MCID: INV001
MIFTS: 52

Invasive Aspergillosis

Categories: Infectious diseases, Bone diseases, Cardiovascular diseases, Respiratory diseases, Nephrological diseases, Eye diseases, Gastrointestinal diseases, Neuronal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Invasive Aspergillosis

MalaCards integrated aliases for Invasive Aspergillosis:

Name: Invasive Aspergillosis 12 15 73
Aspergillosis Invasive 55

Classifications:



External Ids:

Disease Ontology 12 DOID:0050073
UMLS 73 C0238013

Summaries for Invasive Aspergillosis

Disease Ontology : 12 An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.

MalaCards based summary : Invasive Aspergillosis, also known as aspergillosis invasive, is related to candidiasis and aspergillosis. An important gene associated with Invasive Aspergillosis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Caspofungin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and myeloid, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Related Diseases for Invasive Aspergillosis

Diseases in the Aspergillosis family:

Invasive Aspergillosis

Diseases related to Invasive Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 222)
# Related Disease Score Top Affiliating Genes
1 candidiasis 30.7 CD79A CLEC7A IFNG
2 aspergillosis 29.6 CD79A CLEC7A IFNG SFTPD TLR2 TLR4
3 colitis 29.3 CXCL8 IFNG TLR4 TLR9
4 pneumocystosis 28.9 CD79A CLEC7A FLNC SFTPD
5 pulmonary disease, chronic obstructive 28.3 CXCL10 CXCL8 SFTPD TLR2
6 rheumatoid arthritis 27.9 CD79A CXCL8 IFNG TLR2 TLR4
7 pneumonia 27.8 CXCL8 SFTPD TLR2 TLR4 TLR9
8 variola major 10.8 IFNG TLR4
9 coccidioidomycosis 10.8 CLEC7A TLR4
10 campylobacteriosis 10.7 IFNG TLR4
11 neuroschistosomiasis 10.7 CD79A IFNG
12 common wart 10.7 CLEC7A CXCL8
13 pouchitis 10.7 CXCL8 TLR4
14 pericardial tuberculosis 10.7 CABIN1 IFNG
15 sporotrichosis 10.7 CD79A IFNG
16 exudative glomerulonephritis 10.6 CD79A CXCL8
17 strongyloidiasis 10.6 CD79A IFNG
18 chronic graft versus host disease 10.6 CD79A IFNG
19 arteriolosclerosis 10.6 CABIN1 CD79A
20 cyclic neutropenia 10.6 CXCL8 IFNG
21 crohn's colitis 10.6 CXCL8 IFNG
22 erythema elevatum diutinum 10.6 CD79A CXCL8
23 meconium aspiration syndrome 10.6 CXCL8 IFNG
24 microscopic colitis 10.5 CD79A IFNG
25 trichomoniasis 10.5 CD79A CXCL8
26 urethritis 10.5 CD79A TLR6
27 ariboflavinosis 10.5 TLR4 TLR6
28 endometrial disease 10.5 CXCL8 TLR4
29 vulvovaginal candidiasis 10.5 CD79A CLEC7A IFNG
30 brucellosis 10.5 CXCL8 IFNG TLR4
31 cutaneous mycosis 10.4 CLEC7A FLNC
32 lymphadenitis 10.4 CXCL8 IFNG TLR4
33 autoinflammation, lipodystrophy, and dermatosis syndrome 10.4 CXCL8 IFNG TLR4
34 cervix disease 10.4 CD79A CXCL8
35 helicobacter pylori infection 10.4 CXCL8 IFNG TLR4
36 clonorchiasis 10.4 CD79A CXCL8 IFNG
37 periodontosis 10.4 CD79A CXCL8 TLR4
38 cardiac rupture 10.3 CXCL8 FLNC
39 pyelitis 10.3 CD79A TLR4
40 leukemia 10.3
41 hematopoietic stem cell transplantation 10.3
42 asymptomatic neurosyphilis 10.3 CD79A CXCL10
43 primary peritoneal carcinoma 10.2 CXCL10 CXCL8 IFNG
44 viral meningitis 10.2 CXCL10 CXCL8 IFNG
45 interstitial lung disease 10.2 CXCL8 IFNG SFTPD
46 severe acute respiratory syndrome 10.2 CXCL10 CXCL8 IFNG
47 leukemia, acute myeloid 10.2
48 myeloid leukemia 10.2
49 paranasal sinus disease 10.1 CD79A FLNC IFNG
50 prosthetic joint infection 10.1 TLR2 TLR4

Graphical network of the top 20 diseases related to Invasive Aspergillosis:



Diseases related to Invasive Aspergillosis

Symptoms & Phenotypes for Invasive Aspergillosis

GenomeRNAi Phenotypes related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CD79A CLEC7A CXCL8 FLNC TLR1 TLR9

MGI Mouse Phenotypes related to Invasive Aspergillosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 CABIN1 CD79A CLEC7A CXCL10 IFNG SFTPD
2 homeostasis/metabolism MP:0005376 9.81 CD79A CLEC7A CXCL10 FLNC IFNG SFTPD
3 immune system MP:0005387 9.7 SFTPD TLR1 TLR2 TLR4 TLR6 TLR9
4 respiratory system MP:0005388 9.1 CLEC7A FLNC IFNG SFTPD TLR2 TLR4

Drugs & Therapeutics for Invasive Aspergillosis

Drugs for Invasive Aspergillosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caspofungin Approved Phase 4,Phase 3,Phase 2,Not Applicable 179463-17-3, 162808-62-0 468682 2826718
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
3
Amphotericin B Approved, Investigational Phase 4,Phase 2,Phase 3 1397-89-3 14956 5280965
4
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 171228-49-2 147912
5
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
6
Anidulafungin Approved, Investigational Phase 4,Phase 3,Phase 2 166663-25-8 166548
7
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137234-62-9 71616
8
Itraconazole Approved, Investigational Phase 4,Phase 3 84625-61-6 55283
9
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
10
Mycophenolic acid Approved Phase 4 24280-93-1 446541
11
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
12 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
14 Echinocandins Phase 4,Phase 3,Phase 2
15 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
16 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
17 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
18 Liposomal amphotericin B Phase 4,Phase 2,Phase 3
19 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 glucocorticoids Phase 4,Phase 3
27
Hydroxyitraconazole Phase 4,Phase 3
28 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1
29 Immunosuppressive Agents Phase 4,Phase 1
30
Midazolam Approved, Illicit Phase 2, Phase 3,Phase 1 59467-70-8 4192
31
deoxycholic acid Approved Phase 3 83-44-3 222528
32
Aldesleukin Approved Phase 3 85898-30-2, 110942-02-4
33
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
34
Fluconazole Approved, Investigational Phase 3,Phase 1 86386-73-4 3365
35 Amphotericin B, deoxycholate drug combination Phase 3
36 Cholagogues and Choleretics Phase 3
37 Gastrointestinal Agents Phase 3,Phase 1
38 Analgesics Phase 3
39 Analgesics, Non-Narcotic Phase 3
40 Anti-HIV Agents Phase 3
41 Anti-Retroviral Agents Phase 3
42 Antiviral Agents Phase 3,Phase 2
43 Interleukin-2 Phase 3
44 Peripheral Nervous System Agents Phase 3
45 Antiemetics Phase 3
46 Anti-Inflammatory Agents Phase 3
47 Antineoplastic Agents, Hormonal Phase 3
48 Autonomic Agents Phase 3
49 BB 1101 Phase 3
50 Dexamethasone acetate Phase 3 1177-87-3

Interventional clinical trials:

(show top 50) (show all 89)
# Name Status NCT ID Phase Drugs
1 COMBISTRAT: AmBisome® in Combination With Caspofungin for the Treatment of Invasive Aspergillosis Completed NCT00334412 Phase 4 Ambisome;caspofungin
2 King's Invasive Aspergillosis Study II Not yet recruiting NCT02875743 Phase 4 Posaconazole
3 Post Marketing Study to Evaluate the Efficacy and Safety of Micafungin Treatment on Invasive Aspergillosis Terminated NCT02646774 Phase 4 Micafungin
4 Study to Test the Combination of Voriconazole and Anidulafungin in Patients Who Have, or Are Thought to Have, Invasive Aspergillosis and Who Are Unable to Take a Common Antifungal Therapy (Polyene) Terminated NCT00620074 Phase 4 voriconazole;anidulafungin
5 Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients Terminated NCT01282879 Phase 4 Itraconazole
6 A Study to Evaluate the Effectiveness of Voriconazole + Micafungin Versus Voriconazole Alone for Invasive Aspergillosis Withdrawn NCT00423163 Phase 4 micafungin;voriconazole
7 A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients Completed NCT00163722 Phase 3
8 Anidulafungin Plus Voriconazole Versus Voriconazole For The Treatment Of Invasive Aspergillosis Completed NCT00531479 Phase 3 voriconazole;anidulafungin;voriconazole
9 A Safety & Effectiveness Study of Intravenous Anidulafungin With AmBisome® for Treatment of Invasive Aspergillosis (IA). Completed NCT00037206 Phase 2, Phase 3 Anidulafungin, VER002
10 Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis Completed NCT00001646 Phase 3 Voriconazole;Amphotericin B
11 Study Safety/Efficacy of AmBisome Loading Dose Regimen Versus Standard AmBisome Regimen for Initial Treatment Completed NCT00158730 Phase 3 AmBisome
12 Isavuconazole (BAL8557) for Primary Treatment of Invasive Aspergillosis Completed NCT00412893 Phase 3 Isavuconazole;Voriconazole
13 Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis Completed NCT00263315 Phase 2, Phase 3 nebulised liposomal amphotericin B
14 Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis Completed NCT00003031 Phase 3 amphotericin B deoxycholate;voriconazole
15 Pharmacokinetic Profiles of Inhaled Lipid Complex Amphotericin B (Abelcet ®) Completed NCT00177684 Phase 3 Amphotericin B
16 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
17 Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101) Completed NCT02180165 Phase 3 Posaconazole;Voriconazole
18 Safety and Effectiveness of Granulocyte Transfusions in Resolving Infection in People With Neutropenia (The RING Study) Completed NCT00627393 Phase 3 Standard antimicrobial therapy;G-CSF/dexamethasone
19 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
20 Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi Completed NCT00634049 Phase 3 isavuconazole
21 A Study of the Safety and Efficacy of Posaconazole Versus Voriconazole for the Treatment of Invasive Aspergillosis (MK-5592-069) Recruiting NCT01782131 Phase 3 Posaconazole;Voriconazole
22 Caspofungin Acetate or Fluconazole in Preventing Invasive Fungal Infections in Patients With Acute Myeloid Leukemia Who Are Undergoing Chemotherapy Active, not recruiting NCT01307579 Phase 3 caspofungin acetate;fluconazole
23 A Study To Evaluate The Safety Of Voriconazole As Treatment Of Invasive Aspergillosis (Fungal Infection) And Other Rare Molds In Children Terminated NCT00836875 Phase 3 Voriconazole
24 To Determine Whether Galactomannan Test Will Help to Detect Fungal Infections Early and Hence Start Treatment Early Terminated NCT00361517 Phase 3 Amphotericin-B deoxycholate
25 Voriconazole And Anidulafungin Combination For Invasive Aspergillosis In Pediatric Subjects Withdrawn NCT01188759 Phase 3 Voriconazole;Anidulafungin;Voriconazole
26 Prophylaxis With Caspofungin in High-Risk Liver Transplantation Unknown status NCT00333645 Phase 2 Caspofungin
27 Caspofungin Maximum Tolerated Dose in Patients With Invasive Aspergillosis Completed NCT00404092 Phase 2 caspofungin
28 MK0991 in Combination With Standard Antifungal Agent(s) for the Treatment of Salvage Invasive Aspergillosis (0991-037) Completed NCT00076869 Phase 2 MK0991, caspofungin acetate;Comparator: amphotericin B;Comparator: lipid formulation of amphotericin B and/or azole
29 Study of FK463 for the Treatment of Invasive Aspergillosis Completed NCT00036166 Phase 2 FK463
30 Voriconazole With or Without Interferon Gamma in Treating Patients With Aspergillosis or Other Fungal Infections Completed NCT00059878 Phase 2 voriconazole
31 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
32 Prophylaxis of Fungal Invasive Infections in Leukemia Completed NCT00501098 Phase 2 Caspofungin
33 Nebulized Liposomal Amphotericin B Ambisome for Prophylaxis of Invasive Pulmonary Aspergillosis Completed NCT00391014 Phase 2 liposomal Amphotericine B
34 Nebulized Amphotericin B Lipid Complex in Invasive Pulmonary Aspergillosis in Paediatric Patients With Acute Leukaemia Completed NCT01615809 Phase 2 AMPHOTERICIN B
35 VL-2397 Compared to Standard First-Line Treatment for Invasive Aspergillosis (IA) in Adults Recruiting NCT03327727 Phase 2 Investigational Agent: VL-2397;Standard treatment: Voriconazole, Isavuconazole, or Liposomal amphotericin B
36 Study of Isavuconazole Prophylaxis in Adults With Acute Myeloid Leukemia/Myelodysplastic Syndrome (AML/MDS) and Neutropenia Recruiting NCT03019939 Phase 2 Isavuconazole
37 Micafungin Salvage Mono-therapy in Invasive Aspergillosis Terminated NCT00376337 Phase 2 Micafungin;Systemic antifungal therapy
38 Trial of Micafungin (FK463) in Combination With Liposomal Amphotericin B (AmBisome) for Aspergillosis Terminated NCT00047827 Phase 2 Micafungin;Liposomal Amphotericin B
39 Trial of Combination Antifungal Therapy (Vori+Mica vs. Vori+Placebo) in Invasive Aspergillosis Withdrawn NCT01207128 Phase 2 Voriconazole, micafungin
40 F901318 Multiple Ascending Dose Study Completed NCT02342574 Phase 1 F901318;Placebo
41 Evaluation of Immediate Release Tablet Completed NCT02808741 Phase 1 F901318 SDD;F901318 IR;F901318 IR Fasting;F901318 IR Fed
42 Multiple Ascending Oral Dose Study of F901318 in Healthy Subjects Completed NCT02737371 Phase 1 F901318 Dose level A oral;Placebo dose level A oral;F901318 Dose level B oral;Placebo dose level B oral;F901318 Dose level C oral;Placebo Dose level C oral
43 Study of Potential for Interaction of Fluconazole With F901318 Completed NCT02730442 Phase 1 F901318;Fluconazole
44 Evaluation of the Potential for Cytochrome P450 3A4 Inhibition by F901318 Using Oral Midazolam as a Probe Completed NCT02680808 Phase 1 Midazolam with F901318
45 Single Ascending Oral Dose Study of F901318 Completed NCT02394483 Phase 1 F901318 safety;F901318 tolerability;F901318 pharmacokinetics
46 F901318 Single Ascending Dose Study in Healthy Male Volunteers Completed NCT02142153 Phase 1 F901318;Placebo
47 Influence of Drug-drug Interactions on the Pharmacokinetics (PK) of Voriconazole Completed NCT01080651 Phase 1 Voriconazole
48 Assessment of Varying Oral Dosing Regimens for F901318 in Healthy Subjects Recruiting NCT03340597 Phase 1 F901318;Midazolam
49 Radiolabelled IV and Oral Metabolism Study of F901318 Not yet recruiting NCT02912026 Phase 1 IV F901318;Oral F901318
50 Drug/Drug Interactions With F901318 Withdrawn NCT03095547 Phase 1 cyclosporine A;Posaconazole;Pantoprazole;F901318;Tacrolimus

Search NIH Clinical Center for Invasive Aspergillosis

Genetic Tests for Invasive Aspergillosis

Anatomical Context for Invasive Aspergillosis

MalaCards organs/tissues related to Invasive Aspergillosis:

41
Lung, Testes, Myeloid, Liver, Bone, Kidney, Bone Marrow

Publications for Invasive Aspergillosis

Articles related to Invasive Aspergillosis:

(show top 50) (show all 692)
# Title Authors Year
1
The diagnosis and treatment of invasive aspergillosis in Dutch haematology units facing a rapidly increasing prevalence of azole-resistance. A nationwide survey and rationale for the DB-MSG 002 study protocol. ( 29687483 )
2018
2
Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy. ( 29750016 )
2018
3
Performance of serum (1,3)-A9-d-glucan screening for the diagnosis of invasive aspergillosis in neutropenic patients with haematological malignancies. ( 29693758 )
2018
4
Early-onset invasive aspergillosis and other fungal infections in patients treated with ibrutinib. ( 29437588 )
2018
5
Subacute invasive aspergillosis associated with sorafenib therapy for hepatocellular carcinoma. ( 29370392 )
2018
6
Predicting Invasive Aspergillosis in Hematology Patients by Combining Clinical and Genetic Risk Factors with Early Diagnostic Biomarkers. ( 29118175 )
2018
7
How we approach combination antifungal therapy for invasive aspergillosis and mucormycosis in transplant recipients. ( 29975240 )
2018
8
Chitinase Induction Prior to Caspofungin Treatment of Experimental Invasive Aspergillosis in Neutropenic Rats Does Not Enhance Survival. ( 29084744 )
2018
9
Cost-effectiveness analysis of interventions for prevention of invasive aspergillosis among leukemia patients during hospital construction activities. ( 29105850 )
2018
10
Invasive aspergillosis in patients following umbilical cord blood transplant. ( 29795425 )
2018
11
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis. ( 29980664 )
2018
12
Breakthrough invasive aspergillosis and diagnostic accuracy of serum galactomannan enzyme immune assay during acute myeloid leukemia induction chemotherapy with posaconazole prophylaxis. ( 29928481 )
2018
13
Galactomannan antigenemia as a biomarker for therapeutic response of invasive aspergillosis: implications for clinical trial design and patient care. ( 29897826 )
2018
14
Multiple small bowel perforations due to invasive aspergillosis in a patient with acute myeloid leukemia: case report and a systematic review of the literature. ( 29357049 )
2018
15
Diagnosis of Invasive Aspergillosis in Hematological Malignancy Patients: Performance of Cytokines, Asp LFD, and Aspergillus PCR in Same Day Blood and Bronchoalveolar Lavage Samples. ( 29972764 )
2018
16
The burden of Invasive Aspergillosis in patients with haematological malignancy: A meta-analysis and systematic review. ( 29727605 )
2018
17
Invasive Aspergillosis Mimicking Metastatic Lung Cancer. ( 29922593 )
2018
18
Galactomannan, a Surrogate Marker for Outcome in Invasive Aspergillosis: Finally Coming of Age. ( 29670608 )
2018
19
Invasive Aspergillosis with Pulmonary and Central Nervous System involvement during ibrutinib therapy for relapsed Chronic Lymphocytic Leukaemia, a case report. ( 29427802 )
2018
20
Epidemiology and Outcomes of Hospitalizations With Invasive Aspergillosis in the United States, 2009-2013. ( 29718296 )
2018
21
Characterisation of the cellular and proteomic response of Galleria mellonella larvae to the development of invasive aspergillosis. ( 29954319 )
2018
22
Outbreak of invasive aspergillosis in heart transplant recipients: The role of screening computed tomography scans in asymptomatic patients and universal antifungal prophylaxis. ( 29125713 )
2018
23
Massive haemoptysis secondary to mycotic pulmonary artery aneurysm in subacute invasive aspergillosis. ( 29674397 )
2018
24
Local retrospective analysis of galactomannan cut-off values in bronchoalveolar lavage fluids for diagnosis of invasive aspergillosis. ( 29846912 )
2018
25
Production of the Invasive Aspergillosis Biomarker Bis(methylthio)gliotoxin Within the Genus <i>Aspergillus: In Vitro and in Vivo</i> Metabolite Quantification and Genomic Analysis. ( 29946309 )
2018
26
Epidemiology of invasive aspergillosis and triazole-resistant Aspergillus fumigatus in patients with haematological malignancies: a single-centre retrospective cohort study. ( 29394399 )
2018
27
Improving the diagnosis of invasive aspergillosis by the detection of Aspergillus in broncho-alveolar lavage fluid: Comparison of non-culture-based assays. ( 29248586 )
2018
28
Use of Galactomannan Antigen and Aspergillus DNA Real-time Polymerase Chain Reaction as Routine Methods for Invasive Aspergillosis in Immunosuppressed Children in Greece. ( 29807668 )
2018
29
Urine Antigen Detection as an Aid to Diagnose Invasive Aspergillosis. ( 29684106 )
2018
30
Serum galactomannan antigen as a prognostic and diagnostic marker for invasive aspergillosis in heterogeneous medicine ICU patient population. ( 29684057 )
2018
31
Applying host disease status biomarkers to therapeutic response monitoring in invasive aspergillosis patients. ( 29370415 )
2018
32
Cost-Effectiveness Analysis of Isavuconazole vs. Voriconazole as First-Line Treatment for Invasive Aspergillosis. ( 27913989 )
2017
33
Utility of the serum galactomannan assay for the diagnosis of invasive aspergillosis in children with acute lymphoblastic leukemia. ( 27815226 )
2017
34
Invasive Aspergillosis of the Abdominal Aorta with Multiple Peripheral Embolic Lesions. ( 28567096 )
2017
35
Prospective Biomarker Screening for Diagnosis of Invasive Aspergillosis in High-Risk Pediatric Patients. ( 27795339 )
2017
36
Efficacy and safety of micafungin for the treatment of patients with proven or probable invasive aspergillosis: A non-comparative, multicenter, phase IV, open-label study. ( 29384927 )
2017
37
Invasive Aspergillosis with Disseminated Skin Involvement in a Patient with Acute Myeloid Leukemia: A Rare Case. ( 28626542 )
2017
38
Invasive aspergillosis in Refractory Angioimmunoblastic T cell lymphoma. ( 29129826 )
2017
39
Triazole resistance is still not emerging in A fumigatus isolates causing invasive aspergillosis in Brazilian patients. ( 28893772 )
2017
40
Caspofungin Increases Fungal Chitin and Eosinophil and I^I' T Cell-Dependent Pathology in Invasive Aspergillosis. ( 28566368 )
2017
41
Lateral Flow Assays for the Diagnosis of Invasive Aspergillosis: Current Status. ( 28680526 )
2017
42
The evolving landscape of new diagnostic tests for invasive aspergillosis in hematology patients: strengths and weaknesses. ( 28938246 )
2017
43
Molecular diagnosis of invasive aspergillosis and detection of azole resistance by a newly commercialized PCR kit. ( 28814586 )
2017
44
Challenges and Solution of Invasive Aspergillosis in Non-neutropenic Patients: A Review. ( 29273978 )
2017
45
Voriconazole-refractory invasive aspergillosis. ( 28835093 )
2017
46
Long-term follow up of invasive aspergillosis in allogeneic stem cell transplantation recipients and leukemia patients: Differences in risk factors and outcomes. ( 28689016 )
2017
47
Progressive Dispersion of Azole Resistance in Aspergillus fumigatus: Fatal Invasive Aspergillosis in a Patient with Acute Myeloid Leukemia Infected with an A. fumigatus Strain with a cyp51A TR46 Y121F M172I T289A Allele. ( 28743702 )
2017
48
Invasive aspergillosis in a patient with end stage renal disease. ( 28761803 )
2017
49
Drug-drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4. ( 28722255 )
2017
50
Fatal invasive aspergillosis caused by Aspergillus niger after bilateral lung transplantation. ( 28560131 )
2017

Variations for Invasive Aspergillosis

Expression for Invasive Aspergillosis

Search GEO for disease gene expression data for Invasive Aspergillosis.

Pathways for Invasive Aspergillosis

Pathways related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 CD79A CLEC7A CXCL10 CXCL8 IFNG TLR1
2
Show member pathways
13.31 CXCL10 CXCL8 TLR1 TLR2 TLR4 TLR6
3
Show member pathways
12.83 CXCL10 CXCL8 IFNG SFTPD TLR1 TLR2
4
Show member pathways
12.7 CXCL10 CXCL8 IFNG TLR2 TLR4 TLR9
5
Show member pathways
12.7 CD79A IFNG TLR1 TLR2 TLR4 TLR6
6
Show member pathways
12.61 CXCL10 CXCL8 IFNG TLR4
7
Show member pathways
12.61 TLR1 TLR2 TLR4 TLR6 TLR9
8
Show member pathways
12.45 TLR1 TLR2 TLR4 TLR6 TLR9
9
Show member pathways
12.39 TLR1 TLR2 TLR4 TLR6
10
Show member pathways
12.35 TLR1 TLR2 TLR4 TLR6 TLR9
11
Show member pathways
12.26 CXCL10 CXCL8 IFNG TLR2
12
Show member pathways
12.21 CXCL8 TLR1 TLR2 TLR4 TLR6 TLR9
13
Show member pathways
12.18 IFNG TLR1 TLR2 TLR4 TLR6 TLR9
14
Show member pathways
12.12 CXCL8 IFNG TLR4
15 12.1 IFNG TLR1 TLR2 TLR4 TLR6 TLR9
16 12.09 CLEC7A SFTPD TLR2 TLR4 TLR6
17 12.07 CABIN1 CD79A CXCL10 IFNG TLR1 TLR2
18
Show member pathways
11.99 TLR1 TLR2 TLR4 TLR6 TLR9
19 11.97 CXCL10 CXCL8 IFNG TLR4
20 11.95 CLEC7A IFNG TLR1 TLR2 TLR4 TLR6
21 11.85 CXCL8 IFNG TLR2 TLR4
22 11.81 CXCL8 IFNG TLR2 TLR4
23 11.78 CXCL8 FLNC IFNG TLR4
24
Show member pathways
11.69 CABIN1 CXCL8 IFNG
25 11.66 CLEC7A TLR1 TLR2 TLR4 TLR6 TLR9
26 11.54 CXCL8 TLR2 TLR4
27
Show member pathways
11.49 CXCL10 CXCL8 IFNG SFTPD TLR1 TLR2
28 11.47 IFNG TLR2 TLR4
29 11.46 CXCL8 IFNG TLR2 TLR4 TLR9
30 11.15 IFNG TLR1 TLR2

GO Terms for Invasive Aspergillosis

Cellular components related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytic vesicle membrane GO:0030670 9.33 TLR1 TLR2 TLR6
2 multivesicular body GO:0005771 9.26 CD79A SFTPD
3 membrane raft GO:0045121 9.26 CD79A TLR1 TLR2 TLR6
4 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.99 CABIN1 CD79A CXCL10 IFNG
2 response to lipopolysaccharide GO:0032496 9.97 CXCL10 CXCL8 TLR2 TLR4
3 immune response GO:0006955 9.95 CXCL10 CXCL8 IFNG TLR1 TLR2 TLR4
4 defense response to bacterium GO:0042742 9.92 SFTPD TLR1 TLR4 TLR6 TLR9
5 immune system process GO:0002376 9.92 CD79A CLEC7A SFTPD TLR1 TLR2 TLR4
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 TLR2 TLR4 TLR6 TLR9
7 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.9 TLR4 TLR6 TLR9
8 defense response GO:0006952 9.9 CXCL10 CXCL8 TLR1
9 cellular response to lipopolysaccharide GO:0071222 9.9 CXCL10 CXCL8 TLR4
10 positive regulation of inflammatory response GO:0050729 9.87 TLR2 TLR4 TLR9
11 inflammatory response GO:0006954 9.86 CLEC7A CXCL10 CXCL8 TLR1 TLR2 TLR4
12 positive regulation of interleukin-6 production GO:0032755 9.85 TLR2 TLR4 TLR9
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.84 TLR2 TLR4 TLR9
14 positive regulation of tumor necrosis factor production GO:0032760 9.82 TLR2 TLR4 TLR9
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IFNG TLR4 TLR6
16 positive regulation of interleukin-8 production GO:0032757 9.75 TLR2 TLR4 TLR9
17 positive regulation of interferon-beta production GO:0032728 9.74 TLR2 TLR4 TLR9
18 cellular response to amyloid-beta GO:1904646 9.73 TLR4 TLR6
19 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.73 TLR4 TLR6
20 negative regulation of interleukin-6 production GO:0032715 9.73 TLR4 TLR9
21 positive regulation of interleukin-10 production GO:0032733 9.73 TLR2 TLR4 TLR9
22 positive regulation of leukocyte chemotaxis GO:0002690 9.72 CXCL10 CXCL8
23 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.72 TLR4 TLR6
24 positive regulation of chemokine production GO:0032722 9.72 TLR2 TLR4 TLR9
25 positive regulation of macrophage activation GO:0043032 9.71 TLR4 TLR6
26 microglial cell activation GO:0001774 9.71 TLR2 TLR6
27 positive regulation of interleukin-8 secretion GO:2000484 9.71 TLR1 TLR2
28 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.71 TLR4 TLR6
29 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.71 TLR1 TLR4
30 cell activation GO:0001775 9.71 TLR1 TLR2 TLR6
31 cellular response to lipoteichoic acid GO:0071223 9.7 TLR2 TLR4
32 negative regulation of interleukin-17 production GO:0032700 9.7 IFNG TLR4
33 T-helper 1 type immune response GO:0042088 9.7 TLR4 TLR6
34 macrophage activation GO:0042116 9.7 TLR1 TLR4
35 interleukin-1 beta secretion GO:0050702 9.69 TLR4 TLR6
36 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.69 TLR2 TLR4 TLR9
37 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.68 TLR1 TLR6
38 positive regulation of interferon-beta biosynthetic process GO:0045359 9.68 TLR4 TLR9
39 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.68 TLR4 TLR6
40 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.68 TLR4 TLR6
41 response to molecule of bacterial origin GO:0002237 9.67 CXCL8 TLR2 TLR9
42 positive regulation of interleukin-12 production GO:0032735 9.67 IFNG TLR2 TLR4 TLR9
43 positive regulation of toll-like receptor signaling pathway GO:0034123 9.66 TLR2 TLR9
44 tumor necrosis factor production GO:0032640 9.66 TLR2 TLR9
45 cellular response to diacyl bacterial lipopeptide GO:0071726 9.65 TLR2 TLR6
46 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.65 TLR2 TLR6
47 positive regulation of interleukin-18 production GO:0032741 9.65 TLR2 TLR9
48 I-kappaB phosphorylation GO:0007252 9.65 TLR2 TLR4 TLR9
49 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.63 TLR1 TLR2
50 cellular response to triacyl bacterial lipopeptide GO:0071727 9.63 TLR1 TLR2

Molecular functions related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.62 TLR1 TLR2 TLR4 TLR6
2 transmembrane signaling receptor activity GO:0004888 9.55 CD79A TLR1 TLR4 TLR6 TLR9
3 CXCR chemokine receptor binding GO:0045236 9.46 CXCL10 CXCL8
4 signaling pattern recognition receptor activity GO:0008329 9.4 CLEC7A TLR2
5 lipopolysaccharide receptor activity GO:0001875 9.37 TLR2 TLR4
6 Toll-like receptor 2 binding GO:0035663 9.26 TLR1 TLR6
7 lipopolysaccharide binding GO:0001530 9.13 SFTPD TLR2 TLR4
8 lipopeptide binding GO:0071723 8.8 TLR1 TLR2 TLR6
9 protein binding GO:0005515 10.25 CABIN1 CD79A CLEC7A CXCL10 CXCL8 FLNC

Sources for Invasive Aspergillosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....