MCID: INV001
MIFTS: 52

Invasive Aspergillosis

Categories: Genetic diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Invasive Aspergillosis

MalaCards integrated aliases for Invasive Aspergillosis:

Name: Invasive Aspergillosis 12 15 74
Aspergillosis Invasive 56

Classifications:



External Ids:

Disease Ontology 12 DOID:0050073
UMLS 74 C0238013

Summaries for Invasive Aspergillosis

Disease Ontology : 12 An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.

MalaCards based summary : Invasive Aspergillosis, also known as aspergillosis invasive, is related to aspergillosis and candidiasis. An important gene associated with Invasive Aspergillosis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Caspofungin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and myeloid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Invasive Aspergillosis

Diseases in the Aspergillosis family:

Invasive Aspergillosis

Diseases related to Invasive Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 236)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 32.4 CLEC7A IFNG MBL2 SFTPD TLR2 TLR4
2 candidiasis 30.9 CLEC7A IFNG MBL2
3 cystic fibrosis 30.1 CXCL8 MBL2 SFTPD TLR4
4 colitis 29.9 CXCL8 IFNG TLR4
5 legionellosis 29.8 TLR2 TLR4 TLR5
6 legionnaires' disease 29.8 TLR4 TLR5 TLR6
7 ulcerative colitis 29.7 CXCL8 IFNG TLR4
8 pulmonary disease, chronic obstructive 29.3 CXCL10 CXCL8 SFTPD TLR2
9 pneumonia 29.3 CXCL8 MBL2 SFTPD TLR2 TLR4 TLR5
10 systemic lupus erythematosus 29.2 CXCL10 IFNG MBL2 TLR2 TLR4 TLR5
11 rheumatoid arthritis 29.0 CXCL8 IFNG TLR2 TLR4
12 lung disease 28.9 CXCL10 CXCL8 MBL2 SFTPD TLR2
13 malaria 28.1 CXCL10 CXCL8 IFNG IL12B TLR2 TLR4
14 leukemia 10.6
15 hematopoietic stem cell transplantation 10.4
16 variola major 10.4 IFNG TLR4
17 chronic granulomatous disease 10.3
18 campylobacteriosis 10.3 IFNG TLR4
19 leukemia, acute myeloid 10.3
20 myeloid leukemia 10.3
21 pericardial tuberculosis 10.3 CABIN1 IFNG
22 mucormycosis 10.3
23 coccidioidomycosis 10.3 CLEC7A MBL2 TLR4
24 common wart 10.2 CLEC7A CXCL8
25 trench fever 10.2 TLR2 TLR4
26 neutropenia 10.2
27 lymphocytic leukemia 10.2
28 urethritis 10.2 TLR1 TLR6
29 pouchitis 10.2 CXCL8 TLR4
30 scabies 10.2 CXCL8 MBL2
31 clonorchiasis 10.2 CXCL8 IFNG
32 acute leukemia 10.2
33 influenza 10.2
34 crohn's colitis 10.2 CXCL8 IFNG
35 superficial urinary bladder cancer 10.2 CXCL8 TLR4
36 meconium aspiration syndrome 10.2 CXCL8 IFNG
37 ocular toxoplasmosis 10.2 TLR1 TLR5
38 endometrial disease 10.1 CXCL8 TLR4
39 leukemia, acute lymphoblastic 10.1
40 lupus erythematosus 10.1
41 pyelitis 10.1 CXCL8 TLR4
42 typhoid fever 10.1 IFNG TLR4 TLR5
43 fungal meningitis 10.1 CXCL10 IFNG
44 tularemia 10.1 MBL2 TLR2
45 primary systemic mycosis 10.1 CLEC7A IFNG TLR2
46 fungal keratitis 10.1 CLEC7A TLR2 TLR4
47 periodontosis 10.1 CXCL8 TLR4
48 opportunistic mycosis 10.1 CLEC7A IFNG TLR2
49 myositis fibrosa 10.1 IFNG TLR2 TLR4
50 vulvovaginal candidiasis 10.1 CLEC7A MBL2 TLR2

Graphical network of the top 20 diseases related to Invasive Aspergillosis:



Diseases related to Invasive Aspergillosis

Symptoms & Phenotypes for Invasive Aspergillosis

GenomeRNAi Phenotypes related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

27 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.5 MBL2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.5 TLR4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.5 MBL2 TLR4 TLR6
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.5 TLR6
5 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.5 TLR4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.5 TLR4
7 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.5 TLR6
8 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.5 MBL2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.5 MBL2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.5 MBL2 TLR6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.5 MBL2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.5 TLR6

MGI Mouse Phenotypes related to Invasive Aspergillosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 CABIN1 CLEC7A CXCL10 IFNG IL12B MBL2
2 homeostasis/metabolism MP:0005376 9.81 CLEC7A CXCL10 IFNG IL12B MBL2 SFTPD
3 digestive/alimentary MP:0005381 9.8 CLEC7A IFNG IL12B TLR2 TLR4 TLR5
4 immune system MP:0005387 9.73 CABIN1 CLEC7A CXCL10 IFNG IL12B MBL2
5 respiratory system MP:0005388 9.17 CLEC7A IFNG IL12B SFTPD TLR2 TLR4

Drugs & Therapeutics for Invasive Aspergillosis

Drugs for Invasive Aspergillosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caspofungin Approved Phase 4,Phase 3,Phase 2,Not Applicable 162808-62-0, 179463-17-3 2826718 468682
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
3
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137234-62-9 71616
4
Amphotericin B Approved, Investigational Phase 4,Phase 2,Phase 3 1397-89-3 5280965 14956
5
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 171228-49-2 147912
6
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 477468 3081921
7
Anidulafungin Approved, Investigational Phase 4,Phase 3,Phase 2 166663-25-8 166548
8
Itraconazole Approved, Investigational Phase 4,Phase 3 84625-61-6 55283
9
Mycophenolic acid Approved Phase 4 24280-93-1 446541
10
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
20 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
21 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
22 Liposomal amphotericin B Phase 4,Phase 2,Phase 3
23 Pharmaceutical Solutions Phase 4,Phase 3
24 glucocorticoids Phase 4,Phase 3
25 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26
Hydroxyitraconazole Phase 4,Phase 3
27 Immunosuppressive Agents Phase 4,Phase 1
28
Midazolam Approved, Illicit Phase 2, Phase 3,Phase 1 59467-70-8 4192
29
Isavuconazole Approved, Investigational Phase 3,Phase 2 241479-67-4
30
deoxycholic acid Approved Phase 3 83-44-3 222528
31
Fluconazole Approved, Investigational Phase 3,Phase 1,Not Applicable 86386-73-4 3365
32
Aldesleukin Approved Phase 3 110942-02-4, 85898-30-2
33
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
34
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
35 Amphotericin B, deoxycholate drug combination Phase 3
36 Gastrointestinal Agents Phase 3,Phase 1
37 Cholagogues and Choleretics Phase 3
38 Cytochrome P-450 CYP2C19 Inhibitors Phase 3,Phase 1,Not Applicable
39 Anti-Retroviral Agents Phase 3
40 Interleukin-2 Phase 3
41 Anti-HIV Agents Phase 3
42 Peripheral Nervous System Agents Phase 3
43 Analgesics Phase 3
44 Analgesics, Non-Narcotic Phase 3
45 Antiviral Agents Phase 3,Phase 2
46 Anti-Inflammatory Agents Phase 3
47 HIV Protease Inhibitors Phase 3
48 Antineoplastic Agents, Hormonal Phase 3
49 Antiemetics Phase 3
50 Autonomic Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 96)
# Name Status NCT ID Phase Drugs
1 COMBISTRAT: AmBisome® in Combination With Caspofungin for the Treatment of Invasive Aspergillosis Completed NCT00334412 Phase 4 Ambisome;caspofungin
2 CYP2C19 Genotype-Specific Dosing Plus TDM on Reaching Therapeutic Voriconazole Blood Levels Recruiting NCT03731169 Phase 4 Standard of Care
3 King's Invasive Aspergillosis Study II Active, not recruiting NCT02875743 Phase 4 Posaconazole
4 Posaconazole Pharmacokinetics in Patients Receiving Chemotherapy or Stem Cell Transplants Not yet recruiting NCT03717623 Phase 4 Posaconazole pharmacokinetics
5 Post Marketing Study to Evaluate the Efficacy and Safety of Micafungin Treatment on Invasive Aspergillosis Terminated NCT02646774 Phase 4 Micafungin
6 Study to Test the Combination of Voriconazole and Anidulafungin in Patients Who Have, or Are Thought to Have, Invasive Aspergillosis and Who Are Unable to Take a Common Antifungal Therapy (Polyene) Terminated NCT00620074 Phase 4 voriconazole;anidulafungin
7 Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients Terminated NCT01282879 Phase 4 Itraconazole
8 A Study to Evaluate the Effectiveness of Voriconazole + Micafungin Versus Voriconazole Alone for Invasive Aspergillosis Withdrawn NCT00423163 Phase 4 micafungin;voriconazole
9 A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients Completed NCT00163722 Phase 3
10 Anidulafungin Plus Voriconazole Versus Voriconazole For The Treatment Of Invasive Aspergillosis Completed NCT00531479 Phase 3 voriconazole;anidulafungin;voriconazole
11 A Safety & Effectiveness Study of Intravenous Anidulafungin With AmBisome® for Treatment of Invasive Aspergillosis (IA). Completed NCT00037206 Phase 2, Phase 3 Anidulafungin, VER002
12 Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis Completed NCT00001646 Phase 3 Voriconazole;Amphotericin B
13 Study Safety/Efficacy of AmBisome Loading Dose Regimen Versus Standard AmBisome Regimen for Initial Treatment Completed NCT00158730 Phase 3 AmBisome
14 Isavuconazole (BAL8557) for Primary Treatment of Invasive Aspergillosis Completed NCT00412893 Phase 3 Isavuconazole;Voriconazole
15 Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis Completed NCT00263315 Phase 2, Phase 3 nebulised liposomal amphotericin B
16 To Determine Whether Galactomannan Test Will Help to Detect Fungal Infections Early and Hence Start Treatment Early Completed NCT00361517 Phase 3 Amphotericin-B deoxycholate
17 Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis Completed NCT00003031 Phase 3 amphotericin B deoxycholate;voriconazole
18 Pharmacokinetic Profiles of Inhaled Lipid Complex Amphotericin B (Abelcet ®) Completed NCT00177684 Phase 3 Amphotericin B
19 Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia Completed NCT01307579 Phase 3 Caspofungin Acetate;Fluconazole
20 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
21 Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101) Completed NCT02180165 Phase 3 Posaconazole;Voriconazole
22 Safety and Effectiveness of Granulocyte Transfusions in Resolving Infection in People With Neutropenia (The RING Study) Completed NCT00627393 Phase 3 Standard antimicrobial therapy;G-CSF/dexamethasone
23 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
24 Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi Completed NCT00634049 Phase 3 isavuconazole
25 A Study of the Safety and Efficacy of Posaconazole Versus Voriconazole for the Treatment of Invasive Aspergillosis (MK-5592-069) Recruiting NCT01782131 Phase 3 Posaconazole;Voriconazole
26 A Study To Evaluate The Safety Of Voriconazole As Treatment Of Invasive Aspergillosis (Fungal Infection) And Other Rare Molds In Children Terminated NCT00836875 Phase 3 Voriconazole
27 Voriconazole And Anidulafungin Combination For Invasive Aspergillosis In Pediatric Subjects Withdrawn NCT01188759 Phase 3 Voriconazole;Anidulafungin;Voriconazole
28 Prophylaxis With Caspofungin in High-Risk Liver Transplantation Unknown status NCT00333645 Phase 2 Caspofungin
29 Caspofungin Maximum Tolerated Dose in Patients With Invasive Aspergillosis Completed NCT00404092 Phase 2 caspofungin
30 MK0991 in Combination With Standard Antifungal Agent(s) for the Treatment of Salvage Invasive Aspergillosis (0991-037) Completed NCT00076869 Phase 2 MK0991, caspofungin acetate;Comparator: amphotericin B;Comparator: lipid formulation of amphotericin B and/or azole
31 Study of FK463 for the Treatment of Invasive Aspergillosis Completed NCT00036166 Phase 2 FK463
32 Voriconazole With or Without Interferon Gamma in Treating Patients With Aspergillosis or Other Fungal Infections Completed NCT00059878 Phase 2 voriconazole
33 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
34 Prophylaxis of Fungal Invasive Infections in Leukemia Completed NCT00501098 Phase 2 Caspofungin
35 Nebulized Liposomal Amphotericin B Ambisome for Prophylaxis of Invasive Pulmonary Aspergillosis Completed NCT00391014 Phase 2 liposomal Amphotericine B
36 Nebulized Amphotericin B Lipid Complex in Invasive Pulmonary Aspergillosis in Paediatric Patients With Acute Leukaemia Completed NCT01615809 Phase 2 AMPHOTERICIN B
37 A Study to Evaluate Isavuconazonium Sulfate for the Treatment of Invasive Aspergillosis (IA) or Invasive Mucormycosis (IM) in Pediatric Participants Recruiting NCT03816176 Phase 2 Isavuconazonium sulfate
38 Evaluate F901318 Treatment of Invasive Fungal Infections in Patients Lacking Treatment Options Recruiting NCT03583164 Phase 2 F901318
39 Isavuconazole in Preventing Invasive Fungal Infections in Adult Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome and Neutropenia Recruiting NCT03019939 Phase 2 Isavuconazole
40 Micafungin Salvage Mono-therapy in Invasive Aspergillosis Terminated NCT00376337 Phase 2 Micafungin;Systemic antifungal therapy
41 VL-2397 Compared to Standard First-Line Treatment for Invasive Aspergillosis (IA) in Adults Terminated NCT03327727 Phase 2 Investigational Agent: VL-2397;Standard treatment: Voriconazole, Isavuconazole, or Liposomal amphotericin B
42 Trial of Micafungin (FK463) in Combination With Liposomal Amphotericin B (AmBisome) for Aspergillosis Terminated NCT00047827 Phase 2 Micafungin;Liposomal Amphotericin B
43 Trial of Combination Antifungal Therapy (Vori+Mica vs. Vori+Placebo) in Invasive Aspergillosis Withdrawn NCT01207128 Phase 2 Voriconazole, micafungin
44 F901318 Multiple Ascending Dose Study Completed NCT02342574 Phase 1 F901318;Placebo
45 Assessment of Varying Oral Dosing Regimens for F901318 in Healthy Subjects Completed NCT03340597 Phase 1 F901318
46 Evaluation of Immediate Release Tablet Completed NCT02808741 Phase 1 F901318 SDD;F901318 IR;F901318 IR Fasting;F901318 IR Fed
47 Multiple Ascending Oral Dose Study of F901318 in Healthy Subjects Completed NCT02737371 Phase 1 F901318 Dose level A oral;Placebo dose level A oral;F901318 Dose level B oral;Placebo dose level B oral;F901318 Dose level C oral;Placebo Dose level C oral
48 Study of Potential for Interaction of Fluconazole With F901318 Completed NCT02730442 Phase 1 F901318;Fluconazole
49 Evaluation of the Potential for Cytochrome P450 3A4 Inhibition by F901318 Using Oral Midazolam as a Probe Completed NCT02680808 Phase 1 Midazolam with F901318
50 Single Ascending Oral Dose Study of F901318 Completed NCT02394483 Phase 1 F901318 safety;F901318 tolerability;F901318 pharmacokinetics

Search NIH Clinical Center for Invasive Aspergillosis

Genetic Tests for Invasive Aspergillosis

Anatomical Context for Invasive Aspergillosis

MalaCards organs/tissues related to Invasive Aspergillosis:

42
Testes, Liver, Myeloid, Bone, Bone Marrow, Heart, Thyroid

Publications for Invasive Aspergillosis

Articles related to Invasive Aspergillosis:

(show top 50) (show all 1337)
# Title Authors Year
1
Invasive aspergillosis manifesting as retinal necrosis in a patient treated with ruxolitinib. ( 30712951 )
2019
2
Correction: Combination Antifungal Therapy for Invasive Aspergillosis. ( 30716753 )
2019
3
Cost-effectiveness analysis of isavuconazole versus voriconazole for the treatment of patients with possible invasive aspergillosis in Sweden. ( 30744563 )
2019
4
Use of Aspergillus fumigatus real-time PCR in bronchoalveolar lavage samples (BAL) for diagnosis of invasive aspergillosis, including azole-resistant cases, in high risk haematology patients: the need for a combined use with galactomannan. ( 30753590 )
2019
5
Invasive Aspergillosis in Pediatric Leukemia Patients: Prevention and Treatment. ( 30754630 )
2019
6
Subacute invasive aspergillosis in a patient with cystic fibrosis. ( 30765333 )
2019
7
The Difficulty of Diagnosing Invasive Aspergillosis Initially Manifesting as Optic Neuropathy. ( 30792652 )
2019
8
Why are so many cases of invasive aspergillosis missed? ( 30816963 )
2019
9
How to make a fast diagnosis in invasive aspergillosis. ( 30816965 )
2019
10
Clinical-scale production of Aspergillus-specific T cells for the treatment of invasive aspergillosis in the immunocompromised host. ( 30867554 )
2019
11
Invasive Aspergillosis in solid-organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. ( 30900296 )
2019
12
Influenza and invasive aspergillosis in Immunocompromised patients. ( 30982862 )
2019
13
Tissue distribution and penetration of isavuconazole at the site of infection in Experimental Invasive Aspergillosis in Mice with underlying Chronic Granulomatous Disease. ( 30988140 )
2019
14
Detection of Invasive Aspergillosis in Critically Ill Patients with Influenza: the Role of Plasma Galactomannan. ( 31042411 )
2019
15
Baseline predictors influencing the prognosis of invasive aspergillosis in adults. ( 31066092 )
2019
16
Influenza coinfection: be(a)ware of invasive aspergillosis. ( 31077266 )
2019
17
Burden of hospitalizations over time with invasive aspergillosis in the United States, 2004-2013. ( 31101036 )
2019
18
Galactomannan detection in broncho-alveolar lavage fluid for invasive aspergillosis in immunocompromised patients. ( 31107543 )
2019
19
Aspergillus terreus Causing Probable Invasive Aspergillosis in a Patient with Cystic Fibrosis. ( 30168076 )
2019
20
In-vitro antifungal susceptibility testing of lanoconazole and luliconazole against Aspergillus flavus as an important agent of invasive aspergillosis. ( 30241879 )
2019
21
Triacetylfusarinine C: A urine biomarker for diagnosis of invasive aspergillosis. ( 30267801 )
2019
22
Mainly Post-Transplant Factors Are Associated with Invasive Aspergillosis after Allogeneic Stem Cell Transplantation: A Study from the Surveillance des Aspergilloses Invasives en France and Société Francophone de Greffe de Moelle et de Thérapie Cellulaire. ( 30268782 )
2019
23
Clinical Pharmacokinetics of Second-Generation Triazoles for the Treatment of Invasive Aspergillosis and Candidiasis. ( 30284178 )
2019
24
Outcomes by MIC Values for Patients Treated with Isavuconazole or Voriconazole for Invasive Aspergillosis in the Phase 3 SECURE and VITAL Trials. ( 30373791 )
2019
25
Managing invasive aspergillosis in haematological patients in the era of resistance polymerase chain reaction and increasing triazole resistance: A modelling study of different strategies. ( 30395989 )
2019
26
A case of fatal invasive aspergillosis in a patient with neurosarcoidosis treated with infliximab. ( 30430892 )
2019
27
Low risk of Pneumocystis jirovecii pneumonia and invasive aspergillosis in patients with Waldenström macroglobulinaemia on ibrutinib. ( 30460682 )
2019
28
In Silico Protein Interaction Network Analysis of Virulence Proteins Associated with Invasive Aspergillosis for Drug Discovery. ( 30465504 )
2019
29
Point-of-care diagnosis of invasive aspergillosis in non-neutropenic patients: Aspergillus Galactomannan Lateral Flow Assay versus Aspergillus-specific Lateral Flow Device test in bronchoalveolar lavage. ( 30565352 )
2019
30
Prevention of healthcare-associated invasive aspergillosis during hospital construction/renovation works. ( 30629998 )
2019
31
'Real-life' analysis of the role of antifungal prophylaxis in preventing invasive aspergillosis in AML patients undergoing consolidation therapy: Sorveglianza Epidemiologica Infezioni nelle Emopatie (SEIFEM) 2016 study. ( 30649413 )
2019
32
International Multicenter Experience in the Treatment Outcome of Invasive Aspergillosis in Immunocompromised Cancer Patients. ( 30671209 )
2019
33
Invasive aspergillosis complicating treatment with tyrosine kinase inhibitors. ( 30700454 )
2019
34
Invasive aspergillosis in patients following umbilical cord blood transplant. ( 29795425 )
2019
35
Applying host disease status biomarkers to therapeutic response monitoring in invasive aspergillosis patients. ( 29370415 )
2019
36
Invasive Aspergillosis in Refractory Angioimmunoblastic T-Cell Lymphoma. ( 29129826 )
2018
37
Invasive Aspergillosis After Kidney Transplant-Treatment Approach. ( 30814781 )
2018
38
Donor-derived invasive aspergillosis after kidney transplant. ( 30094135 )
2018
39
Clinical risk factors for invasive aspergillosis in lung transplant recipients: Results of an international cohort study. ( 30139546 )
2018
40
Invasive aspergillosis in patients with systemic lupus erythematosus: a retrospective study on clinical characteristics and risk factors for mortality. ( 30157715 )
2018
41
Invasive Aspergillosis. ( 30171061 )
2018
42
Invasive Aspergillosis in Children: Update on Current Guidelines. ( 30210741 )
2018
43
The performance of galactomannan in combination with 1,3-β-D-glucan or aspergillus-lateral flow device for the diagnosis of invasive aspergillosis: Evidences from 13 studies. ( 30279025 )
2018
44
Voriconazole Resistance and Mortality in Invasive Aspergillosis: A Multicenter Retrospective Cohort Study. ( 30307492 )
2018
45
Genotyping of Aspergillus fumigatus in Formalin-Fixed Paraffin-Embedded Tissues and Serum Samples From Patients With Invasive Aspergillosis. ( 30406050 )
2018
46
Association between polymorphisms in the genes encoding toll-like receptors and dectin-1 and susceptibility to invasive aspergillosis: a systematic review. ( 30517524 )
2018
47
Is Aspergillus lateral device ready to implement to the daily practice? The question rising from the new European Invasive Aspergillosis management guideline. ( 30522893 )
2018
48
Treating invasive aspergillosis in patients with hematologic malignancy: diagnostic-driven approach versus empiric therapies. ( 30545320 )
2018
49
The pharmacokinetic challenge of treating invasive aspergillosis complicating severe influenzae assisted by extracorporeal membrane oxygenation. ( 30577863 )
2018
50
Anogenital Ulcers: An Unusual Manifestation of Invasive Aspergillosis. ( 30662775 )
2018

Variations for Invasive Aspergillosis

Expression for Invasive Aspergillosis

Search GEO for disease gene expression data for Invasive Aspergillosis.

Pathways for Invasive Aspergillosis

Pathways related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 CLEC7A CXCL10 CXCL8 IFNG IL12B MBL2
2
Show member pathways
13.34 CXCL10 CXCL8 IL12B TLR1 TLR2 TLR4
3
Show member pathways
13.13 IFNG TLR1 TLR2 TLR4 TLR5 TLR6
4
Show member pathways
12.71 CXCL10 CXCL8 IFNG IL12B TLR4
5
Show member pathways
12.65 TLR1 TLR2 TLR4 TLR5 TLR6
6
Show member pathways
12.63 CXCL10 CXCL8 IFNG IL12B MBL2 SFTPD
7
Show member pathways
12.58 IL12B TLR1 TLR2 TLR4 TLR5 TLR6
8
Show member pathways
12.56 IFNG IL12B TLR2 TLR4 TLR5
9 12.53 CABIN1 CXCL10 IFNG TLR1 TLR2 TLR6
10
Show member pathways
12.41 TLR1 TLR2 TLR4 TLR6
11
Show member pathways
12.39 TLR1 TLR2 TLR4 TLR5 TLR6
12
Show member pathways
12.31 CXCL10 CXCL8 IFNG TLR2 TLR5
13
Show member pathways
12.21 IFNG IL12B TLR2 TLR4
14
Show member pathways
12.21 CXCL8 TLR1 TLR2 TLR4 TLR5 TLR6
15
Show member pathways
12.17 CXCL10 CXCL8 TLR1 TLR2 TLR4 TLR5
16 12.13 IFNG TLR1 TLR2 TLR4 TLR5 TLR6
17
Show member pathways
12.09 CXCL8 TLR2 TLR5
18 12.06 CLEC7A MBL2 SFTPD TLR2 TLR4 TLR6
19 12.05 CLEC7A IFNG IL12B TLR1 TLR2 TLR4
20
Show member pathways
12.01 IFNG TLR1 TLR2 TLR4 TLR6
21 12 CXCL10 CXCL8 IFNG TLR4
22
Show member pathways
11.99 TLR1 TLR2 TLR4 TLR5 TLR6
23 11.87 CXCL8 IFNG TLR2 TLR4
24 11.86 CXCL8 IFNG IL12B TLR2 TLR4
25 11.83 CXCL8 IFNG TLR4 TLR5
26
Show member pathways
11.81 CXCL8 IL12B TLR4
27
Show member pathways
11.81 IFNG IL12B TLR1 TLR2 TLR4 TLR5
28 11.73 CLEC7A TLR1 TLR2 TLR4 TLR5 TLR6
29
Show member pathways
11.71 CABIN1 CXCL8 IFNG
30 11.71 CXCL8 IL12B TLR4
31 11.55 CXCL8 IFNG TLR2 TLR4
32 11.53 IFNG IL12B TLR2 TLR4
33 11.51 CXCL10 CXCL8 IL12B
34 11.51 CXCL8 IL12B TLR2 TLR4 TLR5
35
Show member pathways
11.49 CXCL10 CXCL8 IFNG SFTPD TLR1 TLR2
36 11.19 IFNG TLR1 TLR2
37 11.14 IFNG IL12B
38
Show member pathways
11.13 IFNG IL12B
39 11.09 CXCL10 CXCL8 IL12B

GO Terms for Invasive Aspergillosis

Cellular components related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytic vesicle membrane GO:0030670 9.13 TLR1 TLR2 TLR6
2 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.98 CXCL10 CXCL8 IFNG TLR1 TLR2 TLR4
2 immune system process GO:0002376 9.97 CLEC7A MBL2 SFTPD TLR1 TLR2 TLR4
3 cell surface receptor signaling pathway GO:0007166 9.96 CABIN1 CXCL10 IFNG IL12B
4 defense response to bacterium GO:0042742 9.92 MBL2 SFTPD TLR4 TLR5 TLR6
5 innate immune response GO:0045087 9.92 CLEC7A MBL2 SFTPD TLR1 TLR2 TLR4
6 defense response to virus GO:0051607 9.91 CXCL10 IFNG IL12B
7 response to lipopolysaccharide GO:0032496 9.91 CXCL10 TLR2 TLR4
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.9 TLR2 TLR4 TLR6
9 defense response GO:0006952 9.9 CXCL10 CXCL8 TLR1
10 cell cycle arrest GO:0007050 9.89 CXCL8 IFNG IL12B
11 cellular response to lipopolysaccharide GO:0071222 9.88 CXCL10 CXCL8 IL12B TLR4 TLR5
12 cellular response to interferon-gamma GO:0071346 9.86 IL12B TLR2 TLR4
13 positive regulation of inflammatory response GO:0050729 9.84 IL12B TLR2 TLR4
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 IL12B TLR2 TLR4
15 positive regulation of tumor necrosis factor production GO:0032760 9.81 IL12B TLR2 TLR4
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 IFNG TLR4 TLR5 TLR6
17 positive regulation of interferon-beta production GO:0032728 9.73 TLR2 TLR4
18 leukocyte chemotaxis GO:0030595 9.73 CXCL10 CXCL8
19 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.73 TLR4 TLR6
20 positive regulation of osteoclast differentiation GO:0045672 9.72 IFNG IL12B
21 defense response to protozoan GO:0042832 9.72 CLEC7A IL12B
22 positive regulation of chemokine production GO:0032722 9.72 TLR2 TLR4
23 positive regulation of interleukin-8 production GO:0032757 9.72 TLR2 TLR4 TLR5
24 microglial cell activation GO:0001774 9.71 TLR2 TLR6
25 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.71 TLR4 TLR6
26 positive regulation of macrophage activation GO:0043032 9.71 TLR4 TLR6
27 negative regulation of growth of symbiont in host GO:0044130 9.71 IL12B MBL2
28 positive regulation of interleukin-10 production GO:0032733 9.71 IL12B TLR2 TLR4
29 positive regulation of interleukin-12 production GO:0032735 9.71 IFNG IL12B TLR2 TLR4
30 positive regulation of interleukin-8 secretion GO:2000484 9.7 TLR1 TLR2
31 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.7 TLR2 TLR4
32 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.7 TLR4 TLR6
33 I-kappaB phosphorylation GO:0007252 9.7 TLR2 TLR4
34 interferon-gamma production GO:0032609 9.69 IL12B TLR4
35 response to molecule of bacterial origin GO:0002237 9.69 CXCL8 TLR2
36 cell activation GO:0001775 9.69 TLR1 TLR2 TLR6
37 macrophage activation GO:0042116 9.68 TLR1 TLR4
38 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.68 TLR1 TLR4
39 cellular response to lipoteichoic acid GO:0071223 9.68 TLR2 TLR4
40 T-helper 1 type immune response GO:0042088 9.67 IL12B TLR4
41 positive regulation of lymphocyte proliferation GO:0050671 9.67 IL12B TLR4
42 positive regulation of smooth muscle cell apoptotic process GO:0034393 9.67 IFNG IL12B
43 negative regulation of interleukin-17 production GO:0032700 9.67 IFNG IL12B TLR4
44 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.65 TLR4 TLR6
45 interleukin-1 beta secretion GO:0050702 9.65 TLR4 TLR6
46 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.65 TLR1 TLR6
47 toll-like receptor signaling pathway GO:0002224 9.65 SFTPD TLR1 TLR2 TLR4 TLR6
48 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.64 TLR4 TLR6
49 cellular response to diacyl bacterial lipopeptide GO:0071726 9.63 TLR2 TLR6
50 positive regulation of toll-like receptor signaling pathway GO:0034123 9.62 TLR2 TLR5

Molecular functions related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.93 IL12B SFTPD TLR1 TLR2 TLR4 TLR6
2 signaling receptor binding GO:0005102 9.8 CXCL10 MBL2 TLR4 TLR6
3 protein heterodimerization activity GO:0046982 9.8 IL12B TLR1 TLR2 TLR4 TLR6
4 signaling receptor activity GO:0038023 9.73 TLR1 TLR2 TLR4 TLR6
5 transmembrane signaling receptor activity GO:0004888 9.67 TLR1 TLR4 TLR5 TLR6
6 cytokine activity GO:0005125 9.62 CXCL10 CXCL8 IFNG IL12B
7 signaling pattern recognition receptor activity GO:0008329 9.48 CLEC7A TLR2
8 lipopolysaccharide receptor activity GO:0001875 9.26 TLR2 TLR4
9 Toll-like receptor 2 binding GO:0035663 9.16 TLR1 TLR6
10 lipopolysaccharide binding GO:0001530 9.13 SFTPD TLR2 TLR4
11 lipopeptide binding GO:0071723 8.8 TLR1 TLR2 TLR6

Sources for Invasive Aspergillosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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