator activity GO:0030374 9.58 NR1I3 NR1I2 NR1H4
6 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.56 ABCC3 ABCC2 ABCB4 ABCB11
7 sodium-independent organic anion transmembrane transporter activity GO:0015347 9.51 SLCO1B3 SLCO1A2
8 bile acid transmembrane transporter activity GO:0015125 9.48 SLCO1B3 SLCO1A2
9 steroid hormone receptor activity GO:0003707 9.46 NR1I3 NR1I2 NR1H4 ESR2
10 bile acid-exporting ATPase activity GO:0015432 9.37 ABCC3 ABCB11
11 bile acid receptor activity GO:0038181 9.32 NR1H4 GPBAR1
12 nuclear receptor activity GO:0004879 9.26 NR1I3 NR1I2 NR1H4 ESR2
13 organic anion transmembrane transporter activity GO:0008514 8.92 SLCO1B3 SLCO1A2 ABCC3 ABCC2

Sources for Intrahepatic Cholestasis of Pregnancy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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