MCID: INV003
MIFTS: 32

Invasive Malignant Thymoma

Categories: Cancer diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Invasive Malignant Thymoma

MalaCards integrated aliases for Invasive Malignant Thymoma:

Name: Invasive Malignant Thymoma 12 15
Invasive Thymoma and Thymic Carcinoma 71
Thymoma Malignant Invasive 12
Infiltrating Thymoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3283
NCIt 49 C6453
UMLS 71 C0278846

Summaries for Invasive Malignant Thymoma

MalaCards based summary : Invasive Malignant Thymoma, also known as invasive thymoma and thymic carcinoma, is related to thymoma and b cell prolymphocytic leukemia. An important gene associated with Invasive Malignant Thymoma is PTMA (Prothymosin Alpha), and among its related pathways/superpathways are NF-kappaB Signaling and Cell adhesion molecules (CAMs). The drugs Prednisone and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include b cells, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Invasive Malignant Thymoma

Diseases in the Thymoma family:

Thymoma, Familial Invasive Malignant Thymoma
Type C Thymoma Malignant Type Ab Thymoma
Malignant Type a Thymoma Thymoma Type a
Thymoma Type B Thymoma Type Ab

Diseases related to Invasive Malignant Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 224)
# Related Disease Score Top Affiliating Genes
1 thymoma 30.8 TMSB4X PTMA CD8A
2 b cell prolymphocytic leukemia 10.4 CD38 CD19
3 refractory hematologic cancer 10.4 CD38 CD19
4 mental retardation, autosomal dominant 36 10.4 CD38 CD19
5 adult lymphoma 10.4 MME CD19
6 mental retardation, autosomal dominant 33 10.4 MME CD38
7 thymoma, familial 10.3
8 thymic carcinoma 10.3
9 lobomycosis 10.3 CD4 CD19
10 waldenstroem's macroglobulinemia 10.3 CD38 CD19
11 eye lymphoma 10.3 CD4 CD19
12 cerebral lymphoma 10.3 CD4 CD19
13 polyclonal hypergammaglobulinemia 10.2 MME CD4
14 cork-handlers' disease 10.2 CD8A CD4
15 vaginal cancer 10.2 MME CD4
16 spleen cancer 10.2 MME CD19
17 ventilation pneumonitis 10.2 CD8A CD4
18 diffuse infiltrative lymphocytosis syndrome 10.2 CD8A CD4
19 diabetes mellitus, insulin-dependent, 23 10.2 CD8A CD4
20 autoimmune lymphoproliferative syndrome, type iia 10.2 CD8A CD4
21 early yaws 10.2 CD8A CD4
22 parapsoriasis 10.2 CD8A CD4
23 norwegian scabies 10.2 CD8A CD4
24 cll/sll 10.2 MME CD38 CD19
25 skin sarcoidosis 10.2 CD8A CD4
26 mulchandani-bhoj-conlin syndrome 10.2 MME CD38 CD19
27 variola major 10.2 CD8A CD4
28 follicular mucinosis 10.2 CD8A CD4
29 viral exanthem 10.2 CD8A CD4
30 tertiary syphilis 10.2 CD8A CD4
31 spongiotic dermatitis 10.2 CD8A CD4
32 acute retinal necrosis syndrome 10.2 CD8A CD4
33 metal allergy 10.2 CD8A CD4
34 plasma cell neoplasm 10.2 MME CD38 CD19
35 cerebritis 10.2 CD8A CD4
36 marginal zone b-cell lymphoma 10.2 MME CD38 CD19
37 granulomatous hepatitis 10.2 CD8A CD4
38 acute interstitial pneumonia 10.2 CD8A CD4
39 west nile encephalitis 10.2 CD8A CD4
40 oral hairy leukoplakia 10.2 CD8A CD4
41 superficial basal cell carcinoma 10.2 CD8A CD4
42 secondary syphilis 10.2 CD8A CD4
43 glanders 10.2 CD8A CD4
44 nickel allergic contact dermatitis 10.2 CD8A CD4
45 west nile fever 10.2 CD8A CD4
46 neurosarcoidosis 10.2 CD8A CD4
47 esophageal candidiasis 10.2 CD8A CD4
48 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.2 CD8A CD4
49 cardiomyopathy, familial hypertrophic, 9 10.2 CD8A CD4
50 oral tuberculosis 10.2 CD8A CD4

Graphical network of the top 20 diseases related to Invasive Malignant Thymoma:



Diseases related to Invasive Malignant Thymoma

Symptoms & Phenotypes for Invasive Malignant Thymoma

MGI Mouse Phenotypes related to Invasive Malignant Thymoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.96 CD19 CD34 CD38 CD4 CD8A MME
2 endocrine/exocrine gland MP:0005379 9.7 CD38 CD4 CD8A PTH PTHLH TNFRSF25
3 hematopoietic system MP:0005397 9.61 CD19 CD34 CD38 CD4 CD8A PTH
4 immune system MP:0005387 9.32 CD19 CD34 CD38 CD4 CD8A MME

Drugs & Therapeutics for Invasive Malignant Thymoma

Drugs for Invasive Malignant Thymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
2
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
3
Saracatinib Investigational Phase 2 379231-04-6
4 Gastrointestinal Agents Phase 2
5 Hormones Phase 2
6 Antineoplastic Agents, Hormonal Phase 2
7 Hormone Antagonists Phase 2
8 glucocorticoids Phase 2
9 Anti-Inflammatory Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Octreotide Treatment of Advanced, Recurrent Thymoma Completed NCT00003283 Phase 2 octreotide acetate;prednisone
2 Phase II Trial of AZD0530 for Patients With Relapsed/Refractory Thymic Malignancies (Thymoma and Thymic Carcinoma) Terminated NCT00718809 Phase 2 saracatinib

Search NIH Clinical Center for Invasive Malignant Thymoma

Genetic Tests for Invasive Malignant Thymoma

Anatomical Context for Invasive Malignant Thymoma

MalaCards organs/tissues related to Invasive Malignant Thymoma:

40
B Cells

Publications for Invasive Malignant Thymoma

Articles related to Invasive Malignant Thymoma:

(show all 13)
# Title Authors PMID Year
1
En-bloc thymectomy with aortic arch reconstruction under circulatory arrest for invasive malignant thymoma. 61
32353149 2020
2
Myasthenia gravis associated with invasive malignant thymoma: two case reports and a review of the literature. 61
25312448 2014
3
[Irradiation for invasive malignant thymoma led a remission of refractory minimal change nephrotic syndrome: a case report]. 61
20560473 2010
4
Imaging of an invasive malignant thymoma on PET Scan: CT and histopathologic correlation. 61
16985366 2006
5
Association of a wide invasive malignant thymoma with myastenia gravis and primary hyperparathyroidism due to parathyroid adenoma: case report and review of the literature. 61
16873103 2006
6
Incidental locally infiltrating malignant thymoma and coronary artery bypass surgery-excision should always be considered. 61
15854100 2005
7
Severe T- and B-cell immune deficiency associated with malignant thymoma. 61
14692437 2003
8
Thymoma--report of 71 cases and a review. 61
1571088 1992
9
Biochemical characterization of thymic hormones in thymoma tissues. 61
2333664 1990
10
Undifferentiated epithelial-rich invasive malignant thymoma: complete response to cisplatin, vinblastine, and bleomycin therapy. 61
2450971 1988
11
Aggressive surgical approach for drug-free remission from myasthenia gravis. 61
3579398 1987
12
Cardiovascular involvement by invasive thymomas. 61
865126 1977
13
[On the treatment of invasive malignant thymoma]. 61
5692541 1968

Variations for Invasive Malignant Thymoma

Expression for Invasive Malignant Thymoma

Search GEO for disease gene expression data for Invasive Malignant Thymoma.

Pathways for Invasive Malignant Thymoma

GO Terms for Invasive Malignant Thymoma

Cellular components related to Invasive Malignant Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 CD8A CD4 CD34 CD19
2 cell surface GO:0009986 9.35 TSHR MME CD4 CD38 CD34
3 integral component of plasma membrane GO:0005887 9.17 TSHR TNFRSF25 MME CD8A CD4 CD34

Biological processes related to Invasive Malignant Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.7 TSHR TNFRSF25 PTHLH GNAT3 CD4 CD38
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.43 TSHR PTHLH PTH
3 negative regulation of chondrocyte differentiation GO:0032331 9.37 PTHLH PTH
4 response to vitamin D GO:0033280 9.32 PTH CD4
5 cell surface receptor signaling pathway GO:0007166 9.26 TSHR TNFRSF25 CD8A CD4
6 cAMP metabolic process GO:0046058 8.62 PTHLH PTH

Molecular functions related to Invasive Malignant Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.62 PTHLH PTH

Sources for Invasive Malignant Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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