Intraneural Perineurioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Intraneural Perineurioma

MalaCards integrated aliases for Intraneural Perineurioma:

Name: Intraneural Perineurioma ¹¹ ¹⁹ ⁵⁸ ¹⁴ ⁷¹ ⁷⁵

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Neuronal diseases Muscle diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare neurological diseases

External Ids:

Disease Ontology ¹¹ DOID:4696

NCIt ⁴⁹ C6911

SNOMED-CT ⁶⁸ 768934004

UMLS via Orphanet ⁷² C1370658

Orphanet ⁵⁸ ORPHA100003

UMLS ⁷¹ C1370658

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Summaries for Intraneural Perineurioma

GARD: ¹⁹ Intraneural perineurioma is a rare tumor of cranial and spinal nerves arising from peripheral nerve sheath and composed exclusively or predominantly of cells showing perineurial differentiation. It presents as a localized, tubular or fusiform enlargement of a nerve or nerve segment, usually in the extremities or the trunk, associated with a motor-predominant mononeuropathy including slow, painless, gradual loss of motor function in the involved nerve trunk with muscle weakness and atrophy and, rarely, sensory dysfunction. Cranial nerve involvement is rare.

MalaCards based summary: Intraneural Perineurioma is related to perineurioma and neurofibromatosis, type ii. An important gene associated with Intraneural Perineurioma is DCAF8 (DDB1 And CUL4 Associated Factor 8). Affiliated tissues include tongue, colon and skin, and related phenotype is Increased shRNA abundance (Z-score > 2).

Orphanet: ⁵⁸ Intraneural perineurioma is a rare tumor of cranial and spinal nerves arising from peripheral nerve sheath and composed exclusively or predominantly of cells showing perineurial differentiation. It presents as a localized, tubular or fusiform enlargement of a nerve or nerve segment, usually in the extremities or the trunk, associated with a motor-predominant mononeuropathy including slow, painless, gradual loss of motor function in the involved nerve trunk with muscle weakness and atrophy and, rarely, sensory dysfunction. Cranial nerve involvement is rare.

Wikipedia: ⁷⁵ An intraneural perineurioma is a rare benign tumor within the sheath of a single nerve that grows but... more...

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Related Diseases for Intraneural Perineurioma

Diseases related to Intraneural Perineurioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)

#	Related Disease	Score	Top Affiliating Genes
1	perineurioma	31.2	SLC2A1 NF2 DCAF8 CD34
2	neurofibromatosis, type ii	30.6	TRAF7 NF2
3	neurilemmoma	30.6	SOX10 NF2 CD34
4	neurilemmomatosis	30.3	SOX10 NF2
5	neurofibroma	30.2	SOX10 NF2 CD34
6	peripheral nervous system disease	29.5	SOX10 SLC2A1 NF2 DCAF8 CD34
7	meningioma, familial	29.5	TRAF7 SOX10 SLC2A1 NF2 CD34
8	localized hypertrophic neuropathy	10.4
9	mononeuropathy	10.4
10	acoustic neuroma	10.4
11	neuropathy	10.4
12	neurofibromatosis	10.4
13	extraneural perineurioma	10.4
14	carpal tunnel syndrome	10.3
15	mononeuropathy of the median nerve, mild	10.3
16	benign peripheral nerve sheath tumor	10.3
17	sphenoorbital meningioma	10.3	TRAF7 NF2
18	foramen magnum meningioma	10.3	TRAF7 NF2
19	childhood meningioma	10.2	TRAF7 NF2
20	cavernous sinus meningioma	10.2	TRAF7 NF2
21	cerebral falx meningioma	10.2	TRAF7 NF2
22	tuberculum sellae meningioma	10.2	TRAF7 NF2
23	parasagittal meningioma	10.2	TRAF7 NF2
24	microcystic meningioma	10.2	TRAF7 NF2
25	intraventricular meningioma	10.2	TRAF7 NF2
26	sella turcica neoplasm	10.2	TRAF7 NF2
27	cerebral convexity meningioma	10.2	TRAF7 NF2
28	optic nerve sheath meningioma	10.2	TRAF7 NF2
29	olfactory groove meningioma	10.2	TRAF7 NF2
30	anterior cranial fossa meningioma	10.2	TRAF7 NF2
31	petroclival meningioma	10.2	TRAF7 NF2
32	brain meningioma	10.2	TRAF7 NF2
33	transitional meningioma	10.2	TRAF7 NF2
34	secretory meningioma	10.2	TRAF7 NF2
35	rhabdoid meningioma	10.2	TRAF7 NF2
36	skull base meningioma	10.2	TRAF7 NF2
37	spinal canal and spinal cord meningioma	10.2	TRAF7 NF2
38	spinal meningioma	10.2	TRAF7 NF2
39	meningothelial meningioma	10.2	TRAF7 NF2
40	cerebral meningioma	10.2	TRAF7 NF2
41	skull base cancer	10.2	TRAF7 NF2
42	neuritis	10.2
43	rare tumor	10.2
44	spinal cancer	10.2	TRAF7 NF2
45	atypical neurofibroma	10.2	SOX10 NF2
46	melanotic neurilemmoma	10.2	SOX10 NF2
47	facial nerve disease	10.2	NF2 DCAF8
48	facial paralysis	10.2	NF2 DCAF8
49	central nervous system fibrosarcoma	10.1	NF2 CD34
50	lung meningioma	10.1	NF2 CD34

Graphical network of the top 20 diseases related to Intraneural Perineurioma:

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Symptoms & Phenotypes for Intraneural Perineurioma

GenomeRNAi Phenotypes related to Intraneural Perineurioma according to GeneCards Suite gene sharing:

²⁵ (show all 16)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-111	9.55	NDUFB2
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-112	9.55	TRAF4
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.55	SOX10
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-124	9.55	NDUFB2
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	9.55	NDUFB2
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.55	SOX10
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-18	9.55	SOX10
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-216	9.55	TRAF4
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-23	9.55	NDUFB2
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.55	TRAF4
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	9.55	SOX10 TRAF4
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-77	9.55	TRAF4
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	9.55	SOX10
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.55	SOX10
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-87	9.55	TRAF4
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-91	9.55	SOX10

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Drugs & Therapeutics for Intraneural Perineurioma

Search Clinical Trials, NIH Clinical Center for Intraneural Perineurioma

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Genetic Tests for Intraneural Perineurioma

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Anatomical Context for Intraneural Perineurioma

Organs/tissues related to Intraneural Perineurioma:

MalaCards : Tongue, Colon, Skin

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Publications for Intraneural Perineurioma

Articles related to Intraneural Perineurioma:

(show top 50) (show all 89)

#	Title	Authors	PMID	Year
1	A Rare case of Ulnar Nerve Intraneural Perineurioma in an elderly gentleman. ⁶²	Kelly T...Findlay M	35330746	2022
2	Perineurioma: A Rare Entity of Peripheral Nerve Sheath Tumors. ⁶²	Brand C...Antoniadis G	34030186	2022
3	Intraneural perineurioma with thenar atrophy presenting as congenital absence of thenar muscles. ⁶²	Pendleton C...Spinner RJ	32790117	2021
4	Nerve conduction assessment and magnetic resonance imaging for the diagnosis of localized hypertrophic neuropathy of the sciatic nerve and the lumbo-sacral plexus. ⁶²	Jafari R...Javanbakht M	34507126	2021
5	Clinical Features, Natural History, and Outcomes of Intraneural Perineuriomas: A Systematic Review of the Literature. ⁶²	Lenartowicz KA...Spinner RJ	34284162	2021
6	Hybrid Schwannoma/Perineurioma: Morphologic Variations and Genetic Profiles. ⁶²	Hirose T...Jimbo N	33337633	2021
7	Intraneural perineurioma of the median nerve at the elbow: A clinical case. ⁶²	Hery JC...Hulet C	33640519	2021
8	[Intraneural perineurioma of the radial nerve in the spiral canal as the cause of a 6-year progressive paresis of hand and finger extension]. ⁶²	Klippel E...Heinen C	32910223	2020
9	Facial Nerve Intraneural Perineurioma Masquerading as a Schwannoma. ⁶²	Manzoor NF...Haynes DS	32857124	2020
10	Intraneural perineurioma of the mandible: case series of a rare entity. ⁶²	Ko E...Alawi F	32868253	2020
11	Association of intraneural perineurioma with neurofibromatosis type 2. ⁶²	Pendleton C...Klein CJ	32529330	2020
12	Intraneural perineurioma in neurofibromatosis type 2 with molecular analysis. ⁶²	White B...Rodriguez FJ	32271143	2020
13	[Informative value of ultrasound in the diagnosis of intraneural perineurioma]. ⁶²	Druzhinin DS...Nikitin SS	33095535	2020
14	Clinical and Radiological Follow-up of Intraneural Perineuriomas. ⁶²	Wilson TJ...Spinner RJ	30481319	2019
15	Clinicoradiological features of intraneural perineuriomas obviate the need for tissue diagnosis. ⁶²	Wilson TJ...Amrami KK	29192862	2018
16	Perineurioma of the colon: an uncommon tumor with an unusual location. Report of a case and review of the literature. ⁶²	Motta F...Magro G	30546148	2018
17	Intraosseous intraneural perineurioma derived from the inferior alveolar nerve with an abnormality of chromosome 22 and expression of the BCR-ABL fusion gene: report of a case and review of recent literature. ⁶²	Kurihara J...Seki M	30213264	2018
18	Intraneural perineuriomas: diagnostic value of magnetic resonance neurography. ⁶²	Leon Cejas L...Reisin R	29094786	2018
19	Intraneural perineurioma: a retrospective study of 19 patients. ⁶²	Alkhaili J...Belkheyar Z	30637060	2018
20	Anesthesia for a parturient with intraneural perineurioma: A case report. ⁶²	Li J...Wang J	29245354	2017
21	Oral perineurioma: clinicopathologic features from two cases and review of literature. ⁶²	Gomes da Silva W...Pires FR	28034640	2017
22	Teaching NeuroImages: Sonographic detection of intraneural perineurioma in therapy-refractory carpal tunnel syndrome. ⁶²	Krogias C...Uerschels AK	28265045	2017
23	Can Intraneural Perineuriomas Occur Intradurally? An Anatomic Perspective. ⁶²	Prasad NK...Spinner RJ	28173435	2017
24	Intratemporal Intraneural Perineurioma of the Facial Nerve. ⁶²	Hunter JB...Dinces E	27668794	2016
25	Intraneural perineurioma of the digital nerve: a case report. ⁶²	Visser NJ...van Loon J	26115680	2016
26	Diagnosis and outcome of childhood perineurioma. ⁶²	McMillan HJ...Bourque PR	27086131	2016
27	Case report: Intraneural perineurioma of the sciatic nerve in an adolescent - strategies for revealing the diagnosis. ⁶²	Dahlin LB...Backman C	27525083	2016
28	Nerve ultrasound and 3D-MR neurography suggestive of intraneural perineurioma. ⁶²	Salvalaggio A...Briani C	27001989	2016
29	[Sciatic nerve intraneural perineurioma]. ⁶²	Bonhomme B...Lepreux S	26586011	2015
30	Case report of bilateral relapsing-remitting sciatic nerve palsy during two pregnancies. ⁶²	Suntrup-Krueger S...Meuth SG	26545719	2015
31	The almost-invisible perineurioma. ⁶²	Restrepo CE...Spinner RJ	26323815	2015
32	Intraneural perineurioma of the skin. ⁶²	Leblebici C...Demirkesen C	24999546	2015
33	[A rare tumor of the median nerve in a young child: Intraneural perineurioma. About one clinical case]. ⁶²	Ridel P...Duteille F	24041664	2014
34	Surgical removal of intraneural perineurioma arising in the brachial plexus using an interfascicular dissection technique. ⁶²	Chung JH...Han SK	24883285	2014
35	Fibrolipomatous hamartoma of the nerve: a clinicopathologic report of 13 cases. ⁶²	Plaza JA...Sangueza M	24480457	2014
36	Microscopic intraneural perineurial cell proliferations in patients with neurofibromatosis type 1. ⁶²	Agaimy A	24461704	2014
37	Distinctive manifestations of cutaneous intraneural perineurioma of fingers, compared with typical intraneural perineurioma. ⁶²	Chin SY...Lee WR	24685866	2014
38	Hemi-body port-wine stains and progressive paresis due to territorial perineuriomas. ⁶²	Howe BM...Spinner RJ	24092235	2014
39	Intraneural perineurioma of the sciatic nerve: an under-recognized nerve neoplasm with characteristic MRI findings. ⁶²	Nacey NC...Gaskin CM	24061494	2014
40	Intraneural malignant perineurioma: a case report and review of literature. ⁶²	Huang Y...Chen R	25120842	2014
41	Intraneural perineurioma affecting multiple nerves: a case report and literature review. ⁶²	Wang LM...Pan Y	25031759	2014
42	Intraneural perineurioma arising in the lateral border of the tongue. ⁶²	Hirano M...Tanuma J	24422960	2013
43	Intraneural perineurioma of unilateral radial and median nerves manifesting with long-standing focal amyotrophy in a 14-year-old-boy. ⁶²	Nagappa M...Taly AB	24263031	2013
44	Hybrid schwannoma/perineurioma of the spinal nerve: multifocal occurrence, and recurrence as an intraneural perineurioma. ⁶²	Hayashi T...Kishikawa M	23865576	2013
45	Cutaneous intraneural perineurioma: a case report. ⁶²	Santos-Briz A...Mentzel T	23221470	2013
46	MRI in hypertrophic mono- and polyneuropathies. ⁶²	De Smet K...De Mey J	22959851	2013
47	Mini-invasive robot-assisted surgery of the brachial plexus: a case of intraneural perineurioma. ⁶²	Lequint T...Liverneaux P	22638873	2012
48	Claudin-1 and glucose transporter 1 immunolabelling in a canine intraneural perineurioma. ⁶²	Cornelis I...Van Ham L	22297071	2012
49	MRI of intraneural perineurioma of the brachial plexus. ⁶²	Lavi ES...Norenberg MD	27326273	2012
50	An unusual location of ulnar nerve pathology: a perineurioma of the ulnar nerve in the upper arm. ⁶²	Groeneweg AJ...Visser LH	21922473	2011

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Genes for Intraneural Perineurioma

Genes related to Intraneural Perineurioma (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DCAF8	DDB1 And CUL4 Associated Factor 8	Protein Coding	8.26	DISEASES inferred ¹⁴ ¹⁴
2	TRAF7	TNF Receptor Associated Factor 7	Protein Coding	7.19	DISEASES inferred ¹⁴
3	NF2	NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor	Protein Coding	5.88	DISEASES inferred ¹⁴
4	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	5.66	DISEASES inferred ¹⁴
5	SOX10	SRY-Box Transcription Factor 10	Protein Coding	5.06	DISEASES inferred ¹⁴
6	CCDC183	Coiled-Coil Domain Containing 183	Protein Coding	4.93	DISEASES inferred ¹⁴
7	TMEM141	Transmembrane Protein 141	Protein Coding	4.93	DISEASES inferred ¹⁴
8	NDUFB2	NADH:Ubiquinone Oxidoreductase Subunit B2	Protein Coding	4.9	DISEASES inferred ¹⁴
9	TRAF4	TNF Receptor Associated Factor 4	Protein Coding	4.76	DISEASES inferred ¹⁴
10	ZNF839	Zinc Finger Protein 839	Protein Coding	4.73	DISEASES inferred ¹⁴
11	CD34	CD34 Molecule	Protein Coding	4.66	DISEASES inferred ¹⁴

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Variations for Intraneural Perineurioma

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Expression for Intraneural Perineurioma

Search GEO for disease gene expression data for Intraneural Perineurioma.

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Pathways for Intraneural Perineurioma

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GO Terms for Intraneural Perineurioma

Biological processes related to Intraneural Perineurioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of Schwann cell proliferation	GO:0010626	8.92	SOX10 NF2

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Sources for Intraneural Perineurioma

¹ BitterDB

² CDC

³ Cell Signaling Technology

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⁵ ClinVar

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¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

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⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: INT004 MIFTS: 27	Intraneural Perineurioma Categories: Cancer diseases, Muscle diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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