MCID: INT082
MIFTS: 30

Intraocular Retinoblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Intraocular Retinoblastoma

MalaCards integrated aliases for Intraocular Retinoblastoma:

Name: Intraocular Retinoblastoma 12 15 70
Pediatric Intraocular Retinoblastoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4653
NCIt 50 C7846
UMLS 70 C0278717 C1321869

Summaries for Intraocular Retinoblastoma

Disease Ontology : 12 A retinoblastoma that is located in the eye and has not spread to other parts of the body.

MalaCards based summary : Intraocular Retinoblastoma, also known as pediatric intraocular retinoblastoma, is related to bilateral retinoblastoma and unilateral retinoblastoma. An important gene associated with Intraocular Retinoblastoma is CRYAA (Crystallin Alpha A). The drugs Iodine and Mesna have been mentioned in the context of this disorder. Affiliated tissues include eye, pineal and retina.

Related Diseases for Intraocular Retinoblastoma

Diseases related to Intraocular Retinoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 bilateral retinoblastoma 30.7 MYCN MDM4
2 unilateral retinoblastoma 30.6 MYCN MDM4
3 extraocular retinoblastoma 30.3 MDM4 BCOR
4 pediatric intraocular retinoblastoma 11.6
5 retinoblastoma 10.9
6 neutropenia 10.3
7 retinal detachment 10.3
8 leukocoria 10.3
9 leber congenital amaurosis 3 10.2 CRYAA CRX
10 cone-rod dystrophy 3 10.1 CRYAA CRX
11 strabismus 10.1
12 neovascular glaucoma 10.1
13 cellulitis 10.1
14 mechanical strabismus 10.1
15 hereditary retinal dystrophy 10.1 CRYAA CRX
16 microphthalmia, syndromic 2 10.1 CRYAA BCOR
17 leber congenital amaurosis 2 10.1 CRYAA CRX
18 ptosis 10.0
19 orbital cellulitis 10.0
20 thrombocytopenia 10.0
21 optic nerve disease 10.0
22 familial retinoblastoma 10.0
23 vitreous disease 10.0
24 retinitis pigmentosa 1 10.0 CRYAA CRX
25 medulloblastoma 9.9
26 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
27 3-methylglutaconic aciduria, type iii 9.9
28 osteogenic sarcoma 9.9
29 leukemia, acute myeloid 9.9
30 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
31 low grade glioma 9.9
32 optic papillitis 9.9
33 suppression amblyopia 9.9
34 amblyopia 9.9
35 alternating exotropia 9.9
36 exotropia 9.9
37 blind hypotensive eye 9.9
38 pancytopenia 9.9
39 retinal ischemia 9.9
40 uveitis 9.9
41 pineoblastoma 9.9
42 malignant conjunctival melanoma 9.9
43 hemangioma 9.9
44 rhabdomyosarcoma 9.9
45 perivascular tumor 9.9
46 cranial nerve palsy 9.9
47 intracranial primitive neuroectodermal tumor 9.9
48 eye disease 9.9
49 neuroblastoma 9.9
50 pathologic nystagmus 9.9

Graphical network of the top 20 diseases related to Intraocular Retinoblastoma:



Diseases related to Intraocular Retinoblastoma

Symptoms & Phenotypes for Intraocular Retinoblastoma

Drugs & Therapeutics for Intraocular Retinoblastoma

Drugs for Intraocular Retinoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 3 7553-56-2 807
2
Mesna Approved, Investigational Phase 3 3375-50-6 598
3
Topotecan Approved, Investigational Phase 3 119413-54-6, 123948-87-8 60700
4
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
5
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
6
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
7
Etoposide Approved Phase 3 33419-42-0 36462
8
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
9
Lenograstim Approved, Investigational Phase 3 135968-09-1
10
Cadexomer iodine Experimental Phase 3 94820-09-4
11 Anti-Infective Agents Phase 3
12 Trace Elements Phase 3
13 Anti-Infective Agents, Local Phase 3
14 Nutrients Phase 3
15 Micronutrients Phase 3
16 Immunosuppressive Agents Phase 3
17 Alkylating Agents Phase 3
18 Immunologic Factors Phase 3
19 topoisomerase I inhibitors Phase 3
20
Liposomal doxorubicin Phase 3 31703
21 Antirheumatic Agents Phase 3
22 Antibiotics, Antitubercular Phase 3
23 Anti-Bacterial Agents Phase 3
24 Anesthetics Phase 3
25 Etoposide phosphate Phase 3
26 Tubulin Modulators Phase 3
27 Antimitotic Agents Phase 3
28
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
29
Arsenic trioxide Approved, Investigational Phase 2 1327-53-3 518740
30
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
31
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
32
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
33
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
34
Acetaminophen Approved Phase 2 103-90-2 1983
35
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
36
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
37
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
38
Promethazine Approved, Investigational Phase 2 60-87-7 4927
39
Melphalan Approved Phase 2 148-82-3 4053 460612
40
Molgramostim Investigational Phase 2 99283-10-0
41 Liver Extracts Phase 2
42 Adjuvants, Immunologic Phase 2
43 Cyclosporins Phase 2
44 Calcineurin Inhibitors Phase 2
45 Antifungal Agents Phase 2
46 Dermatologic Agents Phase 2
47 Immunoglobulins Phase 2
48 Antibodies Phase 2
49 Antibodies, Monoclonal Phase 2
50
Neomycin Approved, Vet_approved Phase 1 1404-04-2 8378

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy Completed NCT00335738 Phase 3 liposomal vincristine sulfate;carboplatin;etoposide
2 Trial of Systemic Neoadjuvant Chemotherapy for Group B Intraocular Retinoblastoma Completed NCT00079417 Phase 3 carboplatin;vincristine sulfate
3 Protocol for the Study and Treatment of Patients With Intraocular Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine and Topotecan;Vincristine + Carboplatin + Etoposide;vincristine, cyclophosphamide, and doxorubicin;Vincristine, Carboplatin and Etoposide
4 A Single Arm Trial of Systemic And Subtenon Chemotherapy For Groups C And D Intraocular Retinoblastoma Terminated NCT00072384 Phase 3 liposomal vincristine sulfate;carboplatin;etoposide
5 Phase II Study of Arsenic Trioxide in Neuroblastoma and Other Pediatric Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
6 Treatment for Extrachoroidal or Metastatic Retinoblastoma Completed NCT00004006 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;topotecan hydrochloride
7 High-Dose Thiotepa With Autologous Stem Cell Rescue in Patients With Malignancies Refractory to Conventional Chemotherapy Completed NCT00003173 Phase 2 thiotepa
8 Evaluation of Chemotherapy as Initial Treatment for Retinoblastoma Completed NCT00002794 Phase 2 carboplatin;vincristine sulfate
9 A TRIAL OF ADJUVANT CHEMOTHERAPY IN PATIENTS WITH INTRAOCULAR RETINOBLASTOMA Completed NCT00002675 Phase 2 carboplatin;cisplatin;cyclophosphamide;etoposide;mesna;vincristine sulfate
10 A Phase II Trial of Rebeccamycin Analogue (NSC #655649) in Children With Solid Tumors Completed NCT00006102 Phase 2 becatecarin
11 Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma Recruiting NCT01783535 Phase 2 vincristine;topotecan;filgrastim;PEG-filgrastim;carboplatin;etoposide;cyclophosphamide;MESNA;doxorubicin
12 Multicenter Phase II Study for International Intraocular Retinoblastoma Classification Groups B, C & D Tumors Treated With Carboplatin-Etoposide-Vincristine-Cyclosporine-Focal Therapy Multimodality Protocol (OCRN Multicenter RB 2003) Active, not recruiting NCT00110110 Phase 2 Carboplatin;Cyclosporine;Etoposide;vincristine sulfate
13 Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms Active, not recruiting NCT00445965 Phase 2
14 Intra-arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma Terminated NCT01293539 Phase 2 Melphalan hydrochloride
15 Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma Withdrawn NCT01151748 Phase 2
16 Phase I Study of Intrathecal 131-I-3F8 Monoclonal Antibody in Patients With GD2 Positive Leptomeningeal Neoplasms Completed NCT00003022 Phase 1
17 Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma Completed NCT02792036 Phase 1 Carboplatin;Maxitrol®
18 Dose Escalation of Total Marrow Irradiation Added to an Alkylator-Intense Conditioning Regimen for Patients With High Risk or Relapsed Solid Tumors Terminated NCT00623077 Phase 1 busulfan;etoposide;ifosfamide;melphalan;thiotepa;Mesna
19 Randomized Control Trial Comparing Carboplatin 560mg/m2 With 750mg/m2 for Ocular Salvage in Groups C and D Intraocular Retinoblastoma Unknown status NCT00889018 carboplatin;carboplatin
20 A Data Collection Study to Compare the Outcome for Children With Advanced Unilateral Retinoblastoma Treated With or Without Post-Enucleation Chemotherapy ± Radiotherapy on RB 2005 11 With Historical Controls Receiving no Additional Therapy Unknown status NCT00360750 carboplatin;cytarabine;etoposide;vincristine sulfate
21 Determination of Hearing Status in Children Receiving Intra-Arterial Carboplatin for Intraocular Retinoblastoma Recruiting NCT03866460

Search NIH Clinical Center for Intraocular Retinoblastoma

Genetic Tests for Intraocular Retinoblastoma

Anatomical Context for Intraocular Retinoblastoma

The Foundational Model of Anatomy Ontology organs/tissues related to Intraocular Retinoblastoma:

19
Eye

MalaCards organs/tissues related to Intraocular Retinoblastoma:

40
Eye, Pineal, Retina, T Cells, Bone, Liver, Myeloid

Publications for Intraocular Retinoblastoma

Articles related to Intraocular Retinoblastoma:

(show top 50) (show all 300)
# Title Authors PMID Year
1
Response criteria for intraocular retinoblastoma: RB-RECIST. 61
33624399 2021
2
A decision process for drug discovery in retinoblastoma. 61
33200242 2021
3
Adjuvant therapy of histopathological risk factors of retinoblastoma in Europe: A survey by the European Retinoblastoma Group (EURbG). 61
33720495 2021
4
Intravitreal melphalan hydrochloride vs propylene glycol-free melphalan for retinoblastoma vitreous seeds: Efficacy, toxicity and stability in rabbits models and patients. 61
33444583 2021
5
The Predictive Value of the Eighth Edition of the Clinical TNM Staging System for the Likelihood of Eye Salvage for Intraocular Retinoblastoma by Systemic Chemotherapy and Focal Therapy. 61
33769386 2021
6
Recurrent Somatic Chromosomal Abnormalities in Relapsed Extraocular Retinoblastoma. 61
33567541 2021
7
Development of New Solitary Retinoblastoma Tumors during and after Chemotherapy. 61
33596616 2021
8
Risk factors for recurrent retinoblastoma after intravenous chemotherapy. 61
33611762 2021
9
Management and Outcomes of Unilateral Group D Tumors in Retinoblastoma. 61
33447011 2021
10
Prospective phase II study of children affected by bilateral intraocular retinoblastoma with macular involvement of both eyes or in the only preserved eye. Macular tumor control, eye preservation rate, and visual outcome. 61
33098751 2021
11
Incidence and predictors of ophthalmic artery occlusion in intra-arterial chemotherapy for retinoblastoma. 61
33122349 2020
12
A 20-year audit of retinoblastoma treatment outcomes. 61
32376976 2020
13
Variability in retinoblastoma genome stability is driven by age and not heritability. 61
32390242 2020
14
Clinical Outcomes and Prognostic Factors of Thai Retinoblastoma Patients. 61
33022851 2020
15
Different Types of Clinical Presentations and Stages of Retinoblastoma Among Children. 61
33133838 2020
16
Chemotherapy for Retinoblastoma: Impact of Intravitreal Chemotherapy. 61
32925294 2020
17
Prognostic Factors for Eye Globe Salvage by External Beam Radiation Therapy for Resistant Intraocular Retinoblastoma. 61
33542599 2020
18
A single-arm study of systemic and sub-Tenon chemotherapy for Groups C and D intraocular retinoblastoma: A Children's Oncology Group study (ARET 0231). 61
32589362 2020
19
Association Between Genotype and Phenotype in Consecutive Unrelated Individuals With Retinoblastoma. 61
32556071 2020
20
Prognostic Information for Known Genetic Carriers of RB1 Pathogenic Variants (Germline and Mosaic). 61
32835838 2020
21
Development of In Vivo Model of Intraocular Retinoblastoma. 61
32749564 2020
22
Delayed metastasis in patients with intraocular retinoblastoma: A review of three cases. 61
32703017 2020
23
Unusual presentation of Retinoblastoma. 61
32613860 2020
24
Intra-Arterial Chemotherapy for Retinoblastoma in Infants ≤10 kg: 74 Treated Eyes with 222 IAC Sessions. 61
32586963 2020
25
Impact of Systemic Chemotherapy and Delayed Enucleation on Survival of Children with Advanced Intraocular Retinoblastoma. 61
32387053 2020
26
Clinical Features and Long-term Prognosis of Retinoblastoma according to Age at Diagnosis. 61
32495533 2020
27
Cataract surgery in treated retinoblastoma eyes: A study of 29 eyes. 61
32586135 2020
28
Screening for Pineal Trilateral Retinoblastoma Revisited: A Meta-analysis. 61
32061409 2020
29
Global Retinoblastoma Presentation and Analysis by National Income Level. 61
32105305 2020
30
Number, frequency and time interval of examinations under anesthesia in bilateral retinoblastoma. 61
31900643 2020
31
Severe Periocular Edema after Intraarterial Carboplatin Chemotherapy for Retinoblastoma in a Rabbit (Oryctolagus cuniculus) Model. 61
32160941 2020
32
Evaluating primary intra-arterial chemotherapy versus intravenous plus intra-arterial chemotherapy for advanced intraocular retinoblastoma. 61
32123960 2020
33
Tumour size criteria for Group D and E eyes in the International Classification System for Retinoblastoma: effects on rates of globe salvage and high-risk histopathologic features. 61
31421017 2020
34
The role of external beam radiation therapy for retinoblastoma after failure of combined chemoreduction and focal consolidation therapy. 61
32072842 2020
35
Combined intra-arterial chemotherapy and intravitreal melphalan for the treatment of advanced unilateral retinoblastoma. 61
32090035 2020
36
Clinical Features of Children with Retinoblastoma and Neuroblastoma. 61
32695501 2020
37
Examinations under anaesthesia as a measure of disease burden in unilateral retinoblastoma: the London experience. 61
30862620 2020
38
Clinical Presentations and Outcomes of Retinoblastoma Patients in relation to the Advent of New Multimodal Treatments: A 12-Year Report from Single Tertiary Referral Institute in Thailand. 61
33005446 2020
39
Comparison of efficacy and toxicity of intravitreal melphalan formulations for retinoblastoma. 61
32609726 2020
40
Technical and anatomical factors affecting intra-arterial chemotherapy fluoroscopy time and radiation dose for intraocular retinoblastoma. 61
31197028 2019
41
Delayed Enucleation With Neoadjuvant Chemotherapy in Advanced Intraocular Unilateral Retinoblastoma: AHOPCA II, a Prospective, Multi-Institutional Protocol in Central America. 61
31536438 2019
42
CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing. 61
31500597 2019
43
Neonatal retinoblastoma: A study of five cases. 61
31902989 2019
44
Bilateral advanced (group D or E) intraocular retinoblastoma: outcomes in 72 Asian Indian patients. 61
30932036 2019
45
Intra-arterial chemotherapy as primary or secondary treatment for infants diagnosed with advanced retinoblastoma before 3 months of age. 61
31307410 2019
46
ROUTINE FUNDUS SCREENING OF FAMILIES OF CHILDREN WITH RETINOBLASTOMA: A Prospective Study of 131 Consecutive Families. 61
29470311 2019
47
Intra-arterial chemotherapy in retinoblastoma - A paradigm change. 61
31124482 2019
48
Intra-Arterial Chemotherapy for Retinoblastoma: 8-Year Experience from a Tertiary Referral Institute in Thailand. 61
30714357 2019
49
Concomitant Intraocular Retinoblastoma and Choroidal Hemangioma in a 1-Year-Old Boy. 61
28984344 2019
50
Association of electroretinography with visual outcomes after ophthalmic artery chemosurgery for retinoblastoma in ICRb D and E eyes. 61
30650131 2019

Variations for Intraocular Retinoblastoma

Expression for Intraocular Retinoblastoma

Search GEO for disease gene expression data for Intraocular Retinoblastoma.

Pathways for Intraocular Retinoblastoma

GO Terms for Intraocular Retinoblastoma

Sources for Intraocular Retinoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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