MCID: INT082
MIFTS: 38

Intraocular Retinoblastoma

Categories: Cancer diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Intraocular Retinoblastoma

MalaCards integrated aliases for Intraocular Retinoblastoma:

Name: Intraocular Retinoblastoma 12 15 74
Pediatric Intraocular Retinoblastoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4653
NCIt 51 C7846

Summaries for Intraocular Retinoblastoma

Disease Ontology : 12 A retinoblastoma that is located in the eye and has not spread to other parts of the body.

MalaCards based summary : Intraocular Retinoblastoma, also known as pediatric intraocular retinoblastoma, is related to pediatric intraocular retinoblastoma and retinoblastoma. An important gene associated with Intraocular Retinoblastoma is CRX (Cone-Rod Homeobox). The drugs Vincristine and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and pineal, and related phenotypes are craniofacial and nervous system

Related Diseases for Intraocular Retinoblastoma

Diseases related to Intraocular Retinoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 pediatric intraocular retinoblastoma 12.6
2 retinoblastoma 10.9
3 unilateral retinoblastoma 10.4 GREM2 RBL1
4 small cell osteogenic sarcoma 10.4 ENO2 SATB2
5 accommodative esotropia 10.3 GREM2 KANTR
6 carotid body cancer 10.3 ENO2 SYP
7 malignant sertoli cell tumor 10.3 ENO2 SYP
8 urinary bladder small cell neuroendocrine carcinoma 10.3 ENO2 SYP
9 auditory agnosia 10.3 GREM2 KANTR
10 auditory system cancer 10.3 ENO2 SYP
11 sinonasal undifferentiated carcinoma 10.3 ENO2 SYP
12 pancreatic somatostatinoma 10.3 ENO2 SYP
13 cutaneous ganglioneuroma 10.3 ENO2 SYP
14 extrahepatic bile duct adenocarcinoma 10.3 ENO2 SYP
15 small cell carcinoma of the bladder 10.3 ENO2 SYP
16 papillary tumor of the pineal region 10.3 ENO2 SYP
17 sensory organ benign neoplasm 10.3 ENO2 SYP
18 orbital cancer 10.3 ENO2 SYP
19 middle ear adenoma 10.3 ENO2 SYP
20 kidney clear cell sarcoma 10.3 ENO2 SATB2
21 pulmonary large cell neuroendocrine carcinoma 10.3 ENO2 SYP
22 gallbladder small cell carcinoma 10.3 ENO2 SYP
23 clear cell ependymoma 10.3 ENO2 SYP
24 cauda equina neoplasm 10.3 ENO2 SYP
25 endometrial small cell carcinoma 10.3 ENO2 SYP
26 extraosseous chondrosarcoma 10.3 ENO2 SYP
27 subependymal glioma 10.3 ENO2 SYP
28 astroblastoma 10.3 ENO2 SYP
29 olfactory nerve neoplasm 10.3 ENO2 SYP
30 pineal gland cancer 10.3 ENO2 SYP
31 cellular ependymoma 10.3 SYP TP53
32 autonomic nervous system benign neoplasm 10.3 ENO2 SYP
33 melanotic neuroectodermal tumor 10.3 ENO2 SYP
34 benign ependymoma 10.3 ENO2 SYP
35 nodular ganglioneuroblastoma 10.3 ENO2 SYP
36 pineocytoma 10.3 ENO2 SYP
37 olfactory groove meningioma 10.2 SYP TP53
38 periosteal osteogenic sarcoma 10.2 SATB2 TP53
39 angiomyoma 10.2 ENO2 SYP
40 cervical clear cell adenocarcinoma 10.2 ENO2 SYP
41 supraglottis cancer 10.2 ENO2 TP53
42 gastric small cell carcinoma 10.2 ENO2 SYP
43 desmoplastic small round cell tumor 10.2 ENO2 SYP
44 subependymoma 10.2 ENO2 SYP
45 glomangiosarcoma 10.2 KANTR TP53
46 carcinoid tumors, intestinal 10.2 ENO2 SYP
47 respiratory system benign neoplasm 10.2 ENO2 SYP
48 glycogen-rich clear cell breast carcinoma 10.2 SYP TP53
49 bone benign neoplasm 10.2 ENO2 SYP
50 postencephalitic parkinson disease 10.2 KANTR SYP

Graphical network of the top 20 diseases related to Intraocular Retinoblastoma:



Diseases related to Intraocular Retinoblastoma

Symptoms & Phenotypes for Intraocular Retinoblastoma

MGI Mouse Phenotypes related to Intraocular Retinoblastoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.63 ENO2 GREM2 MDM4 RBL1 SATB2 TP53
2 nervous system MP:0003631 9.56 CRX ENO2 MDM4 PVALB RBL1 SYK
3 respiratory system MP:0005388 9.1 BPIFA1 ENO2 RBL1 SATB2 SYK TP53

Drugs & Therapeutics for Intraocular Retinoblastoma

Drugs for Intraocular Retinoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
2
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 38904 498142
3
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
4
Iodine Approved, Investigational Phase 3,Phase 2,Phase 1 7553-56-2 807
5
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
6
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
7
Topotecan Approved, Investigational Phase 3,Phase 2,Not Applicable 119413-54-6, 123948-87-8 60700
8
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
9
Mesna Approved, Investigational Phase 3,Phase 2,Phase 1 3375-50-6 598
10
Doxil Approved June 1999 Phase 3,Phase 2 31703
11 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
12 Antimitotic Agents Phase 3,Phase 2,Phase 1,Not Applicable
13 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
14 Etoposide phosphate Phase 3,Phase 2,Phase 1,Not Applicable
15 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
16 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
17 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable
18 Nutrients Phase 3,Phase 2
19 Micronutrients Phase 3,Phase 2
20 Anti-Infective Agents, Local Phase 3,Phase 2
21 Trace Elements Phase 3,Phase 2
22 cadexomer iodine Phase 3,Phase 2,Phase 1
23 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
24 Alkylating Agents Phase 3,Phase 2,Phase 1
25 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
26 Antirheumatic Agents Phase 3,Phase 2
27 Antibiotics, Antitubercular Phase 3,Phase 2
28 topoisomerase I inhibitors Phase 3,Phase 2,Not Applicable
29 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1
30 Anesthetics Phase 3
31
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
32
Thiotepa Approved, Investigational Phase 2,Phase 1 52-24-4 5453
33
Arsenic trioxide Approved, Investigational Phase 2 1327-53-3 518740
34
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2,Phase 1 1177-87-3
35
Dexamethasone Approved, Investigational, Vet_approved Phase 2,Phase 1 50-02-2 5743
36
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
37
Sargramostim Approved, Investigational Phase 2,Phase 1 123774-72-1, 83869-56-1
38
Promethazine Approved, Investigational Phase 2 60-87-7 4927
39
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
40
Acetaminophen Approved Phase 2 103-90-2 1983
41
Melphalan Approved Phase 2,Phase 1 148-82-3 460612 4053
42
Emodepside Investigational, Vet_approved Phase 2 155030-63-0
43 Liver Extracts Phase 2,Phase 1
44 Antibodies Phase 2,Phase 1
45 Antineoplastic Agents, Immunological Phase 2,Phase 1
46 Antibodies, Monoclonal Phase 2,Phase 1
47 Immunoglobulins Phase 2,Phase 1
48 Protective Agents Phase 2,Phase 1
49 BB 1101 Phase 2,Phase 1
50 Cyclosporins Phase 2

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Neoadjuvant Carboplatin and Vincristine and Standard Local Ophthalmic Therapy in Treating Patients With Intraocular Retinoblastoma Completed NCT00079417 Phase 3 carboplatin;vincristine sulfate
2 Vincristine, Carboplatin, and Etoposide or Observation Only in Treating Patients Who Have Undergone Surgery for Newly Diagnosed Retinoblastoma Completed NCT00335738 Phase 3 liposomal vincristine sulfate;carboplatin;etoposide
3 Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine and Topotecan;Vincristine + Carboplatin + Etoposide;vincristine, cyclophosphamide, and doxorubicin;Vincristine, Carboplatin and Etoposide
4 Systemic Chemotherapy and Subtenon Carboplatin, and Local Ophthalmic Therapy in Children With Intraocular Retinoblastoma Terminated NCT00072384 Phase 3 liposomal vincristine sulfate;carboplatin;etoposide
5 Chemotherapy in Treating Patients With Retinoblastoma Completed NCT00002675 Phase 2 carboplatin;cisplatin;cyclophosphamide;etoposide;mesna;vincristine sulfate
6 Carboplatin Plus Vincristine in Treating Children With Retinoblastoma Completed NCT00002794 Phase 2 carboplatin;vincristine sulfate
7 Combination Chemotherapy, Radiation Therapy, and Bone Marrow Transplantation in Treating Patients With Retinoblastoma Completed NCT00004006 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;topotecan hydrochloride
8 High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors Completed NCT00003173 Phase 2 thiotepa
9 Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
10 Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00006102 Phase 2 becatecarin
11 Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma Recruiting NCT01783535 Phase 2 vincristine;topotecan;filgrastim;PEG-filgrastim;carboplatin;etoposide;cyclophosphamide;MESNA;doxorubicin
12 Combination Chemotherapy and Cyclosporine Followed by Focal Therapy for Bilateral Retinoblastoma Active, not recruiting NCT00110110 Phase 2 Carboplatin;Cyclosporine;Etoposide;vincristine sulfate
13 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
14 Intra-arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma Terminated NCT01293539 Phase 2 Melphalan hydrochloride
15 Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma Withdrawn NCT01151748 Phase 2
16 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1
17 Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma Recruiting NCT02792036 Phase 1 Carboplatin;Maxitrol®
18 Alternating Systemic Chemotherapy and Intra-Arterial Melphalan Chemotherapy in Children With Intra-Ocular Retinoblastoma Active, not recruiting NCT02116959 Phase 1 Melphalan;Carboplatin;Etoposide;Vincristine
19 MT2004-30: Tomotherapy for Solid Tumors Terminated NCT00623077 Phase 1 busulfan;etoposide;ifosfamide;melphalan;thiotepa;Mesna
20 Trial Comparing Two Carboplatin Doses in Groups C and D Intraocular Retinoblastoma Unknown status NCT00889018 Not Applicable carboplatin;carboplatin
21 Chemotherapy With or Without Radiation Therapy or Observation in Treating Young Patients With Advanced Retinoblastoma Who Have Undergone Surgery to Remove the Eye Unknown status NCT00360750 Not Applicable carboplatin;cytarabine;etoposide;vincristine sulfate
22 Genetic Mutations and Environmental Exposure in Young Patients With Retinoblastoma and in Their Parents and Young Healthy Unrelated Volunteers Completed NCT00690469
23 Collecting and Storing Tissue From Young Patients With Cancer Completed NCT00898755
24 Determining Whether Intra-Arterial Carboplatin Causes Hearing Loss in Children Recruiting NCT03866460
25 Studying Health Outcomes After Treatment in Patients With Retinoblastoma Recruiting NCT03932786
26 RCT of Ballon Technique VS Selective Ophthalmic Artery Infusion For the Retinoblastoma Patients Not yet recruiting NCT03439397 Not Applicable
27 Pilot Study of Topotecan/Vincristine With Subconjunctival Carboplatin for Patients With Bilateral Retinoblastoma Withdrawn NCT00980551 Not Applicable subtenon Carboplatin;Topotecan Hydrochloride;Vincristine;Filgrastim

Search NIH Clinical Center for Intraocular Retinoblastoma

Genetic Tests for Intraocular Retinoblastoma

Anatomical Context for Intraocular Retinoblastoma

MalaCards organs/tissues related to Intraocular Retinoblastoma:

42
Eye, Bone, Pineal, Liver, Bone Marrow, Brain, Cerebellum

The Foundational Model of Anatomy Ontology organs/tissues related to Intraocular Retinoblastoma:

20
The Eye

Publications for Intraocular Retinoblastoma

Articles related to Intraocular Retinoblastoma:

(show top 50) (show all 109)
# Title Authors Year
1
Bilateral advanced (group D or E) intraocular retinoblastoma: outcomes in 72 Asian Indian patients. ( 30932036 )
2019
2
Necrotic intraocular retinoblastoma associated with orbital cellulitis. ( 28254446 )
2018
3
HIGH-RISK INTRAOCULAR RETINOBLASTOMA: Comparison Between Asian Indians and Americans From Two Major Referral Centers. ( 28834944 )
2018
4
Three presentations of CNS disease in patients with intraocular retinoblastoma at a tertiary medical center in the United States. ( 28949779 )
2018
5
Pars Plana Vitrectomy and Endoresection of Refractory Intraocular Retinoblastoma. ( 29153457 )
2018
6
Is a diagnostic lumbar puncture indicated in intraocular retinoblastoma? ( 29676357 )
2018
7
Managing and treating intraocular retinoblastoma. ( 29915462 )
2018
8
Re: Zhao et al.: Pars plana vitrectomy and endoresection of refractory intraocular retinoblastoma (Ophthalmology. 2018;125:320-322). ( 29935678 )
2018
9
Intra-arterial chemotherapy for unilateral advanced intraocular retinoblastoma: Results and short-term complications. ( 30334950 )
2018
10
Concomitant Intraocular Retinoblastoma and Choroidal Hemangioma in a 1-Year-Old Boy. ( 28984344 )
2017
11
Evolution of Chemotherapy Approaches for the Treatment of Intraocular Retinoblastoma: A Comprehensive Review. ( 27898618 )
2017
12
Systemic neoadjuvant chemotherapy for Group B intraocular retinoblastoma (ARET0331): A report from the Children's Oncology Group. ( 28019092 )
2017
13
Ocular Salvage and Vision Preservation Using a Topotecan-Based Regimen for Advanced Intraocular Retinoblastoma. ( 28034080 )
2017
14
High-Risk Histopathology Features in Primary and Secondary Enucleated International Intraocular Retinoblastoma Classification Group D Eyes. ( 28302322 )
2017
15
Unusually very late-onset new growth of intraocular retinoblastoma: A case report and review of literature. ( 29503965 )
2017
16
Transorbital anastomotic pathways between the external and internal carotid systems in children affected by intraocular retinoblastoma. ( 26198114 )
2016
17
Selective Ophthalmic Artery Infusion Chemotherapy for Advanced Intraocular Retinoblastoma: CCHMC Early Experience. ( 26583615 )
2016
18
Incidence of Orbital Recurrence After Enucleation or Ophthalmic Artery Chemosurgery for Advanced Intraocular Retinoblastoma. ( 26583950 )
2016
19
Incidence of Orbital Recurrence After Enucleation or Ophthalmic Artery Chemosurgery for Advanced Intraocular Retinoblastoma--Reply. ( 26584063 )
2016
20
Chemoreduction of Progressive Intraocular Retinoblastoma by Systemic Topotecan. ( 26760494 )
2016
21
Long-term visual outcomes in intraocular retinoblastoma with eye preservation. ( 26781471 )
2016
22
Hemodynamic and Anatomic Variations Require an Adaptable Approach during Intra-Arterial Chemotherapy for Intraocular Retinoblastoma: Alternative Routes, Strategies, and Follow-Up. ( 26915566 )
2016
23
Embryologic Anatomic Variations: Challenges in Intra-Arterial Chemotherapy for Intraocular Retinoblastoma. ( 27469215 )
2016
24
Selective ophthalmic arterial injection of melphalan for intraocular retinoblastoma: a 4-year review. ( 25465196 )
2015
25
Intravitreal injection of melphalan for intraocular retinoblastoma. ( 25808017 )
2015
26
Socioeconomic and psychological impact of treatment for unilateral intraocular retinoblastoma. ( 25982424 )
2015
27
Enucleation vs Ophthalmic Artery Chemosurgery for Advanced Intraocular Retinoblastoma: A Retrospective Analysis. ( 26181236 )
2015
28
Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma. ( 26230335 )
2015
29
Alternated intra-arterial and intravitreal chemotherapy for advanced intraocular retinoblastoma: preliminary successful results without systemic chemotherapy. ( 26416040 )
2015
30
Clinical presentation of intraocular retinoblastoma; 5-year hospital-based registry in Egypt. ( 26490323 )
2015
31
Radiation dose reduction in intra-arterial chemotherapy infusion for intraocular retinoblastoma. ( 24385553 )
2014
32
Clinical efficacy and prognostic factors of chemoreduction combined with topical treatment for advanced intraocular retinoblastoma. ( 25292067 )
2014
33
Superselective ophthalmic artery infusion of melphalan for intraocular retinoblastoma: preliminary results from 140 treatments. ( 22268993 )
2013
34
Intra-arterial chemotherapy with melphalan for intraocular retinoblastoma. ( 23853166 )
2013
35
Salvage/adjuvant brachytherapy after ophthalmic artery chemosurgery for intraocular retinoblastoma. ( 23953635 )
2013
36
Carboplatin +/- topotecan ophthalmic artery chemosurgery for intraocular retinoblastoma. ( 23991112 )
2013
37
Second malignant neoplasms following chemoreduction with carboplatin, etoposide, and vincristine in 245 patients with intraocular retinoblastoma. ( 21826785 )
2012
38
Zygomatico-orbital intra-arterial melphalan infusion for intraocular retinoblastoma. ( 21990490 )
2012
39
A histopathologic analysis of eyes primarily enucleated for advanced intraocular retinoblastoma from a developing country. ( 22288967 )
2012
40
Predictors of long-term visual outcome after chemoreduction for management of intraocular retinoblastoma. ( 22300311 )
2012
41
Intra-arterial chemotherapy as a treatment for intraocular retinoblastoma: alternatives to direct ophthalmic artery catheterization. ( 22442047 )
2012
42
Topotecan and vincristine combination is effective against advanced bilateral intraocular retinoblastoma and has manageable toxicity. ( 22516936 )
2012
43
Ophthalmic artery chemosurgery for less advanced intraocular retinoblastoma: five year review. ( 22545080 )
2012
44
Three-drug intra-arterial chemotherapy using simultaneous carboplatin, topotecan and melphalan for intraocular retinoblastoma: preliminary results. ( 22863945 )
2012
45
Severe aseptic orbital cellulitis with subtenon carboplatin for intraocular retinoblastoma. ( 21157073 )
2011
46
Occurrence of sectoral choroidal occlusive vasculopathy and retinal arteriolar embolization after superselective ophthalmic artery chemotherapy for advanced intraocular retinoblastoma. ( 21273941 )
2011
47
Selective ophthalmic artery infusion of chemotherapy for advanced intraocular retinoblastoma: initial experience with 17 tumors. ( 21294621 )
2011
48
Periocular topotecan for intraocular retinoblastoma. ( 21670340 )
2011
49
Clinical characteristics and treatment outcome of children with intraocular retinoblastoma: a report from a Chinese cooperative group. ( 21681922 )
2011
50
Selective ophthalmic arterial injection therapy for intraocular retinoblastoma: the long-term prognosis. ( 21715012 )
2011

Variations for Intraocular Retinoblastoma

Expression for Intraocular Retinoblastoma

Search GEO for disease gene expression data for Intraocular Retinoblastoma.

Pathways for Intraocular Retinoblastoma

GO Terms for Intraocular Retinoblastoma

Biological processes related to Intraocular Retinoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.35 MDM4 MLX RBL1 SATB2 TP53
2 DNA damage response, signal transduction by p53 class mediator GO:0030330 8.62 MDM4 TP53

Sources for Intraocular Retinoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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