MCID: INT020
MIFTS: 34

Intravenous Leiomyomatosis

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Intravenous Leiomyomatosis

MalaCards integrated aliases for Intravenous Leiomyomatosis:

Name: Intravenous Leiomyomatosis 12 53 15 73
Leiomyomatosis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5729
NCIt 50 C4518 C5356
SNOMED-CT 68 254883003
UMLS 73 C0346200

Summaries for Intravenous Leiomyomatosis

NIH Rare Diseases : 53 Intravenous leiomyomatosis (IVL) is a benign smooth muscle tumor of the uterus that grows within the veins but does not invade the surrounding tissue. IVL usually starts in the veins of the uterus and can extend into the inferior vena cava and ultimately into the right side of the heart, resulting in death The abnormal smooth muscle cells that cause IVL express estrogen and progesterone receptors and tumor growth thus appears to respond to these hormones. Although this is a benign condition, many affected individuals require surgery to remove the excess tissue in the uterus and heart. The exact cause of IVL remains unknown. IVL is rare, with only about 200 cases reported in the medical literature.

MalaCards based summary : Intravenous Leiomyomatosis, also known as leiomyomatosis, is related to smooth muscle tumor and leiomyoma. An important gene associated with Intravenous Leiomyomatosis is ESR1 (Estrogen Receptor 1), and among its related pathways/superpathways are Pathways in cancer and Thyroid hormone signaling pathway. The drugs Ethanol and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include uterus, heart and smooth muscle.

Wikipedia : 76 Intravenous leiomyomatosis is a rare condition seen exclusively in women in which leiomyomata, benign... more...

Related Diseases for Intravenous Leiomyomatosis

Graphical network of the top 20 diseases related to Intravenous Leiomyomatosis:



Diseases related to Intravenous Leiomyomatosis

Symptoms & Phenotypes for Intravenous Leiomyomatosis

Drugs & Therapeutics for Intravenous Leiomyomatosis

Drugs for Intravenous Leiomyomatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4 64-17-5 702
2
Acetylcholine Approved Phase 2 51-84-3 187
3
Metformin Approved Phase 1, Phase 2 657-24-9 14219 4091
4
Bevacizumab Approved, Investigational Phase 2 216974-75-3
5
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
6 abobotulinumtoxinA Phase 2
7 Cholinergic Agents Phase 2
8 Neuromuscular Agents Phase 2
9 Neurotransmitter Agents Phase 2
10 onabotulinumtoxinA Phase 2
11 Peripheral Nervous System Agents Phase 2
12 Botulinum Toxins, Type A Phase 2
13 Botulinum Toxins Phase 2
14
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
15 Angiogenesis Inhibitors Phase 2
16 Angiogenesis Modulating Agents Phase 2
17 Hypoglycemic Agents Phase 1, Phase 2
18 Protein Kinase Inhibitors Phase 2
19 Antimetabolites Phase 2
20 Antimetabolites, Antineoplastic Phase 2
21
Progesterone Approved, Vet_approved 57-83-0 5994

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE) Completed NCT00628901 Phase 4
2 Efficacy and Safety of Rapamycin (Sirolimus) in the Treatment of Symptomatic Uterine Fibroids and Leiomyomatosis Recruiting NCT03500367 Phase 4 rapamycin
3 Randomized Pilot Study for the Treatment of Cutaneous Leiomyomas With Botulinum Toxin Completed NCT00971620 Phase 2
4 A Phase II Study of Bevacizumab and Erlotinib in Subjects With Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell Cancer Recruiting NCT01130519 Phase 2 Bevacizumab;Erlotinib
5 Vandetanib in Combination With Metformin in People With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell Carcinoma Recruiting NCT02495103 Phase 1, Phase 2 Vandetanib;Metformin;Vandetanib/Metformin
6 A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase Deficiency and HLRCC-associated Kidney Cancer Recruiting NCT03165721 Phase 2 SGI-110 (guadecitabine)
7 Comparison Study in the Treatment of Uterine Fibroids Uterine Fibroid Embolization Using BeadBlock™ Embolic Agent Completed NCT00361036 Phase 1
8 Surgery for Intravenous Leiomyomatosis Completed NCT01707862
9 Official Record of Patients Diagnosed With Lymphangioleiomyomatosis (LAM) Completed NCT00001869
10 Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer Recruiting NCT00050752
11 French National Registry of Rare Peritoneal Surface Malignancies Active, not recruiting NCT02834169
12 Establishment of Fibroid Tissue Bank Terminated NCT00710346

Search NIH Clinical Center for Intravenous Leiomyomatosis

Genetic Tests for Intravenous Leiomyomatosis

Anatomical Context for Intravenous Leiomyomatosis

MalaCards organs/tissues related to Intravenous Leiomyomatosis:

41
Uterus, Heart, Smooth Muscle, Kidney

Publications for Intravenous Leiomyomatosis

Articles related to Intravenous Leiomyomatosis:

(show top 50) (show all 210)
# Title Authors Year
1
Intravenous leiomyomatosis of the uterus: A clinicopathologic analysis of 13 cases with an emphasis on histogenesis. ( 29699902 )
2018
2
Intravenous leiomyomatosis with intracardiac extension. ( 29048548 )
2018
3
Contrast-enhanced CT findings of intravenous leiomyomatosis. ( 29395222 )
2018
4
A Novel Diagnostic Strategy Using 16I+-[18F]-Fluoro-17-I^-Estradiol (18F-FES) PET/MRI to Achieve Complete Resection of Intravenous Leiomyomatosis in Reproductive-Age Women. ( 28481790 )
2017
5
Intravenous leiomyomatosis of the subclavian vein. ( 28214494 )
2017
6
Intravenous leiomyomatosis of the uterus: A clinicopathological analysis of nine cases and literature review. ( 28600049 )
2017
7
Post-hysterectomy intravenous leiomyomatosis: A case of successful multidisciplinary surgery under non-extracorporeal circulation. ( 28123726 )
2017
8
Anestheic Management of a Patient with Intravenous Leiomyomatosis Extending into the Right Atrium. ( 29693945 )
2017
9
Intracardiac Extension of Intravenous Leiomyomatosis. ( 28109375 )
2017
10
Radio-surgical and pathologic correlations of pelvic intravenous leiomyomatosis. ( 28643137 )
2017
11
Intravenous Leiomyomatosis Extending from the Pelvic Veins to the Heart. ( 28479243 )
2017
12
Clinical characteristics and prognostic features of intravenous leiomyomatosis with inferior vena cava orA intracardiac extension. ( 28623982 )
2017
13
Management of Intravenous Leiomyomatosis of Uterus with Extension to Heart. ( 26838087 )
2016
14
The value of (18)F-FDG PET/CT in the diagnosis of uterine intravenous leiomyomatosis extended into the right atrium. ( 27331217 )
2016
15
Surgical Treatment of Intracardiac-Extending Intravenous Leiomyomatosis: A Single Center Experience. ( 27355139 )
2016
16
Successful One Stage Surgical Removal of Intravenous Leiomyomatosis with On Pump Beating Heart Technique. ( 26847505 )
2016
17
Vanishing intravenous leiomyomatosis after hysterectomy: Assessment of the need to perform complete resection. ( 27080990 )
2016
18
Intravenous leiomyomatosis with intracardiac extension depicted on computed tomography and magnetic resonance imaging scans: A report of two cases and a review of the literature. ( 27313775 )
2016
19
Uterine Intravenous Leiomyomatosis with Intracardiac Extension and Pulmonary Benign Metastases on FDG PET/CT: A Case Report. ( 26957916 )
2016
20
Pelvic Intravenous Leiomyomatosis - Case Report. ( 27529764 )
2016
21
Surgical Treatment Strategies of Intravenous Leiomyomatosis withRight Cardiac Cavities Extension. ( 27594158 )
2016
22
Intravenous leiomyomatosis with inferior vena cava or intracardiac extension and concurrent bilateral multiple pulmonary nodules: A report of 2 cases. ( 27583911 )
2016
23
Factors Associated With Recurrence After Surgical Resection in Women With Intravenous Leiomyomatosis. ( 27741175 )
2016
24
Intravenous Leiomyomatosis in the Parametrium. ( 26802907 )
2016
25
Intravenous leiomyomatosis with right atrium extension in two patients: A case report. ( 27900095 )
2016
26
Intravenous leiomyomatosis: an unusual growth pattern in uterine myomas. ( 26850648 )
2016
27
Successful One-Stage Operative Resection of an Intravenous Leiomyomatosis Involving the Right-Sided Heart Chambers and Pulmonary Artery. ( 27146232 )
2016
28
Intravenous leiomyomatosis treated with radical hysterectomy and adjuvant aromatase inhibitor therapy. ( 27436168 )
2016
29
Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors. ( 26892441 )
2016
30
Different surgical strategies of patients with intravenous leiomyomatosis. ( 27631266 )
2016
31
Intravenous leiomyomatosis disguised as a large deep vein thrombosis. ( 27761178 )
2016
32
Paradoxical Tumor Embolism and Recurrent Intracardiac Mass From Uterine Intravenous Leiomyomatosis. ( 27554224 )
2016
33
Extension of uterine intravenous leiomyomatosis to the right heart. ( 26719238 )
2015
34
Preoperative Echocardiography First Diagnosed and Intraoperative Echocardiography Altered the Surgical Plan in Intravenous Leiomyomatosis. ( 26119406 )
2015
35
Post hysterectomy intravenous leiomyomatosis: multimodality imaging appearances. ( 26248786 )
2015
36
Treatment of Intravenous Leiomyomatosis with Cardiac Extension following Incomplete Resection. ( 26783463 )
2015
37
Multimodality Evaluation of Intravenous Leiomyomatosis: A Rare, Benign but Potentially Life-Threatening Tumor. ( 26546569 )
2015
38
Intravenous leiomyomatosis with intracardiac extension: an unusual presentation of uterine leiomyoma and evaluation with 256-slice dual-source multidetector CT and cardiac MRI. ( 26643185 )
2015
39
Orthostatic hypotension and right heart failure as the initial manifestation of intravenous leiomyomatosis. ( 26282248 )
2015
40
Uterine Intravenous Leiomyomatosis with Cardiac Extension: Radiologic Assessment with Surgical and Pathologic Correlation. ( 26236515 )
2015
41
A rare case of recurrent intravenous leiomyomatosis: Role of GnRH analogues? ( 26838010 )
2015
42
Intravenous leiomyomatosis revisited: an experience of 14 cases at a single medical center. ( 25675187 )
2015
43
Successful multiple-step management of intravenous leiomyomatosis diagnosed after episode of acute abdominal pain: Case report and review of literature. ( 26282558 )
2015
44
Single-stage operation using hypothermic circulatory arrest to remove uterine intravenous leiomyomatosis extended to the vena cava and right atrium. ( 25579748 )
2015
45
Computerized tomography angiography in preoperative assessment of intravenous leiomyomatosis extending to inferior vena cava and heart. ( 26858203 )
2015
46
Intravenous leiomyomatosis with cardiac extension. ( 25698394 )
2015
47
Recurrent chromosomal aberrations in intravenous leiomyomatosis of the uterus: high-resolution array comparative genomic hybridization study. ( 25033729 )
2014
48
Intravenous leiomyomatosis: a rare cause of intracardiac mass. ( 25455948 )
2014
49
Intravenous leiomyomatosis with intracardiac extension: echocardiographic study and literature review. ( 25425982 )
2014
50
Intravenous leiomyomatosis with intracardiac involvement. ( 24838291 )
2014

Variations for Intravenous Leiomyomatosis

Expression for Intravenous Leiomyomatosis

Search GEO for disease gene expression data for Intravenous Leiomyomatosis.

Pathways for Intravenous Leiomyomatosis

Pathways related to Intravenous Leiomyomatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.52 ESR1 PIK3R3 PTCH2
2 11.22 ESR1 PIK3R3
3 10.94 ESR1 PIK3R3

GO Terms for Intravenous Leiomyomatosis

Biological processes related to Intravenous Leiomyomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phosphorylation GO:0046854 8.62 ESR1 PIK3R3

Sources for Intravenous Leiomyomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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