Inverted Follicular Keratosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Inverted Follicular Keratosis

MalaCards integrated aliases for Inverted Follicular Keratosis:

Name: Inverted Follicular Keratosis ¹¹ ¹⁴ ¹⁶ ⁷¹

Inverted Folicular Keratosis ¹¹

Seborrheic Keratosis ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:6945

NCIt ⁴⁹ C9007

SNOMED-CT ⁶⁸ 201096007

EFO ¹⁶ EFO_1000717

UMLS ⁷¹ C0022603 C0334019

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Summaries for Inverted Follicular Keratosis

MalaCards based summary: Inverted Follicular Keratosis, also known as inverted folicular keratosis, is related to vulvar inverted follicular keratosis and keratosis. An important gene associated with Inverted Follicular Keratosis is PHLDA1 (Pleckstrin Homology Like Domain Family A Member 1), and among its related pathways/superpathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Platelet Adhesion to exposed collagen. The drugs Hydrogen peroxide and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin.

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Related Diseases for Inverted Follicular Keratosis

Diseases related to Inverted Follicular Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 54, show less)

#	Related Disease	Score	Top Affiliating Genes
1	vulvar inverted follicular keratosis	11.7
2	keratosis	10.9
3	basal cell carcinoma	10.4
4	keratosis, seborrheic	10.3
5	basal cell carcinoma 1	10.3
6	common wart	10.3
7	melanoma	10.2
8	papilloma	10.2
9	muir-torre syndrome	10.1
10	cowden syndrome 1	10.1
11	thyroglossal duct cyst, familial	10.1
12	chronic apical periodontitis	10.1
13	acanthoma	10.1
14	squamous cell carcinoma	10.1
15	thyroid gland cancer	10.1
16	keratoacanthoma	10.1
17	skin benign neoplasm	10.1
18	skin carcinoma	10.1
19	amelanotic melanoma	10.1
20	eccrine acrospiroma	10.1
21	cowden syndrome	10.1
22	periapical periodontitis	10.1
23	periodontitis	10.1
24	pyogenic granuloma	10.1
25	trichofolliculoma	10.1
26	follicular infundibulum tumor	10.1	PHLDA1 KRT17
27	morpheaform basal cell carcinoma	10.1	PHLDA1 KRT17
28	basosquamous carcinoma	10.0	PTGER4 PHLDA1
29	squamous papillomatosis	10.0	PTGER4 PHLDA1
30	clear cell basal cell carcinoma	10.0	PHLDA1 KRT17
31	hair follicle neoplasm	10.0	PHLDA1 KRT17
32	large cell acanthoma	10.0	PTGER4 KRT17
33	comedo carcinoma	10.0	PTGER4 GP5
34	borst-jadassohn intraepidermal carcinoma	9.9	PTGER4 KRT17
35	middle ear squamous cell carcinoma	9.9	GP6 GP5
36	pilomatrixoma	9.9	PHLDA1 KRT17
37	focal epithelial hyperplasia	9.9	GP6 GP5
38	cervical adenosarcoma	9.9	GP6 GP5
39	chronic cervicitis	9.9	GP6 GP5
40	cervicitis	9.9	GP6 GP5
41	anus cancer	9.8	GP6 GP5
42	anogenital venereal wart	9.8	GP6 GP5
43	hidradenoma	9.8	PHLDA1 NUTM1
44	gray platelet syndrome	9.8	GP6 GP5
45	malignant syringoma	9.8	PTGER4 PHLDA1 KRT17
46	penile cancer	9.8	GP6 GP5
47	epidermodysplasia verruciformis 1	9.7	GP6 GP5
48	uterus carcinoma in situ	9.7	KRT17 GP6 GP5
49	cervix uteri carcinoma in situ	9.7	KRT17 GP6 GP5
50	bernard-soulier syndrome	9.7	GP6 GP5
51	penis basal cell carcinoma	9.7	PTGER4 GP6 GP5
52	eccrine sweat gland cancer	9.6	PTGER4 PHLDA1 NUTM1
53	basaloid squamous cell carcinoma	9.6	PTGER4 NUTM1 KRT17
54	blood platelet disease	9.6	GP6 GP5

Graphical network of the top 20 diseases related to Inverted Follicular Keratosis:

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Symptoms & Phenotypes for Inverted Follicular Keratosis

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Drugs & Therapeutics for Inverted Follicular Keratosis

Drugs for Inverted Follicular Keratosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 10, show less)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Hydrogen peroxide

Approved, Vet_approved

Phase 4

7722-84-1

784

2

Pharmaceutical Solutions

Phase 4

3

Fusidic acid

Approved, Investigational

6990-06-3

3000226

4

Petrolatum

Approved, Investigational

8009-03-8

5

Chlorhexidine

Approved, Vet_approved, Withdrawn

55-56-1

2713 9552079

6

Anti-Bacterial Agents

7

Anti-Infective Agents

8

Emollients

9

Dermatologic Agents

10

Chlorhexidine gluconate

Interventional clinical trials:

(showing 17, show less)

#	Name	Status	NCT ID	Phase	Drugs
1	An Open-Label Study Assessing Subject Satisfaction With A-101 Hydrogen Peroxide Topical Solution, 40% (w/w) Treatment for Seborrheic Keratoses of the Face, Neck, and Decolletage	Completed	NCT03487588	Phase 4	A-101 Topical Solution
2	An Open-Label Study of the Safety of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face.	Completed	NCT02667288	Phase 3	A-101 Solution
3	A Randomized, Double-Blind, Vehicle-Controlled, PArallel Group Study of the Safety and Effectiveness of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face.	Completed	NCT02667275	Phase 3	A-101 Solution
4	A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Safety and Effectiveness of A-101 Solution 40% in Subjects With Seborrheic Keratosis on the Trunk, Extremities and Face.	Completed	NCT02667236	Phase 3	A-101 Solution
5	A Randomized, Double-Blind, Vehicle-Controlled, Within-Subject, Comparison Study of the Safety, Tolerability, And Effectiveness of A-101 Topical Solution in Subjects With Seborrheic Keratosis	Completed	NCT01986920	Phase 1, Phase 2	A-101 25%;A-101 32.5%;A-101 40%;A-101 Vehicle
6	A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Dose-Response Profile of A-101 Topical Solution in Subjects With Seborrheic Keratosis of the Face	Completed	NCT02260180	Phase 2	A-101
7	A Phase 2 Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Safety and Effectiveness of A-101(Hydrogen Peroxide) Topical Solution in Subjects With Seborrheic Keratosis Lesions on the Trunk, Extremities, and Face	Completed	NCT03148691	Phase 2	A-101
8	A Randomized, Double-Blind, Vehicle Controlled, Parallel Group Study of the Dose-Response Profile of A-101 Topical Solution in Subjects With Seborrheic Keratosis.	Completed	NCT02160626	Phase 2	A-101 Vehicle;A-101 (40) Topical Solution;A-101 (32.5) Topical Solution
9	A Phase 2a, Multi-Centre, Open-Label Study to Evaluate the Safety and Efficacy of PEP005(Ingenol Mebutate) Gel, 0.05%, in Patients With Seborrhoeic Keratosis on Non-head Locations	Completed	NCT01214564	Phase 2	PEP005 (ingenol mebutate) Gel
10	Open Label Adaptive Design Study to Explore the Safety and Efficacy of Multiple Treatment Regimens With the Akt Inhibitor SM-020 in 1.0% and 0.1% Gel Formulations in Subjects With Seborrheic Keratosis	Recruiting	NCT05136144	Phase 2	SM-020
11	Fast Track Diagnosis of Skin Tumours by Four Different Advanced Imaging Technologies - a Clinical Study	Unknown status	NCT04229277
12	Prospective, Open-Label, Multi-Center, Non-Significant Risk Study of Nano-Pulse Stimulation™ (NPS™) Technology in Healthy Adults With Seborrheic Keratosis	Completed	NCT04249115
13	Evaluation of Nano-Pulse Stimulation (NPS) in Patients With Seborrheic Keratosis	Completed	NCT03846531
14	Optical Biopsy of Human Skin in Conjunction With Laser Treatment	Completed	NCT00540566
15	Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses?	Completed	NCT01159860
16	Effectiveness of Sodium Fusidate Ointment Compared to Petrolatum for Wound Healing Following Cauterization: A Double-Blind Randomized Controlled Trial	Completed	NCT05353374		Sodium Fusidate 2 % Topical Ointment;Petrolatum ointment
17	Comparative Study of Electrical Impedance Spectroscopy (EIS) Models Against Verified Dermatological Diagnostic Data	Suspended	NCT04688749

Search NIH Clinical Center for Inverted Follicular Keratosis

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Genetic Tests for Inverted Follicular Keratosis

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Anatomical Context for Inverted Follicular Keratosis

Organs/tissues related to Inverted Follicular Keratosis:

MalaCards : Skin

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Publications for Inverted Follicular Keratosis

Articles related to Inverted Follicular Keratosis:

(showing 69, show less)

#	Title	Authors	PMID	Year
1	Seborrheic Keratosis With Malignant Transformation (Invasive or Noninvasive Squamous Cell Carcinoma Arising in Seborrheic Keratosis): A Clinicopathologic and Immunohistochemical Study of 11 Cases. ⁶²	Goto K...Honma K	36395445	2022
2	Two Distinct Lesions of Inverted Follicular Keratosis of the Scalp: A Case Report. ⁶²	Heriyanto DS...Phang V	36349066	2022
3	Pigmented inverted follicular keratosis masquerading as basal cell carcinoma. ⁶²	Kumar P...Neema S	36304658	2022
4	A case of adnexal tumor combining inverted follicular keratosis and trichoblastoma: molecular genetics evidence against a pathogenetic role of human Papillomaviruses. ⁶²	Serban D...Corti B	33890741	2022
5	Inverted follicular keratosis: dermoscopic features of 23 cases. ⁶²	Savoia F...DI Altobrando A	32129053	2021
6	Cutaneous Horn Overlying Inverted Follicular Keratosis: A Rare Case Report. ⁶²	Nahata VL	34430483	2021
7	A rare case of inverted follicular keratosis in an elderly male: Dermoscopic and histopathological overview with therapeutic response to imiquimod. ⁶²	Ray A...Mohanty P	33943061	2021
8	Periocular inverted follicular keratosis: a retrospective series over 17 years. ⁶²	Diez-Montero C...Galindo-Ferreiro A	30604112	2019
9	Giant Squamous Cell Papilloma of the Eyelid-Diagnostic and Therapeutic Challenges. ⁶²	Vass A...Toth-Molnar E	31781447	2019
10	Inverted Follicular Keratosis: Stand-Alone Entity or Variant. ⁶²	Shah R...Lambert WC	31145057	2019
11	Composite trichoblastoma and inverted follicular keratosis: a case report. ⁶²	Cho J...Cho HD	31938412	2018
12	Reflectance confocal microscopy of an inverted follicular keratosis mimicking a squamous cell carcinoma. ⁶²	Hocker S...Scope A	29214108	2017
13	Cutaneous Horn of the Eyelid in 13 Cases. ⁶²	Pointdujour-Lim R...Shields CL	27811637	2017
14	Dermoscopy of inverted follicular keratosis: study of 12 cases. ⁶²	Llambrich A...Puig S	27018237	2016
15	Inverted follicular keratosis successfully treated with imiquimod. ⁶²	Karadag AS...Oman B	27294052	2016
16	Pseudoepitheliomatous changes in a case of vegetating Darier–White disease: a unique histopathological finding. ⁶²	Pezzini C...Borroni G	25238450	2015
17	Rare case of external dental fistula of the submental region misdiagnosed as inverted follicular keratosis and thyroglossal duct cyst. ⁶²	Sato T...Takato T	26413920	2015
18	Human Papillomavirus Deoxyribonucleic Acid may not be Detected in Non-genital Benign Papillomatous Skin Lesions by Polymerase Chain Reaction. ⁶²	Kambiz KH...Alireza G	25071248	2014
19	Inverted follicular keratosis of the lip. ⁶²	Mohamed M	25469197	2014
20	Simulators of squamous cell carcinoma of the skin: diagnostic challenges on small biopsies and clinicopathological correlation. ⁶²	Tan KB...Lee YS	23878739	2013
21	Inverted follicular keratosis: dermoscopic and reflectance confocal microscopic features. ⁶²	Armengot-Carbo M...Puig S	23988627	2013
22	Pigmented tumor in the nostril. ⁶²	Jaada N...Ben Osman A	24396720	2011
23	Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis. ⁶²	Battistella M...Cribier B	19615018	2010
24	Inverted follicular keratosis with sebaceoma-like areas: first case report. ⁶²	D'Agostino M...Ghazarian D	19638553	2009
25	Inverted follicular keratosis of the nasal vestibule. ⁶²	Villaret AB...Aga A	19643268	2009
26	Are all seborrheic keratoses benign? Review of the typical lesion and its variants. ⁶²	Noiles K...Vender R	18845088	2008
27	[Immunohistochemical study of calretinin in normal hair follicles and tumors with follicular differentiation]. ⁶²	Gonzalez-Guerra E...Kutzner H	18558053	2008
28	[Acral keratoses and inverted follicular keratosis presenting Cowden disease]. ⁶²	Larumbe A...Gallego M	17663933	2007
29	[Benign pigmented lesions of the eyelids]. ⁶²	Desjardins L	16249773	2005
30	Multiple inverted follicular keratoses as a presenting sign of Cowden's syndrome: case report with human papillomavirus studies. ⁶²	Ruhoy SM...Nuovo GJ	15337985	2004
31	Conjunctival inverted follicular keratosis: a case report. ⁶²	Cakmak SS...Sakalar YB	15486776	2004
32	Inverted follicular keratosis simulating malignant melanoma. ⁶²	Thom GA...Heenan PJ	14961911	2004
33	[Benign hair-follicle derived eyelids tumors in adults]. ⁶²	Mencia Gutierrez E...Garcia Torre JP	12410406	2002
34	Inverted follicular keratosis. ⁶²	Shih CC...Cheng ST	11411260	2001
35	Inverted follicular keratosis of the vulvar skin: a lesion that can be confused with squamous cell carcinoma. ⁶²	Roth LM...Look KY	11109167	2000
36	Verrucous cysts: histopathologic characterization and molecular detection of human papillomavirus-specific DNA. ⁶²	Soyer HP...Kerl H	8300926	1993
37	Inverted follicular keratosis. ⁶²	Soylu L...Tuncer I	8214316	1993
38	Inverted follicular keratosis and papillomavirus infection. ⁶²	Hori K	1851400	1991
39	[Histologic aspects of seborrheic keratosis]. ⁶²	Perez-Oliva N...Quinones PA	2145481	1990
40	Multiple infundibular tumours of the head and neck. ⁶²	Findlay GH	2757928	1989
41	Inverted follicular keratosis. A report of two recurrent cases. ⁶²	Schweitzer JG...Yanoff M	3684220	1987
42	Squamous cell carcinoma of the eyelids. ⁶²	Doxanas MT...Green WR	3601369	1987
43	Inverted follicular keratosis. ⁶²	White DK...Damm DD	2409255	1985
44	The cutaneous pathology of Cowden's disease: new findings. ⁶²	Starink TM...Brownstein MH	2582011	1985
45	Inverted follicular keratosis of the lip. ⁶²	Adrian JC	6588345	1984
46	Inverted follicular keratosis and verruca vulgaris. An investigation for the papillomavirus common antigen. ⁶²	Mehregan AH...Nadji M	6330188	1984
47	Inverted follicular keratosis and human papillomaviruses. ⁶²	Reed RJ...Pulitzer DR	6318588	1983
48	Inverted follicular keratosis is an irritated seborrheic keratosis. ⁶²	Lever WF	6229190	1983
49	Inverted follicular keratosis is not a specific keratosis but a verruca vulgaris (or seborrheic keratosis) with squamous eddies. ⁶²	Spielvogel RL...Ackerman AB	6229188	1983
50	Inverted follicular keratosis is a distinct follicular tumor. ⁶²	Mehregan AH	6660428	1983
51	The nosologic position of inverted follicular keratosis is still unsettled. ⁶²	Lund HZ	6229189	1983
52	Inverted follicular keratosis. A morbus sui generis? ⁶²	Moehlenbeck FW	6660429	1983
53	[Clinico-pathological analysis of inverted follicular keratosis of the eyelid and eyebrows]. ⁶²	Wang Q	6816542	1982
54	[Cutaneous horn. Inverted follicular keratosis with an underlying tricholemmoma]. ⁶²	Garcia e Silva L	6750271	1982
55	Pilar acanthoma: a combination of inverted follicular keratosis and sebaceous trichofolliculoma. ⁶²	Mohri S	7037900	1981
56	[Inverted follicular keratosis]. ⁶²	Aguilar R...Peteiro MC	7331910	1981
57	[The infundibular adenoma: a follicular poroma with sebaceous and apocrine differentiation (author's transl)]. ⁶²	Grosshans E...Hanau D	7235505	1981
58	The intra-epidermal epithelioma of Jadassohn: a distinct entity. ⁶²	Cook MG...Ridgway HA	534611	1979
59	Trichilemmal tumor undergoing specific keratinization: "keratinizing trichilemmoma". ⁶²	Hanau D...Grosshans E	521537	1979
60	Inverted follicular keratosis. ⁶²	Sassani JW...Yanoff M	453311	1979
61	Inverted follicular keratosis in a dog. ⁶²	Goldschmidt MH...Kunkle G	442466	1979
62	Cytologic features of hyperplastic epidermis. ⁶²	Eng AM...Worobec S	604366	1977
63	Inverted follicular keratosis clinically mimicking malignant melanoma. ⁶²	Scheie HG...Sassani JW	900725	1977
64	The inverted follicular keratosis. A surprising variant of seborrheic wart. ⁶²	Sim-Davis D...Wilson-Jones E	78617	1976
65	Inverted follicular keratosis. ⁶²	Azzopardi JG...Laurini R	1141446	1975
66	[Inverted follicular keratosis]. ⁶²	Mohlenbeck FW	1116942	1975
67	[Inverted follicular keratosis]. ⁶²	Zina G...Pippione M	5819120	1969
68	INVERTED FOLLICULAR KERATOSIS. ⁶²	MEHREGAN AH	14081564	1964
69	Eyelid tumors with reference to lesions confused with squamous cell carcinoma. II. Inverted follicular keratosis. ⁶²	BONIUK M...ZIMMERMAN LE	13968810	1963

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Genes for Inverted Follicular Keratosis

Genes related to Inverted Follicular Keratosis (0 elite genes):

(showing 6, show less)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PHLDA1	Pleckstrin Homology Like Domain Family A Member 1	Protein Coding	5.39	DISEASES inferred ¹⁴
2	KRT17	Keratin 17	Protein Coding	5.32	DISEASES inferred ¹⁴
3	GP5	Glycoprotein V Platelet	Protein Coding	5.19	DISEASES inferred ¹⁴
4	GP6	Glycoprotein VI Platelet	Protein Coding	4.87	DISEASES inferred ¹⁴
5	NUTM1	NUT Midline Carcinoma Family Member 1	Protein Coding	4.86	DISEASES inferred ¹⁴
6	PTGER4	Prostaglandin E Receptor 4	Protein Coding	4.85	DISEASES inferred ¹⁴

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Variations for Inverted Follicular Keratosis

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Expression for Inverted Follicular Keratosis

Search GEO for disease gene expression data for Inverted Follicular Keratosis.

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Pathways for Inverted Follicular Keratosis

Pathways related to Inverted Follicular Keratosis according to GeneCards Suite gene sharing:

(showing 2, show less)

#	Super pathways	Score	Top Affiliating Genes
1	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics ⁶⁰	10.66	GP6 GP5
2	Platelet Adhesion to exposed collagen ⁶⁶ Show member pathways GP1b-IX-V activation signalling ⁶⁶	10.05	GP6 GP5

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GO Terms for Inverted Follicular Keratosis

Biological processes related to Inverted Follicular Keratosis according to GeneCards Suite gene sharing:

(showing 2, show less)

#	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation	GO:0007596	9.13	GP6 GP5
2	hemostasis	GO:0007599	8.62	GP6 GP5

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Sources for Inverted Follicular Keratosis

¹ BitterDB

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²⁶ GEO DataSets

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³¹ ICD10

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³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

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³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

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⁴³ MeSH

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⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

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⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

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⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: INV005 MIFTS: 26	Inverted Follicular Keratosis Categories: Cancer diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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