MCID: INT040
MIFTS: 36

Intrinsic Asthma

Categories: Respiratory diseases

Aliases & Classifications for Intrinsic Asthma

MalaCards integrated aliases for Intrinsic Asthma:

Name: Intrinsic Asthma 12 54 15 70
Non-Atopic Asthma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9360
ICD9CM 34 493.1
SNOMED-CT 67 266397004
ICD10 32 J45
UMLS 70 C0155880

Summaries for Intrinsic Asthma

Disease Ontology : 12 A chronic asthma that is triggered by factors not attributable to allergies.

MalaCards based summary : Intrinsic Asthma, also known as non-atopic asthma, is related to exercise-induced bronchoconstriction and status asthmaticus. An important gene associated with Intrinsic Asthma is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Omalizumab and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include t cells, smooth muscle and skin.

Related Diseases for Intrinsic Asthma

Diseases related to Intrinsic Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 254)
# Related Disease Score Top Affiliating Genes
1 exercise-induced bronchoconstriction 32.0 RNASE3 IL13
2 status asthmaticus 30.0 RNASE3 IL5
3 ige responsiveness, atopic 30.0 RNASE3 IL5 IL4 IL13 IGHE
4 bronchitis 29.7 RNASE3 IL5 IL4 IL13 ADAM33
5 rhinitis 29.5 RNASE3 IL5 IL4 IL13 IGHE FCER2
6 proteasome-associated autoinflammatory syndrome 1 29.4 RNASE3 IL5 IL4 IL13 IGHE
7 food allergy 29.3 RNASE3 IL5 IL4 IL13 IGHE FCER2
8 autoimmune disease 29.3 IL5 IL4 IL13 CSF2
9 lung disease 29.2 RNASE3 IL5 IL4 IL13 CSF2
10 allergic asthma 29.0 RNASE3 IL5 IL4 IL3 IL13 IGHE
11 pollen allergy 29.0 RNASE3 IL5 IL3 IL13 IGHE GHITM
12 urticaria 28.7 RNASE3 IL5 IL4 IL3 IL13 IGHE
13 hypereosinophilic syndrome 28.3 RNASE3 IL5 IL4 IL3 IL13 IGHE
14 allergic rhinitis 28.2 RNASE3 IL5 IL4 IL13 IGHE FCER2
15 dermatitis 28.0 RNASE3 IL5 IL4 IL13 IGHE FCER2
16 dermatitis, atopic 28.0 RNASE3 IL5 IL4 IL13 IGHE FCER2
17 allergic disease 27.9 RNASE3 IL5 IL4 IL3 IL13 IGHE
18 asthma 27.6 RNASE3 IL5 IL4 IL3 IL13 IGHE
19 environmental induced asthma 11.1
20 aspirin-induced respiratory disease 11.1
21 cow milk allergy 10.3 IL5 IL4
22 b-cell growth factor 10.3 IL4 IL3
23 hypereosinophilic syndrome, idiopathic 10.3 IL5 IL3
24 persistent polyclonal b-cell lymphocytosis 10.3 IL4 FCER2
25 patulous eustachian tube 10.3 RNASE3 IL5
26 pemphigoid gestationis 10.3 RNASE3 IL5
27 cytokine deficiency 10.3 IL5 IL13
28 aztreonam allergy 10.3 IL5 IL13
29 cefaclor allergy 10.3 IL5 IL13
30 amoxicillin allergy 10.3 IL3 IGHE
31 cefuroxime allergy 10.3 IL5 IL13
32 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL5 IL13
33 ceftriaxone allergy 10.3 IL5 IL13
34 respiratory syncytial virus infectious disease 10.3 IL5 IL13
35 loeffler syndrome 10.3 IL5 IL13
36 orange allergy 10.3 IL5 IL13
37 neurodermatitis 10.2 IL4 IL13
38 ocular cicatricial pemphigoid 10.2 RNASE3 IL4
39 anisakiasis 10.2 RNASE3 IGHE
40 scleritis 10.2 IL5 IL4
41 idiopathic nephrotic syndrome 10.2 IL4 IGHE
42 wells syndrome 10.2 RNASE3 IL5
43 chronic eosinophilic pneumonia 10.2 RNASE3 IL5
44 cardiomyopathy, familial hypertrophic, 20 10.2 IL5 IL13
45 norwegian scabies 10.2 IL5 CD4
46 acute asthma 10.2 RNASE3 IL5 IL4
47 metal allergy 10.2 IL4 CD4
48 mononeuritis multiplex 10.2 IL5 CD4
49 endomyocardial fibrosis 10.2 RNASE3 IL5 IL4
50 blepharoconjunctivitis 10.2 IL4 CD4

Graphical network of the top 20 diseases related to Intrinsic Asthma:



Diseases related to Intrinsic Asthma

Symptoms & Phenotypes for Intrinsic Asthma

Drugs & Therapeutics for Intrinsic Asthma

Drugs for Intrinsic Asthma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational Phase 3 242138-07-4
2 Pharmaceutical Solutions Phase 3
3 Anti-Asthmatic Agents Phase 3
4 Anti-Allergic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A 16-week Treatment, Multicenter, Randomized, Double Blind, Placebo-controlled, Parallel-group Study to Assess the Effect of Omalizumab on the Expression of FcεRI Receptors of Blood Basophils and Dendritic Cells in Patients With Severe Persistent Non-atopic Asthma, Uncontrolled Despite Optimal Therapy Completed NCT01007149 Phase 3 omalizumab;Placebo
2 Study of the Patterns of Microvesicles in the Serum of Participants With Atopic and Non-atopic Asthma Completed NCT00700726
3 Genetic Study of Familial Forms of Non-atopic Asthma Terminated NCT02911220
4 A Prospective, Open Label, Single-center Study of the Long-term Prognosis of Moderate to Severe Bronchial Hyperresponsiveness (BHR) in Asthmatic Preschool Children. Withdrawn NCT01144910

Search NIH Clinical Center for Intrinsic Asthma

Genetic Tests for Intrinsic Asthma

Anatomical Context for Intrinsic Asthma

MalaCards organs/tissues related to Intrinsic Asthma:

40
T Cells, Smooth Muscle, Skin, Monocytes, Neutrophil, Whole Blood, Pituitary

Publications for Intrinsic Asthma

Articles related to Intrinsic Asthma:

(show top 50) (show all 553)
# Title Authors PMID Year
1
Cytokine production from peripheral whole blood in atopic and nonatopic asthmatics: relationship with blood and sputum eosinophilia and serum IgE levels. 54 61
11117270 2000
2
Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals. 61 54
11106200 2000
3
[Bronchial asthma: pathogenetic mechanisms and genetic aspects]. 54 61
9446157 1997
4
Co-stimulation of cultured peripheral blood mononuclear cells from intrinsic asthmatics with exogenous recombinant IL-6 produce high levels of IL-4-dependent IgE. 54 61
9311509 1997
5
Eosinophils and eosinophil-associated cytokines in allergic inflammation. 54 61
9130521 1997
6
Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics. 54 61
9120316 1997
7
Comparison of sputum and serum eosinophil cationic protein (ECP) levels in nonatopic asthma and chronic obstructive pulmonary disease. 61 54
9250255 1997
8
Inflammatory determinants of asthma severity: mediator and cellular changes in bronchoalveolar lavage fluid of patients with severe asthma. 54 61
8939174 1996
9
IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. 61 54
8912771 1996
10
Clinical application of eosinophilic cationic protein in asthma. 61 54
7797059 1995
11
Soluble CD23 (sCD23) serum levels and lymphocyte subpopulations in peripheral blood in rhinitis and extrinsic and intrinsic asthma. 54 61
7653734 1994
12
Corrigendum to "Decreased methylation profiles in the TNFA gene promoters in type 1 macrophages and in the IL17A and RORC gene promoters in Th17 lymphocytes have a causal association with non-atopic asthma caused by obesity: A hypothesis" [Med. Hypotheses 2020 (134) 109527]. 61
33254503 2020
13
Defining pediatric asthma: phenotypes to endotypes and beyond. 61
33173175 2020
14
Neutrophil infiltrates and eosinophil aggregates in chronic rhinosinusitis with nasal polyps and EGPA. 61
33094393 2020
15
Epigenome-wide association study of DNA methylation and adult asthma in the Agricultural Lung Health Study. 61
32381493 2020
16
How to apply the personalized medicine in obesity-associated asthma? 61
32506978 2020
17
Chronic oral corticosteroids use and persistent eosinophilia in severe asthmatics from the Belgian severe asthma registry. 61
32787967 2020
18
Novel airway smooth muscle-mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma. 61
32299856 2020
19
Inhalations with Brine Solution from the 'Wieliczka' Salt Mine Diminish Airway Hyperreactivity and Inflammation in a Murine Model of Non-Atopic Asthma. 61
32645931 2020
20
Association of RANTES gene polymorphisms with susceptibility to childhood asthma: A meta-analysis. 61
32702834 2020
21
Domestic Risk Factors for Atopic and non-Atopic Asthma in First Nations Children Living in Saskatchewan, Canada. 61
32349273 2020
22
Adiposity and asthma in adults: a bidirectional Mendelian randomisation analysis of The HUNT Study. 61
31611343 2020
23
Role of viruses in asthma. 61
31989228 2020
24
Aeroallergen sensitization in Lebanese asthmatic children: the results of a cohort national study. 61
31858416 2020
25
A classification of chronic rhinosinusitis with nasal polyps based on structured histopathology. 61
31408543 2020
26
Filling a hole in ozone research: The impacts of early life microbiome alterations on pulmonary responses to a non-atopic asthma trigger. 61
31960586 2020
27
Decreased methylation profiles in the TNFA gene promoters in type 1 macrophages and in the IL17A and RORC gene promoters in Th17 lymphocytes have a causal association with non-atopic asthma caused by obesity: A hypothesis. 61
31877441 2020
28
Endomorphin-2- and Neurotensin- Based Chimeric Peptide Attenuates Airway Inflammation in Mouse Model of Nonallergic Asthma. 61
31779093 2019
29
Beneficial Effects of Neurotensin in Murine Model of Hapten-Induced Asthma. 61
31614422 2019
30
Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity. 61
31357023 2019
31
Exhaled nitric oxide can't replace the methacholine challenge in suspected pediatric asthma. 61
31476569 2019
32
Environmental exposure to endotoxin and its health outcomes: A systematic review. 61
30831472 2019
33
Introduction of fish and other foods during infancy and risk of asthma in the All Babies In Southeast Sweden cohort study. 61
30617650 2019
34
DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma. 61
30791383 2019
35
African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children. 61
30548437 2019
36
Genetic variants in RORA are associated with asthma and allergy markers in an admixed population. 61
30539779 2019
37
Causal relationships between adiposity and childhood asthma: bi-directional Mendelian Randomization analysis. 61
30026589 2019
38
The Application of the Extended Poincaré Plot in the Analysis of Physiological Variabilities. 61
30837892 2019
39
Murine models of hapten-induced asthma. 61
30798944 2018
40
STAT6 variants and non-atopic asthma in Pakistani population. 61
30511616 2018
41
Sputum interleukin-25 correlates with asthma severity: a preliminary study. 61
30429702 2018
42
Biomarkers for differentiation of patients with asthma and chronic obstructive pulmonary disease. 61
29035604 2018
43
Autoimmune Responses in Severe Asthma. 61
30088364 2018
44
Association of increased risk of asthma with elevated arginase & interleukin-13 levels in serum & rs2781666 G/T genotype of arginase I. 61
30381539 2018
45
Risk factors associated with allergic sensitization and asthma phenotypes among poultry farm workers. 61
29574825 2018
46
The absence of serum IgE antibodies indicates non-type 2 disease in young asthmatics. 61
29377450 2018
47
Sulfite-induced protein radical formation in LPS aerosol-challenged mice: Implications for sulfite sensitivity in human lung disease. 61
29306790 2018
48
Relationship between total serum immunoglobulin E levels, fractional exhaled breath nitric oxide levels and absolute blood eosinophil counts in atopic and non-atopic asthma: a controlled comparative study. 61
29068321 2018
49
Modulating Interleukins and their Receptors Interactions with Small Chemicals Using In Silico Approach for Asthma. 61
30068279 2018
50
Serum Proteome Profiling to Identify Proteins Promoting Pathogenesis of Non-atopic Asthma. 61
30255743 2018

Variations for Intrinsic Asthma

Expression for Intrinsic Asthma

Search GEO for disease gene expression data for Intrinsic Asthma.

Pathways for Intrinsic Asthma

Pathways related to Intrinsic Asthma according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 RNASE3 IL5 IL4 IL3 IL13 IGHE
2
Show member pathways
13.66 IL5 IL4 IL3 IL13 CSF2 CD4
3
Show member pathways
13.55 IL5 IL4 IL3 IL13 FCER2 CSF2
4
Show member pathways
13.37 IL5 IL4 IL3 IL13 CD4 CCL24
5
Show member pathways
13.29 IL5 IL4 IL3 IL13 CSF2 CD4
6
Show member pathways
13.2 IL5 IL4 IL3 IL13 CSF2 CD4
7
Show member pathways
13.12 IL5 IL4 IL3 IL13 IGHE FCER2
8
Show member pathways
12.74 RNASE3 IL5 IL4 IL3 IL13 CD4
9 12.68 IL5 IL4 IL3 IL13
10
Show member pathways
12.48 IL5 IL4 CSF2 CD4
11
Show member pathways
12.47 IL5 IL4 IL13 CD4
12
Show member pathways
12.34 IL5 IL4 IL3 IL13 CSF2
13
Show member pathways
12.27 IL5 IL4 IL3 IL13 IGHE CSF2
14
Show member pathways
12.25 IL5 IL4 IL13 CSF2
15
Show member pathways
12.14 IL5 IL4 IL3 IL13
16
Show member pathways
12.01 IL5 IL3 CSF2
17 11.93 IL4 IL13 IGHE FCER2
18 11.75 IL5 IL4 IL13 CSF2
19 11.71 IL5 IL4 IL13 CD4
20
Show member pathways
11.68 IL5 IL4 IL3 CSF2
21 11.62 IL5 IL4 IL3 CSF2 CD4
22 11.56 IL5 IL4 IL13 CSF2
23 11.53 IL5 IL4 IGHE FCER2
24 11.47 IL5 IL3 CSF2
25 11.43 IL5 IL4 IL3 FCER2 CSF2 CD4
26 11.36 IL4 IL13 FCER2 CSF2
27 11.29 IL5 IL4 IL13 CD4
28 11.27 IL5 IL4 IL13
29 11.17 IL5 IL4 IL13
30 11.11 IL13 CD4
31 10.94 IL5 IL4 IL3 IL13 CSF2 CCL24
32 10.73 IL5 IL4 IL13
33 10.56 IL5 IL4 IL3 IL13 CSF2 CD4

GO Terms for Intrinsic Asthma

Cellular components related to Intrinsic Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 RNASE3 IL5 IL4 IL3 IL13 CSF2
2 external side of plasma membrane GO:0009897 9.46 IL13 IGHE FCER2 CD4
3 extracellular region GO:0005576 9.28 RNASE3 IL5 IL4 IL3 IL13 IGHE

Biological processes related to Intrinsic Asthma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.87 IL5 IL4 IL3 CSF2
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.61 IL5 IL3 CD4
3 microglial cell activation GO:0001774 9.56 IL4 IL13
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.56 IL4 IL3 IL13 CSF2
5 immune response GO:0006955 9.56 IL5 IL4 IL3 IL13 IGHE CSF2
6 innate immune response in mucosa GO:0002227 9.55 RNASE3 IL4
7 macrophage differentiation GO:0030225 9.54 CSF2 CD4
8 positive regulation of immunoglobulin production GO:0002639 9.52 IL5 IL13
9 myeloid dendritic cell differentiation GO:0043011 9.51 IL4 CSF2
10 positive regulation of B cell proliferation GO:0030890 9.5 IL5 IL4 IL13
11 dendritic cell differentiation GO:0097028 9.49 IL4 CSF2
12 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.48 CSF2 CD4
13 positive regulation of podosome assembly GO:0071803 9.46 IL5 CSF2
14 positive regulation of mast cell degranulation GO:0043306 9.4 IL4 IL13
15 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL4 IL13
16 macrophage activation GO:0042116 9.33 IL4 IL13 CSF2
17 cytokine-mediated signaling pathway GO:0019221 9.23 IL5 IL4 IL3 IL13 IGHE FCER2

Molecular functions related to Intrinsic Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 IL5 IL4 IL3 CSF2
2 cytokine receptor binding GO:0005126 9.16 IL4 IL13
3 cytokine activity GO:0005125 9.1 IL5 IL4 IL3 IL13 CSF2 CCL24

Sources for Intrinsic Asthma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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