MCID: INV005
MIFTS: 31

Inverted Follicular Keratosis

Categories: Skin diseases

Aliases & Classifications for Inverted Follicular Keratosis

MalaCards integrated aliases for Inverted Follicular Keratosis:

Name: Inverted Follicular Keratosis 12 15 73
Inverted Folicular Keratosis 12
Seborrheic Keratosis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6945
NCIt 50 C9007
UMLS 73 C0334019

Summaries for Inverted Follicular Keratosis

MalaCards based summary : Inverted Follicular Keratosis, also known as inverted folicular keratosis, is related to vulvar inverted follicular keratosis and keratosis. An important gene associated with Inverted Follicular Keratosis is SALL1 (Spalt Like Transcription Factor 1), and among its related pathways/superpathways are Platelet activation and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The drugs Pharmaceutical Solutions and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotype is normal.

Wikipedia : 76 Inverted follicular keratosis is a skin condition characterized by asymptomatic, firm, white–tan to pink... more...

Related Diseases for Inverted Follicular Keratosis

Graphical network of the top 20 diseases related to Inverted Follicular Keratosis:



Diseases related to Inverted Follicular Keratosis

Symptoms & Phenotypes for Inverted Follicular Keratosis

MGI Mouse Phenotypes related to Inverted Follicular Keratosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.02 CALB2 GP5 HMBS MTOR SALL1

Drugs & Therapeutics for Inverted Follicular Keratosis

Drugs for Inverted Follicular Keratosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
2
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
3
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
4
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
5
Hydrogen peroxide Approved, Vet_approved Phase 2 7722-84-1 784
6 Anti-Bacterial Agents Phase 1, Phase 2
7 Antibiotics, Antitubercular Phase 1, Phase 2
8 Immunosuppressive Agents Phase 1, Phase 2
9 Anti-Infective Agents Phase 1, Phase 2
10 Antifungal Agents Phase 1, Phase 2
11
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
12
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
13
Racepinephrine Approved Not Applicable 329-65-7 838
14 Anesthetics Not Applicable
15 Epinephryl borate Not Applicable

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 An A Study Assessing Subject Satisfaction With A-101 Topical Solution for Seborrheic Keratoses Recruiting NCT03487588 Phase 4 A-101 Topical Solution
2 A Study of A-101 Solution 40% in Subjects With Seborrheic Keratosis. Completed NCT02667236 Phase 3 A-101 Solution
3 A Randomized, Double-Blind, Vehicle-Controlled Study in Subjects With Seborrheic Keratosis Completed NCT02667275 Phase 3 A-101 Solution
4 An Open-Label Safety Study of A-101 Solution Completed NCT02667288 Phase 3 A-101 Solution
5 Dose-Response Profile of A-101 in Subjects With Seborrheic Keratosis Unknown status NCT02160626 Phase 2 A-101 Vehicle;A-101 (40) Topical Solution;A-101 (32.5) Topical Solution
6 Study to Evaluate the Safety and Efficacy of PEP005(Ingenol Mebutate) Gel, 0.05%, in Patients With Seborrhoeic Keratosis Completed NCT01214564 Phase 2 PEP005 (ingenol mebutate) Gel
7 Study of A-101 for the Treatment of Seborrheic Keratosis Completed NCT02260180 Phase 2 A-101
8 Study of Safety, Tolerability and Effectiveness of A-101 in Subjects With Seborrheic Keratosis Completed NCT01986920 Phase 1, Phase 2 A-101 25%;A-101 32.5%;A-101 40%;A-101 Vehicle
9 A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis Recruiting NCT03148691 Phase 2 A-101
10 Novel Compositions for Treating or Preventing Dermal Disorders Recruiting NCT03103893 Phase 1, Phase 2 Rapamycin
11 In-vivo Optical Coherence Tomography Imaging in Dermatooncology Unknown status NCT01680562
12 Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses? Completed NCT01159860 Not Applicable
13 Dermatosis Papulosa Nigra Completed NCT00710203 Not Applicable
14 Analysis of Melanocytes (Pigment Cells) in Sun-Exposed Skin Completed NCT00875381
15 Optical Biopsy of Human Skin in Conjunction With Laser Treatment Completed NCT00540566
16 Electrocautery vs Q-switch for Seborrheic Keratosis Withdrawn NCT02366559 Not Applicable

Search NIH Clinical Center for Inverted Follicular Keratosis

Genetic Tests for Inverted Follicular Keratosis

Anatomical Context for Inverted Follicular Keratosis

MalaCards organs/tissues related to Inverted Follicular Keratosis:

41
Skin

Publications for Inverted Follicular Keratosis

Articles related to Inverted Follicular Keratosis:

(show all 34)
# Title Authors Year
1
Reflectance confocal microscopy of an inverted follicular keratosis mimicking a squamous cell carcinoma. ( 29214108 )
2017
2
Inverted follicular keratosis successfully treated with imiquimod. ( 27294052 )
2016
3
Dermoscopy of inverted follicular keratosis: study of 12 cases. ( 27018237 )
2016
4
Rare case of external dental fistula of the submental region misdiagnosed as inverted follicular keratosis and thyroglossal duct cyst. ( 26413920 )
2015
5
Inverted follicular keratosis of the lip. ( 25469197 )
2014
6
Inverted follicular keratosis: dermoscopic and reflectance confocal microscopic features. ( 23988627 )
2013
7
Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis. ( 19615018 )
2010
8
Inverted follicular keratosis of the nasal vestibule. ( 19643268 )
2009
9
Inverted follicular keratosis with sebaceoma-like areas: first case report. ( 19638553 )
2009
10
[Acral keratoses and inverted follicular keratosis presenting Cowden disease]. ( 17663933 )
2007
11
Conjunctival inverted follicular keratosis: a case report. ( 15486776 )
2004
12
Inverted follicular keratosis simulating malignant melanoma. ( 14961911 )
2004
13
Inverted follicular keratosis. ( 11411260 )
2001
14
Inverted follicular keratosis of the vulvar skin: a lesion that can be confused with squamous cell carcinoma. ( 11109167 )
2000
15
Inverted follicular keratosis. ( 8214316 )
1993
16
Inverted follicular keratosis and papillomavirus infection. ( 1851400 )
1991
17
Inverted follicular keratosis. A report of two recurrent cases. ( 3684220 )
1987
18
Inverted follicular keratosis. ( 2409255 )
1985
19
Inverted follicular keratosis of the lip. ( 6588345 )
1984
20
Inverted follicular keratosis and verruca vulgaris. An investigation for the papillomavirus common antigen. ( 6330188 )
1984
21
Inverted follicular keratosis and human papillomaviruses. ( 6318588 )
1983
22
The nosologic position of inverted follicular keratosis is still unsettled. ( 6229189 )
1983
23
Inverted follicular keratosis. A morbus sui generis? ( 6660429 )
1983
24
Inverted follicular keratosis is a distinct follicular tumor. ( 6660428 )
1983
25
Inverted follicular keratosis is an irritated seborrheic keratosis. ( 6229190 )
1983
26
Inverted follicular keratosis is not a specific keratosis but a verruca vulgaris (or seborrheic keratosis) with squamous eddies. ( 6229188 )
1983
27
Pilar acanthoma: a combination of inverted follicular keratosis and sebaceous trichofolliculoma. ( 7037900 )
1981
28
Inverted follicular keratosis. ( 453311 )
1979
29
Inverted follicular keratosis in a dog. ( 442466 )
1979
30
Inverted follicular keratosis clinically mimicking malignant melanoma. ( 900725 )
1977
31
The inverted follicular keratosis. A surprising variant of seborrheic wart. ( 78617 )
1976
32
Inverted follicular keratosis. ( 1141446 )
1975
33
INVERTED FOLLICULAR KERATOSIS. ( 14081564 )
1964
34
Eyelid tumors with reference to lesions confused with squamous cell carcinoma. II. Inverted follicular keratosis. ( 13968810 )
1963

Variations for Inverted Follicular Keratosis

Expression for Inverted Follicular Keratosis

Search GEO for disease gene expression data for Inverted Follicular Keratosis.

Pathways for Inverted Follicular Keratosis

Pathways related to Inverted Follicular Keratosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.25 GP5 GP6
2 10.66 GP5 GP6
3 9.74 GP5 GP6

GO Terms for Inverted Follicular Keratosis

Biological processes related to Inverted Follicular Keratosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 9.16 GP5 GP6
2 positive regulation of translation GO:0045727 8.96 KRT17 MTOR
3 hemostasis GO:0007599 8.62 GP5 GP6

Sources for Inverted Follicular Keratosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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