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IRAK4D
MCID: IRK001
MIFTS: 49

Irak4 Deficiency (IRAK4D)

Categories: Blood diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Irak4 Deficiency

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MalaCards integrated aliases for Irak4 Deficiency:

Name: Irak4 Deficiency 57 53 25 59 75 29 13 6 40 73
Interleukin-1 Receptor-Associated Kinase 4 Deficiency 25 73
Irak-4 Deficiency 53 25
Irak4d 57 75
Immunodeficiency Due to Interleukin-1 Receptor-Associated Kinase-4 Deficiency 59
Interleukin Receptor-Associated Kinase Deficiency 53
Interleukin 1 Receptor-Associated Kinase 4 13

Characteristics:

Orphanet epidemiological data:

59
immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency
Inheritance: Autosomal recessive; Prevalence: <1/1000000 (Worldwide); Age of onset: Childhood; Age of death: any age;

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Blood diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare immunological diseases


External Ids:

OMIM 57 607676
Orphanet 59 ORPHA70592
ICD10 via Orphanet 34 D84.8
UMLS via Orphanet 74 C1843256
MedGen 42 C1843256
SNOMED-CT via HPO 69 165517008 234532001
Sources

Summaries for Irak4 Deficiency

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NIH Rare Diseases : 53 IRAK-4 deficiency is a condition that affects the immune system (primary immunodeficiency). It causes recurring severe infections by a type of bacteria called pyogenic bacteria. Individuals with IRAK-4 deficiency seem to be particularly susceptible to infections caused by bacteria called Streptococcus pneumoniae. The deficiency is caused by mutations in the IRAK4 gene and is inherited in an autosomal recessive pattern. Treatment may include intravenous immunoglobulin therapy (IVIG), taking antibiotics before an infection develops, and vaccines. Althought the infections can be life-threatening, they tend to occur less often as a person gets older.

MalaCards based summary : Irak4 Deficiency, also known as interleukin-1 receptor-associated kinase 4 deficiency, is related to leukocyte adhesion deficiency, type iii and waldenstroem's macroglobulinemia. An important gene associated with Irak4 Deficiency is IRAK4 (Interleukin 1 Receptor Associated Kinase 4), and among its related pathways/superpathways are Innate Immune System and HIV Life Cycle. Affiliated tissues include t cells, neutrophil and liver, and related phenotypes are immunodeficiency and neutropenia

Genetics Home Reference : 25 IRAK-4 deficiency is an inherited disorder of the immune system (primary immunodeficiency). This immunodeficiency leads to recurrent infections by a subset of bacteria known as pyogenic bacteria but not by other infectious agents. (Infection with pyogenic bacteria causes the production of pus.) The most common infections in IRAK-4 deficiency are caused by the Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa bacteria. Most people with this condition have their first bacterial infection before age 2, and the infections can be life-threatening in infancy and childhood. Infections become less frequent with age.

OMIM : 57 IRAK4 deficiency is an autosomal recessive primary immunodeficiency that impairs Toll (see TLR4; 603030)/IL1R (see IL1R1; 147810) immunity, except for the TLR3 (603029)- and TLR4-interferon-alpha (IFNA; 147660)/beta (IFNB; 147640) pathways (Ku et al., 2007). (607676)

UniProtKB/Swiss-Prot : 75 IRAK4 deficiency: Causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.

Wikipedia : 76 IRAK-4 (interleukin-1 receptor-associated kinase 4), in the IRAK family, is a protein kinase involved in... more...

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Related Diseases for Irak4 Deficiency

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Diseases related to Irak4 Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 leukocyte adhesion deficiency, type iii 11.2
2 waldenstroem's macroglobulinemia 10.2 BTK MYD88
3 plasma protein metabolism disease 10.1 BTK MYD88
4 pleuropneumonia 10.1 IRAK4 MYD88
5 invasive pneumococcal disease, recurrent isolated, 1 10.1 IRAK4 TIRAP
6 mycobacterium chelonae 10.1 CD14 TLR2
7 mycobacterium kansasii 10.1 CD14 TLR2
8 urethritis 10.1 TLR1 TLR6
9 pericarditis 10.1
10 pleural empyema 10.1
11 mesenteric lymphadenitis 10.1 MYD88 TLR2
12 mycobacterium abscessus 10.0 TLR1 TLR2
13 neutrophil migration 10.0
14 arthritis 10.0
15 juvenile rheumatoid arthritis 10.0
16 hyper ige syndrome 10.0
17 prosthetic joint infection 10.0 TLR2 TLR4
18 trench fever 10.0 TLR2 TLR4
19 fungal keratitis 10.0 TLR2 TLR4
20 acute cervicitis 10.0 TLR2 TLR4
21 neurosyphilis 10.0 TLR1 TLR2 TLR6
22 anterior uveitis 10.0 TLR2 TLR4
23 ariboflavinosis 10.0 TLR4 TLR6
24 lyme disease 10.0 TLR1 TLR2 TLR6
25 ocular toxoplasmosis 9.9 TLR1 TLR5
26 spondylarthropathy 9.9 TLR2 TLR4
27 myositis fibrosa 9.9 MYD88 TLR2 TLR4
28 alveolar echinococcosis 9.9 CD36 TLR2 TLR4
29 paracoccidioidomycosis 9.9 MYD88 TLR2 TLR4
30 toxoplasmosis 9.9 MYD88 TLR2 TLR4
31 niemann-pick disease, type c2 9.9 LY96 TLR4
32 neisseria meningitidis infection 9.9 TLR2 TLR4
33 bacteriuria 9.9 TIRAP TLR1 TLR4
34 legionnaires' disease 9.8 TLR4 TLR5 TLR6
35 mycobacterium tuberculosis 1 9.8 MYD88 TLR1 TLR2 TLR4
36 septic arthritis 9.8 TLR2 TLR4
37 penicilliosis 9.7 TLR1 TLR2 TLR4 TLR6
38 invasive aspergillosis 9.7 TLR1 TLR2 TLR4 TLR6
39 filariasis 9.7 TLR1 TLR2 TLR4 TLR6
40 suppurative otitis media 9.7 TLR2 TLR4 TLR5
41 ileitis 9.7 TLR2 TLR4 TLR5
42 q fever 9.7 TLR1 TLR10 TLR2 TLR4
43 pneumonia 9.7 TLR2 TLR4 TLR5
44 legionellosis 9.6 MYD88 TLR2 TLR4 TLR5
45 malaria 9.6 CD36 MYD88 TIRAP TLR2 TLR4
46 pelvic inflammatory disease 9.5 TIRAP TLR1 TLR2 TLR4 TLR6
47 bacterial infectious disease 9.4 IRAK4 MYD88 TLR1 TLR2 TLR4 TLR5
48 melioidosis 9.3 LY96 TLR1 TLR10 TLR2 TLR4 TLR5
49 myd88 deficiency 8.6 BTK CD14 CD36 IRAK4 LY96 MYD88

Graphical network of the top 20 diseases related to Irak4 Deficiency:



Diseases related to Irak4 Deficiency
Sources

Symptoms & Phenotypes for Irak4 Deficiency

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Clinical features from OMIM:

607676

Human phenotypes related to Irak4 Deficiency:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 immunodeficiency 59 32 hallmark (90%) Very frequent (99-80%) HP:0002721
2 neutropenia 59 32 hallmark (90%) Very frequent (99-80%) HP:0001875
3 recurrent streptococcus pneumoniae infections 59 32 hallmark (90%) Very frequent (99-80%) HP:0005366
4 recurrent staphylococcal infections 59 32 hallmark (90%) Very frequent (99-80%) HP:0007499
5 recurrent bacterial infections 59 Very frequent (99-80%)

MGI Mouse Phenotypes related to Irak4 Deficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.73 CD14 CD36 MYD88 TLR2 TLR4 TLR5
2 hematopoietic system MP:0005397 9.73 BTK CD14 CD36 IRAK4 LY96 MYD88
3 digestive/alimentary MP:0005381 9.63 BTK CD36 MYD88 TLR2 TLR4 TLR5
4 immune system MP:0005387 9.4 BTK CD14 CD36 IRAK4 LY96 MYD88
Sources

Drugs & Therapeutics for Irak4 Deficiency

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Search Clinical Trials , NIH Clinical Center for Irak4 Deficiency

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Genetic Tests for Irak4 Deficiency

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Genetic tests related to Irak4 Deficiency:

# Genetic test Affiliating Genes
1 Irak4 Deficiency 29 IRAK4
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Anatomical Context for Irak4 Deficiency

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MalaCards organs/tissues related to Irak4 Deficiency:

41
T Cells, Neutrophil, Liver, Testes
Sources

Publications for Irak4 Deficiency

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Articles related to Irak4 Deficiency:

# Title Authors Year
1
Corrigendum: IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature. ( 29531937 )
2018
2
IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature. ( 28503543 )
2017
3
Invasive Bacterial Infection in Patients with Interleukin-1 Receptor-associated Kinase 4 Deficiency: Case Report. ( 26825884 )
2016
4
IRAK4 deficiency promotes cardiac remodeling induced by pressure overload. ( 26884959 )
2015
5
Management of a transcranial abscess secondary to interleukin-1 receptor associated kinase 4 deficiency. ( 25569407 )
2015
6
Even in pneumococcal sepsis CD62L shedding on granulocytes proves to be a reliable functional test for the diagnosis of interleukin-1 receptor-associated kinase-4 deficiency. ( 23538514 )
2013
7
Profound reduction of invariant natural killer T cells in the peripheral blood of a patient with interleukin-1 receptor-associated kinase 4 deficiency. ( 20441778 )
2010
8
Staphylococcal pericarditis, and liver and paratracheal abscesses as presentations in two new cases of interleukin-1 receptor associated kinase 4 deficiency. ( 18174872 )
2008
9
Recurrent systemic pneumococcal disease and IRAK4 deficiency. ( 17984826 )
2007
Sources

Variations for Irak4 Deficiency

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UniProtKB/Swiss-Prot genetic disease variations for Irak4 Deficiency:

75
# Symbol AA change Variation ID SNP ID
1 IRAK4 p.Arg12Cys VAR_072888 rs377584435
2 IRAK4 p.Gly298Asp VAR_072892 rs568782766

ClinVar genetic disease variations for Irak4 Deficiency:

6 (show top 50) (show all 142)
# Gene Variation Type Significance SNP ID Assembly Location
1 IRAK4 IRAK4, 1-BP DEL, 821T deletion Pathogenic
2 IRAK4 NM_016123.3(IRAK4): c.877C> T (p.Gln293Ter) single nucleotide variant Pathogenic rs121908002 GRCh37 Chromosome 12, 44172041: 44172041
3 IRAK4 NM_016123.3(IRAK4): c.877C> T (p.Gln293Ter) single nucleotide variant Pathogenic rs121908002 GRCh38 Chromosome 12, 43778238: 43778238
4 IRAK4 IRAK4, 2-BP DEL, 620AC deletion Pathogenic
5 IRAK4 NM_016123.3(IRAK4): c.34C> T (p.Arg12Cys) single nucleotide variant Likely pathogenic rs377584435 GRCh37 Chromosome 12, 44161948: 44161948
6 IRAK4 NM_016123.3(IRAK4): c.34C> T (p.Arg12Cys) single nucleotide variant Likely pathogenic rs377584435 GRCh38 Chromosome 12, 43768145: 43768145
7 IRAK4 IRAK4, IVS7DS, G-T, +5 single nucleotide variant Pathogenic
8 IRAK4 NM_016123.3(IRAK4): c.-54G> A single nucleotide variant Uncertain significance rs886049383 GRCh38 Chromosome 12, 43758972: 43758972
9 IRAK4 NM_016123.3(IRAK4): c.-54G> A single nucleotide variant Uncertain significance rs886049383 GRCh37 Chromosome 12, 44152775: 44152775
10 IRAK4 NM_016123.3(IRAK4): c.713C> T (p.Ala238Val) single nucleotide variant Uncertain significance rs886049386 GRCh38 Chromosome 12, 43774026: 43774026
11 IRAK4 NM_016123.3(IRAK4): c.713C> T (p.Ala238Val) single nucleotide variant Uncertain significance rs886049386 GRCh37 Chromosome 12, 44167829: 44167829
12 IRAK4 NM_016123.3(IRAK4): c.1282G> A (p.Ala428Thr) single nucleotide variant Benign rs4251545 GRCh38 Chromosome 12, 43786492: 43786492
13 IRAK4 NM_016123.3(IRAK4): c.1282G> A (p.Ala428Thr) single nucleotide variant Benign rs4251545 GRCh37 Chromosome 12, 44180295: 44180295
14 IRAK4 NM_016123.3(IRAK4): c.*989T> G single nucleotide variant Uncertain significance rs4251584 GRCh37 Chromosome 12, 44181507: 44181507
15 IRAK4 NM_016123.3(IRAK4): c.*989T> G single nucleotide variant Uncertain significance rs4251584 GRCh38 Chromosome 12, 43787704: 43787704
16 IRAK4 NM_016123.3(IRAK4): c.*1306C> T single nucleotide variant Uncertain significance rs770097373 GRCh37 Chromosome 12, 44181824: 44181824
17 IRAK4 NM_016123.3(IRAK4): c.*1306C> T single nucleotide variant Uncertain significance rs770097373 GRCh38 Chromosome 12, 43788021: 43788021
18 IRAK4 NM_016123.3(IRAK4): c.*1435T> G single nucleotide variant Uncertain significance rs886049393 GRCh37 Chromosome 12, 44181953: 44181953
19 IRAK4 NM_016123.3(IRAK4): c.*1435T> G single nucleotide variant Uncertain significance rs886049393 GRCh38 Chromosome 12, 43788150: 43788150
20 IRAK4 NM_016123.3(IRAK4): c.*1794T> C single nucleotide variant Benign rs4251555 GRCh37 Chromosome 12, 44182312: 44182312
21 IRAK4 NM_016123.3(IRAK4): c.*1794T> C single nucleotide variant Benign rs4251555 GRCh38 Chromosome 12, 43788509: 43788509
22 IRAK4 NM_016123.3(IRAK4): c.*1974G> A single nucleotide variant Uncertain significance rs12321678 GRCh37 Chromosome 12, 44182492: 44182492
23 IRAK4 NM_016123.3(IRAK4): c.*1974G> A single nucleotide variant Uncertain significance rs12321678 GRCh38 Chromosome 12, 43788689: 43788689
24 IRAK4 NM_016123.3(IRAK4): c.*2071C> T single nucleotide variant Uncertain significance rs776314485 GRCh37 Chromosome 12, 44182589: 44182589
25 IRAK4 NM_016123.3(IRAK4): c.*2071C> T single nucleotide variant Uncertain significance rs776314485 GRCh38 Chromosome 12, 43788786: 43788786
26 IRAK4 NM_016123.3(IRAK4): c.*2188A> G single nucleotide variant Benign rs1141168 GRCh38 Chromosome 12, 43788903: 43788903
27 IRAK4 NM_016123.3(IRAK4): c.*2188A> G single nucleotide variant Benign rs1141168 GRCh37 Chromosome 12, 44182706: 44182706
28 IRAK4 NM_016123.3(IRAK4): c.*2666G> T single nucleotide variant Uncertain significance rs375914722 GRCh38 Chromosome 12, 43789381: 43789381
29 IRAK4 NM_016123.3(IRAK4): c.*2666G> T single nucleotide variant Uncertain significance rs375914722 GRCh37 Chromosome 12, 44183184: 44183184
30 IRAK4 NM_016123.3(IRAK4): c.613G> A (p.Val205Ile) single nucleotide variant Uncertain significance rs370225662 GRCh38 Chromosome 12, 43773034: 43773034
31 IRAK4 NM_016123.3(IRAK4): c.613G> A (p.Val205Ile) single nucleotide variant Uncertain significance rs370225662 GRCh37 Chromosome 12, 44166837: 44166837
32 IRAK4 NM_016123.3(IRAK4): c.*146T> C single nucleotide variant Likely benign rs4251546 GRCh38 Chromosome 12, 43786861: 43786861
33 IRAK4 NM_016123.3(IRAK4): c.*146T> C single nucleotide variant Likely benign rs4251546 GRCh37 Chromosome 12, 44180664: 44180664
34 IRAK4 NM_016123.3(IRAK4): c.*520T> A single nucleotide variant Uncertain significance rs4251550 GRCh38 Chromosome 12, 43787235: 43787235
35 IRAK4 NM_016123.3(IRAK4): c.*520T> A single nucleotide variant Uncertain significance rs4251550 GRCh37 Chromosome 12, 44181038: 44181038
36 IRAK4 NM_016123.3(IRAK4): c.*608A> G single nucleotide variant Likely benign rs4251551 GRCh37 Chromosome 12, 44181126: 44181126
37 IRAK4 NM_016123.3(IRAK4): c.*608A> G single nucleotide variant Likely benign rs4251551 GRCh38 Chromosome 12, 43787323: 43787323
38 IRAK4 NM_016123.3(IRAK4): c.*1115G> T single nucleotide variant Uncertain significance rs886049391 GRCh37 Chromosome 12, 44181633: 44181633
39 IRAK4 NM_016123.3(IRAK4): c.*1115G> T single nucleotide variant Uncertain significance rs886049391 GRCh38 Chromosome 12, 43787830: 43787830
40 IRAK4 NM_016123.3(IRAK4): c.*1161G> A single nucleotide variant Uncertain significance rs545334973 GRCh37 Chromosome 12, 44181679: 44181679
41 IRAK4 NM_016123.3(IRAK4): c.*1161G> A single nucleotide variant Uncertain significance rs545334973 GRCh38 Chromosome 12, 43787876: 43787876
42 IRAK4 NM_016123.3(IRAK4): c.*1325G> A single nucleotide variant Uncertain significance rs139778399 GRCh37 Chromosome 12, 44181843: 44181843
43 IRAK4 NM_016123.3(IRAK4): c.*1325G> A single nucleotide variant Uncertain significance rs139778399 GRCh38 Chromosome 12, 43788040: 43788040
44 IRAK4 NM_016123.3(IRAK4): c.*1999dupT duplication Uncertain significance rs886049394 GRCh37 Chromosome 12, 44182517: 44182517
45 IRAK4 NM_016123.3(IRAK4): c.*1999dupT duplication Uncertain significance rs886049394 GRCh38 Chromosome 12, 43788714: 43788714
46 IRAK4 NM_016123.3(IRAK4): c.*2083C> G single nucleotide variant Uncertain significance rs111813306 GRCh38 Chromosome 12, 43788798: 43788798
47 IRAK4 NM_016123.3(IRAK4): c.*2083C> G single nucleotide variant Uncertain significance rs111813306 GRCh37 Chromosome 12, 44182601: 44182601
48 IRAK4 NM_016123.3(IRAK4): c.*2345A> G single nucleotide variant Uncertain significance rs368152755 GRCh38 Chromosome 12, 43789060: 43789060
49 IRAK4 NM_016123.3(IRAK4): c.*2345A> G single nucleotide variant Uncertain significance rs368152755 GRCh37 Chromosome 12, 44182863: 44182863
50 IRAK4 NM_016123.3(IRAK4): c.*2704C> T single nucleotide variant Likely benign rs4251562 GRCh38 Chromosome 12, 43789419: 43789419
Sources

Expression for Irak4 Deficiency

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Search GEO for disease gene expression data for Irak4 Deficiency.
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Pathways for Irak4 Deficiency

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Pathways related to Irak4 Deficiency according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.02 BTK CD14 CD36 IRAK4 LY96 MYD88
2
HIV Life Cycle 66
Show member pathways
 13.68 BTK CD14 CD36 IRAK4 LY96 MYD88
3
Activated TLR4 signalling 66
Show member pathways
 13.53 BTK CD14 CD36 IRAK4 LY96 MYD88
4
Class I MHC mediated antigen processing and presentation 66
Show member pathways
 13.49 BTK CD14 CD36 LY96 MYD88 TIRAP
5
Akt Signaling 64
Show member pathways
 13.44 BTK IRAK4 MYD88 TIRAP TLR1 TLR10
6
IL-2 Pathway 64
Show member pathways
 13.26 BTK CD14 IRAK4 MYD88 TLR1 TLR10
7
Human cytomegalovirus infection 37
Show member pathways
 12.98 IRAK4 MYD88 TIRAP TLR2 TLR4
8
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.95 BTK CD14 IRAK4 LY96 MYD88 TIRAP
9
NF-KappaB Family Pathway 64
Show member pathways
 12.78 IRAK4 MYD88 TLR1 TLR10 TLR2 TLR4
10
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.74 CD14 LY96 MYD88 TIRAP TLR4
11
Influenza A 37
Show member pathways
 12.69 IRAK4 MYD88 TLR2 TLR4
12
NF-kappaB Signaling 4
12.63 BTK IRAK4 MYD88 TLR1 TLR2 TLR6
13
TRAF Pathway 64
Show member pathways
 12.57 BTK CD14 IRAK4 LY96 MYD88 TIRAP
14
Development FGFR signaling pathway 22
Show member pathways
 12.52 CD14 IRAK4 LY96 MYD88 TIRAP TLR4
15
Development Slit-Robo signaling 22
Show member pathways
 12.49 CD14 LY96 TLR4 TLR5
16
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.46 BTK CD14 CD36 IRAK4 LY96 MYD88
17
Toll Comparative Pathway 64
Show member pathways
 12.4 CD14 IRAK4 LY96 MYD88 TIRAP TLR4
18
Toxoplasmosis 37
Show member pathways
 12.33 IRAK4 LY96 MYD88 TLR2 TLR4
19
VEGF Pathway (Qiagen) 22
Show member pathways
 12.31 BTK CD14 IRAK4 LY96 MYD88 TIRAP
20
IL-1 Family Signaling Pathways 65
Show member pathways
 12.3 IRAK4 MYD88 TIRAP TLR2 TLR5
21
Colorectal Cancer Metastasis 64
12.3 TLR1 TLR10 TLR2 TLR4 TLR5 TLR6
22
Dimerization of procaspase-8 66
Show member pathways
 12.29 BTK CD14 LY96 TLR4
23
Epstein-Barr virus infection 37
12.29 BTK IRAK4 MYD88 TLR2
24
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.29 BTK IRAK4 MYD88 TLR1 TLR10 TLR2
25
Tuberculosis 37
12.26 CD14 IRAK4 MYD88 TIRAP TLR1 TLR2
26
Phagosome 37
12.23 CD14 CD36 TLR2 TLR4 TLR6
27
Th1 Differentiation Pathway 65
Show member pathways
 12.17 TLR1 TLR10 TLR2 TLR4 TLR5 TLR6
28
MAPK Pathway 72
Show member pathways
 12.15 TLR1 TLR10 TLR2 TLR4 TLR5 TLR6
29
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 12.12 CD14 CD36 LY96 TLR1 TLR2 TLR4
30
Antigen processing-Cross presentation 66
Show member pathways
 12.1 BTK CD14 CD36 LY96 MYD88 TIRAP
31
NF-kappa B signaling pathway 37
11.98 BTK CD14 IRAK4 LY96 MYD88 TIRAP
32
Phagocytosis of Microbes 64
11.95 TLR1 TLR10 TLR2 TLR4 TLR5 TLR6
33
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.94 CD14 LY96 MYD88 TLR4
34
Salmonella infection (KEGG) 37
11.9 CD14 MYD88 TLR4 TLR5
35
Pertussis 37
11.88 CD14 IRAK4 LY96 MYD88 TIRAP TLR4
36
Amoebiasis 37
11.85 CD14 TLR2 TLR4
37
NF-kB (NFkB) Pathway 67
11.84 BTK CD14 IRAK4 LY96 MYD88 TLR4
38
Legionellosis 37
11.73 CD14 MYD88 TLR2 TLR4 TLR5
39
AGE/RAGE pathway 1
11.68 IRAK4 MYD88 TIRAP
40
Transcription_NF-kB signaling pathway 22
11.68 CD14 LY96 MYD88 TLR4
41
Malaria 37
11.63 CD36 MYD88 TLR2 TLR4
42
Bacterial infections in CF airways 22
Show member pathways
 11.54 CD14 IRAK4 LY96 MYD88 TIRAP TLR1
43
A-beta Pathways: Uptake and Degradation 65
11.43 CD14 CD36 LY96 TLR4
44
IL1 and megakaryocytes in obesity 1
11.25 MYD88 TLR1 TLR2
45
IKK complex recruitment mediated by RIP1 66
11.23 CD14 LY96 TLR4
46
NTHi-Induced Signaling 64
11.02 MYD88 TLR2
47
MIF Action Through Endocytic Pathway 64
10.91 CD14 LY96 TLR4
Sources

GO Terms for Irak4 Deficiency

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Cellular components related to Irak4 Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.97 BTK CD14 CD36 IRAK4 LY96 MYD88
2 integral component of plasma membrane GO:0005887 9.91 CD36 TLR1 TLR10 TLR2 TLR4 TLR6
3 endosome membrane GO:0010008 9.65 CD14 IRAK4 LY96 MYD88 TLR4
4 phagocytic vesicle membrane GO:0030670 9.58 TLR1 TLR2 TLR6
5 intrinsic component of plasma membrane GO:0031226 9.54 LY96 TLR2 TLR4
6 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.32 TLR1 TLR2
7 lipopolysaccharide receptor complex GO:0046696 9.13 CD14 LY96 TLR4
8 membrane raft GO:0045121 9.1 BTK CD14 CD36 TLR1 TLR2 TLR6

Biological processes related to Irak4 Deficiency according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.99 CD36 MYD88 TIRAP TLR2
2 apoptotic signaling pathway GO:0097190 9.96 BTK CD14 LY96 TLR4
3 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.95 BTK CD14 LY96 TLR4
4 positive regulation of tumor necrosis factor production GO:0032760 9.95 CD14 CD36 LY96 MYD88 TIRAP TLR2
5 positive regulation of interleukin-6 production GO:0032755 9.94 CD36 MYD88 TLR2 TLR4
6 innate immune response GO:0045087 9.93 BTK CD14 IRAK4 LY96 MYD88 TIRAP
7 positive regulation of nitric oxide biosynthetic process GO:0045429 9.92 CD36 TLR4 TLR5 TLR6
8 lipopolysaccharide-mediated signaling pathway GO:0031663 9.92 CD14 LY96 MYD88 TLR2 TLR4
9 response to bacterium GO:0009617 9.91 CD14 CD36 TLR4
10 positive regulation of interleukin-8 production GO:0032757 9.91 MYD88 TIRAP TLR2 TLR4 TLR5
11 positive regulation of JNK cascade GO:0046330 9.9 MYD88 TIRAP TLR4
12 cellular response to mechanical stimulus GO:0071260 9.9 MYD88 TLR4 TLR5
13 positive regulation of inflammatory response GO:0050729 9.9 TLR10 TLR2 TLR4
14 positive regulation of interleukin-12 production GO:0032735 9.9 CD36 TIRAP TLR2 TLR4
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 CD14 TLR2 TLR4
16 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.89 CD14 LY96 TLR4 TLR6
17 cellular response to amyloid-beta GO:1904646 9.88 CD36 TLR4 TLR6
18 necroptotic process GO:0070266 9.85 CD14 LY96 TLR4
19 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.85 MYD88 TLR4 TLR6
20 toll-like receptor 4 signaling pathway GO:0034142 9.85 CD14 LY96 TLR4
21 cellular response to lipoteichoic acid GO:0071223 9.85 CD14 CD36 TIRAP TLR2 TLR4
22 negative regulation of growth of symbiont in host GO:0044130 9.84 CD36 MYD88 TIRAP
23 positive regulation of interleukin-8 secretion GO:2000484 9.84 CD14 TLR1 TLR2
24 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.84 CD36 MYD88 TLR4 TLR6
25 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.83 CD36 TLR4 TLR6
26 cell activation GO:0001775 9.82 TLR1 TLR2 TLR6
27 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.81 CD14 LY96 TLR4
28 interleukin-1 beta secretion GO:0050702 9.8 CD36 TLR4 TLR6
29 cellular response to diacyl bacterial lipopeptide GO:0071726 9.8 CD14 CD36 TLR2 TLR6
30 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.79 CD14 LY96 TLR4
31 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.79 TIRAP TLR1 TLR6
32 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.78 CD36 TLR4 TLR6
33 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.78 CD14 CD36 TLR2 TLR6
34 cellular response to bacterial lipopeptide GO:0071221 9.76 CD36 TIRAP TLR2
35 positive regulation of interferon-beta production GO:0032728 9.75 TLR2 TLR4
36 positive regulation of interleukin-10 production GO:0032733 9.75 TLR2 TLR4
37 positive regulation of chemokine production GO:0032722 9.75 TLR2 TLR4
38 microglial cell activation GO:0001774 9.75 TLR2 TLR6
39 cellular response to triacyl bacterial lipopeptide GO:0071727 9.75 CD14 TLR1 TLR2
40 response to fatty acid GO:0070542 9.74 CD36 TLR2
41 activation of NF-kappaB-inducing kinase activity GO:0007250 9.74 TIRAP TLR6
42 positive regulation of macrophage activation GO:0043032 9.74 TLR4 TLR6
43 toll-like receptor 9 signaling pathway GO:0034162 9.74 IRAK4 MYD88
44 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.74 TLR2 TLR4
45 3'-UTR-mediated mRNA stabilization GO:0070935 9.74 MYD88 TIRAP
46 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.74 CD14 TLR1 TLR2
47 I-kappaB phosphorylation GO:0007252 9.73 TLR2 TLR4
48 response to molecule of bacterial origin GO:0002237 9.73 CD14 TLR2
49 macrophage activation GO:0042116 9.73 TLR1 TLR4
50 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.73 TLR1 TLR4

Molecular functions related to Irak4 Deficiency according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.97 BTK MYD88 TIRAP TLR1 TLR10 TLR2
2 protein heterodimerization activity GO:0046982 9.88 TIRAP TLR1 TLR2 TLR4 TLR6
3 transmembrane signaling receptor activity GO:0004888 9.83 TLR1 TLR10 TLR4 TLR5 TLR6
4 signaling receptor activity GO:0038023 9.8 TLR1 TLR2 TLR4 TLR6
5 interleukin-1 receptor binding GO:0005149 9.58 IRAK4 MYD88 TLR5
6 lipopolysaccharide binding GO:0001530 9.56 CD14 LY96 TLR2 TLR4
7 Toll-like receptor binding GO:0035325 9.5 CD36 MYD88 TLR2
8 Toll-like receptor 4 binding GO:0035662 9.46 LY96 TIRAP
9 lipopolysaccharide receptor activity GO:0001875 9.33 LY96 TLR2 TLR4
10 Toll-like receptor 2 binding GO:0035663 9.13 TIRAP TLR1 TLR6
11 lipopeptide binding GO:0071723 8.92 CD14 TLR1 TLR2 TLR6
12 protein binding GO:0005515 10.32 BTK CD14 CD36 IRAK4 LY96 MYD88
Sources

Sources for Irak4 Deficiency

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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