MCID: INV004
MIFTS: 37

Invasive Bladder Transitional Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Invasive Bladder Transitional Cell Carcinoma

MalaCards integrated aliases for Invasive Bladder Transitional Cell Carcinoma:

Name: Invasive Bladder Transitional Cell Carcinoma 12 15
Infiltrating Bladder Urothelial Carcinoma 73
Invasive Bladder Urothelial Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6477
NCIt 50 C27885
UMLS 73 C1334281

Summaries for Invasive Bladder Transitional Cell Carcinoma

MalaCards based summary : Invasive Bladder Transitional Cell Carcinoma, also known as infiltrating bladder urothelial carcinoma, is related to non-invasive bladder urothelial carcinoma and transitional cell carcinoma, and has symptoms including dysuria An important gene associated with Invasive Bladder Transitional Cell Carcinoma is NOTCH1 (Notch 1), and among its related pathways/superpathways are Pathways in cancer and Glioma. The drugs Cisplatin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and tongue, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Invasive Bladder Transitional Cell Carcinoma

Diseases related to Invasive Bladder Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 non-invasive bladder urothelial carcinoma 12.4
2 transitional cell carcinoma 10.4
3 bladder urothelial carcinoma 10.3
4 splenic diffuse red pulp small b-cell lymphoma 10.1 NOTCH1 TP53
5 spinal cord astrocytoma 10.1 NOTCH1 TP53
6 richter's syndrome 10.1 NOTCH1 TP53
7 supratentorial cancer 10.1 NOTCH1 TP53
8 cerebrum cancer 10.1 NOTCH1 TP53
9 actinic cheilitis 10.1 CDKN1A TP53
10 bladder transitional cell papilloma 10.1 CDKN1A TP53
11 atypical follicular adenoma 10.1 CDKN1A TP53
12 lip cancer 10.1 CDKN1A TP53
13 suppressor of tumorigenicity 3 10.1 CDKN1A TP53
14 malignant mesenchymoma 10.0 CDKN1A TP53
15 keratoacanthoma 10.0 CDKN1A TP53
16 retinal cancer 10.0 CDKN1A TP53
17 cervical adenocarcinoma 10.0 CDKN1A TP53
18 ocular cancer 10.0 CDKN1A TP53
19 prostate cancer 10.0
20 skin melanoma 10.0 CDKN1A TP53
21 anaplastic thyroid cancer 10.0 CDKN1A TP53
22 nervous system cancer 10.0 CDKN1A TP53
23 acute lymphocytic leukemia 10.0 NOTCH1 TP53
24 non-invasive bladder papillary urothelial neoplasm 10.0 TP53 UPK3A
25 li-fraumeni syndrome 10.0 CDKN1A TP53
26 vulvar disease 10.0 TP53 UPK3A
27 vulva cancer 9.9 TP53 UPK3A
28 tongue squamous cell carcinoma 9.9 NOTCH1 TP53
29 tongue cancer 9.9 CDKN1A NOTCH1 TP53
30 large intestine cancer 9.9 CDKN1A NOTCH1 TP53
31 brain cancer 9.9 CDKN1A NOTCH1 TP53
32 bladder disease 9.9 TP53 UPK3A
33 cervical cancer 9.9 CDKN1A NOTCH1 TP53
34 suppression of tumorigenicity 12 9.7 TP53 UPK3A
35 bladder cancer 9.7 CDKN1A TP53 UPK3A

Graphical network of the top 20 diseases related to Invasive Bladder Transitional Cell Carcinoma:



Diseases related to Invasive Bladder Transitional Cell Carcinoma

Symptoms & Phenotypes for Invasive Bladder Transitional Cell Carcinoma

UMLS symptoms related to Invasive Bladder Transitional Cell Carcinoma:


dysuria

GenomeRNAi Phenotypes related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.62 CDKN1A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.62 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.62 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.62 TP53
5 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.62 TP53
6 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.62 HOXA13
7 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.62 HOXA13
8 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.62 HOXA13 TP53
9 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.62 TP53
10 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.62 HOXA13
11 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.62 HOXA13
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.62 CDKN1A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.62 TP53
14 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.62 CDKN1A HOXA13 TP53
15 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.62 CDKN1A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.62 CDKN1A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.62 CDKN1A

MGI Mouse Phenotypes related to Invasive Bladder Transitional Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.26 CDKN1A HOXA13 NOTCH1 TP53
2 renal/urinary system MP:0005367 9.02 CDKN1A HOXA13 NOTCH1 TP53 UPK3A

Drugs & Therapeutics for Invasive Bladder Transitional Cell Carcinoma

Drugs for Invasive Bladder Transitional Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 1, Phase 2,Phase 2,Not Applicable 15663-27-1 2767 441203 84093
2
Methotrexate Approved Phase 1, Phase 2 59-05-2, 1959-05-2 126941
3
Vinblastine Approved Phase 1, Phase 2 865-21-4 241903 13342
4
Doxorubicin Approved, Investigational Phase 1, Phase 2 23214-92-8 31703
5
Gemcitabine Approved Phase 2,Not Applicable 95058-81-4 60750
6
Tremelimumab Investigational Phase 1, Phase 2 745013-59-6
7
Doxil Approved June 1999 Phase 1, Phase 2 31703
8 Antibodies, Monoclonal Phase 1, Phase 2
9 Immunoglobulins Phase 1, Phase 2
10 Antibodies Phase 1, Phase 2
11 Immunologic Factors Phase 1, Phase 2,Phase 2,Not Applicable
12 Antimetabolites Phase 2,Not Applicable
13 Antiviral Agents Phase 2,Not Applicable
14 Antimetabolites, Antineoplastic Phase 2,Not Applicable
15 Immunosuppressive Agents Phase 2,Not Applicable
16 Anti-Infective Agents Phase 2,Not Applicable
17
Nivolumab Approved Phase 1 946414-94-4
18
Altretamine Approved Phase 1 645-05-6 2123
19 Immunoglobulin G Phase 1

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 NEoadjuvant Dose-dense MVAC In cOmbination With Durvalumab and Tremelimumab in Muscle-invasive Urothelial Carcinoma Recruiting NCT03549715 Phase 1, Phase 2 Durvalumab;Tremelimumab;MVAC Protocol
2 Bristol Bladder Trial Recruiting NCT01616875 Phase 2 Cabazitaxel + Cisplatin chemotherapy
3 A Phase II Trial Evaluating an Organ-conserving Strategy by Radiochemotherapy for Muscle-infiltrative Bladder Cancer Recruiting NCT01495676 Phase 2
4 Gemcitabine Hydrochloride and Cisplatin in Treating Participants With Invasive Bladder Urothelial Cancer Recruiting NCT03609216 Phase 2 Gemcitabine Hydrochloride;Cisplatin
5 Pemetrexed and Avelumab in Treating Patients With MTAP-Deficient Metastatic Urothelial Cancer Not yet recruiting NCT03744793 Phase 2 Avelumab;Pemetrexed
6 Radiation Therapy and Pembrolizumab in Treating Patients With Localized Urothelial Bladder Cancer Withdrawn NCT03419130 Phase 2
7 Durvalumab and Tremelimumab in Treating Patients With Muscle-Invasive, High-Risk Urothelial Cancer That Cannot Be Treated With Cisplatin-Based Therapy Before Surgery Recruiting NCT02812420 Phase 1
8 Cabozantinib-s-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors Recruiting NCT02496208 Phase 1 Cabozantinib S-malate
9 sEphB4-HSA Before Surgery in Treating Patients With Bladder Cancer, Prostate Cancer, or Kidney Cancer Recruiting NCT02767921 Phase 1
10 Talimogene Laherparepvec in Treating Patients With Non-Muscle Invasive Bladder Transitional Cell Carcinoma Withdrawn NCT03430687 Phase 1
11 Quality of Life After Bladder-Preservation Chemotherapy and Radiation Therapy in Patients With Muscle-Invasive Bladder Cancer Recruiting NCT02688348 Not Applicable
12 Robot-Assisted Laparoscopic High-Intensity Focused Ultrasound and Radical Cystectomy for Thermal Ablation of Muscle Invasive Cells in Patients With Bladder Tumors Withdrawn NCT03238664 Not Applicable
13 Gemcitabine Hydrochloride, Cisplatin, and AGS-003-BLD in Treating Patients With Muscle-Invasive Bladder Cancer Undergoing Surgery Withdrawn NCT02944357 Not Applicable Cisplatin;Gemcitabine Hydrochloride

Search NIH Clinical Center for Invasive Bladder Transitional Cell Carcinoma

Genetic Tests for Invasive Bladder Transitional Cell Carcinoma

Anatomical Context for Invasive Bladder Transitional Cell Carcinoma

MalaCards organs/tissues related to Invasive Bladder Transitional Cell Carcinoma:

41
Skin, Brain, Tongue, Spinal Cord, Prostate, Thyroid, B Cells

Publications for Invasive Bladder Transitional Cell Carcinoma

Articles related to Invasive Bladder Transitional Cell Carcinoma:

# Title Authors Year
1
Detection of specific chromosomal aberrations in urine using BCA-1 (oligo-CGH-array) enhances diagnostic sensitivity and predicts the aggressiveness of non-muscle-invasive bladder transitional cell carcinoma. ( 24196429 )
2013
2
Parallel proteomic analysis in muscle-invasive bladder transitional cell carcinoma and cancer-related stroma. ( 23479173 )
2013
3
Overexpression of RING box protein-1 (RBX1) associated with poor prognosis of non-muscle-invasive bladder transitional cell carcinoma. ( 23609182 )
2013
4
[Expression analysis of NOTCH1/HES1/PTEN signaling pathway in invasive bladder transitional cell carcinoma]. ( 22781569 )
2012
5
Proteomics research on muscle-invasive bladder transitional cell carcinoma. ( 21645413 )
2011
6
Predictive value of cell cycle biomarkers in nonmuscle invasive bladder transitional cell carcinoma. ( 17222615 )
2007
7
Efficacy and tolerability of concurrent weekly low dose cisplatin during radiation treatment of localised muscle invasive bladder transitional cell carcinoma: a report of two sequential Phase II studies from the Trans Tasman Radiation Oncology Group. ( 17011058 )
2006
8
Structural alteration of p53 protein in patients with muscle invasive bladder transitional cell carcinoma. ( 11696726 )
2001

Variations for Invasive Bladder Transitional Cell Carcinoma

Expression for Invasive Bladder Transitional Cell Carcinoma

Search GEO for disease gene expression data for Invasive Bladder Transitional Cell Carcinoma.

Pathways for Invasive Bladder Transitional Cell Carcinoma

Pathways related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1 12.48 CDKN1A NOTCH1 TP53
2
Show member pathways
12.39 CDKN1A NOTCH1 TP53
3
Show member pathways
12.38 CDKN1A NOTCH1 TP53
4 12.02 CDKN1A NOTCH1 TP53
5 11.57 CDKN1A TP53
6 11.54 CDKN1A TP53
7
Show member pathways
11.53 CDKN1A TP53
8 11.49 CDKN1A TP53
9 11.44 CDKN1A NOTCH1
10 11.42 CDKN1A TP53
11 11.34 NOTCH1 TP53
12 11.22 CDKN1A TP53
13 11.2 CDKN1A TP53
14 11.18 CDKN1A TP53
15 11.12 CDKN1A TP53
16 11.08 CDKN1A TP53
17 11 CDKN1A TP53
18 10.83 CDKN1A TP53
19 10.66 CDKN1A TP53 UPK3A
20
Show member pathways
10.6 CDKN1A TP53
21 10.23 CDKN1A TP53
22
Show member pathways
9.86 CDKN1A TP53

GO Terms for Invasive Bladder Transitional Cell Carcinoma

Cellular components related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 8.92 NOTCH1 TP53 TPBG UPK3A

Biological processes related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.63 CDKN1A NOTCH1 TP53
2 Ras protein signal transduction GO:0007265 9.48 CDKN1A TP53
3 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.43 CDKN1A TP53
4 animal organ regeneration GO:0031100 9.4 CDKN1A NOTCH1
5 cellular response to ionizing radiation GO:0071479 9.37 CDKN1A TP53
6 intrinsic apoptotic signaling pathway GO:0097193 9.32 CDKN1A TP53
7 positive regulation of reactive oxygen species metabolic process GO:2000379 9.26 CDKN1A TP53
8 replicative senescence GO:0090399 9.16 CDKN1A TP53
9 cell cycle arrest GO:0007050 9.13 CDKN1A NOTCH1 TP53
10 signal transduction by p53 class mediator GO:0072331 8.62 CDKN1A TP53

Sources for Invasive Bladder Transitional Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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