MCID: INV001
MIFTS: 52

Invasive Aspergillosis

Categories: Genetic diseases, Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Invasive Aspergillosis

MalaCards integrated aliases for Invasive Aspergillosis:

Name: Invasive Aspergillosis 12 15 73
Aspergillosis Invasive 55

Classifications:



External Ids:

Disease Ontology 12 DOID:0050073
UMLS 73 C0238013

Summaries for Invasive Aspergillosis

Disease Ontology : 12 An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.

MalaCards based summary : Invasive Aspergillosis, also known as aspergillosis invasive, is related to aspergillosis and candidiasis. An important gene associated with Invasive Aspergillosis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Caspofungin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, myeloid and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Invasive Aspergillosis

Diseases in the Aspergillosis family:

Invasive Aspergillosis

Diseases related to Invasive Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 233)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 32.0 CLEC7A IFNG MBL2 SFTPD TLR2 TLR4
2 candidiasis 30.7 CLEC7A IFNG MBL2
3 cystic fibrosis 29.9 CXCL8 MBL2 SFTPD TLR4
4 ulcerative colitis 29.7 CXCL8 IFNG TLR4
5 colitis 29.7 CXCL8 IFNG TLR4 TLR9
6 cryptococcosis 29.6 IFNG MBL2 TLR9
7 pulmonary disease, chronic obstructive 29.4 CXCL10 CXCL8 SFTPD TLR2
8 pneumonia 29.3 CXCL8 MBL2 SFTPD TLR2 TLR4 TLR9
9 systemic lupus erythematosus 29.0 CXCL10 CXCL8 IFNG MBL2 TLR2 TLR4
10 rheumatoid arthritis 28.9 CXCL8 IFNG TLR2 TLR4
11 leukemia 10.4
12 hematopoietic stem cell transplantation 10.4
13 leukemia, acute myeloid 10.3
14 myeloid leukemia 10.3
15 chronic granulomatous disease 10.3
16 variola major 10.2 IFNG TLR4
17 mucormycosis 10.2
18 campylobacteriosis 10.2 IFNG TLR4
19 common wart 10.2 CLEC7A CXCL8
20 lymphocytic leukemia 10.2
21 pouchitis 10.2 CXCL8 TLR4
22 pericardial tuberculosis 10.2 CABIN1 IFNG
23 cardiac sarcoidosis 10.2 CXCL8 IFNG
24 scabies 10.2 CXCL8 MBL2
25 coccidioidomycosis 10.2 CLEC7A MBL2 TLR4
26 neutropenia 10.2
27 clonorchiasis 10.2 CXCL8 IFNG
28 ascaris lumbricoides infection 10.2 CXCL8 IFNG
29 crohn's colitis 10.2 CXCL8 IFNG
30 superficial urinary bladder cancer 10.2 CXCL8 TLR4
31 meconium aspiration syndrome 10.2 CXCL8 IFNG
32 endometrial disease 10.1 CXCL8 TLR4
33 urethritis 10.1 TLR1 TLR6
34 brucellosis 10.1 CXCL8 IFNG TLR4
35 pyelitis 10.1 CXCL8 TLR4
36 lymphadenitis 10.1 CXCL8 IFNG TLR4
37 periodontosis 10.1 CXCL8 TLR4
38 leukemia, acute lymphoblastic 10.1
39 acute leukemia 10.1
40 adult dermatomyositis 10.1 MBL2 TLR9
41 cardiac rupture 10.1 CXCL8 FLNC
42 bacteriuria 10.1 CXCL8 TLR1 TLR4
43 meningococcal meningitis 10.1 MBL2 TLR9
44 influenza 10.1
45 lupus erythematosus 10.1
46 ariboflavinosis 10.1 TLR4 TLR6
47 central nervous system vasculitis 10.1 IFNG TLR9
48 peanut allergy 10.1 CXCL10 IFNG
49 hyper ige syndrome 10.0 IFNG TLR4
50 asymptomatic neurosyphilis 10.0 CXCL10 CXCL8 IFNG

Graphical network of the top 20 diseases related to Invasive Aspergillosis:



Diseases related to Invasive Aspergillosis

Symptoms & Phenotypes for Invasive Aspergillosis

GenomeRNAi Phenotypes related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.5 MBL2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.5 TLR4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.5 MBL2 TLR4 TLR6
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.5 TLR6
5 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.5 TLR4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.5 TLR4
7 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.5 TLR6
8 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.5 MBL2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.5 MBL2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.5 MBL2 TLR6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.5 MBL2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.5 TLR6

MGI Mouse Phenotypes related to Invasive Aspergillosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 CABIN1 CLEC7A CXCL10 IFNG MBL2 SFTPD
2 homeostasis/metabolism MP:0005376 9.81 CLEC7A CXCL10 FLNC IFNG MBL2 SFTPD
3 immune system MP:0005387 9.7 CABIN1 CLEC7A CXCL10 IFNG MBL2 SFTPD
4 respiratory system MP:0005388 9.1 CLEC7A FLNC IFNG SFTPD TLR2 TLR4

Drugs & Therapeutics for Invasive Aspergillosis

Drugs for Invasive Aspergillosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caspofungin Approved Phase 4,Phase 3,Phase 2,Not Applicable 179463-17-3, 162808-62-0 468682 2826718
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
3
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137234-62-9 71616
4
Amphotericin B Approved, Investigational Phase 4,Phase 2,Phase 3 1397-89-3 5280965 14956
5
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 171228-49-2 147912
6
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
7
Anidulafungin Approved, Investigational Phase 4,Phase 3,Phase 2 166663-25-8 166548
8
Itraconazole Approved, Investigational Phase 4,Phase 3 84625-61-6 55283
9
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
10
Mycophenolic acid Approved Phase 4 24280-93-1 446541
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Echinocandins Phase 4,Phase 3,Phase 2
13 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
14 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Liposomal amphotericin B Phase 4,Phase 2,Phase 3
21 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
22 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
23 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
24 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25
Hydroxyitraconazole Phase 4,Phase 3
26 glucocorticoids Phase 4,Phase 3
27 Pharmaceutical Solutions Phase 4,Phase 3
28 Immunosuppressive Agents Phase 4,Phase 1
29
Midazolam Approved, Illicit Phase 2, Phase 3,Phase 1 59467-70-8 4192
30
deoxycholic acid Approved Phase 3 83-44-3 222528
31
Aldesleukin Approved Phase 3 85898-30-2, 110942-02-4
32
Fluconazole Approved, Investigational Phase 3,Phase 1 86386-73-4 3365
33
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
34
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
35 Amphotericin B, deoxycholate drug combination Phase 3
36 Gastrointestinal Agents Phase 3,Phase 1
37 Cholagogues and Choleretics Phase 3
38 Peripheral Nervous System Agents Phase 3
39 Antiviral Agents Phase 3,Phase 2
40 Analgesics Phase 3
41 Anti-HIV Agents Phase 3
42 Anti-Retroviral Agents Phase 3
43 Analgesics, Non-Narcotic Phase 3
44 Interleukin-2 Phase 3
45 Cytochrome P-450 CYP2C19 Inhibitors Phase 3,Phase 1
46 Antineoplastic Agents, Hormonal Phase 3
47 Anti-Inflammatory Agents Phase 3
48 Antiemetics Phase 3
49 HIV Protease Inhibitors Phase 3
50
protease inhibitors Phase 3

Interventional clinical trials:

(show top 50) (show all 93)
# Name Status NCT ID Phase Drugs
1 COMBISTRAT: AmBisome® in Combination With Caspofungin for the Treatment of Invasive Aspergillosis Completed NCT00334412 Phase 4 Ambisome;caspofungin
2 CYP2C19 Genotype-Specific Dosing Plus TDM on Reaching Therapeutic Voriconazole Blood Levels Recruiting NCT03731169 Phase 4 Standard of Care
3 King's Invasive Aspergillosis Study II Active, not recruiting NCT02875743 Phase 4 Posaconazole
4 Posaconazole Pharmacokinetics in Patients Receiving Chemotherapy or Stem Cell Transplants Not yet recruiting NCT03717623 Phase 4 Posaconazole pharmacokinetics
5 Post Marketing Study to Evaluate the Efficacy and Safety of Micafungin Treatment on Invasive Aspergillosis Terminated NCT02646774 Phase 4 Micafungin
6 Study to Test the Combination of Voriconazole and Anidulafungin in Patients Who Have, or Are Thought to Have, Invasive Aspergillosis and Who Are Unable to Take a Common Antifungal Therapy (Polyene) Terminated NCT00620074 Phase 4 voriconazole;anidulafungin
7 Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients Terminated NCT01282879 Phase 4 Itraconazole
8 A Study to Evaluate the Effectiveness of Voriconazole + Micafungin Versus Voriconazole Alone for Invasive Aspergillosis Withdrawn NCT00423163 Phase 4 micafungin;voriconazole
9 A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients Completed NCT00163722 Phase 3
10 Anidulafungin Plus Voriconazole Versus Voriconazole For The Treatment Of Invasive Aspergillosis Completed NCT00531479 Phase 3 voriconazole;anidulafungin;voriconazole
11 A Safety & Effectiveness Study of Intravenous Anidulafungin With AmBisome® for Treatment of Invasive Aspergillosis (IA). Completed NCT00037206 Phase 2, Phase 3 Anidulafungin, VER002
12 Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis Completed NCT00001646 Phase 3 Voriconazole;Amphotericin B
13 Study Safety/Efficacy of AmBisome Loading Dose Regimen Versus Standard AmBisome Regimen for Initial Treatment Completed NCT00158730 Phase 3 AmBisome
14 Isavuconazole (BAL8557) for Primary Treatment of Invasive Aspergillosis Completed NCT00412893 Phase 3 Isavuconazole;Voriconazole
15 Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis Completed NCT00263315 Phase 2, Phase 3 nebulised liposomal amphotericin B
16 To Determine Whether Galactomannan Test Will Help to Detect Fungal Infections Early and Hence Start Treatment Early Completed NCT00361517 Phase 3 Amphotericin-B deoxycholate
17 Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis Completed NCT00003031 Phase 3 amphotericin B deoxycholate;voriconazole
18 Pharmacokinetic Profiles of Inhaled Lipid Complex Amphotericin B (Abelcet ®) Completed NCT00177684 Phase 3 Amphotericin B
19 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
20 Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101) Completed NCT02180165 Phase 3 Posaconazole;Voriconazole
21 Caspofungin Acetate or Fluconazole in Preventing Invasive Fungal Infections in Patients With Acute Myeloid Leukemia Who Are Undergoing Chemotherapy Completed NCT01307579 Phase 3 Caspofungin Acetate;Fluconazole
22 Safety and Effectiveness of Granulocyte Transfusions in Resolving Infection in People With Neutropenia (The RING Study) Completed NCT00627393 Phase 3 Standard antimicrobial therapy;G-CSF/dexamethasone
23 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
24 Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi Completed NCT00634049 Phase 3 isavuconazole
25 A Study of the Safety and Efficacy of Posaconazole Versus Voriconazole for the Treatment of Invasive Aspergillosis (MK-5592-069) Recruiting NCT01782131 Phase 3 Posaconazole;Voriconazole
26 A Study To Evaluate The Safety Of Voriconazole As Treatment Of Invasive Aspergillosis (Fungal Infection) And Other Rare Molds In Children Terminated NCT00836875 Phase 3 Voriconazole
27 Voriconazole And Anidulafungin Combination For Invasive Aspergillosis In Pediatric Subjects Withdrawn NCT01188759 Phase 3 Voriconazole;Anidulafungin;Voriconazole
28 Prophylaxis With Caspofungin in High-Risk Liver Transplantation Unknown status NCT00333645 Phase 2 Caspofungin
29 Caspofungin Maximum Tolerated Dose in Patients With Invasive Aspergillosis Completed NCT00404092 Phase 2 caspofungin
30 MK0991 in Combination With Standard Antifungal Agent(s) for the Treatment of Salvage Invasive Aspergillosis (0991-037) Completed NCT00076869 Phase 2 MK0991, caspofungin acetate;Comparator: amphotericin B;Comparator: lipid formulation of amphotericin B and/or azole
31 Study of FK463 for the Treatment of Invasive Aspergillosis Completed NCT00036166 Phase 2 FK463
32 Voriconazole With or Without Interferon Gamma in Treating Patients With Aspergillosis or Other Fungal Infections Completed NCT00059878 Phase 2 voriconazole
33 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
34 Prophylaxis of Fungal Invasive Infections in Leukemia Completed NCT00501098 Phase 2 Caspofungin
35 Nebulized Liposomal Amphotericin B Ambisome for Prophylaxis of Invasive Pulmonary Aspergillosis Completed NCT00391014 Phase 2 liposomal Amphotericine B
36 Nebulized Amphotericin B Lipid Complex in Invasive Pulmonary Aspergillosis in Paediatric Patients With Acute Leukaemia Completed NCT01615809 Phase 2 AMPHOTERICIN B
37 VL-2397 Compared to Standard First-Line Treatment for Invasive Aspergillosis (IA) in Adults Recruiting NCT03327727 Phase 2 Investigational Agent: VL-2397;Standard treatment: Voriconazole, Isavuconazole, or Liposomal amphotericin B
38 Study of Isavuconazole Prophylaxis in Adults With Acute Myeloid Leukemia/Myelodysplastic Syndrome (AML/MDS) and Neutropenia Recruiting NCT03019939 Phase 2 Isavuconazole
39 Evaluate F901318 Treatment of Invasive Fungal Infections in Patients Lacking Treatment Options Recruiting NCT03583164 Phase 2 F901318
40 A Study to Evaluate Isavuconazonium Sulfate for the Treatment of Invasive Aspergillosis (IA) or Invasive Mucormycosis (IM) in Pediatric Participants Not yet recruiting NCT03816176 Phase 2 Isavuconazonium sulfate
41 Micafungin Salvage Mono-therapy in Invasive Aspergillosis Terminated NCT00376337 Phase 2 Micafungin;Systemic antifungal therapy
42 Trial of Micafungin (FK463) in Combination With Liposomal Amphotericin B (AmBisome) for Aspergillosis Terminated NCT00047827 Phase 2 Micafungin;Liposomal Amphotericin B
43 Trial of Combination Antifungal Therapy (Vori+Mica vs. Vori+Placebo) in Invasive Aspergillosis Withdrawn NCT01207128 Phase 2 Voriconazole, micafungin
44 F901318 Multiple Ascending Dose Study Completed NCT02342574 Phase 1 F901318;Placebo
45 Assessment of Varying Oral Dosing Regimens for F901318 in Healthy Subjects Completed NCT03340597 Phase 1 F901318
46 Evaluation of Immediate Release Tablet Completed NCT02808741 Phase 1 F901318 SDD;F901318 IR;F901318 IR Fasting;F901318 IR Fed
47 Multiple Ascending Oral Dose Study of F901318 in Healthy Subjects Completed NCT02737371 Phase 1 F901318 Dose level A oral;Placebo dose level A oral;F901318 Dose level B oral;Placebo dose level B oral;F901318 Dose level C oral;Placebo Dose level C oral
48 Study of Potential for Interaction of Fluconazole With F901318 Completed NCT02730442 Phase 1 F901318;Fluconazole
49 Evaluation of the Potential for Cytochrome P450 3A4 Inhibition by F901318 Using Oral Midazolam as a Probe Completed NCT02680808 Phase 1 Midazolam with F901318
50 Single Ascending Oral Dose Study of F901318 Completed NCT02394483 Phase 1 F901318 safety;F901318 tolerability;F901318 pharmacokinetics

Search NIH Clinical Center for Invasive Aspergillosis

Genetic Tests for Invasive Aspergillosis

Anatomical Context for Invasive Aspergillosis

MalaCards organs/tissues related to Invasive Aspergillosis:

41
Lung, Myeloid, Testes, Liver, Bone, Bone Marrow, Heart

Publications for Invasive Aspergillosis

Articles related to Invasive Aspergillosis:

(show top 50) (show all 1023)
# Title Authors Year
1
The diagnosis and treatment of invasive aspergillosis in Dutch haematology units facing a rapidly increasing prevalence of azole-resistance. A nationwide survey and rationale for the DB-MSG 002 study protocol. ( 29687483 )
2018
2
Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy. ( 29750016 )
2018
3
Performance of serum (1,3)-A9-d-glucan screening for the diagnosis of invasive aspergillosis in neutropenic patients with haematological malignancies. ( 29693758 )
2018
4
Early-onset invasive aspergillosis and other fungal infections in patients treated with ibrutinib. ( 29437588 )
2018
5
Subacute invasive aspergillosis associated with sorafenib therapy for hepatocellular carcinoma. ( 29370392 )
2018
6
Predicting Invasive Aspergillosis in Hematology Patients by Combining Clinical and Genetic Risk Factors with Early Diagnostic Biomarkers. ( 29118175 )
2018
7
How we approach combination antifungal therapy for invasive aspergillosis and mucormycosis in transplant recipients. ( 29975240 )
2018
8
Chitinase Induction Prior to Caspofungin Treatment of Experimental Invasive Aspergillosis in Neutropenic Rats Does Not Enhance Survival. ( 29084744 )
2018
9
Cost-effectiveness analysis of interventions for prevention of invasive aspergillosis among leukemia patients during hospital construction activities. ( 29105850 )
2018
10
Invasive aspergillosis in patients following umbilical cord blood transplant. ( 29795425 )
2018
11
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis. ( 29980664 )
2018
12
Breakthrough invasive aspergillosis and diagnostic accuracy of serum galactomannan enzyme immune assay during acute myeloid leukemia induction chemotherapy with posaconazole prophylaxis. ( 29928481 )
2018
13
Galactomannan antigenemia as a biomarker for therapeutic response of invasive aspergillosis: implications for clinical trial design and patient care. ( 29897826 )
2018
14
Multiple small bowel perforations due to invasive aspergillosis in a patient with acute myeloid leukemia: case report and a systematic review of the literature. ( 29357049 )
2018
15
Diagnosis of Invasive Aspergillosis in Hematological Malignancy Patients: Performance of Cytokines, Asp LFD, and Aspergillus PCR in Same Day Blood and Bronchoalveolar Lavage Samples. ( 29972764 )
2018
16
The burden of Invasive Aspergillosis in patients with haematological malignancy: A meta-analysis and systematic review. ( 29727605 )
2018
17
Invasive Aspergillosis Mimicking Metastatic Lung Cancer. ( 29922593 )
2018
18
Galactomannan, a Surrogate Marker for Outcome in Invasive Aspergillosis: Finally Coming of Age. ( 29670608 )
2018
19
Invasive Aspergillosis with Pulmonary and Central Nervous System involvement during ibrutinib therapy for relapsed Chronic Lymphocytic Leukaemia, a case report. ( 29427802 )
2018
20
Epidemiology and Outcomes of Hospitalizations With Invasive Aspergillosis in the United States, 2009-2013. ( 29718296 )
2018
21
Characterisation of the cellular and proteomic response of Galleria mellonella larvae to the development of invasive aspergillosis. ( 29954319 )
2018
22
Outbreak of invasive aspergillosis in heart transplant recipients: The role of screening computed tomography scans in asymptomatic patients and universal antifungal prophylaxis. ( 29125713 )
2018
23
Massive haemoptysis secondary to mycotic pulmonary artery aneurysm in subacute invasive aspergillosis. ( 29674397 )
2018
24
Local retrospective analysis of galactomannan cut-off values in bronchoalveolar lavage fluids for diagnosis of invasive aspergillosis. ( 29846912 )
2018
25
Production of the Invasive Aspergillosis Biomarker Bis(methylthio)gliotoxin Within the Genus <i>Aspergillus: In Vitro and in Vivo</i> Metabolite Quantification and Genomic Analysis. ( 29946309 )
2018
26
Epidemiology of invasive aspergillosis and triazole-resistant Aspergillus fumigatus in patients with haematological malignancies: a single-centre retrospective cohort study. ( 29394399 )
2018
27
Improving the diagnosis of invasive aspergillosis by the detection of Aspergillus in broncho-alveolar lavage fluid: Comparison of non-culture-based assays. ( 29248586 )
2018
28
Use of Galactomannan Antigen and Aspergillus DNA Real-time Polymerase Chain Reaction as Routine Methods for Invasive Aspergillosis in Immunosuppressed Children in Greece. ( 29807668 )
2018
29
Urine Antigen Detection as an Aid to Diagnose Invasive Aspergillosis. ( 29684106 )
2018
30
Outcomes by Minimum Inhibitory Concentrations for Patients Treated with Isavuconazole or Voriconazole for Invasive Aspergillosis in the Phase 3 SECURE and VITAL Trials. ( 30373791 )
2018
31
Managing Invasive Aspergillosis in haematological patients in the era of resistance PCR and increasing triazole resistance: a modelling study of different strategies. ( 30395989 )
2018
32
Genotyping of Aspergillus fumigatus in Formalin-Fixed Paraffin-Embedded Tissues and Serum Samples From Patients With Invasive Aspergillosis. ( 30406050 )
2018
33
A case of fatal invasive aspergillosis in a patient with neurosarcoidosis treated with infliximab. ( 30430892 )
2018
34
Low risk of Pneumocystis jirovecii pneumonia and invasive aspergillosis in patients with Waldenström macroglobulinaemia on ibrutinib. ( 30460682 )
2018
35
In silico protein interaction network analysis of virulence proteins associated with invasive aspergillosis for drug discovery. ( 30465504 )
2018
36
Association between polymorphisms in the genes encoding toll-like receptors and dectin-1 and susceptibility to invasive aspergillosis: a systematic review. ( 30517524 )
2018
37
Is Aspergillus lateral device ready to implement to the daily practice? The question rising from the new European Invasive Aspergillosis management guideline. ( 30522893 )
2018
38
Treating invasive aspergillosis in patients with hematologic malignancy: diagnostic-driven approach versus empiric therapies. ( 30545320 )
2018
39
Epidemiology, risk factors and outcomes of invasive aspergillosis in solid organ transplant recipients in the Swiss Transplant Cohort Study. ( 29668068 )
2018
40
Serum galactomannan antigen as a prognostic and diagnostic marker for invasive aspergillosis in heterogeneous medicine ICU patient population. ( 29684057 )
2018
41
Systematic review and network meta-analysis of clinical outcomes associated with isavuconazole versus relevant comparators for patients with invasive aspergillosis. ( 30022696 )
2018
42
Airborne Aspergillus fumigatus spore concentration during demolition of a building on a hospital site, and patient risk determination for invasive aspergillosis including azole resistance. ( 30056016 )
2018
43
Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study. ( 30076119 )
2018
44
Let's add invasive aspergillosis to the list of influenza complications. ( 30076120 )
2018
45
Donor-derived invasive aspergillosis after kidney transplant. ( 30094135 )
2018
46
Clinical risk factors for invasive aspergillosis in lung transplant recipients: Results of an international cohort study. ( 30139546 )
2018
47
Invasive aspergillosis in patients with systemic lupus erythematosus: a retrospective study on clinical characteristics and risk factors for mortality. ( 30157715 )
2018
48
Aspergillus terreus Causing Probable Invasive Aspergillosis in a Patient with Cystic Fibrosis. ( 30168076 )
2018
49
Invasive Aspergillosis. ( 30171061 )
2018
50
Invasive Aspergillosis in Children: Update on Current Guidelines. ( 30210741 )
2018

Variations for Invasive Aspergillosis

Expression for Invasive Aspergillosis

Search GEO for disease gene expression data for Invasive Aspergillosis.

Pathways for Invasive Aspergillosis

Pathways related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 CLEC7A CXCL10 CXCL8 IFNG MBL2 TLR1
2
Show member pathways
13.31 CXCL10 CXCL8 TLR1 TLR2 TLR4 TLR6
3
Show member pathways
13.11 IFNG TLR1 TLR2 TLR4 TLR6 TLR9
4
Show member pathways
12.7 CXCL10 CXCL8 IFNG TLR2 TLR4 TLR9
5
Show member pathways
12.62 CXCL10 CXCL8 IFNG TLR4
6
Show member pathways
12.62 TLR1 TLR2 TLR4 TLR6 TLR9
7
Show member pathways
12.54 TLR1 TLR2 TLR4 TLR6 TLR9
8
Show member pathways
12.51 CXCL10 CXCL8 IFNG MBL2 SFTPD TLR1
9 12.49 CABIN1 CXCL10 IFNG TLR1 TLR2 TLR6
10
Show member pathways
12.39 TLR1 TLR2 TLR4 TLR6
11
Show member pathways
12.35 TLR1 TLR2 TLR4 TLR6 TLR9
12
Show member pathways
12.27 CXCL10 CXCL8 IFNG TLR2
13
Show member pathways
12.23 CXCL8 TLR1 TLR2 TLR4 TLR6 TLR9
14
Show member pathways
12.17 CXCL10 CXCL8 TLR1 TLR2 TLR4 TLR6
15 12.15 IFNG TLR1 TLR2 TLR4 TLR6 TLR9
16
Show member pathways
12.1 IFNG TLR2 TLR4
17 12.06 CLEC7A MBL2 SFTPD TLR2 TLR4 TLR6
18
Show member pathways
12.01 IFNG TLR1 TLR2 TLR4 TLR6
19
Show member pathways
11.99 TLR1 TLR2 TLR4 TLR6 TLR9
20 11.97 CXCL10 CXCL8 IFNG TLR4
21 11.95 CLEC7A IFNG TLR1 TLR2 TLR4 TLR6
22
Show member pathways
11.91 IFNG TLR1 TLR2 TLR4 TLR6 TLR9
23 11.85 CXCL8 IFNG TLR2 TLR4
24 11.81 CXCL8 IFNG TLR2 TLR4
25 11.78 CXCL8 FLNC IFNG TLR4
26
Show member pathways
11.69 CABIN1 CXCL8 IFNG
27 11.66 CLEC7A TLR1 TLR2 TLR4 TLR6 TLR9
28 11.54 CXCL8 TLR2 TLR4
29
Show member pathways
11.49 CXCL10 CXCL8 IFNG SFTPD TLR1 TLR2
30 11.48 IFNG TLR2 TLR4
31 11.46 CXCL8 IFNG TLR2 TLR4 TLR9
32 11.15 IFNG TLR1 TLR2

GO Terms for Invasive Aspergillosis

Cellular components related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytic vesicle membrane GO:0030670 9.13 TLR1 TLR2 TLR6
2 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.97 CLEC7A MBL2 SFTPD TLR1 TLR2 TLR4
2 defense response to bacterium GO:0042742 9.92 MBL2 SFTPD TLR4 TLR6 TLR9
3 immune response GO:0006955 9.92 CXCL10 CXCL8 IFNG TLR1 TLR2 TLR4
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 TLR2 TLR4 TLR6 TLR9
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.9 TLR4 TLR6 TLR9
6 response to lipopolysaccharide GO:0032496 9.9 CXCL10 TLR2 TLR4
7 cellular response to lipopolysaccharide GO:0071222 9.9 CXCL10 CXCL8 TLR4
8 defense response GO:0006952 9.89 CXCL10 CXCL8 TLR1
9 positive regulation of inflammatory response GO:0050729 9.86 TLR2 TLR4 TLR9
10 positive regulation of interleukin-6 production GO:0032755 9.85 TLR2 TLR4 TLR9
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 TLR2 TLR4 TLR9
12 positive regulation of tumor necrosis factor production GO:0032760 9.83 TLR2 TLR4 TLR9
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IFNG TLR4 TLR6
14 inflammatory response GO:0006954 9.76 CLEC7A CXCL10 CXCL8 TLR1 TLR2 TLR4
15 positive regulation of interleukin-8 production GO:0032757 9.74 TLR2 TLR4 TLR9
16 negative regulation of interleukin-6 production GO:0032715 9.73 TLR4 TLR9
17 positive regulation of interferon-beta production GO:0032728 9.73 TLR2 TLR4 TLR9
18 positive regulation of interleukin-12 production GO:0032735 9.73 IFNG TLR2 TLR4 TLR9
19 leukocyte chemotaxis GO:0030595 9.72 CXCL10 CXCL8
20 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.72 TLR4 TLR6
21 positive regulation of interleukin-10 production GO:0032733 9.72 TLR2 TLR4 TLR9
22 microglial cell activation GO:0001774 9.71 TLR2 TLR6
23 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.71 TLR4 TLR6
24 positive regulation of macrophage activation GO:0043032 9.71 TLR4 TLR6
25 positive regulation of interleukin-8 secretion GO:2000484 9.71 TLR1 TLR2
26 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.71 TLR4 TLR6
27 positive regulation of chemokine production GO:0032722 9.71 TLR2 TLR4 TLR9
28 negative regulation of interleukin-17 production GO:0032700 9.7 IFNG TLR4
29 macrophage activation GO:0042116 9.7 TLR1 TLR4
30 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.7 TLR1 TLR4
31 cellular response to lipoteichoic acid GO:0071223 9.69 TLR2 TLR4
32 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR4 TLR9
33 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.69 TLR2 TLR4 TLR9
34 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.68 TLR4 TLR6
35 interleukin-1 beta secretion GO:0050702 9.68 TLR4 TLR6
36 positive regulation of interferon-beta biosynthetic process GO:0045359 9.68 TLR4 TLR9
37 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.68 TLR1 TLR6
38 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.67 TLR4 TLR6
39 positive regulation of interleukin-18 production GO:0032741 9.67 TLR2 TLR9
40 cell activation GO:0001775 9.67 TLR1 TLR2 TLR6
41 tumor necrosis factor production GO:0032640 9.66 TLR2 TLR9
42 cellular response to diacyl bacterial lipopeptide GO:0071726 9.65 TLR2 TLR6
43 positive regulation of toll-like receptor signaling pathway GO:0034123 9.65 TLR2 TLR9
44 I-kappaB phosphorylation GO:0007252 9.65 TLR2 TLR4 TLR9
45 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.65 TLR1 TLR2 TLR4 TLR6 TLR9
46 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.64 TLR2 TLR6
47 cellular response to triacyl bacterial lipopeptide GO:0071727 9.63 TLR1 TLR2
48 response to molecule of bacterial origin GO:0002237 9.63 CXCL8 TLR2 TLR9
49 nitric oxide metabolic process GO:0046209 9.62 TLR2 TLR6
50 positive regulation of oxidative stress-induced neuron death GO:1903223 9.62 TLR4 TLR6

Molecular functions related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.73 CXCL10 MBL2 TLR4 TLR6
2 signaling receptor activity GO:0038023 9.71 TLR1 TLR2 TLR4 TLR6
3 transmembrane signaling receptor activity GO:0004888 9.67 TLR1 TLR4 TLR6 TLR9
4 lipopolysaccharide binding GO:0001530 9.33 SFTPD TLR2 TLR4
5 lipopolysaccharide receptor activity GO:0001875 9.32 TLR2 TLR4
6 Toll-like receptor 2 binding GO:0035663 9.26 TLR1 TLR6
7 signaling pattern recognition receptor activity GO:0008329 9.13 CLEC7A TLR2 TLR9
8 lipopeptide binding GO:0071723 8.8 TLR1 TLR2 TLR6

Sources for Invasive Aspergillosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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