MCID: INT004
MIFTS: 27

Intraneural Perineurioma

Categories: Cancer diseases, Muscle diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Intraneural Perineurioma

MalaCards integrated aliases for Intraneural Perineurioma:

Name: Intraneural Perineurioma 11 19 58 14 71 75

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 11 DOID:4696
NCIt 49 C6911
SNOMED-CT 68 768934004
UMLS via Orphanet 72 C1370658
Orphanet 58 ORPHA100003
UMLS 71 C1370658

Summaries for Intraneural Perineurioma

GARD: 19 Intraneural perineurioma is a rare tumor of cranial and spinal nerves arising from peripheral nerve sheath and composed exclusively or predominantly of cells showing perineurial differentiation. It presents as a localized, tubular or fusiform enlargement of a nerve or nerve segment, usually in the extremities or the trunk, associated with a motor-predominant mononeuropathy including slow, painless, gradual loss of motor function in the involved nerve trunk with muscle weakness and atrophy and, rarely, sensory dysfunction. Cranial nerve involvement is rare.

MalaCards based summary: Intraneural Perineurioma is related to perineurioma and neurofibromatosis, type ii. An important gene associated with Intraneural Perineurioma is DCAF8 (DDB1 And CUL4 Associated Factor 8). Affiliated tissues include tongue, colon and skin, and related phenotype is Increased shRNA abundance (Z-score > 2).

Orphanet: 58 Intraneural perineurioma is a rare tumor of cranial and spinal nerves arising from peripheral nerve sheath and composed exclusively or predominantly of cells showing perineurial differentiation. It presents as a localized, tubular or fusiform enlargement of a nerve or nerve segment, usually in the extremities or the trunk, associated with a motor-predominant mononeuropathy including slow, painless, gradual loss of motor function in the involved nerve trunk with muscle weakness and atrophy and, rarely, sensory dysfunction. Cranial nerve involvement is rare.

Wikipedia: 75 An intraneural perineurioma is a rare benign tumor within the sheath of a single nerve that grows but... more...

Related Diseases for Intraneural Perineurioma

Diseases related to Intraneural Perineurioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 perineurioma 31.2 SLC2A1 NF2 DCAF8 CD34
2 neurofibromatosis, type ii 30.6 TRAF7 NF2
3 neurilemmoma 30.6 SOX10 NF2 CD34
4 neurilemmomatosis 30.3 SOX10 NF2
5 neurofibroma 30.2 SOX10 NF2 CD34
6 peripheral nervous system disease 29.5 SOX10 SLC2A1 NF2 DCAF8 CD34
7 meningioma, familial 29.5 TRAF7 SOX10 SLC2A1 NF2 CD34
8 localized hypertrophic neuropathy 10.4
9 mononeuropathy 10.4
10 acoustic neuroma 10.4
11 neuropathy 10.4
12 neurofibromatosis 10.4
13 extraneural perineurioma 10.4
14 carpal tunnel syndrome 10.3
15 mononeuropathy of the median nerve, mild 10.3
16 benign peripheral nerve sheath tumor 10.3
17 sphenoorbital meningioma 10.3 TRAF7 NF2
18 foramen magnum meningioma 10.3 TRAF7 NF2
19 childhood meningioma 10.2 TRAF7 NF2
20 cavernous sinus meningioma 10.2 TRAF7 NF2
21 cerebral falx meningioma 10.2 TRAF7 NF2
22 tuberculum sellae meningioma 10.2 TRAF7 NF2
23 parasagittal meningioma 10.2 TRAF7 NF2
24 microcystic meningioma 10.2 TRAF7 NF2
25 intraventricular meningioma 10.2 TRAF7 NF2
26 sella turcica neoplasm 10.2 TRAF7 NF2
27 cerebral convexity meningioma 10.2 TRAF7 NF2
28 optic nerve sheath meningioma 10.2 TRAF7 NF2
29 olfactory groove meningioma 10.2 TRAF7 NF2
30 anterior cranial fossa meningioma 10.2 TRAF7 NF2
31 petroclival meningioma 10.2 TRAF7 NF2
32 brain meningioma 10.2 TRAF7 NF2
33 transitional meningioma 10.2 TRAF7 NF2
34 secretory meningioma 10.2 TRAF7 NF2
35 rhabdoid meningioma 10.2 TRAF7 NF2
36 skull base meningioma 10.2 TRAF7 NF2
37 spinal canal and spinal cord meningioma 10.2 TRAF7 NF2
38 spinal meningioma 10.2 TRAF7 NF2
39 meningothelial meningioma 10.2 TRAF7 NF2
40 cerebral meningioma 10.2 TRAF7 NF2
41 skull base cancer 10.2 TRAF7 NF2
42 neuritis 10.2
43 rare tumor 10.2
44 spinal cancer 10.2 TRAF7 NF2
45 atypical neurofibroma 10.2 SOX10 NF2
46 melanotic neurilemmoma 10.2 SOX10 NF2
47 facial nerve disease 10.2 NF2 DCAF8
48 facial paralysis 10.2 NF2 DCAF8
49 central nervous system fibrosarcoma 10.1 NF2 CD34
50 lung meningioma 10.1 NF2 CD34

Graphical network of the top 20 diseases related to Intraneural Perineurioma:



Diseases related to Intraneural Perineurioma

Symptoms & Phenotypes for Intraneural Perineurioma

GenomeRNAi Phenotypes related to Intraneural Perineurioma according to GeneCards Suite gene sharing:

25 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.55 NDUFB2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-112 9.55 TRAF4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.55 SOX10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.55 NDUFB2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.55 NDUFB2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.55 SOX10
7 Increased shRNA abundance (Z-score > 2) GR00366-A-18 9.55 SOX10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-216 9.55 TRAF4
9 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.55 NDUFB2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.55 TRAF4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.55 SOX10 TRAF4
12 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.55 TRAF4
13 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.55 SOX10
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.55 SOX10
15 Increased shRNA abundance (Z-score > 2) GR00366-A-87 9.55 TRAF4
16 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.55 SOX10

Drugs & Therapeutics for Intraneural Perineurioma

Search Clinical Trials, NIH Clinical Center for Intraneural Perineurioma

Genetic Tests for Intraneural Perineurioma

Anatomical Context for Intraneural Perineurioma

Organs/tissues related to Intraneural Perineurioma:

MalaCards : Tongue, Colon, Skin

Publications for Intraneural Perineurioma

Articles related to Intraneural Perineurioma:

(show top 50) (show all 89)
# Title Authors PMID Year
1
A Rare case of Ulnar Nerve Intraneural Perineurioma in an elderly gentleman. 62
35330746 2022
2
Perineurioma: A Rare Entity of Peripheral Nerve Sheath Tumors. 62
34030186 2022
3
Intraneural perineurioma with thenar atrophy presenting as congenital absence of thenar muscles. 62
32790117 2021
4
Nerve conduction assessment and magnetic resonance imaging for the diagnosis of localized hypertrophic neuropathy of the sciatic nerve and the lumbo-sacral plexus. 62
34507126 2021
5
Clinical Features, Natural History, and Outcomes of Intraneural Perineuriomas: A Systematic Review of the Literature. 62
34284162 2021
6
Hybrid Schwannoma/Perineurioma: Morphologic Variations and Genetic Profiles. 62
33337633 2021
7
Intraneural perineurioma of the median nerve at the elbow: A clinical case. 62
33640519 2021
8
[Intraneural perineurioma of the radial nerve in the spiral canal as the cause of a 6-year progressive paresis of hand and finger extension]. 62
32910223 2020
9
Facial Nerve Intraneural Perineurioma Masquerading as a Schwannoma. 62
32857124 2020
10
Intraneural perineurioma of the mandible: case series of a rare entity. 62
32868253 2020
11
Association of intraneural perineurioma with neurofibromatosis type 2. 62
32529330 2020
12
Intraneural perineurioma in neurofibromatosis type 2 with molecular analysis. 62
32271143 2020
13
[Informative value of ultrasound in the diagnosis of intraneural perineurioma]. 62
33095535 2020
14
Clinical and Radiological Follow-up of Intraneural Perineuriomas. 62
30481319 2019
15
Clinicoradiological features of intraneural perineuriomas obviate the need for tissue diagnosis. 62
29192862 2018
16
Perineurioma of the colon: an uncommon tumor with an unusual location. Report of a case and review of the literature. 62
30546148 2018
17
Intraosseous intraneural perineurioma derived from the inferior alveolar nerve with an abnormality of chromosome 22 and expression of the BCR-ABL fusion gene: report of a case and review of recent literature. 62
30213264 2018
18
Intraneural perineuriomas: diagnostic value of magnetic resonance neurography. 62
29094786 2018
19
Intraneural perineurioma: a retrospective study of 19 patients. 62
30637060 2018
20
Anesthesia for a parturient with intraneural perineurioma: A case report. 62
29245354 2017
21
Oral perineurioma: clinicopathologic features from two cases and review of literature. 62
28034640 2017
22
Teaching NeuroImages: Sonographic detection of intraneural perineurioma in therapy-refractory carpal tunnel syndrome. 62
28265045 2017
23
Can Intraneural Perineuriomas Occur Intradurally? An Anatomic Perspective. 62
28173435 2017
24
Intratemporal Intraneural Perineurioma of the Facial Nerve. 62
27668794 2016
25
Intraneural perineurioma of the digital nerve: a case report. 62
26115680 2016
26
Diagnosis and outcome of childhood perineurioma. 62
27086131 2016
27
Case report: Intraneural perineurioma of the sciatic nerve in an adolescent - strategies for revealing the diagnosis. 62
27525083 2016
28
Nerve ultrasound and 3D-MR neurography suggestive of intraneural perineurioma. 62
27001989 2016
29
[Sciatic nerve intraneural perineurioma]. 62
26586011 2015
30
Case report of bilateral relapsing-remitting sciatic nerve palsy during two pregnancies. 62
26545719 2015
31
The almost-invisible perineurioma. 62
26323815 2015
32
Intraneural perineurioma of the skin. 62
24999546 2015
33
[A rare tumor of the median nerve in a young child: Intraneural perineurioma. About one clinical case]. 62
24041664 2014
34
Surgical removal of intraneural perineurioma arising in the brachial plexus using an interfascicular dissection technique. 62
24883285 2014
35
Fibrolipomatous hamartoma of the nerve: a clinicopathologic report of 13 cases. 62
24480457 2014
36
Microscopic intraneural perineurial cell proliferations in patients with neurofibromatosis type 1. 62
24461704 2014
37
Distinctive manifestations of cutaneous intraneural perineurioma of fingers, compared with typical intraneural perineurioma. 62
24685866 2014
38
Hemi-body port-wine stains and progressive paresis due to territorial perineuriomas. 62
24092235 2014
39
Intraneural perineurioma of the sciatic nerve: an under-recognized nerve neoplasm with characteristic MRI findings. 62
24061494 2014
40
Intraneural malignant perineurioma: a case report and review of literature. 62
25120842 2014
41
Intraneural perineurioma affecting multiple nerves: a case report and literature review. 62
25031759 2014
42
Intraneural perineurioma arising in the lateral border of the tongue. 62
24422960 2013
43
Intraneural perineurioma of unilateral radial and median nerves manifesting with long-standing focal amyotrophy in a 14-year-old-boy. 62
24263031 2013
44
Hybrid schwannoma/perineurioma of the spinal nerve: multifocal occurrence, and recurrence as an intraneural perineurioma. 62
23865576 2013
45
Cutaneous intraneural perineurioma: a case report. 62
23221470 2013
46
MRI in hypertrophic mono- and polyneuropathies. 62
22959851 2013
47
Mini-invasive robot-assisted surgery of the brachial plexus: a case of intraneural perineurioma. 62
22638873 2012
48
Claudin-1 and glucose transporter 1 immunolabelling in a canine intraneural perineurioma. 62
22297071 2012
49
MRI of intraneural perineurioma of the brachial plexus. 62
27326273 2012
50
An unusual location of ulnar nerve pathology: a perineurioma of the ulnar nerve in the upper arm. 62
21922473 2011

Variations for Intraneural Perineurioma

Expression for Intraneural Perineurioma

Search GEO for disease gene expression data for Intraneural Perineurioma.

Pathways for Intraneural Perineurioma

GO Terms for Intraneural Perineurioma

Biological processes related to Intraneural Perineurioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of Schwann cell proliferation GO:0010626 8.92 SOX10 NF2

Sources for Intraneural Perineurioma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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