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MCID: INV004
MIFTS: 37

Invasive Bladder Transitional Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Invasive Bladder Transitional Cell Carcinoma

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MalaCards integrated aliases for Invasive Bladder Transitional Cell Carcinoma:

Name: Invasive Bladder Transitional Cell Carcinoma 12 15
Infiltrating Bladder Urothelial Carcinoma 73
Invasive Bladder Urothelial Carcinoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6477
NCIt 50 C27885
UMLS 73 C1334281
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Summaries for Invasive Bladder Transitional Cell Carcinoma

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MalaCards based summary : Invasive Bladder Transitional Cell Carcinoma, also known as infiltrating bladder urothelial carcinoma, is related to transitional cell carcinoma and non-invasive bladder urothelial carcinoma, and has symptoms including dysuria An important gene associated with Invasive Bladder Transitional Cell Carcinoma is NOTCH1 (Notch 1), and among its related pathways/superpathways are Pathways in cancer and Glioma. The drugs Gemcitabine and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, prostate and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Invasive Bladder Transitional Cell Carcinoma

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Diseases related to Invasive Bladder Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 transitional cell carcinoma 29.6 TP53 UPK3A
2 non-invasive bladder urothelial carcinoma 12.3
3 splenic diffuse red pulp small b-cell lymphoma 10.4 NOTCH1 TP53
4 tetraploidy 10.4 NOTCH1 TP53
5 bone squamous cell carcinoma 10.3 NOTCH1 TP53
6 schneiderian carcinoma 10.3 NOTCH1 TP53
7 spinal cord astrocytoma 10.3 NOTCH1 TP53
8 richter's syndrome 10.3 NOTCH1 TP53
9 brain glioma 10.3 NOTCH1 TP53
10 non-invasive bladder papillary urothelial neoplasm 10.2 TP53 UPK3A
11 actinic cheilitis 10.2 CDKN1A TP53
12 bladder transitional cell papilloma 10.2 CDKN1A TP53
13 atypical follicular adenoma 10.2 CDKN1A TP53
14 suppressor of tumorigenicity 3 10.2 CDKN1A TP53
15 vulva cancer 10.2 TP53 UPK3A
16 malignant mesenchymoma 10.1 CDKN1A TP53
17 keratoacanthoma 10.1 CDKN1A TP53
18 retinal cancer 10.1 CDKN1A TP53
19 sensory system cancer 10.1 CDKN1A TP53
20 tongue cancer 10.1 CDKN1A TP53
21 anaplastic thyroid cancer 10.1 CDKN1A TP53
22 bladder urothelial carcinoma 10.1
23 cervical adenocarcinoma 10.0 CDKN1A TP53
24 ocular cancer 10.0 CDKN1A TP53
25 cystitis 10.0 TP53 UPK3A
26 nervous system cancer 10.0 CDKN1A TP53
27 acute lymphocytic leukemia 9.9 NOTCH1 TP53
28 prostate cancer 9.9
29 prostatitis 9.9
30 li-fraumeni syndrome 9.9 CDKN1A TP53
31 brain cancer 9.7 CDKN1A NOTCH1 TP53
32 gastrointestinal system cancer 9.7 CDKN1A TP53
33 cervical cancer 9.7 CDKN1A NOTCH1 TP53
34 bladder cancer 9.3 CDKN1A TP53 UPK3A

Graphical network of the top 20 diseases related to Invasive Bladder Transitional Cell Carcinoma:



Diseases related to Invasive Bladder Transitional Cell Carcinoma
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Symptoms & Phenotypes for Invasive Bladder Transitional Cell Carcinoma

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UMLS symptoms related to Invasive Bladder Transitional Cell Carcinoma:


dysuria

GenomeRNAi Phenotypes related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.62 CDKN1A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.62 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.62 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.62 TP53
5 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.62 TP53
6 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.62 HOXA13
7 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.62 HOXA13
8 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.62 TP53 HOXA13
9 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.62 TP53
10 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.62 HOXA13
11 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.62 HOXA13
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.62 CDKN1A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.62 TP53
14 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.62 TP53 CDKN1A HOXA13
15 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.62 CDKN1A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.62 CDKN1A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.62 CDKN1A

MGI Mouse Phenotypes related to Invasive Bladder Transitional Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.26 CDKN1A HOXA13 NOTCH1 TP53
2 renal/urinary system MP:0005367 9.02 CDKN1A HOXA13 NOTCH1 TP53 UPK3A
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Drugs & Therapeutics for Invasive Bladder Transitional Cell Carcinoma

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Drugs for Invasive Bladder Transitional Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 3,Phase 2,Not Applicable 95058-81-4 60750
2
Cisplatin Approved Phase 3,Phase 2,Not Applicable 15663-27-1 84093 441203 2767
3
Bevacizumab Approved, Investigational Phase 3 216974-75-3
4 Immunosuppressive Agents Phase 3,Phase 2,Not Applicable
5 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
6 Antimetabolites Phase 3,Phase 2,Not Applicable
7 Antiviral Agents Phase 3,Phase 2,Not Applicable
8 Antimetabolites, Antineoplastic Phase 3,Phase 2,Not Applicable
9 Mitogens Phase 3
10 Angiogenesis Inhibitors Phase 3
11 Angiogenesis Modulating Agents Phase 3
12 Endothelial Growth Factors Phase 3
13 Immunoglobulin G Phase 3
14 Antibodies Phase 3
15 Immunoglobulins Phase 3
16 Antibodies, Monoclonal Phase 3
17
Pembrolizumab Approved Phase 2 1374853-91-4
18
Altretamine Approved Phase 1 645-05-6 2123

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer Active, not recruiting NCT00942331 Phase 3 Cisplatin;Gemcitabine Hydrochloride
2 Bristol Bladder Trial Recruiting NCT01616875 Phase 2 Cabazitaxel + Cisplatin chemotherapy
3 A Phase II Trial Evaluating an Organ-conserving Strategy by Radiochemotherapy for Muscle-infiltrative Bladder Cancer Recruiting NCT01495676 Phase 2
4 NEoadjuvant Dose-dense MVAC In cOmbination With Durvalumab and Tremelimumab in Muscle-invasive Urothelial Carcinoma Not yet recruiting NCT03549715 Phase 1, Phase 2 Durvalumab;Tremelimumab;MVAC Protocol
5 Radiation Therapy and Pembrolizumab in Treating Patients With Localized Urothelial Bladder Cancer Not yet recruiting NCT03419130 Phase 2
6 sEphB4-HSA Before Surgery in Treating Patients With Bladder Cancer, Prostate Cancer, or Kidney Cancer Recruiting NCT02767921 Phase 1
7 Talimogene Laherparepvec in Treating Patients With Non-Muscle Invasive Bladder Transitional Cell Carcinoma Withdrawn NCT03430687 Phase 1
8 Quality of Life After Bladder-Preservation Chemotherapy and Radiation Therapy in Patients With Muscle-Invasive Bladder Cancer Recruiting NCT02688348 Not Applicable
9 Robot-Assisted Laparoscopic High-Intensity Focused Ultrasound and Radical Cystectomy for Thermal Ablation of Muscle Invasive Cells in Patients With Bladder Tumors Withdrawn NCT03238664 Not Applicable
10 Gemcitabine Hydrochloride, Cisplatin, and AGS-003-BLD in Treating Patients With Muscle-Invasive Bladder Cancer Undergoing Surgery Withdrawn NCT02944357 Not Applicable Cisplatin;Gemcitabine Hydrochloride

Search NIH Clinical Center for Invasive Bladder Transitional Cell Carcinoma

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Genetic Tests for Invasive Bladder Transitional Cell Carcinoma

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Anatomical Context for Invasive Bladder Transitional Cell Carcinoma

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MalaCards organs/tissues related to Invasive Bladder Transitional Cell Carcinoma:

41
Endothelial, Prostate, Kidney
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Publications for Invasive Bladder Transitional Cell Carcinoma

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Articles related to Invasive Bladder Transitional Cell Carcinoma:

# Title Authors Year
1
Detection of specific chromosomal aberrations in urine using BCA-1 (oligo-CGH-array) enhances diagnostic sensitivity and predicts the aggressiveness of non-muscle-invasive bladder transitional cell carcinoma. ( 24196429 )
2013
2
Parallel proteomic analysis in muscle-invasive bladder transitional cell carcinoma and cancer-related stroma. ( 23479173 )
2013
3
Overexpression of RING box protein-1 (RBX1) associated with poor prognosis of non-muscle-invasive bladder transitional cell carcinoma. ( 23609182 )
2013
4
[Expression analysis of NOTCH1/HES1/PTEN signaling pathway in invasive bladder transitional cell carcinoma]. ( 22781569 )
2012
5
Proteomics research on muscle-invasive bladder transitional cell carcinoma. ( 21645413 )
2011
6
Predictive value of cell cycle biomarkers in nonmuscle invasive bladder transitional cell carcinoma. ( 17222615 )
2007
7
Efficacy and tolerability of concurrent weekly low dose cisplatin during radiation treatment of localised muscle invasive bladder transitional cell carcinoma: a report of two sequential Phase II studies from the Trans Tasman Radiation Oncology Group. ( 17011058 )
2006
8
Structural alteration of p53 protein in patients with muscle invasive bladder transitional cell carcinoma. ( 11696726 )
2001
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Variations for Invasive Bladder Transitional Cell Carcinoma

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Expression for Invasive Bladder Transitional Cell Carcinoma

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Search GEO for disease gene expression data for Invasive Bladder Transitional Cell Carcinoma.
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Pathways for Invasive Bladder Transitional Cell Carcinoma

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Pathways related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Pathways in cancer 37
12.48 CDKN1A NOTCH1 TP53
2
Glioma 37
Show member pathways
 12.39 CDKN1A NOTCH1 TP53
3
Gastric cancer 37
Show member pathways
 12.38 CDKN1A NOTCH1 TP53
4
MicroRNAs in cancer 37
12.02 CDKN1A NOTCH1 TP53
5
Small cell lung cancer 37
11.57 CDKN1A TP53
6
Retinoblastoma (RB) in Cancer 1
11.54 CDKN1A TP53
7
ATM Pathway 64
Show member pathways
 11.53 CDKN1A TP53
8
Glucocorticoid receptor regulatory network 1
11.49 CDKN1A TP53
9
Primary Focal Segmental Glomerulosclerosis FSGS 1
11.44 CDKN1A NOTCH1
10
Platinum drug resistance 37
11.42 CDKN1A TP53
11
Pathways Affected in Adenoid Cystic Carcinoma 1
11.34 NOTCH1 TP53
12
Hepatitis C and Hepatocellular Carcinoma 1
11.22 CDKN1A TP53
13
Photodynamic therapy-induced AP-1 survival signaling. 1
11.2 CDKN1A TP53
14
miRNAs involved in DNA damage response 1
11.18 CDKN1A TP53
15
Integrated Cancer Pathway 1
11.12 CDKN1A TP53
16
DNA damage_ATM/ATR regulation of G1/S checkpoint 22
11.08 CDKN1A TP53
17
Signaling events mediated by HDAC Class III 1
11 CDKN1A TP53
18
GADD45 Pathway 64
10.83 CDKN1A TP53
19
Bladder cancer 37 1
10.66 CDKN1A TP53 UPK3A
20
TP53 Network 1
Show member pathways
 10.6 CDKN1A TP53
21
LncRNA-mediated mechanisms of therapeutic resistance 1
10.23 CDKN1A TP53
22
Transcriptional activation of cell cycle inhibitor p21 66
Show member pathways
 9.86 CDKN1A TP53
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GO Terms for Invasive Bladder Transitional Cell Carcinoma

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Cellular components related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 8.92 NOTCH1 TP53 TPBG UPK3A

Biological processes related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.7 CDKN1A NOTCH1 TP53
2 Ras protein signal transduction GO:0007265 9.54 CDKN1A TP53
3 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.51 CDKN1A TP53
4 animal organ regeneration GO:0031100 9.49 CDKN1A NOTCH1
5 cellular response to ionizing radiation GO:0071479 9.48 CDKN1A TP53
6 intrinsic apoptotic signaling pathway GO:0097193 9.46 CDKN1A TP53
7 positive regulation of reactive oxygen species metabolic process GO:2000379 9.43 CDKN1A TP53
8 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.4 CDKN1A TP53
9 cellular response to gamma radiation GO:0071480 9.37 CDKN1A TP53
10 response to X-ray GO:0010165 9.32 CDKN1A TP53
11 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.26 CDKN1A TP53
12 replicative senescence GO:0090399 9.16 CDKN1A TP53
13 cell cycle arrest GO:0007050 9.13 CDKN1A NOTCH1 TP53
14 signal transduction by p53 class mediator GO:0072331 8.62 CDKN1A TP53
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Sources for Invasive Bladder Transitional Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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