MCID: INV005
MIFTS: 32

Inverted Follicular Keratosis

Categories: Skin diseases

Aliases & Classifications for Inverted Follicular Keratosis

MalaCards integrated aliases for Inverted Follicular Keratosis:

Name: Inverted Follicular Keratosis 12 15 17 71
Inverted Folicular Keratosis 12
Seborrheic Keratosis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:6945
NCIt 49 C9007
SNOMED-CT 67 15112009
UMLS 71 C0022603 C0334019

Summaries for Inverted Follicular Keratosis

MalaCards based summary : Inverted Follicular Keratosis, also known as inverted folicular keratosis, is related to keratosis, seborrheic and eccrine acrospiroma. An important gene associated with Inverted Follicular Keratosis is CLEC2A (C-Type Lectin Domain Family 2 Member A), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and ECM-receptor interaction. The drugs Hydrogen peroxide and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and eye.

Related Diseases for Inverted Follicular Keratosis

Diseases related to Inverted Follicular Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 keratosis, seborrheic 30.4 KRT17 CLEC2A
2 eccrine acrospiroma 30.2 KRT17 CLEC2A
3 vulvar inverted follicular keratosis 12.8
4 keratosis 10.9
5 squamous cell carcinoma 10.4
6 melanoma 10.3
7 basal cell carcinoma 10.3
8 papilloma 10.3
9 chronic apical periodontitis 10.1
10 squamous cell papilloma 10.1
11 clear cell acanthoma 10.1
12 acanthoma 10.1
13 thyroid gland cancer 10.1
14 keratoacanthoma 10.1
15 skin benign neoplasm 10.1
16 skin carcinoma 10.1
17 amelanotic melanoma 10.1
18 periodontitis 10.1
19 in situ carcinoma 10.1
20 pyogenic granuloma 10.1
21 trichofolliculoma 10.1
22 eccrine sweat gland neoplasm 10.0 KRT17 CLEC2A
23 hair follicle neoplasm 10.0 KRT17 CLEC2A
24 borst-jadassohn intraepidermal carcinoma 10.0 KRT17 CLEC2A
25 cervicitis 9.9 GP6 GP5
26 cervical adenosarcoma 9.9 GP6 GP5
27 focal epithelial hyperplasia 9.9 GP6 GP5
28 malignant acrospiroma 9.8 PHLDA1 CLEC2A
29 pilar sheath acanthoma 9.8 PHLDA1 CLEC2A
30 anus cancer 9.8 GP6 GP5
31 malignant syringoma 9.8 PHLDA1 CLEC2A
32 anogenital venereal wart 9.8 GP6 GP5
33 eccrine sweat gland cancer 9.8 PHLDA1 CLEC2A
34 sweat gland cancer 9.8 PHLDA1 CLEC2A
35 penile disease 9.8 GP6 GP5
36 herpangina 9.8 GP6 GP5
37 epidermal appendage tumor 9.8 PHLDA1 CLEC2A
38 oropharynx cancer 9.8 GP6 GP5
39 thrombocytopenic purpura, autoimmune 9.7 GP6 GP5
40 pre-malignant neoplasm 9.7 KRT17 GP5
41 epidermodysplasia verruciformis 1 9.7 GP6 GP5
42 gray platelet syndrome 9.6 GP6 GP5
43 anus disease 9.6 SALL1 GP6 GP5
44 rectal disease 9.6 SALL1 GP6 GP5
45 bernard-soulier syndrome 9.5 GP6 GP5
46 chronic cervicitis 9.5 KRT17 GP6 GP5
47 uterus carcinoma in situ 9.5 KRT17 GP6 GP5
48 cervix uteri carcinoma in situ 9.5 KRT17 GP6 GP5
49 follicular infundibulum tumor 9.5 PHLDA1 KRT17 CLEC2A
50 morpheaform basal cell carcinoma 9.5 PHLDA1 KRT17 CLEC2A

Graphical network of the top 20 diseases related to Inverted Follicular Keratosis:



Diseases related to Inverted Follicular Keratosis

Symptoms & Phenotypes for Inverted Follicular Keratosis

Drugs & Therapeutics for Inverted Follicular Keratosis

Drugs for Inverted Follicular Keratosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
2
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177 70789204
3
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
4
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
5 Immunologic Factors Phase 1, Phase 2
6 Antibiotics, Antitubercular Phase 1, Phase 2
7 Antifungal Agents Phase 1, Phase 2
8 Immunosuppressive Agents Phase 1, Phase 2
9 Anti-Bacterial Agents Phase 1, Phase 2
10 Anti-Infective Agents Phase 1, Phase 2
11
Glycolic acid Approved, Investigational 79-14-1 757
12 Pharmaceutical Solutions
13 Dermatologic Agents
14 Keratolytic Agents
15 Anesthetics

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 An Open-Label Study Assessing Subject Satisfaction With A-101 Hydrogen Peroxide Topical Solution, 40% (w/w) Treatment for Seborrheic Keratoses of the Face, Neck, and Decolletage Completed NCT03487588 Phase 4 A-101 Topical Solution
2 A Randomized, Double-Blind, Vehicle-Controlled, PArallel Group Study of the Safety and Effectiveness of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face. Completed NCT02667275 Phase 3 A-101 Solution
3 A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Safety and Effectiveness of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face. Completed NCT02667236 Phase 3 A-101 Solution
4 An Open-Label Study of the Safety of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face. Completed NCT02667288 Phase 3 A-101 Solution
5 Novel Compositions for Treating or Preventing Dermal Disorders Unknown status NCT03103893 Phase 1, Phase 2 Rapamycin
6 A Randomized, Double-Blind, Vehicle-Controlled, Within-Subject, Comparison Study of the Safety, Tolerability, And Effectiveness of A-101 Topical Solution in Subjects With Seborrheic Keratosis Completed NCT01986920 Phase 1, Phase 2 A-101 25%;A-101 32.5%;A-101 40%;A-101 Vehicle
7 A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Dose-Response Profile of A-101 Topical Solution in Subjects With Seborrheic Keratosis of the Face Completed NCT02260180 Phase 2 A-101
8 A Randomized, Double-Blind, Vehicle Controlled, Parallel Group Study of the Dose-Response Profile of A-101 Topical Solution in Subjects With Seborrheic Keratosis. Completed NCT02160626 Phase 2 A-101 Vehicle;A-101 (40) Topical Solution;A-101 (32.5) Topical Solution
9 A Phase 2 Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Safety and Effectiveness of A-101(Hydrogen Peroxide) Topical Solution in Subjects With Seborrheic Keratosis Lesions on the Trunk, Extremities, and Face Completed NCT03148691 Phase 2 A-101
10 A Phase 2a, Multi-Centre, Open-Label Study to Evaluate the Safety and Efficacy of PEP005(Ingenol Mebutate) Gel, 0.05%, in Patients With Seborrhoeic Keratosis on Non-head Locations Completed NCT01214564 Phase 2 PEP005 (ingenol mebutate) Gel
11 An Investigator-Initiated Study to Assess the Efficacy and Degree of Irritation of Ingenol Mebutate 0.015% Gel and Dermasil Lotion Versus Ingenol Mebuate 0.015% Alone in the Treatment of Actinic Keratoses (AK) on the Face. Completed NCT02411851 Phase 1 ingenol mebutate 0.015%
12 Improving Diagnosis of Skin Cancer Patients Via Optical Coherence Tomography and Teledermatology- A Pilot Study Unknown status NCT01680562
13 Evaluation of Nano-Pulse Stimulation (NPS) in Patients With Seborrheic Keratosis Completed NCT03846531
14 Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses? Completed NCT01159860
15 Effectiveness, Safety, and Cost Efficacy of Water (H2O) as a Substitute for Sodium Bicarbonate (NaHCO3) Plus Solution in Neutralization of Chemical Peeling Using 35% Glycolic Acid Solution Recruiting NCT04154436
16 Skin Lesion Detection With Novel Total Body Digital Photography Smartphone Application Active, not recruiting NCT02740257
17 Laser Treatment of Genito-urinary Syndrome in Women With Breast and Endometrial Cancer and Menopausal Women Not yet recruiting NCT03238053

Search NIH Clinical Center for Inverted Follicular Keratosis

Genetic Tests for Inverted Follicular Keratosis

Anatomical Context for Inverted Follicular Keratosis

MalaCards organs/tissues related to Inverted Follicular Keratosis:

40
Skin, Breast, Eye, Testes, T Cells, Heart, Smooth Muscle

Publications for Inverted Follicular Keratosis

Articles related to Inverted Follicular Keratosis:

(show top 50) (show all 864)
# Title Authors PMID Year
1
The dermoscopic features of facial aging among Egyptians: A comparative study between males and females. 61
30884122 2019
2
Epidermal streaming seen in a seborrheic keratosis using reflectance confocal microscopy and histopathology correlation. 61
31799353 2019
3
p53-regulated long non-coding RNA PRECSIT promotes progression of cutaneous squamous cell carcinoma via STAT3 signaling. 61
31837949 2019
4
Spectral indexes obtained by implementation of the fractional Fourier and Hermite transform for the diagnosis of malignant melanoma. 61
31853384 2019
5
Basaloid tumors arising from seborrheic keratosis: Malignant basal cell carcinoma or benign basaloid follicular hamartomatous proliferation? 61
31682281 2019
6
Evaluation of dermoscopic criteria for seborrheic keratosis on non-polarized versus polarized dermoscopy. 61
31115096 2019
7
[A clinicopathological classification analysis of ocular mass lesions in 7 910 cases]. 61
31715682 2019
8
Hydrogen Peroxide 40% (Eskata) for Seborrheic Keratosis. 61
31730314 2019
9
Seborrheic Keratosis in the Auricle: A Rare Tumor. 61
31722568 2019
10
[Clinical-pathological analysis of 71 cases of dermatosis papulosa nigra of Han Chinese people]. 61
31607018 2019
11
Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern. 61
31157457 2019
12
Dermoscopic-Histopathological Correlation of Eccrine Poroma: An Observational Study. 61
31723462 2019
13
Melanoacanthoma: a potential pitfall of reflectance confocal microscopy. 61
31789261 2019
14
The Prognostic Value of Podoplanin Expression in Nonmelanoma Skin Cancers: Correlation With Lymphatic Vessel Density. 61
31688008 2019
15
Proportion of Potentially Avoidable Referrals From Primary Care to Dermatologists for Cystic Lesions or Benign Neoplasms in Spain: Analysis of Data From the DIADERM Study. 61
31153547 2019
16
Gabor wavelet-based deep learning for skin lesion classification. 61
31499395 2019
17
Efficacy and Tolerability of Topical Polyphenon E in Multiple "Seborrheic Keratosis-Like" Lesions of the Groin in an Immunocompetent 26-Year-Old Man. 61
31824278 2019
18
Miscellaneous Perianal Afflictions. 61
31507350 2019
19
X-band EPR Spectroscopic Investigation of Seborrheic Keratosis. 61
31155544 2019
20
Seborrheic Keratosis or Squamous Carcinoma? Clinical Examination versus Biopsy: The Importance of Criticism. 61
31120423 2019
21
Onychomatricoma Micropapilliferum, a New Variant of Onychomatricoma: Clinical, Dermoscopical, and Histological Correlations (Report of 4 Cases). 61
31436573 2019
22
Atrophic and hypertrophic photoaging: Clinical, histologic, and molecular features of 2 distinct phenotypes of photoaged skin. 61
30954583 2019
23
Dermatopathological characteristics of dermatofibromas from dermatoscopic clues. 61
31264200 2019
24
Dermatoses in parkinsonism: the importance of multidisciplinary follow-up. 61
31340306 2019
25
Value of Dermoscopy in a Population-Based Screening Sample by Dermatologists. 61
31384493 2019
26
Clinical Experience With 40% Hydrogen Peroxide Topical Solution for the Treatment of Seborrheic Keratosis 61
31336413 2019
27
A Rare Pigmented Lesion of the Eyelid. 61
31523108 2019
28
Comparison of the accuracy of human readers versus machine-learning algorithms for pigmented skin lesion classification: an open, web-based, international, diagnostic study. 61
31201137 2019
29
The Application of Deep Learning in the Risk Grading of Skin Tumors for Patients Using Clinical Images. 61
31300897 2019
30
Dermatologic Problems Commonly Seen by the Allergist/Immunologist. 61
31351991 2019
31
Enhancing Outcomes in Seborrheic Keratosis: Using a Novel Treatment Solution 61
31336414 2019
32
The Many Faces of Seborrheic Keratosis. 61
30846163 2019
33
Clonal highlights: Clonal seborrheic keratoses often demonstrates p16 expression. 61
30828837 2019
34
Reflectance confocal microscopy terminology glossary for nonmelanocytic skin lesions: A systematic review. 61
30529706 2019
35
Reflectance confocal microscopy in the diagnosis of pigmented macules of the face: differential diagnosis and margin definition. 61
30938378 2019
36
Ki-67 and p16 Immunostaining Differentiates Pagetoid Bowen Disease From "Microclonal" Seborrheic Keratosis. 61
30852607 2019
37
Pigmented Basal Cell Carcinoma Masquerading as a Melanoma. 61
31192074 2019
38
A novel Nitrizinc Complex® solution for topical treatment of seborrhoeic keratosis: an interventional clinical study. 61
31106762 2019
39
[Trained eye vs. gold standard]. 61
30415882 2019
40
Periocular inverted follicular keratosis: a retrospective series over 17 years. 61
30604112 2019
41
A diagnostic challenge: inflamed and pigmented seborrheic keratosis. Clinical, dermoscopic, and histopathological correlation. 61
30982311 2019
42
Acanthosis nigricans, hypochondroplasia, and FGFR3 mutations: Findings with five new patients, and a review of the literature. 61
30762251 2019
43
Seborrheic keratosis-like lesions localized to tattoo. 61
30891479 2019
44
Verrucous melanoma masquerading as a seborrheic keratosis. 61
30865414 2019
45
Eskata® (Hydrogen Peroxide 40%)-A Treatment for Seborrheic Keratosis. 61
31627790 2019
46
Clonal seborrheic keratosis: a rare skin tumor. 61
31762920 2019
47
Recent advances in managing and understanding seborrheic keratosis. 61
31508199 2019
48
Clinical spectrum of cutaneous melanoma morphology. 61
30165162 2019
49
Teaching Benign Skin Lesions as a Strategy to Improve the Triage Amalgamated Dermoscopic Algorithm (TADA). 61
30610147 2019
50
Verruca plana mimicking seborrheic keratosis in the elderly: A case report. 61
31754601 2019

Variations for Inverted Follicular Keratosis

Expression for Inverted Follicular Keratosis

Search GEO for disease gene expression data for Inverted Follicular Keratosis.

Pathways for Inverted Follicular Keratosis

Pathways related to Inverted Follicular Keratosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.52 GP6 GP5
2
Show member pathways
11.45 GP6 GP5
3 11.25 GP6 GP5
4 10.66 GP6 GP5
5 9.74 GP6 GP5

GO Terms for Inverted Follicular Keratosis

Biological processes related to Inverted Follicular Keratosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 8.96 GP6 GP5
2 hemostasis GO:0007599 8.62 GP6 GP5

Sources for Inverted Follicular Keratosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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