MCID: INT040
MIFTS: 37

Intrinsic Asthma

Categories: Respiratory diseases

Aliases & Classifications for Intrinsic Asthma

MalaCards integrated aliases for Intrinsic Asthma:

Name: Intrinsic Asthma 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9360
ICD10 33 J45
ICD9CM 35 493.1
UMLS 73 C0155880

Summaries for Intrinsic Asthma

Disease Ontology : 12 An asthma that is triggered by factors not related to allergies such as anxiety, stress, exercise, cold air, dry air, hyperventilation, smoke, viruses, chemical irritants, autonomic imbalance, hormonal deficiencies and psychogenic influences. It is characterized by airway obstruction and inflammation that is at least partially reversible with medication. The symptoms include coughing, wheezing, shortness of breath or rapid breathing, and chest tightness.

MalaCards based summary : Intrinsic Asthma is related to sinusitis and bronchitis. An important gene associated with Intrinsic Asthma is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Omalizumab and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, testes and lung.

Related Diseases for Intrinsic Asthma

Diseases related to Intrinsic Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 sinusitis 29.9 IL5 RNASE3
2 bronchitis 29.8 IL5 RNASE3
3 rhinitis 29.6 IL4 IL5 RNASE3
4 allergic asthma 29.4 IL4 IL5 RNASE3
5 asthma 29.0 FCER2 IL3 IL4 IL5 RNASE3
6 egg allergy 10.5 IL4 IL5
7 scleritis 10.5 IL4 IL5
8 angiostrongyliasis 10.5 IL4 IL5
9 trichinosis 10.5 IL4 IL5
10 apple allergy 10.5 IL4 IL5
11 non-suppurative otitis media 10.5 IL4 IL5
12 eosinophilic meningitis 10.5 IL4 IL5
13 b-cell growth factor 10.5 IL3 IL4
14 cercarial dermatitis 10.5 IL4 IL5
15 intestinal schistosomiasis 10.5 IL4 IL5
16 chronic tic disorder 10.5 IL4 IL5
17 folliculitis 10.4 IL4 IL5
18 seborrheic infantile dermatitis 10.4 IL3 IL5
19 primary amebic meningoencephalitis 10.4 IL4 IL5
20 allergic bronchopulmonary aspergillosis 10.4 IL4 IL5
21 enterobiasis 10.4 IL4 IL5
22 hypereosinophilic syndrome, idiopathic 10.4 IL3 IL5
23 blepharoconjunctivitis 10.4 IL4 RNASE3
24 paranasal sinus disease 10.4 IL4 IL5
25 giant papillary conjunctivitis 10.4 IL4 RNASE3
26 loeffler endocarditis 10.4 IL5 RNASE3
27 paracoccidioidomycosis 10.3 IL4 IL5
28 cow milk allergy 10.3 IL5 RNASE3
29 paragonimiasis 10.3 IL5 RNASE3
30 allergic contact dermatitis 10.3 IL4 IL5
31 chronic eosinophilic pneumonia 10.3 IL5 RNASE3
32 aspergillosis 10.3 IL4 IL5
33 persistent polyclonal b-cell lymphocytosis 10.3 FCER2 IL4
34 status asthmaticus 10.3 IL5 RNASE3
35 contact dermatitis 10.3 IL4 IL5
36 cellulitis 10.3 IL5 RNASE3
37 sezary's disease 10.2 IL4 IL5
38 ocular cicatricial pemphigoid 10.2 IL4 RNASE3
39 wells syndrome 10.2 IL5 RNASE3
40 vernal conjunctivitis 10.2 IL4 RNASE3
41 hypersensitivity reaction disease 10.2 IL4 IL5
42 churg-strauss syndrome 10.2 IL5 RNASE3
43 common cold 10.2 IL5 RNASE3
44 eosinophilic gastritis 10.1 IL3 IL4 IL5
45 tetanus 10.0 IL4 IL5
46 immune system disease 10.0 IL3 IL4 IL5
47 cough variant asthma 10.0 IL4 IL5 RNASE3
48 inflammatory bowel disease 4 10.0 IL4 IL5 RNASE3
49 latex allergy 10.0 IL4 IL5 RNASE3
50 gastrointestinal allergy 10.0 IL4 IL5 RNASE3

Graphical network of the top 20 diseases related to Intrinsic Asthma:



Diseases related to Intrinsic Asthma

Symptoms & Phenotypes for Intrinsic Asthma

Drugs & Therapeutics for Intrinsic Asthma

Drugs for Intrinsic Asthma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 2,Not Applicable 242138-07-4
2 Neurotransmitter Agents Phase 1, Phase 2,Not Applicable
3 Methacholine Chloride Phase 1, Phase 2
4 Respiratory System Agents Phase 1, Phase 2,Phase 2,Not Applicable
5 Cholinergic Agents Phase 1, Phase 2
6 Peripheral Nervous System Agents Phase 1, Phase 2
7 Autonomic Agents Phase 1, Phase 2
8 Anti-Allergic Agents Phase 2,Not Applicable
9 Anti-Asthmatic Agents Phase 2,Not Applicable
10
Levocetirizine Approved Not Applicable 130018-77-8 1549000
11
Histamine Approved, Investigational Not Applicable 75614-87-8, 51-45-6 774
12
Menthol Approved Not Applicable 2216-51-5 16666
13
Histamine Phosphate Not Applicable 51-74-1 65513
14 Histamine Antagonists Not Applicable
15 Histamine H1 Antagonists Not Applicable
16 Histamine H1 Antagonists, Non-Sedating Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 PEEP as Rescue Therapy for Asthmatics With Elevated BMI Recruiting NCT02696980 Phase 1, Phase 2
2 Effect of Anti-IgE in Non-Allergic Asthma Terminated NCT00162773 Phase 2 omalizumab
3 Characterization of the Role of Histamine in Children With Asthma Unknown status NCT01392859 Not Applicable levocetirizine
4 Glasgow Asthma and Allergy Study Completed NCT01618318
5 Inflammatory Markers in Exhaled Breath Condensates From Asthmatic Patients Completed NCT01246414
6 Asthma Inflammation Research Active, not recruiting NCT01536522 Not Applicable
7 Genetic Study of Familial Forms of Non-atopic Asthma Not yet recruiting NCT02911220 Not Applicable
8 Soluble CD23 Expression in Asthma Patients Treated With OMA Terminated NCT00226200 Not Applicable Omalizumab
9 The Long-term Prognosis of Moderate to Severe Bronchial Hyperresponsiveness (BHR) in Asthmatic Preschool Children Withdrawn NCT01144910

Search NIH Clinical Center for Intrinsic Asthma

Genetic Tests for Intrinsic Asthma

Anatomical Context for Intrinsic Asthma

MalaCards organs/tissues related to Intrinsic Asthma:

41
Neutrophil, Testes, Lung, Smooth Muscle

Publications for Intrinsic Asthma

Articles related to Intrinsic Asthma:

(show top 50) (show all 81)
# Title Authors Year
1
Asthma phenotypes: nonallergic (intrinsic) asthma. ( 25439352 )
2014
2
Novel diagnostic approaches and biological therapeutics for intrinsic asthma. ( 25031543 )
2014
3
Against all odds: anti-IgE for intrinsic asthma? ( 23709757 )
2014
4
Presence in sputum of functional dust mite-specific IgE antibodies in intrinsic asthma. ( 21474647 )
2011
5
Intrinsic asthma: is it intrinsic to the smooth muscle? ( 19438582 )
2009
6
Is intrinsic asthma synonymous with infection? ( 19638039 )
2009
7
Intrinsic asthma: not so different from allergic asthma but driven by superantigens? ( 19538350 )
2009
8
Non-atopic intrinsic asthma and the 'family tree' of chronic respiratory disease syndromes. ( 19400902 )
2009
9
Mechanisms of intrinsic asthma. ( 15090920 )
2004
10
Low levels of immunoglobulin A in children with intrinsic asthma: a possible protection against atopy. ( 15050114 )
2004
11
[Intrinsic asthma]. ( 12843993 )
2003
12
Triggers in intrinsic asthma in the EGEA study. ( 12699216 )
2003
13
Increase in perforin-positive peripheral blood lymphocytes in extrinsic and intrinsic asthma. ( 10619818 )
2000
14
Esophageal dysmotility and gastroesophageal reflux in intrinsic asthma. ( 9201082 )
1997
15
Is there a place for intrinsic asthma as a distinct immunopathological entity? ( 9072976 )
1997
16
Selenium status is decreased in patients with intrinsic asthma. ( 8811281 )
1996
17
Plasma zinc, copper and copper/zinc ratio in intrinsic asthma. ( 8793823 )
1996
18
Extrinsic and intrinsic asthma from childhood to adult age: a 10-yr follow-up. ( 7480988 )
1995
19
Phenotypes of alpha-1-antitrypsin in intrinsic asthma and ASA-triad patients. ( 7631591 )
1995
20
Soluble CD23 (sCD23) serum levels and lymphocyte subpopulations in peripheral blood in rhinitis and extrinsic and intrinsic asthma. ( 7653734 )
1994
21
The immunology of extrinsic and intrinsic asthma. ( 8368174 )
1993
22
Selenium supplementation in intrinsic asthma. ( 8457023 )
1993
23
Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness. ( 1489147 )
1992
24
Correlation between blood eosinophils, T-helper cell activity markers and pulmonary function in patients with allergic and intrinsic asthma. ( 1342912 )
1992
25
Is intrinsic asthma a hereditary disease? ( 1928660 )
1991
26
Intrinsic asthma: myth or reality? ( 1741928 )
1991
27
Lowered platelet glutathione peroxidase activity in patients with intrinsic asthma. ( 2252163 )
1990
28
Serum E. coli antibodies as a parameter of peripheral immune function in intrinsic asthma. ( 2133896 )
1990
29
Long-term multicentric study with azelastine in patients with intrinsic asthma. ( 2085334 )
1990
30
Nonallergic rhinitis with eosinophilia syndrome a precursor of the triad: nasal polyposis, intrinsic asthma, and intolerance to aspirin. ( 2346237 )
1990
31
Etiology of intrinsic asthma. ( 2683626 )
1989
32
Is there a biochemical lesion in intrinsic asthma? ( 2683623 )
1989
33
Immunological aspects of extrinsic and intrinsic asthma. ( 2816568 )
1989
34
Antiinflammatory therapy with glucocorticoids in intrinsic asthma. ( 2683633 )
1989
35
Influenza A virus enhances Staphylococcus aureus-induced basophil histamine release in normal individuals and patients with intrinsic asthma. ( 2470268 )
1989
36
Inhibition of fog-induced bronchoconstriction by nedocromil sodium and sodium cromoglycate in intrinsic asthma: a double-blind, placebo-controlled study. ( 2554440 )
1989
37
Introductory remarks: International Symposium on Intrinsic Asthma. ( 2816572 )
1989
38
The eosinophil and intrinsic asthma. ( 2683640 )
1989
39
The role of viral infections in intrinsic asthma: activation of neutrophil inflammation. ( 2554699 )
1989
40
Serum kininases I and II in patients with extrinsic and intrinsic asthma. ( 2557756 )
1989
41
Basic aspects of therapy in intrinsic asthma. ( 2683631 )
1989
42
Intrinsic asthma. Proceedings of the 4th international symposium. Hochgebirgsklinik Davos, September 18-20, 1988. ( 2816565 )
1989
43
Influenza A virus potentiates basophil histamine release caused by endotoxin-induced complement activation. Examination of normal individuals and patients with intrinsic asthma. ( 2452582 )
1988
44
Additive effects of isoproterenol-phenylephrine aerosol following ipratropium bromide on airway obstruction in older patients with intrinsic asthma and chronic bronchitis. ( 2943921 )
1986
45
Intrinsic asthma and bacterial histamine release via lectin effect. ( 6191549 )
1983
46
Intrinsic asthma and bacterial histamine release. Possible role of bacterial surface lectins. ( 6193996 )
1983
47
Studies on hypersensitivity to bacterial antigens in intrinsic asthma. ( 6182815 )
1982
48
Intrinsic asthma and bacterial histamine release. ( 6177206 )
1982
49
Lung neuroendocrine structures. Topography, morphology, composition and relation with intrinsic asthma (non-immune). ( 6120685 )
1981
50
A trial of ketotifen in intrinsic asthma. ( 7028061 )
1981

Variations for Intrinsic Asthma

Expression for Intrinsic Asthma

Search GEO for disease gene expression data for Intrinsic Asthma.

Pathways for Intrinsic Asthma

Pathways related to Intrinsic Asthma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 CSF2RA FCER2 IL3 IL4 IL5 RNASE3
2
Show member pathways
13.32 CSF2RA FCER2 IL3 IL4 IL5
3
Show member pathways
12.97 CSF2RA IL3 IL4 IL5
4
Show member pathways
12.94 CSF2RA FCER2 IL3 IL4 IL5
5
Show member pathways
12.52 IL3 IL4 IL5 RNASE3
6 12.43 CSF2RA IL3 IL4 IL5
7
Show member pathways
12.27 IL3 IL4 IL5
8
Show member pathways
12.15 CSF2RA IL3 IL4 IL5
9
Show member pathways
11.82 CSF2RA IL3 IL5
10
Show member pathways
11.78 IL3 IL4 IL5
11 11.61 IL3 IL4 IL5
12 11.53 IL4 IL5
13 11.51 IL4 IL5
14 11.4 IL4 IL5
15
Show member pathways
11.38 IL3 IL4 IL5
16 11.25 FCER2 IL4
17 11.23 IL3 IL5
18 11.2 IL4 IL5
19 11.13 FCER2 IL4 IL5
20 11.04 IL4 IL5
21 11.02 IL4 IL5
22 11.01 CSF2RA FCER2 IL3 IL4 IL5
23 10.91 IL4 IL5
24 10.61 IL3 IL4 IL5

GO Terms for Intrinsic Asthma

Cellular components related to Intrinsic Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 CSF2RA FCER2 IL3 IL4 IL5 RNASE3

Biological processes related to Intrinsic Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.58 IL3 IL4 IL5
2 regulation of signaling receptor activity GO:0010469 9.5 IL3 IL4 IL5
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.37 IL3 IL5
4 MAPK cascade GO:0000165 9.33 CSF2RA IL3 IL5
5 positive regulation of B cell proliferation GO:0030890 9.26 IL4 IL5
6 peptidyl-tyrosine phosphorylation GO:0018108 9.13 CSF2RA IL3 IL5
7 cytokine-mediated signaling pathway GO:0019221 9.02 CSF2RA FCER2 IL3 IL4 IL5

Molecular functions related to Intrinsic Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 IL3 IL4 IL5
2 protein tyrosine kinase activity GO:0004713 9.33 CSF2RA IL3 IL5
3 growth factor activity GO:0008083 9.13 IL3 IL4 IL5
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.8 CSF2RA IL3 IL5

Sources for Intrinsic Asthma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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