MCID: INT051
MIFTS: 50

Intussusception

Categories: Gastrointestinal diseases

Aliases & Classifications for Intussusception

MalaCards integrated aliases for Intussusception:

Name: Intussusception 57 12 29 55 44 15
Invagination of Intestine or Colon 12
Intussusception of Intestine 12

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
intussusception:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 147710
Disease Ontology 12 DOID:8446
ICD10 33 K56.1
ICD9CM 35 560.0
MeSH 44 D007443
NCIt 50 C113484
SNOMED-CT 68 35327006 49723003
MedGen 42 C0021933
SNOMED-CT via HPO 69 263681008
UMLS 73 C0021933

Summaries for Intussusception

MalaCards based summary : Intussusception, also known as invagination of intestine or colon, is related to mesenteric lymphadenitis and acute pancreatitis. An important gene associated with Intussusception is STK11 (Serine/Threonine Kinase 11), and among its related pathways/superpathways is Overview of nanoparticle effects. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and small intestine, and related phenotypes are intussusception and cardiovascular system

Wikipedia : 76 Intussusception is a medical condition in which a part of the intestine folds into the section next to... more...

Description from OMIM: 147710

Related Diseases for Intussusception

Diseases related to Intussusception via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 356)
# Related Disease Score Top Affiliating Genes
1 mesenteric lymphadenitis 30.2 IL6 CRP
2 acute pancreatitis 30.2 IL6 CRP CFTR
3 cholangitis 29.9 IL6 CRP CFTR
4 perinatal necrotizing enterocolitis 29.8 IL6 CRP
5 typhoid fever 29.7 IL6 CRP CFTR
6 polyarteritis nodosa 29.6 IL6 CRP
7 arteriovenous malformation 29.4 IL6 ENG
8 leptospirosis 29.2 CRP IL6
9 thoraco abdominal enteric duplication 11.1
10 peutz-jeghers syndrome 10.5
11 lymphoma 10.4
12 degos 'en cocarde' erythrokeratoderma 10.4
13 pelvic organ prolapse 10.3
14 meckel diverticulum 10.3
15 adenocarcinoma 10.3
16 lipomatosis, multiple 10.3
17 pleomorphic lipoma 10.3
18 melanoma 10.3
19 adenoma 10.3
20 lipoma of colon 10.2
21 gastrointestinal stromal tumor 10.2
22 intestinal obstruction 10.2
23 cold agglutinin disease 10.2 IL6 CRP
24 cryopyrin-associated periodic syndrome 10.2 IL6 CRP
25 acute cholangitis 10.2 IL6 CRP
26 uremic pruritus 10.2 IL6 CRP
27 neutrophilia, hereditary 10.2 IL6 CRP
28 spinal disease 10.2 IL6 CRP
29 viral pneumonia 10.2 IL6 CRP
30 subacute thyroiditis 10.2 IL6 CRP
31 central nervous system vasculitis 10.2 IL6 CRP
32 relapsing polychondritis 10.2 IL6 CRP
33 multicentric castleman disease 10.2 IL6 CRP
34 sarcoma 10.2
35 appendicitis 10.2
36 castleman disease 10.2 IL6 CRP
37 cecal disease 10.2 IL6 CRP
38 louse-borne relapsing fever 10.2 IL6 CRP
39 pyelitis 10.2 IL6 CRP
40 ischemic heart disease 10.2 IL6 CRP
41 hypersensitivity reaction type iii disease 10.2 IL6 CRP
42 mycoplasma pneumoniae pneumonia 10.2 IL6 CRP
43 endometriosis 10.2
44 viral meningitis 10.2 IL6 CRP
45 intermittent explosive disorder 10.2 IL6 CRP
46 intermediate coronary syndrome 10.2 IL6 CRP
47 hemorrhagic fever 10.2 IL6 CD40LG
48 systolic heart failure 10.2 IL6 CRP
49 acute cystitis 10.2 IL6 CRP
50 prediabetes syndrome 10.2 IL6 CRP

Graphical network of the top 20 diseases related to Intussusception:



Diseases related to Intussusception

Symptoms & Phenotypes for Intussusception

Symptoms via clinical synopsis from OMIM:

57
G I:
intussusception


Clinical features from OMIM:

147710

Human phenotypes related to Intussusception:

32
# Description HPO Frequency HPO Source Accession
1 intussusception 32 HP:0002576

MGI Mouse Phenotypes related to Intussusception:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 AIF1 CD40LG CRP ENG EPB41L5 IL6
2 hematopoietic system MP:0005397 9.86 AIF1 CAMP CD40LG CFTR ENG EPB41L5
3 homeostasis/metabolism MP:0005376 9.76 AIF1 CD40LG CFTR CRP ENG EPB41L5
4 immune system MP:0005387 9.5 AIF1 CAMP CD40LG CFTR CRP IL6
5 vision/eye MP:0005391 9.1 AIF1 CAMP CFTR EPB41L5 IL6 STK11

Drugs & Therapeutics for Intussusception

Drugs for Intussusception (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
2 Vaccines Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
3
Ethanol Approved Phase 3 64-17-5 702
4
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
5 Citrate Phase 3
6 Pharmaceutical Solutions Phase 3
7 Contraceptive Agents Phase 3
8
Hydrocortisone acetate Approved, Vet_approved Not Applicable 50-03-3
9
Hydrocortisone Approved, Vet_approved Not Applicable 50-23-7 5754
10
Pancrelipase Approved, Investigational Not Applicable 53608-75-6
11
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
12
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
13
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
14
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
15
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
16 Hydrocortisone 17-butyrate 21-propionate Not Applicable
17 Hydrocortisone-17-butyrate Not Applicable
18 Anti-Inflammatory Agents Not Applicable
19 Cortisol succinate Not Applicable
20 pancreatin Not Applicable
21 Hemostatics Not Applicable
22 Anti-Bacterial Agents
23 Antibiotics, Antitubercular
24 Antineoplastic Agents, Hormonal Not Applicable
25 Hormone Antagonists Not Applicable
26 Peripheral Nervous System Agents Not Applicable
27 Immunoglobulins, Intravenous Not Applicable
28 Neuroprotective Agents Not Applicable
29 Prednisolone acetate Not Applicable
30 Hormones Not Applicable
31 Antiemetics Not Applicable
32 Gastrointestinal Agents Not Applicable
33 glucocorticoids Not Applicable
34 Protective Agents Not Applicable
35 Antibodies Not Applicable
36 Immunoglobulins Not Applicable
37 Methylprednisolone acetate Not Applicable
38 Autonomic Agents Not Applicable
39 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
40 Aspartic Acid Not Applicable
41 N-Methylaspartate Not Applicable
42 alanine Not Applicable

Interventional clinical trials:

(show top 50) (show all 58)
# Name Status NCT ID Phase Drugs
1 Potential Mechanisms for Intussusception After Rotavirus Vaccine-Pilot Study Completed NCT02542462 Phase 4 Rotarix®,;Rotarix®, with other routine vaccines;RotaTeq®,;RotaTeq®, with other routine vaccines
2 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
3 Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS) Completed NCT00256984 Phase 4
4 Stapled Trans Anal Rectal Resection (STARR) for Outlet Obstruction: Functional and Morphological Outcome Completed NCT00521872 Phase 4
5 Coadministration of Measles-rubella and Rotavirus Vaccines Completed NCT01700621 Phase 4
6 Optimising Rotavirus Vaccine in Aboriginal Children Recruiting NCT02941107 Phase 4 Rotarix (RV1);Placebo
7 Posterior Compression Distraction Reduction (CDR)Technique in the Treatment of BI-AAD Unknown status NCT02463630 Phase 3
8 A Phase III Clinical Trial to Evaluate the Protective Efficacy of Three Doses of Oral Rotavirus Vaccine (ORV) 116E Unknown status NCT01305109 Phase 3
9 Rotavirus Efficacy and Safety Trial (REST)(V260-006) Completed NCT00090233 Phase 3
10 Long-term Efficacy and Safety of Subjects Approximately 3 Years After Priming With 2 Doses of GSK Bio's HRV Vaccine. Completed NCT00420316 Phase 3
11 A Study to Test 2 Doses of GSK Biologicals' Oral Live Attenuated Human Rotavirus (HRV) Vaccine in Healthy Infants Completed NCT00197210 Phase 3
12 A Study of the Immunogenicity, Tolerability, and Safety of a New Formulation of RotaTeq™ in Infants (V260-035) Completed NCT01600092 Phase 3
13 A Study to Test 2 Doses of the HRV Vaccine in Healthy Infants. Completed NCT00140673 Phase 3
14 Efficacy and Safety of a Pentavalent Rotavirus Vaccine (BRV-PV) Against Severe Rotavirus Gastroenteritis in Niger Active, not recruiting NCT02145000 Phase 3
15 A Clinical Trial to Study the Effect and Safety of Rotavirus Vaccine Against Severe Rotavirus Gastroenteritis in Healthy Indian Infants Completed NCT02133690 Phase 3
16 Efficacy, Safety, and Immunogenicity of V260 in Healthy Chinese Infants (V260-024) Completed NCT02062385 Phase 3
17 Phase III Study of Liquid Formulation of ROTAVIN Not yet recruiting NCT03703336 Phase 3
18 A Multicenter, Open-Label, Non-Comparative Study of the Safety and Contraceptive Efficacy of the Woman's Condom Completed NCT01223313 Phase 3
19 Consistency Lots Vaccine Study (V260-009) Completed NCT00092456 Phase 3
20 Ovarian Endometrioma Ablation Using Plasma Energy Versus Cystectomy Unknown status NCT01596985 Phase 2
21 Dose Escalation Study to Evaluate Oral Rotavirus Vaccine 116E Live Attenuated in Healthy Infants 8 to 20 Weeks Old Unknown status NCT00439660 Phase 1, Phase 2
22 Phase I Intratumoral Pbi-shRNA STMN1 LP in Advanced and/or Metastatic Cancer Completed NCT01505153 Phase 1
23 Safety and Immunogenicity of Rotavirus Vaccine (RotaTeq(R)) in Infants With Short Bowel Syndrome Completed NCT00767364 Phase 1
24 Duct-to-mucosa Versus Invagination for Pancreaticojejunostomy Unknown status NCT01695447 Not Applicable
25 Does the Stapled Transanal Rectal Resection (STARR Procedure) Has an Effect on Anal Compliance ? Unknown status NCT02052063 Not Applicable
26 Posterior Compression Distraction Reduction Technique System in the Treatment of BI-AAD Unknown status NCT03070743
27 Surgical Treatment of Obstructed Defecation Syndrome Unknown status NCT01899209 Not Applicable
28 Gingival Clefts and Orthodontic Movement Unknown status NCT01402323 Not Applicable
29 Evaluation of Universal Rotavirus Vaccination Program Unknown status NCT01273077
30 Point-of-Care Ultrasonography for Intussusception Recruiting NCT03360643 Not Applicable
31 Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception Recruiting NCT02691858 Not Applicable Hydrocortisone;Saline
32 Study to Assess the Incidence of Intussusception in Children < 2 Years of Age in Singapore Completed NCT01177839
33 Correlation of Anal Acoustic Reflectometry Parameters With Degree of Rectal Intussusception and Prolapse Recruiting NCT02774798
34 Intussusception Surveillance After Rotarix Introduction in Mexico Completed NCT00595205
35 Study on the Incidence of Intussusception (IS) in Children Aged < 12 Months in Japan Completed NCT01479491
36 Comparative Study Between Duct to Mucosa and Invagination Pancreaticojejunostomy After Pancreaticoduodenectomy: Completed NCT02142517 Not Applicable
37 Modified Duct-to-mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy Not yet recruiting NCT03600584 Not Applicable
38 Implementing Hospital-based Active Surveillance Procedures for Vaccine Safety Monitoring at IMSS Hospitals in Mexico Completed NCT00436358
39 Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM Completed NCT00673400 Not Applicable
40 Children's Surgery in Sub-Saharan Africa Completed NCT03185637
41 Evaluation and Intervention for the Effects of Osteogenesis Imperfecta Active, not recruiting NCT00001594
42 Special Drug Use Investigation for ROTARIX® Completed NCT01636739
43 Drug Use Investigation for ROTARIX® Completed NCT01636193
44 Safety Study of GSK Biologicals' Rotavirus Vaccine (Rotarix®) Administered to Children Aged <1 Year in the United States Completed NCT00875641
45 Performance and Safety Trial of an Innovative Female Condom (Wondaleaf®) Completed NCT02593214 Not Applicable
46 Long Term Results of STARR With Contour Transtar Completed NCT02971332
47 Laparoscopic Reinforcement Suture (LARS) of Duodenal Stump A Prospective Single Arm Phase II Study Recruiting NCT03085199 Not Applicable
48 Chen's U-Suture Technique for Pancreaticojejunostomy Following Pancreaticoduodenectomy Not yet recruiting NCT03767959 Not Applicable
49 Clinical Study on Strategy for Refractory Henoch-Schönlein Purpura Not yet recruiting NCT03647852 Not Applicable Methylprednisolone;IVIG
50 Abdomen CT and Open Appendicectomy:New Diagnostic and Surgical Procedures Completed NCT02574364 Not Applicable

Search NIH Clinical Center for Intussusception

Cochrane evidence based reviews: intussusception

Genetic Tests for Intussusception

Genetic tests related to Intussusception:

# Genetic test Affiliating Genes
1 Intussusception 29

Anatomical Context for Intussusception

MalaCards organs/tissues related to Intussusception:

41
Colon, Appendix, Small Intestine, Pancreas, Lung, B Cells, Myeloid

Publications for Intussusception

Articles related to Intussusception:

(show top 50) (show all 1880)
# Title Authors Year
1
Radiographic and Clinical Factors in Pediatric Patients With Surgical Small-bowel Intussusception. ( 30502244 )
2019
2
Jejunojejunal intussusception: an unusual case of postoperative intestinal obstruction. ( 29909685 )
2018
3
Intussusception of the rectum in children; a rare case report. ( 29910859 )
2018
4
The incidence of negative intraoperative findings after unsuccessful hydrostatic reduction of ileocolic intussusception in children: A retrospective analysis. ( 29866482 )
2018
5
Incidence and epidemiology of intussusception among children under 2a8^years of age in Chenzhou and Kaifeng, China, 2009-2013. ( 29439864 )
2018
6
Cecal duplication: A mimicker of intussusception: A case report and review. ( 29922463 )
2018
7
Intussusception. ( 29278567 )
2018
8
Mantle Cell Lymphoma with a Single Protruding Lesion as the Cause of Intussusception. ( 29434133 )
2018
9
Appendiceal intussusception. ( 29316118 )
2018
10
A rare case of primary small bowel de-differentiated liposarcoma causing intussusception: A case report. ( 29901613 )
2018
11
Rectal lipoma as a lead point for colo-colonic intussusception. ( 29904490 )
2018
12
Laparoscopic diagnosis of retrograde peristalsis and intussusception in Roux-en-Y limb after laparoscopic gastrectomy: A case report. ( 29871028 )
2018
13
Use of Ultrasound in the Diagnostic Work-Up of Adult Intussusception - A Multicenter Retrospective Analysis. ( 29975971 )
2018
14
Factors associated with ultrasound-guided water enema reduction for pediatric intussusception in resource-limited setting: potential predictive role of thrombocytosis and anemia. ( 29459045 )
2018
15
Adult multicentric burkitt lymphoma with bowel obstruction due to intussusception. ( 29755022 )
2018
16
Giant Duodenal Lipoma: a Rare Cause of Vomiting, Anorexia, Unintentional Weight Loss, and Duodenal Intussusception. ( 29797145 )
2018
17
Comparison Between Small and Large Bowel Intussusception in Children: The Experience of a Large Tertiary Care Pediatric Hospital. ( 29337838 )
2018
18
Intussusception After Bariatric Surgery. ( 29845569 )
2018
19
Sonographic Evaluation and Monitoring of Pneumoperitoneum After Air Enema Reduction for Intussusception. ( 29438126 )
2018
20
Contribution of the virtual colonoscopy in a case of intestinal intussusception. ( 29313697 )
2018
21
Peutz-Jeghers Syndrome Presenting as Colonic Intussusception: A Rare Entity. ( 29707083 )
2018
22
Core curriculum illustration: colonic intussusception due to pedunculated lipoma. ( 29860542 )
2018
23
Side-to-side bowel anastomosis mimicking intussusception in a 2-year-old child with Peutz-Jeghers syndrome. ( 29955242 )
2018
24
Small bowel intussusception due to malignant melanoma: primary lesion or metastases? A case report. ( 29923490 )
2018
25
Laparoscopic ventral rectopexy in patients with fecal incontinence associated with rectoanal intussusception: prospective evaluation of clinical, physiological and morphological changes. ( 29956002 )
2018
26
Fever as a Presenting Symptom in Children Evaluated for Ileocolic Intussusception: The Experience of a Large Tertiary Care Pediatric Hospital. ( 29337836 )
2018
27
Pediatric intussusception and early discharge after pneumatic reduction. ( 29947299 )
2018
28
Unusual Presentation of Duodenal Ulcer Presenting with Duodenal Intussusception. ( 29619400 )
2018
29
Ileocecal endometriosis as an infrequent cause of intussusception. ( 29278003 )
2018
30
A Case of Jejunal Intussusception caused by Burkitt Lymphoma in an Acquired Immunodeficiency Syndrome Patient. ( 29637755 )
2018
31
Gastroduodenal intussusception and pylorus obstruction induced by a c-KIT-negative gastric gastrointestinal stromal tumor: case report and review of the literature. ( 29346826 )
2018
32
Ileocecal intussusception extending to left colon due to endometriosis. ( 29364012 )
2018
33
Double simultaneous intussusception caused by Meckel's diverticulum and intestinal duplication in a child. ( 29968497 )
2018
34
Calcifying fibrous tumor of small bowel causing intussusception. ( 29981435 )
2018
35
Common bile duct intussusception during ERCP for stone removal. ( 29905195 )
2018
36
Retrograde gastroesophageal intussusception after peroral endoscopic myotomy in a patient with achalasia cardia: A case report. ( 29480864 )
2018
37
Prolapsed fundic gastric polyp causing gastroduodenal intussusception and acute pancreatitis. ( 29992001 )
2018
38
A case of cecocolonic intussusception after endoscopic submucosal dissection of a cecal adenoma. ( 29223381 )
2018
39
Non-Surgical Management of Colo-Colonic Intussusception in Patients with Hereditary Angioedema. ( 30301875 )
2018
40
Intussusception secondary to descending colon lipoma presenting with simultaneous acute appendicitis. ( 29992005 )
2018
41
Concurrent acute appendicitis and ileocolic intussusception in a 1-year-old child. ( 30023035 )
2018
42
Intussusception Mimicking Acute Appendicitis in an Adult. ( 30249346 )
2018
43
Appendiceal intussusception causing appendicitis. ( 28295983 )
2018
44
Atrial fibrillation, an epiphenomenon of acute Stanford type-A aortic dissection with suspected intimo-intimal intussusception. ( 30214765 )
2018
45
Testicular Choriocarcinoma Metastasizing to the Small Bowel Causing Intussusception: Case Report. ( 30368692 )
2018
46
Colocolonic intussusception in an adult cystic fibrosis patient. ( 30503033 )
2018
47
Isolated appendiceal endometriosis resulting in intussusception. ( 30275962 )
2018
48
Correction to: Ileocolic intussusception due to a cecal endometriosis: Case report and review of literature. ( 30143007 )
2018
49
Complete Appendiceal Intussusception Associated with Endometriosis. ( 29766445 )
2018
50
Adult Intussusception due to Gastrointestinal Stromal Tumor: A Rare Case Report, Comprehensive Literature Review, and Diagnostic Challenges in Low-Resource Countries. ( 30159192 )
2018

Variations for Intussusception

Expression for Intussusception

Search GEO for disease gene expression data for Intussusception.

Pathways for Intussusception

Pathways related to Intussusception according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.9 CRP IL6

GO Terms for Intussusception

Biological processes related to Intussusception according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.56 AIF1 CD40LG CRP IL6
2 defense response to Gram-positive bacterium GO:0050830 9.33 CAMP CRP IL6
3 acute-phase response GO:0006953 9.32 CRP IL6
4 negative regulation of lipid storage GO:0010888 8.96 CRP IL6
5 positive regulation of T cell proliferation GO:0042102 8.8 AIF1 CD40LG IL6

Sources for Intussusception

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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