MCID: INT014
MIFTS: 25

Intrahepatic Gall Duct Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Intrahepatic Gall Duct Cancer

MalaCards integrated aliases for Intrahepatic Gall Duct Cancer:

Name: Intrahepatic Gall Duct Cancer 12 15
Malignant Neoplasm of Intrahepatic Gall Duct 12 71
Malignant Neoplasm of Intrahepatic Biliary Passages 12
Malignant Neoplasm of Intrahepatic Bile Ducts 12
Ca Intrahepatic Bile Ducts 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12298
ICD9CM 34 155.1
SNOMED-CT 67 187777008
UMLS 71 C0546835

Summaries for Intrahepatic Gall Duct Cancer

MalaCards based summary : Intrahepatic Gall Duct Cancer, also known as malignant neoplasm of intrahepatic gall duct, is related to prostate stromal sarcoma and neurenteric cyst. An important gene associated with Intrahepatic Gall Duct Cancer is SARS2 (Seryl-TRNA Synthetase 2, Mitochondrial), and among its related pathways/superpathways are Developmental Biology and Keratinization. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Intrahepatic Gall Duct Cancer

Diseases related to Intrahepatic Gall Duct Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 prostate stromal sarcoma 10.3 KRT8 CSNK2A1
2 neurenteric cyst 10.3 KRT8 KRT18
3 idiopathic corneal edema 10.2 KRT8 KRT19
4 cryptogenic cirrhosis 10.2 KRT8 KRT18
5 morpheaform basal cell carcinoma 10.2 KRT19 KRT17
6 adhesive otitis media 10.2 KRT8 KRT18
7 cervical intraepithelial neoplasia 10.2 KRT8 KRT17
8 melon allergy 10.2 SARS2 ALB
9 endolymphatic sac tumor 10.1 KRT8 KRT7
10 subareolar duct papillomatosis 10.1 KRT8 KRT7
11 nipple benign neoplasm 10.1 KRT8 KRT7
12 benign breast adenomyoepithelioma 10.1 KRT8 KRT7
13 large cell acanthoma 10.1 KRT7 KRT17
14 acanthoma 10.1 KRT7 KRT17
15 synovium neoplasm 10.1 KRT8 KRT7
16 lung clear cell carcinoma 10.1 KRT7 KRT18
17 iodine hypothyroidism 10.1 DDX41 ALB
18 apocrine sweat gland neoplasm 10.1 KRT8 KRT7
19 breast osteosarcoma 10.1 KRT8 KRT7
20 epithelioid sarcoma 10.0 KRT8 KRT7
21 intrahepatic bile duct adenoma 10.0 KRT7 KRT19
22 bile duct adenoma 10.0 KRT7 KRT19
23 warthin tumor 10.0 KRT7 KRT18
24 cribriform carcinoma 10.0 KRT8 KRT7
25 borst-jadassohn intraepidermal carcinoma 10.0 KRT7 KRT17
26 epithelioid trophoblastic tumor 10.0 KRT7 KRT18
27 renal pelvis adenocarcinoma 10.0 KRT7 KRT19
28 vulvar apocrine adenocarcinoma 10.0 KRT7 KRT19
29 anal canal adenocarcinoma 10.0 KRT7 KRT19
30 lipoadenoma 10.0 KRT7 KRT19
31 central epithelioid sarcoma 10.0 KRT7 KRT18
32 pericardium cancer 10.0 KRT7 KRT19
33 vulvar proximal-type epithelioid sarcoma 10.0 KRT7 KRT18
34 pulmonary artery leiomyosarcoma 10.0 KRT7 KRT19
35 eccrine sweat gland cancer 10.0 KRT7 KRT19
36 esophageal adenosquamous carcinoma 10.0 KRT7 KRT18
37 biliary tract benign neoplasm 10.0 KRT7 KRT19
38 ovarian germ cell teratoma 10.0 KRT7 KRT19
39 nasal cavity olfactory neuroblastoma 10.0 KRT7 KRT19
40 sweat gland benign neoplasm 10.0 KRT8 KRT7
41 mixed fibrolamellar hepatocellular carcinoma 10.0 KRT7 KRT19
42 bile duct cysts 10.0 KRT7 KRT19
43 struma ovarii 10.0 KRT7 KRT19
44 metanephric adenoma 10.0 KRT7 KRT18
45 ovarian germ cell cancer 10.0 KRT7 KRT19
46 monophasic synovial sarcoma 10.0 KRT7 KRT19
47 sweat gland disease 10.0 KRT8 KRT7
48 odontoma 9.9 KRT8 KRT19 KRT18
49 syringoma 9.9 KRT7 KRT19
50 adenofibroma 9.9 KRT7 KRT19

Comorbidity relations with Intrahepatic Gall Duct Cancer via Phenotypic Disease Network (PDN):


Cholangitis Cholestasis
Deficiency Anemia Hepatocellular Carcinoma

Graphical network of the top 20 diseases related to Intrahepatic Gall Duct Cancer:



Diseases related to Intrahepatic Gall Duct Cancer

Symptoms & Phenotypes for Intrahepatic Gall Duct Cancer

GenomeRNAi Phenotypes related to Intrahepatic Gall Duct Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-124 9.32 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-127 9.32 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.32 KRT18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.32 KRT18
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.32 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.32 KRT18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.32 KRT18 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.32 KRT18

MGI Mouse Phenotypes related to Intrahepatic Gall Duct Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 ALB EPCAM KRT17 KRT19 KRT8
2 mortality/aging MP:0010768 9.23 ALB CSNK2A1 DDX41 EPCAM KRT17 KRT18

Drugs & Therapeutics for Intrahepatic Gall Duct Cancer

Search Clinical Trials , NIH Clinical Center for Intrahepatic Gall Duct Cancer

Genetic Tests for Intrahepatic Gall Duct Cancer

Anatomical Context for Intrahepatic Gall Duct Cancer

Publications for Intrahepatic Gall Duct Cancer

Variations for Intrahepatic Gall Duct Cancer

Expression for Intrahepatic Gall Duct Cancer

Search GEO for disease gene expression data for Intrahepatic Gall Duct Cancer.

Pathways for Intrahepatic Gall Duct Cancer

Pathways related to Intrahepatic Gall Duct Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 KRT8 KRT7 KRT19 KRT18 KRT17 CSNK2A1
2
Show member pathways
12.01 KRT8 KRT7 KRT19 KRT18 KRT17
3 11.92 KRT8 KRT7 KRT19 KRT18 KRT17 EPCAM
4 11.67 KRT19 EPCAM ALB
5 11.42 KRT19 KRT18 KRT17
6
Show member pathways
11.05 KRT8 KRT7 KRT19 KRT18 KRT17
7 10.95 KRT8 KRT19

GO Terms for Intrahepatic Gall Duct Cancer

Cellular components related to Intrahepatic Gall Duct Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.88 KRT8 KRT7 KRT19 KRT18 EPCAM ALB
2 apicolateral plasma membrane GO:0016327 9.37 KRT8 KRT19
3 keratin filament GO:0045095 9.33 KRT8 KRT7 KRT18
4 costamere GO:0043034 9.32 KRT8 KRT19
5 dystrophin-associated glycoprotein complex GO:0016010 9.26 KRT8 KRT19
6 cell periphery GO:0071944 9.26 KRT8 KRT19 KRT18 KRT17
7 intermediate filament GO:0005882 9.02 KRT8 KRT7 KRT19 KRT18 KRT17

Biological processes related to Intrahepatic Gall Duct Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.62 KRT8 KRT7 KRT19 KRT18
2 extrinsic apoptotic signaling pathway GO:0097191 9.4 KRT8 KRT18
3 sarcomere organization GO:0045214 9.37 KRT8 KRT19
4 keratinization GO:0031424 9.35 KRT8 KRT7 KRT19 KRT18 KRT17
5 hepatocyte apoptotic process GO:0097284 9.26 KRT8 KRT18
6 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT8 KRT19
7 cornification GO:0070268 9.02 KRT8 KRT7 KRT19 KRT18 KRT17

Molecular functions related to Intrahepatic Gall Duct Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 KRT19 KRT18 KRT17
2 cadherin binding involved in cell-cell adhesion GO:0098641 8.62 KRT18 EPCAM

Sources for Intrahepatic Gall Duct Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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