MCID: INT051
MIFTS: 53

Intussusception

Categories: Gastrointestinal diseases

Aliases & Classifications for Intussusception

MalaCards integrated aliases for Intussusception:

Name: Intussusception 57 12 54 44 15 32
Invagination of Intestine or Colon 12
Intussusception of Intestine 12

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant


HPO:

31
intussusception:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:8446
OMIM® 57 147710
ICD9CM 34 560.0
MeSH 44 D007443
NCIt 50 C113484
SNOMED-CT 67 155772009
ICD10 32 K56.1
MedGen 41 C0021933
SNOMED-CT via HPO 68 263681008 35327006 49723003
UMLS 70 C0021933

Summaries for Intussusception

MalaCards based summary : Intussusception, also known as invagination of intestine or colon, is related to meckel diverticulum and lipomatosis, multiple. An important gene associated with Intussusception is STK11 (Serine/Threonine Kinase 11), and among its related pathways/superpathways are ERK Signaling and Activation of cAMP-Dependent PKA. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and small intestine, and related phenotypes are intussusception and homeostasis/metabolism

Wikipedia : 73 Intussusception is a medical condition in which a part of the intestine folds into the section... more...

More information from OMIM: 147710

Related Diseases for Intussusception

Diseases related to Intussusception via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 854)
# Related Disease Score Top Affiliating Genes
1 meckel diverticulum 31.6 KIT CRP CD34
2 lipomatosis, multiple 31.3 PECAM1 KIT CD34 ANO1
3 ileus 31.2 VIP IL6 CRP CFTR
4 intestinal obstruction 31.2 KIT IL6 CRP CFTR CD34 ANO1
5 intestinal perforation 30.8 VEGFA IL6 CRP
6 constipation 30.8 VIP KIT IL6 CRP ANO1
7 endometriosis 30.8 VEGFA MIR126 KDR IL6
8 spindle cell sarcoma 30.8 VEGFA KIT IL6 CD34
9 adenocarcinoma 30.6 VEGFA STK11 KIT KDR FLT1
10 exanthem 30.6 VEGFA KIT IL6 CRP
11 lymphangioma 30.5 VEGFA PECAM1 KDR CD34
12 active peptic ulcer disease 30.5 KIT CRP ANO1
13 diverticulitis 30.5 IL6 FGF2 CRP
14 typhoid fever 30.4 IL6 CRP CFTR
15 fibrous histiocytoma 30.4 PECAM1 KIT CD34
16 neurilemmoma 30.4 KIT CD34 ANO1
17 irritable bowel syndrome 30.3 VIP IL6 CRP
18 toxic shock syndrome 30.3 IL6 CRP CD40LG
19 neurofibroma 30.3 VEGFA KIT CD34
20 acquired immunodeficiency syndrome 30.3 PECAM1 IL6 CRP CD40LG CD34
21 sarcoma 30.3 VEGFA KIT KDR IL6 FGF2
22 gastrointestinal stromal tumor 30.3 VEGFA TEK KIT KDR CD34 ANO1
23 gastric leiomyoma 30.3 KIT ANO1
24 mantle cell lymphoma 30.2 VEGFA KIT IL6 CD40LG
25 obstructive jaundice 30.2 KIT IL6 CRP
26 kaposi sarcoma 30.2 VEGFA IL6 FGF2 CD34
27 arteriovenous malformation 30.1 VEGFA TEK IL6
28 colonic lymphangioma 30.1 PECAM1 CD34
29 pneumonia 30.0 IL6 CRP CFTR CD40LG
30 disease by infectious agent 30.0 MIR126 IL6 CRP CFTR
31 mesenchymal cell neoplasm 29.9 PECAM1 KIT CD34 ANO1
32 portal hypertension 29.9 VEGFA PECAM1 CFTR
33 bilirubin metabolic disorder 29.8 VEGFA KIT IL6 CRP CFTR
34 pulmonary edema 29.8 TEK CRP CFTR
35 hemangiopericytoma, malignant 29.8 PECAM1 KIT CD34
36 connective tissue benign neoplasm 29.8 PECAM1 KIT CD34
37 kaposiform hemangioendothelioma 29.7 PECAM1 KDR CD34
38 mucosal melanoma 29.7 VEGFA KIT KDR
39 cystitis 29.7 VEGFA KIT IL6 CRP
40 varicose veins 29.7 VEGFA KDR IL6
41 ischemia 29.7 VEGFA TEK KDR FLT1 FGF2
42 arteries, anomalies of 29.7 VEGFA MIR126 IL6 CRP
43 skin melanoma 29.7 VEGFA STK11 PECAM1 KIT KDR IL6
44 hypertensive encephalopathy 29.6 VEGFA PGF FLT1
45 respiratory failure 29.6 VEGFA MIR126 IL6 CRP CFTR
46 sickle cell anemia 29.5 PGF IL6 CRP CD40LG
47 severe combined immunodeficiency 29.5 VEGFA KIT IL6 CD34
48 polyarteritis nodosa 29.5 PECAM1 IL6 FGF2 CRP
49 kidney disease 29.4 VEGFA PECAM1 MIR126 IL6 FLT1 CRP
50 combined immunodeficiency 29.4 VEGFA KIT IL6 CD40LG CD34

Graphical network of the top 20 diseases related to Intussusception:



Diseases related to Intussusception

Symptoms & Phenotypes for Intussusception

Human phenotypes related to Intussusception:

31
# Description HPO Frequency HPO Source Accession
1 intussusception 31 HP:0002576

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
G I:
intussusception

Clinical features from OMIM®:

147710 (Updated 05-Apr-2021)

MGI Mouse Phenotypes related to Intussusception:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 ANO1 CD34 CD40LG CDH5 CFTR CRP
2 cardiovascular system MP:0005385 10.39 ANO1 CD40LG CDH5 CRP FGF2 FLT1
3 hematopoietic system MP:0005397 10.31 CD34 CD40LG CDH5 CFTR FGF2 FLT1
4 immune system MP:0005387 10.3 CD34 CD40LG CDH5 CFTR CRP FLT1
5 integument MP:0010771 10.17 ANO1 CD34 CD40LG CDH5 IL6 KDR
6 muscle MP:0005369 10.07 ANO1 FGF2 FLT1 IL6 KDR KIT
7 liver/biliary system MP:0005370 10.01 CDH5 CFTR IL6 KDR KIT PECAM1
8 normal MP:0002873 9.91 CDH5 CFTR FLT1 KDR KIT STK11
9 neoplasm MP:0002006 9.87 CD34 FGF2 IL6 KIT PGF STK11
10 reproductive system MP:0005389 9.85 CD40LG CDH5 CFTR FGF2 FLT1 IL6
11 respiratory system MP:0005388 9.65 ANO1 CFTR IL6 KDR KIT PECAM1
12 vision/eye MP:0005391 9.4 CDH5 CFTR FGF2 FLT1 IL6 KDR

Drugs & Therapeutics for Intussusception

Drugs for Intussusception (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2 Immunologic Factors Phase 4
3
Hydrocortisone acetate Approved, Vet_approved 50-03-3
4
Hydrocortisone Approved, Vet_approved 50-23-7 5754
5 Hemostatics
6 Antibiotics, Antitubercular
7 Anti-Bacterial Agents
8 Pharmaceutical Solutions
9 Anti-Inflammatory Agents
10 Hydrocortisone hemisuccinate
11 Hydrocortisone 17-butyrate 21-propionate
12 Cola

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Potential Mechanisms for Intussusception After Rotavirus Vaccine-Pilot Study Completed NCT02542462 Phase 4 Rotarix®,;Rotarix®, with other routine vaccines;RotaTeq®,;RotaTeq®, with other routine vaccines
2 Outcomes of Stapled Trans-Anal Rectal Resection (STARR) vs. Biofeedback in the Treatment of Outlet Obstruction Associated With Rectal Intussusception and Rectocele: A Multi-center Randomized Controlled Trial Completed NCT00556283 Phase 4
3 A Multi-center Study to Assess the Outcomes of Stapled Trans-Anal Rectal Resection (STARR) in the Treatment of Obstructed Defecation Syndrome (ODS) Completed NCT00256984 Phase 4
4 Posterior Compression - Distraction Reduction (CDR) Technique in the Treatment of Basilar Invagination Associated With Atlantoaxial Dislocation Unknown status NCT02463630 Phase 3
5 Does the Stapled Transanal Rectal Resection (STARR Procedure) Has an Effect on Anal Compliance ? Unknown status NCT02052063
6 Point-of-Care Ultrasonography for Intussusception: A Randomized Noninferiority Trial Unknown status NCT03360643
7 Obstructed Defecation Caused by Rectal Intussusception and Rectocele:STARR Versus Laparoscopic Ventral Rectopexy Unknown status NCT01899209
8 Posterior Compression Distraction Reduction Technique System in the Treatment of BI-AAD Unknown status NCT03070743
9 Post-Authorization Safety Study (PASS) of Post-Marketing Surveillance for Intussusception Following Rotarix™ Introduction Into the Instituto Mexicano Del Seguro Social (IMSS) in Mexico Completed NCT00595205
10 Morbidity and Functional Outcome of Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM in Obstructed Defecation Completed NCT00673400
11 Implementation of Hospital-based Active Surveillance Procedures for Vaccine Safety Monitoring at IMSS Hospitals With Pediatric Medical Care in Mexico Completed NCT00436358
12 Prospective, Hospital-based, Multicentre Study to Assess the Incidence of Intussusception in Children < 2 Years of Age in Singapore Completed NCT01177839
13 Observational Database Study on the Incidence of Intussusception in Children Aged < 12 Months in Japan Completed NCT01479491
14 Seasonal Variations and Different Treatment Protocols OF Intussusception In Children: Our Center Experience. Completed NCT04486300
15 Paediatric Surgery Across Sub-Saharan Africa: A Multi-Centre Prospective Cohort Study Completed NCT03185637
16 Special Drug Use Investigation for ROTARIX Completed NCT01636739
17 Laparoscopic Gastric Plication: 5 Years of Follow-up in Mexican Patients Completed NCT03210207
18 Correlation of Anal Acoustic Reflectometry Parameters With Degree of Rectal Intussusception and Prolapse Completed NCT02774798
19 STARR With Contour Transtar for Obstructed Defecation Syndrome: Long Term Results Completed NCT02971332
20 The Role of Indocyanine Green Angiography Fluorescence on Intestinal Resections in Pediatric Surgery. Completed NCT04020939 Indocyanine Green
21 Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception: A Randomized Controlled Trial Recruiting NCT02691858 Hydrocortisone;Saline
22 GOODBYE HARTMANN. AFTER 100 YEARS HARTMANN'S PROCEDURE IS GOING TO BE ABANDONED? Recruiting NCT04829032
23 Seasonal Variations and Different Treatment Protocols of Intussusception in Children: Our Centers Experiences Not yet recruiting NCT04454320
24 Augmented BLAdder NecK rEconstruction Trial for Improved Urinary Function After Radical Prostatectomy Terminated NCT04305379

Search NIH Clinical Center for Intussusception

Cochrane evidence based reviews: intussusception

Genetic Tests for Intussusception

Anatomical Context for Intussusception

MalaCards organs/tissues related to Intussusception:

40
Colon, Appendix, Small Intestine, Pancreas, Lung, Liver, Breast

Publications for Intussusception

Articles related to Intussusception:

(show top 50) (show all 8579)
# Title Authors PMID Year
1
A family with intussusception and malignant hyperthermia. 57 61
7139491 1982
2
STK11 status and intussusception risk in Peutz-Jeghers syndrome. 61 54
16882735 2006
3
Peutz-Jeghers syndrome. 54 61
9429144 1997
4
Colorectal intussusception due to adenocarcinoma presenting as acute bowel obstruction in an adult. 61
33717392 2021
5
Peutz-Jeghers syndrome. 61
33591027 2021
6
A case report of inverted Meckel's diverticulum. 61
33732404 2021
7
Ileocolic intussusception caused by mass-forming fibro-granulation from healed ulcer masquerading as small bowel lipoma. 61
33405177 2021
8
Association Between Bowel Obstruction or Intussusception and Endometriosis. 61
33359555 2021
9
Association of air temperature with pediatric intussusception in northeastern China: A 10-year retrospective study. 61
33191045 2021
10
Gastrointestinal dysfunction in movement disorders. 61
33538914 2021
11
Shortening and Plication of Entero-enterostomy for Intussusception in Roux-en-Y Gastric Bypass: Video Report. 61
33512701 2021
12
Intussusception and SARS-CoV-2 infection. 61
33589873 2021
13
Measuring complications of serious pediatric emergencies using ICD-10. 61
33374034 2021
14
Untwisting the complexity of midgut malrotation and volvulus ultrasound. 61
33398405 2021
15
Management and Outcome of Pediatric Patients With Transient Small Bowel-Small Bowel Intussusception. 61
29746364 2021
16
Simultaneous Double Intussusception in a Patient with Cystic Fibrosis. 61
33794222 2021
17
Retrograde intussusception causing small bowel obstruction in a 35 year old Female patient following a Roux en Y Bypass. Case report. 61
33639498 2021
18
Epidemiology of Hospitalized Intussusception Cases from Northern States in India. 61
33452646 2021
19
Caecal inversion in association with ileocolic intussusception in a dog. 61
32959368 2021
20
Intussusception caused by intestinal neoplasia in mature rainbow trout (Oncorhynchus mykiss, Walbaum 1792). 61
33690895 2021
21
Intestinal obstruction secondary to jejunal intussusception in an adult. 61
32988643 2021
22
Epidemiology of Intussusception Hospitalizations in Children Under 2 Years of Age Post Rotavirus Vaccine Introduction in Tamil Nadu and Puducherry, India. 61
33469897 2021
23
Laparoscopic Resection of an Acute Rectosigmoid Intussusception Due to a Giant Pedunculated Lipoma. 61
33717770 2021
24
Ileocolic intussusception due to intestinal lipoma in an adult patient. 61
33768881 2021
25
Ultrasonography-guided hydrostatic reduction of ileocolic intussusception in childhood: First-line option for management of primary and recurrent cases. 61
33750282 2021
26
Expert Commentary on Adult Intussusception. 61
33769325 2021
27
Ultrasound-guided hydrostatic reduction of ileo-colic intussusception in childhood: first-line management for both primary and recurrent cases. 61
33719864 2021
28
Intussusception Due to Intestinal Melanoma. 61
32088297 2021
29
Open transumbilical intussusception reduction in children: A prospective study. 61
32792163 2021
30
Colo-colic intussusception secondary to colon lipoma: A case report. 61
33721822 2021
31
Adult Intestinal Intussusception: Practical Issues and Concerns. 61
33769323 2021
32
Ileoileal intussusception treated by polypectomy with spiral enteroscopy in Peutz-Jeghers syndrome. 61
33682897 2021
33
COVID-19 presenting as intussusception in infants: A case report with literature review. 61
33520650 2021
34
A Hospital-Based Multi-Centric Study to Determine the Clinico-Epidemiological Profile of Intussusception in Children < 2 Years in Rajasthan, India. 61
33403615 2021
35
Childhood Intussusception after Introduction of Indigenous Rotavirus Vaccine: Hospital-Based Surveillance Study from Odisha, India. 61
33544368 2021
36
End to end intussusception anastomosis decreases the risk of anastomotic leakage after neoadjvant chemoradiation and McKeown oesophagectomy. 61
33662437 2021
37
Gastroesophageal intussusception and extreme esophageal dilatation secondary to bilateral laryngeal paralysis in a cat. 61
33559171 2021
38
Child with dengue haemorrhagic fever complicated by ileocaecal intussusception. 61
33727286 2021
39
Severe jejunitis masquerading as intussusception in a case of Henoch-Schönlein purpura. 61
33779105 2021
40
Ultrasound-guided hydrostatic enema reduction of intussusception and confirmation with single abdominal radiograph in children. 61
33782988 2021
41
A rare cause of neonatal intussusception. Considering it might reduce the mortality. A case report and a review of the literature. 61
33718578 2021
42
A case of intussusception caused by diffuse large B cell lymphoma in ileocecal region. 61
32921627 2021
43
Colocolic Intussusception Associated with Octangium sp. (Digenea: Microscaphidiidae) in a Green Sea Turtle Chelonia mydas. 61
33713491 2021
44
Intussusception due to Incarceration of Hard Stool With the Ileocecal Valve as the Leading Point: A Case Study. 61
32604126 2021
45
Management of intussusception in children: A systematic review. 61
33158508 2021
46
Abdominal imaging findings in patients with SARS-CoV-2 infection: a scoping review. 61
32926211 2021
47
A Rare and Severe Presentation of Henoch-Schönlein Purpura in an Adolescent With Crescentic Glomerulonephritis, Arrhythmia, Acute Gastrointestinal Bleed, and Neurological Complications. 61
33796429 2021
48
Peutz-Jeghers syndrome in a woman presenting as intussusception: A case report. 61
33486311 2021
49
Antegrade Jejunojejunal Intussusception: An Unusual Complication Following Feeding Jejunostomy. 61
33728200 2021
50
Ischemic colitis of the right colon mimicking intussusception: A case report. 61
33262047 2021

Variations for Intussusception

Expression for Intussusception

Search GEO for disease gene expression data for Intussusception.

Pathways for Intussusception

Pathways related to Intussusception according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 VEGFA TEK STK11 PGF KIT KDR
2
Show member pathways
13.53 TEK PGF KIT KDR IL6 FLT1
3
Show member pathways
13.52 VEGFA TEK PGF KIT KDR IL6
4
Show member pathways
13.39 TEK PGF KIT KDR IL6 FLT1
5
Show member pathways
13.3 TEK PGF KIT KDR IL6 FLT1
6
Show member pathways
13.27 TEK PGF KIT KDR IL6 FLT1
7
Show member pathways
13.23 VEGFA TEK PGF KIT KDR IL6
8
Show member pathways
13.04 PGF KIT KDR IL6 FLT1 FGF2
9
Show member pathways
13.02 STK11 PGF KIT KDR IL6 FLT1
10 12.82 VEGFA PGF KIT IL6 FGF2
11
Show member pathways
12.81 VEGFA TEK STK11 PGF KIT KDR
12
Show member pathways
12.67 PGF KDR IL6 FLT1 FGF2 CD40LG
13 12.67 VEGFA TEK PGF KIT KDR FLT1
14
Show member pathways
12.62 VEGFA TEK PGF KIT KDR FLT1
15
Show member pathways
12.37 VEGFA KDR FLT1 FGF2
16 12.36 VEGFA KDR FLT1 FGF2
17
Show member pathways
12.34 TEK PGF KIT KDR IL6 FLT1
18
Show member pathways
12.24 PGF KIT KDR IL6 FLT1 FGF2
19 12.12 PECAM1 CDH5 CD40LG CD34
20 12.12 TEK KIT KDR FLT1 FGF2
21 12.08 VEGFA PECAM1 KDR CDH5
22 12.03 VEGFA KDR IL6 FGF2 CFTR
23
Show member pathways
11.98 VEGFA KDR FLT1 CDH5
24 11.95 VEGFA TEK IL6 FLT1
25 11.85 VEGFA TEK IL6 FLT1
26
Show member pathways
11.8 VIP IL6 CRP
27
Show member pathways
11.78 KIT KDR FLT1
28 11.78 KIT IL6 FGF2 CDH5 CD34
29
Show member pathways
11.73 VEGFA PGF KDR FLT1 CDH5
30 11.72 KIT IL6 CD34
31
Show member pathways
11.64 VEGFA IL6 CD40LG
32 11.56 KIT KDR FGF2
33 11.53 PECAM1 IL6 CD40LG
34 11.52 VEGFA KDR FGF2
35 11.52 VEGFA KIT IL6 FGF2
36 11.49 VEGFA KDR FGF2
37 11.41 VEGFA KDR FLT1 FGF2
38 11.38 TEK PECAM1 KDR FLT1 FGF2 CDH5
39
Show member pathways
11.34 KIT KDR FLT1
40 11.33 VEGFA KDR FLT1
41 11.19 VEGFA FLT1 FGF2
42
Show member pathways
10.76 VEGFA PGF KDR FLT1
43 10.71 TEK PGF KIT KDR IL6 FLT1
44 10.4 VEGFA TEK KDR FLT1 FGF2

GO Terms for Intussusception

Cellular components related to Intussusception according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 VIP VEGFA TEK PGF KDR IL6
2 extracellular space GO:0005615 9.85 VEGFA PGF PECAM1 MIR126 KIT IL6
3 membrane raft GO:0045121 9.71 TEK PECAM1 KDR ANO1
4 receptor complex GO:0043235 9.67 TEK KIT KDR FLT1
5 cell-cell junction GO:0005911 9.62 TEK PECAM1 KIT CDH5
6 cell surface GO:0009986 9.5 VEGFA TEK KIT CFTR CDH5 CD40LG
7 integral component of plasma membrane GO:0005887 9.32 TEK PECAM1 KIT KIR2DL4 KDR FLT1

Biological processes related to Intussusception according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.31 VIP VEGFA TEK PGF PECAM1 KIT
2 multicellular organism development GO:0007275 10.21 VEGFA TEK PGF KIT KDR FLT1
3 negative regulation of apoptotic process GO:0043066 10.13 VIP VEGFA TEK KDR IL6 CD40LG
4 positive regulation of gene expression GO:0010628 10.09 VEGFA KIT IL6 FGF2 CRP CDH5
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.03 VEGFA TEK MIR126 KDR FGF2
6 positive regulation of protein kinase B signaling GO:0051897 10.01 VEGFA TEK MIR126 KIT FGF2
7 protein autophosphorylation GO:0046777 10 TEK STK11 KIT KDR FLT1
8 positive regulation of cell migration GO:0030335 9.99 VEGFA PECAM1 KIT KDR FLT1 CDH5
9 peptidyl-tyrosine phosphorylation GO:0018108 9.97 TEK KIT KDR FLT1
10 angiogenesis GO:0001525 9.97 VEGFA TEK PGF KDR FLT1 FGF2
11 positive regulation of cell proliferation GO:0008284 9.97 VIP VEGFA PGF KIT KDR IL6
12 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.96 TEK KIT KDR FLT1
13 positive regulation of kinase activity GO:0033674 9.92 TEK KIT KDR FLT1
14 positive regulation of endothelial cell migration GO:0010595 9.91 VEGFA TEK KDR FGF2
15 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.89 VEGFA PGF KDR FLT1
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 VEGFA KIT IL6
17 positive regulation of MAP kinase activity GO:0043406 9.88 VEGFA KIT FLT1 FGF2
18 positive regulation of protein phosphorylation GO:0001934 9.88 VEGFA TEK PGF PECAM1 KDR FGF2
19 hematopoietic progenitor cell differentiation GO:0002244 9.87 KIT KDR FLT1
20 positive regulation of cell division GO:0051781 9.85 VEGFA PGF FGF2
21 positive chemotaxis GO:0050918 9.85 VEGFA PGF FGF2
22 positive regulation of interleukin-10 production GO:0032733 9.85 IL6 CD40LG CD34
23 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.84 VEGFA KDR FLT1
24 positive regulation of blood vessel endothelial cell migration GO:0043536 9.84 VEGFA MIR126 KDR FGF2
25 sprouting angiogenesis GO:0002040 9.82 VEGFA TEK PGF
26 positive regulation of sprouting angiogenesis GO:1903672 9.82 VEGFA MIR126 FGF2
27 maintenance of permeability of blood-brain barrier GO:0035633 9.81 PECAM1 IL6 CDH5
28 positive regulation of focal adhesion assembly GO:0051894 9.81 VEGFA TEK KDR
29 cell migration involved in sprouting angiogenesis GO:0002042 9.8 VEGFA KDR FGF2
30 negative regulation of endothelial cell apoptotic process GO:2000352 9.78 TEK MIR126 KDR CDH5
31 positive regulation of phospholipase C activity GO:0010863 9.76 KIT FLT1 FGF2
32 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.76 VEGFA MIR126 KDR FGF2
33 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.73 TEK KIT FLT1 FGF2
34 positive regulation of endothelial cell proliferation GO:0001938 9.73 VIP VEGFA TEK PGF KDR FGF2
35 positive regulation of vasculogenesis GO:2001214 9.71 KDR CD34
36 positive regulation of positive chemotaxis GO:0050927 9.71 VEGFA KDR
37 regulation of vascular permeability GO:0043114 9.71 TEK CDH5
38 stem cell proliferation GO:0072089 9.7 FGF2 CD34
39 negative regulation of lipid storage GO:0010888 9.7 IL6 CRP
40 vascular wound healing GO:0061042 9.7 VEGFA KDR CD34
41 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.7 VEGFA TEK MIR126 KIT KDR FLT1
42 paracrine signaling GO:0038001 9.69 FGF2 CD34
43 positive regulation of mast cell chemotaxis GO:0060754 9.69 VEGFA PGF
44 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.69 VEGFA KDR
45 vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 9.68 VEGFA KDR
46 endothelium development GO:0003158 9.68 KDR CD34
47 positive regulation of epithelial tube formation GO:1905278 9.67 VEGFA FGF2
48 glomerular endothelium development GO:0072011 9.65 PECAM1 CD34
49 vascular endothelial growth factor signaling pathway GO:0038084 9.62 VEGFA PGF KDR FLT1
50 positive regulation of MAPK cascade GO:0043410 9.56 VEGFA TEK MIR126 KIT KDR IL6

Molecular functions related to Intussusception according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.88 TEK STK11 KIT KDR FLT1
2 cytokine activity GO:0005125 9.76 VEGFA IL6 FGF2 CD40LG
3 growth factor activity GO:0008083 9.62 VEGFA PGF IL6 FGF2
4 vascular endothelial growth factor receptor 2 binding GO:0043184 9.43 VEGFA CDH5
5 growth factor binding GO:0019838 9.43 TEK KDR FLT1
6 vascular endothelial growth factor-activated receptor activity GO:0005021 9.4 KDR FLT1
7 vascular endothelial growth factor receptor binding GO:0005172 9.37 VEGFA PGF
8 chemoattractant activity GO:0042056 9.33 VEGFA PGF FGF2
9 protein tyrosine kinase activity GO:0004713 9.26 TEK KIT KDR FLT1
10 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.92 TEK KIT KDR FLT1

Sources for Intussusception

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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