MCID: INT041
MIFTS: 26

Intratubular Embryonal Carcinoma

Categories: Cancer diseases, Endocrine diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Intratubular Embryonal Carcinoma

MalaCards integrated aliases for Intratubular Embryonal Carcinoma:

Name: Intratubular Embryonal Carcinoma 12 15
Stage 0 Testicular Embryonal Carcinoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:8275
NCIt 50 C7325
UMLS 70 C1336096

Summaries for Intratubular Embryonal Carcinoma

Disease Ontology : 12 An embryonal testis carcinoma that is located within a tubule.

MalaCards based summary : Intratubular Embryonal Carcinoma, also known as stage 0 testicular embryonal carcinoma, is related to mixed germ cell tumor and embryonal carcinoma. An important gene associated with Intratubular Embryonal Carcinoma is TNFRSF8 (TNF Receptor Superfamily Member 8), and among its related pathways/superpathways are Developmental Biology and Endometrial cancer. Affiliated tissues include testis, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Intratubular Embryonal Carcinoma

Diseases related to Intratubular Embryonal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 318)
# Related Disease Score Top Affiliating Genes
1 mixed germ cell tumor 30.3 KIT AFP
2 embryonal carcinoma 30.0 TNFRSF8 POU5F1 KIT AFP
3 seminoma 29.2 TP53 TNFRSF8 POU5F1 KIT AFP
4 pleural lipoma 10.3 TNFRSF8 KIT
5 cutaneous ganglioneuroma 10.2 KRT20 KIT
6 orbital cellulitis 10.2 TNFRSF8 KRT7
7 urethral villous adenoma 10.2 KRT7 KRT20
8 bladder benign neoplasm 10.2 KRT7 KRT20
9 nephrogenic adenoma of urinary bladder 10.2 KRT7 KRT20
10 atrophic vulva 10.2 KRT7 KRT20
11 pancreatic serous cystadenocarcinoma 10.2 KRT7 KRT20
12 urinary bladder villous adenoma 10.2 KRT7 KRT20
13 vulva adenocarcinoma 10.2 KRT7 KRT20
14 vaginal tubulovillous adenoma 10.2 KRT7 KRT20
15 female urethral cancer 10.2 KRT7 KRT20
16 cystitis cystica 10.2 KRT7 KRT20
17 mucinous ovarian cystadenoma 10.2 KRT7 KRT20
18 rectosigmoid junction neoplasm 10.2 KRT7 KRT20
19 transverse colon cancer 10.2 KRT7 KRT20
20 sigmoid neoplasm 10.2 KRT7 KRT20
21 krukenberg carcinoma 10.2 KRT7 KRT20
22 urinary bladder small cell neuroendocrine carcinoma 10.2 KRT7 KRT20
23 vulvar apocrine adenocarcinoma 10.2 KRT7 KRT20
24 eyelid carcinoma 10.2 KRT7 KRT20
25 jejunal cancer 10.2 KRT7 KRT20
26 germ cells tumors 10.2
27 nonseminomatous germ cell tumor 10.2
28 malignant syringoma 10.2 KRT7 KRT20
29 ovarian large-cell neuroendocrine carcinoma 10.2 KRT7 KRT20
30 anal canal adenocarcinoma 10.2 KRT7 KRT20
31 appendix adenocarcinoma 10.2 KRT7 KRT20
32 supine hypotensive syndrome 10.2 KRT7 KRT20
33 mucinous bronchioloalveolar adenocarcinoma 10.2 KRT7 KRT20
34 jejunal adenocarcinoma 10.2 KRT7 KRT20
35 meibomian cyst 10.2 KRT7 KRT20
36 gastric diffuse adenocarcinoma 10.2 KRT7 KRT20
37 nephrogenic adenoma of the urethra 10.2 KRT7 KRT20
38 pancreatic mucinous cystadenoma 10.2 KRT7 KRT20
39 linitis plastica 10.2 KRT7 KRT20
40 squamous papillomatosis 10.2 KRT7 KRT20
41 ovarian mucinous neoplasm 10.2 KRT7 KRT20
42 cervical adenoid cystic carcinoma 10.2 KRT7 KIT
43 vaginal adenoma 10.2 KRT7 KRT20
44 ovarian brenner tumor 10.2 KRT7 KRT20
45 vaginal benign neoplasm 10.2 KRT7 KRT20
46 ceruminous adenocarcinoma 10.2 KRT7 KIT
47 prostate neuroendocrine neoplasm 10.2 KRT7 KRT20
48 bladder lateral wall cancer 10.2 KRT7 KRT20
49 breast leiomyosarcoma 10.2 KRT7 KIT
50 breast osteosarcoma 10.2 KRT7 KRT20

Graphical network of the top 20 diseases related to Intratubular Embryonal Carcinoma:



Diseases related to Intratubular Embryonal Carcinoma

Symptoms & Phenotypes for Intratubular Embryonal Carcinoma

GenomeRNAi Phenotypes related to Intratubular Embryonal Carcinoma according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.4 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.4 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-137 9.4 PLAU
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-138 9.4 PLAU
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.4 PLAU
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.4 AFP
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-32 9.4 PLAU
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.4 AFP
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.4 AFP
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.4 KRT7
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.4 AFP
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-92 9.4 PLAU

MGI Mouse Phenotypes related to Intratubular Embryonal Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.5 AFP KIT PLAU POU5F1 TCF4 TNFRSF8
2 neoplasm MP:0002006 9.02 AFP KIT MMP9 PLAU TP53

Drugs & Therapeutics for Intratubular Embryonal Carcinoma

Search Clinical Trials , NIH Clinical Center for Intratubular Embryonal Carcinoma

Genetic Tests for Intratubular Embryonal Carcinoma

Anatomical Context for Intratubular Embryonal Carcinoma

MalaCards organs/tissues related to Intratubular Embryonal Carcinoma:

40
Testis

Publications for Intratubular Embryonal Carcinoma

Articles related to Intratubular Embryonal Carcinoma:

# Title Authors PMID Year
1
Intratubular Teratoma: A Rare Form of Testicular Germ Cell Neoplasia. 61
30907201 2019
2
Frequency and Markers of Precursor Lesions and Implications for the Pathogenesis of Testicular Germ Cell Tumors. 61
29037766 2017
3
Association of intratubular seminoma and intratubular embryonal carcinoma with invasive testicular germ cell tumors. 61
17592271 2007
4
Microinvasive germ cell tumor of the testis. 61
15968545 2005
5
The frequency of intratubular embryonal carcinoma: implications for the pathogenesis of germ cell tumours. 61
15279634 2004
6
Intratubular embryonal carcinoma. 61
11900581 2002
7
[Intratubular neoplasm adjacent to germ cell tumor of the testis]. 61
2490348 1989
8
Undifferentiated intratubular germ cell tumor of the testis: light and electron microscopic study of a unique case. 61
455223 1979

Variations for Intratubular Embryonal Carcinoma

Expression for Intratubular Embryonal Carcinoma

Search GEO for disease gene expression data for Intratubular Embryonal Carcinoma.

Pathways for Intratubular Embryonal Carcinoma

Pathways related to Intratubular Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.31 TCF4 POU5F1 MMP9 KRT7 KRT20 KIT
2
Show member pathways
12.3 TP53 PLAU MMP9 KIT
3 11.86 TP53 PLAU MMP9
4 11.78 TP53 PLAU MMP9
5
Show member pathways
11.58 TP53 POU5F1 PLAU
6 11.35 TP53 TCF4 MMP9

GO Terms for Intratubular Embryonal Carcinoma

Cellular components related to Intratubular Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 TP53 TCF4 POU5F1

Biological processes related to Intratubular Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.13 TP53 PLAU KIT
2 positive regulation of release of cytochrome c from mitochondria GO:0090200 8.62 TP53 MMP9

Sources for Intratubular Embryonal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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