MCID: INV005
MIFTS: 26

Inverted Follicular Keratosis

Categories: Cancer diseases, Skin diseases
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Aliases & Classifications for Inverted Follicular Keratosis

MalaCards integrated aliases for Inverted Follicular Keratosis:

Name: Inverted Follicular Keratosis 11 14 16 71
Inverted Folicular Keratosis 11
Seborrheic Keratosis 71

Classifications:



External Ids:

Disease Ontology 11 DOID:6945
NCIt 49 C9007
SNOMED-CT 68 201096007
UMLS 71 C0022603 C0334019

Summaries for Inverted Follicular Keratosis

MalaCards based summary: Inverted Follicular Keratosis, also known as inverted folicular keratosis, is related to vulvar inverted follicular keratosis and keratosis. An important gene associated with Inverted Follicular Keratosis is PHLDA1 (Pleckstrin Homology Like Domain Family A Member 1), and among its related pathways/superpathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Platelet Adhesion to exposed collagen. The drugs Hydrogen peroxide and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin.

Related Diseases for Inverted Follicular Keratosis

Diseases related to Inverted Follicular Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 vulvar inverted follicular keratosis 11.7
2 keratosis 10.9
3 basal cell carcinoma 10.4
4 keratosis, seborrheic 10.3
5 basal cell carcinoma 1 10.3
6 common wart 10.3
7 melanoma 10.2
8 papilloma 10.2
9 muir-torre syndrome 10.1
10 cowden syndrome 1 10.1
11 thyroglossal duct cyst, familial 10.1
12 chronic apical periodontitis 10.1
13 acanthoma 10.1
14 squamous cell carcinoma 10.1
15 thyroid gland cancer 10.1
16 keratoacanthoma 10.1
17 skin benign neoplasm 10.1
18 skin carcinoma 10.1
19 amelanotic melanoma 10.1
20 eccrine acrospiroma 10.1
21 cowden syndrome 10.1
22 periapical periodontitis 10.1
23 periodontitis 10.1
24 pyogenic granuloma 10.1
25 trichofolliculoma 10.1
26 follicular infundibulum tumor 10.1 PHLDA1 KRT17
27 morpheaform basal cell carcinoma 10.1 PHLDA1 KRT17
28 basosquamous carcinoma 10.0 PTGER4 PHLDA1
29 squamous papillomatosis 10.0 PTGER4 PHLDA1
30 clear cell basal cell carcinoma 10.0 PHLDA1 KRT17
31 hair follicle neoplasm 10.0 PHLDA1 KRT17
32 large cell acanthoma 10.0 PTGER4 KRT17
33 comedo carcinoma 10.0 PTGER4 GP5
34 borst-jadassohn intraepidermal carcinoma 9.9 PTGER4 KRT17
35 middle ear squamous cell carcinoma 9.9 GP6 GP5
36 pilomatrixoma 9.9 PHLDA1 KRT17
37 focal epithelial hyperplasia 9.9 GP6 GP5
38 cervical adenosarcoma 9.9 GP6 GP5
39 chronic cervicitis 9.9 GP6 GP5
40 cervicitis 9.9 GP6 GP5
41 anus cancer 9.8 GP6 GP5
42 anogenital venereal wart 9.8 GP6 GP5
43 hidradenoma 9.8 PHLDA1 NUTM1
44 gray platelet syndrome 9.8 GP6 GP5
45 malignant syringoma 9.8 PTGER4 PHLDA1 KRT17
46 penile cancer 9.8 GP6 GP5
47 epidermodysplasia verruciformis 1 9.7 GP6 GP5
48 uterus carcinoma in situ 9.7 KRT17 GP6 GP5
49 cervix uteri carcinoma in situ 9.7 KRT17 GP6 GP5
50 bernard-soulier syndrome 9.7 GP6 GP5

Graphical network of the top 20 diseases related to Inverted Follicular Keratosis:



Diseases related to Inverted Follicular Keratosis

Symptoms & Phenotypes for Inverted Follicular Keratosis

Drugs & Therapeutics for Inverted Follicular Keratosis

Drugs for Inverted Follicular Keratosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
2 Pharmaceutical Solutions Phase 4
3
Fusidic acid Approved, Investigational 6990-06-3 3000226
4
Petrolatum Approved, Investigational 8009-03-8
5
Chlorhexidine Approved, Vet_approved, Withdrawn 55-56-1 2713 9552079
6 Anti-Bacterial Agents
7 Anti-Infective Agents
8 Emollients
9 Dermatologic Agents
10 Chlorhexidine gluconate

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 An Open-Label Study Assessing Subject Satisfaction With A-101 Hydrogen Peroxide Topical Solution, 40% (w/w) Treatment for Seborrheic Keratoses of the Face, Neck, and Decolletage Completed NCT03487588 Phase 4 A-101 Topical Solution
2 An Open-Label Study of the Safety of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face. Completed NCT02667288 Phase 3 A-101 Solution
3 A Randomized, Double-Blind, Vehicle-Controlled, PArallel Group Study of the Safety and Effectiveness of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face. Completed NCT02667275 Phase 3 A-101 Solution
4 A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Safety and Effectiveness of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face. Completed NCT02667236 Phase 3 A-101 Solution
5 A Randomized, Double-Blind, Vehicle-Controlled, Within-Subject, Comparison Study of the Safety, Tolerability, And Effectiveness of A-101 Topical Solution in Subjects With Seborrheic Keratosis Completed NCT01986920 Phase 1, Phase 2 A-101 25%;A-101 32.5%;A-101 40%;A-101 Vehicle
6 A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Dose-Response Profile of A-101 Topical Solution in Subjects With Seborrheic Keratosis of the Face Completed NCT02260180 Phase 2 A-101
7 A Phase 2 Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Safety and Effectiveness of A-101(Hydrogen Peroxide) Topical Solution in Subjects With Seborrheic Keratosis Lesions on the Trunk, Extremities, and Face Completed NCT03148691 Phase 2 A-101
8 A Randomized, Double-Blind, Vehicle Controlled, Parallel Group Study of the Dose-Response Profile of A-101 Topical Solution in Subjects With Seborrheic Keratosis. Completed NCT02160626 Phase 2 A-101 Vehicle;A-101 (40) Topical Solution;A-101 (32.5) Topical Solution
9 A Phase 2a, Multi-Centre, Open-Label Study to Evaluate the Safety and Efficacy of PEP005(Ingenol Mebutate) Gel, 0.05%, in Patients With Seborrhoeic Keratosis on Non-head Locations Completed NCT01214564 Phase 2 PEP005 (ingenol mebutate) Gel
10 Open Label Adaptive Design Study to Explore the Safety and Efficacy of Multiple Treatment Regimens With the Akt Inhibitor SM-020 in 1.0% and 0.1% Gel Formulations in Subjects With Seborrheic Keratosis Recruiting NCT05136144 Phase 2 SM-020
11 Fast Track Diagnosis of Skin Tumours by Four Different Advanced Imaging Technologies - a Clinical Study Unknown status NCT04229277
12 Prospective, Open-Label, Multi-Center, Non-Significant Risk Study of Nano-Pulse Stimulation™ (NPS™) Technology in Healthy Adults With Seborrheic Keratosis Completed NCT04249115
13 Evaluation of Nano-Pulse Stimulation (NPS) in Patients With Seborrheic Keratosis Completed NCT03846531
14 Optical Biopsy of Human Skin in Conjunction With Laser Treatment Completed NCT00540566
15 Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses? Completed NCT01159860
16 Effectiveness of Sodium Fusidate Ointment Compared to Petrolatum for Wound Healing Following Cauterization: A Double-Blind Randomized Controlled Trial Completed NCT05353374 Sodium Fusidate 2 % Topical Ointment;Petrolatum ointment
17 Comparative Study of Electrical Impedance Spectroscopy (EIS) Models Against Verified Dermatological Diagnostic Data Suspended NCT04688749

Search NIH Clinical Center for Inverted Follicular Keratosis

Genetic Tests for Inverted Follicular Keratosis

Anatomical Context for Inverted Follicular Keratosis

Organs/tissues related to Inverted Follicular Keratosis:

MalaCards : Skin

Publications for Inverted Follicular Keratosis

Articles related to Inverted Follicular Keratosis:

(show top 50) (show all 69)
# Title Authors PMID Year
1
Seborrheic Keratosis With Malignant Transformation (Invasive or Noninvasive Squamous Cell Carcinoma Arising in Seborrheic Keratosis): A Clinicopathologic and Immunohistochemical Study of 11 Cases. 62
36395445 2022
2
Two Distinct Lesions of Inverted Follicular Keratosis of the Scalp: A Case Report. 62
36349066 2022
3
Pigmented inverted follicular keratosis masquerading as basal cell carcinoma. 62
36304658 2022
4
A case of adnexal tumor combining inverted follicular keratosis and trichoblastoma: molecular genetics evidence against a pathogenetic role of human Papillomaviruses. 62
33890741 2022
5
Inverted follicular keratosis: dermoscopic features of 23 cases. 62
32129053 2021
6
Cutaneous Horn Overlying Inverted Follicular Keratosis: A Rare Case Report. 62
34430483 2021
7
A rare case of inverted follicular keratosis in an elderly male: Dermoscopic and histopathological overview with therapeutic response to imiquimod. 62
33943061 2021
8
Periocular inverted follicular keratosis: a retrospective series over 17 years. 62
30604112 2019
9
Giant Squamous Cell Papilloma of the Eyelid-Diagnostic and Therapeutic Challenges. 62
31781447 2019
10
Inverted Follicular Keratosis: Stand-Alone Entity or Variant. 62
31145057 2019
11
Composite trichoblastoma and inverted follicular keratosis: a case report. 62
31938412 2018
12
Reflectance confocal microscopy of an inverted follicular keratosis mimicking a squamous cell carcinoma. 62
29214108 2017
13
Cutaneous Horn of the Eyelid in 13 Cases. 62
27811637 2017
14
Dermoscopy of inverted follicular keratosis: study of 12 cases. 62
27018237 2016
15
Inverted follicular keratosis successfully treated with imiquimod. 62
27294052 2016
16
Pseudoepitheliomatous changes in a case of vegetating Darier–White disease: a unique histopathological finding. 62
25238450 2015
17
Rare case of external dental fistula of the submental region misdiagnosed as inverted follicular keratosis and thyroglossal duct cyst. 62
26413920 2015
18
Human Papillomavirus Deoxyribonucleic Acid may not be Detected in Non-genital Benign Papillomatous Skin Lesions by Polymerase Chain Reaction. 62
25071248 2014
19
Inverted follicular keratosis of the lip. 62
25469197 2014
20
Simulators of squamous cell carcinoma of the skin: diagnostic challenges on small biopsies and clinicopathological correlation. 62
23878739 2013
21
Inverted follicular keratosis: dermoscopic and reflectance confocal microscopic features. 62
23988627 2013
22
Pigmented tumor in the nostril. 62
24396720 2011
23
Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis. 62
19615018 2010
24
Inverted follicular keratosis with sebaceoma-like areas: first case report. 62
19638553 2009
25
Inverted follicular keratosis of the nasal vestibule. 62
19643268 2009
26
Are all seborrheic keratoses benign? Review of the typical lesion and its variants. 62
18845088 2008
27
[Immunohistochemical study of calretinin in normal hair follicles and tumors with follicular differentiation]. 62
18558053 2008
28
[Acral keratoses and inverted follicular keratosis presenting Cowden disease]. 62
17663933 2007
29
[Benign pigmented lesions of the eyelids]. 62
16249773 2005
30
Multiple inverted follicular keratoses as a presenting sign of Cowden's syndrome: case report with human papillomavirus studies. 62
15337985 2004
31
Conjunctival inverted follicular keratosis: a case report. 62
15486776 2004
32
Inverted follicular keratosis simulating malignant melanoma. 62
14961911 2004
33
[Benign hair-follicle derived eyelids tumors in adults]. 62
12410406 2002
34
Inverted follicular keratosis. 62
11411260 2001
35
Inverted follicular keratosis of the vulvar skin: a lesion that can be confused with squamous cell carcinoma. 62
11109167 2000
36
Verrucous cysts: histopathologic characterization and molecular detection of human papillomavirus-specific DNA. 62
8300926 1993
37
Inverted follicular keratosis. 62
8214316 1993
38
Inverted follicular keratosis and papillomavirus infection. 62
1851400 1991
39
[Histologic aspects of seborrheic keratosis]. 62
2145481 1990
40
Multiple infundibular tumours of the head and neck. 62
2757928 1989
41
Inverted follicular keratosis. A report of two recurrent cases. 62
3684220 1987
42
Squamous cell carcinoma of the eyelids. 62
3601369 1987
43
Inverted follicular keratosis. 62
2409255 1985
44
The cutaneous pathology of Cowden's disease: new findings. 62
2582011 1985
45
Inverted follicular keratosis of the lip. 62
6588345 1984
46
Inverted follicular keratosis and verruca vulgaris. An investigation for the papillomavirus common antigen. 62
6330188 1984
47
Inverted follicular keratosis and human papillomaviruses. 62
6318588 1983
48
Inverted follicular keratosis is an irritated seborrheic keratosis. 62
6229190 1983
49
Inverted follicular keratosis is not a specific keratosis but a verruca vulgaris (or seborrheic keratosis) with squamous eddies. 62
6229188 1983
50
Inverted follicular keratosis is a distinct follicular tumor. 62
6660428 1983

Variations for Inverted Follicular Keratosis

Expression for Inverted Follicular Keratosis

Search GEO for disease gene expression data for Inverted Follicular Keratosis.

Pathways for Inverted Follicular Keratosis

Pathways related to Inverted Follicular Keratosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 GP6 GP5
2
Show member pathways
10.05 GP6 GP5

GO Terms for Inverted Follicular Keratosis

Biological processes related to Inverted Follicular Keratosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.13 GP6 GP5
2 hemostasis GO:0007599 8.62 GP6 GP5

Sources for Inverted Follicular Keratosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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