MCID: INT004
MIFTS: 35

Intraneural Perineurioma

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Intraneural Perineurioma

MalaCards integrated aliases for Intraneural Perineurioma:

Name: Intraneural Perineurioma 12 53 59 15 73

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4696
NCIt 50 C6911
SNOMED-CT 68 128795001
Orphanet 59 ORPHA100003
UMLS via Orphanet 74 C1370658
UMLS 73 C1370658

Summaries for Intraneural Perineurioma

MalaCards based summary : Intraneural Perineurioma is related to perineurioma and localized hypertrophic neuropathy. An important gene associated with Intraneural Perineurioma is SLC2A1 (Solute Carrier Family 2 Member 1), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include tongue and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 An intraneural perineurioma is a rare benign tumor within the sheath of a single nerve that grows but... more...

Related Diseases for Intraneural Perineurioma

Diseases related to Intraneural Perineurioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 perineurioma 32.5 MUC1 S100B SLC2A1
2 localized hypertrophic neuropathy 31.5 MUC1 S100B
3 sclerosing perineurioma 11.0 MUC1 S100B
4 intracranial cysts 11.0 MUC1 S100B
5 reticular perineurioma 11.0 MUC1 S100B
6 malignant iris melanoma 11.0 S100A1 S100B
7 eosinophilic variant of chromophobe renal cell carcinoma 11.0 S100A1 SLC2A1
8 non-functioning pituitary adenoma 11.0 MUC1 S100B
9 ossifying fibromyxoid tumor 10.9 MUC1 S100B
10 papillary tumor of the pineal region 10.9 MUC1 S100A1
11 fibrous meningioma 10.9 MUC1 S100B
12 chordoid meningioma 10.9 MUC1 S100B
13 syringocystadenoma papilliferum 10.9 MUC1 S100B
14 eccrine porocarcinoma 10.9 MUC1 S100B
15 spindle cell rhabdomyosarcoma 10.9 MUC1 S100B
16 frontal sinus inverted papilloma 10.8 KRT13 KRT5
17 solid adenocarcinoma with mucin production 10.8 KRT7 MUC1
18 frontal sinus cancer 10.8 KRT13 KRT5
19 aggressive digital papillary adenocarcinoma 10.8 MUC1 S100B
20 basal cell carcinoma, infundibulocystic 10.8 KRT10 KRT14
21 polymorphous low-grade adenocarcinoma 10.8 MUC1 S100A1 S100B
22 neurenteric cyst 10.8 KRT18 KRT8
23 ameloblastic carcinoma 10.8 KRT14 SLC2A1
24 endosalpingiosis 10.8 KRT7 MUC1
25 parachordoma 10.8 KRT7 MUC1
26 epidermolysis bullosa simplex, autosomal recessive 1 10.8 KRT14 KRT5
27 epidermolysis bullosa simplex, localized 10.7 KRT14 KRT5
28 myxopapillary ependymoma 10.7 MUC1 S100B
29 pleomorphic liposarcoma 10.7 KRT8 MUC1 S100B
30 malignant mixed mullerian tumor 10.7 KRT7 MUC1
31 lichen planopilaris 10.7 KRT14 KRT5
32 mucinous bronchioloalveolar adenocarcinoma 10.7 KRT7 MUC1
33 endolymphatic sac tumor 10.7 KRT7 KRT8
34 malignant triton tumor 10.7 NF1 S100B
35 primary cutaneous anaplastic large cell lymphoma 10.7 ALK MUC1
36 pleomorphic adenoma 10.7 KRT14 MUC1 S100B
37 alk-positive anaplastic large cell lymphoma 10.7 ALK MUC1
38 bile duct cystadenocarcinoma 10.7 KRT7 MUC1
39 inverted transitional papilloma 10.7 KRT5 KRT7
40 balloon cell malignant melanoma 10.6 KRT5 KRT7
41 monophasic synovial sarcoma 10.6 KRT7 MUC1 S100B
42 oncocytic breast carcinoma 10.6 KRT14 KRT7
43 spindle cell sarcoma 10.6 KRT7 MUC1 S100B
44 orbital granuloma 10.6 CD34 MUC1
45 malignant spiradenoma 10.6 KRT5 KRT7
46 sensory organ benign neoplasm 10.6 KRT5 KRT7
47 transitional papilloma 10.6 KRT13 KRT18 SOX10
48 nodular hidradenoma 10.6 KRT10 KRT7 MUC1
49 epithelioid trophoblastic tumor 10.6 KRT18 KRT7
50 cavernous hemangioma 10.6 KRT14 KRT18 MUC1

Graphical network of the top 20 diseases related to Intraneural Perineurioma:



Diseases related to Intraneural Perineurioma

Symptoms & Phenotypes for Intraneural Perineurioma

GenomeRNAi Phenotypes related to Intraneural Perineurioma according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.58 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.58 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.58 KRT5 KRT18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.58 KRT8 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.58 KRT5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.58 KRT18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.58 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.58 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.58 KRT7 KRT8 KRT18 KRT5
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.58 KRT7
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.58 KRT18
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.58 KRT7 KRT5

MGI Mouse Phenotypes related to Intraneural Perineurioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.56 S100B SOX10 ALK CD34 KRT14 KRT19
2 neoplasm MP:0002006 9.1 NF1 SOX10 ALK CD34 KRT14 KRT19

Drugs & Therapeutics for Intraneural Perineurioma

Search Clinical Trials , NIH Clinical Center for Intraneural Perineurioma

Genetic Tests for Intraneural Perineurioma

Anatomical Context for Intraneural Perineurioma

MalaCards organs/tissues related to Intraneural Perineurioma:

41
Tongue, Skin

Publications for Intraneural Perineurioma

Articles related to Intraneural Perineurioma:

(show all 45)
# Title Authors Year
1
Teaching NeuroImages: Sonographic detection of intraneural perineurioma in therapy-refractory carpal tunnel syndrome. ( 28265045 )
2017
2
Anesthesia for a parturient with intraneural perineurioma: A case report. ( 29245354 )
2017
3
Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas. ( 28019650 )
2017
4
Intratemporal Intraneural Perineurioma of the Facial Nerve. ( 27668794 )
2016
5
Nerve ultrasound and 3D-MR neurography suggestive of intraneural perineurioma. ( 27001989 )
2016
6
Case report: Intraneural perineurioma of the sciatic nerve in an adolescent - strategies for revealing the diagnosis. ( 27525083 )
2016
7
Intraneural perineurioma of the digital nerve: a case report. ( 26115680 )
2015
8
Surgical removal of intraneural perineurioma arising in the brachial plexus using an interfascicular dissection technique. ( 24883285 )
2014
9
Intraneural Perineurioma of the Skin. ( 24999546 )
2014
10
Intraneural perineurioma affecting multiple nerves: a case report and literature review. ( 25031759 )
2014
11
Distinctive manifestations of cutaneous intraneural perineurioma of fingers, compared with typical intraneural perineurioma. ( 24685866 )
2014
12
Cutaneous intraneural perineurioma: a case report. ( 23221470 )
2013
13
Hybrid schwannoma/perineurioma of the spinal nerve: multifocal occurrence, and recurrence as an intraneural perineurioma. ( 23865576 )
2013
14
Intraneural perineurioma of the sciatic nerve: An under-recognized nerve neoplasm with characteristic MRI findings. ( 24061494 )
2013
15
Intraneural perineurioma arising in the lateral border of the tongue. ( 24422960 )
2013
16
Intraneural perineurioma of unilateral radial and median nerves manifesting with long-standing focal amyotrophy in a 14-year-old-boy. ( 24263031 )
2013
17
MRI of intraneural perineurioma of the brachial plexus. ( 27326273 )
2012
18
Mini-invasive robot-assisted surgery of the brachial plexus: a case of intraneural perineurioma. ( 22638873 )
2012
19
Claudin-1 and glucose transporter 1 immunolabelling in a canine intraneural perineurioma. ( 22297071 )
2012
20
Intraneural perineurioma of the median nerve: case report and literature review. ( 19876692 )
2010
21
A case of intraneural perineurioma presenting with monomelic atrophy in a child. ( 20004070 )
2010
22
Oral intraneural perineurioma. Report of two cases. ( 19841714 )
2009
23
Longitudinal study of intraneural perineurioma--a benign, focal hypertrophic neuropathy of youth. ( 19567701 )
2009
24
Intraneural perineurioma of the sciatic nerve in early childhood. ( 19520281 )
2009
25
Intraneural perineurioma. ( 19766004 )
2009
26
Re: intraneural perineurioma of the median nerve. A rare cause of carpal tunnel syndrome. ( 18332033 )
2008
27
Intraneural perineurioma of the radial nerve visualized by 3.0 Tesla MRI. ( 17471567 )
2007
28
Intraneural perineurioma of the VIIIth cranial nerve: case report. ( 17881938 )
2007
29
Intraneural perineurioma of the oral mucosa. ( 16757071 )
2007
30
Multiple orofacial intraneural perineuriomas in a patient with hemifacial hyperplasia. ( 17449293 )
2007
31
Intraneural perineurioma: a systematic review with illustrative cases. ( 17824794 )
2007
32
Intraneural perineurioma of the third cranial nerve: occurrence and identification. Case report. ( 16703891 )
2006
33
Canine intraneural perineurioma. ( 16407486 )
2006
34
Intraneural perineurioma of the tongue: a case report. ( 16781350 )
2006
35
Intraneural perineurioma in a child with Beckwith-Wiedemann syndrome. ( 15750909 )
2005
36
Intraneural perineurioma of the radial nerve in a child. ( 16039379 )
2005
37
Intraosseous intraneural perineurioma: report of a case with morphological, immunohistochemical and FISH study. ( 14704619 )
2004
38
Radial nerve palsy owing to localized hypertrophic neuropathy (intraneural perineurioma) in early childhood. ( 15032391 )
2004
39
Bilateral intraneural perineurioma presenting as ulnar neuropathy at the elbow. ( 15266642 )
2004
40
Intraneural perineurioma involving the ulnar nerve. ( 15086844 )
2004
41
Intraneural perineurioma--not restricted to major nerves. ( 12931092 )
2003
42
Carpal tunnel syndrome due to an intraneural perineurioma in a 2-year-old child. ( 11281674 )
2001
43
Intraneural perineurioma of the common peroneal nerve. Case report and review of the literature. ( 11354415 )
2001
44
Intraneural perineurioma involving the median nerve. ( 10839408 )
2000
45
Intraneural perineurioma. A clonal neoplasm associated with abnormalities of chromosome 22. ( 7785653 )
1995

Variations for Intraneural Perineurioma

Expression for Intraneural Perineurioma

Search GEO for disease gene expression data for Intraneural Perineurioma.

Pathways for Intraneural Perineurioma

Pathways related to Intraneural Perineurioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 KRT10 KRT13 KRT14 KRT18 KRT19 KRT5
2 12.25 KRT10 KRT13 KRT18 KRT19 KRT5 KRT7
3
Show member pathways
12.01 KRT10 KRT13 KRT14 KRT18 KRT19 KRT5
4 11.4 S100B SLC2A1 SOX10
5
Show member pathways
11.2 KRT13 KRT14 KRT18 KRT19 KRT5 KRT7

GO Terms for Intraneural Perineurioma

Cellular components related to Intraneural Perineurioma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 9.67 KRT19 KRT8 S100A1 SLC2A1
2 sarcolemma GO:0042383 9.58 KRT19 KRT8 SLC2A1
3 apicolateral plasma membrane GO:0016327 9.49 KRT19 KRT8
4 costamere GO:0043034 9.48 KRT19 KRT8
5 dystrophin-associated glycoprotein complex GO:0016010 9.46 KRT19 KRT8
6 cell periphery GO:0071944 9.46 CD34 KRT18 KRT19 KRT8
7 keratin filament GO:0045095 9.43 KRT13 KRT14 KRT18 KRT5 KRT7 KRT8
8 intermediate filament GO:0005882 9.23 KRT10 KRT13 KRT14 KRT18 KRT19 KRT5
9 nucleus GO:0005634 10.25 KRT10 KRT13 KRT14 KRT18 KRT5 KRT7
10 cytoplasm GO:0005737 10.2 ALK CD34 KRT10 KRT14 KRT18 KRT5
11 extracellular exosome GO:0070062 10 ALK KRT10 KRT13 KRT14 KRT18 KRT19

Biological processes related to Intraneural Perineurioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.56 KRT10 KRT13 KRT14 KRT18 KRT19 KRT5
2 positive regulation of myelination GO:0031643 9.37 S100B SOX10
3 hemidesmosome assembly GO:0031581 9.32 KRT14 KRT5
4 hepatocyte apoptotic process GO:0097284 9.26 KRT18 KRT8
5 cornification GO:0070268 9.23 KRT10 KRT13 KRT14 KRT18 KRT19 KRT5
6 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT19 KRT8

Molecular functions related to Intraneural Perineurioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.43 KRT14 KRT19 KRT5
2 S100 protein binding GO:0044548 9.16 S100A1 S100B
3 scaffold protein binding GO:0097110 9.13 KRT18 KRT5 KRT8
4 structural molecule activity GO:0005198 9.02 KRT10 KRT13 KRT18 KRT7 KRT8

Sources for Intraneural Perineurioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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