MCID: IDN001
MIFTS: 25

Iodine Hypothyroidism

Categories: Endocrine diseases

Aliases & Classifications for Iodine Hypothyroidism

MalaCards integrated aliases for Iodine Hypothyroidism:

Name: Iodine Hypothyroidism 12 15 70
Iodine Deficiency Hypothyroidism 17

Classifications:



External Ids:

Disease Ontology 12 DOID:5083
ICD9CM 34 244.2
SNOMED-CT 67 190279008
UMLS 70 C0154159

Summaries for Iodine Hypothyroidism

MalaCards based summary : Iodine Hypothyroidism, also known as iodine deficiency hypothyroidism, is related to hypothyroidism and goiter. An important gene associated with Iodine Hypothyroidism is TPO (Thyroid Peroxidase), and among its related pathways/superpathways are Allograft rejection and Aldosterone synthesis and secretion. The drugs Iodine and Cadexomer iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, cortex and adrenal cortex.

Related Diseases for Iodine Hypothyroidism

Diseases related to Iodine Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 hypothyroidism 29.7 TSHR TPO TG ALB
2 goiter 29.6 TSHR TPO TG
3 congenital hypothyroidism 29.1 TSHR TPO TG ALB
4 acute thyroiditis 10.1 TPO TG
5 mechanical strabismus 10.1 TPO TG
6 nonencapsulated sclerosing carcinoma 10.1 TPO TG
7 aspirin allergy 10.1 TPO TG
8 postsurgical hypothyroidism 10.1 TPO TG
9 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.1 TPO TG
10 type 1 diabetes mellitus 20 10.0 TPO TG
11 transient congenital hypothyroidism 10.0 TSHR TPO
12 adrenal cortical hypofunction 10.0 TPO TG
13 hypotropia 10.0 TSHR TPO
14 pernicious anemia 10.0 TPO TG
15 euthyroid sick syndrome 10.0 TG ALB
16 adrenal cortex disease 10.0 TPO TG
17 athyreosis 10.0 TSHR TG
18 papillary thyroid microcarcinoma 10.0 TSHR TG
19 hypoadrenocorticism, familial 10.0 TPO TG
20 struma ovarii 10.0 TSHR TG
21 benign struma ovarii 9.9 TSHR TG
22 orbital disease 9.9 TSHR TG
23 chronic urticaria 9.9 TPO TG
24 autoimmune polyendocrine syndrome 9.9 TPO TG
25 thyroid hormone resistance, generalized, autosomal dominant 9.9 TSHR TG
26 parathyroid gland disease 9.9 TG ALB
27 hypothyroidism, congenital, nongoitrous, 1 9.9 TSHR TG
28 hypothyroidism, congenital, nongoitrous, 2 9.9 TSHR TG
29 pendred syndrome 9.9 TPO TG
30 methylmalonic aciduria, cbla type 9.9 TPO ENO1
31 thyroid cancer, nonmedullary, 2 9.9 TSHR TG
32 familial thyroid dyshormonogenesis 9.9 TPO TG
33 limbic encephalitis 9.8 TPO ENO1
34 turner syndrome 9.8 TPO TG
35 giardiasis 9.8 ENO1 ALB
36 autoimmune pancreatitis 9.8 ENO1 ALB
37 autoimmune hepatitis 9.8 TPO ALB
38 celiac disease 1 9.8 TPO TG ALB
39 thyroid crisis 9.8 TSHR TPO TG
40 toxic diffuse goiter 9.8 TSHR TPO TG
41 subacute lymphocytic thyroiditis 9.8 TSHR TPO TG
42 thyroiditis 9.8 TSHR TPO TG
43 endemic goiter 9.8 TSHR TPO TG
44 plummer's disease 9.8 TSHR TPO TG
45 suppurative thyroiditis 9.8 TSHR TPO TG
46 nontoxic goiter 9.8 TSHR TPO TG
47 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.7 TSHR TPO TG
48 myxedema 9.7 TSHR TPO TG
49 subacute thyroiditis 9.7 TSHR TPO TG
50 type 1 diabetes mellitus 9.7 TPO TG ALB

Comorbidity relations with Iodine Hypothyroidism via Phenotypic Disease Network (PDN):


Hypertension, Essential Hypothyroidism

Graphical network of the top 20 diseases related to Iodine Hypothyroidism:



Diseases related to Iodine Hypothyroidism

Symptoms & Phenotypes for Iodine Hypothyroidism

Drugs & Therapeutics for Iodine Hypothyroidism

Drugs for Iodine Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational 7553-56-2 807
2
Cadexomer iodine Experimental 94820-09-4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Iodine Status in Pregnant Women in Israel Unknown status NCT03120221

Search NIH Clinical Center for Iodine Hypothyroidism

Genetic Tests for Iodine Hypothyroidism

Anatomical Context for Iodine Hypothyroidism

MalaCards organs/tissues related to Iodine Hypothyroidism:

40
Thyroid, Cortex, Adrenal Cortex

Publications for Iodine Hypothyroidism

Articles related to Iodine Hypothyroidism:

(show all 15)
# Title Authors PMID Year
1
A Systematic Review of Case-Identification Algorithms Based on Italian Healthcare Administrative Databases for Two Relevant Diseases of the Endocrine System: Diabetes Mellitus and Thyroid Disorders. 61
31650804 2019
2
Women's morbid conditions are associated with decreased odds of live birth in the first IVF/ICSI treatment: a retrospective single-center study. 61
30656502 2019
3
Utility of rituximab treatment for exophthalmos, myxedema, and osteoarthropathy syndrome resistant to corticosteroids due to Graves' disease: a case report. 61
29448964 2018
4
Veganism as a cause of iodine deficient hypothyroidism. 61
29303778 2018
5
Got Rice? An Unusual Case of Iodine-Deficiency Hypothyroidism. 61
27400805 2016
6
[Short-term results of treatment with 131I in patients with multinodular goiter: effect of the associated degree of hyperthyroidism and other variables]. 61
21481495 2011
7
Assessment of iodine and non-iodine deficiency hypothyroidism in women of reproductive ages in the sub-Himalayan plains of West Bengal. 61
20509329 2009
8
[Iodine deficiency hypothyroidism]. 61
16776169 2006
9
Prevalence of thyroid disorders in pregnant women with mild iodine deficiency. 61
14710590 2003
10
The prevalence of thyroid dysfunction in a population with borderline iodine deficiency. 61
10469017 1999
11
Radioiodine treatment in recurrences of subacute thyroiditis. 61
1981947 1990
12
Evolution of hypothyroidism in familial goitre due to deiodinase deficiency: report of a family and review of the literature. 61
3774680 1986
13
Iodine deficiency, hypothyroidism, and endemic goitre in southern Tanzania. A survey showing the positive effects of iodised oil injections by TSH determination in dried blood spots. 61
2995534 1985
14
[Thyrotoxicosis, then hypothyroidism caused by iodine overload (amiodarone) associated with neuropathy. Failure of plasma exchange]. 61
6305250 1983
15
Development of goiters in cretins without iodine deficiency: hypothyroidism due to apparent inability of the thyroid gland to synthesize hormone. 61
13155072 1954

Variations for Iodine Hypothyroidism

Expression for Iodine Hypothyroidism

Search GEO for disease gene expression data for Iodine Hypothyroidism.

Pathways for Iodine Hypothyroidism

Pathways related to Iodine Hypothyroidism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.07 TSHR TPO TG
2
Show member pathways
12.03 TSHR TPO TG ALB
3 9.58 TSHR TPO TG

GO Terms for Iodine Hypothyroidism

Cellular components related to Iodine Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 TPO TG ENO1 ALB
2 cell surface GO:0009986 8.8 TSHR TPO ENO1

Biological processes related to Iodine Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.16 TPO ALB
2 thyroid hormone generation GO:0006590 8.96 TPO TG
3 hormone biosynthetic process GO:0042446 8.62 TPO TG

Sources for Iodine Hypothyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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