MCID: INT041
MIFTS: 27

Intratubular Embryonal Carcinoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Intratubular Embryonal Carcinoma

MalaCards integrated aliases for Intratubular Embryonal Carcinoma:

Name: Intratubular Embryonal Carcinoma 12 15
Stage 0 Testicular Embryonal Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8275
NCIt 50 C7325
UMLS 73 C1336096

Summaries for Intratubular Embryonal Carcinoma

Disease Ontology : 12 An embryonal testis carcinoma that is located within a tubule.

MalaCards based summary : Intratubular Embryonal Carcinoma, also known as stage 0 testicular embryonal carcinoma, is related to embryonal carcinoma and seminoma. An important gene associated with Intratubular Embryonal Carcinoma is TCF4 (Transcription Factor 4), and among its related pathways/superpathways are Developmental Biology and amb2 Integrin signaling. Affiliated tissues include testis, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Intratubular Embryonal Carcinoma

Diseases related to Intratubular Embryonal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 embryonal carcinoma 29.1 AFP KIT POU5F1 TNFRSF8
2 seminoma 28.8 AFP KIT POU5F1 TNFRSF8
3 cutaneous ganglioneuroma 10.7 KIT KRT20
4 prostatic acinar adenocarcinoma 10.7 KIT KRT20
5 cystic basal cell carcinoma 10.5 KRT20 KRT7
6 vaginal benign neoplasm 10.5 KRT20 KRT7
7 seminal vesicle adenocarcinoma 10.5 KRT20 KRT7
8 transverse colon cancer 10.5 KRT20 KRT7
9 appendix adenocarcinoma 10.5 KRT20 KRT7
10 ovarian large-cell neuroendocrine carcinoma 10.5 KRT20 KRT7
11 vaginal adenoma 10.5 KRT20 KRT7
12 vaginal tubulovillous adenoma 10.5 KRT20 KRT7
13 eyelid neoplasm 10.5 KRT20 KRT7
14 glandular cystitis 10.5 KRT20 KRT7
15 malignant syringoma 10.5 KRT20 KRT7
16 krukenberg carcinoma 10.5 KRT20 KRT7
17 large intestine adenocarcinoma 10.5 KRT20 KRT7
18 linitis plastica 10.5 KRT20 KRT7
19 lung acinar adenocarcinoma 10.5 KRT20 KRT7
20 small cell carcinoma of the bladder 10.5 KRT20 KRT7
21 adenoid squamous cell carcinoma 10.5 KRT20 KRT7
22 eccrine sweat gland neoplasm 10.5 KRT20 KRT7
23 mucinous bronchioloalveolar adenocarcinoma 10.5 KRT20 KRT7
24 vulval paget's disease 10.5 KRT20 KRT7
25 ovarian mucinous adenocarcinoma 10.5 KRT20 KRT7
26 thymus adenocarcinoma 10.5 KRT20 KRT7
27 jejunal cancer 10.5 KIT KRT7
28 gastric diffuse adenocarcinoma 10.5 KRT20 KRT7
29 meibomian cyst 10.5 KRT20 KRT7
30 bladder lymphoma 10.5 KRT20 KRT7
31 papillary serous adenocarcinoma 10.5 KRT20 KRT7
32 bladder adenocarcinoma 10.5 KRT20 KRT7
33 jejunal adenocarcinoma 10.5 KRT20 KRT7
34 chronic cystitis 10.5 KRT20 KRT7
35 vulva adenocarcinoma 10.5 KRT20 KRT7
36 cribriform carcinoma 10.5 KIT KRT7
37 malignant mixed mullerian tumor 10.5 KIT KRT7
38 medulloepithelioma 10.5 KRT20 KRT7
39 glycogen-rich clear cell breast carcinoma 10.5 KRT20 KRT7
40 adenoid basal cell carcinoma 10.5 KIT KRT7
41 rectum adenocarcinoma 10.5 KRT20 KRT7
42 renal pelvis carcinoma 10.5 KRT20 KRT7
43 paget disease, extramammary 10.5 KRT20 KRT7
44 ampulla of vater neoplasm 10.5 KRT20 KRT7
45 conventional fibrosarcoma 10.5 KIT TNFRSF8
46 appendix cancer 10.4 KRT20 KRT7
47 ampulla of vater adenocarcinoma 10.4 KRT20 KRT7
48 mucinous cystadenocarcinoma 10.4 KRT20 KRT7
49 biliary papillomatosis 10.4 KRT20 KRT7
50 lymphoepithelioma-like carcinoma 10.4 KRT20 KRT7

Graphical network of the top 20 diseases related to Intratubular Embryonal Carcinoma:



Diseases related to Intratubular Embryonal Carcinoma

Symptoms & Phenotypes for Intratubular Embryonal Carcinoma

GenomeRNAi Phenotypes related to Intratubular Embryonal Carcinoma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.68 PLAU
2 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.68 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.68 AFP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.68 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.68 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.68 KRT7
7 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.68 PLAU
8 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.68 PLAU
9 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.68 POU5F1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.68 PLAU
11 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.68 PLAU POU5F1 AFP KRT7
12 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.68 PLAU
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.68 AFP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.68 PLAU POU5F1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.68 AFP
16 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.68 POU5F1 KRT7
17 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.68 PLAU
18 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.68 PLAU

MGI Mouse Phenotypes related to Intratubular Embryonal Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.1 AFP KIT PLAU POU5F1 TCF4 TNFRSF8

Drugs & Therapeutics for Intratubular Embryonal Carcinoma

Search Clinical Trials , NIH Clinical Center for Intratubular Embryonal Carcinoma

Genetic Tests for Intratubular Embryonal Carcinoma

Anatomical Context for Intratubular Embryonal Carcinoma

MalaCards organs/tissues related to Intratubular Embryonal Carcinoma:

41
Testis

Publications for Intratubular Embryonal Carcinoma

Articles related to Intratubular Embryonal Carcinoma:

# Title Authors Year
1
Association of intratubular seminoma and intratubular embryonal carcinoma with invasive testicular germ cell tumors. ( 17592271 )
2007
2
The frequency of intratubular embryonal carcinoma: implications for the pathogenesis of germ cell tumours. ( 15279634 )
2004
3
Intratubular embryonal carcinoma. ( 11900581 )
2002

Variations for Intratubular Embryonal Carcinoma

Expression for Intratubular Embryonal Carcinoma

Search GEO for disease gene expression data for Intratubular Embryonal Carcinoma.

Pathways for Intratubular Embryonal Carcinoma

Pathways related to Intratubular Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.31 KIT KRT20 KRT7 MMP9 POU5F1 TCF4
2 11 MMP9 PLAU
3 10.93 MMP9 PLAU
4
Show member pathways
10.81 MMP9 PLAU
5 10.49 MMP9 PLAU

GO Terms for Intratubular Embryonal Carcinoma

Biological processes related to Intratubular Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.13 KIT PLAU TNFRSF8
2 positive regulation of cell migration GO:0030335 8.8 KIT MMP9 PLAU

Molecular functions related to Intratubular Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine binding GO:0019955 8.62 KIT POU5F1

Sources for Intratubular Embryonal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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