MCID: INV003
MIFTS: 34

Invasive Malignant Thymoma

Categories: Cancer diseases, Endocrine diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Invasive Malignant Thymoma

MalaCards integrated aliases for Invasive Malignant Thymoma:

Name: Invasive Malignant Thymoma 12 15
Invasive Thymoma and Thymic Carcinoma 73
Thymoma Malignant Invasive 12
Infiltrating Thymoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3283
NCIt 50 C6453 C7904
UMLS 73 C0278846

Summaries for Invasive Malignant Thymoma

MalaCards based summary : Invasive Malignant Thymoma, also known as invasive thymoma and thymic carcinoma, is related to parathyroid adenoma and primary hyperparathyroidism. An important gene associated with Invasive Malignant Thymoma is CD19 (CD19 Molecule), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Prednisone and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include skin, b cells and myeloid, and related phenotype is immune system.

Related Diseases for Invasive Malignant Thymoma

Diseases in the Thymoma family:

Thymoma, Familial Invasive Malignant Thymoma
Type C Thymoma Malignant Type Ab Thymoma
Malignant Type a Thymoma Thymoma Type a
Thymoma Type B Thymoma Type Ab

Diseases related to Invasive Malignant Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 parathyroid adenoma 29.8 PTH PTHLH
2 primary hyperparathyroidism 29.6 PTH PTHLH
3 b cell prolymphocytic leukemia 10.2 CD19 CD38
4 prolymphocytic leukemia 10.2 CD19 CD38
5 thymoma 10.2
6 waldenstroem's macroglobulinemia 10.2 CD19 CD38
7 non-secretory myeloma 10.2 CD19 CD38
8 gamma heavy chain disease 10.2 CD19 CD38
9 central nervous system leukemia 10.2 CD19 MME
10 solitary osseous plasmacytoma 10.2 CD19 CD38
11 bladder lymphoma 10.1 CD19 MME
12 diffuse infiltrative lymphocytosis syndrome 10.1 CD19 CD38
13 plasma cell neoplasm 10.1 CD19 CD38
14 encapsulated thymoma 10.1 CD38 MME
15 monoclonal gammopathy of uncertain significance 10.1 CD19 CD38
16 extraskeletal chondroma 10.1 PTH PTHLH
17 sclerosing hepatic carcinoma 10.1 PTH PTHLH
18 hypocalciuric hypercalcemia, familial, type iii 10.1 PTH PTHLH
19 clear cell adenoma 10.1 PTH PTHLH
20 oncogenic osteomalacia 10.1 PTH PTHLH
21 hypercalcemia, infantile, 1 10.1 PTH PTHLH
22 cll/sll 10.1 CD38 MME
23 angiomyoma 10.1 CD34 PTHLH
24 lymphatic system cancer 10.1 CD19 MME
25 chorioangioma 10.1 CD34 PTHLH
26 breast myofibroblastoma 10.1 CD34 MME
27 hemangioma of intra-abdominal structure 10.1 CD34 PTHLH
28 psammomatous meningioma 10.1 CD34 MME
29 cloacogenic carcinoma 10.1 PTH PTHLH
30 metaphyseal chondrodysplasia, jansen type 10.1 PTH PTHLH
31 lymphoma, hodgkin, classic 10.1 CD19 MME
32 tibial adamantinoma 10.1 CD34 PTH
33 breast benign neoplasm 10.1 CD34 MME
34 parathyroid gland disease 10.1 PTH PTHLH
35 thoracic benign neoplasm 10.1 CD34 MME
36 sarcomatoid squamous cell skin carcinoma 10.1 CD34 MME
37 pseudohypoparathyroidism 10.1 PTH PTHLH
38 pseudohypoparathyroidism, type ib 10.1 PTH PTHLH
39 pediatric lymphoma 10.0 CD34 MME
40 hypoparathyroidism 10.0 PTH PTHLH
41 nephrogenic adenofibroma 10.0 CD34 MME
42 mineral metabolism disease 10.0 PTH PTHLH
43 leukemia, acute lymphoblastic 3 10.0 CD19 MME
44 lymphoma, mucosa-associated lymphoid type 10.0 CD19 MME
45 plasma protein metabolism disease 10.0 CD19 CD38 MME
46 mature b-cell neoplasm 10.0 CD19 CD38 MME
47 cell type benign neoplasm 10.0 CD34 PTH
48 acquired immunodeficiency syndrome 9.9 CD34 CD38
49 leiomyoma 9.9 CD34 MME
50 myasthenia gravis 9.9

Graphical network of the top 20 diseases related to Invasive Malignant Thymoma:



Diseases related to Invasive Malignant Thymoma

Symptoms & Phenotypes for Invasive Malignant Thymoma

MGI Mouse Phenotypes related to Invasive Malignant Thymoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.1 CD19 CD34 CD38 MME PTH PTHLH

Drugs & Therapeutics for Invasive Malignant Thymoma

Drugs for Invasive Malignant Thymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
2
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
3
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
4
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
5
Saracatinib Investigational Phase 2 379231-04-6
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
7 Antineoplastic Agents, Hormonal Phase 2
8 Anti-Inflammatory Agents Phase 2
9 Gastrointestinal Agents Phase 2
10 Hormone Antagonists Phase 2
11 glucocorticoids Phase 2
12 Hormones Phase 2
13 Antineoplastic Agents, Phytogenic Phase 2
14 Antimitotic Agents Phase 2
15 Albumin-Bound Paclitaxel Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Octreotide With or Without Prednisone in Treating Patients With Metastatic or Recurrent Thymoma Completed NCT00003283 Phase 2 octreotide acetate;prednisone
2 Paclitaxel and Cisplatin for Thymic Neoplasm Terminated NCT00818090 Phase 2 paclitaxel and cisplatin
3 Saracatinib in Treating Patients With Relapsed or Refractory Thymoma or Thymic Cancer Terminated NCT00718809 Phase 2 saracatinib

Search NIH Clinical Center for Invasive Malignant Thymoma

Genetic Tests for Invasive Malignant Thymoma

Anatomical Context for Invasive Malignant Thymoma

MalaCards organs/tissues related to Invasive Malignant Thymoma:

41
Skin, B Cells, Myeloid

Publications for Invasive Malignant Thymoma

Articles related to Invasive Malignant Thymoma:

# Title Authors Year
1
Myasthenia gravis associated with invasive malignant thymoma: two case reports and a review of the literature. ( 25312448 )
2014
2
Imaging of an invasive malignant thymoma on PET Scan: CT and histopathologic correlation. ( 16985366 )
2006
3
Association of a wide invasive malignant thymoma with myastenia gravis and primary hyperparathyroidism due to parathyroid adenoma: case report and review of the literature. ( 16873103 )
2006
4
Undifferentiated epithelial-rich invasive malignant thymoma: complete response to cisplatin, vinblastine, and bleomycin therapy. ( 2450971 )
1988

Variations for Invasive Malignant Thymoma

Expression for Invasive Malignant Thymoma

Search GEO for disease gene expression data for Invasive Malignant Thymoma.

Pathways for Invasive Malignant Thymoma

GO Terms for Invasive Malignant Thymoma

Biological processes related to Invasive Malignant Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bone mineralization GO:0030282 9.16 PTH PTHLH
2 negative regulation of chondrocyte differentiation GO:0032331 8.96 PTH PTHLH
3 cAMP metabolic process GO:0046058 8.62 PTH PTHLH

Molecular functions related to Invasive Malignant Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.62 PTH PTHLH

Sources for Invasive Malignant Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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