MCID: INT051
MIFTS: 52

Intussusception

Categories: Gastrointestinal diseases
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Aliases & Classifications for Intussusception

MalaCards integrated aliases for Intussusception:

Name: Intussusception 57 11 53 43 14 31
Invagination of Intestine or Colon 11
Intussusception of Intestine 11

Characteristics:


Inheritance:

Autosomal dominant 57

Classifications:



External Ids:

Disease Ontology 11 DOID:8446
OMIM® 57 147710
ICD9CM 34 560.0
MeSH 43 D007443
NCIt 49 C113484
SNOMED-CT 68 155772009
ICD10 31 K56.1
MedGen 40 C0021933
SNOMED-CT via HPO 69 35327006 49723003
UMLS 71 C0021933

Summaries for Intussusception

MalaCards based summary: Intussusception, also known as invagination of intestine or colon, is related to lipomatosis, multiple and meckel diverticulum. An important gene associated with Intussusception is STK11 (Serine/Threonine Kinase 11), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and appendix, and related phenotypes are intussusception and homeostasis/metabolism

More information from OMIM: 147710

Related Diseases for Intussusception

Diseases related to Intussusception via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1132)
# Related Disease Score Top Affiliating Genes
1 lipomatosis, multiple 31.6 PECAM1 KIT CD34 ANO1
2 meckel diverticulum 31.4 KIT CRP CD34 ALB
3 ileus 31.3 VIP IL6 CRP CFTR
4 appendicitis 31.2 IL6 CRP ALB
5 lipoma of colon 31.2 KIT CRP ANO1
6 intestinal obstruction 31.2 KIT IL6 CRP CFTR CD34 ANO1
7 aortic dissection 31.1 IL6 CRP ALB
8 henoch-schoenlein purpura 31.0 IL6 CRP ALB
9 diarrhea 31.0 IL6 CFTR CD40LG ALB
10 crohn's disease 30.9 MIR126 IL6 CRP ALB
11 endometriosis 30.8 VEGFA MIR126 KDR IL6 FLT1
12 perinatal necrotizing enterocolitis 30.8 IL6 CRP ALB
13 inflammatory myofibroblastic tumor 30.8 KIT CD34 ANO1
14 intestinal perforation 30.7 VEGFA IL6 CRP ALB
15 constipation 30.7 VIP KIT IL6 CRP CFTR ANO1
16 mesenteric lymphadenitis 30.6 IL6 CRP ALB
17 peptic ulcer disease 30.6 IL6 CRP ALB
18 pancreatitis 30.6 IL6 CRP CFTR ALB
19 lymphangioma 30.5 VEGFA PECAM1 KDR IL6 CD34
20 neurilemmoma 30.5 KIT CD34 ANO1
21 mesenchymal cell neoplasm 30.5 PECAM1 KIT CD34 ANO1
22 neurofibroma 30.5 VEGFA KIT CD34
23 active peptic ulcer disease 30.4 KIT CRP ANO1 ALB
24 exanthem 30.4 VEGFA KIT IL6 CRP ALB
25 diverticulitis 30.4 IL6 FGF2 CRP ALB
26 aspiration pneumonia 30.3 IL6 CRP ALB
27 deficiency anemia 30.3 VEGFA MIR126 KIT IL6 CRP CD34
28 gastric leiomyoma 30.3 KIT CD34 ANO1
29 gastric ulcer 30.3 VEGFA IL6 FGF2
30 cystic fibrosis 30.3 VIP VEGFA IL6 CRP CFTR ANO1
31 hydronephrosis 30.3 VEGFA IL6 CRP ALB
32 pyogenic granuloma 30.3 VEGFA TEK PECAM1 CD34
33 typhoid fever 30.2 IL6 CRP CFTR ALB
34 dysentery 30.2 IL6 CRP ALB
35 cholangitis 30.2 IL6 CRP CFTR ALB
36 irritable bowel syndrome 30.2 VIP IL6 CRP
37 coccidiosis 30.2 IL6 CRP CD40LG ALB
38 acquired immunodeficiency syndrome 30.2 PECAM1 IL6 CRP CD40LG CD34 ALB
39 tetanus 30.2 IL6 CRP CD40LG ALB
40 colonic lymphangioma 30.2 PECAM1 CD34
41 pain agnosia 30.1 IL6 CRP ALB
42 common cold 30.1 IL6 CRP CD40LG
43 myoma 30.1 KIT CD34 ANO1
44 ischemic colitis 30.1 IL6 CRP ALB
45 compartment syndrome 30.1 IL6 CRP ALB
46 disease by infectious agent 30.1 MIR126 IL6 CRP ALB
47 inguinal hernia 30.1 KIT IL6 CRP CD34 ALB
48 bronchopneumonia 30.0 IL6 CRP ALB
49 kaposi sarcoma 30.0 VEGFA PECAM1 KDR IL6 FGF2 CD34
50 schistosomiasis 30.0 VEGFA CRP CD40LG ALB

Graphical network of the top 20 diseases related to Intussusception:



Diseases related to Intussusception

Symptoms & Phenotypes for Intussusception

Human phenotypes related to Intussusception:

30
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intussusception 30 HP:0002576

Symptoms via clinical synopsis from OMIM®:

57 (Updated 24-Oct-2022)
G I:
intussusception

Clinical features from OMIM®:

147710 (Updated 24-Oct-2022)

MGI Mouse Phenotypes related to Intussusception:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.45 ALB ANO1 CD34 CD40LG CDH5 CFTR
2 cardiovascular system MP:0005385 10.34 ALB ANO1 CD40LG CDH5 CRP FGF2
3 cellular MP:0005384 10.3 ALB CD34 CD40LG CDH5 CFTR FGF2
4 muscle MP:0005369 10.26 ALB ANO1 FGF2 FLT1 IL6 KDR
5 immune system MP:0005387 10.25 ALB CD34 CD40LG CDH5 CFTR CRP
6 normal MP:0002873 10.24 ALB CDH5 CFTR FLT1 KDR KIT
7 liver/biliary system MP:0005370 10.16 ALB CDH5 CFTR IL6 KDR KIT
8 neoplasm MP:0002006 10.09 ALB CD34 FGF2 IL6 KIT STK11
9 digestive/alimentary MP:0005381 10.08 ALB ANO1 CFTR IL6 KIT PECAM1
10 respiratory system MP:0005388 10.07 ANO1 CFTR IL6 KDR KIT MIR126
11 reproductive system MP:0005389 10.06 CD40LG CDH5 CFTR FGF2 FLT1 IL6
12 vision/eye MP:0005391 10.03 CDH5 CFTR FGF2 FLT1 IL6 KDR
13 hematopoietic system MP:0005397 10 CD34 CD40LG CDH5 CFTR FGF2 FLT1
14 mortality/aging MP:0010768 9.83 ALB ANO1 CD40LG CDH5 CFTR FGF2
15 integument MP:0010771 9.4 ANO1 CD34 CD40LG CDH5 CFTR IL6

Drugs & Therapeutics for Intussusception

Drugs for Intussusception (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2 Immunologic Factors Phase 4
3
Hydrocortisone Approved, Vet_approved 50-23-7 3640 5754
4
Hydrocortisone succinate Approved 2203-97-6 3643
5
Hydrocortisone acetate Approved, Vet_approved 50-03-3
6 Hydrocortisone 17-butyrate 21-propionate
7 Anti-Inflammatory Agents
8 Hemostatics
9 Pharmaceutical Solutions
10 Antibiotics, Antitubercular
11 Anti-Bacterial Agents
12 Cola

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Outcomes of Stapled Trans-Anal Rectal Resection (STARR) vs. Biofeedback in the Treatment of Outlet Obstruction Associated With Rectal Intussusception and Rectocele: A Multi-center Randomized Controlled Trial Completed NCT00556283 Phase 4
2 Potential Mechanisms for Intussusception After Rotavirus Vaccine-Pilot Study Completed NCT02542462 Phase 4 Rotarix®,;Rotarix®, with other routine vaccines;RotaTeq®,;RotaTeq®, with other routine vaccines
3 A Multi-center Study to Assess the Outcomes of Stapled Trans-Anal Rectal Resection (STARR) in the Treatment of Obstructed Defecation Syndrome (ODS) Completed NCT00256984 Phase 4
4 Posterior Compression - Distraction Reduction (CDR) Technique in the Treatment of Basilar Invagination Associated With Atlantoaxial Dislocation Unknown status NCT02463630 Phase 3
5 Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception: A Randomized Controlled Trial Unknown status NCT02691858 Hydrocortisone;Saline
6 Seasonal Variations and Different Treatment Protocols of Intussusception in Children: Our Centers Experiences Unknown status NCT04454320
7 Obstructed Defecation Caused by Rectal Intussusception and Rectocele:STARR Versus Laparoscopic Ventral Rectopexy Unknown status NCT01899209
8 Does the Stapled Transanal Rectal Resection (STARR Procedure) Has an Effect on Anal Compliance ? Unknown status NCT02052063
9 Posterior Compression Distraction Reduction Technique System in the Treatment of BI-AAD Unknown status NCT03070743
10 Prospective, Hospital-based, Multicentre Study to Assess the Incidence of Intussusception in Children < 2 Years of Age in Singapore Completed NCT01177839
11 Seasonal Variations and Different Treatment Protocols OF Intussusception In Children: Our Center Experience. Completed NCT04486300
12 Observational Database Study on the Incidence of Intussusception in Children Aged < 12 Months in Japan Completed NCT01479491
13 Point-of-Care Ultrasonography for Intussusception: A Randomized Noninferiority Trial Completed NCT03360643
14 Post-Authorization Safety Study (PASS) of Post-Marketing Surveillance for Intussusception Following Rotarix™ Introduction Into the Instituto Mexicano Del Seguro Social (IMSS) in Mexico Completed NCT00595205
15 Correlation of Anal Acoustic Reflectometry Parameters With Degree of Rectal Intussusception and Prolapse Completed NCT02774798
16 Risk Factors for Recurrent Intussusception After Successful Reduction in Pediatric Patients in a Tertiary Care Hospital of Nepal: A Prospective-Study Completed NCT05259670
17 STARR With Contour Transtar for Obstructed Defecation Syndrome: Long Term Results Completed NCT02971332
18 Morbidity and Functional Outcome of Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM in Obstructed Defecation Completed NCT00673400
19 The Role of Indocyanine Green Angiography Fluorescence on Intestinal Resections in Pediatric Surgery. Completed NCT04020939 Indocyanine Green
20 Implementation of Hospital-based Active Surveillance Procedures for Vaccine Safety Monitoring at IMSS Hospitals With Pediatric Medical Care in Mexico Completed NCT00436358
21 Paediatric Surgery Across Sub-Saharan Africa: A Multi-Centre Prospective Cohort Study Completed NCT03185637
22 Comparison of Hernia Sac Ligation Versus Invagination in Lichtenstein Tension Free Mesh Hernioplasty. Does Type of Hernia Have a Role on Outcomes? Completed NCT05308251
23 GOODBYE HARTMANN. AFTER 100 YEARS HARTMANN'S PROCEDURE IS GOING TO BE ABANDONED? Recruiting NCT04829032

Search NIH Clinical Center for Intussusception

Cochrane evidence based reviews: intussusception

Genetic Tests for Intussusception

Anatomical Context for Intussusception

Organs/tissues related to Intussusception:

MalaCards : Colon, Small Intestine, Appendix, Pancreas, Lung, Lymph Node, Bone Marrow

Publications for Intussusception

Articles related to Intussusception:

(show top 50) (show all 9179)
# Title Authors PMID Year
1
A family with intussusception and malignant hyperthermia. 62 57
7139491 1982
2
STK11 status and intussusception risk in Peutz-Jeghers syndrome. 53 62
16882735 2006
3
Peutz-Jeghers syndrome. 53 62
9429144 1997
4
A feces-filled non-inverted ileal pseudodiverticulum presenting as a pedunculated polyp successfully treated by traction-assisted endoscopic submucosal dissection. 62
35898827 2023
5
Impact of polio vaccines (oral polio vaccine - OPV or inactivated polio vaccine - IPV) on rotavirus vaccine-associated intussusception. 62
35439100 2022
6
Ileocecal duplication in children: a single-center experience of 115 cases. 62
36094665 2022
7
Metastatic Giant Cell Tumor Causing Small Bowel Intussusception on 18 F-FDG PET/CT. 62
35777978 2022
8
Prediction of Outcomes of Ultrasound-Guided Saline Enema in the Treatment of Pediatric Intussusception: A Retrospective Case-Control Study. 62
35179255 2022
9
Factors associated with surgical treatment in pediatric intussusception. 62
35896760 2022
10
Colonoscopic reduction of a transanal prolapsed ileocolic intussusception. 62
35166980 2022
11
A Surprising Lead Point in an Ileocolic Intussusception. 62
36252058 2022
12
Neutrophil-to-Lymphocyte Ratio as a Predictor of the Need for Surgical Treatment in Children's Intussusception. 62
35913089 2022
13
Colorectal intussusception with rectal prolapse related to cecal lipoma in adult: A rare case report and review of the literature. 62
36268305 2022
14
Retrograde Jejunogastric Intussusception of Efferent Limb Post-Whipple Procedure. 62
36261781 2022
15
Laparoscopic left colectomy with complete mesocolic excision for splenic flexure tumour with intussusception-a video vignette. 62
36219513 2022
16
Early Discovery Of Small Bowel Adenocarcinoma In a Patient Admitted For 4 Acute Intestinal Intussusception. 62
36268363 2022
17
Intussusception of the cecum due to the acute appendicitis: A case report. 62
36257138 2022
18
A Technique to Reduce the Early Recurrence of Intussusception in Ultrasound-Guided Hydrostatic Reduction. 62
34952973 2022
19
Multilayer-intussusception without intestinal necrosis: A case report. 62
35437183 2022
20
The "Hands" teaching model in intussusception. 62
35490064 2022
21
Intussusception surgery caused by transverse-colon lipoma: A case report. 62
35581041 2022
22
Ultrasound-guided manual reduction of small-intestine intussusception: A case report. 62
35577647 2022
23
Sigmoid lipoma as an exceptional cause of intussusception and bowel obstruction in adults: A case report and review of literature. 62
36032208 2022
24
Ileocolonic Intussusception Due to Hematoma After Snare Polypectomy. 62
35545819 2022
25
Adult intussusception due to ileal polyp - A case report. 62
36096079 2022
26
Common Conditions II: Acute Appendicitis, Intussusception, and Gastrointestinal Bleeding. 62
36209746 2022
27
RYGB-Induced Gut Dysmotility and Retrograde Intussusception: an Unusual Phenomenon. A Narrative Literature Review. 62
35947330 2022
28
Incidental appendectomy in surgical treatment of ileocolic intussusception in children. Is it safe to perform? 62
36217786 2022
29
COVID-19-Related Intussusception: A Case Series and Review of the Literature. 62
35984331 2022
30
Acute abdomen following axial torsion of a Giant Meckel's diverticulum in a young male: A case report. 62
36099772 2022
31
Five New Cases of Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome (MMIHS), with One Case Showing a Novel Mutation. 62
34383618 2022
32
Acute abdominal pain due to sigmoid volvulus with persistent descending mesocolon: a case report. 62
36180925 2022
33
Efficacy, safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants. 62
35926726 2022
34
Huge gastric trichobezoar caused by involuntary nocturnal trichophagia and trichotillomania in a female adolescent. 62
36148756 2022
35
Acute care diagnostics in children for general radiologists - not alone in the hospital at night. 62
36261070 2022
36
Colonic lipoma of the hepatic flexure causing invagination in an adult. 62
36196125 2022
37
Delayed diagnosis of serious paediatric conditions in 13 regional emergency departments. 62
36180208 2022
38
Review of the indications, methods, and clinical utility of anorectal manometry and the rectal balloon expulsion test. 62
35220645 2022
39
Associations of Polyp Characteristics in Children and Adolescents Presenting with Less Than Five Colorectal Polyps: A Full Colonoscopy Is Still Required. 62
36052612 2022
40
Time trend in the surgical management of obstructed defecation syndrome: a multicenter experience on behalf of the Italian Society of Colorectal Surgery (SICCR). 62
36104607 2022
41
Colo-colonic intussusception with post-polypectomy electrocoagulation syndrome: A case report. 62
36157670 2022
42
A feeding jejunostomy causing an intussusception - case report and literature review. 62
36158250 2022
43
Intussusception of the bowel in a young woman: A case report. 62
36177073 2022
44
Intestinal intussusception due to Vanek's tumour: A rare cause of intestinal obstruction in adults. 62
36116721 2022
45
Significance of MCP-1 in predicting the short-term recurrence of primary intussusception in children: An observational study. 62
36197260 2022
46
Incidence of Intussusception in Bamako, Mali, Before and After the Introduction of Rotavirus Vaccine. 62
35713304 2022
47
Jejunojejunal intussusception of a sutured enterotomy site after takedown and primary repair of persistent enterocutaneous fistula: a case report. 62
36158243 2022
48
An infrequent cause of left-colon intussusception. 62
36113672 2022
49
Our treatment approaches in recurrent chronic intussusceptions. 62
36043927 2022
50
Efficacy of Abdominal Ultrasonography for Differentiation of Gastrointestinal Diseases in Calves. 62
36230230 2022

Variations for Intussusception

Expression for Intussusception

Search GEO for disease gene expression data for Intussusception.

Pathways for Intussusception

Pathways related to Intussusception according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 CD40LG CDH5 FGF2 FLT1 IL6 KDR
2 13.71 CDH5 CFTR FGF2 FLT1 IL6 KDR
3
Show member pathways
13.38 TEK KIT KDR IL6 FLT1 FGF2
4
Show member pathways
13.27 TEK KIT KDR IL6 FLT1 FGF2
5
Show member pathways
13.23 VEGFA TEK KIT KDR IL6 FLT1
6
Show member pathways
13.03 STK11 KIT KDR IL6 FLT1 FGF2
7
Show member pathways
12.81 VEGFA TEK STK11 KIT KDR IL6
8 12.8 VEGFA KIT KDR FLT1 FGF2 CDH5
9
Show member pathways
12.67 CD40LG FGF2 FLT1 IL6 KDR
10 12.61 FGF2 FLT1 IL6 KDR KIT TEK
11
Show member pathways
12.37 VEGFA KDR FLT1 FGF2
12
Show member pathways
12.36 TEK KIT KDR IL6 FLT1 FGF2
13
Show member pathways
12.29 CDH5 FLT1 KDR VEGFA
14 12.21 TEK KIT KDR FLT1
15
Show member pathways
12.17 VEGFA KDR FLT1 FGF2
16 12.08 TEK KIT KDR FLT1 FGF2
17 11.87 CDH5 FGF2 IL6 VEGFA
18 11.86 VEGFA KDR IL6 FGF2 CFTR ALB
19
Show member pathways
11.84 TEK KIT KDR FLT1
20 11.81 KIT IL6 FGF2 CDH5 CD34
21 11.8 VEGFA KDR FLT1
22
Show member pathways
11.76 KIT KDR FLT1
23 11.74 VEGFA PECAM1 IL6
24 11.73 KIT IL6 CD34
25 11.71 IL6 CRP CD40LG
26
Show member pathways
11.65 CD40LG IL6 VEGFA
27 11.64 VEGFA KDR FLT1 CDH5
28 11.6 VEGFA KDR FGF2
29 11.56 VEGFA TEK KDR IL6
30 11.55 KIT KDR FGF2
31 11.5 VEGFA KDR FGF2
32 11.48 VEGFA KIT IL6 FGF2
33 11.41 VEGFA KDR FLT1 FGF2
34 11.4 VEGFA PECAM1 KDR
35 11.38 TEK PECAM1 KDR FLT1 FGF2 CDH5
36
Show member pathways
11.33 KIT KDR FLT1
37 11.28 VEGFA PECAM1 KDR FLT1 CDH5
38 11.27 FLT1 KDR VEGFA
39 11.02 VEGFA FLT1 FGF2
40
Show member pathways
10.93 VEGFA KDR FLT1
41 10.9 FGF2 FLT1 KDR TEK
42 10.87 TEK KIT KDR IL6 FLT1 FGF2
43 10.44 VEGFA KDR
44 10.34 VEGFA KDR
45 9.83 TEK KIT KDR FLT1

GO Terms for Intussusception

Cellular components related to Intussusception according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005887 9.8 ANO1 CD34 CD40LG CFTR FLT1 KDR
2 plasma membrane GO:0005886 9.8 ANO1 CD34 CD40LG CFTR FLT1 KDR
3 cell surface GO:0009986 9.77 VEGFA TEK KIT KDR CFTR CDH5
4 anchoring junction GO:0070161 9.63 ZNF185 TEK PECAM1 KDR CDH5

Biological processes related to Intussusception according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.6 CD34 CD40LG FGF2 IL6 KIR2DL4 KIT
2 negative regulation of apoptotic process GO:0043066 10.41 VIP VEGFA TEK KDR IL6 CD40LG
3 positive regulation of cell population proliferation GO:0008284 10.4 VIP VEGFA KIT KDR IL6 FLT1
4 positive regulation of gene expression GO:0010628 10.36 VEGFA KIT IL6 FGF2 CRP CDH5
5 positive regulation of protein phosphorylation GO:0001934 10.32 VEGFA TEK PECAM1 KDR FGF2
6 angiogenesis GO:0001525 10.31 VEGFA TEK KDR FLT1 FGF2
7 protein autophosphorylation GO:0046777 10.3 TEK STK11 KIT KDR FLT1
8 positive regulation of cell migration GO:0030335 10.29 VEGFA PECAM1 KIT KDR FLT1 CDH5
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 10.28 TEK KIT KDR FLT1
10 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.23 VEGFA TEK MIR126 KDR FGF2
11 positive regulation of MAP kinase activity GO:0043406 10.19 FGF2 FLT1 KIT VEGFA
12 ovarian follicle development GO:0001541 10.16 VEGFA KIT KDR
13 positive regulation of kinase activity GO:0033674 10.16 FLT1 KDR KIT TEK
14 positive regulation of interleukin-10 production GO:0032733 10.15 IL6 CD40LG CD34
15 positive regulation of endothelial cell migration GO:0010595 10.14 FGF2 KDR TEK VEGFA
16 positive regulation of protein kinase B signaling GO:0051897 10.13 VEGFA TEK MIR126 FGF2
17 maintenance of blood-brain barrier GO:0035633 10.12 CDH5 IL6 PECAM1
18 cellular response to vascular endothelial growth factor stimulus GO:0035924 10.11 FLT1 KDR VEGFA
19 vascular endothelial growth factor receptor signaling pathway GO:0048010 10.1 VEGFA KDR FLT1
20 positive regulation of focal adhesion assembly GO:0051894 10.09 VEGFA TEK KDR
21 endothelial cell proliferation GO:0001935 10.09 CD34 FGF2 TEK
22 cell migration involved in sprouting angiogenesis GO:0002042 10.05 FGF2 KDR VEGFA
23 positive regulation of blood vessel endothelial cell migration GO:0043536 10.02 VEGFA MIR126 KDR FGF2
24 positive regulation of endothelial cell proliferation GO:0001938 10.02 VIP VEGFA TEK KDR FGF2
25 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 10.01 TEK KIT FLT1 FGF2
26 positive regulation of sprouting angiogenesis GO:1903672 10 VEGFA MIR126 FGF2
27 vascular endothelial growth factor signaling pathway GO:0038084 10 VEGFA KDR FLT1
28 positive regulation of MAPK cascade GO:0043410 10 FGF2 FLT1 IL6 KDR KIT MIR126
29 negative regulation of endothelial cell apoptotic process GO:2000352 9.98 TEK MIR126 KDR CDH5
30 vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 9.97 KDR VEGFA
31 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.97 KDR VEGFA
32 positive regulation of phospholipase C activity GO:0010863 9.97 KIT FLT1 FGF2
33 glomerular endothelium development GO:0072011 9.95 PECAM1 CD34
34 vascular wound healing GO:0061042 9.93 CD34 KDR VEGFA
35 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.91 FGF2 KDR MIR126 VEGFA
36 regulation of MAPK cascade GO:0043408 9.84 KIT KDR FLT1
37 positive regulation of epithelial tube formation GO:1905278 9.83 VEGFA FGF2
38 positive regulation of angiogenesis GO:0045766 9.83 VEGFA TEK MIR126 KDR FLT1 FGF2
39 multicellular organism development GO:0007275 9.65 TEK KIT KDR FLT1 CDH5
40 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.4 VEGFA TEK MIR126 KIT KDR FLT1

Molecular functions related to Intussusception according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.5 TEK KIT KDR FLT1
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.23 TEK KIT KDR FLT1

Sources for Intussusception

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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