MCID: INV005
MIFTS: 26

Inverted Follicular Keratosis

Categories: Cancer diseases, Skin diseases
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Aliases & Classifications for Inverted Follicular Keratosis

MalaCards integrated aliases for Inverted Follicular Keratosis:

Name: Inverted Follicular Keratosis 11 14 16 71
Inverted Folicular Keratosis 11
Seborrheic Keratosis 71

Classifications:



External Ids:

Disease Ontology 11 DOID:6945
NCIt 49 C9007
SNOMED-CT 68 201096007
UMLS 71 C0022603 C0334019

Summaries for Inverted Follicular Keratosis

MalaCards based summary: Inverted Follicular Keratosis, also known as inverted folicular keratosis, is related to vulvar inverted follicular keratosis and keratosis. An important gene associated with Inverted Follicular Keratosis is PHLDA1 (Pleckstrin Homology Like Domain Family A Member 1), and among its related pathways/superpathways are "Platelet Aggregation Inhibitor Pathway, Pharmacodynamics" and Platelet Adhesion to exposed collagen. The drugs Hydrogen peroxide and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin.

Related Diseases for Inverted Follicular Keratosis

Diseases related to Inverted Follicular Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 vulvar inverted follicular keratosis 11.7
2 keratosis 10.9
3 keratosis, seborrheic 10.3
4 common wart 10.3
5 basal cell carcinoma 1 10.2
6 melanoma 10.2
7 basal cell carcinoma 10.2
8 papilloma 10.2
9 muir-torre syndrome 10.1
10 cowden syndrome 1 10.1
11 polycystic liver disease 1 with or without kidney cysts 10.1
12 thyroglossal duct cyst, familial 10.1
13 chronic apical periodontitis 10.1
14 acanthoma 10.1
15 squamous cell carcinoma 10.1
16 thyroid gland cancer 10.1
17 keratoacanthoma 10.1
18 skin benign neoplasm 10.1
19 skin carcinoma 10.1
20 amelanotic melanoma 10.1
21 eccrine acrospiroma 10.1
22 cowden syndrome 10.1
23 periapical periodontitis 10.1
24 periodontitis 10.1
25 in situ carcinoma 10.1
26 pyogenic granuloma 10.1
27 trichofolliculoma 10.1
28 follicular infundibulum tumor 10.0 PHLDA1 KRT17
29 morpheaform basal cell carcinoma 10.0 PHLDA1 KRT17
30 basosquamous carcinoma 10.0 PTGER4 PHLDA1
31 squamous papillomatosis 10.0 PTGER4 PHLDA1
32 eccrine sweat gland cancer 10.0 PTGER4 PHLDA1
33 clear cell basal cell carcinoma 10.0 PHLDA1 KRT17
34 hair follicle neoplasm 9.9 PHLDA1 KRT17
35 basaloid squamous cell carcinoma 9.9 PTGER4 KRT17
36 large cell acanthoma 9.9 PTGER4 KRT17
37 comedo carcinoma 9.9 PTGER4 GP5
38 borst-jadassohn intraepidermal carcinoma 9.9 PTGER4 KRT17
39 pilomatrixoma 9.9 PHLDA1 KRT17
40 middle ear squamous cell carcinoma 9.8 GP6 GP5
41 focal epithelial hyperplasia 9.8 GP6 GP5
42 malignant syringoma 9.7 PTGER4 PHLDA1 KRT17
43 cervical adenosarcoma 9.7 GP6 GP5
44 chronic cervicitis 9.7 GP6 GP5
45 cervicitis 9.7 GP6 GP5
46 anus cancer 9.7 GP6 GP5
47 anogenital venereal wart 9.7 GP6 GP5
48 thrombocytopenia due to platelet alloimmunization 9.7 GP6 GP5
49 gray platelet syndrome 9.7 GP6 GP5
50 penile cancer 9.6 GP6 GP5

Graphical network of the top 20 diseases related to Inverted Follicular Keratosis:



Diseases related to Inverted Follicular Keratosis

Symptoms & Phenotypes for Inverted Follicular Keratosis

Drugs & Therapeutics for Inverted Follicular Keratosis

Drugs for Inverted Follicular Keratosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
2 Pharmaceutical Solutions Phase 4
3
Petrolatum Approved, Investigational 8009-03-8
4
Fusidic acid Approved, Investigational 6990-06-3 3000226
5
Chlorhexidine Approved, Vet_approved 55-56-1 2713 9552079
6 Anti-Infective Agents
7 Anti-Bacterial Agents
8 Emollients
9 Dermatologic Agents
10 Chlorhexidine gluconate

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 An Open-Label Study Assessing Subject Satisfaction With A-101 Hydrogen Peroxide Topical Solution, 40% (w/w) Treatment for Seborrheic Keratoses of the Face, Neck, and Decolletage Completed NCT03487588 Phase 4 A-101 Topical Solution
2 An Open-Label Study of the Safety of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face. Completed NCT02667288 Phase 3 A-101 Solution
3 A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Safety and Effectiveness of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face. Completed NCT02667236 Phase 3 A-101 Solution
4 A Randomized, Double-Blind, Vehicle-Controlled, PArallel Group Study of the Safety and Effectiveness of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face. Completed NCT02667275 Phase 3 A-101 Solution
5 A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Dose-Response Profile of A-101 Topical Solution in Subjects With Seborrheic Keratosis of the Face Completed NCT02260180 Phase 2 A-101
6 A Randomized, Double-Blind, Vehicle-Controlled, Within-Subject, Comparison Study of the Safety, Tolerability, And Effectiveness of A-101 Topical Solution in Subjects With Seborrheic Keratosis Completed NCT01986920 Phase 1, Phase 2 A-101 25%;A-101 32.5%;A-101 40%;A-101 Vehicle
7 A Randomized, Double-Blind, Vehicle Controlled, Parallel Group Study of the Dose-Response Profile of A-101 Topical Solution in Subjects With Seborrheic Keratosis. Completed NCT02160626 Phase 2 A-101 Vehicle;A-101 (40) Topical Solution;A-101 (32.5) Topical Solution
8 A Phase 2 Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Safety and Effectiveness of A-101(Hydrogen Peroxide) Topical Solution in Subjects With Seborrheic Keratosis Lesions on the Trunk, Extremities, and Face Completed NCT03148691 Phase 2 A-101
9 A Phase 2a, Multi-Centre, Open-Label Study to Evaluate the Safety and Efficacy of PEP005(Ingenol Mebutate) Gel, 0.05%, in Patients With Seborrhoeic Keratosis on Non-head Locations Completed NCT01214564 Phase 2 PEP005 (ingenol mebutate) Gel
10 Open Label Adaptive Design Study to Explore the Safety and Efficacy of Multiple Treatment Regimens With the Akt Inhibitor SM-020 in 1.0% and 0.1% Gel Formulations in Subjects With Seborrheic Keratosis Recruiting NCT05136144 Phase 2 SM-020
11 Fast Track Diagnosis of Skin Tumours by Four Different Advanced Imaging Technologies - a Clinical Study Unknown status NCT04229277
12 Evaluation of Nano-Pulse Stimulation (NPS) in Patients With Seborrheic Keratosis Completed NCT03846531
13 Optical Biopsy of Human Skin in Conjunction With Laser Treatment Completed NCT00540566
14 Effectiveness of Sodium Fusidate Ointment Compared to Petrolatum for Wound Healing Following Cauterization: A Double-Blind Randomized Controlled Trial Completed NCT05353374 Sodium Fusidate 2 % Topical Ointment;Petrolatum ointment
15 Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses? Completed NCT01159860
16 Prospective, Open-Label, Multi-Center, Non-Significant Risk Study of Nano-Pulse Stimulation™ (NPS™) Technology in Healthy Adults With Seborrheic Keratosis Active, not recruiting NCT04249115
17 Comparative Study of Electrical Impedance Spectroscopy (EIS) Models Against Verified Dermatological Diagnostic Data Suspended NCT04688749

Search NIH Clinical Center for Inverted Follicular Keratosis

Genetic Tests for Inverted Follicular Keratosis

Anatomical Context for Inverted Follicular Keratosis

Organs/tissues related to Inverted Follicular Keratosis:

MalaCards : Skin

Publications for Inverted Follicular Keratosis

Articles related to Inverted Follicular Keratosis:

(show top 50) (show all 66)
# Title Authors PMID Year
1
A case of adnexal tumor combining inverted follicular keratosis and trichoblastoma: molecular genetics evidence against a pathogenetic role of human Papillomaviruses. 62
33890741 2022
2
Inverted follicular keratosis: dermoscopic features of 23 cases. 62
32129053 2021
3
Cutaneous Horn Overlying Inverted Follicular Keratosis: A Rare Case Report. 62
34430483 2021
4
A rare case of inverted follicular keratosis in an elderly male: Dermoscopic and histopathological overview with therapeutic response to imiquimod. 62
33943061 2021
5
Periocular inverted follicular keratosis: a retrospective series over 17 years. 62
30604112 2019
6
Inverted Follicular Keratosis: Stand-Alone Entity or Variant. 62
31145057 2019
7
Giant Squamous Cell Papilloma of the Eyelid-Diagnostic and Therapeutic Challenges. 62
31781447 2019
8
Composite trichoblastoma and inverted follicular keratosis: a case report. 62
31938412 2018
9
Reflectance confocal microscopy of an inverted follicular keratosis mimicking a squamous cell carcinoma. 62
29214108 2017
10
Cutaneous Horn of the Eyelid in 13 Cases. 62
27811637 2017
11
Dermoscopy of inverted follicular keratosis: study of 12 cases. 62
27018237 2016
12
Inverted follicular keratosis successfully treated with imiquimod. 62
27294052 2016
13
Pseudoepitheliomatous changes in a case of vegetating Darier–White disease: a unique histopathological finding. 62
25238450 2015
14
Rare case of external dental fistula of the submental region misdiagnosed as inverted follicular keratosis and thyroglossal duct cyst. 62
26413920 2015
15
Human Papillomavirus Deoxyribonucleic Acid may not be Detected in Non-genital Benign Papillomatous Skin Lesions by Polymerase Chain Reaction. 62
25071248 2014
16
Inverted follicular keratosis of the lip. 62
25469197 2014
17
Inverted follicular keratosis: dermoscopic and reflectance confocal microscopic features. 62
23988627 2013
18
Simulators of squamous cell carcinoma of the skin: diagnostic challenges on small biopsies and clinicopathological correlation. 62
23878739 2013
19
Pigmented tumor in the nostril. 62
24396720 2011
20
Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis. 62
19615018 2010
21
Inverted follicular keratosis of the nasal vestibule. 62
19643268 2009
22
Inverted follicular keratosis with sebaceoma-like areas: first case report. 62
19638553 2009
23
Are all seborrheic keratoses benign? Review of the typical lesion and its variants. 62
18845088 2008
24
[Immunohistochemical study of calretinin in normal hair follicles and tumors with follicular differentiation]. 62
18558053 2008
25
[Acral keratoses and inverted follicular keratosis presenting Cowden disease]. 62
17663933 2007
26
[Benign pigmented lesions of the eyelids]. 62
16249773 2005
27
Conjunctival inverted follicular keratosis: a case report. 62
15486776 2004
28
Multiple inverted follicular keratoses as a presenting sign of Cowden's syndrome: case report with human papillomavirus studies. 62
15337985 2004
29
Inverted follicular keratosis simulating malignant melanoma. 62
14961911 2004
30
[Benign hair-follicle derived eyelids tumors in adults]. 62
12410406 2002
31
Inverted follicular keratosis. 62
11411260 2001
32
Inverted follicular keratosis of the vulvar skin: a lesion that can be confused with squamous cell carcinoma. 62
11109167 2000
33
Verrucous cysts: histopathologic characterization and molecular detection of human papillomavirus-specific DNA. 62
8300926 1993
34
Inverted follicular keratosis. 62
8214316 1993
35
Inverted follicular keratosis and papillomavirus infection. 62
1851400 1991
36
[Histologic aspects of seborrheic keratosis]. 62
2145481 1990
37
Multiple infundibular tumours of the head and neck. 62
2757928 1989
38
Inverted follicular keratosis. A report of two recurrent cases. 62
3684220 1987
39
Squamous cell carcinoma of the eyelids. 62
3601369 1987
40
Inverted follicular keratosis. 62
2409255 1985
41
The cutaneous pathology of Cowden's disease: new findings. 62
2582011 1985
42
Inverted follicular keratosis of the lip. 62
6588345 1984
43
Inverted follicular keratosis and verruca vulgaris. An investigation for the papillomavirus common antigen. 62
6330188 1984
44
Inverted follicular keratosis is not a specific keratosis but a verruca vulgaris (or seborrheic keratosis) with squamous eddies. 62
6229188 1983
45
Inverted follicular keratosis and human papillomaviruses. 62
6318588 1983
46
Inverted follicular keratosis is a distinct follicular tumor. 62
6660428 1983
47
Inverted follicular keratosis is an irritated seborrheic keratosis. 62
6229190 1983
48
Inverted follicular keratosis. A morbus sui generis? 62
6660429 1983
49
The nosologic position of inverted follicular keratosis is still unsettled. 62
6229189 1983
50
[Clinico-pathological analysis of inverted follicular keratosis of the eyelid and eyebrows]. 62
6816542 1982

Variations for Inverted Follicular Keratosis

Expression for Inverted Follicular Keratosis

Search GEO for disease gene expression data for Inverted Follicular Keratosis.

Pathways for Inverted Follicular Keratosis

Pathways related to Inverted Follicular Keratosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 GP6 GP5
2
Show member pathways
10.05 GP6 GP5

GO Terms for Inverted Follicular Keratosis

Biological processes related to Inverted Follicular Keratosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.13 GP6 GP5
2 hemostasis GO:0007599 8.62 GP6 GP5

Sources for Inverted Follicular Keratosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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