MCID: INT082
MIFTS: 34

Intraocular Retinoblastoma

Categories: Neuronal diseases, Cancer diseases, Eye diseases

Aliases & Classifications for Intraocular Retinoblastoma

MalaCards integrated aliases for Intraocular Retinoblastoma:

Name: Intraocular Retinoblastoma 12 15 73
Pediatric Intraocular Retinoblastoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4653
NCIt 50 C7846
UMLS 73 C0278717

Summaries for Intraocular Retinoblastoma

Disease Ontology : 12 A retinoblastoma that is located in the eye and has not spread to other parts of the body.

MalaCards based summary : Intraocular Retinoblastoma, also known as pediatric intraocular retinoblastoma, is related to pediatric intraocular retinoblastoma and unilateral retinoblastoma. An important gene associated with Intraocular Retinoblastoma is ESCO2 (Establishment Of Sister Chromatid Cohesion N-Acetyltransferase 2). The drugs Etoposide and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include the eye, eye and liver, and related phenotype is nervous system.

Related Diseases for Intraocular Retinoblastoma

Diseases related to Intraocular Retinoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 pediatric intraocular retinoblastoma 12.4
2 unilateral retinoblastoma 10.9 GREM2 RBL1
3 sc phocomelia syndrome 10.9 ESCO2 SATB2
4 small cell osteogenic sarcoma 10.8 ENO2 SATB2
5 retinoblastoma 10.8
6 accommodative esotropia 10.7 GREM2 KANTR
7 auditory agnosia 10.7 GREM2 KANTR
8 ureter small cell carcinoma 10.6 ENO2 SYP
9 malignant sertoli cell tumor 10.6 ENO2 SYP
10 urinary bladder small cell neuroendocrine carcinoma 10.6 ENO2 SYP
11 auditory system cancer 10.6 ENO2 SYP
12 sinonasal undifferentiated carcinoma 10.6 ENO2 SYP
13 sensory organ benign neoplasm 10.6 ENO2 SYP
14 gallbladder small cell carcinoma 10.6 ENO2 SYP
15 pancreatic somatostatinoma 10.6 ENO2 SYP
16 cutaneous ganglioneuroma 10.6 ENO2 SYP
17 extrahepatic bile duct adenocarcinoma 10.6 ENO2 SYP
18 small cell carcinoma of the bladder 10.6 ENO2 SYP
19 papillary tumor of the pineal region 10.6 ENO2 SYP
20 orbital cancer 10.6 ENO2 SYP
21 middle ear adenoma 10.6 ENO2 SYP
22 ovarian carcinosarcoma 10.6 ENO2 SYP
23 pulmonary large cell neuroendocrine carcinoma 10.6 ENO2 SYP
24 atypical follicular adenoma 10.6 ENO2 SYP
25 central nervous system primitive neuroectodermal neoplasm 10.6 ENO2 SYP
26 cerebellum cancer 10.6 ENO2 SYP
27 subependymal glioma 10.6 ENO2 SYP
28 olfactory nerve neoplasm 10.6 ENO2 SYP
29 cerebral neuroblastoma 10.5 ENO2 SYP
30 cauda equina neoplasm 10.5 ENO2 SYP
31 extraosseous chondrosarcoma 10.5 ENO2 SYP
32 benign ependymoma 10.5 ENO2 SYP
33 malignant teratoma 10.5 ENO2 SYP
34 astroblastoma 10.5 ENO2 SYP
35 cerebral ventricle cancer 10.5 ENO2 SYP
36 cerebrum cancer 10.5 ENO2 SYP
37 pineal gland cancer 10.5 ENO2 SYP
38 endometrial small cell carcinoma 10.5 ENO2 SYP
39 melanotic neuroectodermal tumor 10.5 ENO2 SYP
40 nodular ganglioneuroblastoma 10.5 ENO2 SYP
41 supratentorial cancer 10.5 ENO2 SYP
42 pineocytoma 10.5 ENO2 SYP
43 respiratory system benign neoplasm 10.5 ENO2 SYP
44 angiomyoma 10.5 ENO2 SYP
45 gastric squamous cell carcinoma 10.5 ENO2 SYP
46 gastric small cell carcinoma 10.5 ENO2 SYP
47 desmoplastic small round cell tumor 10.5 ENO2 SYP
48 subependymoma 10.5 ENO2 SYP
49 carcinoid tumors, intestinal 10.5 ENO2 SYP
50 bone benign neoplasm 10.5 ENO2 SYP

Graphical network of the top 20 diseases related to Intraocular Retinoblastoma:



Diseases related to Intraocular Retinoblastoma

Symptoms & Phenotypes for Intraocular Retinoblastoma

MGI Mouse Phenotypes related to Intraocular Retinoblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.28 CRX ENO2 ESCO2 MDM4 PVALB RBL1

Drugs & Therapeutics for Intraocular Retinoblastoma

Drugs for Intraocular Retinoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
2
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 498142 38904
3
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
4
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
5
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
6
Mesna Approved, Investigational Phase 3,Phase 2,Phase 1 3375-50-6 598
7
Topotecan Approved, Investigational Phase 3,Phase 2,Not Applicable 119413-54-6, 123948-87-8 60700
8
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
9
Iodine Approved, Investigational Phase 3,Phase 2,Phase 1 7553-56-2 807
10
Doxil Approved June 1999 Phase 3,Phase 2 31703
11 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
12 Etoposide phosphate Phase 3,Phase 2,Phase 1,Not Applicable
13 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
14 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
15 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
16 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
17 cadexomer iodine Phase 3,Phase 2,Phase 1
18 Alkylating Agents Phase 3,Phase 2,Phase 1
19 topoisomerase I inhibitors Phase 3,Phase 2,Not Applicable
20 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1
21 Micronutrients Phase 3,Phase 2
22 Trace Elements Phase 3,Phase 2
23 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
24 Antibiotics, Antitubercular Phase 3,Phase 2
25 Anti-Infective Agents, Local Phase 3,Phase 2
26 Antirheumatic Agents Phase 3,Phase 2
27 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
28 Anesthetics Phase 3
29
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
30
Thiotepa Approved, Investigational Phase 2,Phase 1 52-24-4 5453
31
Arsenic trioxide Approved, Investigational Phase 2 1327-53-3 518740
32
Menthol Approved Phase 2 2216-51-5 16666
33
Dexamethasone Approved, Investigational, Vet_approved Phase 2,Phase 1 50-02-2 5743
34
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
35
Acetaminophen Approved Phase 2 103-90-2 1983
36
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
37
Melphalan Approved Phase 2,Phase 1 148-82-3 4053 460612
38
Promethazine Approved, Investigational Phase 2 60-87-7 4927
39 Antibodies Phase 2,Phase 1
40 Immunoglobulins Phase 2,Phase 1
41 Antibodies, Monoclonal Phase 2,Phase 1
42 Liver Extracts Phase 2,Phase 1
43 Dexamethasone acetate Phase 2,Phase 1 1177-87-3
44 BB 1101 Phase 2,Phase 1
45 Cyclosporins Phase 2
46 Dermatologic Agents Phase 2
47 Antifungal Agents Phase 2
48 Calcineurin Inhibitors Phase 2
49
Neomycin Approved, Vet_approved Phase 1 1404-04-2 8378
50
Mechlorethamine Approved, Investigational Phase 1 51-75-2 4033

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Neoadjuvant Carboplatin and Vincristine and Standard Local Ophthalmic Therapy in Treating Patients With Intraocular Retinoblastoma Completed NCT00079417 Phase 3 carboplatin;vincristine sulfate
2 Systemic Vincristine, Carboplatin, and Etoposide, Subtenon Carboplatin, and Local Ophthalmic Therapy in Treating Children With Intraocular Retinoblastoma Completed NCT00072384 Phase 3 liposomal vincristine sulfate;carboplatin;etoposide
3 Vincristine, Carboplatin, and Etoposide or Observation Only in Treating Patients Who Have Undergone Surgery for Newly Diagnosed Retinoblastoma Completed NCT00335738 Phase 3 liposomal vincristine sulfate;carboplatin;etoposide
4 Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine + Topotecan;Vincristine + Carboplatin + Etoposide;Vincristine + Cyclophosphamide + Doxorubicin;Vincristine+Carboplatin+Etoposide
5 Chemotherapy in Treating Patients With Retinoblastoma Completed NCT00002675 Phase 2 carboplatin;cisplatin;cyclophosphamide;etoposide;mesna;vincristine sulfate
6 Carboplatin Plus Vincristine in Treating Children With Retinoblastoma Completed NCT00002794 Phase 2 carboplatin;vincristine sulfate
7 Combination Chemotherapy, Radiation Therapy, and Bone Marrow Transplantation in Treating Patients With Retinoblastoma Completed NCT00004006 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;topotecan hydrochloride
8 High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors Completed NCT00003173 Phase 2 thiotepa
9 Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
10 Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00006102 Phase 2 becatecarin
11 Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma Recruiting NCT01783535 Phase 2 vincristine;topotecan;filgrastim;PEG-filgrastim;carboplatin;etoposide;cyclophosphamide;MESNA;doxorubicin
12 Combination Chemotherapy and Cyclosporine Followed by Focal Therapy for Bilateral Retinoblastoma Active, not recruiting NCT00110110 Phase 2 Carboplatin;Cyclosporine;Etoposide;vincristine sulfate
13 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
14 Intra-arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma Terminated NCT01293539 Phase 2 Melphalan hydrochloride
15 Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma Withdrawn NCT01151748 Phase 2
16 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1
17 Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma Recruiting NCT02792036 Phase 1 Carboplatin;Maxitrol®
18 Alternating Systemic Chemotherapy and Intra-Arterial Melphalan Chemotherapy in Children With Intra-Ocular Retinoblastoma Active, not recruiting NCT02116959 Phase 1 Melphalan;Carboplatin;Etoposide;Vincristine
19 MT2004-30: Tomotherapy for Solid Tumors Terminated NCT00623077 Phase 1 busulfan;etoposide;ifosfamide;melphalan;thiotepa;Mesna
20 Trial Comparing Two Carboplatin Doses in Groups C and D Intraocular Retinoblastoma Unknown status NCT00889018 Not Applicable carboplatin;carboplatin
21 Chemotherapy With or Without Radiation Therapy or Observation in Treating Young Patients With Advanced Retinoblastoma Who Have Undergone Surgery to Remove the Eye Unknown status NCT00360750 Not Applicable carboplatin;cytarabine;etoposide;vincristine sulfate
22 Collecting and Storing Tissue From Young Patients With Cancer Recruiting NCT00898755
23 Genetic Mutations and Environmental Exposure in Young Patients With Retinoblastoma and in Their Parents and Young Healthy Unrelated Volunteers Active, not recruiting NCT00690469
24 RCT of Ballon Technique VS Selective Ophthalmic Artery Infusion For the Retinoblastoma Patients Not yet recruiting NCT03439397 Not Applicable
25 Pilot Study of Topotecan/Vincristine With Subconjunctival Carboplatin for Patients With Bilateral Retinoblastoma Withdrawn NCT00980551 Not Applicable subtenon Carboplatin;Topotecan Hydrochloride;Vincristine;Filgrastim

Search NIH Clinical Center for Intraocular Retinoblastoma

Genetic Tests for Intraocular Retinoblastoma

Anatomical Context for Intraocular Retinoblastoma

The Foundational Model of Anatomy Ontology organs/tissues related to Intraocular Retinoblastoma:

19
The Eye

MalaCards organs/tissues related to Intraocular Retinoblastoma:

41
Eye, Liver, Bone, Bone Marrow, Pineal

Publications for Intraocular Retinoblastoma

Articles related to Intraocular Retinoblastoma:

(show top 50) (show all 106)
# Title Authors Year
1
Is a diagnostic lumbar puncture indicated in intraocular retinoblastoma? ( 29676357 )
2018
2
Re: Zhao etA al.: Pars plana vitrectomy and endoresection ofA refractory intraocular retinoblastoma (Ophthalmology. 2018;125:320-322). ( 29935678 )
2018
3
Pars Plana Vitrectomy and Endoresection of Refractory Intraocular Retinoblastoma. ( 29153457 )
2018
4
Managing and treating intraocular retinoblastoma. ( 29915462 )
2018
5
Three presentations of CNS disease in patients with intraocular retinoblastoma at a tertiary medical center in the United States. ( 28949779 )
2017
6
Concomitant Intraocular Retinoblastoma and Choroidal Hemangioma in a 1-Year-Old Boy. ( 28984344 )
2017
7
Unusually very late-onset new growth of intraocular retinoblastoma: A case report and review of literature. ( 29503965 )
2017
8
High-Risk Histopathology Features in Primary and Secondary Enucleated International Intraocular Retinoblastoma Classification Group D Eyes. ( 28302322 )
2017
9
Evolution of Chemotherapy Approaches for the Treatment of Intraocular Retinoblastoma: A Comprehensive Review. ( 27898618 )
2017
10
Necrotic Intraocular Retinoblastoma Associated With Orbital Cellulitis. ( 28254446 )
2017
11
Ocular Salvage and Vision Preservation Using a Topotecan-Based Regimen for Advanced Intraocular Retinoblastoma. ( 28034080 )
2017
12
HIGH-RISK INTRAOCULAR RETINOBLASTOMA: Comparison Between Asian Indians and Americans From Two Major Referral Centers. ( 28834944 )
2017
13
Hemodynamic and Anatomic Variations Require an Adaptable Approach during Intra-Arterial Chemotherapy for Intraocular Retinoblastoma: Alternative Routes, Strategies, and Follow-Up. ( 26915566 )
2016
14
Selective Ophthalmic Artery Infusion Chemotherapy for Advanced Intraocular Retinoblastoma: CCHMC Early Experience. ( 26583615 )
2016
15
Incidence of Orbital Recurrence After Enucleation or Ophthalmic Artery Chemosurgery for Advanced Intraocular Retinoblastoma--Reply. ( 26584063 )
2016
16
Long-term visual outcomes in intraocular retinoblastoma with eye preservation. ( 26781471 )
2016
17
Systemic neoadjuvant chemotherapy for Group B intraocular retinoblastoma (ARET0331): A report from the Children's Oncology Group. ( 28019092 )
2016
18
Incidence of Orbital Recurrence After Enucleation or Ophthalmic Artery Chemosurgery for Advanced Intraocular Retinoblastoma. ( 26583950 )
2016
19
Embryologic Anatomic Variations: Challenges in Intra-Arterial Chemotherapy for Intraocular Retinoblastoma. ( 27469215 )
2016
20
Chemoreduction of Progressive Intraocular Retinoblastoma by Systemic Topotecan. ( 26760494 )
2016
21
Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma. ( 26230335 )
2015
22
Socioeconomic and psychological impact of treatment for unilateral intraocular retinoblastoma. ( 25982424 )
2015
23
Transorbital anastomotic pathways between the external and internal carotid systems in children affected by intraocular retinoblastoma. ( 26198114 )
2015
24
Clinical presentation of intraocular retinoblastoma; 5-year hospital-based registry in Egypt. ( 26490323 )
2015
25
Intravitreal injection of melphalan for intraocular retinoblastoma. ( 25808017 )
2015
26
Alternated intra-arterial and intravitreal chemotherapy for advanced intraocular retinoblastoma: preliminary successful results without systemic chemotherapy. ( 26416040 )
2015
27
Selective ophthalmic arterial injection of melphalan for intraocular retinoblastoma: a 4-year review. ( 25465196 )
2015
28
Enucleation vs Ophthalmic Artery Chemosurgery for Advanced Intraocular Retinoblastoma: A Retrospective Analysis. ( 26181236 )
2015
29
Clinical efficacy and prognostic factors of chemoreduction combined with topical treatment for advanced intraocular retinoblastoma. ( 25292067 )
2014
30
Radiation dose reduction in intra-arterial chemotherapy infusion for intraocular retinoblastoma. ( 24385553 )
2014
31
Superselective ophthalmic artery infusion of melphalan for intraocular retinoblastoma: preliminary results from 140 treatments. ( 22268993 )
2013
32
Intra-arterial chemotherapy with melphalan for intraocular retinoblastoma. ( 23853166 )
2013
33
Carboplatin +/- topotecan ophthalmic artery chemosurgery for intraocular retinoblastoma. ( 23991112 )
2013
34
Salvage/adjuvant brachytherapy after ophthalmic artery chemosurgery for intraocular retinoblastoma. ( 23953635 )
2013
35
Predictors of long-term visual outcome after chemoreduction for management of intraocular retinoblastoma. ( 22300311 )
2012
36
Topotecan and vincristine combination is effective against advanced bilateral intraocular retinoblastoma and has manageable toxicity. ( 22516936 )
2012
37
Zygomatico-orbital intra-arterial melphalan infusion for intraocular retinoblastoma. ( 21990490 )
2012
38
Ophthalmic artery chemosurgery for less advanced intraocular retinoblastoma: five year review. ( 22545080 )
2012
39
A histopathologic analysis of eyes primarily enucleated for advanced intraocular retinoblastoma from a developing country. ( 22288967 )
2012
40
Three-drug intra-arterial chemotherapy using simultaneous carboplatin, topotecan and melphalan for intraocular retinoblastoma: preliminary results. ( 22863945 )
2012
41
Intra-arterial chemotherapy as a treatment for intraocular retinoblastoma: alternatives to direct ophthalmic artery catheterization. ( 22442047 )
2012
42
Second malignant neoplasms following chemoreduction with carboplatin, etoposide, and vincristine in 245 patients with intraocular retinoblastoma. ( 21826785 )
2012
43
Is it pre-enucleation chemotherapy or delayed enucleation of severely involved eyes with intraocular retinoblastoma that risks extraocular dissemination and death? ( 21768467 )
2011
44
Occurrence of sectoral choroidal occlusive vasculopathy and retinal arteriolar embolization after superselective ophthalmic artery chemotherapy for advanced intraocular retinoblastoma. ( 21273941 )
2011
45
Selective ophthalmic artery infusion of chemotherapy for advanced intraocular retinoblastoma: initial experience with 17 tumors. ( 21294621 )
2011
46
Clinical presentation and group classification of newly diagnosed intraocular retinoblastoma in China. ( 21252083 )
2011
47
Clinical characteristics and treatment outcome of children with intraocular retinoblastoma: a report from a Chinese cooperative group. ( 21681922 )
2011
48
A clinicopathological correlation of 67 eyes primarily enucleated for advanced intraocular retinoblastoma. ( 20693555 )
2011
49
Periocular topotecan for intraocular retinoblastoma. ( 21670340 )
2011
50
Selective ophthalmic arterial injection therapy for intraocular retinoblastoma: the long-term prognosis. ( 21715012 )
2011

Variations for Intraocular Retinoblastoma

Expression for Intraocular Retinoblastoma

Search GEO for disease gene expression data for Intraocular Retinoblastoma.

Pathways for Intraocular Retinoblastoma

GO Terms for Intraocular Retinoblastoma

Sources for Intraocular Retinoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
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34 ICD10 via Orphanet
35 ICD9CM
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45 MESH via Orphanet
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49 NCI
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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