MCID: INT104
MIFTS: 35

Intravascular Papillary Endothelial Hyperplasia

Categories: Rare diseases

Aliases & Classifications for Intravascular Papillary Endothelial Hyperplasia

MalaCards integrated aliases for Intravascular Papillary Endothelial Hyperplasia:

Name: Intravascular Papillary Endothelial Hyperplasia 53 73
Masson's Vegetant Intravascular Hemangio-Endothelioma 53
Masson's Pseudoangiosarcoma 53
Masson's Tumor 53

Classifications:



External Ids:

UMLS 73 C0343083

Summaries for Intravascular Papillary Endothelial Hyperplasia

NIH Rare Diseases : 53 Intravascular papillary endothelial hyperplasia (IPEH) is a benign overgrowth of endothelial cells (the cells lining blood vessels). The most frequent sites for IPEH are the deep vascular inner layers of skin (dermis and subcutis) of the head and neck regions and in the lip, tongue and buccal mucosa.  Rare locations include the thyroid, eye (orbit), parotid gland, muscles involved in chewing (masseter muscle), nose, sinus, mandible, pharynx and central nervous system.  The average age of onset is 34.  Signs and symptoms depend on the location of the IPEH.  A definitive diagnosis is made by biopsy of the tumor and examination of the specimen by a pathologist.  Treatment usually involves removal of the tumor by surgery.  Recurrences are very rare.

MalaCards based summary : Intravascular Papillary Endothelial Hyperplasia, also known as masson's vegetant intravascular hemangio-endothelioma, is related to angiosarcoma and pyogenic granuloma. An important gene associated with Intravascular Papillary Endothelial Hyperplasia is VIM (Vimentin), and among its related pathways/superpathways are HIF-1 signaling pathway and Signaling events mediated by VEGFR1 and VEGFR2. Affiliated tissues include endothelial, skin and thyroid, and related phenotype is muscle.

Wikipedia : 76 Intravascular papillary endothelial hyperplasia (also known as \"Masson\'s hemangio-endotheliome... more...

Related Diseases for Intravascular Papillary Endothelial Hyperplasia

Diseases related to Intravascular Papillary Endothelial Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 30.4 VEGFA VIM
2 pyogenic granuloma 30.2 ACTC1 VEGFA
3 hemangioma 29.9 ACTC1 VEGFA
4 adenoid cystic carcinoma 28.9 ACTC1 SERPINA3 VIM
5 endotheliitis 11.0
6 lymphangiectasis 10.3 ACTC1 VIM
7 glomangiomyoma 10.3 ACTC1 VIM
8 angiolipoma 10.3 ACTC1 VIM
9 spindle cell lipoma 10.3 ACTC1 VIM
10 parachordoma 10.3 ACTC1 VIM
11 ossifying fibromyxoid tumor 10.3 ACTC1 VIM
12 syringocystadenoma papilliferum 10.3 ACTC1 VIM
13 benign metastasizing leiomyoma 10.3 ACTC1 VIM
14 adenofibroma 10.3 ACTC1 VIM
15 congenital fibrosarcoma 10.3 ACTC1 VIM
16 angiocentric glioma 10.3 ACTC1 VIM
17 pleomorphic liposarcoma 10.3 ACTC1 VIM
18 perivascular epithelioid cell tumor 10.3 ACTC1 VIM
19 reticulum cell sarcoma 10.3 ACTC1 VIM
20 glomus tumor 10.3 ACTC1 VIM
21 pseudosarcomatous fibromatosis 10.3 ACTC1 VIM
22 dendritic cell tumor 10.3 ACTC1 VIM
23 rhabdoid cancer 10.3 ACTC1 VIM
24 smooth muscle tumor 10.3 ACTC1 VIM
25 hemangiopericytoma, malignant 10.3 ACTC1 VIM
26 peliosis hepatis 10.3 VEGFA VIM
27 granulosa cell tumor of the ovary 10.3 ACTC1 VIM
28 polymorphous low-grade adenocarcinoma 10.3 ACTC1 VIM
29 infantile myofibromatosis 10.3 ACTC1 VIM
30 aneurysm 10.2
31 chondromyxoid fibroma 10.2 ACTC1 VIM
32 fasciitis 10.2 ACTC1 VIM
33 glomangioma 10.2 ACTC1 VIM
34 fibromatosis 10.2 ACTC1 VIM
35 ameloblastic carcinoma 10.2 HIF1A VIM
36 myoepithelioma 10.2 ACTC1 VIM
37 sarcoma 10.2
38 spindle cell carcinoma 10.2 ACTC1 VIM
39 lymphangioma 10.2 ACTC1 VEGFA
40 juvenile nasopharyngeal angiofibroma 10.2 ACTC1 VEGFA
41 atypical teratoid rhabdoid tumor 10.2 ACTC1 VIM
42 critical limb ischemia 10.1 HIF1A VEGFA
43 cystadenocarcinoma 10.1 VEGFA VIM
44 inflammatory myofibroblastic tumor 10.1 ACTC1 VIM
45 pleomorphic adenoma 10.1 ACTC1 VIM
46 retinal ischemia 10.0 HIF1A VEGFA
47 leiomyosarcoma 10.0 ACTC1 VIM
48 acute mountain sickness 10.0 HIF1A VEGFA
49 pericardial effusion 10.0 HIF1A VEGFA
50 limb ischemia 10.0 HIF1A VEGFA

Graphical network of the top 20 diseases related to Intravascular Papillary Endothelial Hyperplasia:



Diseases related to Intravascular Papillary Endothelial Hyperplasia

Symptoms & Phenotypes for Intravascular Papillary Endothelial Hyperplasia

MGI Mouse Phenotypes related to Intravascular Papillary Endothelial Hyperplasia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.92 ACTC1 HIF1A VEGFA VIM

Drugs & Therapeutics for Intravascular Papillary Endothelial Hyperplasia

Search Clinical Trials , NIH Clinical Center for Intravascular Papillary Endothelial Hyperplasia

Genetic Tests for Intravascular Papillary Endothelial Hyperplasia

Anatomical Context for Intravascular Papillary Endothelial Hyperplasia

MalaCards organs/tissues related to Intravascular Papillary Endothelial Hyperplasia:

41
Endothelial, Skin, Thyroid, Eye, Tongue, Bone, Kidney

Publications for Intravascular Papillary Endothelial Hyperplasia

Articles related to Intravascular Papillary Endothelial Hyperplasia:

(show top 50) (show all 158)
# Title Authors Year
1
Sinusoidal hemangioma and intravascular papillary endothelial hyperplasia: Interrelated processes that share a histogenetic piecemeal angiogenic mechanism. ( 29486986 )
2018
2
A mixed form of intravascular papillary endothelial hyperplasia in an uncommon location: case and literature review. ( 29630155 )
2018
3
An intravascular papillary endothelial hyperplasia of the hand radiologically mimicking a hemangiopericytoma: A case report and literature review. ( 29348916 )
2018
4
Intravascular Papillary Endothelial Hyperplasia of the Foot. ( 29102481 )
2018
5
Intravascular Papillary Endothelial Hyperplasia as an unusual diagnosis for peri-orbital tumour - A case report. ( 29283152 )
2018
6
Intravascular Papillary Endothelial Hyperplasia at Foot Level: A Case Report and Literature Review. ( 27989349 )
2017
7
Extravascular type of intravascular papillary endothelial hyperplasia mimicking parotid gland neoplasia and the possible role of ferritin in the pathogenesis: A case report. ( 28357092 )
2017
8
Intravascular Papillary Endothelial Hyperplasia (Masson's Tumor): Diagnosis the Plastic Surgeon Should Be Aware of. ( 28203491 )
2017
9
Intravascular Papillary Endothelial Hyperplasia Presenting as a Cystic Mass in the Scalp with Underlying Bone Involvement: A Rare Entity. ( 29308369 )
2017
10
Intravascular Papillary Endothelial Hyperplasia (Masson's Tumor) of the Hand. ( 28205488 )
2017
11
Intravascular Papillary Endothelial Hyperplasia of the Jejunum as a Cause of Obscure-Overt Gastrointestinal Bleeding. ( 28670594 )
2017
12
The first recurrent intravascular papillary endothelial hyperplasia (Masson's tumor) of the kidney. ( 27635297 )
2016
13
Intravascular papillary endothelial hyperplasia of the vulva: report of a patient with Masson tumor of the vulva and literature review. ( 27617519 )
2016
14
Intravascular papillary endothelial hyperplasia: magnetic resonance imaging of finger lesions. ( 26603891 )
2016
15
Intravascular Papillary Endothelial Hyperplasia (Masson's Tumor) of the Radial Artery: A Case Report. ( 27402306 )
2016
16
Imaging characteristics of intravascular papillary endothelial hyperplasia. ( 27538971 )
2016
17
Oral Intravascular Papillary Endothelial Hyperplasia Associated with an Organizing Thrombus: Case Report and Immunohistochemical Analysis. ( 28053797 )
2016
18
Co-existence of Intravascular Papillary Endothelial Hyperplasia in Superficial Skin and the Intermuscular Space. ( 27384262 )
2016
19
Intrahepatic Masson tumor (intravascular papillary endothelial hyperplasia). ( 27863692 )
2016
20
A case of intravascular papillary endothelial hyperplasia of the stomach leading to a novel hypothesis for the pathogenesis. ( 27676691 )
2016
21
Intravascular Papillary Endothelial Hyperplasia of Palate. ( 27671193 )
2016
22
Intravascular papillary endothelial hyperplasia (IPEH). Evidence supporting a piecemeal mode of angiogenesis from vein endothelium, with vein wall neovascularization and papillary formation. ( 27323848 )
2016
23
Intravascular papillary endothelial hyperplasia: An unusual histopathological entity. ( 26225335 )
2015
24
Intravascular papillary endothelial hyperplasia (Masson tumor) mimicking a sarcoma and developing from an arteriovenous hemodialysis fistula. ( 25427786 )
2015
25
Subcutaneous intravascular papillary endothelial hyperplasia: ultrasound features and pathological correlation. ( 26559670 )
2015
26
Extra-vascular type of oral intravascular papillary endothelial hyperplasia (Masson's tumor) of lower lip: a case report and review of the literature. ( 25961626 )
2015
27
Intravascular Papillary Endothelial Hyperplasia as an Aneurysm of the Brachial Artery. ( 25637575 )
2015
28
Intravascular papillary endothelial hyperplasia: Sonographic and magnetic resonance imaging appearance with histopathologic correlation. ( 26318620 )
2015
29
Thirteen-year follow-up of parasellar intravascular papillary endothelial hyperplasia successfully treated by surgical excision: case report. ( 25580513 )
2015
30
Intravascular papillary endothelial hyperplasia of larynx: case report and literature review of all head and neck cases. ( 24981303 )
2014
31
Subacute presentation of eyebrow intravascular papillary endothelial hyperplasia causing ophthalmic nerve compression. ( 25112660 )
2014
32
Radiological imaging of florid intravascular papillary endothelial hyperplasia in the mandibule: case report and literature review. ( 24461559 )
2014
33
Intravascular papillary endothelial hyperplasia (Masson's tumor) of the scalp with intracranial extension. ( 25624932 )
2014
34
Intravascular Papillary Endothelial Hyperplasia Presenting in a Mohs Surgical Scar. ( 25365358 )
2014
35
Intravascular papillary endothelial hyperplasia: diagnostic sequence and literature review of an orofacial lesion. ( 24891960 )
2014
36
Intravascular papillary endothelial hyperplasia of the chest wall misdiagnosed as a malignancy on fine needle aspiration. ( 24255643 )
2013
37
HIF-1I+ and VEGF expression correlates with thrombus remodeling in cases of intravascular papillary endothelial hyperplasia. ( 24294378 )
2013
38
Intravascular papillary endothelial hyperplasia of the skull base and intracranial compartment. ( 23927814 )
2013
39
Intravascular papillary endothelial hyperplasia of the digit: MRI features with histological correlation. ( 22759484 )
2013
40
Intravascular papillary endothelial hyperplasia (Masson's tumour) in the vulva. ( 23642911 )
2013
41
Intravascular papillary endothelial hyperplasia: histomorphological and immunohistochemical features. ( 24125024 )
2013
42
Intravascular papillary endothelial hyperplasia diagnosed by fine needle aspiration: Report of a case and cytology literature review. ( 23661940 )
2013
43
Destructive radiologic development of intravascular papillary endothelial hyperplasia on skull bone. ( 22993678 )
2012
44
Intravascular Papillary Endothelial Hyperplasia (Masson tumor) of the Skull : Case Report and Literature Review. ( 22993679 )
2012
45
Intravascular papillary endothelial hyperplasia of the internal auditory canal. ( 22072306 )
2012
46
Pathology quiz case 1. Diagnosis: Intravascular papillary endothelial hyperplasia (IPEH). ( 23165390 )
2012
47
Intravascular papillary endothelial hyperplasia of the palate masquerading as adenoid cystic carcinoma on fine needle aspiration cytology: a potential diagnostic pitfall. ( 21385237 )
2012
48
Successful treatment of intravascular papillary endothelial hyperplasia (IPEH) by the beta-adrenergic antagonist nebivolol. ( 22122809 )
2012
49
Orbital intravascular papillary endothelial hyperplasia in a Nigerian child: a case report and review of the literature. ( 22974134 )
2012
50
Cytologic diagnosis of intravascular papillary endothelial hyperplasia: a report of two cases and review of cytologic literature. ( 22378085 )
2012

Variations for Intravascular Papillary Endothelial Hyperplasia

Expression for Intravascular Papillary Endothelial Hyperplasia

Search GEO for disease gene expression data for Intravascular Papillary Endothelial Hyperplasia.

Pathways for Intravascular Papillary Endothelial Hyperplasia

GO Terms for Intravascular Papillary Endothelial Hyperplasia

Cellular components related to Intravascular Papillary Endothelial Hyperplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.62 SERPINA3 VEGFA

Biological processes related to Intravascular Papillary Endothelial Hyperplasia according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.71 ACTC1 HIF1A VEGFA
2 cytokine-mediated signaling pathway GO:0019221 9.58 HIF1A VEGFA VIM
3 platelet degranulation GO:0002576 9.56 SERPINA3 VEGFA
4 cellular response to hypoxia GO:0071456 9.55 HIF1A VEGFA
5 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.52 HIF1A VEGFA
6 positive regulation of endothelial cell proliferation GO:0001938 9.51 HIF1A VEGFA
7 outflow tract morphogenesis GO:0003151 9.49 HIF1A VEGFA
8 positive regulation of blood vessel endothelial cell migration GO:0043536 9.48 HIF1A VEGFA
9 lactation GO:0007595 9.46 HIF1A VEGFA
10 muscle filament sliding GO:0030049 9.43 ACTC1 VIM
11 dopaminergic neuron differentiation GO:0071542 9.37 HIF1A VEGFA
12 camera-type eye morphogenesis GO:0048593 9.32 HIF1A VEGFA
13 positive regulation of neuroblast proliferation GO:0002052 9.26 HIF1A VEGFA
14 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.16 HIF1A VEGFA
15 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 8.96 HIF1A VEGFA
16 positive regulation of gene expression GO:0010628 8.92 ACTC1 HIF1A VEGFA VIM

Sources for Intravascular Papillary Endothelial Hyperplasia

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