Aliases & Classifications for Intussusception

MalaCards integrated aliases for Intussusception:

Name: Intussusception 57 12 29 55 44 15
Invagination of Intestine or Colon 12
Intussusception of Intestine 12

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
intussusception:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 147710
Disease Ontology 12 DOID:8446
ICD10 33 K56.1
ICD9CM 35 560.0
MeSH 44 D007443
NCIt 50 C113484
MedGen 42 C0021933
SNOMED-CT via HPO 69 263681008
UMLS 73 C0021933

Summaries for Intussusception

MalaCards based summary : Intussusception, also known as invagination of intestine or colon, is related to gastroduodenitis and acalculous cholecystitis. An important gene associated with Intussusception is STK11 (Serine/Threonine Kinase 11), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Overview of nanoparticle effects. The drugs Vaccines and Citric Acid have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and appendix, and related phenotypes are intussusception and cardiovascular system

Wikipedia : 76 Intussusception is a medical condition in which a part of the intestine folds into the section next to... more...

Description from OMIM: 147710

Related Diseases for Intussusception

Diseases related to Intussusception via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 418)
# Related Disease Score Top Affiliating Genes
1 gastroduodenitis 30.7 CD40LG CD79A
2 acalculous cholecystitis 30.5 CD40LG CRP
3 intestinal tuberculosis 30.3 CD79A CRP
4 typhoid fever 30.1 CFTR CRP IL6
5 purpura 29.9 CD40LG CD79A CRP
6 leptospirosis 29.7 CD40LG CRP IL6
7 cholangitis 29.7 CD40LG CFTR CRP IL6
8 bronchopneumonia 29.6 CD40LG CD79A
9 jejunoileitis 29.6 CD40LG CD79A
10 cryptosporidiosis 29.6 CD40LG CD79A
11 coccidiosis 29.5 CD40LG CD79A
12 acquired immunodeficiency syndrome 29.4 CD40LG CD79A IL6
13 vasculitis 29.2 CD40LG CD79A CRP
14 myeloma, multiple 28.6 CD40LG CD79A CRP IL6
15 systemic lupus erythematosus 27.7 CD40LG CD79A CRP ENG IL6
16 thoraco abdominal enteric duplication 11.0
17 cold agglutinin disease 10.8 CRP IL6
18 cryopyrin-associated periodic syndrome 10.8 CRP IL6
19 cardiogenic shock 10.8 CRP IL6
20 acute cholangitis 10.8 CRP IL6
21 neutrophilia, hereditary 10.8 CRP IL6
22 uremic pruritus 10.8 CRP IL6
23 spinal disease 10.8 CRP IL6
24 castleman disease 10.8 CRP IL6
25 mononeuritis multiplex 10.7 CD40LG CRP
26 japanese spotted fever 10.7 CD40LG CRP
27 angina pectoris 10.7 CRP IL6
28 viral pneumonia 10.7 CRP IL6
29 suppurative otitis media 10.7 CD40LG CRP
30 cecal disease 10.7 CRP IL6
31 epididymitis 10.7 CD40LG CRP
32 relapsing polychondritis 10.7 CRP IL6
33 subacute thyroiditis 10.7 CRP IL6
34 dressler's syndrome 10.7 CD40LG CRP
35 louse-borne relapsing fever 10.7 CRP IL6
36 multicentric castleman disease 10.7 CRP IL6
37 ischemic heart disease 10.7 CRP IL6
38 mesenteric lymphadenitis 10.6 CRP IL6
39 transient arthritis 10.6 CD40LG IL6
40 alexithymia 10.6 CRP IL6
41 intermittent explosive disorder 10.6 CRP IL6
42 intermediate coronary syndrome 10.6 CRP IL6
43 streptococcal meningitis 10.6 CD40LG CRP
44 hemorrhagic fever 10.5 CD40LG IL6
45 acute cystitis 10.5 CRP IL6
46 scrub typhus 10.5 CD40LG CRP
47 mite infestation 10.5 CD79A CFTR
48 systolic heart failure 10.5 CRP IL6
49 polyarteritis nodosa 10.4 CRP IL6
50 selective igg deficiency disease 10.4 CD40LG CD79A

Graphical network of the top 20 diseases related to Intussusception:



Diseases related to Intussusception

Symptoms & Phenotypes for Intussusception

Symptoms via clinical synopsis from OMIM:

57
GI:
intussusception


Clinical features from OMIM:

147710

Human phenotypes related to Intussusception:

32
# Description HPO Frequency HPO Source Accession
1 intussusception 32 HP:0002576

MGI Mouse Phenotypes related to Intussusception:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 AIF1 CD40LG CRP ENG EPB41L5 IL6
2 hematopoietic system MP:0005397 9.56 ENG EPB41L5 IL6 STK11 AIF1 CD40LG
3 homeostasis/metabolism MP:0005376 9.28 AIF1 CD40LG CD79A CFTR CRP ENG

Drugs & Therapeutics for Intussusception

Drugs for Intussusception (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
2
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
3 Pharmaceutical Solutions Phase 3
4 Citrate Nutraceutical Phase 3
5
Hydrocortisone Approved, Vet_approved Not Applicable 50-23-7 5754
6
Butyric Acid Experimental, Investigational Not Applicable 107-92-6 264
7 Hemostatics Not Applicable
8 Anti-Bacterial Agents
9 Antibiotics, Antitubercular
10 Anti-Inflammatory Agents Not Applicable
11 Cortisol succinate Not Applicable
12 Hydrocortisone 17-butyrate 21-propionate Not Applicable
13 Hydrocortisone acetate Not Applicable
14 Hydrocortisone-17-butyrate Not Applicable

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
2 Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS) Completed NCT00256984 Phase 4
3 Stapled Trans Anal Rectal Resection (STARR) for Outlet Obstruction: Functional and Morphological Outcome Completed NCT00521872 Phase 4
4 Coadministration of Measles-rubella and Rotavirus Vaccines Completed NCT01700621 Phase 4
5 Optimising Rotavirus Vaccine in Aboriginal Children Recruiting NCT02941107 Phase 4 Rotarix (RV1);Placebo
6 Potential Mechanisms for Intussusception After Rotavirus Vaccine-Pilot Study Active, not recruiting NCT02542462 Phase 4 Rotarix®,;Rotarix®, with other routine vaccines;RotaTeq®,;RotaTeq®, with other routine vaccines
7 A Phase III Clinical Trial to Evaluate the Protective Efficacy of Three Doses of Oral Rotavirus Vaccine (ORV) 116E Unknown status NCT01305109 Phase 3
8 Rotavirus Efficacy and Safety Trial (REST)(V260-006) Completed NCT00090233 Phase 3
9 Long-term Efficacy and Safety of Subjects Approximately 3 Years After Priming With 2 Doses of GSK Bio's HRV Vaccine. Completed NCT00420316 Phase 3
10 A Study to Test 2 Doses of GSK Biologicals' Oral Live Attenuated Human Rotavirus (HRV) Vaccine in Healthy Infants Completed NCT00197210 Phase 3
11 A Study of the Immunogenicity, Tolerability, and Safety of a New Formulation of RotaTeq™ in Infants (V260-035) Completed NCT01600092 Phase 3
12 A Study to Test 2 Doses of the HRV Vaccine in Healthy Infants. Completed NCT00140673 Phase 3
13 A Clinical Trial to Study the Effect and Safety of Rotavirus Vaccine Against Severe Rotavirus Gastroenteritis in Healthy Indian Infants Completed NCT02133690 Phase 3
14 Efficacy, Safety, and Immunogenicity of V260 in Healthy Chinese Infants (V260-024) Completed NCT02062385 Phase 3
15 Consistency Lots Vaccine Study (V260-009) Completed NCT00092456 Phase 3
16 Efficacy and Safety of a Pentavalent Rotavirus Vaccine (BRV-PV) Against Severe Rotavirus Gastroenteritis in Niger Active, not recruiting NCT02145000 Phase 3
17 Dose Escalation Study to Evaluate Oral Rotavirus Vaccine 116E Live Attenuated in Healthy Infants 8 to 20 Weeks Old Unknown status NCT00439660 Phase 1, Phase 2
18 Safety and Immunogenicity of Rotavirus Vaccine (RotaTeq(R)) in Infants With Short Bowel Syndrome Completed NCT00767364 Phase 1
19 Surgical Treatment of Obstructed Defecation Syndrome Unknown status NCT01899209 Not Applicable
20 Evaluation of Universal Rotavirus Vaccination Program Unknown status NCT01273077
21 Study to Assess the Incidence of Intussusception in Children < 2 Years of Age in Singapore Completed NCT01177839
22 Intussusception Surveillance After Rotarix Introduction in Mexico Completed NCT00595205
23 Study on the Incidence of Intussusception (IS) in Children Aged < 12 Months in Japan Completed NCT01479491
24 Implementing Hospital-based Active Surveillance Procedures for Vaccine Safety Monitoring at IMSS Hospitals in Mexico Completed NCT00436358
25 Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM Completed NCT00673400 Not Applicable
26 Children's Surgery in Sub-Saharan Africa Completed NCT03185637
27 Special Drug Use Investigation for ROTARIX® Completed NCT01636739
28 Drug Use Investigation for ROTARIX® Completed NCT01636193
29 Long Term Results of STARR With Contour Transtar Completed NCT02971332
30 Safety Study of GSK Biologicals' Rotavirus Vaccine (Rotarix®) Administered to Children Aged <1 Year in the United States Completed NCT00875641
31 Obstructed Defaecation: Proctography Versus Ultrasound in Symptomatic Patients Completed NCT02239302
32 Gastric Plication in Mexican Patients Completed NCT03210207
33 Point-of-Care Ultrasonography for Intussusception Recruiting NCT03360643 Not Applicable
34 Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception Recruiting NCT02691858 Not Applicable Hydrocortisone;Saline
35 Correlation of Anal Acoustic Reflectometry Parameters With Degree of Rectal Intussusception and Prolapse Recruiting NCT02774798
36 Does the Stapled Transanal Rectal Resection (STARR Procedure) Has an Effect on Anal Compliance ? Recruiting NCT02052063 Not Applicable
37 A Surveillance Study of Diseases Specified as Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Children in Africa Prior to Implementation of the RTS,S/AS01E Candidate Recruiting NCT02374450 Not Applicable
38 The Epidemiology and Etiology of Acute Gastroenteritis Among Estonian Children After Introduction of Rotavirus Vaccines Active, not recruiting NCT02662543

Search NIH Clinical Center for Intussusception

Cochrane evidence based reviews: intussusception

Genetic Tests for Intussusception

Genetic tests related to Intussusception:

# Genetic test Affiliating Genes
1 Intussusception 29

Anatomical Context for Intussusception

MalaCards organs/tissues related to Intussusception:

41
Colon, Small Intestine, Appendix, Pancreas, Testes, Lung, B Cells

Publications for Intussusception

Articles related to Intussusception:

(show top 50) (show all 1201)
# Title Authors Year
1
Jejunojejunal intussusception: an unusual case of postoperative intestinal obstruction. ( 29909685 )
2018
2
Intussusception of the rectum in children; a rare case report. ( 29910859 )
2018
3
The incidence of negative intraoperative findings after unsuccessful hydrostatic reduction of ileocolic intussusception in children: A retrospective analysis. ( 29866482 )
2018
4
Incidence and epidemiology of intussusception among children under 2a8^years of age in Chenzhou and Kaifeng, China, 2009-2013. ( 29439864 )
2018
5
Cecal duplication: A mimicker of intussusception: A case report and review. ( 29922463 )
2018
6
Intussusception. ( 29278567 )
2018
7
Mantle Cell Lymphoma with a Single Protruding Lesion as the Cause of Intussusception. ( 29434133 )
2018
8
Appendiceal intussusception. ( 29316118 )
2018
9
A rare case of primary small bowel de-differentiated liposarcoma causing intussusception: A case report. ( 29901613 )
2018
10
Rectal lipoma as a lead point for colo-colonic intussusception. ( 29904490 )
2018
11
Laparoscopic diagnosis of retrograde peristalsis and intussusception in Roux-en-Y limb after laparoscopic gastrectomy: A case report. ( 29871028 )
2018
12
Use of Ultrasound in the Diagnostic Work-Up of Adult Intussusception - A Multicenter Retrospective Analysis. ( 29975971 )
2018
13
Factors associated with ultrasound-guided water enema reduction for pediatric intussusception in resource-limited setting: potential predictive role of thrombocytosis and anemia. ( 29459045 )
2018
14
Adult multicentric burkitt lymphoma with bowel obstruction due to intussusception. ( 29755022 )
2018
15
Giant Duodenal Lipoma: a Rare Cause of Vomiting, Anorexia, Unintentional Weight Loss, and Duodenal Intussusception. ( 29797145 )
2018
16
Comparison Between Small and Large Bowel Intussusception in Children: The Experience of a Large Tertiary Care Pediatric Hospital. ( 29337838 )
2018
17
Intussusception After Bariatric Surgery. ( 29845569 )
2018
18
Sonographic Evaluation and Monitoring of Pneumoperitoneum After Air Enema Reduction for Intussusception. ( 29438126 )
2018
19
Contribution of the virtual colonoscopy in a case of intestinal intussusception. ( 29313697 )
2018
20
Peutz-Jeghers Syndrome Presenting as Colonic Intussusception: A Rare Entity. ( 29707083 )
2018
21
Core curriculum illustration: colonic intussusception due to pedunculated lipoma. ( 29860542 )
2018
22
Side-to-side bowel anastomosis mimicking intussusception in a 2-year-old child with Peutz-Jeghers syndrome. ( 29955242 )
2018
23
Small bowel intussusception due to malignant melanoma: primary lesion or metastases? A case report. ( 29923490 )
2018
24
Laparoscopic ventral rectopexy in patients with fecal incontinence associated with rectoanal intussusception: prospective evaluation of clinical, physiological and morphological changes. ( 29956002 )
2018
25
Fever as a Presenting Symptom in Children Evaluated for Ileocolic Intussusception: The Experience of a Large Tertiary Care Pediatric Hospital. ( 29337836 )
2018
26
Pediatric intussusception and early discharge after pneumatic reduction. ( 29947299 )
2018
27
Unusual Presentation of Duodenal Ulcer Presenting with Duodenal Intussusception. ( 29619400 )
2018
28
Ileocecal endometriosis as an infrequent cause of intussusception. ( 29278003 )
2018
29
A Case of Jejunal Intussusception caused by Burkitt Lymphoma in an Acquired Immunodeficiency Syndrome Patient. ( 29637755 )
2018
30
Gastroduodenal intussusception and pylorus obstruction induced by a c-KIT-negative gastric gastrointestinal stromal tumor: case report and review of the literature. ( 29346826 )
2018
31
Ileocecal intussusception extending to left colon due to endometriosis. ( 29364012 )
2018
32
Double simultaneous intussusception caused by Meckel's diverticulum and intestinal duplication in a child. ( 29968497 )
2018
33
Calcifying fibrous tumor of small bowel causing intussusception. ( 29981435 )
2018
34
Common bile duct intussusception during ERCP for stone removal. ( 29905195 )
2018
35
Ileocolic intussusception: Predicting the probability of success of ultrasound guided saline enema from clinical and sonographic data. ( 29150367 )
2018
36
Anterograde jejunojejunal intussusception through the distal anastomosis as complication after Roux-en-Y gastric bypass. ( 29879867 )
2018
37
A rare case of jejunogastric intussusception following gastric surgery. ( 28129607 )
2017
38
Gastric Intussusceptions in a Red Corn Snake <i>(Pantherophis guttatus)</i> Associated with Cryptosporidiosis. ( 29955428 )
2017
39
Sporadic Jejunal Lateral Spreading Tumor: A Rare Cause of Recurrent Jejunojejunal Intussusception. ( 28848802 )
2017
40
Incidentally Detected Small Intestine Intussusception Caused by Primary Small Intestine Carcinoma on (18)F-FDG PET/CT. ( 28878855 )
2017
41
The Malingering Intussusception. ( 29849354 )
2017
42
Hospitalization rates for intussusception in children aged 0-59A months from 2009 to 2014 in Italy. ( 28075671 )
2017
43
A case of small intestinal intussusception caused by anisakiasis diagnosed and treated by upper gastrointestinal endoscopy. ( 28781357 )
2017
44
Small Bowel Intussusception in a 16-Month-Old Child With Peutz-Jeghers Syndrome. ( 28929791 )
2017
45
Protein-losing Enteropathy Caused by Spontaneous Reduction of Intussusception with Meckel's Diverticulum. ( 28413865 )
2017
46
Triple site intussusceptions in Peutz-Jeghers syndrome. ( 28768368 )
2017
47
Transient Adult Jejunojejunal Intussusception: A Case of Conservative Management vs. Surgery. ( 29317946 )
2017
48
Perforated Meckel's Diverticulum causing Intussusception in a Neonate. ( 28920033 )
2017
49
Burkitt lymphoma as a lead point for jejunojejunal intussusception in a human immunodeficiency virus patient. ( 28523628 )
2017
50
Antegrade jejunojejunal intussusception inside a retrograde jejunogastric intussusception (double intussusception)-A rare case report. ( 28881334 )
2017

Variations for Intussusception

Expression for Intussusception

Search GEO for disease gene expression data for Intussusception.

Pathways for Intussusception

Pathways related to Intussusception according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.86 CD79A ENG IL6
2 10.23 CRP IL6

GO Terms for Intussusception

Biological processes related to Intussusception according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.46 AIF1 CD40LG CRP IL6
2 B cell proliferation GO:0042100 9.26 CD40LG CD79A
3 negative regulation of lipid storage GO:0010888 8.96 CRP IL6
4 positive regulation of T cell proliferation GO:0042102 8.8 AIF1 CD40LG IL6

Sources for Intussusception

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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