MCID: INT014
MIFTS: 28

Intrahepatic Gall Duct Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Intrahepatic Gall Duct Cancer

MalaCards integrated aliases for Intrahepatic Gall Duct Cancer:

Name: Intrahepatic Gall Duct Cancer 12 15
Malignant Neoplasm of Intrahepatic Gall Duct 12 71
Malignant Neoplasm of Intrahepatic Biliary Passages 12
Malignant Neoplasm of Intrahepatic Bile Ducts 12
Ca Intrahepatic Bile Ducts 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12298
ICD9CM 34 155.1
SNOMED-CT 67 93840005
UMLS 71 C0546835

Summaries for Intrahepatic Gall Duct Cancer

MalaCards based summary : Intrahepatic Gall Duct Cancer, also known as malignant neoplasm of intrahepatic gall duct, is related to neurenteric cyst and cryptogenic cirrhosis. An important gene associated with Intrahepatic Gall Duct Cancer is SARS2 (Seryl-TRNA Synthetase 2, Mitochondrial), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include breast, liver and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Intrahepatic Gall Duct Cancer

Diseases related to Intrahepatic Gall Duct Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 neurenteric cyst 10.3 KRT8 KRT18
2 cryptogenic cirrhosis 10.3 KRT8 KRT18
3 idiopathic corneal edema 10.3 KRT8 KRT19
4 melon allergy 10.3 SARS2 ALB
5 sweat gland neoplasm 10.2 KRT8 KRT7
6 cervical intraepithelial neoplasia 10.2 KRT8 KRT17
7 endolymphatic sac tumor 10.2 KRT8 KRT7
8 subareolar duct papillomatosis 10.2 KRT8 KRT7
9 nipple neoplasm 10.2 KRT8 KRT7
10 large cell acanthoma 10.2 KRT7 KRT17
11 synovium neoplasm 10.2 KRT8 KRT7
12 ovarian endometrial cancer 10.2 SARS2 KRT7
13 epithelioid cell synovial sarcoma 10.2 SARS2 KRT7
14 intrahepatic bile duct adenoma 10.2 KRT7 KRT19
15 bile duct adenoma 10.2 KRT7 KRT19
16 warthin tumor 10.2 KRT7 KRT18
17 renal pelvis adenocarcinoma 10.2 KRT7 KRT19
18 lung clear cell carcinoma 10.2 KRT7 KRT18
19 apocrine sweat gland neoplasm 10.2 KRT8 KRT7
20 mediastinum sarcoma 10.2 KRT7 KRT19
21 epithelioid trophoblastic tumor 10.2 KRT7 KRT18
22 anal canal adenocarcinoma 10.2 KRT7 KRT19
23 keratinizing squamous cell carcinoma 10.2 KRT8 KRT7
24 lipoadenoma 10.2 KRT7 KRT19
25 breast osteosarcoma 10.1 KRT8 KRT7
26 cribriform carcinoma 10.1 KRT8 KRT7
27 ovarian germ cell teratoma 10.1 KRT7 KRT19
28 eccrine sweat gland cancer 10.1 KRT7 KRT19
29 glomangiomatosis 10.1 PTPRC KRT18
30 cerebrovascular benign neoplasm 10.1 KRT7 KRT18
31 benign mesenchymoma 10.1 KRT7 KRT19
32 biliary tract benign neoplasm 10.1 KRT7 KRT19
33 borst-jadassohn intraepidermal carcinoma 10.1 KRT7 KRT17
34 sarcomatous intrahepatic cholangiocarcinoma 10.1 KRT7 KRT19
35 renal adenoma 10.1 KRT7 KRT19
36 pulmonary artery leiomyosarcoma 10.1 KRT7 KRT19
37 central epithelioid sarcoma 10.1 KRT7 KRT18
38 nasal cavity olfactory neuroblastoma 10.1 KRT7 KRT19
39 vulvar proximal-type epithelioid sarcoma 10.1 KRT7 KRT18
40 metanephric adenoma 10.1 KRT7 KRT18
41 diclofenac allergy 10.1 PTPRC ALB
42 monophasic synovial sarcoma 10.1 KRT7 KRT19
43 adenofibroma 10.1 KRT7 KRT19
44 syringoma 10.1 KRT7 KRT19
45 sweat gland disease 10.0 KRT8 KRT7
46 odontoma 10.0 KRT8 KRT19 KRT18
47 epididymis adenocarcinoma 10.0 PTPRC KRT7
48 epididymis cancer 10.0 PTPRC KRT7
49 prostate neuroendocrine neoplasm 10.0 PTPRC KRT7
50 mediastinal cancer 10.0 PTPRC KRT7

Comorbidity relations with Intrahepatic Gall Duct Cancer via Phenotypic Disease Network (PDN):


Cholangitis Cholestasis
Deficiency Anemia Hepatocellular Carcinoma

Graphical network of the top 20 diseases related to Intrahepatic Gall Duct Cancer:



Diseases related to Intrahepatic Gall Duct Cancer

Symptoms & Phenotypes for Intrahepatic Gall Duct Cancer

GenomeRNAi Phenotypes related to Intrahepatic Gall Duct Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.7 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.7 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.7 KRT18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.7 KRT8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.7 KRT7
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.7 KRT18 KRT7 KRT8
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.7 KRT7
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.7 KRT18
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.7 KRT7
10 Reduced mammosphere formation GR00396-S 9.02 ALB DDX41 KRT18 KRT7 PTPRC

MGI Mouse Phenotypes related to Intrahepatic Gall Duct Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 ALB EPCAM KRT17 KRT19 KRT8 PTPRC
2 mortality/aging MP:0010768 9.28 ALB CSNK2A1 DDX41 EPCAM KRT17 KRT18

Drugs & Therapeutics for Intrahepatic Gall Duct Cancer

Search Clinical Trials , NIH Clinical Center for Intrahepatic Gall Duct Cancer

Genetic Tests for Intrahepatic Gall Duct Cancer

Anatomical Context for Intrahepatic Gall Duct Cancer

MalaCards organs/tissues related to Intrahepatic Gall Duct Cancer:

40
Breast, Liver, Lung, Eye, Lymph Node, Kidney, Skin

Publications for Intrahepatic Gall Duct Cancer

Variations for Intrahepatic Gall Duct Cancer

Expression for Intrahepatic Gall Duct Cancer

Search GEO for disease gene expression data for Intrahepatic Gall Duct Cancer.

Pathways for Intrahepatic Gall Duct Cancer

Pathways related to Intrahepatic Gall Duct Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 PTPRC KRT8 KRT7 KRT19 KRT18 KRT17
2
Show member pathways
12.01 KRT8 KRT7 KRT19 KRT18 KRT17
3 11.92 KRT8 KRT7 KRT19 KRT18 KRT17 EPCAM
4 11.67 KRT19 EPCAM ALB
5 11.48 KRT19 KRT18 KRT17
6
Show member pathways
11.05 KRT8 KRT7 KRT19 KRT18 KRT17
7 10.95 KRT8 KRT19

GO Terms for Intrahepatic Gall Duct Cancer

Cellular components related to Intrahepatic Gall Duct Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 PTPRC KRT8 KRT7 KRT19 KRT18 KRT17
2 keratin filament GO:0045095 9.43 KRT8 KRT7 KRT18
3 apicolateral plasma membrane GO:0016327 9.4 KRT8 KRT19
4 costamere GO:0043034 9.37 KRT8 KRT19
5 intermediate filament GO:0005882 9.35 KRT8 KRT7 KRT19 KRT18 KRT17
6 dystrophin-associated glycoprotein complex GO:0016010 9.32 KRT8 KRT19
7 cell periphery GO:0071944 9.02 PTPRC KRT8 KRT19 KRT18 KRT17

Biological processes related to Intrahepatic Gall Duct Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.67 KRT8 KRT7 KRT19 KRT18
2 sarcomere organization GO:0045214 9.4 KRT8 KRT19
3 keratinization GO:0031424 9.35 KRT8 KRT7 KRT19 KRT18 KRT17
4 positive regulation of stem cell proliferation GO:2000648 9.32 PTPRC EPCAM
5 hepatocyte apoptotic process GO:0097284 9.26 KRT8 KRT18
6 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT8 KRT19
7 cornification GO:0070268 9.02 KRT8 KRT7 KRT19 KRT18 KRT17

Molecular functions related to Intrahepatic Gall Duct Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding involved in cell-cell adhesion GO:0098641 8.62 KRT18 EPCAM

Sources for Intrahepatic Gall Duct Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....