MCID: INT221
MIFTS: 38

Intravascular Large B-Cell Lymphoma

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Intravascular Large B-Cell Lymphoma

MalaCards integrated aliases for Intravascular Large B-Cell Lymphoma:

Name: Intravascular Large B-Cell Lymphoma 60
Angioendotheliomatosis Proliferans Systemisata 60
Malignant Angioendotheliomatosis 60
Angiotropic Large Cell Lymphoma 60
Intravascular Lymphomatosis 60
Tappeiner-Pfleger Disease 60
Angioendotheliomatosis 74

Characteristics:

Orphanet epidemiological data:

60
intravascular large b-cell lymphoma
Inheritance: Not applicable;

Classifications:



External Ids:

ICD10 via Orphanet 35 C83.3
Orphanet 60 ORPHA98839
UMLS 74 C0334660

Summaries for Intravascular Large B-Cell Lymphoma

MalaCards based summary : Intravascular Large B-Cell Lymphoma, also known as angioendotheliomatosis proliferans systemisata, is related to chromosomal triplication and diffuse large b-cell lymphoma. An important gene associated with Intravascular Large B-Cell Lymphoma is BCL6 (BCL6 Transcription Repressor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and NF-kappaB Signaling. Affiliated tissues include b cells, skin and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Intravascular Large B-Cell Lymphoma

Diseases related to Intravascular Large B-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 chromosomal triplication 30.3 BCL6 KMT2A
2 diffuse large b-cell lymphoma 30.3 BCL6 CD5 MME
3 lymphosarcoma 30.2 BCL6 CD5
4 primary central nervous system lymphoma 30.2 BCL2 BCL6
5 acquired immunodeficiency syndrome 30.0 B2M BCL6
6 lymphoma, hodgkin, classic 29.8 BCL6 CD5 MME
7 leukemia, chronic lymphocytic 29.5 B2M BCL2 BCL6 CD5
8 b-cell lymphomas 29.4 BCL2 BCL6 CD5 MME
9 lymphocytic leukemia 29.3 BCL2 CD5 KMT2A MME
10 lymphoma 11.3
11 hemangioma 10.3
12 panniculitis 10.3
13 stroke, ischemic 10.3
14 thrombocytopenia 10.3
15 thrombosis 10.3
16 telangiectasis 10.3
17 dementia 10.3
18 cholecystitis 10.3
19 senile angioma 10.3
20 hypopituitarism 10.3
21 breast lymphoma 10.2 BCL6 CD5
22 composite lymphoma 10.2 BCL6 CD5
23 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 10.2 BCL2 BCL6
24 nodal marginal zone b-cell lymphoma 10.2 BCL2 BCL6
25 colon lymphoma 10.2 BCL6 CD5
26 follicular lymphoma 1 10.2 BCL2 BCL6
27 rheumatoid arthritis 10.2
28 arthritis 10.2
29 glomerulonephritis 10.2
30 colitis 10.2
31 pancytopenia 10.2
32 membranoproliferative glomerulonephritis 10.2
33 interstitial lung disease 10.2
34 cellulitis 10.2
35 lung disease 10.2
36 marek disease 10.2
37 epidural neoplasm 10.2 BCL6 CD5
38 waldenstroem's macroglobulinemia 10.2 B2M CD5
39 histiocytosis 10.1
40 malignant histiocytosis 10.1
41 polymorphic reticulosis 10.1
42 lung lymphoma 10.1 BCL6 CD5
43 human herpesvirus 8 10.1 BCL2 BCL6
44 dendritic cell thymoma 10.1 BCL2 CD5
45 heart lymphoma 10.1 BCL6 MME
46 anterior scleritis 10.1 B2M CD5
47 ectopic thymus 10.1 BCL2 CD5
48 epithelial malignant thymoma 10.1 BCL2 CD5
49 gastric lymphoma 10.1 BCL2 BCL6
50 testicular lymphoma 10.1 BCL6 MME

Graphical network of the top 20 diseases related to Intravascular Large B-Cell Lymphoma:



Diseases related to Intravascular Large B-Cell Lymphoma

Symptoms & Phenotypes for Intravascular Large B-Cell Lymphoma

MGI Mouse Phenotypes related to Intravascular Large B-Cell Lymphoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 B2M BCL2 BCL6 CD5 IL2RB KMT2A
2 immune system MP:0005387 9.8 B2M BCL2 BCL6 CD5 IL2RB KMT2A
3 integument MP:0010771 9.63 B2M BCL2 CD5 IL2RB KMT2A MME
4 liver/biliary system MP:0005370 9.35 B2M BCL6 IL2RB KMT2A MME
5 reproductive system MP:0005389 9.02 B2M BCL2 BCL6 IL2RB KMT2A

Drugs & Therapeutics for Intravascular Large B-Cell Lymphoma

Search Clinical Trials , NIH Clinical Center for Intravascular Large B-Cell Lymphoma

Genetic Tests for Intravascular Large B-Cell Lymphoma

Anatomical Context for Intravascular Large B-Cell Lymphoma

MalaCards organs/tissues related to Intravascular Large B-Cell Lymphoma:

42
B Cells, Skin, Bone, T Cells, Prostate, Bone Marrow, Liver

Publications for Intravascular Large B-Cell Lymphoma

Articles related to Intravascular Large B-Cell Lymphoma:

(show top 50) (show all 327)
# Title Authors Year
1
Outcome of patients receiving consolidative autologous peripheral blood stem cell transplantation in the frontline treatment of intravascular large B-cell lymphoma: Adult Lymphoma Working Group of the Japan Society for Hematopoietic Cell Transplantation. ( 30809035 )
2019
2
Intravascular large B-cell lymphoma with initial presentation in skin: a rare mimicker of cellulitis. ( 30998920 )
2019
3
Intravascular large B-cell lymphoma with a high titer of proteinase-3-anti-neutrophil cytoplasmic antibody mimicking granulomatosis with polyangiitis. ( 27398728 )
2019
4
Random Skin Biopsies Before Brain Biopsy for Intravascular Large B-Cell Lymphoma. ( 30261371 )
2019
5
Intravascular large B-cell lymphoma presenting with diffusely increased pulmonary fluorodeoxyglucose uptake without corresponding CT abnormality. ( 30510608 )
2019
6
Incisional random skin biopsy, not punch biopsy, is an appropriate method for diagnosis of intravascular large B-cell lymphoma: A clinicopathological study of 25 patients. ( 30609011 )
2019
7
Sensitivity and specificity of incisional random skin biopsy for diagnosis of intravascular large B-cell lymphoma. ( 30647028 )
2019
8
Intravascular large B-cell lymphoma involving large blood vessels, three autopsy cases. ( 30672647 )
2019
9
Divergence and heterogeneity of neoplastic PD-L1 expression: Two autopsy case reports of intravascular large B-cell lymphoma. ( 30688388 )
2019
10
Intravascular large B-cell lymphoma presenting with hearing loss and dizziness: A case report. ( 30762766 )
2019
11
CD30 expression in a case of intravascular large B-cell lymphoma, cutaneous variant. ( 30779218 )
2019
12
Intravascular large B-cell lymphoma: a forgotten stroke "mimic". ( 30848425 )
2019
13
A Study of PD-L1 Expression in Intravascular Large B-cell Lymphoma: Correlation with Clinical and Pathologic Features. ( 30938862 )
2019
14
A young woman with intravascular large B-cell lymphoma in a benign-appearing endometrial polyp. ( 31023746 )
2019
15
Multicentre retrospective study of intravascular large B-cell lymphoma treated at academic institutions within the United States. ( 31044423 )
2019
16
Severe peripheral oedema as the only presenting symptom of intravascular large B-cell lymphoma: a diagnosis too frequently made on autopsy. ( 31088816 )
2019
17
Did you "miss" me? A subtle case of intravascular large B-cell lymphoma. ( 29756305 )
2019
18
Intravascular large B-cell lymphoma as a cause of terminal acute respiratory distress syndrome: atypical presentation of a rare disease. ( 28444517 )
2018
19
Intravascular Large B-Cell Lymphoma Presenting with Diffuse Gallbladder Wall Thickening: A Case Report and Literature Review. ( 29850354 )
2018
20
Small Cell Variant of Intravascular Large B-Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis. ( 29850589 )
2018
21
Intravascular Large B-Cell Lymphoma Mimicking Temporal Arteritis. ( 29854538 )
2018
22
"Double-expressor" intravascular large B-cell lymphoma involving the female genital tract. ( 29954821 )
2018
23
Mortality in intravascular large B-cell lymphoma: A SEER analysis. ( 30092329 )
2018
24
Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks. ( 30111607 )
2018
25
Clinical value of abnormal findings on brain magnetic resonance imaging in patients with intravascular large B-cell lymphoma. ( 30141061 )
2018
26
Intravascular Large B-cell Lymphoma with a Pulmonary [18F]-Fluorodeoxyglucose Uptake. ( 30175729 )
2018
27
Intravascular large B-cell lymphoma presenting as multiple stroke: A case report. ( 30313105 )
2018
28
Intravascular large B-cell lymphoma presenting as an isolated cauda equina-conus medullaris syndrome - A case report. ( 30346252 )
2018
29
Intravascular Large B-Cell Lymphoma of the Kidney. ( 30450479 )
2018
30
CD5-Positive Intravascular Large B-Cell Lymphoma in a Patient with Wilson's Disease: Case Report and Review of the Literature. ( 30643658 )
2018
31
Intravascular large B-cell lymphoma: The Great Imitator. ( 30775328 )
2018
32
Intravascular large B-cell lymphoma presenting as a pituitary mass with bilateral adrenal enlargement and haemophagocytic lymphohistiocytosis. ( 28439895 )
2018
33
Intravascular large B-cell lymphoma presenting clinically as rapidly progressive dementia. ( 28726030 )
2018
34
Molecular classification of tumour cells in a patient with intravascular large B-cell lymphoma. ( 28733977 )
2018
35
Intravascular large B-cell lymphoma mimicking cerebral amyloid angiopathy-related inflammation. ( 29126561 )
2018
36
Rare Variant of Intravascular Large B-Cell Lymphoma With Hemophagocytic Syndrome. ( 29356737 )
2018
37
Random skin biopsy for diagnosis of intravascular large B-cell lymphoma in a patient with hypoxemia and normal lung imaging. ( 29387769 )
2018
38
Intravascular Large B-Cell Lymphoma of the Gallbladder. ( 29391332 )
2018
39
Autopsy case report of intravascular large B-cell lymphoma with neoplastic PD-L1 expression. ( 29415979 )
2018
40
Primary pulmonary intravascular large B-cell lymphoma: A report of three cases and literature review. ( 29467882 )
2018
41
Liquid biopsy for the identification of intravascular large B-cell lymphoma. ( 29472348 )
2018
42
High prevalence of MYD88 and CD79B mutations in intravascular large B-cell lymphoma. ( 29514783 )
2018
43
Intravascular large B-cell lymphoma presenting as panniculitis clinically: a case report. ( 29568849 )
2018
44
Increased uptake on 18 F-fluorodeoxyglucose positron emission tomography/computed tomography is indicative of occult skin lesions in a patient with intravascular large B-cell lymphoma. ( 29569289 )
2018
45
Intravascular Large B-Cell Lymphoma Within a Thyroid Nodule: A Diagnostic Pitfall. ( 29569516 )
2018
46
A rare case of suspected intravascular large B-cell lymphoma forming nodular masses in the brain and around the prostate and seminal vesicle. ( 29686966 )
2018
47
Serial chest CT findings of intravascular large B-cell lymphoma of the lungs. ( 29707378 )
2018
48
Recurrent Cytogenetic Abnormalities in Intravascular Large B-Cell Lymphoma. ( 29767679 )
2018
49
Methotrexate-associated Intravascular Large B-cell Lymphoma in a Patient with Rheumatoid Arthritis: A Very Rare Case. ( 29780139 )
2018
50
Orthodeoxia as a presentation of intravascular large B cell lymphoma. ( 29796279 )
2018

Variations for Intravascular Large B-Cell Lymphoma

Expression for Intravascular Large B-Cell Lymphoma

Search GEO for disease gene expression data for Intravascular Large B-Cell Lymphoma.

Pathways for Intravascular Large B-Cell Lymphoma

GO Terms for Intravascular Large B-Cell Lymphoma

Cellular components related to Intravascular Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 B2M CD5 IL2RB

Biological processes related to Intravascular Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.32 BCL2 BCL6
2 cell morphogenesis GO:0000902 9.26 BCL2 BCL6
3 positive regulation of B cell proliferation GO:0030890 9.16 BCL2 BCL6
4 cytokine-mediated signaling pathway GO:0019221 9.13 BCL2 BCL6 IL2RB
5 T cell differentiation in thymus GO:0033077 8.62 B2M BCL2

Molecular functions related to Intravascular Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.92 B2M BCL2 BCL6 KMT2A

Sources for Intravascular Large B-Cell Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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